CN1108527A - Synergistic compositions for hair restoration - Google Patents
Synergistic compositions for hair restoration Download PDFInfo
- Publication number
- CN1108527A CN1108527A CN94104273.1A CN94104273A CN1108527A CN 1108527 A CN1108527 A CN 1108527A CN 94104273 A CN94104273 A CN 94104273A CN 1108527 A CN1108527 A CN 1108527A
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- CN
- China
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- preparation
- compositions
- sulfhydryl
- releasing agent
- sulfonyl methane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a synergistic compound containing methyl sulfonyl methane and one kind of physiologically-acceptable organic hydrosulfuryl internal releasing agent and its preparation and method for curing baldness and stimulating the growth of hair.
Description
The present invention relates to a kind of cooperative compositions that is used for hair restoration.
Excessively the coming off and get a bit thin on top in early days of hair remains the problem that people pay close attention to, and this is not only because the requirement in the treatment, also because of HA sense and social influence that it brought.Solve this problem though produced various products, do not have a kind of product to develop at the initial pathological process of relevant alopecia.Therefore, they have only limited effect, or short effect of persistent period, and almost do not have what curative effect in case alopecia takes place again.So the object of the invention is avoided exactly or is reduced this or more defects.
The invention provides a kind of scalp condition cooperative compositions that is used to improve, it comprises releasing agent in methyl sulfonyl methane (MSM) and a kind of physiologically-acceptable organic sulfhydryl body.
Find unexpectedly, in MSM, add and to contain sulfhydryl reagent to have improved this medicament greatly in synergistic mode anti-loss and stimulate the curative effect of hair growth promoting.That is to say that every kind of independent effect sum of component is less than the effect that they combine and produce jointly.But also find that this compositions has the advantage that is attached to skin.Can prolong the time of contact in it and affected part thus and improve therapeutic and discharge.The vivo and vitro experiment shows that compositions of the present invention has following effect:
1. removing oxygen-derived free radicals, these free radicals relate to the cytotoxic agent of disorganization and damage, the process that weakens healing and repair.
2. protection cytosis is meant the physicochemical property that can keep biological tissue, thereby strengthens the resistance of these tissues to the toxicity stimulus object.
3. biosynthesis and element sulphur is provided, but healing acceleration and reparation.
When not limiting the scope of the invention, we believe that one or more these effect has more or less embodied the beneficial effect that the present composition produced to a certain extent.
The preferred sulfhydryl releasing agent of the present invention comprises cysteine, half Guang ammonia, cystine, dimethyl sulfoxide, the esterified methionine of carboxyl, esterified group preferably have the low alkyl group of 1 to 6 carbon atom, as methyl, the ternary sulfonium derivant of the methyl substituted methionine of S-, as bromination, iodate or chlorination methionine-S-methyl sulfonium.Some has one or more optically actives center at least in the above-claimed cpd, especially in aminoacid by on that carbon atom of amino and carboxyl substituted.For getting rid of doubt to them, we find that through observing the present invention can expand to single isomers such as D and L-isomer and enantiomer, and have simultaneous diastereomer in two or more optically actives center and mixture of isomers to comprise racemic DL-mixture.
According to the present invention, the cooperative compositions that releasing agent in MSM and the organic sulfhydryl body is formed imposes on scalp, can improve scalp condition, promptly stops coming off and stimulating hair once weakened or suppress but do not have to grow the hair follicle of death from function of hair.Better, can further improve the effectiveness of compositions in the scalp as the vasodilation of adding resemble the menthol.
On the other hand, the invention provides a kind ofly, improve scalp condition by suppressing alopecia and bald head with the present composition and the complete blended pharmaceutical composition of physiologically acceptable carrier.This carrier the best is an Oleum Ricini, and surprisingly it can significantly reduce excessively coming off of hair, produces cooperative effect with the invention compositions even.
Also have on the one hand, the application proposes a kind of topical preparation, and it contains the present composition and the complete blended mixture of pharmaceutically acceptable carrier.These carriers are harmless to the scalp of being treated generally, and with the prescription in other compositions be compatible.The scalp that it must be emphasized that some individual patient than common people's sensitivity many, so these in particular cases need to change carrier mass commonly used.
Appropriate carriers is well-known in the art, and for example all has explanation at some in such as the British National Formulary and the British Pharmacopceia authority works.These carriers comprise ointment base, cream base and washing liquid, paste, jelly, spray, aerosol and bath oil.Ointment and cream can contain the colloidal clay that oil is absorbed, such as Huang work glue, and the acceptable supplementary element that certain purposes is arranged in preparation on the thickening agent of this class of alginate and other preparations, as wetting agent, antiseptic, buffer and antioxidant.
The every kind of component that is comprised in the preparation of the local usefulness of the present invention is at least 0.5%w/w, preferred 1～30%w/w, and the best is 1～10%w/w, as the dimethyl sulfoxide of 5%MSM and 2%, cysteine or Yucron.When adding menthol, proportioning is generally 1～30%, and the best is 1～5%w/w.
In addition, the present composition also can be with appropriate carriers such as distilled water but not the oral or parenteral of Oleum Ricini form.
During oral administration, compositions of the present invention and attached composition thereof can be made the potus form of water, syrup, capsule, sachet, bolus or tablet; Form of suspension in aqueous solution or oil solution or suspension or the syrup, this suspension can optionally contain suspending agent, or oil-in-water, water in oil emulsion form.Need or in case of necessity, also can comprise essence in the preparation, sweeting agent, antiseptic, thickening agent or emulsifying agent.Can contain compositions of the present invention and arbitrary accompaniment in the tablet arbitrarily and binding agent, lubricant, inert diluent or surface active ingredient or dispersant with powdery or Granular forms.
During parenteral, can with the present composition and arbitrary accompaniment is made sterile solution or in aqueous solution or oily carrier the suspension in the carrier, it also can contain antiseptic, antioxidant and some make solution or suspension and the isoosmotic material of receptor's blood.This preparation is convenient to make unit dose or many multiple doses are packaged in the container.
For oral or parenteral, the form concentration that active ingredient of the present invention is preferably made many multiple doses is from 0.5% to 15%w/v, and the best is 2 to 5%w/v solution, suspension or emulsion.When being unit dosage form, the preferable range that per unit dosage contains every kind of composition is 50～500mg.Can obey this dosage one or many every day, preferred 2～8 hours of blanking time, the best be per 6 hours clothes once.In the carrier of slow release or sustained release form, can take composition of the present invention better.Such various appropriate carrier has been well known in the art.
For topical therapeutic, impose on compositions on the skin 1～3 time every day, and it is coated whole scalp, massaged about 3～5 minutes.
Can further understand the better feature and advantage of the present invention by the following example, its purpose only is to illustrate the present invention.
The preparation of the topical preparation of embodiment 1 treatment scalp
A. methyl sulfonyl methane 5g
Dimethyl sulfoxide 2g
Cysteine hydrochloride 2g
Menthol crystal 1g
Oleum Ricini 100ml
B. methyl sulfonyl methane 5g
Dimethyl sulfoxide 2g
Yucron 2g
Menthol crystal 1g
Oleum Ricini 100ml
C. methyl sulfonyl methane 5g
Dimethyl sulfoxide 2g
Cysteine hydrochloride 2g
Yucron 2g
Menthol crystal 1g
Oleum Ricini 100ml
These preparations of preparation about 25 ℃.In glass container when large-tonnage product (if preparation also can use rustless steel container), 5gMSM is mixed with 2g cysteine hydrochloride and/or Yucron.Add Oleum Ricini then and stir a few minutes, parked 15 minutes, add the levigated menthol crystal of 1g.Mixture was left standstill 15 minutes again, add the 2g dimethyl sulfoxide of solution form then, whole mixture is stirred a few minutes, leave standstill half an hour before using.After preparation is finished, preparation can not long term exposure in air, can not directly tan by the sun under sunlight.Product should be deposited in the dark-coloured sealed glass jars away from outside the sunlight, preserves about 26 ℃ of optimum temperature.
Embodiment 2 local therapeutic approaches
Can be applied to scalp repeatedly every day with above-mentioned preparation.Can keep when use evening and spend the night, use warm water and fancy soap flush away second day morning.Most preferred therapy is every day twice, wherein once keeps and spends the night.Generally need the treatment some months, be preferably 8 months.All dispensers every day during beginning, after 6 months, can be kept to spends the night uses on every Wendesdays and time to finish until treatment.
The detailed evaluation of 3 pairs of said preparations of embodiment.
Following clinical trial is to carry out on the randomness double-blind method basis of expection, accomplishes randomization with the extraction seal envelopes.
A. detect MSM, dimethyl sulfoxide and contain the effect of the MSM solution of dimethyl sulfoxide to the excessive alopecia of male with redistilled water preparation.Generally be respectively these three kinds of solution parts to be imposed on scalp twice every day, each massaging scalp a few minutes.On scalp, keep after the dispenser in evening and spend the night, kept 3-6 hour during the daytime dispenser.
The patient is divided into one group of per 20 people at random, and the range of age is 25～39 years old in the whole test.Treat make known after 4 months the treatment number.Be observed result below:
No longer find alopecia
Therapy (n=20) %
n
0.5%MSM 1 5%
1%MSM 2 10%
2%MSM 3 15%
5%MSM 5 25%
10%MSM 5 25%
20%MSM 5 25%
30%MSM 5 25%
0.5%MSM 1 5%
1%DMSO 1 5%
2%DMSO 2 10%
5%DMSO 2 10%
10%DMSO 2 10%
20%DMSO 2 10%
30%DMSO 2 10%
0.5MSM+0.5DMSO 4 20%
1%MSM+1%DMSO 6 30%
2%MSM+2%DMSO 8 40%
5%MSM+5%DMSO 12 60%
10%MSM+10%DMSO 12 60%
20%MSM+20%DMSO 12 60%
30%MSM+30%DMSO 12 60%
MSM: methyl sulfonyl methane
DMSO: dimethyl sulfoxide
In this test, during with combing hair or massaging scalp on alopecia and the patient's clothes frequent visible hair be defined as hair and excessively come off.Successfully treatment is meant and again can't see this alopecia phenomenon.The result shows that MSM and dimethyl sulfoxide all can produce useful curative effect to excessive alopecia.And these two kinds of effects can obtain the concertedness raising after being used in combination these two kinds of materials.Anaphylaxis not taking place and to the side effect of skin or health, and can be accepted well by the patient in these therapies.This test shows that the MSM that lists in the example 1 and the dosage of dimethyl sulfoxide are optimum (optimal doses).
B. as above-mentioned test, adopt same scheme and the same problem of explanation to carry out another test, be used for checking the effect that is produced when using multiple sulfur-bearing regent.The range of age of whole test is 24～36 years old.Observed result is as follows:
Therapy (n=20) is no longer found alopecia, n %
5%MSM+2%DMSO 12 60%
2% cysteine hydrochloride 2 10%
5%MSM+2%DMSO+2% hydrochloric acid
Cysteine 16 80%
2% Yucron 2 10%
The 5%MSM+2%DMSO+2% chlorination
Methylmethionine sulfonium 16 80%
2% cysteine hydrochloride+2% methyl chloride
Methionine sulfonium 4 20%
5%MSM+2%DMSO+2% hydrochloric acid
Half amine propylhomoserin+2% methyl chloride methionine 20 100%
Sulfonium
Solution is prepared with twice distilled water.
MSM: methyl sulfonyl methane
DMSO: dimethyl sulfoxide
The result shows that adding multiple sulfur-bearing agent in MSM can improve the curative effect of treatment alopecia by cooperative mode.Do not have anaphylaxis, part or whole body are not had side effects yet.All methods are all accepted well by patient.
The dosage of cysteine and Yucron all is based on the use amount of dimethyl sulfoxide in the above-mentioned test in this test.
C. the 3rd test is the facilitation of check to natural on-off cycles of hair growth.This phenomenon of hair is appearred in original bareheaded position be defined as natural on-off cycles of hair growth.The patient is divided into one group of 20 people (the range of age of whole test is 28-43 year) randomly.Dispenser every day is 2 times then, treats 6 months, and the once reservation of using is every night spent the night.Therapy changes every day 2 times into then, 3 days weekly, uses 6 months again.Massage skin a few minutes when using gently at every turn.The dispenser on daytime was preserved 3 hours on scalp at least.The preparation of all preparations is all consistent with the method that describes in detail among the embodiment 1, treats after 1 year, makes known the treatment number.The result is as follows:
Therapy (n=20) is found natural on-off cycles of hair growth, n %
Oleum Ricini B.P. 0 0%
Oleum Ricini+1% menthol 2 10%
Oleum Ricini+1% menthol+2% hydrochloric acid half
Cystine 4 20%
Oleum Ricini+1% menthol+2% chlorination first
Base methionine sulfonium 4 20%
Oleum Ricini+1% menthol+5% methyl sulphur 10 50%
Acyl methane+2% dimethyl sulfoxide
Oleum Ricini+1% menthol+5% methyl sulphur
Acyl methane+2% dimethyl sulfoxide+2% salt 14 70%
The acid cysteine
Oleum Ricini+1% menthol+5% methyl sulphur
Acyl methane+2% dimethyl sulfoxide+2% chlorine 14 70%
Change the methylmethionine sulfonium
Oleum Ricini+1% menthol+5% methyl sulphur
Acyl methane+2% dimethyl sulfoxide+2% salt 18 90%
Acid cysteine+2% methyl chloride egg ammonia
The acid sulfonium
These results show that adding menthol in Oleum Ricini can strengthen the existing anti-loss beneficial effect of Oleum Ricini and can stimulate natural on-off cycles of hair growth largely.In addition, organic sulfhydryl releasing agent can be to stimulating the effect of natural on-off cycles of hair growth generation obvious synergistic in the adding body in the conjugate of methyl sulfonyl methane and dimethyl sulfoxide.This test has further confirmed every kind of effect that the active component preferred dose produces.
The therapy of all employings can both well be accepted by the patient, does not have anaphylaxis, also can not have side effects to part or whole body.
In this test, all patients are carried out a medical examination weekly, also carry out general blood and biochemical test (comprising the experiment of liver and renal function, the detection of blood glucose, serum amylase and vim and vigour) and urine sample inspection simultaneously.Carry out the horizontal check of twice electrocardiogram and cardiac enzymes system weekly.Under any circumstance in the safety reflection to used preparation, all do not find toxicity or biochemistry/blood dyscrasia phenomenon.
What deserves to be mentioned is, for synergistic combination thing of the present invention, though methyl sulfonyl methane and the best consumption of hydrogeneous methylthio group releasing agent identical (by weight) also can use other ratios.Common used proportion is 10: 1-1: 10, and preferable range is 5: 1-1: 5, most preferably (by weight) about 1: 1.Though to another aminoacid institute preferred proportion difference, as described preferable case, the ratio of methyl sulfonyl methane and cysteine or methionine is approximately 5: 2 or 5: 1 from an aminoacid.
Claims (17)
1, a kind of cooperative compositions, it contains releasing agent in methyl sulfonyl methane and a kind of physiologically-acceptable organic sulfhydryl body.
2, according to the compositions of claim 1, wherein said sulfhydryl releasing agent is selected from cysteine, cysteamine, cystine, dimethyl sulfoxide, the methionine derivant of esterified methionine of carboxyl and the methyl substituted ternary sulfonium of S-.
3, according to the compositions of claim 2, wherein said carboxyl is by the low alkyl group esterification of 1～6 carbon atom.
4, according to the compositions of claim 2, wherein the derivant of methionine comprises bromination, iodate or chlorination methionine-S-methyl sulfonium.
5, according to arbitrary compositions of claim 1 to 4, the weight ratio of wherein said methyl sulfonyl methane and sulfhydryl releasing agent is 1: 5～5: 1.
6, according to arbitrary compositions of claim 1 to 5, wherein contain Oleum Ricini.
7, according to arbitrary compositions of claim 1 to 6, wherein contain menthol.
8, a kind of compositions that contains releasing agent in methyl sulfonyl methane and a kind of physiologically-acceptable organic sulfhydryl body is used to prepare a kind of preparation and is used to prevent alopecia at least and stimulates natural on-off cycles of hair growth.
9, a kind of arbitrary compositions and complete blended preparation of physiologically acceptable carrier that contains claim 1 to 7 is used for preventing alopecia at least and stimulates natural on-off cycles of hair growth.
10, according to the preparation of claim 9, wherein said carrier contains Oleum Ricini.
11,, wherein contain methyl sulfonyl methane and sulfhydryl releasing agent and at least respectively be 0.5%w/w according to the preparation of claim 9 or 10 local usefulness.
12,, wherein contain methyl sulfonyl methane and sulfhydryl releasing agent 1～10%w/w respectively according to the preparation of claim 11.
13, according to the preparation of arbitrary part usefulness of claim 9 to 12, wherein contain menthol 1～30%w/w.
14, according to the oral formulations of claim 10, it is a unit dosage form, and per unit dosage contains methyl sulfonyl methane and each 50～500mg of sulfhydryl releasing agent.
15, a kind of method that is used for suppressing alopecia at least and stimulates natural on-off cycles of hair growth comprises the preparation of the claim 9 of using effective dose.
16, according to the method for claim 15, wherein the topical preparation with claim 11 imposes on skin.
17, according to the method for claim 16, wherein every day at least twice described topical preparation is imposed on scalp.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929218714A GB9218714D0 (en) | 1992-09-04 | 1992-09-04 | Synergistic compositions for hair restoration |
| AU49742/93A AU4974293A (en) | 1992-09-04 | 1993-09-03 | Synergistic compositions for hair restoration containing dimethylsulfone and a sulphydryl group releasing agent |
| PCT/GB1993/001871 WO1994005250A1 (en) | 1992-09-04 | 1993-09-03 | Synergistic compositions for hair restoration containing dimethylsulfone and a sulphydryl group releasing agent |
| CN94104273.1A CN1108527A (en) | 1992-09-04 | 1994-03-16 | Synergistic compositions for hair restoration |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929218714A GB9218714D0 (en) | 1992-09-04 | 1992-09-04 | Synergistic compositions for hair restoration |
| CN94104273.1A CN1108527A (en) | 1992-09-04 | 1994-03-16 | Synergistic compositions for hair restoration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1108527A true CN1108527A (en) | 1995-09-20 |
Family
ID=36954549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94104273.1A Pending CN1108527A (en) | 1992-09-04 | 1994-03-16 | Synergistic compositions for hair restoration |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN1108527A (en) |
| AU (1) | AU4974293A (en) |
| GB (1) | GB9218714D0 (en) |
| WO (1) | WO1994005250A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107550749A (en) * | 2017-10-15 | 2018-01-09 | 广州汀兰生物科技有限公司 | A kind of hair growth composition and its application |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3596900A (en) * | 1999-02-19 | 2000-09-04 | Marcus R. Jones | Method and composition for promoting hair growth |
| MXPA06009979A (en) * | 2004-03-02 | 2007-03-01 | Giuliani Spa | Composition for regulating the trophism of hair follicles and the cutaneous production of sebum and use thereof in androgenetic alopecia. |
| CN102698273A (en) * | 2004-12-24 | 2012-10-03 | 都菲斯特股份有限公司 | Formulations and treatments for trichology |
| EP1841505A4 (en) * | 2004-12-24 | 2010-01-27 | Dolphst Pty Ltd | Formula ions and treatments for well-being |
| GB2461021A (en) * | 2008-06-10 | 2009-12-23 | Ajit Lalvani | Composition for the treatment of hair loss and baldness |
| KR101124441B1 (en) * | 2009-11-23 | 2012-03-21 | 영남대학교 산학협력단 | Composition comprising the mixture of MAP and MSM for preventing baldness and improving hair growth |
| US8933119B2 (en) | 2011-01-03 | 2015-01-13 | The William M. Yarbrough Foundation | Method for treating phytophotodermatitis |
| US10640464B2 (en) | 2011-01-03 | 2020-05-05 | The William M. Yarbrough Foundation | Use of isothiocyanate functional surfactants as Nrf2 inducers to treat epidermolysis bullosa simplex and related diseases |
| US9962361B2 (en) | 2011-01-03 | 2018-05-08 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
| US11407713B2 (en) | 2011-01-03 | 2022-08-09 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
| US10308599B2 (en) | 2011-01-03 | 2019-06-04 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
| US11279674B2 (en) | 2011-01-03 | 2022-03-22 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactant and associated method of use |
| US10647668B2 (en) | 2011-01-03 | 2020-05-12 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactant and associated method of use |
| US10273205B2 (en) | 2011-01-03 | 2019-04-30 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating isothiocyanate functional surfactants and associated methods for treating biofilms |
| US8865765B2 (en) | 2011-01-12 | 2014-10-21 | The William M. Yarbrough Foundation | Method for treating eczema |
| US9532969B2 (en) | 2011-02-08 | 2017-01-03 | The William M. Yarbrough Foundation | Method for treating psoriasis |
| US9949943B2 (en) | 2012-07-26 | 2018-04-24 | The William M. Yarbrough Foundation | Method for treating neurodegenerative diseases |
| US10080734B2 (en) | 2012-07-26 | 2018-09-25 | The William M. Yarbrough Foundation | Method for treating autism and other neurodevelopmental disorders |
| US10434082B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms |
| US10441561B2 (en) | 2012-07-26 | 2019-10-15 | The William M. Yanbrough Foundation | Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer |
| WO2014018874A1 (en) | 2012-07-26 | 2014-01-30 | The William M. Yarbrough Foundation | Method for treating skin cancer |
| US10335387B2 (en) | 2012-07-26 | 2019-07-02 | The William M. Yarbrough Foundation | Method for treating infectious diseases with isothiocyanate functional compounds |
| US10434081B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Inhibitors of macrophage migration inhibitory factor |
| US9839621B2 (en) | 2012-07-26 | 2017-12-12 | The William M. Yarbrough Foundation | Method for treating bladder cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4296104A (en) * | 1979-08-30 | 1981-10-20 | Herschler R J | Therapeutic dimethyl sulfoxide composition and methods of use |
| US4296130A (en) * | 1979-08-30 | 1981-10-20 | Herschler R J | Methylsulfonylmethane and methods of use |
| GB8517299D0 (en) * | 1985-07-09 | 1985-08-14 | Salim A S M | Dermatologically active substances |
-
1992
- 1992-09-04 GB GB929218714A patent/GB9218714D0/en active Pending
-
1993
- 1993-09-03 WO PCT/GB1993/001871 patent/WO1994005250A1/en active Application Filing
- 1993-09-03 AU AU49742/93A patent/AU4974293A/en not_active Abandoned
-
1994
- 1994-03-16 CN CN94104273.1A patent/CN1108527A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107550749A (en) * | 2017-10-15 | 2018-01-09 | 广州汀兰生物科技有限公司 | A kind of hair growth composition and its application |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9218714D0 (en) | 1992-10-21 |
| AU4974293A (en) | 1994-03-29 |
| WO1994005250A1 (en) | 1994-03-17 |
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