CN103750538B - A kind of throat-clearing throat-moistening type tobacco oral spray agent and preparation method thereof - Google Patents
A kind of throat-clearing throat-moistening type tobacco oral spray agent and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a kind of throat-clearing throat-moistening type tobacco oral spray agent, comprises following material, counts by mass fraction: 5-30% tobacco extract; 0.14-4.2% Chinese herbal medicine extract; 1-10% flavouring essence for tobacco; All the other are auxiliary material; Wherein, described Chinese medical extract is the extract of Radix Glycyrrhizae, the sterculia seed, balloonflower root, honeysuckle, mother chrysanthemum, the Radix Astragali and cloves; The satisfaction that this spray can provide user to be equal to suck traditional cigarette also has second effect of throat-clearing throat-moistening.The invention also discloses a kind of preparation method of throat-clearing throat-moistening type tobacco oral spray agent.
Description
Technical field
The present invention relates to Field of Tobacco, relate to a kind of throat-clearing throat-moistening type tobacco oral spray agent and preparation method thereof particularly.
Background technology
Gas phase aerosol mutually two-part with grain can be produced after the traditional cigarette burning of circulating in the market.Gas phase portion accounts for 92% of whole flue gas mass, and grain mutually part accounts for 8%.Some compositions in this two parts aerosol pollute the environment, and in addition, the stub after smoking also exists the possibility of initiation fire.
Along with the step of international Tobacco Control campaign is more accelerated, national governments are especially further strict to the restriction of public place smoking to smoking, and define social consensus gradually.Under increasingly strict Tobacco Control environment, Partial Tobacco consumer may select new non-traditional tobacco product, and this variation tendency is day by day clear.According to statistics display in 2011, while worldwide cigarette volume of production and marketing declines to some extent, other types tobacco product presented quick growth trend.It is estimated, within 2011, the world's non-traditional tobacco product market sale total value is about 60,000,000,000 dollars, and wherein smoke-free tobacco product is about 16,000,000,000 dollars, becomes one the rising forces on World tobacco market.Therefore, research and develop Novel smokeless gas tobacco further and seem particularly necessary.
Smoking, the bad life habits such as to drink, and be often exposed in antihygienic air ambient people can be made easily to suffer from the common sympton such as acute and chronic pharyngitis and throat discomfort, often use antiphlogistic and Chinese patent drugs for treatment clinically, also need to take certain prevention and hygienic measures simultaneously.Traditional Chinese medicine is the treasure of the Chinese nation, plays very important effect in health-care body-nourishing, control and prevention of disease.
Summary of the invention
First technical problem that the present invention will solve is to provide a kind of throat-clearing throat-moistening type tobacco oral spray agent, comprises following material, counts by mass fraction: 5-30% tobacco extract; 0.14-4.2% Chinese herbal medicine extract; 1-10% flavouring essence for tobacco; All the other are auxiliary material; Wherein, described Chinese medical extract is the extract of Radix Glycyrrhizae, the sterculia seed, balloonflower root, honeysuckle, mother chrysanthemum, the Radix Astragali and cloves; The satisfaction that this spray can provide user to be equal to suck traditional cigarette also has second effect of throat-clearing throat-moistening.
Second technical problem that the present invention will solve is to provide a kind of preparation method of throat-clearing throat-moistening type tobacco oral spray agent.
The present invention adopts following technical proposals:
A kind of throat-clearing throat-moistening type tobacco oral spray agent, comprises following material, counts by mass fraction: 5-30% tobacco extract; 0.14-4.2% Chinese herbal medicine extract; 1-10% flavouring essence for tobacco; All the other are auxiliary material; Wherein, described Chinese medical extract is the extract of Radix Glycyrrhizae, the sterculia seed, balloonflower root, honeysuckle, mother chrysanthemum, the Radix Astragali and cloves.
Preferably, described Chinese herbal medicine extract is: 0.02-0.6% licorice, 0.02-0.6% Scaphium scaphigerum extract, 0.02-0.6% Radix Platycodonis extract, 0.02-0.6% Honegsukle flower P.E, 0.02-0.6% Flos Chrysanthemi Indici extract, 0.02-0.6% Astragalus Root P.E and 0.02-0.6% Flos Caryophylli extract.
Preferably, the pH value of described tobacco oral spray agent is 7 ~ 9; More preferably, the pH value of described tobacco oral spray agent is 9.Nicotine is one of main active in tobacco extract, and nicotine enters human circulation from buccal absorption and depends on saliva, the pH of blood plasma and the acid-base balance of nicotine.The acid-base balance of nicotine is about pH at 37 DEG C is 7.8.Suppose that the pH of saliva is 6.8, then only the nicotine of about 10% will be uncharged alkali form.Therefore, in order to promote that nicotine absorbs with free alkali form (it is the form mainly through mucosa absorption), the pH of saliva must be increased.When pH is 9.0, the nicotine more than 90% will be the free alkali form easily absorbed.
Described tobacco extract is the tobacco effective active composition extracted from tobacco leaf, refer to contain in tobacco based on the tobacco flavor material of alcohol, aldehyde, ketone, ester, hydro carbons, heterocyclic (phenmethylol, phytol, west primary three enediols, 3-methyl-2-butene aldehyde, benzaldehyde, solanone, Megastigmatrienone, dihydroactinidiolide, methyl hexadecanoate, ethyl palmitate, neophytadiene, pyridine etc.) and other bioactivator, as alkaloid, Salanesol, protein, amino acid and carbohydrate etc.
Preferably, described tobacco extract is one or more mixtures in flue-cured tobacco extract, air-curing of tobacco leaves extract, solarization tobacco extract; Described air-curing of tobacco leaves is burley tobaccos, Maryland, wrapper cigarette; Described suncured tabacco is Turkish tobaccos, Dark sun-cured, Sun cured tobacco, Nicotiniana rustica; In tobacco leaf, the content of nicotine is 2.2 ~ 2.3%.
Preferably, described tobacco extract is obtained by following steps: the 1) preparation of tobacco extract: by composite raw material, ensure that in raw tobacco, nicotine content is 2.2 ~ 2.3%, accurately take tobacco leaf powder sample, add 75-80% alcohol reflux to extract, solid-to-liquid ratio is 1:10 ~ 15, filters and get its filtrate after refluxing extraction 1 ~ 2h, at 55 ~ 65 DEG C, water-bath concentrated filtrate, obtains tobacco extract; 2) by countercurrent chromatography instrument setting different solvents system, tobacco extract is separated; 3) cut appearance time is determined; 4) Fractional Collections effective active composition, obtains tobacco extract.
High-speed counter-current chromatograph is the instrument of separation and acquisition that can be used for alkaloid compound in tobacco, flavone compound, terpenoid, organic acid compound, lignin and coumarin kind compound, quinones.
Active component in Chinese herbal medicine extract, for Radix Glycyrrhizae, the topmost active component of Radix Glycyrrhizae is exactly glycyrrhizic acid, glycyrrhizic acid is also known as glycyrrhizin, be a kind of tetraterpene derivatives, being the glucosulfone aldehyde glycosides of enoxolone, is the sweet taste composition of Radix Glycyrrhizae, be present in glycyrrhiza genus, there is anti-inflammatory, antiviral, the effect such as protecting liver and detoxication and enhancing immunologic function.
Described Chinese herbal medicine extract directly buys acquisition by market, also can extract voluntarily.When extracting voluntarily, can get indescribably by each Chinese medicine, finally mix, also once can extract the mixture of each Chinese medicine.
The equal integration of drinking and medicinal herbs of the Chinese herbal medicine related in the present invention.
Preferably, described Chinese herbal medicine extract extracts according to following steps:
Each Chinese medicine material is mixed, flood in 70 DEG C ~ 75 DEG C pure water, solid-to-liquid ratio is 1:10 ~ 15, and ultrasonic extraction is filtered after extracting 1 ~ 3h and got its filtrate, the water that filter residue adds 7 ~ 9 multiple doses again continues ultrasonic extraction 1 ~ 3h and filters and get its filtrate, merges twice filtrate; Stop concentrated when filtrate being added in Rotary Evaporators be concentrated into filtrate volume 1/3 ~ 2/3, cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.
Described Chinese herbal medicine is selected drying, free from insect pests, without Chinese herbal medicine that is mildew and rot, free from extraneous odour, is extracted after pulverizer is pulverized.
Those skilled in the art can select the flavouring essence for tobacco be applicable to as required.Specifically, first by head space distillation-GC/MS qualitative and quantitative analysis carried out to the fragrance matter of dissimilar tobacco or collect flue-cured tobacco total particulate matter in mainstream smoke with cambridge filter, GC/MS is adopted to carry out qualitative and quantitative analysis to the fragrance matter of main flume, and then tentatively draft the kind of the flavouring essence for tobacco with tobacco note, the adding proportion of adjustment different material, debate perfume (or spice) through the fragrant Shi Fanfu of cigarette, determine kind and the adding proportion of the flavouring essence for tobacco with tobacco note.Preferably; described flavouring essence for tobacco is dorinone, β-damascone, 2; 6; 6-trimethyl-2-cyclohexene-1; 4-diketone, 2-hydroxyl-3; 5; 5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, 5 methyl furfural, benzaldehyde, phenylacetaldehyde, phenmethylol, palmitic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, phenylacetic acid, dihydroactinidiolide, dimethyl succinate, indoles, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine, 2; one or more mixtures in 3,5-trimethylpyrazine.
Those skilled in the art can select the auxiliary material be applicable to as required.Preferably, described auxiliary material comprise anticorrisive agent, pH adjusting agent, sweetener, solvent.Amount ratio between various auxiliary material need not limit, and those skilled in the art can select according to actual needs.
More preferably, described anticorrisive agent is benzoic acid and sodium benzoate, propionic acid and sodium salt thereof or calcium salt, parabens and sodium salt (Sodium Methyl Hydroxybenzoate, ethyl-para-hydroxybenzoate and sodium salt thereof), sorbic acid and sylvite, potassium metabisulfite, sodium pyrosulfite, sodium sulfite, sodium hydrogensulfite or Hydros.The consumption of anticorrisive agent according to GB2760-2011≤food additives use standard >=regulation.
Described pH adjusting agent is citric acid, sorbic acid, malic acid, sodium acid carbonate or sodium hydrogen phosphate.
Described sweetener is sugar or the natural sugar of one or more synthesis, is namely suitable as any type of carbohydrate of sweetener.
Described solvent is the mixture of pure water or pure water and edible glycerol.
Add edible glycerol be in order to dissolve some not/be insoluble in the flavouring essence for tobacco of water, for example dorinone, β-damascone, 2,6,6-trimethyl-2-cyclohexene-Isosorbide-5-Nitrae-diketone, geranyl acetone, benzaldehyde, phenylacetaldehyde, palmitic acid, dihydroactinidiolide.The amount of edible glycerol meets dissolves flavouring essence for tobacco.
Spray of the present invention can adopt the various dosage strengths packaging of 20g, 50g, 100g etc.
A preparation method for throat-clearing throat-moistening type tobacco oral spray agent, comprises the following steps:
1) yellow licorice, Scaphium scaphigerum extract, Radix Platycodonis extract, Honegsukle flower P.E, Flos Chrysanthemi Indici extract, Astragalus Root P.E and Flos Caryophylli extract are dissolved, obtain mixed solution A, for subsequent use;
2) flavouring essence for tobacco is dissolved, obtain mixed solution B, for subsequent use;
3) mixed solution A and mixed solution B are merged, add tobacco extract, auxiliary material wherein, stir, regulate pH to optimum pH, then filling in spraying bottle, make finished product.
A preparation method for throat-clearing throat-moistening type tobacco oral spray agent, comprises the following steps:
1) extract of Radix Glycyrrhizae, the sterculia seed, balloonflower root, honeysuckle, mother chrysanthemum, the Radix Astragali and cloves seven taste Chinese herbal medicine is mixed, add dissolved in purified water, obtain mixed solution A, for subsequent use;
2) by flavouring essence for tobacco, add proper amount of edible glycerine and dissolve, obtain mixed solution B, for subsequent use;
3) merged by the mixed solution B of mixed solution A and exact mass, add tobacco extract, other auxiliary material wherein, pure water is quantitative, stirs, goods pH adjusting agent is adjusted to optimum pH, then filling in spraying bottle, makes finished product.
Beneficial effect of the present invention is as follows:
1, spray environmental protection of the present invention, smokeless, also has second effect of throat-clearing throat-moistening except the satisfaction of sucking traditional cigarette except user can be provided to be equal to.
2, tobacco consumer often uses this throat-clearing throat-moistening mouth sprays not for the purpose of disease therapy of the present invention to play a role in health care, and user adopts and do not have medicine association but just can enjoy throat-clearing throat-moistening effect of medicinal herb components in goods to relevant means of living; There is not yet the report of this type of throat-clearing throat-moistening type tobacco oral spray agent formula at present both at home and abroad, the present invention has broad application prospects.
3, preparation of the present invention can make user obtain being equal to the satisfaction of sucking traditional cigarette, throat-clearing throat-moistening effect of Chinese herbal medicine active component can be enjoyed again, traditional cigarette can also be avoided to burn on the harm to non-smokers and tobacco consumer self of the impact of environment and second-hand-cigarette, its research and development and Study on manufacturing technology to the scientific and technological progress of quickening tobacco, promote cigarette brand and be worth and tackle new Tobacco Control situation and have important practical significance.
4, the present invention had both been applicable to the male sex, had also been applicable to women, and user adopts and do not have medicine association but just can enjoy throat-clearing throat-moistening effect of medicinal herb components in formula to relevant means of living.
5, the flavouring essence for tobacco person's sense of smell that can provide cigarette consumption, sense of taste satisfaction is added.
6, compatibility of the present invention is reasonable, be easy to manufacture, the goods of spray-type are easy to carry, use health, spray goods of the present invention both as the interim substitute of ban on opium-smoking and the opium trade place traditional cigarette, also can become a kind of desirable novel environment friendly functional form smoke-free tobacco product in smoker's daily life.
Detailed description of the invention
In order to be illustrated more clearly in the present invention, below in conjunction with preferred embodiment, the present invention is described further.It will be appreciated by those skilled in the art that specifically described content is illustrative and nonrestrictive, should not limit the scope of the invention with this below.
Radix Glycyrrhizae property is put down, and taste is sweet, returns 12 warps, and sugariness is hundred times of sucrose, is a kind of help Chinese herbal medicine, can be clearing heat and detoxicating, and relieve sore throat wets one's whistle, moisten the lung and relieve the cough, and invigorates the spleen and benefits qi, coordinating the drug actions of a prescription.
Sterculia seed character is cold and cool, acts on lung channel, is good at clearing throat heat poison, and the clear purging the lung of pathogenic fire heat of energy, be very suitable for treating abscess of throat.
Balloonflower root, its effect for opening a surname's lung qi, apocenosis of eliminating the phlegm.Can control exogenous cough, abscess of throat, lung carbuncle pyemesis, fullness in the chest and hypochondriac pain, dysentery is suffered from abdominal pain.
Honeysuckle property sweet cold air fragrance, clear heat with drugs of sweet flavour and cold nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.It can dispelling wind-heat, and also kind removing summer-heat blood poison, can be used for various febrile disease, as the disease such as body heat, dermexanthesis, spot, hot carbuncle carbuncle, abscess of throat, and equal Be very effective.
Mother chrysanthemum is clearing heat and detoxicating, and detumescence, to staphylococcus aureus, corynebacterium diphtheriae, streptococcus, Pseudomonas aeruginosa, puncture Shigella, influenza virus, all has inhibitory action.Can be widely used in that treatment furunculosis carbuncle is swollen, abscess of throat, wind fire cute conjunctivitis, the illness such as dizzy of having a headache.
The Radix Astragali has heat-clearing and damp-drying drug, detoxicating functions.Cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, hypertension, carbuncle swell the diseases such as furuncle sore.
Embodiment 1
Preparation 20g spray goods:
(1) add 10g dissolved in purified water after Radix Glycyrrhizae, the sterculia seed, balloonflower root, honeysuckle, mother chrysanthemum, the Radix Astragali and cloves seven taste Chinese herbal medicine extract being mixed, obtain mixed solution A, for subsequent use;
(2) flavouring essence for tobacco taken in above ratio is mixed, add proper amount of edible glycerine and dissolve, obtain mixed solution B, (during use, taking exact mass as requested again) for subsequent use;
(3) merged by the mixed solution B of mixed solution A and exact mass, add tobacco extract, Nepal's ethyl ester, sucrose wherein, pure water quantitatively arrives 20g, stir, by pH adjusting agent, goods are adjusted to optimum pH, then filling in spraying bottle, make finished product.
Result of use is evaluated: organize three these spray goods of tobacco evaluation and analysis librarian use, experimental result shows, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and on average can continue 69min without smoking cigarette desire.
Embodiment 2
Preparation 50g spray goods:
(1) add 30g dissolved in purified water after Radix Glycyrrhizae, the sterculia seed, balloonflower root, honeysuckle, mother chrysanthemum, the Radix Astragali and cloves seven taste Chinese herbal medicine extract being mixed, obtain mixed solution A, for subsequent use;
(2) flavouring essence for tobacco and lemonene fragrance matter are mixed, add proper amount of edible glycerine and dissolve, obtain mixed solution B, (during use, taking exact mass as requested again) for subsequent use;
(3) merged by the mixed solution B of mixed solution A and exact mass, add tobacco extract, sorbic acid, sucrose wherein, pure water quantitatively arrives 50g, stir, by pH adjusting agent, goods are adjusted to optimum pH, then filling in spraying bottle, make finished product.
Result of use is evaluated: organize three these spray goods of tobacco evaluation and analysis librarian use, experimental result shows, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and on average can continue 60min without smoking cigarette desire.
Embodiment 3
Preparation 100g spray goods:
(1) add 65g dissolved in purified water after Radix Glycyrrhizae, the sterculia seed, balloonflower root, honeysuckle, mother chrysanthemum, the Radix Astragali and cloves seven taste Chinese herbal medicine extract being mixed, obtain mixed solution A, for subsequent use;
(2) flavouring essence for tobacco and honey peach fragrance matter are mixed, add proper amount of edible glycerine and dissolve, obtain mixed solution B, (during use, taking exact mass as requested again) for subsequent use;
(3) merged by the mixed solution B of mixed solution A and exact mass, add tobacco extract, Nepal's ethyl ester, sucrose wherein, pure water quantitatively arrives 100g, stir, by pH adjusting agent, goods are adjusted to optimum pH, then filling in spraying bottle, make finished product.
Result of use is evaluated: organize three these spray goods of tobacco evaluation and analysis librarian use, experimental result shows, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and on average can continue 52min without smoking cigarette desire.
Embodiment 4
A kind of throat-clearing throat-moistening type tobacco oral spray agent, comprises following material, counts by mass fraction: 5% tobacco extract; 0.14% Chinese herbal medicine extract; 1% flavouring essence for tobacco; All the other are auxiliary material; Wherein, described Chinese medical extract is the extract of Radix Glycyrrhizae, the sterculia seed, balloonflower root, honeysuckle, mother chrysanthemum, the Radix Astragali and cloves.
Described tobacco extract is the extract of flue-cured tobacco, obtained by following steps: the 1) preparation of tobacco extract: in flue-cured tobacco, nicotine content is 2.2 ~ 2.3%, accurately take tobacco leaf powder sample, add 75% alcohol reflux to extract, solid-to-liquid ratio is 1:10, filter after refluxing extraction 1h and get its filtrate, at 55 DEG C, water-bath concentrated filtrate, obtains tobacco extract; 2) by countercurrent chromatography instrument setting different solvents system, tobacco extract is separated; 3) cut appearance time is determined; 4) Fractional Collections effective active composition, obtains tobacco extract.
Described Chinese herbal medicine extract extracts according to following steps: mixed by each Chinese medicine material, flood in 70 DEG C of pure water, solid-to-liquid ratio is 1:10, ultrasonic extraction is filtered after extracting 1h and is got its filtrate, the ultrasonic extraction 1h of water continuation that filter residue adds 7 multiple doses again filters and gets its filtrate, merges twice filtrate; Stop concentrated when filtrate being added in Rotary Evaporators be concentrated into filtrate volume 1/3, cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.
Described flavouring essence for tobacco is dorinone, β-damascone, 2,6,6-trimethyl-2-cyclohexene-1,4-diketone, 2-hydroxyl-3, the mixture (mass ratio 1:2.5:0.5:2:2:3:1.5:2) of 5,5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, 5 methyl furfural.
Described auxiliary material comprise preservative sodium benzoate, pH adjusting agent citric acid, sweetener, solvent (mixture of water and edible glycerol).
Embodiment 5
A kind of throat-clearing throat-moistening type tobacco oral spray agent, comprises following material, counts by mass fraction: 5% tobacco extract; 0.6% licorice, 0.6% Scaphium scaphigerum extract, 0.6% Radix Platycodonis extract, 0.6% Honegsukle flower P.E, 0.6% Flos Chrysanthemi Indici extract, 0.6% Astragalus Root P.E, 0.6% Flos Caryophylli extract; 3% flavouring essence for tobacco; All the other are auxiliary material.The pH value of described tobacco oral spray agent is 7.
Described tobacco extract is the extract of burley tobaccos, Maryland and wrapper cigarette, obtained by following steps: the 1) preparation of tobacco extract: by composite raw material, ensure that nicotine content in tobacco leaf is 2.2 ~ 2.3%, accurately take tobacco leaf powder sample, add 75-80% alcohol reflux to extract, solid-to-liquid ratio is 1:10 ~ 15, filters and get its filtrate after refluxing extraction 1 ~ 2h, at 55 ~ 65 DEG C, water-bath concentrated filtrate, obtains tobacco extract; 2) by countercurrent chromatography instrument setting different solvents system, tobacco extract is separated; 3) cut appearance time is determined; 4) Fractional Collections effective active composition, obtains tobacco extract.
Described Chinese herbal medicine extract extracts according to following steps: mixed by each Chinese medicine material, flood in 75 DEG C of pure water, solid-to-liquid ratio is 1:15, ultrasonic extraction is filtered after extracting 3h and is got its filtrate, the ultrasonic extraction 3h of water continuation that filter residue adds 9 multiple doses again filters and gets its filtrate, merges twice filtrate; Stop concentrated when filtrate being added in Rotary Evaporators be concentrated into filtrate volume 2/3, cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.
Described flavouring essence for tobacco is the mixture (mass ratio 1:2.5:0.5:2:2:3:1.5:2:1) of benzaldehyde, phenylacetaldehyde, phenmethylol, palmitic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, phenylacetic acid, dihydroactinidiolide.
Described auxiliary material comprise anticorrisive agent propionic acid, pH adjusting agent malic acid, sweetener, solvent (mixture of water and edible glycerol).
Embodiment 6
A kind of throat-clearing throat-moistening type tobacco oral spray agent, comprises following material, counts by mass fraction: 30% tobacco extract; 0.6% licorice, 0.02% Scaphium scaphigerum extract, 0.02% Radix Platycodonis extract, 0.5% Honegsukle flower P.E, 0.6% Flos Chrysanthemi Indici extract, 0.02% Astragalus Root P.E, 0.02% Flos Caryophylli extract; 10% flavouring essence for tobacco; All the other are auxiliary material.The pH value of described tobacco oral spray agent is 8.
Described tobacco extract is the extract of Turkish tobaccos, Dark sun-cured, Sun cured tobacco and Nicotiniana rustica, obtained by following steps: the 1) preparation of tobacco extract: by composite raw material, ensure that nicotine content in tobacco leaf is 2.2 ~ 2.3%, accurately take tobacco leaf powder sample, add 78% alcohol reflux to extract, solid-to-liquid ratio is 1:12, filters and get its filtrate after refluxing extraction 1.5h, at 60 DEG C, water-bath concentrated filtrate, obtains tobacco extract; 2) by countercurrent chromatography instrument setting different solvents system, tobacco extract is separated; 3) cut appearance time is determined; 4) Fractional Collections effective active composition, obtains tobacco extract.
Described Chinese herbal medicine extract extracts according to following steps: mixed by each Chinese medicine material, flood in 72 DEG C of pure water, solid-to-liquid ratio is 1:12, ultrasonic extraction is filtered after extracting 2h and is got its filtrate, the ultrasonic extraction 2h of water continuation that filter residue adds 8 multiple doses again filters and gets its filtrate, merges twice filtrate; Stop concentrated when filtrate being added in Rotary Evaporators be concentrated into filtrate volume 1/2, cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.
Described flavouring essence for tobacco is the mixture (mass ratio 2.5:0.5:2:2:3:1.5:1) in dimethyl succinate, indoles, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine, 2,3,5-trimethylpyrazines.
Described auxiliary material comprise anticorrisive agent sorbic acid, pH adjusting agent sodium acid carbonate, sweetener, solvent (mixture of water and edible glycerol).
Embodiment 7
With embodiment 6, difference is: anticorrisive agent is potassium metabisulfite, pH adjusting agent is sorbic acid.
Embodiment 8
With embodiment 6, difference is: anticorrisive agent is sodium pyrosulfite, pH adjusting agent is sodium hydrogen phosphate.
Embodiment 9
With embodiment 6, difference is: anticorrisive agent is sodium hydrogensulfite.
Embodiment 10
With embodiment 6, difference is: anticorrisive agent is sodium sulfite.
Embodiment 11
With embodiment 6, difference is: anticorrisive agent is Hydros.
Embodiment 12
With embodiment 6, difference is: anticorrisive agent is p-hydroxybenzoate.
Embodiment 13
With embodiment 6, difference is: anticorrisive agent is ethyl-para-hydroxybenzoate.
Embodiment 14
With embodiment 6, difference is: anticorrisive agent is nipagin A sodium salt.
Obviously; the above embodiment of the present invention is only for example of the present invention is clearly described; and be not the restriction to embodiments of the present invention; for those of ordinary skill in the field; can also make other changes in different forms on the basis of the above description; here cannot give exhaustive to all embodiments, every belong to technical scheme of the present invention the apparent change of extending out or variation be still in the row of protection scope of the present invention.
Claims (11)
1. a throat-clearing throat-moistening type tobacco oral spray agent, is characterized in that, by mass fraction, is made up of following material: 5-30% tobacco extract; 0.14-4.2% Chinese herbal medicine extract; 1-10% flavouring essence for tobacco; All the other are auxiliary material;
Wherein, described Chinese herbal medicine extract is: 0.02-0.6% licorice, 0.02-0.6% Scaphium scaphigerum extract, 0.02-0.6% Radix Platycodonis extract, 0.02-0.6% Honegsukle flower P.E, 0.02-0.6% Flos Chrysanthemi Indici extract, 0.02-0.6% Astragalus Root P.E and 0.02-0.6% Flos Caryophylli extract.
2. throat-clearing throat-moistening type tobacco oral spray agent according to claim 1, is characterized in that, the pH value of described tobacco oral spray agent is 7 ~ 9.
3. throat-clearing throat-moistening type tobacco oral spray agent according to claim 1 and 2, is characterized in that, the pH value of described tobacco oral spray agent is 9.
4. throat-clearing throat-moistening type tobacco oral spray agent according to claim 1, is characterized in that, described tobacco extract is flue-cured tobacco extract, air-curing of tobacco leaves extract, one or more mixtures shone in tobacco extract; Described air-curing of tobacco leaves is burley tobaccos, Maryland, wrapper cigarette; Described suncured tabacco is Turkish tobaccos, Dark sun-cured, Sun cured tobacco, Nicotiniana rustica; Wherein, in tobacco leaf, the content of nicotine is 2.2 ~ 2.3%.
5. throat-clearing throat-moistening type tobacco oral spray agent according to claim 1, it is characterized in that, described tobacco extract is obtained by following steps: the 1) preparation of tobacco extract: by composite raw material, ensure that in raw tobacco, nicotine content, 2.2 ~ 2.3%, accurately takes tobacco leaf powder sample, add 75-80% alcohol reflux and extract, solid-to-liquid ratio is 1:10 ~ 15, filter after refluxing extraction 1 ~ 2h and get its filtrate, at 55 ~ 65 DEG C, water-bath concentrated filtrate, obtains tobacco extract; 2) by countercurrent chromatography instrument setting different solvents system, tobacco extract is separated; 3) cut appearance time is determined; 4) Fractional Collections effective active composition, obtains tobacco extract.
6. throat-clearing throat-moistening type tobacco oral spray agent according to claim 1, it is characterized in that, described flavouring essence for tobacco is dorinone, β-damascone, 2, 6, 6-trimethyl-2-cyclohexene-1, 4-diketone, 2-hydroxyl-3, 5, 5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, 5 methyl furfural, benzaldehyde, phenylacetaldehyde, phenmethylol, palmitic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, phenylacetic acid, dihydroactinidiolide, dimethyl succinate, indoles, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine, 2, 3, one or more mixtures in 5-trimethylpyrazine.
7. throat-clearing throat-moistening type tobacco oral spray agent according to claim 1, it is characterized in that, described auxiliary material comprise anticorrisive agent, pH adjusting agent, sweetener, solvent.
8. throat-clearing throat-moistening type tobacco oral spray agent according to claim 7, it is characterized in that, described anticorrisive agent is benzoic acid and sodium benzoate, propionic acid and sodium salt thereof or calcium salt, parabens and sodium salt thereof, sorbic acid and sylvite, potassium metabisulfite, sodium pyrosulfite, sodium sulfite, sodium hydrogensulfite or Hydros;
Described pH adjusting agent is citric acid, sorbic acid, malic acid, sodium acid carbonate or sodium hydrogen phosphate;
Described sweetener is sugar or the natural sugar of one or more synthesis;
Described solvent is the mixture of pure water or pure water and edible glycerol.
9. throat-clearing throat-moistening type tobacco oral spray agent according to claim 8, is characterized in that, described parabens and sodium salt thereof are Sodium Methyl Hydroxybenzoate, ethyl-para-hydroxybenzoate and sodium salt thereof.
10. the preparation method of the throat-clearing throat-moistening type tobacco oral spray agent as described in as arbitrary in claim 1 ~ 9, is characterized in that, comprise the following steps:
1) licorice, Scaphium scaphigerum extract, Radix Platycodonis extract, Honegsukle flower P.E, Flos Chrysanthemi Indici extract, Astragalus Root P.E and Flos Caryophylli extract are dissolved, obtain mixed solution A, for subsequent use;
2) flavouring essence for tobacco is added edible glycerol to dissolve, obtain mixed solution B, for subsequent use;
3) mixed solution A and mixed solution B are merged, add tobacco extract, auxiliary material wherein, stir, regulate pH to optimum pH, then filling in spraying bottle, make finished product.
The preparation method of 11. throat-clearing throat-moistening type tobacco oral spray agent according to claim 10, is characterized in that, comprise the following steps:
1) extract of Radix Glycyrrhizae, the sterculia seed, balloonflower root, honeysuckle, mother chrysanthemum, the Radix Astragali and cloves seven taste Chinese herbal medicine is mixed, add dissolved in purified water, obtain mixed solution A, for subsequent use;
2) flavouring essence for tobacco is added edible glycerol to dissolve, obtain mixed solution B, for subsequent use;
3) merged by the mixed solution B of mixed solution A and exact mass, add tobacco extract, other auxiliary material wherein, pure water is quantitative, stirs, goods pH adjusting agent is adjusted to optimum pH, then filling in spraying bottle, makes finished product.
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| CN104323419B (en) * | 2014-09-03 | 2016-07-13 | 湖南中烟工业有限责任公司 | The application in tobacco product of the pyridine Zn complex |
| CN105105314B (en) * | 2015-08-18 | 2017-04-19 | 云南中烟工业有限责任公司 | Powder spray agent containing tobacco components and preparation method thereof |
| CN105105315B (en) * | 2015-08-18 | 2017-07-28 | 云南中烟工业有限责任公司 | A kind of clear throat type tobacco powder spray and preparation method thereof |
| CN105361238A (en) * | 2015-12-16 | 2016-03-02 | 浙江中烟工业有限责任公司 | Electronic cigarette smoke solution containing pH conditioning agent and method for improving smoking feeling of electronic cigarette smoke solution |
| CN111838743B (en) * | 2019-04-28 | 2023-05-16 | 北京第一生物化学药业有限公司 | Snuff and preparation method thereof |
| CN113951539B (en) * | 2021-07-29 | 2022-11-25 | 云南中烟工业有限责任公司 | Oral smokeless tobacco product with multiple effects and preparation and application thereof |
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