CN115721683A - Electronic atomized liquid and preparation and use methods thereof - Google Patents
Electronic atomized liquid and preparation and use methods thereof Download PDFInfo
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- CN115721683A CN115721683A CN202110993893.4A CN202110993893A CN115721683A CN 115721683 A CN115721683 A CN 115721683A CN 202110993893 A CN202110993893 A CN 202110993893A CN 115721683 A CN115721683 A CN 115721683A
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
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- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Abstract
The invention discloses an electronic atomization liquid and a preparation method and a using method thereof, wherein the preparation method of the electronic atomization liquid comprises the step of mixing eucommia essential oil, camellia oil and/or olive oil according to components, and the using method comprises the step of atomizing the base oil serving as an electronic smoking set by adopting an electronic smoking set, or the step of mixing one or more modes of pressurization atomization, rotary disc atomization, gas atomization and ultrasonic atomization. The electronic atomized liquid prepared by the method fills the blank that the daily oral health care product is not prepared from edible materials with homology of medicine and food, is absorbed into the oral cavity by atomization, has better taste and has no stimulation to the oral cavity; the adopted raw materials are simple and are common in China, so that the cost is saved; and the preparation process is simple and convenient for industrial popularization.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to an electronic atomized liquid, a preparation method thereof and a use method of the electronic atomized liquid.
Background
The consciousness of the public on health is greatly improved, and the public pays attention to the health care of the body, especially the daily health protection and health care of respiratory tract and oral cavity. How to carry out daily conditioning on the oral cavity in a mode of homology of medicine and food and the like is also a focus of daily attention of people. Generally, health care medicines acting on the oral cavity are directly inhaled by oral administration or atomization and the like, and the atomization mode has better effect than the oral administration mode; because the medicine is directly inhaled through the oral cavity, the requirement on the taste of the health care medicine is higher. Therefore, a product which is prepared from edible materials with homology of medicine and food, has good taste and can be atomized and sucked into the oral cavity is urgently needed for daily oral health care.
The Eucommiae cortex is dried bark of Eucommia ulmoides Oliver (Eucommia ulmoides Oliv.) belonging to family Eucommiaceae, and the bark is used as Chinese medicine Eucommiae cortex according to Chinese pharmacopoeia. The chemical components of the eucommia bark comprise 6 to 10 percent of eucommia bark gum and 10 to 12 percent of root bark, and the eucommia bark is hard gum which is easy to dissolve in ethanol and water. In addition, the health-care product also contains 0.142 mg of glucoside, 0.066 mg of alkaloid, 6.5 mg of pectin, 2.9 mg of fat, 1.76 mg of resin, 0.25 mg of organic acid, ketose (2.15 mg before hydrolysis and 3.5 mg after hydrolysis), 20.7 mg of vitamin C, aldose and chlorogenic acid, and has various pharmacological effects such as antioxidation, antibiosis, antivirus, antitumor, blood fat reduction, blood sugar reduction, immunoregulation and the like. At present, eucommia ulmoides leaves are already included in a catalogue of homology of medicine and food, and the sources are easy to obtain.
In patent CN200310116634.5, an eucommia ulmoides leaf health-care cigarette and a manufacturing process thereof are disclosed, wherein, the eucommia ulmoides leaf is added with honey and CMC powder to replace tobacco leaves to prepare the cigarette; patent CN201910528954.2 discloses a health-preserving eucommia cigarette and a preparation method thereof, wherein a cigarette is prepared by adding a feed liquid prepared from wild plant essence, a licorice extract, a honeysuckle extract and ginseng essential oil into cut tobacco of eucommia leaves and then rolling the cut tobacco. The two patents are both the invention aims to achieve the purposes of meeting the habit and the hobby of consumers, avoiding the harm of harmful substances to human bodies, and simultaneously playing the health care and medical treatment roles of preventing and treating angiosclerosis and coronary heart disease, resisting aging, tumors and regulating blood fat on human bodies when the cigarettes are smoked, so that the harmful health of smoking is changed into the beneficial health of smoking. However, the two patents both take the ingredients of substances such as eucommia ulmoides and the like in a burning and sucking mode, on one hand, the shredded tobacco of the eucommia ulmoides leaves can generate carbon monoxide during burning, and the long-term inhalation has no health care effect on oral cavity and respiratory tract, but can generate some stimulation effect to increase the burden of the body; on the other hand, the effective components of the eucommia ulmoides leaves cannot be absorbed by a combustion and suction mode, and the health-care effect of the medicinal effect of the eucommia ulmoides cannot be achieved.
At present, no daily oral health product which is prepared from edible materials with homology of medicine and food, has good taste, can be atomized and sucked into the oral cavity and has good oral health effect is seen.
Disclosure of Invention
Because of the invasion of the novel coronavirus at present, people pay attention to daily health protection and health care of respiratory tract and oral cavity. The invention particularly develops medicinal and edible electronic atomized liquid which has good mouthfeel and can be atomized and sucked into the oral cavity and has a good oral health-care effect.
The invention aims to provide an electronic atomization liquid which comprises one or two mixtures of camellia oil and olive oil and eucommia essential oil. The eucommia ulmoides essential oil is preferably eucommia ulmoides leaf essential oil.
Wherein, the eucommia leaves belong to medicine and food homologous materials published in China, and have pharmacological actions in various aspects such as oxidation resistance, antibiosis, antivirus, antitumor, blood fat reduction, blood sugar reduction, immunoregulation and the like. Camellia oil, commonly known as Camellia seed oil, is pure natural high-grade edible plant oil extracted from mature seeds of common Camellia (Camellia oleifera Abel) of Camellia plants in the Camellia family, and has golden or light yellow color, pure quality, clarity, transparency, fragrant smell and pure taste. The camellia oil is rich in nutrition, contains fatty acids (93% of unsaturated fatty acids, wherein the oleic acid is 82%, and the linoleic acid is 11%), camellin, tea polyphenol, saponin, tannin, and squalene, squalene and flavonoids which are rich in antioxidants and have an anti-inflammatory effect, and has an excellent effect on resisting cancers. The camellia oil is also rich in vitamin E and trace elements such as calcium, iron, zinc and the like, and the zinc element which is known as 'flower of life' by medical scientists and nutriologists has the content 10 times of that of the soybean oil, and the variety of amino acid contained in the camellia oil is the most in all edible oil. Tea oil is collected and carried as medicinal oil in the Chinese pharmacopoeia (1995 edition), and has good effect for oral administration and external application because the tea oil is rich in various nutritional ingredients. Has effects in clearing away heat, eliminating dampness, killing parasite, removing toxic materials, resisting aging, clearing stomach, moistening intestine, resisting cancer, and resisting ultraviolet. Olive oil, which is rich in oleic acid, a monounsaturated fatty acid, vitamin a, vitamin B, vitamin D, vitamin E, vitamin K, antioxidants, etc., is considered as the most suitable oil for human nutrition in the oils and fats discovered so far; has effects in promoting blood circulation, improving digestive system function, protecting skin, improving endocrine system function, resisting cancer and radiation, resisting aging, preventing cardiovascular and cerebrovascular diseases, and resisting bacteria and inflammation.
Due to the antioxidant, antibacterial and antiviral effects of eucommia ulmoides, camellia oil and olive oil, the electronic atomized liquid disclosed by the invention has multiple effects of resisting bacteria, diminishing inflammation, refreshing and the like by introducing the eucommia ulmoides, camellia oil and olive oil into the formula disclosed by the invention. When in use, the medicine is sprayed in the form of mist and is used for being inhaled into oral cavities, respiratory tracts and lungs or directly sprayed to skins and affected parts, the using parts and the absorbed parts have obvious effects, and the medicine serving as medicine and food homologous medicines can be used for treating and/or preventing oral inflammatory diseases of human bodies by daily use such as long-term oral administration, external use and the like.
In a preferred embodiment, the camellia oil is present in an amount of 1 to 150 parts, preferably 10 to 100 parts, based on 1 part of the essential oil of eucommia ulmoides leaves.
In a preferred embodiment, the content of olive oil is 1 to 150 parts, preferably 10 to 100 parts, based on 1 part of the eucommia ulmoides oliv leaf essential oil.
In a preferred embodiment, the mixture of camellia oil and olive oil is contained in an amount of 1 to 150 parts, preferably 10 to 100 parts, based on 1 part of the eucommia ulmoides leaf essential oil.
In a preferred embodiment, the electronic atomization liquid optionally further comprises one or more mixtures of agilawood, sandalwood, blueberry, flower and fruit essential oil; preferably, the content of one or more of the mixture of the agilawood, the sandalwood, the blueberry, the flower and the fruit essential oil is 0-0.5 part based on 1 part of the eucommia ulmoides leaf essential oil.
In a preferred embodiment, the electronic atomization liquid optionally further comprises one or more mixtures of agilawood, sandalwood, blueberry, flower and fruit essences; preferably, based on 1 part of the eucommia ulmoides leaf essential oil, the content of one or more of agilawood, sandalwood, blueberries, flowers and fruit essences is 0-0.2 part.
Wherein, agilawood is named as the traditional Chinese medicine. The medicinal part is wood containing resin and prepared from Aquilaria sinensis (Lour.) of Thymelaeaceae. Distributed in Guangdong, hainan, guangxi, fujian, etc. The chemical components comprise volatile oil and resin. The volatile oil mainly comprises linalool, aquilaria acid, aquilaria aldehyde, aquilaria alcohol, dehydroaquilaria alcohol, aquilaria furan aldehyde, aquilaria furan alcohol, alpha-agarofuran, beta-agarofuran, anisic acid, etc.; the lignum Aquilariae Resinatum volatile oil infected by Aspergillus contains lignum Aquilariae Resinatum spiroterpene alcohol, lignum Aquilariae Resinatum spiroterpene aldehyde, etc. Has spasmolytic, tranquilizing, analgesic, blood pressure lowering, and antibacterial effects. The agilawood is added, so that the composition has a good effect of promoting qi circulation of respiratory tract and nasal cavity, can be used as a fragrance stabilizer in atomized oil, is unique in flavor, and enables the atomized essential oil to be long-lasting and leave fragrance on lips and teeth.
Sandalwood, blueberry, flower, fruit essential oil or essence can adjust the smell of the electronic atomized liquid, so that the electronic atomized liquid is more easily accepted by people.
In a preferred embodiment, the electronic atomized liquid optionally further comprises nicotine, and preferably, the content of nicotine is 0 to 0.2 parts based on 1 part of the eucommia ulmoides leaf essential oil.
The electronic atomization liquid is used as base oil of the electronic cigarette, when nicotine is added, the electronic atomization liquid is closer to the cigarette in taste, and can be used as an effective smoking cessation substitute on the basis that blend oil formed by mixing eucommia ulmoides essential oil, camellia oil and olive oil has the effects of refreshing and restoring consciousness and the like, and the oral disease treatment and health care effects can be achieved on the basis of meeting the requirements of smokers.
The second purpose of the invention is to provide a preparation method of the electronic atomized liquid.
In a preferred embodiment, the preparation method of the electronic atomized liquid comprises the step of pretreating eucommia ulmoides leaves, wherein the pretreated eucommia ulmoides leaves are used as raw materials and are mixed to extract eucommia ulmoides leaf essential oil by one or more methods of a distillation method, a CO2 supercritical method and an ethanol extraction method. The distillation method, the CO2 supercritical method and the ethanol extraction method can be operated according to the prior art. And finally, uniformly mixing the eucommia ulmoides leaf essential oil with one or two mixture components of camellia oil and olive oil.
In a preferred embodiment, the preparation method of the electronic atomized liquid comprises the step of pretreating eucommia ulmoides leaves, wherein the pretreated eucommia ulmoides leaves are used as raw materials and are mixed to extract eucommia ulmoides leaf essential oil by one or more methods of a distillation method, a CO2 supercritical method and an ethanol extraction method. The distillation method, the CO2 supercritical method and the ethanol extraction method can be operated according to the prior art. And finally, uniformly mixing the components including one or two mixtures of the eucommia ulmoides leaf essential oil, the camellia oil and the olive oil, and optionally one or more mixtures of sandalwood, blueberry, flower and fruit essential oil, and/or one or more mixtures of sandalwood, blueberry, flower and fruit essence.
In a preferred embodiment, the preparation method of the electronic atomized liquid comprises the step of pretreating eucommia ulmoides leaves, wherein the pretreated eucommia ulmoides leaves are used as raw materials and are mixed to extract eucommia ulmoides leaf essential oil by one or more methods of a distillation method, a CO2 supercritical method and an ethanol extraction method. The distillation method, the CO2 supercritical method and the ethanol extraction method can be operated according to the prior art. And finally, uniformly mixing the components including one or two mixtures of the eucommia ulmoides leaf essential oil, the camellia oil and the olive oil and optional nicotine.
The pretreatment of the eucommia ulmoides leaves comprises the following steps:
step 1: soaking fresh folium Eucommiae with vinegar solution, cleaning, and air drying; soaking the raw materials in vinegar for 1-10 s, wherein the concentration of the vinegar is 3-20%; preferably, the vinegar is adopted for soaking for 2-6 s, and the concentration of the vinegar is 3-15%. Because the eucommia leaves are provided with a film, the film causes the eucommia leaves directly to be bitter and spicy as tea drink and extracted essential oil, and in the airing process before the fresh eucommia leaves are processed, the film further adsorbs effective components in the eucommia leaves, so that the content of the effective components in the products of the tea drink and the extracted essential oil is reduced. After the vinegar solution is treated in a short-term soaking mode, the strength of the film can be preliminarily softened, and the adsorption capacity of the film on the active ingredients of the eucommia leaves in the airing process is resisted, so that the fragrance of the eucommia leaves is greatly increased, and the application prospect is improved.
Step 2: soaking the eucommia leaves subjected to the step 1 by using the vinegar solution again, and cleaning and dehydrating; in the step, vinegar is adopted for soaking for 30-90 min, and the concentration of the vinegar is 3-20%; preferably, the vinegar is adopted for soaking for 40min to 70min, and the concentration of the vinegar is 3 percent to 15 percent. Soaking in vinegar with the concentration of 3-20% for 30-90 min, so that the membrane covered on the eucommia leaves can be thoroughly softened and dissolved off the leaves, and is thoroughly removed in the subsequent cleaning and dehydration process; thereby solving the problems that the membrane covered on the eucommia leaves influences the taste of the tea drink and the essential oil and reduces the effective components.
The vinegar solution is used for soaking twice, the reason is that the first soaking is carried out because the eucommia leaves need to be subjected to impurity removal, but the eucommia leaves need to be cleaned and aired after the impurity removal, and the loss of effective components in the eucommia leaves due to the adsorption of the effective components on the films covered on the eucommia leaves can occur in the process; the problem of the loss of effective components of folium Eucommiae due to absorption of the effective components by film in the sun-drying process can be solved by soaking in vinegar solution for a short period. The second soaking is to thoroughly remove the film covered on the folium Eucommiae, thereby solving the problems that the film covered on the folium Eucommiae affects the bitter and spicy taste of tea and essential oil and reduces effective components.
And step 3: soaking the eucommia leaves obtained in the step 2 in salt water, and cleaning and dehydrating; in the step, saline water is adopted for soaking for 1min to 10min, and the concentration of the saline water is 5 percent to saturation; preferably, the mixture is soaked in saline for 3min to 8min, and the concentration of the saline is 10 percent to saturation. On one hand, the small molecular active ingredients of the eucommia leaves are extravasated along with the cell sap extravasation caused by the saline water, so that the essential oil can be conveniently extracted; on the other hand, the membrane covered by the eucommia leaves is further and thoroughly removed. Meanwhile, if the eucommia leaves are used as tea or eucommia leaf food, a small amount of salt is added in the preparation process, so that the taste of the eucommia tea or the eucommia leaf food can be greatly improved, and the health-care components of the eucommia leaf tea can be conveniently exuded.
The eucommia ulmoides leaf essential oil prepared by pretreating the eucommia ulmoides leaves in the invention removes bitter and spicy tastes, has aromatic and unique smell and good taste, and ensures that the finally obtained electronic atomized liquid has good taste and is easily accepted by people.
The third object of the present invention is to provide a method for using the electronically atomized liquid according to one of the objects of the present invention.
In a preferred embodiment, the electronic atomization liquid is used as base oil of an electronic smoking set, and is heated and atomized by the electronic smoking set; and/or ultrasonic atomization is carried out by adopting an electronic smoking set; preferably, the base oil of the electronic smoking set is optionally added with concentrated spray for treating certain diseases, such as spray for treating oral ulcer like watermelon frost spray, toothache spray, analgesic spray and the like for treating periodontitis, spray for treating rhinitis like throat panacea, spray for treating scaphium scaphigerum, fructus momordicae and the like, and spray for treating rhinitis like Yunnan herbal rhinitis. VC, VB, VA and other vitamins and natural plant extracts.
The electronic atomization liquid is used as base oil of the electronic smoking set, and is heated and atomized or ultrasonically atomized by the electronic smoking set, so that the atomized liquid is heated and atomized into droplets of micron-sized or nano-sized active ingredients, and the droplets directly act on respiratory tracts and oral cavities, and the effect of acting parts and absorbing parts is obvious; the combination mode of ultrasonic atomization and heating atomization can be used, and the optimized atomization effect can be achieved.
In a preferred embodiment, the electronic atomization liquid is mixed by one or more of pressure atomization, rotary disc atomization, gas atomization and ultrasonic atomization by using an atomizer. Optionally concentrated spray for treating certain diseases can be added, such as watermelon frost spray for treating oral ulcer, toothache spray, analgesic spray for treating periodontitis, pharyngolaryngitis spray, semen Scaphii Lychnophori, fructus Siraitiae Grosvenorii spray, yunnan herbal rhinitis spray, etc. VC, VB, VA and other vitamins and natural plant extracts, and achieves the purpose of treating or health care of diseases such as oral ulcer, periodontitis, gingivitis, rhinitis and the like.
Compared with the prior art, the invention has the following beneficial effects:
(1) The invention fills the blank that the daily oral health care product does not have an oral health care product which is prepared from edible materials with homology of medicine and food, is inhaled into the oral cavity through atomization, has better taste and has no stimulation to the oral cavity. When in use, the spray is sprayed out in the form of mist and is used for being inhaled into oral cavity, respiratory tract and lung or directly sprayed to skin and affected parts, the effect of the applied part and the absorbed part is obvious, the medicine has the efficacies of analgesia, sedation, antibiosis and antiphlogosis, and the like, and the medicine which is taken as medicine and food with the homology can be used for treating and/or preventing oral inflammation diseases of human bodies through daily use such as long-term internal administration, external use and the like.
(2) Solves the problem that the eucommia leaf essential oil extracted from the eucommia leaf is unfavorable to be used as a daily health-care product of homology of medicine and food in the oral cavity because of the spicy and bitter taste and smell of the eucommia leaf.
(3) The electronic atomization liquid provided by the invention is simple in raw materials, common in China and cost-saving; and the preparation process is simple and convenient for industrial popularization.
(4) The electronic atomization liquid is used as basic tobacco oil of the electronic cigarette, the taste of the electronic atomization liquid is closer to that of the cigarette after nicotine is added, and the electronic atomization liquid can be used as an effective smoking cessation substitute on the basis that the blend oil formed by mixing the eucommia essential oil, the camellia oil and the olive oil has the effects of refreshing and restoring consciousness and the like, and can play the effects of treating oral diseases and protecting health on the basis of meeting the requirements of smokers.
Detailed Description
While the present invention will be described in detail with reference to the following examples, it should be understood that the following examples are illustrative of the present invention and are not to be construed as limiting the scope of the present invention.
The raw materials used in the examples of the present invention and the comparative examples were all directly available on the market.
[ example 1 ] A method for producing a polycarbonate
(1) Soaking fresh folium Eucommiae in 3% vinegar solution for 10s, cleaning, and air drying;
(2) Soaking the eucommia leaves subjected to the step (1) for 90min by using a vinegar solution with the vinegar concentration of 3%, and cleaning and dehydrating;
(3) Soaking the eucommia ulmoides leaves obtained in the step (2) for 10min by using saline water (5 g/L of water), and cleaning and dehydrating;
(4) Mechanically squeezing the eucommia ulmoides leaves obtained in the step (3), collecting the obtained squeezed material cake and juice, then placing the squeezed material cake and juice above a sieve plate of a distillation still, adding a proper amount of water at the bottom of the distillation still, isolating the water from the eucommia ulmoides, and then distilling to obtain distillate generated by distillation for later use;
during distillation, the distillation speed is controlled to be 4% of the volume of the steamer, and simultaneously the cooling water flow is controlled, so that the temperature of condensate discharged in the first half hour of the distillate is 20-25 ℃, the temperature of condensate discharged after half hour is 50-55 ℃, and finally the weight of the distillate discharged is controlled to be 3 times of the weight of the eucommia leaves;
(5) Adding carbon powder accounting for 5% of the total weight of the distillate obtained in the step (4), applying microwave to the distillate to enable the temperature of the mixed solution to reach 90 ℃, keeping the state for 1 hour, naturally cooling, and filtering the carbon powder to obtain filtrate for later use;
(6) Performing oil-water separation on the filtrate obtained in the step (5) by adopting a distillation method to obtain an oil phase, namely the eucommia ulmoides leaf essential oil;
(7) Uniformly mixing 1g of folium cortex eucommiae essential oil, 10g of camellia oil and 0.1g of blueberry essential oil to obtain electronic atomized liquid;
(8) And (4) using the atomizer obtained in the step (7) in a pressurized atomization mode.
[ example 2 ]
(1) Soaking fresh folium Eucommiae in 20% vinegar solution for 1s, cleaning, and air drying;
(2) Soaking the eucommia leaves subjected to the step (1) for 30min by using a vinegar solution with the concentration of 20% of vinegar, and cleaning and dehydrating;
(3) Soaking the eucommia ulmoides leaves obtained in the step (2) for 1min by using saline (saturation), and cleaning and dehydrating;
(4) Mechanically squeezing the eucommia ulmoides leaves obtained in the step (3), collecting the obtained squeezed material cake and juice, then placing the squeezed material cake and juice above a sieve plate of a distillation still, adding a proper amount of water at the bottom of the distillation still, isolating the water from the eucommia ulmoides, and then distilling to obtain distillate generated by distillation for later use;
during distillation, the distillation speed is controlled to be 4% of the volume of the steamer, and simultaneously the cooling water flow is controlled, so that the temperature of condensate discharged in the first half hour of the distillate is 20-25 ℃, the temperature of condensate discharged after half hour is 50-55 ℃, and finally the weight of the distillate discharged is controlled to be 3 times of the weight of the eucommia leaves;
(5) Adding carbon powder accounting for 5% of the total weight of the distillate obtained in the step (4), applying microwave to the distillate to enable the temperature of the mixed solution to reach 90 ℃, keeping the state for 1 hour, naturally cooling, and filtering the carbon powder to obtain filtrate for later use;
(6) Performing oil-water separation on the filtrate obtained in the step (5) by adopting a distillation method to obtain an oil phase, namely the eucommia ulmoides leaf essential oil;
(7) Uniformly mixing 1g of folium cortex eucommiae essential oil, 100g of camellia oil and 0.5g of apple essential oil to obtain electronic atomized liquid;
(8) And (4) using the atomizer obtained in the step (7) in a rotary disc atomization mode.
[ example 3 ]
(1) Soaking fresh folium Eucommiae in 3% vinegar solution for 10s, cleaning, and air drying;
(2) Soaking the eucommia leaves subjected to the step (1) for 30min by using a vinegar solution with the concentration of 20% of vinegar, and cleaning and dehydrating;
(3) Soaking the eucommia ulmoides leaves obtained in the step (2) for 10min by using saline water (5 g/L of water), and cleaning and dehydrating;
(4) Mechanically squeezing the eucommia ulmoides leaves obtained in the step (3), collecting the obtained squeezed material cake and juice, then placing the squeezed material cake and juice above a sieve plate of a distillation still, adding a proper amount of water at the bottom of the distillation still, isolating the water from the eucommia ulmoides, and then distilling to obtain distillate generated by distillation for later use;
during distillation, the distillation speed is controlled to be 4% of the volume of the steamer, and simultaneously the flow rate of cooling water is controlled, so that the temperature of condensate discharged in the first half hour of the distillate is 20-25 ℃, the temperature of condensate discharged after half hour is 50-55 ℃, and finally the weight of the distillate discharged is controlled to be 3 times of that of the eucommia leaves;
(5) Adding carbon powder accounting for 5% of the total weight of the distillate obtained in the step (4), applying microwave to the distillate to enable the temperature of the mixed solution to reach 90 ℃, keeping the state for 1 hour, naturally cooling, and filtering the carbon powder to obtain filtrate for later use;
(6) Performing oil-water separation on the filtrate obtained in the step (5) by adopting a distillation method to obtain an oil phase, namely the eucommia ulmoides leaf essential oil;
(7) Uniformly mixing 1g of folium cortex eucommiae essential oil, 10g of olive oil and 0.1g of sandalwood essence to obtain electronic atomized liquid;
(8) And (4) using the atomization instrument obtained in the step (7) in a gas atomization mode.
[ example 4 ]
(1) Soaking fresh folium Eucommiae in 20% vinegar solution for 1s, cleaning, and air drying;
(2) Soaking the eucommia leaves subjected to the step (1) for 90min by using a vinegar solution with the vinegar concentration of 3%, and cleaning and dehydrating;
(3) Soaking the eucommia ulmoides leaves obtained in the step (2) for 1min by using saline (saturation), and cleaning and dehydrating;
(4) Mechanically squeezing the eucommia ulmoides leaves obtained in the step (3), collecting the obtained squeezed material cake and juice, then placing the squeezed material cake and juice above a sieve plate of a distillation still, adding a proper amount of water at the bottom of the distillation still, isolating the water from the eucommia ulmoides, and then distilling to obtain distillate generated by distillation for later use;
during distillation, the distillation speed is controlled to be 4% of the volume of the steamer, and simultaneously the flow rate of cooling water is controlled, so that the temperature of condensate discharged in the first half hour of the distillate is 20-25 ℃, the temperature of condensate discharged after half hour is 50-55 ℃, and finally the weight of the distillate discharged is controlled to be 3 times of that of the eucommia leaves;
(5) Adding carbon powder accounting for 5% of the total weight of the distillate obtained in the step (4), applying microwave to the distillate to enable the temperature of the mixed solution to reach 90 ℃, keeping the state for 1 hour, naturally cooling, and filtering out the carbon powder to obtain filtrate for later use;
(6) Performing oil-water separation on the filtrate obtained in the step (5) by adopting a distillation method to obtain an oil phase, namely the eucommia ulmoides leaf essential oil;
(7) Uniformly mixing 1g of eucommia ulmoides leaf essential oil, 100g of olive oil and 0.2g of nicotine to obtain electronic atomized liquid;
(8) And (4) taking the base oil obtained in the step (7) as the base oil of the electronic smoking set, and heating and atomizing the base oil by adopting the electronic smoking set.
[ example 5 ]
(1) Soaking fresh folium Eucommiae in 20% vinegar solution for 1s, cleaning, and air drying;
(2) Soaking the eucommia leaves subjected to the step (1) for 90min by using a vinegar solution with the vinegar concentration of 3%, and cleaning and dehydrating;
(3) Soaking the eucommia ulmoides leaves obtained in the step (2) for 1min by using saline water (saturation), and cleaning and dehydrating;
(4) Mechanically squeezing the eucommia ulmoides leaves obtained in the step (3), collecting the obtained squeezed material cake and juice, then placing the squeezed material cake and juice above a sieve plate of a distillation still, adding a proper amount of water at the bottom of the distillation still, isolating the water from the eucommia ulmoides, and then distilling to obtain distillate generated by distillation for later use;
during distillation, the distillation speed is controlled to be 4% of the volume of the steamer, and simultaneously the flow rate of cooling water is controlled, so that the temperature of condensate discharged in the first half hour of the distillate is 20-25 ℃, the temperature of condensate discharged after half hour is 50-55 ℃, and finally the weight of the distillate discharged is controlled to be 3 times of that of the eucommia leaves;
(5) Adding carbon powder accounting for 5% of the total weight of the distillate obtained in the step (4), applying microwave to the distillate to enable the temperature of the mixed solution to reach 90 ℃, keeping the state for 1 hour, naturally cooling, and filtering the carbon powder to obtain filtrate for later use;
(6) Performing oil-water separation on the filtrate obtained in the step (5) by adopting a distillation method to obtain an oil phase, namely the eucommia ulmoides leaf essential oil;
(7) Uniformly mixing 1g of folium cortex eucommiae essential oil, 50g of camellia oil, 50g of olive oil and 0.5g of agilawood essential oil to obtain electronic atomized liquid;
(8) And (4) using the atomizer obtained in the step (7) through ultrasonic atomization.
[ example 6 ] A method for producing a polycarbonate
(1) Soaking fresh folium Eucommiae in 20% vinegar solution for 1s, cleaning, and air drying;
(2) Soaking the eucommia leaves subjected to the step (1) for 90min by using a vinegar solution with the vinegar concentration of 3%, and cleaning and dehydrating;
(3) Soaking the eucommia ulmoides leaves obtained in the step (2) for 1min by using saline water (saturation), and cleaning and dehydrating;
(4) Mechanically squeezing the eucommia ulmoides leaves obtained in the step (3), collecting the obtained squeezed material cake and juice, then placing the squeezed material cake and juice above a sieve plate of a distillation still, adding a proper amount of water at the bottom of the distillation still, isolating the water from the eucommia ulmoides, and then distilling to obtain distillate generated by distillation for later use;
during distillation, the distillation speed is controlled to be 4% of the volume of the steamer, and simultaneously the flow rate of cooling water is controlled, so that the temperature of condensate discharged in the first half hour of the distillate is 20-25 ℃, the temperature of condensate discharged after half hour is 50-55 ℃, and finally the weight of the distillate discharged is controlled to be 3 times of that of the eucommia leaves;
(5) Adding carbon powder accounting for 5% of the total weight of the distillate obtained in the step (4), applying microwave to the distillate to enable the temperature of the mixed solution to reach 90 ℃, keeping the state for 1 hour, naturally cooling, and filtering the carbon powder to obtain filtrate for later use;
(6) Performing oil-water separation on the filtrate obtained in the step (5) by adopting a distillation method to obtain an oil phase, namely the eucommia ulmoides leaf essential oil;
(7) Uniformly mixing 1g of folium cortex eucommiae essential oil, 5g of camellia oil, 5g of olive oil and 0.1g of agilawood essential oil to obtain electronic atomized liquid;
(8) And (4) taking the base oil obtained in the step (7) as the base oil of the electronic smoking set, and carrying out ultrasonic atomization on the base oil by using the electronic smoking set.
[ example 7 ] A method for producing a polycarbonate
Repeating the steps (1) to (6) in the embodiment 6 to obtain the eucommia ulmoides leaf essential oil, then uniformly mixing 1g of the eucommia ulmoides leaf essential oil, 5g of camellia oil, 5g of olive oil and 0.2g of watermelon frost spray to obtain the electronic atomization liquid of the electronic smoking set, and carrying out ultrasonic atomization on the electronic smoking set to treat the dental ulcer in a targeted manner.
[ example 8 ]
Repeating the steps (1) - (6) of the example 6 to obtain the eucommia ulmoides leaf essential oil, then uniformly mixing 1g of the eucommia ulmoides leaf essential oil, 100g of camellia oil and 0.2g of toothache spray to obtain the electronic atomization liquid of the electronic smoking set, and performing ultrasonic atomization on the electronic smoking set to specifically treat periodontitis and the like.
[ example 9 ] A method for producing a polycarbonate
Repeating the steps (1) - (6) of the example 6 to obtain the eucommia ulmoides leaf essential oil, then uniformly mixing 1g of the eucommia ulmoides leaf essential oil, 100g of camellia oil and 0.2g of Yunnan herbal rhinitis spray to obtain the electronic atomization liquid of the electronic smoking set, and performing ultrasonic atomization on the electronic smoking set to specifically treat the rhinitis.
Comparative example 1
(1) Uniformly mixing 50g of camellia oil and 50g of olive oil to obtain electronic atomized liquid;
(2) And (3) heating and atomizing the base oil obtained in the step (2) as the base oil of the electronic smoking set for use.
Comparative example 2
100g of camellia oil is taken as electronic atomization liquid and base oil of an electronic smoking set, and the electronic smoking set is used for heating and atomizing.
[ COMPARATIVE EXAMPLE 3 ]
100g of olive oil is taken as electronic atomization liquid and base oil of an electronic smoking set, and the electronic smoking set is used for heating and atomizing.
[ Experimental example 1 ]
Using the electron atomized liquids obtained in examples 1 to 6 and comparative examples 1 to 3, 300 mice each weighing 18 to 22g were divided into 9 groups at random. The test substance was administered to the test subject in a closed space for receiving atomization 1 time per day, 2g of the atomized liquid was administered each time, and for 30 consecutive days, 9 groups of the electronic atomized liquids obtained in examples 1 to 6 and comparative examples 1 to 3 were atomized, respectively, and 1 group of the electronic atomized liquids was administered as a blank control with water as the atomized liquid.
The experiment was carried out according to the method for testing the immunity-enhancing function in "evaluation procedure and test method of health food science" issued by ministry of health, and the following experimental items were respectively carried out: (1) ConA-induced splenic lymphocyte transformation experiment in mice: the MTT method is used for measuring the proliferation capacity of the lymphocytes, and the proliferation capacity of the lymphocytes can indicate the magnitude of immunity. (2) DNFB-induced delayed allergy test (ear swelling method) in mice: DNFB is 2, 4-dinitrofluorobenzene and is a common sensitizer, DNFB is uniformly coated on the front side and the back side of a right ear of each group of mice, a left ear is not treated, and the larger the weight difference value of the left ear and the right ear is, the stronger the inflammatory reaction is, and the stronger the immunity of the mice is. (3) Measurement of the number of antibody-producing cells [ measurement of the number of hemolytic plaques ]: the larger the number of hemolytic plaques, the stronger the humoral immune function of the mouse. (4) determination of serum hemolysin: the larger the number of antibody pools, the stronger the humoral immunity.
Table 1:
[ Experimental example 2 ] clinical test
In order to verify the effect of daily conditioning on the respiratory tract and oral health of a human body in a medicine-food homologous manner, the inventor recruits 250 volunteers aged 20-70 years to test according to different age groups, wherein each age group (every 10 years) comprises 50 people, and half of the people are used as an experimental group to atomize the oral cavity for 1-2 times a day by using the electronic atomized liquid prepared in the embodiment 6; the other half of people served as a control group without the electronic atomized liquid; the test period is 5 months, wherein the days for which the experimental group can insist on using the electronic atomization liquid for daily atomization in each age group are shown in the following table 2:
TABLE 2 days of the experimental groups adhering to daily atomization with the use of the electronic atomization liquid at different ages
As can be seen from table 2, the electronic atomized liquid prepared in example 6 of the present invention has a taste acceptable to the experimental group, and can be used as a daily oral health product.
The number of respiratory tract and oral disease times of experimental group and control group in oral ulcer, pharyngolaryngitis, gingival disease, periodontitis, pericoronitis and the like during the experimental period is counted respectively, and the statistics according to the number of disease times of each age stage is as follows 3:
TABLE 3 statistical table of respiratory tract and oral disease incidence times of each age group
As can be seen from table 3, the electronic atomized liquid prepared in example 6 of the present invention can significantly reduce the frequency of respiratory tract and oral diseases such as oral ulcer, pharyngolaryngitis, gingival disease, periodontitis, pericoronitis, etc., and has significant efficacy for daily health care of respiratory tract and oral diseases.
Claims (10)
1. An electronic atomized liquid comprises oleum Camelliae Japonicae and/or oleum Olivarum, and Eucommiae cortex essential oil.
2. An electronically atomized liquid according to claim 1, wherein: the eucommia ulmoides essential oil is selected from eucommia ulmoides leaf essential oil, and preferably, the content of the camellia oil is 1-150 parts, preferably 10-100 parts, based on 1 part of the eucommia ulmoides leaf essential oil; and/or the content of the olive oil is 1 to 150 parts, preferably 10 to 100 parts based on 1 part of the eucommia ulmoides leaf essential oil; and/or the content of the mixture of camellia oil and olive oil is 1 to 150 parts, preferably 10 to 100 parts, based on 1 part of the eucommia ulmoides leaf essential oil.
3. An electronically atomized liquid according to claim 2, wherein: the electronic atomization liquid optionally further comprises one or more of agilawood, sandalwood, blueberries, flowers and fruit essential oil; preferably, based on 1 part of the eucommia ulmoides leaf essential oil, the content of one or more of the mixture of the agilawood, the sandalwood, the blueberry, the flower and the fruit essential oil is 0-0.5 part; and/or
The electronic atomization liquid optionally further comprises one or more of agilawood, sandalwood, blueberries, flowers and fruit essences; preferably, the content of one or more of agilawood, sandalwood, blueberry, flower and fruit essence is 0-0.2 part based on 1 part of the eucommia ulmoides leaf essential oil.
4. An electronically atomized liquid according to claim 2, wherein: the electronic atomized liquid optionally further comprises nicotine, and preferably, the content of the nicotine is 0-0.2 part based on 1 part of the eucommia ulmoides leaf essential oil.
5. The method for preparing the electronic atomization liquid of claim 2, which is characterized by comprising the following steps:
step 5.1, pretreating eucommia leaves;
step 5.2, distilling folium Eucommiae obtained in step 5.1 with CO 2 Extracting folium Eucommiae essential oil by supercritical method or ethanol extraction method;
and 5.3, uniformly mixing the eucommia ulmoides leaf essential oil with one or two mixture components of camellia oil and olive oil to obtain the tea oil.
6. A method for preparing the electronic atomization liquid of claim 3, which comprises the steps of:
step 6.1, pretreating the eucommia ulmoides leaves;
step 6.2, distilling folium Eucommiae obtained in step 6.1 with CO 2 Extracting folium Eucommiae essential oil by supercritical method or ethanol extraction method;
and 6.3, uniformly mixing the components including one or two mixtures of the eucommia ulmoides leaf essential oil, the camellia oil and the olive oil, and optionally one or more mixtures of agilawood, sandalwood, blueberries, flowers and fruit essential oil, and/or one or more mixtures of sandalwood, blueberries, flowers and fruit essence.
7. The method for preparing the electronic atomization liquid of claim 4, which is characterized by comprising the following steps:
step 7.1, pretreating eucommia leaves;
step 7.2, distilling folium Eucommiae obtained in step 7.1 with CO 2 Extracting folium Eucommiae essential oil by supercritical method or ethanol extraction method;
and 7.3, uniformly mixing the components including one or two mixtures of the eucommia ulmoides leaf essential oil, the camellia oil and the olive oil and optional nicotine to obtain the eucommia ulmoides leaf essential oil.
8. The method for preparing an electronically atomized liquid according to any one of claims 5 to 7, wherein the step of pretreating leaves of eucommia ulmoides oliv comprises:
step 8.1: soaking fresh folium Eucommiae in vinegar solution, cleaning, air drying,
step 8.2: soaking the eucommia leaves subjected to the step 1 by using a vinegar solution again, and cleaning and dehydrating the eucommia leaves;
step 8.3: soaking the eucommia leaves obtained in the step 2 in saline water, and cleaning and dehydrating;
preferably, in the step 8.1, the vinegar is adopted for soaking for 1 to 10 seconds, the concentration of the vinegar is 3 to 20 percent, preferably, the vinegar is adopted for soaking for 2 to 6 seconds, and the concentration of the vinegar is 3 to 15 percent; and/or, in the step 8.2, soaking for 30-90 min by using vinegar, wherein the concentration of the vinegar is 3-20%, preferably, soaking for 40-70 min by using vinegar, and the concentration of the vinegar is 3-15%; and/or, in the step 8.3, soaking for 1min to 10min by adopting brine, wherein the brine concentration is 5g/L water to saturation, preferably, soaking for 3min to 8min by adopting brine, and the brine concentration is 10g/L water to saturation.
9. Use of an electronically atomized liquid according to one of claims 2 to 4, wherein: as the base oil of the electronic smoking set, the electronic smoking set is adopted for heating and atomizing; and/or ultrasonic atomization is carried out by adopting an electronic smoking set; preferably, the base oil of the electronic smoking set is optionally added with a spray for treating oral diseases and/or a spray for treating rhinitis.
10. Use of an electronically atomized liquid according to one of the claims 2 to 4, characterized in that: one or more modes of pressurization atomization, rotary disc atomization, gas atomization and ultrasonic atomization are adopted for mixed use.
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| CN115725368A (en) * | 2021-08-27 | 2023-03-03 | 杨美琳 | Preparation method of folium cortex eucommiae essential oil, folium cortex eucommiae essential oil and application |
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| CN104403798A (en) * | 2014-11-22 | 2015-03-11 | 河南恒瑞源实业有限公司 | Preparation method of eucommia ulmoides essential oil blend |
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