KR100801164B1 - The compound for trichogenousness and preventing the depilation and cosmetic composition thereof - Google Patents

Abstract

A composition for preventing hair loss and promoting hair growth is provided to promote the hair growth by enhancing the activity of hair roots, provide the hair loss preventive effect, and make voluminous hair by increasing the thickness of the hair. A composition for preventing hair loss and promoting hair growth comprises a mixture including 30-60 wt.% of an extract of henna, 30-60 wt.% of a copper-peptide and 10-40 wt.% of a pyrrolidinyl diaminopyrimidine oxide, where the mixture is nano-size emulsified and solubilized. A method for preparing the composition comprises the steps of: (a) after mixing 10 wt.% of an extract of henna, 10 wt.% of a copper-peptide and 70 wt.% of purified water at room temperature, mixing 10 wt.% of a pyrrolidinyl diaminopyrimidine oxide therewith; (b) after mixing 5 parts by weight of ethanol, 3 parts by weight of myristyl alcohol, and 2 parts by weight of polyglycerylmethylglucesdistearate regarding 100 parts by weight of the mixture using an agi mixer, emulsifying the mixture using a homo mixer to obtain a milk-white emulsified state mixture; (c) dispersing the mixture obtained from the step(b) at a temperature of 20-35 deg.C using a micro fluidizer to prepare a transparent emulsion; and (d) after dissolving the emulsion in an aqueous solution containing 0.1-5.0 wt.% of a non-ionic surfactant, mixing well until the solution becomes transparent.

Description

Hair loss prevention and hair growth promoting composition, a method of manufacturing the same and a hair cosmetic composition using the same {The compound for trichogenousness and preventing the depilation and cosmetic composition

The present invention is a nanometer emulsion (Nano-size Emulsion, hereinafter referred to as nanoemulsion), and solubilization (Solubilization) to promote hair growth by the active ingredient contained in them, hair loss prevention and hair growth promotion to give a hair loss prevention effect The present invention relates to a composition, a preparation method thereof, and a hair cosmetic composition using the same.

Many attempts have been made to prevent hair loss and promote hair growth, including cosmetics, medicines and foods. For example, commercial articles containing the ingredients listed below are generally mentioned. Many of the ingredients mentioned in most products have been searched for in a way that can eliminate the cause of hair loss. In other words, hair growth promoters that are expected to act as anti-male hormones against testosterone involvement

Minoxidil (2,4-diamino-6-piperidinopyrimidine-3-oxide)

2.Tretinoin, Retinoid, 3. Diaxoxide, 4. Antiandrogen

 1) Topical,

  (1) Cyoctol

  (2) Progesterone

  (3) Estrogen

 2) Systemic

  (1) Spironolactone

  (2) Flutamide

  (3) Cimetidine

  (4) Ketoconazole

  (5) 5α-reductase inhibitors

  (6) oral contraceptives

5. Tricosaccharide (HOLTEN)

6.Pentadecanoic acid glyceride

7.Carponium chloride (3-Methoxycarbonylpropyl trimethylammonium chloride)

8. Trichopeptide: sulfopolysaccharide.

In addition, as a factor that promotes hair growth, a general tendency is suggested as summarized in the following table.

Action Effective ingredient Vasodilation  Blood stimulators Vitamin E, Vitamin E nicotinate, Glycoside Extract, Carpronium HCl, Benzyl nicotinate, γ-Oryzanol  Topical irritants Pepper tink, 1-menthol, camphor, benzylnicotinate thymol, ginger tink Nutrition  Vitamin Vitamin A, B ₁ , B ₂ , B ₆ , E and derivatives, Panthothenic acid and derivatives, Nicotinic acid, biotin  Amino acids Amino Acid Extract, cystine, Methionine, Cysteine, Serine, Leusine, Tryptophane Antidandruff  Keratin Salicylic acid, Resorcine, Resorcine monoacetate  Anti-seborrhea Sulfur, Pyridoxine Hydrochloride, Lecithine, Polysorbate  disinfectant Hinokitiol, Benzalkonium chloride, benzotium chloride, Chlohexithine, Isopropylmethyl phenol Hormone Female hormones (estradiol, ethinylestradiol) Anti-inflammatory Hydrocortisone saxetate, predinisolone, azulene, licorice and derivatives, hydrochloric acid diphenhydramine Metabolism, hair root function improvement and resurrection Panthothenylethylether, placenta ex, allantin, Penthadecanoic acid glyceride Moisturizer glycerine, hyaluronic acid, Chondroithine sulfate, 1,3-buthylene glycol

Many of the above-mentioned components can be explained as being determined by various mechanisms rather than as a single cause of various factors that affect hair growth and direct and indirect hair growth. The causes of hair loss can be summarized as follows.

(1) involvement of testosterone

Androgen metabolism occurs due to the involvement of various enzymes in the skin

In the hair, related metabolites such as testosterone, a male hormone produced by the prostate, and Androstendion formed by Androgen metabolism in the skin, enter the blood, reach the hair follicle cells, penetrate the cell membrane, and enter the cell. Testosterone introduced into the cytoplasm or produced by metabolism is transformed into 5α-Dehydrotestosterone (DHT) with stronger male hormone action by 5α-Reductase present in the cytoplasm. The 5α-DHT binds to specific receptors, enters the nucleus, fuses, affects the synthesis of proteins, and ultimately inhibits hair growth. In addition, 5α-DHT is an Adenyl cyclase activity that activates intracellular metabolism. Inhibits the supply of energy by lowering the metabolism of blasts by lowering the concentration of Cyclic ANP in cells

(2) impaired blood circulation around the nipple and follicle

Hair grows according to the division, proliferation, and differentiation of hair cells, and the water and nutrients necessary for the hair are supplied through capillaries spread around the milk cells. Therefore, the development of capillaries distributed around the nipple and follicles is a very important factor for hair growth.

(3) other causes

  ① Malnutrition

  ② Abnormalities and degradation of various enzyme activities involved in hair growth

  ③ sebaceous glands secretion of the sebaceous glands

  ④ excessive occurrence of dandruff (sebum secretion and growth factors of scalp bacteria) Inflammation of the epidermal cells compared to normal cells are denatured to keratinocytes early and peel. Desquamation of keratinocytes may cause pathological dandruff, which causes sebaceous membrane degeneration and decay products act on the hair follicles that communicate with the pores, altering hair follicle cells, and changing hair growth hairs to resting hairs. Therefore, the inflammation of the scalp needs to be removed quickly.

  ⑤ Excessive drying of the scalp

  ⑥ Scalp tension

  ⑦ Genetic factors.

However, the mechanisms used in the majority of commercial items have not reached a satisfactory level of hair loss prevention effect and hair growth effect.

The present invention is to solve the various problems as described above, an object of the present invention is to provide a method for producing a hair loss prevention and hair growth promoting composition easy to penetrate the scalp and skin.

Another object of the present invention is nanometer emulsion (Nano-size Emulsion) and solubilization (Solubilization) to promote hair growth by the active ingredient contained in them, hair loss prevention and hair growth promoting effect to prevent hair loss It is to provide a composition.

Still another object of the present invention is to provide a hair cosmetic composition having hair loss and hair growth promotion even when the hair loss prevention and hair growth promoting composition is used as a cosmetic.

Hair loss prevention and hair growth promoting composition of the present invention for achieving the above object is characterized in that henna extract (Henna Extract), copper-peptide (Copper peptide) and pyrrolidinyl diaminopyrimidine oxide (Pyrrolidinil diaminopyrimidine oxide) do.

Preferably, the hair loss prevention and hair growth promoting composition is a henna extract (Henna Extract), a copper peptide (Copper peptide) and pyrrolidinyl diaminopyrimidine oxide (Pyrrolidinil diaminopyrimidine oxide) are each mixed in a weight ratio of 1: 1: 1 It is characterized by.

In addition, the hair loss prevention and hair growth promoting cosmetic composition is a mixture of henna extract (Henna Extract), copper peptide (Copper peptide) and pyrrolididinil diaminopyrimidine oxide (0.01) with respect to the total weight of the cosmetic To 25.00 by weight.

Preferably, the cosmetic is characterized in that any one of shampoo, hair rinse, hair tonic, hair gel, hair lotion, hair pack, hair spray, hair mousse, hair treatment, hair dye.

Hereinafter, the present invention will be described in more detail.

Hair loss prevention and hair growth promoting composition of the present invention is prepared by mixing henna extract (Henna Extract), copper peptide (Copper peptide) and pyrrolidinyl diaminopyrimidine oxide (Pyrrolidinil diaminopyrimidine oxide).

Henna Extract is a powder made by drying the leaves of a plant known as Lawsoniainermis, which has a natural dyeing property called tannic acid, which is dried in the sun. It facilitates the care of the hair, neutralizes the scalp, suppresses excessive sebaceous secretion, prevents hair splitting, and gives hair elasticity and vivid color.

Such henna extract is mixed at 30 to 60% by weight based on the total weight of the composition to be mixed. At this time, when the henna extract is less than 30% by weight, it is difficult to be sure of the efficacy effect, and it is difficult to maintain stability when changing over time due to low viscosity, and when it is 60% by weight or more, it is difficult to mix the quality of the uniformity There is a disadvantage of safety due to the use of excessive amounts.

In addition, a copper peptide (copper peptide) is a series of three peptides bound to copper ions, and is a continuous extract of trace amounts from proteins in the human body. DHT (DHT), which inhibits 5-Reductase activity, weakens hair follicles and inhibits hair growth. It prevents hair loss by preventing the production of dihydrotestosterone.

Such copper-peptides are mixed at 30-60% by weight, based on the total weight of the composition being mixed. At this time, when the copper-peptide is less than 30% by weight, it is difficult to be sure of the efficacy effect, and it is difficult to maintain stability when changing according to the low viscosity.In the case of 60% by weight or more, the uniformity of quality is difficult to mix. There is a disadvantage of safety due to the use of excess content.

Pyrrolidinil diamino pyrimidine oxide, meanwhile, was developed by the US FDA as an antihypertensive drug for the first time, but it is a moisturizer that is similar to minoxidil and is also a safe moisturizer. The effect of promoting this is expected.

Such pyrrolidinyl diaminopyrimidine oxide (Pyrrolidinil diamino pyrimidine oxide) is mixed at 10 to 40% by weight based on the total weight of the composition to be mixed. At this time, when pyrrolidinyl diaminopyrimidine oxide (Pyrrolidinil diamino pyrimidine oxide) is less than 10% by weight, it is difficult to be sure of the efficacy effect, it is difficult to maintain stability when changing over time according to low viscosity, more than 40% by weight In this case, there is a disadvantage of safety due to the use of excessive content in the uniformity of the quality of the paste difficult to mix.

At this time, it is most preferable that each mixture is a henna extract: copper-peptide: pyrrolidinyldiaminopyrimidine oxide in a weight ratio of 1: 1: 1.

Meanwhile, a mixture of henna extract, copper peptide, and pyrrolididinil diaminopyrimidine oxide is 1.0 to 50 nanometers in a nano-emulsion (Nano-size Emulsion) and It can be used by solubilization. That is, the cell spacing of the skin is generally known as 75.0 nanometers is difficult to penetrate the skin when the size is larger than the size of the skin, while the smaller particles can be effective to easily penetrate the skin.

On the other hand, as a method of nanoemulsion and solubilization, 10% by weight of henna extract and 10% by weight of copper-peptide are mixed with 70% by weight of purified water, followed by mixing at room temperature and 10% by weight of pyrrolidinyldiaminopyrimidine oxide. . 5 parts by weight of ethanol, 3 parts by weight of myrist alcohol and 2 parts by weight of polyglyceryl methylglucose distearate (trade name Tegocare 450) based on the above mixture, the azi mixer at 1500 rpm. After mixing for 5 minutes, the homo mixer is emulsified at 1800 rpm for 3 minutes to obtain a milky white emulsified state. By using this cooler while maintaining a 20 to 35 degrees Celsius it is possible to obtain a transparent emulsion dispersed more than 1000 Bar twice with a high pressure mixer (Micro fluidizer). This transparent emulsion can be prepared by dissolving in an aqueous solution containing 0.1 to 5.0% by weight of a common nonionic surfactant and mixing well until it becomes transparent.

On the other hand, henna extract (Henna Extract), copper-peptide (Copper peptide) and pyrrolidinyl diaminopyrimidine oxide mixture according to the present invention is contained in a 0.01 to 25 weight ratio based on the total weight of the cosmetic Can be prepared. In this case, when the mixture exceeds 25 weight ratio, there is a problem that skin or scalp irritation due to excessive efficacy occurs.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, the scope of the present invention is not limited by the following examples.

<Example 1>

The magnetic bar was weighed at 5.00 and 10.0 parts by weight of each raw material (Comparative group: A-Henna extract, B-copper-peptide, C-pyrrolidinyldiaminopyrimidine oxide control group: butylene glycol) in 100 ml purified water. After dispersing for 5 minutes, select 40 free volunteers from 1 day, divide them into 4 groups of 10 people, divide them into 4 groups of control groups and control groups and apply shampoo daily for 2 weeks once a day for shampoo and rinsing. The total number of hairs obtained after 1 day low temperature drying of the discarded hairs and the growth stage (anagen, hereinafter A)-thin and small, catagen (hereinafter C)-thin, long hair, telogen (T) It was confirmed separately. For each of the three raw materials (henna extract, copper-peptide, pyrrolidinyldiaminopyrimidine oxide) the anti-hair loss effect was measured and the average amount of two weeks is shown in [Table 1].

<Example 2>

Each raw material (comparative group; D-Henna extract: copper-peptide 1: 1, E-Henna extract: pyrrolidinyldiaminopyrimidine oxide 1: 1, F-henna extract: copper-peptide: P) in 100 ml purified water Lolidinyldiaminopyrimidine oxide 1: 1: 1, control group: butylene glycol) was mixed by hand and treated in the same manner as in <Example 1> to confirm the hair loss prevention effect is shown together in [Table 1]. .

Henna extract: copper-peptide: pyrrolidinyldiaminopyrimidine oxide in combination (Comparative Group F) maximizes the hair loss prevention effect based on the results of confirming the hair loss prevention effect and the hair growth effect as shown in [Table 1]. Could know. However, the experimental period of 2 weeks was too short to effectively identify the hair growth effect.

<Example 3>

Henna extract: copper-peptide: pyrrolidinyldiaminopyrimidine oxide 1: 1: 1 was mixed in 100 ml purified water, and the sample prepared by mixing the azi mixer at 1500 rpm for 5 minutes was used as a control, and the homo mixer was 1500 rpm, After 5 minutes of mixing and dispersing the group to G, using a high pressure mixer (Micro fluidizer) to determine the sample dispersed 1000 Bar twice, H, 30 free volunteers were divided into three groups of 10 people after the control and Shampoo every day while dividing each sample once a day for 2 weeks for each sample, but extract the hair discarded at the time of shampoo and rinsing, and then, after low temperature drying for 1 day, the total number of hairs and anagen-small and small size , 2 weeks average amount of hair loss prevention effect and hair growth effect were measured for the sample dispersed and identified as catagen-thin long hair and telogen-thick long hair and are shown in [Table 2]. .

applicant  Control Comparative Group G Comparative group H Hair growth effect A C T A C T A C T  After 2 weeks One I'm 14 21 26 18 40 75 11 39 48 after 9 20 31 16 35 68 7 25 52 no difference 2 I'm 4 7 43 16 22 64 6 19 69 after 6 10 52 11 23 68 8 15 64 no difference 3 I'm 17 35 23 6 24 60 11 26 58 after 15 38 26 8 26 45 8 27 41 no difference 4 I'm 9 38 63 - 18 61 14 17 58 after 11 27 62 7 10 53 8 11 46 no difference 5 I'm 15 28 52 11 26 47 4 7 43 after 13 24 58 14 13 39 5 9 28 no difference 6 I'm 6 23 47 8 29 56 11 33 55 after 8 19 49 7 24 48 9 29 45 no difference 7 I'm 6 21 59 11 24 52 8 16 78 after 6 23 59 13 19 44 9 13 57 no difference 8 I'm 29 37 63 10 31 58 12 29 63 after 25 31 57 9 29 47 13 19 44 no difference 9 I'm 8 18 49 11 22 54 17 17 57 after 9 15 47 9 18 42 10 15 43 no difference 10 I'm 4 12 63 8 24 63 9 15 91 after 6 14 59 8 16 52 8 12 73 no difference

As shown in [Table 2], it was confirmed that the sample dispersed using a high pressure mixer (Micro fludizer) has an anti-hair loss effect.

<Example 4>

Henna extract: copper-peptide: pyrrolidinyldiaminopyrimidine oxide 1: 1: 1 was mixed in 100 ml purified water, and the azi mixer was mixed at 1500 rpm for 5 minutes as a control, and the homo mixer was 1500 rpm, The group to be mixed and dispersed for 5 minutes was set to G, and the sample which was dispersed twice with 1000 Bar using a high pressure mixer (Micro fluidizer) was determined as H. Then, 40 free volunteers were selected and divided into 4 groups of 10 people each. Dividing it into the comparison group (G, H), apply 2 weeks for each sample once a day. The total number of hairs obtained after 1 day low temperature drying by extracting hair discarded in shampoo and rinse before and after the experiment and the growth stage (anagen)-thin and small, the cageage-thin and long hair, telogen-thick The 8-week average amount of the hair loss preventing effect and the hair growth effect was measured and dispersed for the sample dispersed by checking with long hair, and the results are shown in [Table 3].

applicant  Control Comparative Group G Comparative group H Hair growth effect A C T A C T A C T  After 8 weeks One I'm 14 21 26 18 40 75 11 39 48 after 9 18 33 15 32 62 7 22 41 Effective 2 I'm 4 7 43 16 22 64 6 19 69 after 5 8 48 13 17 49 7 15 58 Effective 3 I'm 17 35 23 6 24 60 11 26 58 after 14 28 29 8 21 38 9 19 44 Effective 4 I'm 9 38 63 - 18 61 14 17 58 after 9 35 57 8 13 51 8 11 43 Effective 5 I'm 15 28 52 11 26 47 4 7 43 after 11 23 44 12 19 36 5 11 25 Effective 6 I'm 6 23 47 8 29 56 11 33 55 after 7 20 45 7 23 39 9 24 38 Effective 7 I'm 6 21 59 11 24 52 8 16 78 after 8 19 44 12 19 38 10 12 53 Effective 8 I'm 29 37 63 10 31 58 12 29 63 after 14 31 49 9 26 41 13 17 42 Effective 9 I'm 8 18 49 11 22 54 17 17 57 after 10 13 44 9 13 33 12 12 38 Effective 10 I'm 4 12 63 8 24 63 9 15 91 after 7 10 53 7 21 44 8 12 68 Effective

As shown in [Table 3], it was possible to confirm the hair regrowth effect on the sample dispersed using an azi mixer, a homo mixer, and a high pressure mixer (Micro fluidizer), and in order to exert an excellent hair regrowth effect, the mixed sample was a high pressure mixer ( It was found that the sample dispersed using the micro fludizer has a useful hair growth effect.

Example 5

Henna extract: copper-peptide: pyrrolidinyldiaminopyrimidineoxide 1: 1: 1 was mixed with 100ml purified water, and the sample dispersed in 600 bar twice using a high pressure mixer (Micro fluidizer) was obtained as I (control I). J) The sample dispersed twice with 800 Bar, the sample dispersed twice with 1000 Bar, K, and the sample dispersed twice with 1200 Bar were defined as L, and then enlarged 100,000 by scanning electron microscope (SEM) to improve the shape and size. After confirmation, 40 free volunteers were selected, divided into 4 groups of 10 people, divided into control group and comparison group (G, H) and applied for 2 weeks for each sample once a day. Measure the 8-week average amount of the particle size and hair growth effect by pressure of the high pressure mixer to determine how much the particle size of the sample dispersed using the micro fludizer is effective before and after the experiment. It is shown in [Table 4].

applicant  Control group I Comparative Group J Comparative Group K Comparative Group L Hair growth effect A C T A C T A C T A C T  After 2 weeks One I'm 8 30 75 11 22 48 9 23 59 6 21 59 after 7 26 51 9 23 31 8 21 44 7 20 41 Effective 2 I'm 7 23 66 12 28 52 11 26 67 4 7 53 after 7 25 49 9 22 29 9 17 43 5 15 44 Effective 3 I'm 9 31 69 14 36 47 7 17 47 17 35 43 after 6 28 44 8 26 27 7 19 41 9 23 43 Effective 4 I'm 11 38 65 16 35 71 8 33 42 14 16 55 after 9 29 53 10 25 48 8 19 40 8 18 41 Effective 5 I'm 13 45 64 4 28 59 22 19 63 15 47 34 after 11 31 57 6 21 36 13 15 42 9 27 41 Effective 6 I'm 13 36 56 12 29 68 13 33 61 4 12 63 after 10 30 41 9 28 43 10 20 47 6 20 47 Effective 7 I'm 20 37 63 19 31 58 12 29 63 11 18 71 after 21 27 47 13 23 41 9 15 49 9 15 55 Effective 8 I'm 8 18 49 11 22 54 17 17 57 8 20 58 after 9 21 33 6 19 47 11 13 42 7 18 48 Effective 9 I'm 13 39 52 11 28 47 15 21 54 8 17 82 after 11 26 29 9 18 41 9 11 39 9 15 62 Effective 10 I'm 6 23 47 8 29 56 11 33 55 4 16 84 after 8 22 33 7 14 42 8 20 38 6 23 63 Effective

According to Example 5, the optimum dispersed particle size was less than 50 nanometers, and the pressure condition of the high pressure mixer (Micro fludizer) was found to be 1000 Bar or more.

[Examples 6-13]

Henna extract: copper-peptide: pyrrolidinyldiaminopyrimidine oxide 1: 1: 1 solution in 100 ml of purified water was dispersed under two pressures of 1000 bar twice in a high pressure mixer (shampoo), hair rinse, The hair tonic, hair gel, hair lotion, hair pack, hair spray, hair mousse, and hair treatment were shown in [Table 13] to [Table 15], respectively.

<Example 6>

Henna extract: copper-peptide: pyrrolidinyldiaminopyrimidine oxide 1: 1: 1 in 100 ml purified water, and then mixed the sample with 1200 Bar twice using a high pressure mixer (Micro fluidizer). After prescribing according to the Sampu test prescription, 20 free applicants are selected and divided into 2 groups (control group, comparative group) of 10 people each day using 8 weeks for each sample once a day, but shampoo and rinsing are discarded. After the hair was collected by cold drying for 1 day, the total number of hairs obtained and the growth stage (anagen)-thin small size, catagen-thin long hair, telogen-thick long hair was identified.

Ingredient Name Control Comparison Water To 100 To 100 Ammonium Lauryl Sulfate 14.00 14.00 Sodium Laureth Sulfate 35.00 35.00 Cocamide DEA 0.60 0.60 Glycol distearate 1.20 1.20 Cocamidopropyl Betain 3.00 3.00 Sodium Chloride 0.50 0.50 Methylchloroisothiazolinone (and) Methylisothiazolinone 0.50 0.50 Dimethicone (and) Dimethiconol (and) Laureth-23 (and) Steareth-2 2.00 2.00 Polyquaternium-7 1.00 1.00 Henna Extract: Copper Peptide: Pyrrolidinyldiaminopyrimidine Oxide 1: 1: 1 - 10.0 Citric acid 0.10 0.10 Polysorbate 20 (and) Pantothenic Acid (and) Linoleic Acid (and) tocopheryl acetate 0.10 0.10 Perfume 0.25 0.25 Cololorants q.s q.s

<Example 7>

Henna extract: copper-peptide: pyrrolidinyldiaminopyrimidineoxide 1: 1: 1 in 100 ml purified water, and then mixed the sample at 1200 Bar twice using a high pressure mixer (Micro fluidizer). After formulating according to hairliner's test prescription, 20 free applicants were selected and divided into 2 groups (control group, comparative group) of 10 people each day using 8 weeks for each sample, shampoo and rinsing. After discarding the discarded hair for 1 day low-temperature drying, the total number of hair obtained and the growth stage (anagen)-thin small size, catagen-thin long hair, telogen-thick and long hair was identified.

Ingredient Name Control Comparison WATER To 100 To 100 Cetrimonium Chloride 5.00 5.00 Cetyl Alcohol 7.00 7.00 Isopropyl Mrystate 1.50 1.50 Disodium EDTA 0.05 0.05 Ceteareth-20 0.50 0.50 Methylchloroisothiazolinone (and) Methylisothiazolinone 0.05 0.05 Dimethicone (and) Dimethiconol (and) Laureth-23 (and) Steareth-2 3.00 3.00 Henna Extract: Copper Peptide: Pyrrolidinyldiaminopyrimidine Oxide 1: 1: 1 - 10.0 Hydrolyzed Keratin 0.10 0.10 Polysorbate 20 (and) Pantothenic Acid (and) Linoleic Acid (and) tocopheryl acetate 0.10 0.10 Perfume 0.20 0.20 Cololorants q.s q.s

<Example 8>

Henna extract: copper-peptide: pyrrolidinyldiaminopyrimidineoxide 1: 1: 1 in 100 ml purified water, and then mixed the sample with 1200 bar twice using a high pressure mixer (Micro fluidizer), was prepared as follows. After prescribing according to the hair gel test regimen, 20 free applicants were selected and divided into 2 groups (control group, comparative group) of 10 people and shampooed daily using 8 weeks for each sample once a day. After discarding the discarded hair for 1 day low-temperature drying, the total number of hair obtained and the growth stage (anagen)-thin small size, catagen-thin long hair, telogen-thick and long hair was identified.

Ingredient Name Control Comparison Wate To 100 To 100 Carbomer 1.00 1.00 1.3 Butylene Glycol 3.00 3.00 Glycerin 3.00 3.00 Disodium EDTA 0.05 0.05 Triethanolamine 99.0% 0.50 0.50 Sodium Hyauronate 1.00 1.00 Methyl Gluceth-20 Benzoate 1.00 1.00 Sodium Laureth-13 Carboxylate 0.50 0.50 Henna extract: copper-peptide: pyrrolidinyldiamino pyrimidine oxide 1: 1: 1 mixture - 10.0 Phenoxyethanol 0.40 0.40 Perfume 0.15 0.15 Cololorants q.s q.s

Example 9

Henna extract: copper-peptide: pyrrolidinyldiaminopyrimidine oxide 1: 1: 1 in 100 ml purified water, and then mixed the samples with 1200 bar twice using a high pressure mixer (Micro fluidizer). After prescribing according to the hair lotion test prescription, the shampoo and rinsing are carried out daily, using 20 free applicants, divided into 2 groups (control group, comparative group) of 10 people, using 8 weeks for each sample once a day. After discarding the discarded hair for 1 day low-temperature drying, the total number of hair obtained and the growth stage (anagen)-thin small size, catagen-thin long hair, telogen-thick and long hair was identified.

Ingredient Name Control Comparison Water To 100 To 100 Carbomer 0.55 0.55 1.3 Butylene Glycol 3.00 3.00 Disodium EDTA 0.05 0.05 Triethanolamine 99.0% 0.05 0.05 Sodium Hyauronate 0.30 0.30 PVP / VA 2.00 2.00 Quaternium 75 0.50 0.50 Henna extract: copper-peptide: pyrrolidinyldiamino pyrimidine oxide 1: 1: 1 mixture - 10.0 Phenoxyethanol 0.40 0.40 Perfume 0.15 0.15 Cololorants q.s q.s

<Example 10>

Henna extract: copper-peptide: pyrrolidinyldiaminopyrimidineoxide 1: 1: 1 in 100 ml purified water, and then mixed the sample at 1200 Bar twice using a high pressure mixer (Micro fluidizer). After prescribing according to the hair pack test prescription, 20 free applicants are selected and divided into 2 groups (control group, comparative group) of 10 people each day using 8 weeks for each sample once a day, but shampoo and rinsing are discarded. After the hair was collected by cold drying for 1 day, the total number of hairs obtained and the growth stage (anagen)-thin small size, catagen-thin long hair, telogen-thick long hair was identified.

Ingredient Name Control Comparison Water To 100 To 100 DL Panthenol 0.30 0.30 Allantoin 0.10 0.10 Disodium EDTA 0.05 0.05 Quaternium 77 0.50 0.50 Quaternium 78 0.50 0.50 Quaternium 75 1.00 1.00 Cetearyl Alcohol (and) Ceteareth-20 3.00 3.00 Dimethicone Copolyol 0.50 0.50 Propylene glycol 1.00 1.00 Henna extract: copper-peptide: pyrrolidinyldiamino pyrimidine oxide 1: 1: 1 mixture - 10.0 Phenoxyethanol 0.40 0.40 Perfume 0.25 0.25 Cololorants q.s q.s

<Example 11>

Henna extract: copper-peptide: pyrrolidinyldiaminopyrimidine oxide 1: 1: 1 in 100 ml purified water, and then mixed the sample with 1200 Bar twice using a high pressure mixer (Micro fluidizer). After prescribing according to the hair spray test prescription, 20 free applicants were selected and divided into 2 groups (control group, comparative group) of 10 people and shampooed daily using 8 weeks for each sample once a day. After discarding the discarded hair was confirmed by dividing the total number of hairs obtained after 1 day low-temperature drying and the growth stage (anagen)-thin and small size, catagen-thin long hair, telogen-thick and long hair.

Ingredient Name Control Comparison Cyclomethicone To 100 To 100 SD Alcohol 40B (Ethanol 99.0%) 30.00 30.00 water 2.00 2.00 C12-15 Alkyl Benzoate 7.00 7.00 Poloxamer 105 Benzoate 2.00 2.00 1.3 Butylene Glycol 1.00 1.00 PPG-3 Myristyl Ether 15.00 15.00 Henna Extract: Copper Peptide: Pyrrolidinyldiaminopyrimidine Oxide 1: 1: 1 - 10.0 Phenoxyethanol 0.30 0.30 Perfume 0.10 0.10 Cololorants q.s q.s

<Example 12>

Henna extract: copper-peptide: pyrrolidinyldiaminopyrimidineoxide 1: 1: 1 in 100 ml purified water, and then mixed the sample at 1200 Bar twice using a high pressure mixer (Micro fluidizer). After prescribing according to the hair mousse test prescription, 20 free applicants were selected and divided into 2 groups (control group, comparative group) of 10 people and shampooed daily using 8 weeks for each sample once a day. The discarded hair was collected, and then, after 1 day low temperature drying, the hairs were identified by dividing the total number of hairs into hairs, and the growth stage (anagen)-thin and small, catagen-thin and long hair, and the telogen-thick and long hair.

Ingredient Name Control Comparison Water To 100 To 100 Carbomer 0.50 0.50 Disodium EDTA 0.05 0.05 Allantoin 0.05 0.05 Keratine Hydrosate 0.10 0.10 Glycerin 3.00 3.00 propylene glycol 3.00 3.00 Triethanolamine 0.05 0.05 PEG-40 Hydrogenated Castor Oil 2.00 2.00 Cetanol 0.50 0.50 Henna extract: copper-peptide: pyrrolidinyldiamino pyrimidine oxide 1: 1: 1 mixture - 10.0 Phenoxyethanol 0.30 0.30 Perfume 0.20 0.20

Example 13

Henna extract: copper-peptide: pyrrolidinyldiaminopyrimidine oxide 1: 1: 1 in 100 ml purified water, and then mixed the sample with 1200 bar twice using a high pressure mixer (Micro fluidizer). After prescribing according to the hair treatment test prescription, 20 free applicants were selected and divided into 2 groups (control group, comparative group) of 10 people each day using shampoo and rinse daily for 8 weeks for each sample. After discarding the hair discarded at a low temperature for 1 day, the total number of hairs obtained and the growth stage (anagen)-thin small size, catagen-thin long hair, telogen-thick and long hair was identified.

Ingredient Name Control Comparison Water To 100 To 100 Carbomer 0.50 0.50 1.3 Butylene Glycol 3.00 3.00 Disodium EDTA 0.05 0.05 Triethanolamine 99.0% 0.05 0.05 PVP / VA 2.00 2.00 C1-5 Alkyl Galactomanan 2.50 2.50 C12-15 Alkyl Benzoate 5.00 5.00 Dioctyl Maleate 15.00 15.00 Mineral oil 21.00 21.00 Henna extract: copper-peptide: pyrrolidinyldiamino pyrimidine oxide 1: 1: 1 mixture - 10.0 Phenoxyethanol 0.30 0.30 Perfume 0.10 0.10 Cololorants q.s q.s

As described above, it is understood that the hair shampoo, hair rinse, hair tonic, hair gel, hair lotion, hair pack, hair spray, hair mousse, and hair treatment of Examples 9 to 16 exhibit excellent hair loss prevention and hair growth effects. Could.

As described above, the hair loss prevention and hair growth promoting composition according to the present invention promotes hair growth by an active ingredient contained in the nanometer emulsion (Nano-size Emulsion) and solubilization (Solubilization), and gives a hair loss prevention effect There is an advantage.

In addition, as a hair loss prevention and hair growth promoting composition to promote hair growth by promoting the activity of the hair root (Hair Root), not only to impair hair loss effect, but also to enhance the thickness of the hair cosmetics to make hair rich Can be prepared.

Claims (9)

Henna extract (Henna Extract), copper-peptide (Copper peptide) and pyrrolidinyl diaminopyrimidine oxide (Pyrrolidinil diaminopyrimidine oxide) is characterized in that the hair loss prevention and hair growth promoting composition comprising a mixture. The method of claim 1, wherein the hena extract (Henna Extract), copper peptide (Copper peptide) and a mixture of Pyrrolididinil diaminopyrimidine oxide is a mixture of 1.0 to 50 nanometers (Nano-size Hair loss prevention and hair growth promoting composition, characterized in that the Emulsion) and solubilization. The method according to claim 1 or 2, wherein the henna extract, copper-peptide, and pyrrolidinyl diaminopyrimidine oxide are 30 to 60% by weight, 30 to 60, respectively. Hair loss prevention and hair growth composition, characterized in that mixed by weight, 10 to 40% by weight. The method of claim 3, wherein the henna extract (Henna Extract), copper peptide (Copper peptide) and pyrrolidinyl diaminopyrimidine oxide (Pyrrolidinil diaminopyrimidine oxide) is characterized in that each mixed in a weight ratio of 1: 1: 1 Hair loss prevention and hair growth promoting composition. A first step of mixing 10% by weight of henna extract and 10% by weight of copper-peptide in 70% by weight of purified water, followed by mixing at room temperature, and then mixing 10% by weight of pyrrolidinyldiaminopyrimidine oxide; 5 parts by weight of ethanol, 3 parts by weight of myrist alcohol and 2 parts by weight of polyglyceryl methylgluses distearate based on 100 parts by weight of the mixture of the first step, followed by emulsification with a homo mixer. To obtain a milky white emulsified state; A third step of dispersing the mixture of the second step in a high pressure mixer (Micro fluidizer) while maintaining 20 to 35 degrees Celsius; A fourth step of dissolving the transparent emulsion in an aqueous solution containing 0.1 to 5.0 wt% of a nonionic surfactant and mixing well until it becomes transparent; Method for producing a hair loss prevention and hair growth promoting composition comprising a. Hena extract (Henna Extract), copper peptides (Copper peptide) and a mixture of Pyrrolidinil diaminopyrimidine oxide (Pyrrolidinil diaminopyrimidine oxide) containing 0.01 to 25.00 parts by weight based on 100 parts by weight of cosmetics Cosmetic composition. The hair cosmetic product of claim 6, wherein a mixture of the henna extract, the copper peptide, and the pyrrolididinil diaminopyrimidine oxide is 0.01 to 5.00 weight ratio, respectively. Composition. According to claim 6 or 7, wherein the henna extract (Henna Extract), copper-copper (Copper peptide) and a mixture of Pyrrolidinil diaminopyrimidine oxide (30) each based on the mixed weight 30 to 60% by weight, 30 to 60% by weight, hair cosmetic composition, characterized in that mixed in 10 to 40% by weight. The hair cosmetic composition of claim 8, wherein the cosmetic is any one of shampoo, hair rinse, hair tonic, hair gel, hair lotion, hair pack, hair spray, hair mousse, hair treatment, and hair dye.