CN110393681A - A kind of pure plant washes shield composition - Google Patents
A kind of pure plant washes shield composition Download PDFInfo
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- CN110393681A CN110393681A CN201810379879.3A CN201810379879A CN110393681A CN 110393681 A CN110393681 A CN 110393681A CN 201810379879 A CN201810379879 A CN 201810379879A CN 110393681 A CN110393681 A CN 110393681A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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Abstract
The invention discloses a kind of pure plants to wash shield composition, including following component: thyme, frutus cnidii, the fruit of summer cypress, folium artemisiae argyi, the fleece-flower root, tea seed cake, cacumen biotae, lavender, gleditsia sinensis.Property of the present invention is mild and safe and efficient, non-stimulated to skin, promotes skin blood circulation, activating cell, functions of nourishing hair and growing hair, effectively reduces alopecia, and profit sends out anti-dandruff, makes that hair is submissive, glossy black and high resilience.
Description
Technical field
The invention belongs to technical field of having one's hair wash and take care of hair, in particular to a kind of pure plant washes shield composition.
Background technique
Wash shield product include shampoo, hair conditioner, Essence, nutrition is spraying, hair gel, hair film, pomade, hair jelly, washes one's hair
Bath foam, hand cleanser etc. are a kind of articles for daily use indispensable in people's life, as the improvement of people's living standards, full
Enough while most basic requirement for cleaning, people more focus on the maintenance to hair quality, scalp and skin;It focuses more on and washes shield production
The quality of product and influence to personal health.Possess pitch-black soft bright, healthy and flexible hair and skin is each
The hope of people seeking beauty.
It is various that shield product variety is washed currently on the market, but its most prescription be unable to do without various surfactants, silicon
Oil, cation opsonizing agent, essence, etc. a few bulk chemicals, cleaning degreasing effect of these chemical substances, to pore with
Skin brings stimulation and injury, and the sebum film that skin generates naturally is excessively cleaned, the defence capability of skin itself is reduced,
Phenomena such as causing epifolliculitis, dermatitis, itch, skin aging, or even have and lead to cell mutation, carcinogenic equal side effects.Chemistry is used
Product are obvious to all to the injury of human body, so people increasingly refuse chemical addition agent now, pursue and return naturally.Cause
This contain natural plant component, rich in nutrition, it is safe and non-toxic wash shield product, regain China's essence of Traditional Chinese medicine health-preserving in 5000
Marrow starts active Chinese drug component health hair care, activating cell, the healthy new concept for nourishing skin, has catered to broad masses of the people's
The consumption demand of health.
Summary of the invention
In order to solve the above-mentioned technical problem, the purpose of the present invention is to provide a kind of pure plants to wash shield composition, property
Matter is mild and safe and efficient, non-stimulated to skin, and skin blood circulation, activating cell is promoted to effectively reduce alopecia, and profit hair is gone
It considers to be worth doing, make that hair is submissive, glossy black and high resilience.
In order to achieve the above technical purposes, reach above-mentioned technical effect:
One aspect of the present invention provides a kind of pure plant and washes shield composition, including following component: thyme, cnidium monnieri
Son, the fruit of summer cypress, folium artemisiae argyi, the fleece-flower root, tea seed cake, cacumen biotae, lavender, gleditsia sinensis.
Further, it further includes green-tea extract, radix-polygoni multiflori extract that the pure plant, which washes shield composition,.
Further, it further includes Ginger P.E that the pure plant, which washes shield composition,.
Further, the pure plant washes shield composition, and the weight proportion of each component is as follows: thyme 10-15
Part, 6-10 parts of frutus cnidii, 5-8 parts of the fruit of summer cypress, 6-10 parts of folium artemisiae argyi, 10-15 parts of the fleece-flower root, 15-20 parts of tea seed cake, cacumen biotae 5-8
Part, 6-10 parts of lavender, 5-10 parts of gleditsia sinensis.
Further, the pure plant washes shield composition, and the weight proportion of each component is as follows: thyme 10-15
Part, 6-10 parts of frutus cnidii, 5-8 parts of the fruit of summer cypress, 6-10 parts of folium artemisiae argyi, 10-15 parts of the fleece-flower root, 15-20 parts of tea seed cake, cacumen biotae 5-8
Part, 6-10 parts of lavender, 5-10 parts of gleditsia sinensis, 3-8 parts of green-tea extract, 4-10 parts of radix-polygoni multiflori extract.
Further, the pure plant washes shield composition, and the weight proportion of each component is as follows: thyme 10-15
Part, 6-10 parts of frutus cnidii, 5-8 parts of the fruit of summer cypress, 6-10 parts of folium artemisiae argyi, 10-15 parts of the fleece-flower root, 15-20 parts of tea seed cake, cacumen biotae 5-8
Part, 6-10 parts of lavender, 5-10 parts of gleditsia sinensis, 3-8 parts of green-tea extract, 4-10 parts of radix-polygoni multiflori extract, Ginger P.E 3-6
Part.
Another aspect of the present invention, it is a kind of according to pure plant wash shield composition be prepared into wash shield product.
Above-mentioned shield product of washing is prepared by following methods:
Step 1: taking the thyme accordingly matched, folium artemisiae argyi and lavender that 5 times of amount distilled water are added first, use vapor
The way of distillation extracts aromatic oil, and once to get volatile oil, sealing is spare for rectifying again for gained aromatic oil;
Step 2: Xiang Suoshu step 1 mentions in the dregs of a decoction after oil and puts into the frutus cnidii accordingly matched, the fruit of summer cypress, the fleece-flower root, tea
The dregs of rice, cacumen biotae and gleditsia sinensis, be then respectively adding 6 times, 4 times, 3 times of amounts distillation water heating extractings three times, extraction time is respectively
2hr, 1.5hr, 1hr are concentrated under reduced pressure, and up to extract powder after spray drying, sealing is spare;
Step 3: the aromatic oil and the extract powder being mixed, is prepared into and described washes shield product.
Further, the shield product of washing includes that shampoo, hair conditioner, Essence, nutrition is spraying, hair gel, hair
Any one in film, pomade, hair jelly, bath foam and hand cleanser.
The effect of each component, is as follows in public affairs of the invention:
Thyme: promoting blood circulation, strengthen immunity, mitigates neuropathic pain, antibacterial analgesic.Activating brain cell mentions
Memory and attention are risen, dandruff is eliminated, inhibits to shave one's head.
Frutus cnidii: warm-natured, bitter.Eliminating dampness, wind-dispelling, desinsection, warming kidney and enhancing body.For impotence, palace cold, morbid leucorrhoea duye, arthritis with fixed pain caused by dampness
Pain in the loins;Eczema of vulva, married woman's pruritus vulvae, trichomonas vaginitis are controlled outside, alopecia seborrheica can be treated, antipruritic effect is very prominent.
The fruit of summer cypress: acrid flavour, hardship, it is cold in nature.Return kidney, bladder meridian.Clearing heat and promoting diuresis, dispelling wind and arresting itching.For difficulty and pain in micturition, pruritus vulvae
Leukorrhagia, rubeola, eczema, pruitus.Containing triterpenoid saponin abundant, fat oil, alkaloid, flavones etc..And " triterpenoid saponin " has
Persistence is a kind of good natural surfactant like the foam of soap solution, can be cleaned hair with dispelling wind and arresting itching, be gone
Dandruff makes hair keep pitch-black glossy, reparation damaged hair, supplements nutrient to hair.
Folium artemisiae argyi: it is bitter, pungent, warm, return liver,spleen,kidney to pass through.Warming channel for arresting bleeding, eliminating cold to stop pain;External application removing dampness to stop itchin.For few abdomen
Crymodynia, uterus cold infertile uncomfortable through trembling with fear are spitted blood, bleeding from five sense organs or subcutaneous tissue, metrorrhagia and metrostaxis, menorrhalgia, blood under vaginal bleeding during pregnancy;Pruitus is controlled outside.Also have
Go intermittent headache (headache), deoil, be antipruritic, is anti-dandruff, Anti-hair loss the effects of.
The fleece-flower root: bitter, sweet, puckery, tepor.Return liver, the heart, kidney channel.Nourishing liver and kidney, beneficial menses, black beard and hair, strengthening the bones and muscles are changed turbid
Lipid-loweringing.For blood deficiency chlorosis, dizziness and tinnitus, poliosis, soreness and weakness of waist and knees, extremity numbness, metrorrhagia and metrostaxis leukorrhagia, hyperlipemia.It can seek
Hair care root makes hair follicle obtain sufficient nutrition, enables hair naturally pitch-black, and health is glossy.
Tea seed cake: also known as tea bran, tea seed cake, tea seed cake, particle are in puce, be a blob of slag of the Wild camellia seed oil fruit after extracting oil,
Except containing oil content in tea seed cake, moisture content, protamine, other than smart fiber, also containing the Tea Saponin of 12-17%, it is a kind of excellent non-
Ion natural surfactant has hair washing, hair care, black hair and anti-dandruff, Anti-hair loss and other effects.
Cacumen biotae: it is bitter, puckery, it trembles with fear.Return lung, liver, the spleen channel.Cooling blood and hemostasis, preventing phlegm from forming and stopping coughing, growing and blacking hair.For spitting blood,
Bleeding from five sense organs or subcutaneous tissue, hemoptysis, hematochezia, metrostaxis, cough with lung heat, blood-head alopecia, poliosis.
Lavender: being referred to as " King of Herbs ", the pure and fresh gracefulness of fragrance, and property is mild.With it is calm, releive, calm the nerves, urge
Dormancy effect.Can healing of wound, promote blood circulation, eliminate scar, oil-control, nourish healthy hair etc..
Gleditsia sinensis: detumescence and poison retention, apocenosis, desinsection.For ulcer from the beginning of or purulenceization do not burst;Castor is controlled outside.In can entering
Medicine, mostly in treatment acne, sty, when movable blood soft hard dissipating bind, is used.Gleditsia sinensis contains saponin component, is that one is ideal days
Right efficient surfactant, blistering, decontamination, emulsification, and hard water more resistance to than real soap, without alkalinity, to hair skin without
Stimulation and damage.
The beneficial effects of the present invention are:
1, the present invention washes shield composition using pure plant, any chemical surfactant is not added, using natural
Plant surface activating agent: tea seed cake, gleditsia sinensis, the fruit of summer cypress, deoiling, submissive gloss significantly reduce washing product to skin
Stimulation.
2, natural plants of the invention wash shield composition not silicate-containing oil: usual " silicone oil " is added to keep hair smooth
Add, but the disadvantage is that its chemical modification, when hair washing, can all adhere on residual scalp except not falling, be easy so that hair it is thick and heavy and
Gradually lose elasticity, pore is blocked and can not breathe, cause scalp hair follicles to block and occur it is swollen itch, alopecia the problems such as.It adopts
It can prevent the above problem with this natural plant formula.
3, the present invention does not add natural flavor, using thyme, folium artemisiae argyi, lavender these types fragment plant, selection
Natural perfume material not only completely avoids natural flavor disturbance endocrine and makes the pair of semen amount and sperm quantity reduction
Effect, and other effective components in these types of fragment plant also bring unique effect to product, it is manufactured to wash shield
The pure and fresh gracefulness of product fragrance, property is mild, also have promote blood circulation, tranquilizing and allaying excitement, eliminate dandruff, inhibition shave one's head,
The effects of nourishing hair.
4, pure plant of the invention washes the test of shield composition transdermal stimulation, hypersensitive test confirms, to intact skin
With damaged skin without pessimal stimulation, no sensitization reaction;Skin sensibiligen test and long term toxicity test are the results show that long
Phase uses safe and non-toxic.It is confirmed through experiment in vitro and human experimentation, natural plants of the invention, which wash shield composition, has antibacterial work
With, can infringement of the anti-pathogen to human body, health-preserving and disease-preventing adjusts the microecological balance of skin, the blood of skin promoted to follow
Ring, activating cell.Effectively reduce alopecia, profit is sent out anti-dandruff, makes that hair is submissive, glossy black and high resilience.
5, moderate foam, cleaning appropriateness prevent excessively to clean injury to scalp and skin, effective protection sebum film and
Scalp enhances the defence capability of skin itself.Natural plant formula of the invention is tested through foam, complies fully with national standard,
Not only it can guarantee effective cleaning to scalp and skin, but also can allow people while cleaning, and enjoyed hair care, anti-dandruff, taste
It supports, the health enjoyment of conditioning skin, U.S.A is wherein.
6, the present invention regains China's Traditional Chinese medicine health-preserving marrow in 5000, returns herbaceous plant activity health hair care, activation carefully
Born of the same parents, the road for nourishing skin, the safety for people wash shield, prevent injury, maintaining good health by scientific methods opens a road Tiao Xin.
Specific embodiment
To keep the purpose of the present invention, feature, advantage more obvious and understandable, below in the embodiment of the present invention
Technical solution be clearly and completely described, it is clear that the embodiments described below be only the present invention a part implement
Example, and not all embodiments.Based on the embodiments of the present invention, those skilled in the art's every other implementation obtained
Example, shall fall within the protection scope of the present invention.
Embodiment 1
10 parts of thyme, 6 parts of folium artemisiae argyi, 6 parts of lavender additions, 5 times of amount water are taken first, with extraction by steam distillation fragrance
Oil, once to get volatile oil, sealing is spare for rectifying again for gained aromatic oil.In the dregs of a decoction after mentioning oil put into 6 parts of frutus cnidii,
5 parts of the fruit of summer cypress, 10 parts of the fleece-flower root, 15 parts of tea seed cake, 5 parts of cacumen biotae, 5 parts of gleditsia sinensis be separately added into 6 times, 4 times, the heating of 3 times of amount water
It extracts three times, extraction time is respectively 2hr, 1.5hr, 1hr, is concentrated under reduced pressure, and up to extract powder after spray drying, sealing is standby
With.
Embodiment 2
15 parts of thyme, 10 parts of folium artemisiae argyi, 10 parts of lavender additions, 5 times of amount water are taken first, with extraction by steam distillation virtue
Sesame oil, once to get volatile oil, sealing is spare for rectifying again for gained aromatic oil.Frutus cnidii 10 is put into the dregs of a decoction after mentioning oil
Part, 8 parts of the fruit of summer cypress, 15 parts of the fleece-flower root, 20 parts of tea seed cake, 8 parts of cacumen biotae, 10 parts of gleditsia sinensis be separately added into 6 times, 4 times, 3 times of amount water
Three times, extraction time is respectively 2hr, 1.5hr, 1hr to heating extraction, is concentrated under reduced pressure, up to extract powder after spray drying, seals,
It is spare.
One, foam is tested
1, experimental method
Super thermostat is preheating to (40 ± 1) DEG C, makes Roche foam meter constant temperature in (40 ± 1) DEG C.It is (real to weigh sample
Apply the extract powder of the preparation of case 1) 2.5g, 1500mg/kg hard water 100mL is added, adds distilled water 900mL, is heated to (40
±1)℃.Stirring makes sample uniform dissolution, quantifies funnel with 200mL and draws part test solution, rinses along foam meter tube wall.
Then it takes test solution to be put into foam meter bottom alignment master scale to 50mL, then quantifies funnel with 200mL and draw test solution, fixed leakage
Bucket center, puts down test solution, writes down foam height immediately.As a result retain whole digit.
2, experimental result
Through detecting, foam height 63mm meets standard GB/T/T 29679-2013 requirement.Examination table
Bright, this plant component is not added with any chemical surfactant, and foaming power can also comply fully with national standard.
Note: national standard foam height are as follows: transparent type >=100mm, nontransparent type >=50mm, juvenile product >=40mm.This plant
Formula is nontransparent type product.
Two, In vitro Bactericidal Experiments
1, experimental method
1.1 strains: staphylococcus aureus (ATCC26001), escherichia coli (ATCC44112), proteus
(ATCC49001), Pseudomonas aeruginosa (ATCC27853), beta hemolytic streptococcus (ATCC32172), red hair tinea chrysanthemum (bio-
086316) pseudomonas aeruginosa (ATCC27853), acrothesium floccosum (ATCC52066) are by Hunan Hygienic & Epidemic Prevention Station
It provides.
1.2 culture mediums: nutrient broth medium (Hangzhou microorganism reagent Co., Ltd).
1.3 paper disk methods by the extract powder of case study on implementation 1 add sterile distilled water be made into 10% solution, it is spare.The diameter is taken to be
The sterilizing filter paper piece of 0.6cm impregnates 40min in this solution, takes out spare.In the plate prepared, sterile working is put
Drug sensitive test paper is set, each strain pastes 6, and then plate is set to the size cultivated in 37 DEG C of incubators and measure inhibition zone afterwards for 24 hours, taken
Its average value.
2, experimental result
Test result shows: plant composition of the invention is uncommon to acrothesium floccosum, staphylococcus aureus, large intestine angstrom
Bacterium, red hair tinea chrysanthemum have stronger bacteriostasis, to beta hemolytic streptococcus, pseudomonas aeruginosa, Pseudomonas aeruginosa, change
Shape bacillus also has different degrees of bacteriostasis, can effectively prevent (to be detailed in table to the infringement of human body with the above-mentioned pathogenic bacteria of resistance
1)。
The bacteriostatic test result of 1 plant prescription of table
Three, skin irritation test
1, experimental method
Healthy white rabbit 20, weight 2kg or so are taken, male and female dual-purpose is randomly divided into two big groups by weight: embodiment
The A group of 1 prescription, 50% solution, the B group of 50% extract powder solution of the prescription preparation of embodiment 2, every group 8.Other 4 use
Make distilled water control group.Before experiment for 24 hours, by side scissors at left and right sides of family rabbit back backbone and shaver by the hair of two sides
Depilation is respectively shaved off, damage skin is careful not to, depilation area is 5 × 10cm2。
Left side hair removal section is made into complete Skin Irritation Test, is divided into using area and check plot.A group uses smearing embodiment 1
50% solution 2ml of prescription prescription;Control group is coated with the distilled water 2m of equivalent, is covered with one layer of oilpaper, two layers of gauze, then is used glue
Cloth is fixed.Right side hair removal section makees damaged skin irritant test, the scratch of " # " shape is marked in hair removal section with syringe needle using preceding, to stab
Epidermis does not hurt corium, has slight oozing of blood for degree.Coating method is the same with dosage, and the other side compares.After 24 hours, use
Wet gauze washes away medical fluid.Respectively record 1h, for 24 hours, 48h and 72h observation smear position dermoreaction.And it is carried out by table 3 and table 4
Stimulus intensity is evaluated in scoring.It the results are shown in Table 2:
2, experimental result
The tested area's skin of intact skin group is showed no the stimulate the reactions such as erythema, oedema, non-stimulated to rabbit intact skin
Property.Damaged skin group also has no the stimulate the reactions such as erythema, oedema.
3, conclusion: as seen from the above table, the A group (low dose) of example 1 group side's preparation and the B group of 2 prescription of embodiment preparation
(large dosage) and distilled water group are to the average response value of intact skin and damage skin without significant difference.Illustrate the present invention as a result,
Plant formula component it is nonirritant to intact skin and damaged skin.
The average response value of 2 skin irritatin of table
3 skin wound repair standards of grading of table
4 skin irritation intensity evaluation standard of table
Four, skin anaphylactic test
1, experimental method
By albino guinea-pig 30, weight 250-300g, half male and half female is randomly divided into 3 groups, every group of male and female each 5, every
Animal sub-cage rearing.Guinea pig back two sides are cut off into hair in 24 hours before to tested material, removes the every side of hair-fields range about 3 × 3cm2。
A group: blank control group (applies distilled water);B group: positive controls (apply the ethanol solution of 2,4-dinitrochlorobenzene;C
Group: tested material group: (50% liquid of 2 prescription of embodiment preparation is applied.
It takes tested material 0.2ml to be coated in hair removal section on the left of animal, is covered with one layer of oilpaper and two layers of gauze, then with non-stimulated
Adhesive plaster closing is fixed, and continues 6 hours.The 7th day and the 14th day are tested, it is each in the same way to reuse once, amount to three times.
In last to 14 days after tested material sensitization, the solution 0.3ml of 2 prescription 50% of embodiment is applied to hair removal section on the right side of guinea pig back,
Remove tested material after 6 hours, observe at once, then observes cutaneous anaphylaxis situation again in 24,48,72 hours.Record
Each time allergic reaction score value infers its sensitization by sensitization incidence then according to the standard of table 5.Note: sensitization incidence
Calculating be: the animal number of cases (no matter degree weight) that erythema, oedema or systemic anaphylaxis will occur, divided by by
Try animal number, i.e. sensitization incidence.
2, experiment conclusion
From the above test result it is found that plant formula component of the invention is anaphylactoid using group and blank control group
Mean scores are 0, and sensitization incidence is also 0, and positive controls when observing at once after going tested material, 24 hours, 48
The allergic reaction mean scores of hour, 72 hours are 2.5,1.4,0.8, and the sensitization incidence of positive controls is 100%.Examination
Test the result shows that, plant formula component of the invention for guinea pig skin without sensitization react.
The standards of grading of 5 cutaneous anaphylaxis degree of table
6 hypersensitive evaluation criterion of table
Five, Skin Irritation Test is used for multiple times
1, experimental method:
8 rabbit are randomly divided into bis- groups of A, B, every group of male and female each 2, sub-cage rearing.A group: intact skin group;B group:
Damaged skin group.For two groups of animals in cutting off hair using preceding back backbone two sides for 24 hours, area is 5 × 10cm2, unhairing examines afterwards for 24 hours
Whether injured look into skin of unhairing, compromised skin does not do intact Skin Irritation Test.Damaged skin group is being lost hair or feathers with sterilizing syringe needle
Area's skin draws the scratch of " # " word, to stab epidermis, does not hurt corium, slight oozing of blood is degree.
Using androgynous left and right sides self-contrast, the solution 2ml of hair-fields painting 2 prescription 50% of embodiment, right side are gone in left side for test
Distilled water 2ml is applied as control to guarantee that tested material is not licked by animal with the fixed rabbit 6h of rabbit fixator, then go with warm water
Removal of residue observes and records daily erythema, oedema situation by preceding 3 requirement of table, and scores;It observes simultaneously and smears position
Whether pigmentation, blutpunkte, pachylosis or epidermatic atrophy situations such as is had, if any above situation, it is desirable that record its generation
And regression time.
After continuous use 7 days, half animal is put to death, hair-fields skin is removed and does histopathologic slide, after remaining animal is discontinued
It observes again 7 days, puts to death, also remove hair-fields skin and make histopathologic slide, it is strong to test medicine skin irritatin by preceding 6 requirement of table
Degree is evaluated, and the results are shown in Table 7.
Skin wound repair mean scores table is used for multiple times in table 7
As seen from the above table, being used for multiple times to the stimulate the reaction mean scores of rabbit intact skin and damaged skin is zero.
Meanwhile pigmentation, blutpunkte, pachylosis, epidermatic atrophy situation are found no using position in test, by preceding 7 standard of table
Evaluation, it is believed that plant formula component of the invention is used for multiple times even to rabbit intact skin and damaged skin nonirritant.Disease
Reason histological examination also confirms: it is non-stimulated to rabbit intact skin and damaged skin.
Six, skin sensibiligen is tested
1, experimental method
Japanese big rabbit 20, ear, half male and half female, weight 2kg or so is randomly divided into 5 groups: i.e.: A: control group (coating distillation
Water, 4ml//times);B: intact skin small dose group (solution of coating example 1 group side 50% 4ml//times, the same below);
C: intact skin large dosage group (solution of coating 2 prescription 50% of embodiment, 4ml//times);D: damaged skin small dose group
(solution of coating coating example 1 group side 50%, 4ml//times);E: (coating coating applies 2 groups of example to damaged skin large dosage group
The solution of side 50%, 4ml//times).Every group of male and female each 2, every animal sub-cage rearing.
Hair is cut off using preceding 24 hours each group men rabbit back backbone two sides, removing gross area is 5 × 10cm2.Unhairing 24 hours
Check whether skin of unhairing is injured due to unhairing, and compromised skin does not do intact skin toxicology test afterwards.
Damaged skin sterilizes syringe needle and hair-fields skin is being gone to mark " # " scratch, to stab epidermis, does not hurt corium, has slight
Oozing of blood is degree.
Groups of animals begins to use after unhairing 24 hours, is used continuously 3 times in 24 hours, and with nonirritant gauze,
Adhesive plaster is fixed.After tested material 24 hours, hair removal section skin is cleaned with warm water, removes residual tested material.It is tested in removing
1 after object, 24,48,72 hours to the 7th day, observe and record daily the weight of animal, skin and hair, eye and mucous membrane variation,
Breathing, central nervous system, four limbs activity etc. and other poisoning manifestations should perform an autopsy on sb. and meat in time if meeting dead animal
Eye observation, when there is naked eyes lesions visible, Ying Jinhang histopathologic examination.
2, experimental result
1 after groups of animals use, 24,48,72 hours to the 7th day, the weight (being shown in Table 8) of animal, skin and hair, eye and
Mucous membrane, breathing, central nervous system, four limbs activity etc. do not occur anomalous variation.The result shows that plant formula of the invention
For rabbit completely and damaged skin on do not cause acute toxic reaction, thus it is believed that this product use it is safe and non-toxic.
8 skin sensibiligen experimental rabbits changes of weight of table (kg, n=4,)
Remarks: using variance analysis, and comparison among groups P value is all larger than 0.05
Seven, the long term toxicity test of skin
1, experimental method:
Healthy new zealand rabbit 18,2.0 ± 0.3kg of weight, half male and half female is randomly divided into 3 groups, and every group 6, every dynamic
Object sub-cage rearing.One week progress Liver and kidney function of observation and blood routine examination, reject improper animal, can be tried before experiment
It tests.It is as follows to be grouped situation:
A: Normal group (applies distilled water, 2ml/ is only);B: intact skin group (applies the molten of 2 prescription 50% of embodiment
Liquid, 2ml/ is only);C: damaged skin group (solution of coating 2 prescription 50% of embodiment, 2ml/ is only);First 24 hours are tested by rabbit
The depilation of back backbone two sides is without damaging skin.Depilation area is 5 × 10cm2.It is checked after depilation 24 hours and removes depilation skin
Whether skin is injured due to unhairing, and compromised skin does not do intact skin toxicology test.
Side hair removal section is made into complete Skin Irritation Test, divides and uses area and check plot, uniformly smear tested material using area
2ml, check plot are coated with isometric distilled water, and with one layer of oilpaper, two layers of gauze were covered, then with immobilization with adhesive tape 6 hours.It is another
Side hair removal section makees damaged skin irritant test, is abraded using the preceding " # " shape that marked on hair removal section skin with syringe needle, diameter 2cm,
To stab epidermis, do not hurt corium, has slight oozing of blood for degree, coating method and dosage are the same.
Groups of animals begins to use after unhairing 24 hours.Daily skin coating is primary.
2, observation index
(1) overview: skin, overall health of patients, behavioral activity, fecal character, the food of animal are observed and recorded daily
Amount etc. is surveyed weight 1 time weekly.
(2) hematological indices: RBC, Hb, WBC, Pt.
(3) blood parameters: ALT, AST, BUN, T-CHO, Cr, TP, ALB, FBIL, GLU.
Pathological anatomy and histopathologic examination: using Some Animals are put to death after 4 weeks, pathological anatomy and histology are carried out
It checks.Main organs are weighed, organ coefficient is calculated.Some Animals continue observation 2 weeks after being discontinued, to determine toxic reaction
Invertibity and continuity.Remaining animal, same treatment are put to death after 2 weeks, and result is subjected to statistical procedures.
3, experimental result
During the experiment, each normal using group animal activity, appetite is normal, hair luster, skin, stool and urine with just
Normal control group is relatively no different paradoxical reaction.Weight increases, and blood picture, the heart, Liver and kidney function belong to normal range (NR).
Test result shows: it is nontoxic to the growth of rabbit, weight, blood picture, the heart, Liver and kidney function that the present invention implements prescription
Property reaction, it is each using group rabbit compared with the control group, or each using a group comparison among groups, difference is statistically without conspicuousness
Meaning (P > 0.05), histopathologic examination do not find test sample to the heart of experimental rabbit, liver, spleen, lung, kidney, adrenal gland, ovum
Nest, uterus, testis, epididymis, prostate, penis, skin are acted on without any toxic damages.
4, experiment conclusion
As shown in table 9, the prescription that the present invention is implemented be used for rabbit intact skin, damaged skin 4 weeks, withdrawal observation 2 weeks,
Find no apparent toxic reaction.Thus prove that the formula is safe and non-toxic.
9 skin of table long term toxicity test body weight table (kg, n=6,)
(variance analysis is used, 0.05) comparison among groups P value is all larger than
The human experimentation that profit sends out effect anti-dandruff
The extract powder 10% of the prescription of Example 1, sodium benzoate 0.3%, is implemented hydroxypropyl methyl cellulose 0.5%
Volatile oil 1%, the purifying water surplus extracted in example 1.Above-mentioned raw materials mixing, stirs evenly, and profit is made and sends out plant shampoo anti-dandruff
Liquid 1.
The extract powder 10% of the prescription of Example 2, sodium benzoate 0.3%, is implemented hydroxypropyl methyl cellulose 0.5%
Volatile oil 1%, the purifying water surplus extracted in example 2.Above-mentioned raw materials mixing, stirs evenly, and profit is made and sends out plant shampoo anti-dandruff
Liquid 2.
The extract powder 15% of the prescription of Example 1, guar gum 0.4%, paraben esters ethyl ester 0.3%, in embodiment 1
The volatile oil 1% of extraction, purifying water surplus, above-mentioned raw materials are mixed, are stirred evenly, and profit is made and sends out plant shampoo 3 anti-dandruff
Number.
The extract powder 15% of the prescription of Example 2, guar gum 0.4%, paraben esters ethyl ester 0.3%, in embodiment 2
The volatile oil 1% of extraction, purifying water surplus, above-mentioned raw materials are mixed, are stirred evenly, and profit is made and sends out plant shampoo 4 anti-dandruff
Number.
Profit send out anti-dandruff plant shampoo 1, No. 2, No. 3, No. 4 respectively to 60 volunteers' continuous use one month.One
Most of stemness of volunteer, damaged hair are moistened after month, and hair quality has clear improvement, and anti-dandruff and itching-relieving is efficient
100%.Volunteer's reflection, the plant shampoo water bubble is moderate, and faint scent is pleasant, after use, is not required to hair conditioner, hair is submissive,
It is glossy black, smooth, flexible.
The result of human experimentation prompts, and No. 4 foams are more, therefore oily hair is preferable using No. 4 effects, and stemness is damaged
Hair or other hair qualitys using No. 1, No. 2, No. 3 effects it is preferable.
Above-mentioned, although specific embodiments of the present invention have been described, not to the limit of the scope of the present invention
System, those skilled in the art should understand that, based on the technical solutions of the present invention, those skilled in the art do not need
It is still within the scope of the present invention to make the creative labor the various modifications or changes that can be made.
Claims (9)
1. a kind of pure plant washes shield composition, including following component: thyme, frutus cnidii, the fruit of summer cypress, folium artemisiae argyi, the fleece-flower root,
Tea seed cake, cacumen biotae, lavender, gleditsia sinensis.
2. pure plant according to claim 1 washes shield composition, which is characterized in that the pure plant washes shield
Composition further includes green-tea extract, radix-polygoni multiflori extract.
3. pure plant according to claim 2 washes shield composition, which is characterized in that the pure plant washes shield
Composition further includes Ginger P.E.
4. pure plant according to claim 1 washes shield composition, which is characterized in that the pure plant washes shield group
Close object, the weight proportion of each component is as follows: 10-15 parts of thyme, 6-10 parts of frutus cnidii, 5-8 parts of the fruit of summer cypress, 6-10 parts of folium artemisiae argyi,
10-15 parts of the fleece-flower root, 15-20 parts of tea seed cake, 5-8 parts of cacumen biotae, 6-10 parts of lavender, 5-10 parts of gleditsia sinensis.
5. pure plant according to claim 2 washes shield composition, which is characterized in that the pure plant washes shield
The weight proportion of composition, each component is as follows: 10-15 parts of thyme, 6-10 parts of frutus cnidii, 5-8 parts of the fruit of summer cypress, folium artemisiae argyi 6-10
Part, 10-15 parts of the fleece-flower root, 15-20 parts of tea seed cake, 5-8 parts of cacumen biotae, 6-10 parts of lavender, 5-10 parts of gleditsia sinensis, green-tea extract 3-
8 parts, 4-10 parts of radix-polygoni multiflori extract.
6. pure plant according to claim 3 washes shield composition, which is characterized in that the pure plant washes shield group
Close object, the weight proportion of each component is as follows: 10-15 parts of thyme, 6-10 parts of frutus cnidii, 5-8 parts of the fruit of summer cypress, 6-10 parts of folium artemisiae argyi,
10-15 parts of the fleece-flower root, 15-20 parts of tea seed cake, 5-8 parts of cacumen biotae, 6-10 parts of lavender, 5-10 parts of gleditsia sinensis, green-tea extract 3-8
Part, 4-10 parts of radix-polygoni multiflori extract, 3-6 parts of Ginger P.E.
7. a kind of pure plant described in any one of -6 according to claim 1 is washed the shield of washing that shield composition is prepared into and is produced
Product.
8. according to claim 7 wash shield product, which is characterized in that it is described wash shield product the preparation method is as follows:
Step 1: taking the thyme accordingly matched, folium artemisiae argyi and lavender that 5 times of amount distilled water are added first, use steam distillation
Aromatic oil is extracted, once to get volatile oil, sealing is spare for rectifying again for gained aromatic oil;
Step 2: Xiang Suoshu step 1 mentions in the dregs of a decoction after oil and puts into the frutus cnidii accordingly matched, the fruit of summer cypress, the fleece-flower root, tea seed cake, side
CedarLeaves and gleditsia sinensis, be then respectively adding 6 times, 4 times, 3 times of amounts distillation water heating extractings three times, extraction time be respectively 2hr,
1.5hr, 1hr are concentrated under reduced pressure, and up to extract powder after spray drying, sealing is spare;
Step 3: the aromatic oil and the extract powder being mixed, is prepared into and washes shield product.
9. according to claim 8 wash shield product, which is characterized in that the shield product of washing includes shampoo, hair conditioner, essence
Magnificent liquid, nutrition is spraying, any one in hair gel, hair film, pomade, hair jelly, bath foam and hand cleanser.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112121112A (en) * | 2020-10-25 | 2020-12-25 | 广东五指石科技有限公司 | Hair nourishing powder beneficial to grass and using method thereof |
CN113069390A (en) * | 2020-01-06 | 2021-07-06 | 广州樱奈儿化妆品有限公司 | Anti-hair-loss hair-growing lotion and preparation method thereof |
-
2018
- 2018-04-25 CN CN201810379879.3A patent/CN110393681A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113069390A (en) * | 2020-01-06 | 2021-07-06 | 广州樱奈儿化妆品有限公司 | Anti-hair-loss hair-growing lotion and preparation method thereof |
CN112121112A (en) * | 2020-10-25 | 2020-12-25 | 广东五指石科技有限公司 | Hair nourishing powder beneficial to grass and using method thereof |
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