CN113069390A - Anti-hair-loss hair-growing lotion and preparation method thereof - Google Patents
Anti-hair-loss hair-growing lotion and preparation method thereof Download PDFInfo
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- 230000003656 anti-hair-loss Effects 0.000 title claims abstract description 27
- 239000006210 lotion Substances 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 210000004209 hair Anatomy 0.000 claims abstract description 45
- 201000004384 Alopecia Diseases 0.000 claims abstract description 43
- 231100000360 alopecia Toxicity 0.000 claims abstract description 23
- 229940094952 green tea extract Drugs 0.000 claims abstract description 12
- 235000020688 green tea extract Nutrition 0.000 claims abstract description 12
- TTWYZDPBDWHJOR-IDIVVRGQSA-L adenosine triphosphate disodium Chemical compound [Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O TTWYZDPBDWHJOR-IDIVVRGQSA-L 0.000 claims abstract description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 27
- 238000003756 stirring Methods 0.000 claims description 21
- 230000003676 hair loss Effects 0.000 claims description 20
- 208000024963 hair loss Diseases 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 19
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 230000003779 hair growth Effects 0.000 claims description 16
- 241001289529 Fallopia multiflora Species 0.000 claims description 11
- 238000001816 cooling Methods 0.000 claims description 10
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 6
- 229960005323 phenoxyethanol Drugs 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
- 244000269722 Thea sinensis Species 0.000 claims description 4
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
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- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The invention discloses an anti-hair-loss and hair-growing lotion which adopts green tea extract to improve blood circulation, promote the proliferation of human hair follicle papilla cells and prolong the cell cycle, thereby promoting the growth of hair. In addition, it can prevent testosterone from converting into dihydrotestosterone, and prevent alopecia caused by androgen excess. The disodium adenosine triphosphate has the function of improving the metabolism of the organism, participates in the metabolism of fat, protein, sugar, nucleic acid and nucleotide in the body, and is also a source of energy in the body. The green tea extract can be used for assisting and strengthening the effect of promoting the proliferation of hair follicle hair papilla cells and promoting the growth of scalp hair follicles. The fleece-flower root and the Chinese arborvitae twig which contain trace element copper can stimulate the growth of hair follicles of scalp to make the hair grow more densely. Also discloses a preparation method of the hair restorer, which is simple and stable.
Description
Technical Field
The invention relates to the field of cosmetics, and particularly relates to anti-hair loss and hair-growing lotion and a preparation method thereof.
Background
With the continuous development of economy and society, the number of people who lose hair in the whole society is increasing. Even after 90 a lot of hair loss began to appear. The leading cause of hair loss is genetic, but many young people now lose hair earlier and more severely than their elders. Alopecia has become a serious problem for many people.
Modern studies have shown that hair follicles in the human scalp are the site of hair growth, providing nutrients to the hair. In the case of normal hair follicle function, the growth process of hair can be roughly divided into anagen, catagen and telogen phases. Among them, hair papilla cells of hair follicles control the development of hair follicles and the growth of hairs. The hair follicle in the growth phase has a completely developed vascular tissue, hair bulb cells at the root of the hair are exuberant to divide, and the generated new cells can continuously move upwards to fill the body of the hair, so that the normal growth of the hair is facilitated. When the hair follicle enters the end of the growth period, the hair stem stops growing, the hair follicle begins to shrink, hair papilla cells become small, the hair stops growing and enters the degeneration period, then the hair follicle enters the resting period, the blood vessel tissues around the hair follicle disappear, and finally the hair is shed. Thus, the growth and apoptosis of hair follicles have a significant effect on hair loss.
Traditional Chinese medicine considers that the effect of treating alopecia is mainly on consolidating the constitution. The kidney stores essence, governs bone and produces marrow, and manifests itself in hair. "Hair nutrition comes from blood and grows from kidney qi. The beard and hair of human being are the balance of blood and the kidney. Kidneys store essence, livers store blood, and the sources of both yin and yang are the same, so essence and blood are generated mutually, essence is full of blood, and nourishes, and the recipe can make beard and hair black and firm and non-shedding roots.
Tea leaf extract is often added to hair cosmetics abroad to regulate hair growth as a means for preventing alopecia. The main reason is that tea extract can promote the proliferation of human hair follicle papilla cells cultured in vitro and delay apoptosis, thereby prolonging the growth phase of hair (Kwon et al, phytomedine 14(2007), p.551-555). Japanese patent JP2005170927A discloses a hair tonic mainly comprising tea leaf extract as a main active ingredient. Korean patent KR20140123922A discloses a cosmetic composition comprising tea leaf extract for treating alopecia areata, alopecia and promoting hair growth. According to traditional Chinese medicine, the Chinese arborvitae twig can grow hair and blacken hair, and the polygonum multiflorum can tonify liver and kidney, benefit essence and blood and blacken beard and hair. Therefore, in the patent of using Chinese herbs to prevent alopecia, two herbs of Ce Bai Ye and He shou Wu are commonly used. Chinese patent CN108245653A discloses a Chinese medicinal anti-hair loss pilatory, which mainly comprises cacumen biotae as the main component. Chinese patent CN103393830A discloses an external Chinese medicinal preparation for preventing hair loss and promoting hair growth, which takes cacumen Platycladi and radix Polygoni Multiflori Preparata as main components.
The above-mentioned patents and documents show that tea extract, cacumen biotae extract, polygonum multiflorum extract and the like have the ability to prevent hair loss and promote hair growth. However, the above patent is mainly used for treating alopecia by western medicine or traditional Chinese medicine, and does not relate to a treatment method combining Chinese and western medicine. Therefore, the combination of the treatment methods of the traditional Chinese medicine and the western medicine has important significance for more comprehensively preventing and treating the alopecia.
Disclosure of Invention
The invention comprehensively considers the effective components commonly used by traditional Chinese medicine and western medicine for treating alopecia, and aims to provide the alopecia preventing and hair growing lotion which takes the green tea extract, the cacumen biotae extract and the polygonum multiflorum extract as main components for preventing alopecia and growing hair and also takes disodium adenosine triphosphate to provide energy for cell proliferation, accelerate hair growth and achieve the effect of promoting hair growth. The invention also aims to provide a preparation method of the anti-hair-loss and hair-growing water.
In order to achieve the first object, the invention adopts the following design scheme:
the anti-hair-loss hair-growing liquid comprises the following components in percentage by mass:
preferably, the composition comprises the following components in percentage by mass:
preferably, the composition comprises the following components in percentage by mass:
preferably, the green tea extract is a brownish red powdery substance, wherein the content of tea polyphenol is not less than 95%.
Preferably, the sodium hyaluronate is white powdery substance, wherein the content of active substances is not less than 99%, and the average molecular weight is 5 kDa.
Preferably, the cacumen biotae extract is a water-soluble brown transparent liquid with the solid content of 24 percent.
Preferably, the polygonum multiflorum extract is water-soluble brown transparent liquid with the solid content of 18 percent.
Preferably, the disodium adenosine triphosphate is white powder or crystalline substance, wherein the content of the effective component is not less than 95%.
0.3-0.6% of phenoxyethanol as a preservative and 0.02-0.3% of sodium hydroxide as a pH regulator are also added into the anti-hair loss and hair growth promoting water.
In order to achieve the second object, the invention adopts the following technical scheme:
a method for preparing the anti-hair-loss hair-growing water comprises the following steps:
1) adding deionized water and 1, 3-butanediol into a reaction kettle, starting stirring, heating to 80-85 ℃, and uniformly stirring and dispersing.
2) And (3) starting cooling circulating water, stirring and cooling, adding the green tea extract, the sodium hyaluronate, the cacumen biotae extract, the polygonum multiflorum extract, the disodium adenosine triphosphate and the phenoxyethanol into a reaction pot when the temperature is reduced to 40-45 ℃, homogenizing for 5-10 minutes, and stirring at constant temperature after the homogenization is finished until the solution is transparent and uniform.
3) Adding sodium hydroxide into a reaction kettle, and stirring at constant temperature until the sodium hydroxide is completely dissolved.
4) And continuously stirring and cooling to below 40 ℃, stopping stirring and discharging.
The green tea extract is effective in improving blood circulation, promoting proliferation of papilla cells of hair follicle, and prolonging cell cycle, thereby promoting hair growth. In addition, it can prevent testosterone from converting into dihydrotestosterone, and prevent alopecia caused by androgen excess.
The cacumen biotae extract has the effects of cooling blood, stopping bleeding, promoting hair growth and blackening hair. It also has effects in promoting local blood circulation, improving metabolism of hair follicle, removing dandruff, and promoting hair regeneration, and can be used for treating seborrheic alopecia.
The Polygoni Multiflori radix extract has effects of nourishing liver and kidney, replenishing essence and blood, blackening hair and beard, and strengthening tendons and bones. It contains trace copper element, and can stimulate hair follicle growth to make hair grow thicker.
The adenosine disodium triphosphate has the function of improving the metabolism of organisms, participates in the metabolism of fat, protein, sugar, nucleic acid and nucleotide in vivo, and is also a source of energy in vivo. The anti-hair loss and hair growth promoting lotion is mainly used for enhancing the effect of the green tea extract on promoting the proliferation of hair follicle papilla cells and promoting the growth of scalp hair follicles.
Detailed Description
The anti-hair loss and hair-growing water provided by the invention is prepared by taking green tea extract, cacumen biotae extract, polygonum multiflorum extract and adenosine disodium triphosphate as main components and assisting with a humectant, a preservative, a pH regulator and water commonly used in cosmetics. The present invention will be described below by way of examples, but the present invention is not limited thereto.
Example 1
Alopecia preventing and hair growing liquid:
the anti-hair-loss hair-growing water comprises the following components in percentage by weight:
| component (percentage) | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 |
| Deionized water | 85.667 | 88.017 | 89.117 | 86.717 | 88.617 |
| 1, 3-butanediol | 0.5 | 1 | 2.5 | 3 | 2 |
| Green tea extract | 2 | 0.8 | 1 | 1.5 | 0.4 |
| Hyaluronic acid sodium salt | 0.15 | 0.5 | 0.2 | 0.1 | 0.3 |
| Cacumen Platycladi extract | 7 | 6 | 4 | 5 | 5 |
| Polygonum multiflorum extract | 4 | 3 | 2.5 | 3 | 3 |
| Adenosine disodium triphosphate | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 |
| Phenoxyethanol | 0.35 | 0.35 | 0.35 | 0.35 | 0.35 |
| Sodium hydroxide | 0.033 | 0.033 | 0.033 | 0.033 | 0.033 |
The preparation method of the anti-hair-loss hair-growing liquid comprises the following steps: adding deionized water and 1, 3-butanediol into a reaction kettle, starting stirring, heating to 80-85 ℃, and uniformly stirring and dispersing; starting cooling circulating water, stirring and cooling, adding the green tea extract, the sodium hyaluronate, the cacumen biotae extract, the polygonum multiflorum extract, the disodium adenosine triphosphate and the phenoxyethanol into a reaction pot when the temperature is reduced to 40-45 ℃, homogenizing for 5-10 minutes, and stirring at constant temperature after homogenizing is finished until the solution is transparent and uniform; adding sodium hydroxide into a reaction kettle, and stirring at constant temperature until the sodium hydroxide is completely dissolved. And continuously stirring and cooling to below 40 ℃, stopping stirring and discharging.
The present invention is not limited to the above-described embodiments, which are described in the specification and illustrated only for illustrating the principle of the present invention, but various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which are also within the scope of the present invention as claimed. The scope of the invention is not to be defined by the appended claims and their equivalents.
EXAMPLES evaluation of Effect
Clinical experiments were carried out with the hair loss preventing and growing liquid provided in example 5
Application method of anti-hair-loss hair-growing liquid
After being cleaned, the hair is wiped dry, a proper amount of essence is uniformly smeared on the scalp, and the serious alopecia or the sparse hair part is massaged in a looping mode.
Stability survey
The anti-hair-loss hair-growing liquid is placed in a-15 ℃, 45 ℃, room temperature and illumination box, and the stability of the anti-hair-loss hair-growing liquid in a-15-45 ℃ cold and hot circulation box is inspected for 1 month, and the result shows that the anti-hair-loss hair-growing liquid passes the stability inspection.
Evaluation of efficacy of alopecia preventing and hair growth promoting solution
And (3) experimental design: based on the principles of random, double-blind and self-control, the anti-hair loss essence is used every other day, follow-up visits are carried out on days 0, 14 and 28, and the hair loss counting and scalp oil content testing are carried out on each subject before use and at each follow-up visit. The subject continuously uses the product for 9 months, and the efficacy test comprises measuring the hair growth effect by a hair image measuring instrument respectively at 0 month, 3 months, 6 months and 9 months; determining the ability to reduce hair loss; the visual perception of the volunteers using the product is quantified.
The subjects have alopecia conditions of different degrees between the ages of 30-55, and 1mL of essence water is used in the morning and at night every day for 9 months continuously. Measurements were taken before and after 3 months, 6 months and 9 months of use. Hair growth effect was measured using a hair image measuring instrument (a standardized ultra-close camera study method) in combination with automated image analysis.
Test conditions
Environmental conditions: the temperature is 25 +/-1 ℃, and the relative humidity is 50 +/-3%.
The tested part: a head portion.
And analyzing the content of the scalp oil. The sebum test is based on quartz crystal sensor technology, and the sebum quality is collected from the skin by a sensor. The greater the mass of sebum, the greater the sebum content. The smaller the value, the lower the sebum content, and the better the oil control effect of the product.
Hair loss count: the shed hair from each subject was collected by a screen and counted.
The results of the hair loss and growth preventing water test are shown in tables 1 and 2.
TABLE 1 oil and fat content with time table
After the hair loss preventing and growing lotion is used, the oil content of the tested part is gradually reduced. The reduction in the visits of D14 and D28 was 11.1% and 25.4% respectively compared with D0. Therefore, the anti-hair-loss and hair-growing water has the oil control effect.
TABLE 2 Table of the number of hair drops as a function of time
After the hair loss preventing and hair growing lotion is used, the number of the hair loss is reduced. The reduction in the visits of D14 and D28 was 6.06% and 17.4% respectively compared with D0. Thus, the alopecia preventing shampoo and the alopecia preventing essence have an alopecia preventing effect. In the questionnaire and feedback of the subjects, 64% of the subjects considered that the hair loss was significantly reduced, and 36% of the subjects considered that the hair loss was slightly reduced; the fat secretion was considered to be significantly reduced in 8% of subjects, moderately reduced in 36% of subjects, and slightly reduced in 32% of subjects.
In conclusion, according to the research on Chinese herbal medicines and other active matters, the anti-hair-loss hair-growing liquid is prepared by screening effective active ingredients, and the product has good stability. By adopting a human body test method, through the scalp grease content, the hair loss count and the self evaluation of the testee, the hair loss of the testee is reduced, the grease content is reduced, and the testee feels grease and alopecia. The improvement is achieved. The result shows that the anti-hair-loss and hair-growing water is used simultaneously and has good oil-control anti-hair-loss effect.
In conclusion, the hair loss preventing and hair growing product has remarkable hair loss preventing and hair growing effects.
Claims (10)
1. The anti-hair-loss hair-growing liquid is characterized by comprising the following components in percentage by mass:
2. the anti-hair-loss hair tonic according to claim 1, characterized in that the composition comprises the following components by mass percent:
3. the anti-hair-loss hair tonic according to claim 1, characterized in that the composition comprises the following components by mass percent:
4. the alopecia preventing and hair growing liquid as claimed in claim 1, 2 or 3, wherein the green tea extract is a brownish red powdery substance having a tea polyphenol content of not less than 95%.
5. The anti-hair loss and hair growth lotion according to claim 1, 2 or 3, wherein the sodium hyaluronate is white powdery substance, the active content is not less than 99%, and the average molecular weight is 5 kDa.
6. The hair-loss preventing and hair-growing liquid as claimed in claim 1, 2 or 3, wherein the cacumen biotae extract is a water-soluble brown transparent liquid with a solid content of 24%.
7. The anti-hair-loss and hair-growing liquid as claimed in claim 1, 2 or 3, wherein the polygonum multiflorum extract is a water-soluble brown transparent liquid with a solid content of 18%.
8. The hair-loss preventing and hair-growing liquid as claimed in claim 1, 2 or 3, wherein the disodium adenosine triphosphate is white powder or crystalline substance, and the content of effective components is not less than 95%.
9. The hair restoring and growing liquid as claimed in claim 1, 2 or 3, further comprising phenoxyethanol 0.3-0.6% as preservative and sodium hydroxide 0.02-0.3% as pH regulator.
10. A method for preparing the alopecia preventing and hair growing water as defined in any one of claims 1 to 9, which comprises the steps of:
1) adding deionized water and 1, 3-butanediol into a reaction kettle, starting stirring, heating to 80-85 ℃, and uniformly stirring and dispersing.
2) And (3) starting cooling circulating water, stirring and cooling, adding the green tea extract, the sodium hyaluronate, the cacumen biotae extract, the polygonum multiflorum extract, the disodium adenosine triphosphate and the phenoxyethanol into a reaction pot when the temperature is reduced to 40-45 ℃, homogenizing for 5-10 minutes, and stirring at constant temperature after the homogenization is finished until the solution is transparent and uniform.
3) Adding sodium hydroxide into a reaction kettle, and stirring at constant temperature until the sodium hydroxide is completely dissolved.
4) And continuously stirring and cooling to below 40 ℃, stopping stirring and discharging.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115944571A (en) * | 2023-01-10 | 2023-04-11 | 河北纳科生物科技有限公司 | Essence spray for promoting hair growth and repairing hair roots and preparation method thereof |
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| KR20140114492A (en) * | 2013-03-14 | 2014-09-29 | 방기호 | Composition from natural material for hair loss or hair growth effect |
| CN105919900A (en) * | 2016-06-27 | 2016-09-07 | 北京普世安生物科技有限公司 | Hair re-growing and hair loss preventing shampoo and preparation method thereof |
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| CN1456212A (en) * | 2003-01-15 | 2003-11-19 | 邬纯忠 | External applied preparation preparing method for hairing and nourishing hair |
| KR20140114492A (en) * | 2013-03-14 | 2014-09-29 | 방기호 | Composition from natural material for hair loss or hair growth effect |
| CN105919900A (en) * | 2016-06-27 | 2016-09-07 | 北京普世安生物科技有限公司 | Hair re-growing and hair loss preventing shampoo and preparation method thereof |
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| CN115944571B (en) * | 2023-01-10 | 2024-04-02 | 河北纳科生物科技有限公司 | Essence spray for promoting hair growth and repairing hair roots and preparation method thereof |
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