CN103767061B - A kind of preventing decayed tooth is good for flute profile tobacco oral spray agent and preparation method thereof - Google Patents

Abstract

The present invention discloses a kind of preventing decayed tooth and is good for flute profile tobacco oral spray agent, comprises following material, counts by mass fraction: 0.1% ~ 3.0% Chinese herbal medicine extract, 5% ~ 30% tobacco extract, 1% ~ 10% flavouring essence for tobacco and other auxiliary material.Described Chinese herbal medicine extract comprises the bark of official magnolia of integration of drinking and medicinal herbs, green tea, honeysuckle, the bletilla striata and propolis.When using mouth sprays of the present invention, user can be made to obtain being equal to satisfaction when aspirating traditional cigarette, be conducive to again preventing decayed tooth in Chinese herbal medicine extract and be good for the absorption of tooth active component, traditional cigarette can also be avoided to burn on the harm to non-smokers and tobacco consumer self of the impact of environment and second-hand-cigarette.Mouth sprays formula compatibility of the present invention is reasonable, is easy to manufacture, easy to carry, use safety, both as the interim substitute of ban on opium-smoking and the opium trade place traditional cigarette, also can become a kind of desirable smoke-free tobacco product in tobacco consumer's daily life.

Description

A kind of preventing decayed tooth is good for flute profile tobacco oral spray agent and preparation method thereof

Technical field

The present invention relates to technical field of tobacco.More specifically, relate to a kind of preventing decayed tooth and be good for flute profile tobacco oral spray agent and preparation method thereof.

Background technology

Gas phase aerosol mutually two-part with grain can be produced after the traditional cigarette burning of circulating in the market.Gas phase portion accounts for 92% of whole flue gas mass, and grain mutually part accounts for 8%, and some compositions in this two parts aerosol pollute the environment, and in addition, the stub after smoking also exists the possibility of initiation fire.

Along with the step of international Tobacco Control campaign is more accelerated, the restriction of national governments to smoking smoking especially is in public places further strict, and defines social consensus gradually.Under increasingly strict Tobacco Control environment, Partial Tobacco consumer may select new non-traditional tobacco product, and this variation tendency is day by day clear.According to statistics display in 2011, while worldwide cigarette volume of production and marketing declines to some extent, other types tobacco product presents quick growth trend, it is estimated, within 2011, the world's non-traditional tobacco product market sale total value is about 60,000,000,000 dollars, wherein smoke-free tobacco product is about 16,000,000,000 dollars, becomes one the rising forces on World tobacco market.Therefore, research and develop Novel smokeless gas tobacco further and seem particularly necessary.

Dental caries disease is mankind's common disease and frequently-occurring disease, be tooth under the impact of the multiple extraneous factor based on bacterium, the disease that a kind of chronic progressive external that the enamel of tooth, dentine or cementum occur destroys.China's Incidence of caries about 35% ~ 45%, it not only destroys tissue of tooth, causes toothache, masticatory function goes down or lose, but also may invade chin bone and cause periapical periodontitis, osteomyelitis etc., affects the Health and Living quality of body.Itself and tumour, angiocardiopathy have been listed as the large keypoint control disease of the mankind three by the World Health Organization.

The etiology of dental caries theory of generally acknowledging at present is tetrad factor theory, and tetrad factor comprises bacterium, oral environment, host's (namely referring to that parasitic animal and plant comprises the parasitic organism thereon such as parasite, virus) and time.From this tetrad factor, as long as destroy any one link wherein, the just generation of energy caries prevention.Long-Time Service broad spectrum antimicrobicide and chemical synthetic drug, while removing oral cavity pathogen, also can destroy the oral cavity ecological balance, uses the Chinese medicine with antibacterial action then effectively comparatively safe.Studies in China shows, the bark of official magnolia, green tea (Tea Polyphenols), honeysuckle, the bletilla striata, propolis are the Chinese medicine preventing and treating carious tooth of Be very effective.

As can be seen here, often use the preventing decayed tooth not for the purpose of disease therapy to be good for tooth mouth sprays and can play prevention or the auxiliary health-care effect improving the malaise symptoms such as carious tooth.There is not yet the report that this type of preventing decayed tooth is good for flute profile tobacco oral spray agent formula at present both at home and abroad, therefore, need to provide a kind of preventing decayed tooth to be good for flute profile tobacco oral spray agent and preparation method thereof.

Summary of the invention

First technical problem that the present invention will solve is to provide a kind of preventing decayed tooth and is good for flute profile tobacco oral spray agent, also has second effect that preventing decayed tooth is good for tooth except this mouth sprays sucks traditional cigarette satisfaction except user can be provided to be equal to.

Second technical problem that the present invention will solve is to provide the preparation method that a kind of preventing decayed tooth is good for flute profile tobacco oral spray agent, and the method preparation technology is simple, and suitability for industrialized is produced.

For solving above-mentioned first technical problem, the present invention adopts following technical proposals:

A kind of preventing decayed tooth is good for flute profile tobacco oral spray agent, comprises following material, counts by mass fraction: 0.1% ~ 3.0% Chinese herbal medicine extract, 5% ~ 30% tobacco extract, 1% ~ 10% flavouring essence for tobacco; All the other are auxiliary material.

Preferably, described Chinese herbal medicine extract comprises 0.02 ~ 0.6% Magnolia cortex P.E, 0.02 ~ 0.6% green-tea extract, 0.02 ~ 0.6% Honegsukle flower P.E, 0.02 ~ 0.6% bletilla striata extract and 0.02 ~ 0.6% propolis extract.

Wherein, the active component in said herbal medicine extract, for the bark of official magnolia, the extract of the bark of official magnolia has strong antibacterial action to cariogenic bacteria streptococcus mutans, and its Antibacterial Constituents is defined as Magnolol and Honokiol.Both are 6.3 μ g/mL to the minimum inhibitory concentration of streptococcus mutans.The first deduction of the bark of official magnolia divides magnocurarine and Cortex Magnoliae Officinalis volatile oil saturated aqueous solution also to have certain inhibitory action to staphylococcus aureus, sarcine and hay bacillus.The preventing decayed tooth that user can enjoy medicinal herb components is good for tooth effect.

Described Chinese herbal medicine extract directly buys acquisition by market, also can extract voluntarily.When extracting voluntarily, can get indescribably by each Chinese medicine, finally mix, also once can extract the mixture of each Chinese medicine.

Preferably, described Chinese herbal medicine extract extracting method is as follows:

Each Chinese medicine material is mixed, flood in 70 DEG C ~ 75 DEG C pure water, solid-to-liquid ratio is 1:10 ~ 15, and ultrasonic extraction is filtered after extracting 1 ~ 3h and got its filtrate, the water that filter residue adds 8 ~ 9 multiple doses again continues ultrasonic extraction 1 ~ 3h and filters and get its filtrate, merges twice filtrate; Stop concentrated when filtrate being added in Rotary Evaporators be concentrated into filtrate volume 1/3 ~ 2/3, cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.

Described Chinese herbal medicine is selected drying, free from insect pests, without Chinese herbal medicine that is mildew and rot, free from extraneous odour, is extracted after pulverizer is pulverized.

Preferably, the pH value of described tobacco oral spray agent is 7 ~ 9; More preferably, the pH value of described tobacco oral spray agent is 9.Nicotine is one of main active in tobacco extract, and nicotine enters human circulation from buccal absorption and depends on saliva, the pH of blood plasma and the acid-base balance of nicotine.The acid-base balance of nicotine is about pKa=7.8 at 37 DEG C.Suppose that the pH of saliva is 6.8, then only the nicotine of about 10% will be uncharged alkali form.Therefore, in order to promote that nicotine absorbs with free alkali form (it is the form mainly through mucosa absorption), the pH of saliva must be increased.When pH is 9.0, the nicotine more than 90% will be the free alkali form easily absorbed.

Preferably, described tobacco extract to be nicotine content be 2.2 ~ 2.3% the material that extracts of tobacco leaf, comprise flue-cured tobacco extract, air-curing of tobacco leaves extract or shine one or more kinds of mixture in tobacco extract; Described air-curing of tobacco leaves comprises burley tobaccos, Maryland and wrapper cigarette; Described suncured tabacco comprises Turkish tobaccos, Dark sun-cured, Sun cured tobacco and Nicotiniana rustica.Active component in above-mentioned tobacco extract is based on the tobacco flavor material of alcohol, aldehyde, ketone, ester, hydro carbons, heterocyclic (phenmethylol, phytol, west uncle three enediols, 3-methyl-2-butene aldehyde, benzaldehyde, solanone, Megastigmatrienone, dihydroactinidiolide, methyl hexadecanoate, ethyl palmitate, neophytadiene, pyridine etc.) and other bioactivator, as alkaloid, Salanesol, protein, amino acid and carbohydrate etc.There is provided user to be equal to suck the satisfaction of traditional cigarette.

Preferably, described tobacco extract extracting method is as follows:

(1) preparation of tobacco extract: composite nicotine content is the tobacco material of 2.2 ~ 2.3%; Take above-mentioned tobacco material, add 75 ~ 80% alcohol refluxs and extract, solid-to-liquid ratio is 1:10 ~ 1:15, filters and get its filtrate after refluxing extraction 1 ~ 2h, and at 60 DEG C, water-bath concentrated filtrate, namely obtains tobacco extract; (2) by countercurrent chromatography instrument setting different solvents system, tobacco extract is separated; (3) cut appearance time is determined; (4) Fractional Collections effective active composition, obtains tobacco extract.

Preferably; described flavouring essence for tobacco comprises dorinone, β-damascone, 2; 6; 6-trimethyl-2-cyclohexene-1; 4-diketone, 2-hydroxyl-3; 5; 5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, 5 methyl furfural, benzaldehyde, phenylacetaldehyde, phenmethylol, palmitic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, phenylacetic acid, dihydroactinidiolide, dimethyl succinate, indoles, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine and 2; 3,5-trimethylpyrazine each 2 ~ 20%.First by head space distillation-GC/MS qualitative and quantitative analysis carried out to dissimilar flavouring essence for tobacco or collect flue-cured tobacco total particulate matter in mainstream smoke with cambridge filter, GC/MS is adopted to carry out qualitative and quantitative analysis to the fragrance matter of main flume, and then tentatively draft the kind of the cigarette raw material with tobacco note, the adding proportion of adjustment different material, debate perfume (or spice) through the fragrant Shi Fanfu of cigarette, determine kind and the adding proportion of the cigarette raw material with tobacco note.And itself and Chinese medical extract, tobacco extract, anticorrisive agent, sweetener, pH adjusting agent are carried out composite, obtain preventing decayed tooth and be good for tooth tobacco oral spray agent formula.User is made to enjoy sense of smell, sense of taste satisfaction.

Preferably, described auxiliary material comprise anticorrisive agent, pH adjusting agent, sweetener and solvent.

Preferably, described anticorrisive agent is benzoic acid and sodium benzoate, propionic acid, propionic acid sodium salt, propionic acid calcium salt, p-hydroxybenzoate and sodium salt, Sodium Methyl Hydroxybenzoate, any one in ethyl-para-hydroxybenzoate and sodium salt, sorbic acid and sylvite thereof, potassium metabisulfite, sodium pyrosulfite, sodium sulfite, sodium hydrogensulfite, Hydros; The consumption of anticorrisive agent is according to the regulation of GB2760-2011 " food additives use standard ".

Described pH adjusting agent is any one in citric acid, sorbic acid, malic acid, sodium acid carbonate, sodium hydrogen phosphate;

Described sweetener is sugar or the natural sugar of one or more synthesis; Namely any type of carbohydrate of sweetener is suitable as.

Described solvent is the mixture of pure water or pure water and edible glycerol.The object that the present invention adds edible glycerol be only used to dissolve some not/be insoluble in the flavouring essence for tobacco of water, its consumption can add according to those skilled in the art's experience.

For solving above-mentioned second technical problem, the present invention adopts following technical proposals:

Preventing decayed tooth is good for a preparation method for flute profile tobacco oral spray agent, comprises following preparation process:

(1) Magnolia cortex P.E, green-tea extract, Honegsukle flower P.E, bletilla striata extract, propolis extract are dissolved, obtain mixed solution A, for subsequent use;

(2) flavouring essence for tobacco is dissolved, obtain mixed solution B, for subsequent use;

(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, auxiliary material wherein, stir, regulate goods pH value by pH adjusting agent, then filling in spraying bottle, make finished product.

Preferably, following preparation process is comprised:

(1) bark of official magnolia, green tea, honeysuckle, the bletilla striata, propolis five tastes Chinese herbal medicine extract are mixed rear dissolving, obtain mixed solution A, for subsequent use;

(2) flavouring essence for tobacco is added edible glycerol to dissolve, obtain mixed solution B, for subsequent use;

(3) merged by the mixed solution B of mixed solution A and exact mass, add tobacco extract, other auxiliary material wherein, pure water is quantitative, stirs, goods pH adjusting agent is adjusted to optimum pH, then filling in spraying bottle, makes finished product.

Beneficial effect of the present invention is as follows:

(1) spray environmental protection of the present invention, smokeless, also has second effect that preventing decayed tooth is good for tooth except the satisfaction of sucking traditional cigarette except user can be provided to be equal to.

(2) the present invention had both been applicable to the male sex, had also been applicable to women, and user's employing does not have medicine association but the preventing decayed tooth that the means relevant to life just can enjoy medicinal herb components is good for tooth effect;

(3) traditional cigarette can be avoided when using of the present invention to burn on the harm to non-smokers and tobacco consumer self of the impact of environment and second-hand-cigarette;

(4) person's sense of smell that the flavouring essence for tobacco added can provide cigarette consumption, sense of taste satisfaction;

(5) compatibility of the present invention is reasonable, is easy to manufacture, and the goods of spray-type are easy to carry, uses health.In a word, both as the interim substitute of ban on opium-smoking and the opium trade place traditional cigarette, a kind of desirable novel environment friendly health smoke-free tobacco product in smoker's daily life can also can be become according to the mouth sprays goods of this formula development.

Detailed description of the invention

In order to be illustrated more clearly in the present invention, below in conjunction with preferred embodiment, the present invention is described further.It will be appreciated by those skilled in the art that specifically described content is illustrative and nonrestrictive, should not limit the scope of the invention with this below.

The bark of official magnolia: have in temperature, lower gas, eliminating dampness, dissolving phlegm function, cure mainly place food do not disappear, phlegm and retained fluid is breathed with cough, cold-damp diarrhea dysentery, toxicity is little, has rejection ability to main cariogenic bacteria oral cavity streptococcus mutans.

Green tea: the polyphenol compound extracted from green tea, as Tea Polyphenols, has anti-oxidant and function that is scavenging free radicals, has wide spectrum and potent antibacterial action and the advantage such as Drug level is low.At present, Tea Polyphenols has at home and abroad been widely used in toothpaste.

Honeysuckle: property sweet cold air fragrance, clear heat with drugs of sweet flavour and cold nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.There is clearing heat and detoxicating, that anti-inflammatory, qi-restoratives treat wind effect, can also suppress and the pathogen killing bottleneck throat, have anti-infective effect to human body.

The bletilla striata: bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.There is good astringing to arrest bleeding, detumescence and promoting granulation effect.Along with the research of modern pharmacology deepens continuously, find that the bletilla striata has obvious inhibitory action to tubercle bacillus, tumour cell etc.Clinical discovery its also have good therapeutic effect to common disease.

Propolis: mixed at the material such as the sticky discharge in the process of making honey and the natural gum in plant, resin and beeswax of nesting by worker bee, the effect of the sterilizing of propolis energy, sterilization, sterilization, antibacterial, mildew-resistant, anticorrosion, anti-inflammatory, promotion regeneration, solve the defect that antibiotic only works to single microorganism, and be free from side effects.

Embodiment 1

20g spray goods

(1) add 10g dissolved in purified water after the bark of official magnolia, green tea, honeysuckle, the bletilla striata and propolis five tastes Chinese herbal medicine extract being mixed, obtain mixed solution A, for subsequent use;

(2) flavouring essence for tobacco is mixed in proportion, add proper amount of edible glycerine and dissolve, obtain mixed solution B, (during use, taking exact mass as requested again) for subsequent use;

(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, ethyl-para-hydroxybenzoate (being commonly called as Nepal's ethyl ester), sucrose wherein, then quantitatively 20g is arrived with pure water, stir, by pH adjusting agent, goods pH value is adjusted to 7, then filling in spraying bottle, make finished product.

Result of use is evaluated: the mouth sprays goods organizing three tobacco evaluation and analysis librarian use embodiment of the present invention 1, experimental result shows, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and on average can continue 68min without smoking cigarette desire.

Embodiment 2

50g spray goods

The present embodiment preparation method is similar to embodiment 1, and raw material changes to some extent and then makes the content of active component in the tobacco of goods perfume and tobacco extract different.

(1) add 30g dissolved in purified water after the bark of official magnolia, green tea, honeysuckle, the bletilla striata and propolis five tastes Chinese herbal medicine extract being mixed, obtain mixed solution A, for subsequent use;

(2) flavouring essence for tobacco is mixed in proportion, add proper amount of edible glycerine and dissolve, obtain mixed solution B, (during use, taking exact mass as requested again) for subsequent use;

(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, sorbic acid, sucrose wherein, then quantitatively arrive 50g with pure water, stir, by pH adjusting agent, goods pH value is adjusted to 8.9, then filling in spraying bottle, make finished product.

Result of use is evaluated: the mouth sprays goods organizing three tobacco evaluation and analysis librarian use embodiment of the present invention 2, experimental result shows, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and on average can continue 60min without smoking cigarette desire.

Embodiment 3

100g spray goods

(1) add 65g dissolved in purified water after the bark of official magnolia, green tea, honeysuckle, the bletilla striata and propolis five tastes Chinese herbal medicine extract being mixed, obtain mixed solution A, for subsequent use;

(2) flavouring essence for tobacco is added edible glycerol to dissolve, obtain mixed solution B, (during use, taking exact mass as requested again) for subsequent use;

(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, Nepal's ethyl ester, sucrose wherein, then quantitatively arrive 100g with pure water, stir, by pH adjusting agent, goods pH value is adjusted to 9, then filling in spraying bottle, make finished product.

Result of use is evaluated: the mouth sprays goods organizing three tobacco evaluation and analysis librarian use embodiment of the present invention 3, experimental result shows, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and on average can continue 48min without smoking cigarette desire.

Embodiment 4

(1) 0.02% Magnolia cortex P.E, 0.02% green-tea extract, 0.02% Honegsukle flower P.E, 0.02% bletilla striata extract, 0.02% propolis extract are dissolved, obtain mixed solution A, for subsequent use;

(2) flavouring essence for tobacco of 1% is dissolved, obtain mixed solution B, for subsequent use;

(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, auxiliary material wherein, stir, regulate goods pH value by pH adjusting agent, then filling in spraying bottle, make finished product.

Embodiment 5

(1) 0.6% Magnolia cortex P.E, 0.6% green-tea extract, 0.6% Honegsukle flower P.E, 0.6% bletilla striata extract, 0.6% propolis extract are dissolved, obtain mixed solution A, for subsequent use;

(2) flavouring essence for tobacco of 10% is dissolved, obtain mixed solution B, for subsequent use;

(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, auxiliary material wherein, stir, regulate goods pH value to be 8 by pH adjusting agent, then filling in spraying bottle, make finished product.The anticorrisive agent of described auxiliary material is sodium sulfite, and sweetener is natural sugar; PH adjusting agent is citric acid.

Embodiment 6-17

Repeat embodiment 5, its difference is only, described anticorrisive agent is respectively propionic acid, propionic acid sodium salt, propionic acid calcium salt, p-hydroxybenzoate and sodium salt, Sodium Methyl Hydroxybenzoate, ethyl-para-hydroxybenzoate, P-hydroxybenzoic acid sodium salt, sorbic acid and sylvite, potassium metabisulfite, sodium pyrosulfite, sodium hydrogensulfite or Hydros.

Embodiment 18-20

Repeat embodiment 5, its difference is only, described pH adjusting agent is malic acid, sodium acid carbonate, sodium hydrogen phosphate.

Obviously; the above embodiment of the present invention is only for example of the present invention is clearly described; and be not the restriction to embodiments of the present invention; for those of ordinary skill in the field; can also make other changes in different forms on the basis of the above description; here cannot give exhaustive to all embodiments, every belong to technical scheme of the present invention the apparent change of extending out or variation be still in the row of protection scope of the present invention.

Claims (6)

1. preventing decayed tooth is good for a flute profile tobacco oral spray agent, it is characterized in that, comprises following material, counts by mass fraction: 0.1% ~ 3.0% Chinese herbal medicine extract, 5% ~ 30% tobacco extract, 1% ~ 10% flavouring essence for tobacco all the other be auxiliary material;

Described Chinese herbal medicine extract comprises 0.02 ~ 0.6% Magnolia cortex P.E, 0.02 ~ 0.6% green-tea extract, 0.02 ~ 0.6% Honegsukle flower P.E, 0.02 ~ 0.6% bletilla striata extract and 0.02 ~ 0.6% propolis extract;

Described tobacco extract to be nicotine content be 2.2 ~ 2.3% the material that extracts of tobacco leaf; One or more mixtures comprising flue-cured tobacco extract, air-curing of tobacco leaves extract or shine in tobacco extract; Described air-curing of tobacco leaves comprises burley tobaccos, Maryland and wrapper cigarette; Described suncured tabacco comprises Turkish tobaccos, Dark sun-cured, Sun cured tobacco and Nicotiniana rustica;

Described flavouring essence for tobacco comprises dorinone, β-damascone, 2; 6; 6-trimethyl-2-cyclohexene-1; 4-diketone, 2-hydroxyl-3; 5; 5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, 5 methyl furfural, benzaldehyde, phenylacetaldehyde, phenmethylol, palmitic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, phenylacetic acid, dihydroactinidiolide, dimethyl succinate, indoles, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine and 2; one or more mixtures in 3,5-trimethylpyrazine.

2. preventing decayed tooth according to claim 1 is good for flute profile tobacco oral spray agent, it is characterized in that, described tobacco oral spray agent pH value is 7 ~ 9.

3. preventing decayed tooth according to claim 1 is good for flute profile tobacco oral spray agent, it is characterized in that, described tobacco extract extracting method is as follows:

(1) preparation of tobacco extract: composite nicotine content is the tobacco material of 2.2 ~ 2.3%; Take above-mentioned tobacco material, add 75 ~ 80% alcohol refluxs and extract, solid-to-liquid ratio is 1:10 ~ 1:15, filters and get its filtrate after refluxing extraction 1 ~ 2h, and at 60 DEG C, water-bath concentrated filtrate, namely obtains tobacco extract; (2) by countercurrent chromatography instrument setting different solvents system, tobacco extract is separated; (3) cut appearance time is determined; (4) Fractional Collections effective active composition, obtains tobacco extract.

4. preventing decayed tooth according to claim 1 is good for flute profile tobacco oral spray agent, it is characterized in that, described auxiliary material comprise anticorrisive agent, sweetener, solvent and pH adjusting agent;

Described anticorrisive agent is any one in benzoic acid and sodium benzoate, propionic acid, propionic acid sodium salt, propionic acid calcium salt, p-hydroxybenzoate and sodium salt, sorbic acid and sylvite thereof, potassium metabisulfite, sodium pyrosulfite, sodium sulfite, sodium hydrogensulfite, Hydros;

Described sweetener is sugar or the natural sugar of one or more synthesis;

Described solvent is the mixture of pure water or pure water and edible glycerol;

Described pH adjusting agent is any one in citric acid, sorbic acid, malic acid, sodium acid carbonate, sodium hydrogen phosphate.

5. the preventing decayed tooth as described in as arbitrary in Claims 1 to 4 is good for the preparation method of flute profile tobacco oral spray agent, it is characterized in that, comprises following preparation process:

(1) Magnolia cortex P.E, green-tea extract, Honegsukle flower P.E, bletilla striata extract, propolis extract are dissolved, obtain mixed solution A, for subsequent use;

(2) flavouring essence for tobacco is dissolved, obtain mixed solution B, for subsequent use;

(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, auxiliary material wherein, stir, regulate goods pH value by pH adjusting agent, then filling in spraying bottle, make finished product.

6. preventing decayed tooth according to claim 5 is good for the preparation method of flute profile tobacco oral spray agent, it is characterized in that, comprises the following steps:

(1) bark of official magnolia, green tea, honeysuckle, the bletilla striata, propolis five tastes Chinese herbal medicine extract are mixed rear dissolving, obtain mixed solution A, for subsequent use;

(2) flavouring essence for tobacco is added edible glycerol to dissolve, obtain mixed solution B, for subsequent use;

(3) merged by the mixed solution B of mixed solution A and exact mass, add tobacco extract, other auxiliary material wherein, pure water is quantitative, stir, goods pH adjusting agent is adjusted to optimum pH, then filling in spraying bottle, make finished product.