CN103798953B - A kind of inrigorating qi and promoting blood circulation type tobacco oral spray agent and preparation method thereof - Google Patents
A kind of inrigorating qi and promoting blood circulation type tobacco oral spray agent and preparation method thereof Download PDFInfo
- Publication number
- CN103798953B CN103798953B CN201410027484.9A CN201410027484A CN103798953B CN 103798953 B CN103798953 B CN 103798953B CN 201410027484 A CN201410027484 A CN 201410027484A CN 103798953 B CN103798953 B CN 103798953B
- Authority
- CN
- China
- Prior art keywords
- tobacco
- extract
- acid
- inrigorating
- blood circulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a kind of inrigorating qi and promoting blood circulation type tobacco oral spray agent, comprises following material, counts by mass fraction: 0.14 ~ 4.2% Chinese herbal medicine extract; 5 ~ 30% tobacco extracts; 1 ~ 10% flavouring essence for tobacco; All the other are auxiliary material; Described Chinese herbal medicine extract comprises the Radix Astragali of integration of drinking and medicinal herbs, pseudo-ginseng, safflower, Radix Angelicae Sinensis, cultivated land, the radix paeoniae rubrathe, rhizome of chuanxiong.Also there is except this mouth sprays sucks traditional cigarette satisfaction except user can be provided to be equal to second effect of inrigorating qi and promoting blood circulation, traditional cigarette can also be avoided to burn on the harm to non-smokers and tobacco consumer self of the impact of environment and second-hand-cigarette.Mouth sprays formula compatibility of the present invention is reasonable, be easy to manufacture, the mouth sprays adopting this formula to develop is easy to carry, use safety, both as the interim substitute of ban on opium-smoking and the opium trade place traditional cigarette, a kind of desirable smoke-free tobacco product in tobacco consumer's daily life can also can be become.
Description
Technical field
The present invention relates to technical field of tobacco.More specifically, a kind of inrigorating qi and promoting blood circulation type tobacco oral spray agent and preparation method thereof is related to.
Background technology
Gas phase aerosol mutually two-part with grain can be produced after the traditional cigarette burning of circulating in the market.Gas phase portion accounts for 92% of whole flue gas mass, and grain mutually part accounts for 8%, and some compositions in this two parts aerosol pollute the environment, and in addition, the stub after smoking also exists the possibility of initiation fire.
Along with the step of international Tobacco Control campaign is more accelerated, the restriction of national governments to smoking smoking especially is in public places further strict, and defines social consensus gradually.Under increasingly strict Tobacco Control environment, Partial Tobacco consumer may select new non-traditional tobacco product, and this variation tendency is day by day clear.According to statistics display in 2011, while worldwide cigarette volume of production and marketing declines to some extent, other types tobacco product presents quick growth trend, it is estimated, within 2011, the world's non-traditional tobacco product market sale total value is about 60,000,000,000 dollars, wherein smoke-free tobacco product is 16,000,000,000 dollars, becomes one the rising forces on World tobacco market.Therefore, research and develop Novel smokeless gas tobacco product further and seem particularly necessary.
The traditional Chinese medical science is thought, qi and blood is the foundation of human life, is nutrition organs and tissues, the energy of the activity that sustains life.The deficiency of vital energy in insufficiency of vital energy and blood and traditional Chinese medicine and the deficiency of blood, may cause going down of function, cause the pathologies such as early ageing.The result of Traditional Chinese Medicine checking in several thousand shows, a kind of method that when Chinese medicine is inrigorating qi and promoting blood circulation, curative effect is the most stable, and the Chinese medicine of energy inrigorating qi and promoting blood circulation is also a lot, and it is significant that the Radix Astragali, pseudo-ginseng, safflower, Radix Angelicae Sinensis, cultivated land, the radix paeoniae rubrathe, rhizome of chuanxiong all belong to effectiveness comparison.As can be seen here, often use the inrigorating qi and promoting blood circulation type mouth sprays not for the purpose of disease therapy can play prevention or assist and improve the health-care effect that insufficiency of vital energy and blood fits symptom.There is not yet the report of this type of inrigorating qi and promoting blood circulation type tobacco oral spray agent formula at present both at home and abroad.
Therefore, need to provide a kind of inrigorating qi and promoting blood circulation type tobacco oral spray agent and preparation method thereof.
Summary of the invention
First technical problem that the present invention will solve is to provide a kind of inrigorating qi and promoting blood circulation type tobacco oral spray agent, also has second effect of inrigorating qi and promoting blood circulation except this mouth sprays sucks traditional cigarette satisfaction except user can be provided to be equal to.
Second technical problem that the present invention will solve is to provide a kind of preparation method of inrigorating qi and promoting blood circulation type tobacco oral spray agent, and the method preparation technology is simple, and suitability for industrialized is produced.
For solving above-mentioned first technical problem, the present invention adopts following technical proposals:
A kind of inrigorating qi and promoting blood circulation type tobacco oral spray agent, comprises following material, counts by mass fraction: 0.14 ~ 4.2% Chinese herbal medicine extract; 5 ~ 30% tobacco extracts; 1 ~ 10% flavouring essence for tobacco; All the other are auxiliary material.
Preferably, described Chinese herbal medicine extract comprises 0.02 ~ 0.6% Astragalus Root P.E, 0.02 ~ 0.6% Notogineng Extract, 0.02 ~ 0.6% safflower extract, 0.02 ~ 0.6% angelica extract, 0.02 ~ 0.6% cultivated land extract, 0.02 ~ 0.6% red paeonia extract and 0.02 ~ 0.6% rhizome of chuanxiong extract.
Wherein, active component in said herbal medicine extract, for the Radix Astragali, polysaccharide (the astragalus polyose I existed in the Radix Astragali, II, III, heteroglycan AH-1), triterpene saponin (astragalin I-VII, astragalin VIII, acetyl astragalin I, different astragalin I, different astragalin II), flavonoids (hair stamen flavones-7-O-β-D-Glucose glycosides, the bright xanthin of hair, calycosin, calycosin-7-O-glucoside, daucosterol), 25 seed amino acid (glutamic acid, proline, arginine, mountain arrow acid, L-canavanine, GABA), alkaloid (betaine, choline) etc. number of chemical material be exactly its active component.User can enjoy inrigorating qi and promoting blood circulation effect of medicinal herb components.
Described Chinese herbal medicine extract directly buys acquisition by market, also can extract voluntarily.When extracting voluntarily, can get indescribably by each Chinese medicine, finally mix, also once can extract the mixture of each Chinese medicine.
Preferably, described Chinese herbal medicine extract extracting method is as follows:
Each Chinese medicine material is mixed, flood in 70 DEG C ~ 75 DEG C pure water, solid-to-liquid ratio is 1:10 ~ 15, and ultrasonic extraction is filtered after extracting 1 ~ 3h and got its filtrate, the water that filter residue adds 8 ~ 9 multiple doses again continues ultrasonic extraction 1 ~ 3h and filters and get its filtrate, merges twice filtrate; Stop concentrated when filtrate being added in Rotary Evaporators be concentrated into filtrate volume 1/3 ~ 2/3, cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.
Described Chinese herbal medicine is selected drying, free from insect pests, without Chinese herbal medicine that is mildew and rot, free from extraneous odour, is extracted after pulverizer is pulverized.
Preferably, the pH value of described tobacco oral spray agent is 7 ~ 9; More preferably, the pH value of described tobacco oral spray agent is 9.Nicotine is one of main active in tobacco extract, and nicotine enters human circulation from buccal absorption and depends on saliva, the pH of blood plasma and the acid-base balance of nicotine.The acid-base balance of nicotine is about pKa=7.8 at 37 DEG C.Suppose that the pH of saliva is 6.8, then only the nicotine of about 10% will be uncharged alkali form.Therefore, in order to promote that nicotine absorbs with free alkali form (it is the form mainly through mucosa absorption), the pH of saliva must be increased.When pH is 9.0, the nicotine more than 90% will be the free alkali form easily absorbed.
Preferably, described tobacco extract to be nicotine content be 2.2 ~ 2.3% the material that extracts of tobacco leaf, comprise flue-cured tobacco extract, air-curing of tobacco leaves extract or shine one or more kinds of mixture in tobacco extract; Described air-curing of tobacco leaves comprises burley tobaccos, Maryland and wrapper cigarette; Described suncured tabacco comprises Turkish tobaccos, Dark sun-cured, Sun cured tobacco and Nicotiniana rustica.Active component in above-mentioned tobacco extract is based on the tobacco flavor material of alcohol, aldehyde, ketone, ester, hydro carbons, heterocyclic (phenmethylol, phytol, west uncle three enediols, 3-methyl-2-butene aldehyde, benzaldehyde, solanone, Megastigmatrienone, dihydroactinidiolide, methyl hexadecanoate, ethyl palmitate, neophytadiene, pyridine etc.) and other bioactivator, as alkaloid, Salanesol, protein, amino acid and carbohydrate etc.There is provided user to be equal to suck the satisfaction of traditional cigarette.
Preferably, described tobacco extract extracting method is as follows:
(1) preparation of tobacco extract: composite nicotine content is the tobacco material of 2.2 ~ 2.3%; Take above-mentioned tobacco material, add 75-80% alcohol reflux and extract, solid-to-liquid ratio is 1:10 ~ 1:15, filters and get its filtrate after refluxing extraction 1 ~ 2h, and at 60 DEG C, water-bath concentrated filtrate, namely obtains tobacco extract; (2) by countercurrent chromatography instrument setting different solvents system, tobacco extract is separated; (3) cut appearance time is determined; (4) Fractional Collections effective active composition, obtains tobacco extract.
Preferably; described flavouring essence for tobacco comprises dorinone, β-damascone, 2; 6; 6-trimethyl-2-cyclohexene-1; 4-diketone, 2-hydroxyl-3; 5; 5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, 5 methyl furfural, benzaldehyde, phenylacetaldehyde, phenmethylol, palmitic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, phenylacetic acid, dihydroactinidiolide, dimethyl succinate, indoles, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine and 2; 3,5-trimethylpyrazine each 2 ~ 20%.First by head space distillation-GC/MS qualitative and quantitative analysis carried out to dissimilar flavouring essence for tobacco or collect flue-cured tobacco total particulate matter in mainstream smoke with cambridge filter, GC/MS is adopted to carry out qualitative and quantitative analysis to the fragrance matter of main flume, and then tentatively draft the kind of the cigarette raw material with tobacco note, the adding proportion of adjustment different material, debate perfume (or spice) through the fragrant Shi Fanfu of cigarette, determine kind and the adding proportion of the cigarette raw material with tobacco note.And itself and Chinese medical extract, tobacco extract, anticorrisive agent, sweetener, pH adjusting agent are carried out composite, obtain inrigorating qi and promoting blood circulation tobacco oral spray agent formula.User is made to enjoy sense of smell, sense of taste satisfaction.
Preferably, described auxiliary material comprise anticorrisive agent, pH adjusting agent, sweetener and solvent.
Preferably, described anticorrisive agent is benzoic acid and sodium benzoate, propionic acid, propionic acid sodium salt, propionic acid calcium salt, p-hydroxybenzoate and sodium salt, Sodium Methyl Hydroxybenzoate, any one in ethyl-para-hydroxybenzoate and sodium salt, sorbic acid and sylvite thereof, potassium metabisulfite, sodium pyrosulfite, sodium sulfite, sodium hydrogensulfite, Hydros; The consumption of anticorrisive agent is according to the regulation of GB2760-2011 " food additives use standard ".
Described pH adjusting agent is any one in citric acid, sorbic acid, malic acid, sodium acid carbonate, sodium hydrogen phosphate;
Described sweetener is sugar or the natural sugar of one or more synthesis; Namely any type of carbohydrate of sweetener is suitable as.
Described solvent is the mixture of pure water or pure water and edible glycerol.The object that the present invention adds edible glycerol be only used to dissolve some not/be insoluble in the flavouring essence for tobacco of water, its consumption can add according to those skilled in the art's experience.
For solving above-mentioned second technical problem, the present invention adopts following technical proposals:
A preparation method for inrigorating qi and promoting blood circulation type tobacco oral spray agent, comprises following preparation process:
(1) Astragalus Root P.E, Notogineng Extract, safflower extract, angelica extract, cultivated land extract, red paeonia extract, rhizome of chuanxiong extract are dissolved, obtain mixed solution A, for subsequent use;
(2) flavouring essence for tobacco is dissolved, obtain mixed solution B, for subsequent use;
(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, auxiliary material wherein, stir, regulate goods pH value by pH adjusting agent, then filling in spraying bottle, make finished product.
Preferably, following preparation process is comprised:
(1) Radix Astragali, pseudo-ginseng, safflower, Radix Angelicae Sinensis, cultivated land, the radix paeoniae rubrathe, rhizome of chuanxiong seven taste Chinese herbal medicine extract are added dissolved in purified water after mixing, obtain mixed solution A, for subsequent use;
(2) flavouring essence for tobacco is mixed, add edible glycerol and dissolve, obtain mixed solution B, for subsequent use;
(3) merged by the mixed solution B of mixed solution A and exact mass, add tobacco extract, other auxiliary material wherein, pure water is quantitative, stirs, goods pH adjusting agent is adjusted to optimum pH, then filling in spraying bottle, makes finished product.
Beneficial effect of the present invention is as follows:
(1) spray environmental protection of the present invention, smokeless, also has second effect of inrigorating qi and promoting blood circulation except the satisfaction of sucking traditional cigarette except user can be provided to be equal to.
(2) the present invention had both been applicable to the male sex, had also been applicable to women, and user adopts and do not have medicine association but just can enjoy inrigorating qi and promoting blood circulation effect of medicinal herb components to relevant means of living;
(3) traditional cigarette can be avoided when using of the present invention to burn on the harm to non-smokers and tobacco consumer self of the impact of environment and second-hand-cigarette;
(4) person's sense of smell that the flavouring essence for tobacco added can provide cigarette consumption, sense of taste satisfaction;
(5) compatibility of the present invention is reasonable, is easy to manufacture, and the goods of spray-type are easy to carry, uses health.In a word, both as the interim substitute of ban on opium-smoking and the opium trade place traditional cigarette, a kind of desirable novel environment friendly health smoke-free tobacco product in smoker's daily life can also can be become according to the mouth sprays goods of this formula development.
Detailed description of the invention
In order to be illustrated more clearly in the present invention, below in conjunction with preferred embodiment, the present invention is described further.It will be appreciated by those skilled in the art that specifically described content is illustrative and nonrestrictive, should not limit the scope of the invention with this below.
The Radix Astragali: taste is sweet, warm in nature and, strongly invigorating QI and blood, have rush down naked light, beneficial healthy tendency, strong taste, go flesh heat, the function of doctor's sore of invigorating blood circulation;
Pseudo-ginseng: hemostasis, the loose stasis of blood, detumescence, analgesic therapy, hemangiectasis, to reduce blood pressure, improves microcirculation, increases CBF, prevention and therapy heart and brain tissues ischemic;
Red ginseng: warm in nature, taste is pungent, activating blood to promote menstruation, blood stasis removing analgesic;
Radix Angelicae Sinensis: taste is sweet and weigh, and bowl spares has, have benefit in row, gas is light and pungent, can enrich blood, and can invigorate blood circulation again, both can stimulate the menstrual flow, again can be active;
Cultivated land: sweet Wen Zhirun, tonifying yin benefit essence, with green blood, is the key medicine of the qi-restoratives that nourishes blood;
The radix paeoniae rubrathe: bitter, cold nature, returns Liver Channel, has the function of clearing heat and cooling blood, blood stasis removing analgesic detumescence;
Rhizome of chuanxiong: pungent loose temperature is led to, can be promoting blood circulation and removing blood stasis, again can promoting qi circulation and relieving pain, is " the gas medicine in blood ", has effect of sensible qi and blood.
Embodiment 1
20g spray goods
(1) Radix Astragali, safflower, Radix Angelicae Sinensis, cultivated land, pseudo-ginseng, the radix paeoniae rubrathe, rhizome of chuanxiong Chinese herbal medicine extract are added dissolved in purified water after mixing, obtain mixed solution A, for subsequent use;
(2) flavouring essence for tobacco is mixed in proportion, add proper amount of edible glycerine and dissolve, obtain mixed solution B, (during use, taking exact mass as requested again) for subsequent use;
(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, ethyl-para-hydroxybenzoate (being commonly called as Nepal's ethyl ester), sucrose wherein, then quantitatively 20g is arrived with pure water, stir, by pH adjusting agent, goods pH value is adjusted to 7, then filling in spraying bottle, make finished product.
Result of use is evaluated: the mouth sprays goods organizing three tobacco evaluation and analysis librarian use embodiment of the present invention 1, experimental result shows, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and on average can continue 68min without smoking cigarette desire.
Embodiment 2
50g spray goods
The present embodiment preparation method is similar to embodiment 1, and raw material changes to some extent and then makes the content of active component in the tobacco of goods perfume and tobacco extract different.
(1) Radix Astragali, safflower, Radix Angelicae Sinensis, cultivated land, pseudo-ginseng, the radix paeoniae rubrathe, rhizome of chuanxiong Chinese herbal medicine extract are added dissolved in purified water after mixing, obtain mixed solution A, for subsequent use;
(2) flavouring essence for tobacco is mixed in proportion, add edible glycerol and dissolve, obtain mixed solution B, (during use, taking exact mass as requested again) for subsequent use;
(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, sorbic acid, sucrose wherein, then quantitatively arrive 50g with pure water, stir, by pH adjusting agent, goods pH value is adjusted to 8.9, then filling in spraying bottle, make finished product.
Result of use is evaluated: the mouth sprays goods organizing three tobacco evaluation and analysis librarian use embodiment of the present invention 2, experimental result shows, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and on average can continue 57min without smoking cigarette desire.
Embodiment 3
100g spray goods
1) Radix Astragali, safflower, Radix Angelicae Sinensis, cultivated land, pseudo-ginseng, the radix paeoniae rubrathe, rhizome of chuanxiong Chinese herbal medicine extract are added dissolved in purified water after mixing, obtain mixed solution A, for subsequent use;
(2) flavouring essence for tobacco is added edible glycerol to dissolve, obtain mixed solution B, (during use, taking exact mass as requested again) for subsequent use;
(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, Nepal's ethyl ester, sucrose wherein, then quantitatively arrive 100g with pure water, stir, by pH adjusting agent, goods pH value is adjusted to 9, then filling in spraying bottle, make finished product.
Result of use is evaluated: the mouth sprays goods organizing three tobacco evaluation and analysis librarian use embodiment of the present invention 3, experimental result shows, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and on average can continue 50min without smoking cigarette desire.
Embodiment 4
(1) 0.02% Astragalus Root P.E, 0.02% Notogineng Extract, 0.02% safflower extract, 0.02% angelica extract, 0.02% cultivated land extract, 0.02% red paeonia extract and 0.06% rhizome of chuanxiong extract are dissolved, obtain mixed solution A, for subsequent use;
(2) flavouring essence for tobacco of 1% is dissolved, obtain mixed solution B, for subsequent use;
(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, auxiliary material wherein, stir, regulate goods pH value by pH adjusting agent, then filling in spraying bottle, make finished product.
Embodiment 5
(1) 0.6% Astragalus Root P.E, 0.6% Notogineng Extract, 0.6% safflower extract, 0.6% cultivated land extract, 0.6% angelica extract, 0.6% red paeonia extract and 0.6% rhizome of chuanxiong extract are dissolved, obtain mixed solution A, for subsequent use;
(2) flavouring essence for tobacco of 10% is dissolved, obtain mixed solution B, for subsequent use;
(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, auxiliary material wherein, stir, regulate goods pH value to be 8 by pH adjusting agent, then filling in spraying bottle, make finished product.The anticorrisive agent of described auxiliary material is sodium sulfite, and sweetener is natural sugar; PH adjusting agent is citric acid.
Embodiment 6-17
Repeat embodiment 5, its difference is only, described anticorrisive agent is respectively propionic acid, propionic acid sodium salt, propionic acid calcium salt, p-hydroxybenzoate and sodium salt, Sodium Methyl Hydroxybenzoate, ethyl-para-hydroxybenzoate, P-hydroxybenzoic acid sodium salt, sorbic acid and sylvite, potassium metabisulfite, sodium pyrosulfite, sodium hydrogensulfite or Hydros.
Embodiment 18-20
Repeat embodiment 5, its difference is only, described pH adjusting agent is malic acid, sodium acid carbonate, sodium hydrogen phosphate.
Obviously; the above embodiment of the present invention is only for example of the present invention is clearly described; and be not the restriction to embodiments of the present invention; for those of ordinary skill in the field; can also make other changes in different forms on the basis of the above description; here cannot give exhaustive to all embodiments, every belong to technical scheme of the present invention the apparent change of extending out or variation be still in the row of protection scope of the present invention.
Claims (6)
1. an inrigorating qi and promoting blood circulation type tobacco oral spray agent, is characterized in that, comprises following material, counts by mass fraction: 0.14 ~ 4.2% Chinese herbal medicine extract; 5 ~ 30% tobacco extracts; 1 ~ 10% flavouring essence for tobacco; All the other are auxiliary material;
Described Chinese herbal medicine extract comprises 0.02 ~ 0.6% Astragalus Root P.E, 0.02 ~ 0.6% Notogineng Extract, 0.02 ~ 0.6% safflower extract, 0.02 ~ 0.6% angelica extract, 0.02 ~ 0.6% cultivated land extract, 0.02 ~ 0.6% red paeonia extract and 0.02 ~ 0.6% rhizome of chuanxiong extract;
Described tobacco extract to be nicotine content be 2.2 ~ 2.3% the material that extracts of tobacco leaf; One or more mixtures comprising flue-cured tobacco extract, air-curing of tobacco leaves extract or shine in tobacco extract; Described air-curing of tobacco leaves comprises burley tobaccos, Maryland and wrapper cigarette; Described suncured tabacco comprises Turkish tobaccos, Dark sun-cured, Sun cured tobacco and Nicotiniana rustica;
Described flavouring essence for tobacco comprises dorinone, β-damascone, 2; 6; 6-trimethyl-2-cyclohexene-1; 4-diketone, 2-hydroxyl-3; 5; 5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, 5 methyl furfural, benzaldehyde, phenylacetaldehyde, phenmethylol, palmitic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, phenylacetic acid, dihydroactinidiolide, dimethyl succinate, indoles, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine and 2; one or more mixtures in 3,5-trimethylpyrazine.
2. inrigorating qi and promoting blood circulation type tobacco oral spray agent according to claim 1, is characterized in that, described tobacco oral spray agent pH value is 7 ~ 9.
3. inrigorating qi and promoting blood circulation type tobacco oral spray agent according to claim 1, is characterized in that, described tobacco extract extracting method is as follows:
(1) preparation of tobacco extract: composite nicotine content is the tobacco material of 2.2 ~ 2.3%; Take above-mentioned tobacco material, add 75 ~ 80% alcohol refluxs and extract, solid-to-liquid ratio is 1:10 ~ 1:15, filters and get its filtrate after refluxing extraction 1 ~ 2h, and at 60 DEG C, water-bath concentrated filtrate, namely obtains tobacco extract; (2) by countercurrent chromatography instrument setting different solvents system, tobacco extract is separated; (3) cut appearance time is determined; (4) Fractional Collections effective active composition, obtains tobacco extract.
4. inrigorating qi and promoting blood circulation type tobacco oral spray agent according to claim 1, it is characterized in that, described auxiliary material comprise anticorrisive agent, sweetener, solvent and pH adjusting agent;
Described anticorrisive agent is any one in benzoic acid and sodium benzoate, propionic acid, propionic acid sodium salt, propionic acid calcium salt, p-hydroxybenzoate and sodium salt, sorbic acid and sylvite thereof, potassium metabisulfite, sodium pyrosulfite, sodium sulfite, sodium hydrogensulfite, Hydros;
Described sweetener is sugar or the natural sugar of one or more synthesis;
Described solvent is the mixture of pure water or pure water and edible glycerol;
Described pH adjusting agent is any one in citric acid, sorbic acid, malic acid, sodium acid carbonate, sodium hydrogen phosphate.
5. the preparation method of the inrigorating qi and promoting blood circulation type tobacco oral spray agent as described in Claims 1 to 4, is characterized in that, comprise following preparation process:
(1) Astragalus Root P.E, Notogineng Extract, safflower extract, angelica extract, cultivated land extract, red paeonia extract, rhizome of chuanxiong extract are dissolved, obtain mixed solution A, for subsequent use;
(2) flavouring essence for tobacco is dissolved in edible glycerol, obtains mixed solution B, for subsequent use;
(3) the mixed solution B of mixed solution A and exact mass is merged, add tobacco extract, auxiliary material wherein, stir, regulate goods pH value by pH adjusting agent, then filling in spraying bottle, make finished product.
6. the preparation method of inrigorating qi and promoting blood circulation type tobacco oral spray agent according to claim 5, is characterized in that, comprise the following steps:
(1) Radix Astragali, pseudo-ginseng, safflower, Radix Angelicae Sinensis, cultivated land, the radix paeoniae rubrathe, rhizome of chuanxiong seven taste Chinese herbal medicine extract are mixed rear dissolving, obtain mixed solution A, for subsequent use;
(2) flavouring essence for tobacco is dissolved in edible glycerol, obtains mixed solution B, for subsequent use;
(3) merged by the mixed solution B of mixed solution A and exact mass, add tobacco extract, other auxiliary material wherein, pure water is quantitative, stir, goods pH adjusting agent is adjusted to optimum pH, then filling in spraying bottle, make finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410027484.9A CN103798953B (en) | 2014-01-21 | 2014-01-21 | A kind of inrigorating qi and promoting blood circulation type tobacco oral spray agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410027484.9A CN103798953B (en) | 2014-01-21 | 2014-01-21 | A kind of inrigorating qi and promoting blood circulation type tobacco oral spray agent and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103798953A CN103798953A (en) | 2014-05-21 |
| CN103798953B true CN103798953B (en) | 2016-04-27 |
Family
ID=50696725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410027484.9A Active CN103798953B (en) | 2014-01-21 | 2014-01-21 | A kind of inrigorating qi and promoting blood circulation type tobacco oral spray agent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103798953B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105341996A (en) * | 2015-10-27 | 2016-02-24 | 深圳瀚星翔科技有限公司 | Electronic cigarette liquid and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586339A (en) * | 2004-09-13 | 2005-03-02 | 南阳卷烟厂 | Cigarette product containing Chinese herbal medicine |
| CN1961679A (en) * | 2005-11-08 | 2007-05-16 | 广州暨南大学医药生物技术研究开发中心 | A compound antivirus sprayer and preparation method thereof |
| CN101536812A (en) * | 2008-03-19 | 2009-09-23 | 马文孝 | Health-care cigarette and manufacturing method thereof |
| CN101671600A (en) * | 2009-09-23 | 2010-03-17 | 华宝食用香精香料（上海）有限公司 | Additives used in compound Chinese herbal medicine cigarette and use thereof |
| CN102028306A (en) * | 2010-12-07 | 2011-04-27 | 张志军 | Throat nourishing health-care type electronic cigarette liquid |
| RU2462108C1 (en) * | 2011-06-10 | 2012-09-27 | Олег Иванович Квасенков | Method for production of non-smoking products of tobacco (versions) |
-
2014
- 2014-01-21 CN CN201410027484.9A patent/CN103798953B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586339A (en) * | 2004-09-13 | 2005-03-02 | 南阳卷烟厂 | Cigarette product containing Chinese herbal medicine |
| CN1961679A (en) * | 2005-11-08 | 2007-05-16 | 广州暨南大学医药生物技术研究开发中心 | A compound antivirus sprayer and preparation method thereof |
| CN101536812A (en) * | 2008-03-19 | 2009-09-23 | 马文孝 | Health-care cigarette and manufacturing method thereof |
| CN101671600A (en) * | 2009-09-23 | 2010-03-17 | 华宝食用香精香料（上海）有限公司 | Additives used in compound Chinese herbal medicine cigarette and use thereof |
| CN102028306A (en) * | 2010-12-07 | 2011-04-27 | 张志军 | Throat nourishing health-care type electronic cigarette liquid |
| RU2462108C1 (en) * | 2011-06-10 | 2012-09-27 | Олег Иванович Квасенков | Method for production of non-smoking products of tobacco (versions) |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103798953A (en) | 2014-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103768435B (en) | A kind of fresh breath type tobacco oral spray agent and preparation method thereof | |
| CN103113989B (en) | Tobacco essence capable of improving cigarette taste and aroma | |
| CN103750538B (en) | A kind of throat-clearing throat-moistening type tobacco oral spray agent and preparation method thereof | |
| CN104983066B (en) | A kind of substitute of tobacco and preparation method thereof | |
| CN104957298A (en) | Health preserving jasminum sambac flower tea | |
| CN106539124B (en) | A kind of preparation method of cigarette filter tip additive | |
| CN103564647A (en) | Preparation method of traditional Chinese medicine spices for tobaccos | |
| CN103343053B (en) | Tobacco essence capable of improving cigarette taste and fragrance | |
| CN101843364B (en) | Spice additive for natural cigarettes and preparation method thereof | |
| CN106539125B (en) | A kind of sweetened humectant additive of cigarette shreds and preparation method thereof | |
| CN103750539B (en) | A kind of antiphlogistic antibacterial type tobacco nasal spray composition and method of making the same | |
| CN103734904B (en) | A kind of nourishing Yin and falling fire type tobacco oral spray agent and preparation method thereof | |
| CN103768367B (en) | A kind of expelling phlegm for arresting cough type tobacco oral spray agent and preparation method thereof | |
| CN103798953B (en) | A kind of inrigorating qi and promoting blood circulation type tobacco oral spray agent and preparation method thereof | |
| CN101803799A (en) | Gypenoside-contained cigarette and manufacture method thereof | |
| CN106668294A (en) | Salvia miltiorrhiza leaf composite healthcare tea having efficacies for reducing blood glucose, reducing blood fat and lowering blood pressure and preparation method and use of salvia miltiorrhiza composite leaf healthcare tea | |
| CN110771944A (en) | Apocynum venetum health-care cigarette and preparation method thereof | |
| CN103271441B (en) | Application of moringa oleifera seed extractive to cigarette filter stick and cigarette filter stick | |
| CN108552373A (en) | A kind of reducing blood lipid and blood pressure reducing health-care tea and preparation method thereof | |
| CN103751252A (en) | Antiseptic disinfectant wash-free type tobacco gel composition and preparation method thereof | |
| CN103798952B (en) | Sensible type tobacco nasal spray composition and method of making the same of refreshing oneself | |
| CN103767063B (en) | A kind of anti-blooming antiemetic type tobacco oral spray agent and preparation method thereof | |
| CN103750540B (en) | A kind of antiphlogistic antibacterial type tobacco oral spray agent and preparation method thereof | |
| Bakhru | Indian spices & condiments as natural healers | |
| CN103767061B (en) | A kind of preventing decayed tooth is good for flute profile tobacco oral spray agent and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |