CN103768367B - A kind of expelling phlegm for arresting cough type tobacco oral spray agent and preparation method thereof - Google Patents

Abstract

The open a kind of expelling phlegm for arresting cough type tobacco oral spray agent of the present invention, including following material, be in parts by weight: 5 30% tobacco extracts；0.14 4.2% Chinese herbal medicine extract；1 10% flavouring essence for tobacco；Remaining is auxiliary material；Wherein, described Chinese medicine extract is the extract of the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis；This spray had both been provided that user was equal to suck the gratification of traditional cigarette and also has second effect of expelling phlegm for arresting cough.The invention also discloses the preparation method of a kind of expelling phlegm for arresting cough type tobacco oral spray agent.

Description

A kind of expelling phlegm for arresting cough type tobacco oral spray agent and preparation method thereof

Technical field

The present invention relates to Field of Tobacco, more particularly to a kind of expelling phlegm for arresting cough type tobacco oral spray agent and system thereof Preparation Method.

Background technology

Gas phase aerosol mutually two-part with grain can be produced after the traditional cigarette burning circulated in the market. Gas phase portion accounts for the 92% of whole flue gas mass, and grain part mutually accounts for 8%.In this two parts aerosol Some compositions pollute the environment, additionally, the stub after smoking there is also the possibility of initiation fire.

Along with the step of international Tobacco Control campaign is more accelerated, national governments to smoking especially to public place The restriction of smoking is further strict, and has gradually formed social consensus.Under the strictest Tobacco Control environment, Partial Tobacco consumer may select new non-traditional tobacco product, and this variation tendency is the most clear Clear.Show according to statistical data in 2011, while worldwide Medicated cigarette volume of production and marketing has declined, Other types tobacco product presents quick growth trend.It is estimated that the non-traditional tobacco product in the world in 2011 Market sale total value is about 60,000,000,000 dollars, and wherein smoke-free tobacco product is about 16,000,000,000 dollars, becomes One the rising forces on World tobacco market.Therefore, Novel smokeless gas Nicotiana tabacum L. is researched and developed further Seem particularly necessary.

Cough is a kind of protectiveness respiratory reflex action of human body.Breathing can be effectively removed by coughre flex Secretions in road or the foreign body of entrance air flue, but acutely cough may result in respiratory tract hemorrhage, long term frequent Cough tempestuously and not only can affect work and rest, even can cause laryngalgia, hoarseness and breathing myalgia, this Time aspirate again traditional cigarette undoubtedly can increase the weight of cough phenomenon.The medicine being currently used for treatment cough is divided into Western medicine Class big with Chinese medicine two.Compared with Western medicine, Chinese medicine also has resolve phlegm effect while cough-relieving, its property of medicine temperature Little with, side effect, although to take effect be not as rapid as Western medicine, but take stopgap measures and effect a permanent cure.

Summary of the invention

First technical problem that the invention solves the problems that is to provide a kind of expelling phlegm for arresting cough type tobacco oral spray agent, Including following material, it is in parts by weight: 5-30% tobacco extract；0.14-4.2% Chinese herbal medicine extracting Thing；1-10% flavouring essence for tobacco；Remaining is auxiliary material；Wherein, described Chinese medicine extract is the Radix Astragali, Fu The extract of Siberian cocklebur, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis；This spray had both been provided that and had made User is equal to suck the gratification of traditional cigarette and also has second effect of expelling phlegm for arresting cough.

Second technical problem that the invention solves the problems that is to provide a kind of expelling phlegm for arresting cough type tobacco oral spray agent Preparation method.

The present invention uses following technical proposals:

A kind of expelling phlegm for arresting cough type tobacco oral spray agent, including following material, be in parts by weight: 5-30% Tobacco extract；0.14-4.2% Chinese herbal medicine extract；1-10% flavouring essence for tobacco；Remaining is auxiliary material； Wherein, described Chinese medicine extract is the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and five The extract of taste.

Preferably, described Chinese herbal medicine extract is: 0.02-0.6% Radix Astragali extract, 0.02-0.6% Poria carry Take thing, 0.02-0.6% Exocarpium Citri Rubrum extract, 0.02-0.6% Flos Lonicerae extract, 0.02-0.6% Herba Houttuyniae carry Take thing, 0.02-0.6% Bulbus Fritillariae Cirrhosae extract and 0.02-0.6% Fructus Schisandrae Chinensis extrat.

Preferably, the pH value of described tobacco oral spray agent is 7～9；It is highly preferred that described Nicotiana tabacum L. oral cavity The pH value of spray is 9.Nicotine is one of main active in tobacco extract, and nicotine is inhaled from oral cavity Take in and depend on saliva, the pH of blood plasma and the acid-base balance of nicotine into human circulation.The soda acid of nicotine is put down It is 7.8 that weighing apparatus is about pH at 37 DEG C.Assuming that the pH of saliva is 6.8, the nicotine of the most about 10% will For uncharged alkali form.Therefore, in order to promote nicotine, with free alkali form, (it is for mainly passing through mucosa The form absorbed) absorb, it is necessary to increase the pH of saliva.When pH is 9.0, the nicotine more than 90% Would is that the free alkali form of easily absorption.

Described tobacco extract is from Nicotiana tabacum L. the Nicotiana tabacum L. effective active composition extracted, and refers to contain in Nicotiana tabacum L. Based on alcohol, aldehyde, ketone, ester, hydro carbons, heterocyclic tobacco flavor material (benzyl alcohol, phytol, West uncle three enediols, 3-methyl-2-butene aldehyde, benzaldehyde, solanone, Megastigmatrienone, dihydro-actinidia Lactone, methyl hexadecanoate, ethyl palmitate, neophytadiene, pyridine etc.) and other biological active matter Matter, such as alkaloid, Salanesol, protein, aminoacid and saccharide etc..

Preferably, described tobacco extract is flue-cured tobacco extract, air-curing of tobacco leaves extract, shines in tobacco extract One or more mixture；Described air-curing of tobacco leaves is burley tobaccos, Maryland, wrapper cigarette；Described Suncured tabacco is Turkish tobaccos, Dark sun-cured, Sun cured tobacco, Nicotiniana rustica；In Nicotiana tabacum L., the content of nicotine is 2.2～2.3%.

Preferably, described tobacco extract is through the following steps that obtain: the 1) preparation of tobacco extract: By compounding raw material, it is ensured that in raw tobacco, nicotine content is 2.2～2.3%, accurately weighs Nicotiana tabacum L. powder-like Product, add 75-80% alcohol reflux, and solid-to-liquid ratio is 1:10～15, filter after reflux, extract, 1～2h And take its filtrate, at 55～65 DEG C, water-bath concentrated filtrate, obtains tobacco extract；2) high by preparative Speed counter-current chromatograph sets different solvents system and separates tobacco extract；3) determine that fraction goes out peak Time；4) Fractional Collections effective active composition, obtains tobacco extract.

High-speed counter-current chromatograph is to can be used for alkaloid compound in Nicotiana tabacum L., flavone compound, terpenoid Compound, organic acid compound, lignin and coumarin kind compound, quinones separation with The instrument extracted.

Active component in Chinese herbal medicine extract, as a example by Flos Lonicerae, volatile oil (palm fibre present in Flos Lonicerae Palmitic acid acid, aromatic alcohol, aromadendrene, linalool and geraniol), flavonoid (luteolin-7-O-α-D Portugal Polyglycoside, luteolin-7-O-β-D-galactoside, Quercetin-3-O-β-D-Glucose glycosides, Radix Hyperici Monogyni (Herba Hyperici Monogyni) Glycosides), organic acid (chlorogenic acid, isochlorogenic acid and caffeic acid), triterpenes (largeflower-like honeysuckle flower saponin first, Largeflower-like honeysuckle flower saponin second, dipsacoside) etc. functional component be exactly its play many effects activity Composition.

Described Chinese herbal medicine extract can directly buy acquisition by market, it is possible to extracts voluntarily.Extract voluntarily Time, can take indescribably by each Chinese medicine, finally mix, it is possible to once extract the mixture of each Chinese medicine.

The equal integration of edible and medicinal herbs of Chinese herbal medicine related in the present invention.

Preferably, described Chinese herbal medicine extract extracts according to following steps:

By each raw material of Chinese medicine mix homogeneously, impregnating in 70 DEG C～75 DEG C of pure water, solid-to-liquid ratio is 1: 10～15, its filtrate is filtered and taken to ultrasonic extraction after extracting 1～3h, and filtering residue adds the water of 7～9 multiple doses Continue supersound extraction 1～3h and filter and take its filtrate, merge twice filtrate；Filtrate is added rotary evaporation Stop concentrating when instrument is concentrated into the 1/3～2/3 of filtrate volume, cooling concentration liquid, obtain Chinese herbal medicine and slightly carry Liquid；Centrifugal Chinese herbal medicine crude extract, takes supernatant, obtains Chinese herbal medicine extract.

Described Chinese herbal medicine select be dried, free from insect pests, without go rotten, the Chinese herbal medicine of free from extraneous odour, size-reduced machine powder Extract after broken.

Those skilled in the art can select the flavouring essence for tobacco being suitable for as required.Specifically, first pass through Head space distillation-GC/MS carries out qualitative and quantitative analysis or with Cambridge to the fragrance matter of dissimilar Nicotiana tabacum L. Filter disc collects flue-cured tobacco total particulate matter in mainstream smoke, uses GC/MS to carry out the fragrance matter of main flume fixed Property quantitative analysis, and then tentatively draft the kind of the flavouring essence for tobacco with tobacco note, adjust different material Adding proportion, debate perfume (or spice) through cigarette perfume (or spice) Shi Fanfu, determine the flavouring essence for tobacco with tobacco note kind and Adding proportion.Preferably, described flavouring essence for tobacco is dorinone, β-damascone, 2,6,6-trimethyls -2-cyclohexene-1,4-diketone, 2-hydroxyl-3,5,5-trimethyl-2-cyclonene, geranyl acetone, β-purple sieve Blue ketone, furfural, 5 methyl furfural, benzaldehyde, hyacinthin, benzyl alcohol, Palmic acid, isovaleric acid, 2- Methylvaleric acid, acetic acid, phenylacetic acid, dihydroactinidiolide, dimethyl succinate, indole, pyridine, One or both in 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine, 2,3,5-trimethylpyrazine Thing mixed above.

Those skilled in the art can select the auxiliary material being suitable for as required.Preferably, described auxiliary material Material includes preservative, pH adjusting agent, sweeting agent, solvent.Amount ratio between various auxiliary materials without Must limit, those skilled in the art can select according to actual needs.

It is highly preferred that described preservative be benzoic acid and sodium benzoate, propanoic acid and sodium salt thereof or calcium salt, to hydroxyl Yl benzoic acid esters and sodium salt (Sodium Methyl Hydroxybenzoate, ethylparaben and sodium thereof Salt), sorbic acid and potassium salt, potassium metabisulfite, sodium pyrosulfite, sodium sulfite, sodium sulfite Or Hydros.The consumption of preservative uses the rule of standard according to GB2760-2011 food additive Fixed.

Described pH adjusting agent is citric acid, sorbic acid, malic acid, sodium bicarbonate or disodium hydrogen phosphate.

Described sweeting agent is sugar or the natural sugar of one or more synthesis, is i.e. suitable as any of sweeting agent The saccharide of form.

Described solvent is pure water or pure water and the mixture of edible glycerol.

Add edible glycerol be in order to dissolve some not/be insoluble in the flavouring essence for tobacco of water, such as dorinone, β-damascone, 2,6,6-trimethyl-2-cyclohexene-1,4-diketone, geranyl acetone, benzaldehyde, benzene second Aldehyde, Palmic acid, dihydroactinidiolide.The amount of edible glycerol meets dissolves flavouring essence for tobacco.

The spray of the present invention can use the various dosage strengths of 20g, 50g, 100g etc. to pack.

The preparation method of a kind of expelling phlegm for arresting cough type tobacco oral spray agent, comprises the following steps:

1) by Radix Astragali extract, Poria extract, Exocarpium Citri Rubrum extract, Flos Lonicerae extract, Herba Houttuyniae Extract, Bulbus Fritillariae Cirrhosae extract and Fructus Schisandrae Chinensis extrat dissolve, and obtain mixed solution A, standby；

2) flavouring essence for tobacco is dissolved, obtain mixed solution B, standby；

3) mixed solution A and mixed solution B are merged, be added thereto to tobacco extract, auxiliary material Material, stirs, and pH is to optimum pH in regulation, and then fill is in spraying bottle, makes finished product.

The preparation method of a kind of expelling phlegm for arresting cough type tobacco oral spray agent, comprises the following steps:

1) by the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis seven taste medium-height grass The extract mix homogeneously of medicine, adds dissolved in purified water, obtains mixed solution A, standby；

2) by flavouring essence for tobacco, add proper amount of edible glycerol and dissolve, obtain mixed solution B, standby；

3) the mixed solution B of mixed solution A and exact mass is merged, be added thereto to Nicotiana tabacum L. and extract Thing, other assist material, pure water is quantitative, stirs, by goods with pH adjusting agent regulation to suitable Preferably pH value, then fill is in spraying bottle, makes finished product.

Beneficial effects of the present invention is as follows:

1, the spray environmental protection of the present invention, smokeless, except being provided that user is equal to suck conventional roll Also there is outside the gratification of cigarette second effect of expelling phlegm for arresting cough.

2, the commonly used present invention of tobacco consumer this not by treatment disease for the purpose of expelling phlegm for arresting cough mouth Chamber spray can play a role in health care, it is often more important that tobacco consumer uses these goods not in cough the most in good time Only do not interfere with disease, also can assist and improve throat discomfort symptom；There is not yet this type of both at home and abroad at present to dispel The report of phlegm and relieving cough type tobacco oral spray agent formula, the present invention has broad application prospects.

3, the preparation of the present invention can make user obtain being equal to suck the gratification of traditional cigarette, again Expelling phlegm for arresting cough effect of Chinese herbal medicine active component can be enjoyed, it is also possible to avoid traditional cigarette to burn to environment Impact and second hand smoking to non-smokers and the harm of tobacco consumer self, its research and development and manufacture Technical research is to accelerating Nicotiana tabacum L. scientific and technological progress, promoting cigarette brand and be worth and tackle new Tobacco Control situation and have Important realistic meaning.

4, the present invention is not only suitable for male, is also applied for women, and user uses and do not has medicine association But the means relevant to life just can enjoy expelling phlegm for arresting cough effect of medicinal herb components in formula.

5, flavouring essence for tobacco be provided that cigarette consumption person's olfactory sensation, sense of taste gratification is added.

6, compatibility of the present invention is reasonable, it is easy to manufacturing, the goods of spray-type are easy to carry, uses health, The spray goods of the present invention both can be as the interim succedaneum of ban on opium-smoking and the opium trade place traditional cigarette, it is also possible to become A kind of preferably novel environment friendly functional type smoke-free tobacco product when coughing in smoker's daily life.

Detailed description of the invention

In order to be illustrated more clearly that the present invention, below in conjunction with preferred embodiment, the present invention is done further Bright.

The Radix Astragali, Poria: replenishing QI to invigorate the spleen, get rid of evils and go out.

Flos Lonicerae, Herba Houttuyniae: heat-clearing and toxic substances removing, have antibacterial, antiinflammatory action.

Exocarpium Citri Rubrum: regulate the flow of vital energy and in, drying dampness to eliminate phlegm.

Bulbus Fritillariae Cirrhosae: the multiple alkaloid included and non-alkaloid part all have relieving cough and expelling phlegm, heat clearing away eliminating stagnation to make With.

Fructus Schisandrae Chinensis: nourishing kidney of astringing the lung, promote the production of body fluid arresting sweating.

Embodiment 1

Preparation 20g spray goods:

(1) by the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis seven taste Add 10g dissolved in purified water after herb extracts mix homogeneously, obtain mixed solution A, standby；

(2) the flavouring essence for tobacco mix homogeneously that will weigh in ratio in upper table, adds proper amount of edible glycerol molten Solve, obtain mixed solution B, standby (further according to requiring to weigh exact mass during use)；

(3) the mixed solution B of mixed solution A and exact mass is merged, be added thereto to Nicotiana tabacum L. and carry Taking thing, Nepal's ethyl ester, sucrose, pure water quantitatively arrives 20g, stirs, will by pH adjusting agent Goods regulate to optimum pH, and then fill is in spraying bottle, makes finished product.

Using effect is evaluated: organize the oral cavity spray containing 30% tobacco extract of three Nicotiana tabacum L. evaluation and analysis librarian uses Agent goods, test result indicate that, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks 0.4g These goods, after average 2min, smoking cigarette desire disappears, and can averagely continue without smoking cigarette desire 66min。

Embodiment 2

Preparation 50g spray goods:

(1) by the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis seven taste Add 30g dissolved in purified water after herb extracts mix homogeneously, obtain mixed solution A, standby；

(2) the flavouring essence for tobacco mix homogeneously that will weigh in ratio in upper table, adds proper amount of edible glycerol molten Solve, obtain mixed solution B, standby (further according to requiring to weigh exact mass during use)；

(3) the mixed solution B of mixed solution A and exact mass is merged, be added thereto to Nicotiana tabacum L. and carry Taking thing, sorbic acid, sucrose, pure water quantitatively arrives 50g, stirs, by pH adjusting agent by goods Regulation is to optimum pH, and then fill is in spraying bottle, makes finished product.

Using effect is evaluated: organize the oral cavity spray containing 25% tobacco extract of three Nicotiana tabacum L. evaluation and analysis librarian uses Agent goods, test result indicate that, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks 0.4g These goods, after average 2min, smoking cigarette desire disappears, and can averagely continue without smoking cigarette desire 57min。

Embodiment 3

Preparation 100g spray goods:

(1) by the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis seven taste Add 65g dissolved in purified water after herb extracts mix homogeneously, obtain mixed solution A, standby；

(2) the flavouring essence for tobacco mix homogeneously that will weigh in ratio in upper table, adds proper amount of edible glycerol molten Solve, obtain mixed solution B, standby (further according to requiring to weigh exact mass during use)；

(3) the mixed solution B of mixed solution A and exact mass is merged, be added thereto to Nicotiana tabacum L. and carry Taking thing, Nepal's ethyl ester, sucrose, pure water quantitatively arrives 100g, stirs, will by pH adjusting agent Goods regulate to optimum pH, and then fill is in spraying bottle, makes finished product.

Using effect is evaluated: organize the oral cavity spray containing 20% tobacco extract of three Nicotiana tabacum L. evaluation and analysis librarian uses Agent goods, test result indicate that, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks 0.4g These goods, after average 2min, smoking cigarette desire disappears, and can averagely continue without smoking cigarette desire 48min。

Embodiment 4

A kind of expelling phlegm for arresting cough type tobacco oral spray agent, including following material, be in parts by weight: 5% cigarette Grass extract；0.14% Chinese herbal medicine extract；1% flavouring essence for tobacco；Remaining is auxiliary material；Wherein, institute Stating Chinese medicine extract is carrying of the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis Take thing.

Described tobacco extract is the extract of flue-cured tobacco, through the following steps that obtain: 1) Nicotiana tabacum L. carries Take the preparation of liquid: in flue-cured tobacco, nicotine content is 2.2～2.3%, accurately weigh Nicotiana tabacum L. powder sample, add 75% Alcohol reflux, solid-to-liquid ratio is 1:10, filters and take its filtrate, at 55 DEG C after reflux, extract, 1h Water-bath concentrated filtrate, obtains tobacco extract；2) difference is set by countercurrent chromatography instrument Tobacco extract is separated by dicyandiamide solution；3) fraction appearance time is determined；4) Fractional Collections is effective Active component, obtains tobacco extract.

Described Chinese herbal medicine extract extracts according to following steps: by each raw material of Chinese medicine mix homogeneously, Impregnating in 70 DEG C of pure water, solid-to-liquid ratio is 1:10, and its filtrate is filtered and taken to ultrasonic extraction after extracting 1h, Filtering residue adds water continuation supersound extraction 1h of 7 multiple doses and filters and take its filtrate, merges twice filtrate； Stop concentrating when filtrate adds in Rotary Evaporators be concentrated into filtrate volume 1/3, cooling concentration liquid, Obtain Chinese herbal medicine crude extract；Centrifugal Chinese herbal medicine crude extract, takes supernatant, obtains Chinese herbal medicine extract.

Described flavouring essence for tobacco is dorinone, β-damascone, 2,6,6-trimethyl-2-cyclohexene-1,4- Diketone, 2-hydroxyl-3,5,5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, The mixture (mass ratio 1:2.5:0.5:2:2:3:1.5:2) of 5 methyl furfural.

Described auxiliary material includes preservative sodium benzoate, pH adjusting agent citric acid, sweeting agent, solvent (water and the mixture of edible glycerol).

Embodiment 5

A kind of expelling phlegm for arresting cough type tobacco oral spray agent, including following material, be in parts by weight: 5% cigarette Grass extract；0.6% Radix Astragali extract, 0.6% Poria extract, 0.6% Exocarpium Citri Rubrum extract, 0.6% gold silver Flower extract, 0.6% Herba Houttuyniae extract, 0.6% Bulbus Fritillariae Cirrhosae extract, 0.6% Fructus Schisandrae Chinensis extrat；3% Flavouring essence for tobacco；Remaining is auxiliary material.The pH value of described tobacco oral spray agent is 7.

Described tobacco extract is burley tobaccos, Maryland and the extract of wrapper cigarette, be by with Lower step obtains: the 1) preparation of tobacco extract: by compounding raw material, it is ensured that in Nicotiana tabacum L., nicotine contains Amount, 2.2～2.3%, accurately weighs Nicotiana tabacum L. powder sample, adds 75-80% alcohol reflux, solid-liquid Ratio is 1:10～15, filters and take its filtrate after reflux, extract, 1～2h, and at 55～65 DEG C, water-bath concentrates filter Liquid, obtains tobacco extract；2) different solvents system pair is set by countercurrent chromatography instrument Tobacco extract separates；3) fraction appearance time is determined；4) Fractional Collections effective active composition, Obtain tobacco extract.

Described Chinese herbal medicine extract extracts according to following steps: by each raw material of Chinese medicine mix homogeneously, Impregnating in 75 DEG C of pure water, solid-to-liquid ratio is 1:15, and its filtrate is filtered and taken to ultrasonic extraction after extracting 3h, Filtering residue adds water continuation supersound extraction 3h of 9 multiple doses and filters and take its filtrate, merges twice filtrate； Stop concentrating when filtrate adds in Rotary Evaporators be concentrated into filtrate volume 2/3, cooling concentration liquid, Obtain Chinese herbal medicine crude extract；Centrifugal Chinese herbal medicine crude extract, takes supernatant, obtains Chinese herbal medicine extract.

Described flavouring essence for tobacco is benzaldehyde, hyacinthin, benzyl alcohol, Palmic acid, isovaleric acid, 2-methylpent Acid, acetic acid, phenylacetic acid, dihydroactinidiolide mixture (mass ratio 1:2.5:0.5:2:2: 3:1.5:2:1).

Described auxiliary material includes preservative propanoic acid, pH adjusting agent malic acid, sweeting agent, solvent (water Mixture with edible glycerol).

Embodiment 6

A kind of expelling phlegm for arresting cough type tobacco oral spray agent, including following material, be in parts by weight: 30% Tobacco extract；0.02% Radix Astragali extract, 0.02% Poria extract, 0.02% Exocarpium Citri Rubrum extract, 0.2% Flos Lonicerae extract, 0.2% Herba Houttuyniae extract, 0.2% Bulbus Fritillariae Cirrhosae extract, 0.3% Fructus Schisandrae Chinensis extrat； 10% flavouring essence for tobacco；Remaining is auxiliary material.The pH value of described tobacco oral spray agent is 8.

Described tobacco extract is the extract of Turkish tobaccos, Dark sun-cured, Sun cured tobacco and Nicotiniana rustica, is to pass through Following steps obtain: the 1) preparation of tobacco extract: by compounding raw material, it is ensured that nicotine in Nicotiana tabacum L. Content, 2.2～2.3%, accurately weighs Nicotiana tabacum L. powder sample, adds 78% alcohol reflux, solid-to-liquid ratio For 1:12, filtering and take its filtrate after reflux, extract, 1.5h, at 60 DEG C, water-bath concentrated filtrate, obtains cigarette Grass extracting solution；2) different solvents system is set to tobacco extract by countercurrent chromatography instrument Separate；3) fraction appearance time is determined；4) Fractional Collections effective active composition, obtains Nicotiana tabacum L. and carries Take thing.

Described Chinese herbal medicine extract extracts according to following steps: by each raw material of Chinese medicine mix homogeneously, Impregnating in 72 DEG C of pure water, solid-to-liquid ratio is 1:12, and its filtrate is filtered and taken to ultrasonic extraction after extracting 2h, Filtering residue adds water continuation supersound extraction 2h of 8 multiple doses and filters and take its filtrate, merges twice filtrate； Stop concentrating when filtrate adds in Rotary Evaporators be concentrated into filtrate volume 1/2, cooling concentration liquid, Obtain Chinese herbal medicine crude extract；Centrifugal Chinese herbal medicine crude extract, takes supernatant, obtains Chinese herbal medicine extract.

Described flavouring essence for tobacco is dimethyl succinate, indole, pyridine, 3-acetylpyridine, 3-ethyl pyrrole Mixture in pyridine, 2-methylpyrazine, 2,3,5-trimethylpyrazine (mass ratio 2.5:0.5:2:2:3: 1.5:1).

Described auxiliary material includes preservative sorbic acid, pH adjusting agent sodium bicarbonate, sweeting agent, solvent (water and the mixture of edible glycerol).

Embodiment 7

With embodiment 6, difference is: preservative be potassium metabisulfite, pH adjusting agent be sorbic acid.

Embodiment 8

With embodiment 6, difference is: preservative be sodium pyrosulfite, pH adjusting agent be disodium hydrogen phosphate.

Embodiment 9

With embodiment 6, difference is: preservative is sodium sulfite.

Embodiment 10

With embodiment 6, difference is: preservative is sodium sulfite.

Embodiment 11

With embodiment 6, difference is: preservative is Hydros.

Embodiment 12

With embodiment 6, difference is: preservative is p-Hydroxybenzoate.

Embodiment 13

With embodiment 6, difference is: preservative is ethylparaben.

Embodiment 14

With embodiment 6, difference is: preservative is nipagin A sodium salt.

Obviously, the above embodiment of the present invention is only for clearly demonstrating example of the present invention, and It is not the restriction to embodiments of the present invention, for those of ordinary skill in the field, Can also make other changes in different forms on the basis of described above, here cannot be to all Embodiment give exhaustive, every belong to the obvious change that technical scheme extended out Change or change the row still in protection scope of the present invention.

Claims (9)

1. an expelling phlegm for arresting cough type tobacco oral spray agent, it is characterised in that include following material, by matter Amount mark is calculated as: 5-30% tobacco extract；0.14-4.2% Chinese herbal medicine extract；1-10% flavouring essence for tobacco； Remaining is auxiliary material；Wherein, described Chinese herbal medicine extract be the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, The extract of Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis；

Described Chinese herbal medicine extract is: 0.02-0.6% Radix Astragali extract, 0.02-0.6% Poria extract, 0.02-0.6% Exocarpium Citri Rubrum extract, 0.02-0.6% Flos Lonicerae extract, 0.02-0.6% Herba Houttuyniae extract, 0.02-0.6% Bulbus Fritillariae Cirrhosae extract and 0.02-0.6% Fructus Schisandrae Chinensis extrat；

Described auxiliary material includes preservative, pH adjusting agent, sweeting agent and solvent；

Described preservative is benzoic acid and sodium benzoate, propanoic acid and sodium salt thereof or calcium salt, P-hydroxybenzoic acid Esters and sodium salt, sorbic acid and potassium salt thereof, potassium metabisulfite, sodium pyrosulfite, sodium sulfite, Sodium sulfite or Hydros；

Described pH adjusting agent is citric acid, sorbic acid, malic acid, sodium bicarbonate or disodium hydrogen phosphate；

Described sweeting agent is sugar or the natural sugar of one or more synthesis；

Described solvent is pure water or pure water and the mixture of edible glycerol.

Expelling phlegm for arresting cough type tobacco oral spray agent the most according to claim 1, it is characterised in that institute The pH value stating tobacco oral spray agent is 7～9.

Expelling phlegm for arresting cough type tobacco oral spray agent the most according to claim 1, it is characterised in that institute The pH value stating tobacco oral spray agent is 9.

Expelling phlegm for arresting cough type tobacco oral spray agent the most according to claim 1, it is characterised in that institute State tobacco extract be flue-cured tobacco extract, air-curing of tobacco leaves extract, shine in tobacco extract one or both with Upper mixture；Described air-curing of tobacco leaves is burley tobaccos, Maryland, wrapper cigarette；Described suncured tabacco is spice Cigarette, Dark sun-cured, Sun cured tobacco, Nicotiniana rustica；Wherein, nicotine in the Nicotiana tabacum L. of flue-cured tobacco or air-curing of tobacco leaves or suncured tabacco Content is 2.2～2.3%.

Expelling phlegm for arresting cough type tobacco oral spray agent the most according to claim 1, it is characterised in that institute State tobacco extract through the following steps that obtain: 1) preparation of tobacco extract: by compounding former Material, it is ensured that in raw tobacco, nicotine content is 2.2～2.3%, accurately weighs Nicotiana tabacum L. powder sample, adds 75-80% alcohol reflux, solid-to-liquid ratio is 1:10～15, filters and take it after reflux, extract, 1～2h Filtrate, at 55～65 DEG C, water-bath concentrated filtrate, obtains tobacco extract；2) inverse by preparative high speed Flow chromatography instrument sets different solvents system and separates tobacco extract；3) fraction appearance time is determined； 4) Fractional Collections effective active composition, obtains tobacco extract.

Expelling phlegm for arresting cough type tobacco oral spray agent the most according to claim 1, it is characterised in that institute State flavouring essence for tobacco be dorinone, β-damascone, 2,6,6-trimethyl-2-cyclohexene-1,4-diketone, 2-hydroxyl-3,5,5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, 5-methyl Furfural, benzaldehyde, hyacinthin, benzyl alcohol, Palmic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, benzene Acetic acid, dihydroactinidiolide, dimethyl succinate, indole, pyridine, 3-acetylpyridine, 3- One or more mixture in ethylpyridine, 2-methylpyrazine, 2,3,5-trimethylpyrazine.

Expelling phlegm for arresting cough type tobacco oral spray agent the most according to claim 1, it is characterised in that institute State this formate ester of hydroxyl and sodium salt thereof is methyl parahydroxybenzoate and sodium salt, para hydroxybenzene first Acetoacetic ester and sodium salt thereof.

8. the preparation method of the expelling phlegm for arresting cough type tobacco oral spray agent as described in as arbitrary in claim 1～7, It is characterized in that, comprise the following steps:

1) by Radix Astragali extract, Poria extract, Exocarpium Citri Rubrum extract, Flos Lonicerae extract, Herba Houttuyniae Extract, Bulbus Fritillariae Cirrhosae extract and Fructus Schisandrae Chinensis extrat dissolve, and obtain mixed solution A, standby；

2) flavouring essence for tobacco adds edible glycerol dissolve, obtain mixed solution B, standby；

3) mixed solution A and mixed solution B are merged, be added thereto to tobacco extract, auxiliary material Material, stirs, and pH is to optimum pH in regulation, and then fill is in spraying bottle, makes finished product.

The preparation method of expelling phlegm for arresting cough type tobacco oral spray agent the most according to claim 8, it is special Levy and be, comprise the following steps:

1) by the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis seven taste medium-height grass The extract mix homogeneously of medicine, adds dissolved in purified water, obtains mixed solution A, standby；

2) flavouring essence for tobacco adds edible glycerol dissolve, obtain mixed solution B, standby；

3) the mixed solution B of mixed solution A and exact mass is merged, be added thereto to Nicotiana tabacum L. and extract Thing, other assist material, pure water is quantitative, stirs, by goods with pH adjusting agent regulation to suitable Preferably pH value, then fill is in spraying bottle, makes finished product.