CN103768367A - Tobacco oral spray for expelling phlegm to arrest coughing and preparation method thereof - Google Patents
Tobacco oral spray for expelling phlegm to arrest coughing and preparation method thereof Download PDFInfo
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- CN103768367A CN103768367A CN201410028227.7A CN201410028227A CN103768367A CN 103768367 A CN103768367 A CN 103768367A CN 201410028227 A CN201410028227 A CN 201410028227A CN 103768367 A CN103768367 A CN 103768367A
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Abstract
The invention discloses a tobacco oral spray for expelling phlegm to arrest coughing. The tobacco oral spray comprises the following substances in parts by mass: 5-30% of tobacco extract, 0.14-4.2% of Chinese herb extracts, 1-10% of tobacco flavor, and the balance of auxiliary materials, wherein the Chinese herb extracts are extracts of astragalus membranaceus, poria cocos, chrysoidine, honeysuckle, herba houttuyniae, fritillaria and fructus schizandrae. The spray can provide satisfaction equal to taking in the traditional cigarette to a user, and also has a second effect of expelling phlegm to arrest coughing. A preparation method of the tobacco oral spray for expelling phlegm to arrest coughing is also disclosed by the invention.
Description
Technical field
The present invention relates to Field of Tobacco, relate to particularly a kind of expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays and preparation method thereof.
Background technology
After the traditional cigarette of circulation burning in the market, can produce gas phase and the mutually two-part aerosol of grain.Gas phase part accounts for 92% of whole flue gas quality, and grain mutually part accounts for 8%.Some compositions in this two parts aerosol pollute the environment, and in addition, the stub after smoking also exists the possibility of initiation fire.
Along with the step of international Tobacco Control campaign is more accelerated, national governments are especially further strict to the restriction of public place smoking to smoking, and formed gradually social consensus.Under increasingly strict Tobacco Control environment, new non-traditional tobacco product may be selected by Partial Tobacco consumer, and this variation tendency is day by day clear.Show according to statistical data in 2011, when worldwide Medicated cigarette volume of production and marketing declines to some extent, other types tobacco product presents rapid growth trend.It is estimated, within 2011, the world's non-traditional tobacco product market sale total value is about 60,000,000,000 dollars, and wherein smoke-free tobacco product is about 16,000,000,000 dollars, becomes one the rising forces on World tobacco market.Therefore, further research and develop Novel smokeless gas Nicotiana tabacum L. and seem particularly necessary.
Cough is a kind of protectiveness respiratory reflex action of human body.Can effectively remove the secretions in respiratory tract or enter the foreign body of air flue by coughre flex, but violent cough can cause respiratory tract hemorrhage, frequently cough not only can affect work and rest tempestuously for a long time, even can cause laryngalgia, hoarseness and breathing myalgia, now aspirate again traditional cigarette and can increase the weight of undoubtedly the phenomenon of coughing.The medicine that is used for the treatment of at present cough is divided into Western medicine and the large class of Chinese medicine two.Compared with Western medicine, Chinese medicine also has resolve phlegm effect in cough-relieving, and its property of medicine gentleness, side effect are little, although take effect not as Western medicine rapid, take stopgap measures and effect a permanent cure.
Summary of the invention
First technical problem that the present invention will solve is to provide a kind of expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays, comprises following material, counts: 5-30% tobacco extract by mass fraction; 0.14-4.2% Chinese herbal medicine extract; 1-10% flavouring essence for tobacco; All the other are auxiliary material; Wherein, described Chinese medicine extract is the extract of the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis; This spray can provide user to be equal to suck the gratification of traditional cigarette also to have second effect of expelling phlegm for arresting cough.
Second technical problem that the present invention will solve is to provide a kind of preparation method of expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays.
The present invention adopts following technical proposals:
A kind of expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays, comprises following material, counts: 5-30% tobacco extract by mass fraction; 0.14-4.2% Chinese herbal medicine extract; 1-10% flavouring essence for tobacco; All the other are auxiliary material; Wherein, described Chinese medicine extract is the extract of the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis.
Preferably, described Chinese herbal medicine extract is: 0.02-0.6% Radix Astragali extract, 0.02-0.6% Poria extract, 0.02-0.6% Exocarpium Citri Rubrum extract, 0.02-0.6% Flos Lonicerae extract, 0.02-0.6% Herba Houttuyniae extract, 0.02-0.6% Bulbus Fritillariae Cirrhosae extract and 0.02-0.6% Fructus Schisandrae Chinensis extrat.
Preferably, the pH value of described Nicotiana tabacum L. mouth sprays is 7～9; More preferably, the pH value of described Nicotiana tabacum L. mouth sprays is 9.Nicotine is one of main active in tobacco extract, and nicotine enters human circulation from buccal absorption and depends on the pH of saliva, blood plasma and the acid-base balance of nicotine.The acid-base balance of nicotine is that about pH is 7.8 at 37 ℃.The pH that supposes saliva is 6.8, and only approximately 10% nicotine will be uncharged alkali form.Therefore,, in order to promote nicotine to absorb take free alkali form (its as main by the form of mucosa absorption), must increase the pH of saliva.Be 9.0 o'clock at pH, the nicotine more than 90% will be the free alkali form easily absorbing.
Described tobacco extract is the Nicotiana tabacum L. effective active composition extracting from Nicotiana tabacum L., refer to contain in Nicotiana tabacum L. take alcohol, aldehyde, ketone, ester, hydro carbons, heterocyclic as main tobacco flavor material (benzyl alcohol, phytol, west uncle's three enediols, 3-methyl-2-butene aldehyde, benzaldehyde, solanone, Megastigmatrienone, dihydroactinidiolide, methyl hexadecanoate, ethyl palmitate, neophytadiene, pyridine etc.) and other bioactive substance, as alkaloid, Salanesol, protein, aminoacid and saccharide etc.
Preferably, described tobacco extract is one or more mixture in flue-cured tobacco extract, air-curing of tobacco leaves extract, solarization tobacco extract; Described air-curing of tobacco leaves is burley tobaccos, Maryland, wrapper cigarette; Described suncured tabacco is Turkish tobaccos, shines red cigarette, shines tobacco, Nicotiniana rustica; In Nicotiana tabacum L., the content of nicotine is 2.2～2.3%.
Preferably, described tobacco extract obtains by following steps: the 1) preparation of tobacco extract: by composite raw material, guarantee in raw tobacco that nicotine content is 2.2～2.3%, accurately take Nicotiana tabacum L. powder sample, add 75-80% alcohol reflux, solid-to-liquid ratio is 1:10～15, filters and get its filtrate after reflux, extract, 1～2h, at 55～65 ℃, water-bath concentrated filtrate, obtains tobacco extract; 2) setting different solvents system by countercurrent chromatography instrument separates tobacco extract; 3) determine fraction appearance time; 4) Fractional Collections effective active composition, obtains tobacco extract.
High-speed counter-current chromatograph is the instrument that can be used for the separation and acquisition of alkaloid compound in Nicotiana tabacum L., flavone compound, terpenoid, organic acid compound, lignin and coumarin kind compound, quinones.
Active component in Chinese herbal medicine extract, take Flos Lonicerae as example, the functional component such as the volatile oil (Palmic acid, aromatic alcohol, aromadendrene, linalool and geraniol) that exists in Flos Lonicerae, flavonoid (luteolin-7-O-α-D glucoside, luteolin-7-O-β-D-galactoside, Quercetin-3-O-β-D-Glucose glycosides, hyperin), organic acid (chlorogenic acid, isochlorogenic acid and caffeic acid), triterpenes (largeflower-like honeysuckle flower saponin first, largeflower-like honeysuckle flower saponin second, asperosaponin second) is exactly its active component of bringing into play many effects.
Described Chinese herbal medicine extract can directly be bought acquisition by market, also can extract voluntarily.While extraction voluntarily, can get indescribably by each Chinese medicine, finally mix, also can once extract the mixture of each Chinese medicine.
The equal integration of edible and medicinal herbs of Chinese herbal medicine relating in the present invention.
Preferably, described Chinese herbal medicine extract extracts according to following steps:
By each raw material of Chinese medicine mix homogeneously, in 70 ℃～75 ℃ pure water, flood, solid-to-liquid ratio is 1:10～15, and its filtrate is filtered and got to ultrasonic extraction after extracting 1～3h, filtering residue adds the water continuation supersound extraction 1～3h of 7～9 multiple doses to filter and get its filtrate again, merges twice filtrate; Filtrate is added and in Rotary Evaporators, is concentrated into 1/3 of filtrate volume～2/3 o'clock and stops concentrating, and cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.
That described Chinese herbal medicine is selected is dry, free from insect pests, without going rotten, the Chinese herbal medicine of free from extraneous odour, after pulverizer is pulverized, extract.
Those skilled in the art can select applicable flavouring essence for tobacco as required.Specifically, first by distill-GC/MS of head space, the fragrance matter of dissimilar Nicotiana tabacum L. is carried out qualitative and quantitative analysis or collects flue-cured tobacco total particulate matter in mainstream smoke with cambridge filter, adopt GC/MS to carry out qualitative and quantitative analysis to the fragrance matter of main flume, and then tentatively draft the kind of the flavouring essence for tobacco with Nicotiana tabacum L. note, adjust the adding proportion of different material, through cigarette, fragrant Shi Fanfu debates perfume (or spice), determines kind and the adding proportion of the flavouring essence for tobacco with Nicotiana tabacum L. note.Preferably; described flavouring essence for tobacco is dorinone, β-damascone, 2; 6; 6-trimethyl-2-cyclohexene-1; 4-diketone, 2-hydroxyl-3; 5; 5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, 5 methyl furfural, benzaldehyde, hyacinthin, benzyl alcohol, Palmic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, phenylacetic acid, dihydroactinidiolide, dimethyl succinate, indole, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine, 2; one or more mixture in 3,5-trimethylpyrazine.
Those skilled in the art can select applicable auxiliary material as required.Preferably, described auxiliary material comprise antiseptic, pH adjusting agent, sweeting agent, solvent.Amount ratio between various auxiliary material need not limit, and those skilled in the art can select according to actual needs.
More preferably, described antiseptic is benzoic acid and sodium benzoate, propanoic acid and sodium salt thereof or calcium salt, parabens and sodium salt thereof (Sodium Methyl Hydroxybenzoate, ethylparaben and sodium salt thereof), sorbic acid and potassium salt, potassium metabisulfite, sodium pyrosulfite, sodium sulfite, sodium sulfite or Hydros.The consumption of antiseptic uses the regulation of standard according to GB2760-2011 food additive.
Described pH adjusting agent is citric acid, sorbic acid, malic acid, sodium bicarbonate or sodium hydrogen phosphate.
Described sweeting agent is one or more synthetic sugar or natural sugar, is suitable as any type of saccharide of sweeting agent.
Described solvent is the mixture of pure water or pure water and edible glycerol.
Add edible glycerol and be for dissolve some not/be insoluble in the flavouring essence for tobacco of water, for example dorinone, β-damascone, 2,6,6-trimethyl-2-cyclohexene-Isosorbide-5-Nitrae-diketone, geranyl acetone, benzaldehyde, hyacinthin, Palmic acid, dihydroactinidiolide.The amount of edible glycerol meets dissolves flavouring essence for tobacco.
Spray of the present invention can adopt the various dosage specification packings of 20g, 50g, 100g etc.
A preparation method for expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays, comprises the following steps:
1) Radix Astragali extract, Poria extract, Exocarpium Citri Rubrum extract, Flos Lonicerae extract, Herba Houttuyniae extract, Bulbus Fritillariae Cirrhosae extract and Fructus Schisandrae Chinensis extrat are dissolved, obtain mixed solution A, for subsequent use;
2) flavouring essence for tobacco is dissolved, obtain mixed solution B, for subsequent use;
3) mixed solution A and mixed solution B are merged, add wherein tobacco extract, auxiliary material, stir, regulate pH to suitable pH value, then fill, in spraying bottle, is made finished product.
A preparation method for expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays, comprises the following steps:
1) by the extract mix homogeneously of the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis seven taste Chinese herbal medicine, add dissolved in purified water, obtain mixed solution A, for subsequent use;
2) by flavouring essence for tobacco, add proper amount of edible glycerol to dissolve, obtain mixed solution B, for subsequent use;
3) the mixed solution B of mixed solution A and exact mass is merged, add wherein tobacco extract, other auxiliary material, pure water is quantitative, stirs, and goods are adjusted to suitable pH value by pH adjusting agent, and then fill, in spraying bottle, is made finished product.
Beneficial effect of the present invention is as follows:
1, spray environmental protection of the present invention, smokeless, second effect also the gratification of traditional cigarette with expelling phlegm for arresting cough is provided except providing user to be equal to.
2, tobacco consumption person often uses that the present invention is this can not play a role in health care as the expelling phlegm for arresting cough mouth sprays of object take treatment disease, the person that the more important thing is tobacco consumption does not use these goods not only can not affect disease in cough in good time, also can assist and improve throat discomfort symptom; The report that there is not yet at present this type of expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays formula both at home and abroad, the present invention has broad application prospects.
3, preparation of the present invention can make user obtain being equal to the gratification of sucking traditional cigarette, can enjoy again expelling phlegm for arresting cough effect of Chinese herbal medicine active component, impact and the harm of second hand smoking to non-smokers and tobacco consumption person self that can also avoid traditional cigarette to burn on environment, its research and development and Study on manufacturing technology have important practical significance to accelerating Nicotiana tabacum L. scientific and technological progress, lifting cigarette brand value and tackling new Tobacco Control situation.
4, the present invention had both been applicable to male, had also been applicable to women, and user employing does not have medicine association but the means relevant to life just can be enjoyed expelling phlegm for arresting cough effect of medicinal herb components in formula.
5, add flavouring essence for tobacco can provide cigarette consumption person's olfactory sensation, sense of taste gratification.
6, compatibility of the present invention is reasonable, be easy to manufacture, the goods of spray-type are easy to carry, use health, spray goods of the present invention both can be used as the interim succedaneum of ban on opium-smoking and the opium trade place traditional cigarette, also can become a kind of desirable novel environment friendly functional type smoke-free tobacco product while cough in smoker's daily life.
The specific embodiment
In order to be illustrated more clearly in the present invention, below in conjunction with preferred embodiment, the present invention is described further.
The Radix Astragali, Poria: replenishing QI to invigorate the spleen, get rid of evils and go out.
Flos Lonicerae, Herba Houttuyniae: heat-clearing and toxic substances removing, tool is antibacterial, antiinflammatory action.
Exocarpium Citri Rubrum: regulating the flow of Qi and the middle Jiao, drying dampness to eliminate phlegm.
Bulbus Fritillariae Cirrhosae: the multiple alkaloid including and non-alkaloid part all have relieving cough and expelling phlegm, the effect of heat clearing away eliminating stagnation.
Fructus Schisandrae Chinensis: the nourishing kidney of astringing the lung, arresting sweating promotes the production of body fluid.
Embodiment 1
Preparation 20g spray goods:
(1) by adding 10g dissolved in purified water after the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis seven taste Chinese herbal medicine extract mix homogeneously, obtain mixed solution A, for subsequent use;
(2) by the flavouring essence for tobacco mix homogeneously taking in ratio in upper table, add proper amount of edible glycerol to dissolve, obtain mixed solution B, (when use, taking as requested again exact mass) for subsequent use;
(3) the mixed solution B of mixed solution A and exact mass is merged, add wherein tobacco extract, Nepal's ethyl ester, sucrose, pure water quantitatively arrives 20g, stir, goods are adjusted to suitable pH value by pH adjusting agent, then fill, in spraying bottle, is made finished product.
Result of use is evaluated: organize the mouth sprays goods of three Nicotiana tabacum L. evaluation and analysis librarian uses containing 30% tobacco extract, experimental result shows, in the time that the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and can on average continue 66min without smoking cigarette desire.
Embodiment 2
Preparation 50g spray goods:
(1) by adding 30g dissolved in purified water after the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis seven taste Chinese herbal medicine extract mix homogeneously, obtain mixed solution A, for subsequent use;
(2) by the flavouring essence for tobacco mix homogeneously taking in ratio in upper table, add proper amount of edible glycerol to dissolve, obtain mixed solution B, (when use, taking as requested again exact mass) for subsequent use;
(3) the mixed solution B of mixed solution A and exact mass is merged, add wherein tobacco extract, sorbic acid, sucrose, pure water quantitatively arrives 50g, stir, goods are adjusted to suitable pH value by pH adjusting agent, then fill, in spraying bottle, is made finished product.
Result of use is evaluated: organize the mouth sprays goods of three Nicotiana tabacum L. evaluation and analysis librarian uses containing 25% tobacco extract, experimental result shows, in the time that the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and can on average continue 57min without smoking cigarette desire.
Embodiment 3
Preparation 100g spray goods:
(1) by adding 65g dissolved in purified water after the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis seven taste Chinese herbal medicine extract mix homogeneously, obtain mixed solution A, for subsequent use;
(2) by the flavouring essence for tobacco mix homogeneously taking in ratio in upper table, add proper amount of edible glycerol to dissolve, obtain mixed solution B, (when use, taking as requested again exact mass) for subsequent use;
(3) the mixed solution B of mixed solution A and exact mass is merged, add wherein tobacco extract, Nepal's ethyl ester, sucrose, pure water quantitatively arrives 100g, stir, goods are adjusted to suitable pH value by pH adjusting agent, then fill, in spraying bottle, is made finished product.
Result of use is evaluated: organize the mouth sprays goods of three Nicotiana tabacum L. evaluation and analysis librarian uses containing 20% tobacco extract, experimental result shows, in the time that the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and can on average continue 48min without smoking cigarette desire.
Embodiment 4
A kind of expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays, comprises following material, counts: 5% tobacco extract by mass fraction; 0.14% Chinese herbal medicine extract; 1% flavouring essence for tobacco; All the other are auxiliary material; Wherein, described Chinese medicine extract is the extract of the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis.
Described tobacco extract is the extract of flue-cured tobacco, obtain by following steps: the 1) preparation of tobacco extract: in flue-cured tobacco, nicotine content is 2.2～2.3%, accurately take Nicotiana tabacum L. powder sample, add 75% alcohol reflux, solid-to-liquid ratio is 1:10, after reflux, extract, 1h, filter and get its filtrate, water-bath concentrated filtrate at 55 ℃, obtains tobacco extract; 2) setting different solvents system by countercurrent chromatography instrument separates tobacco extract; 3) determine fraction appearance time; 4) Fractional Collections effective active composition, obtains tobacco extract.
Described Chinese herbal medicine extract extracts according to following steps: by each raw material of Chinese medicine mix homogeneously, in 70 ℃ of pure water, flood, solid-to-liquid ratio is 1:10, its filtrate is filtered and got to ultrasonic extraction after extracting 1h, filtering residue adds the water continuation supersound extraction 1h of 7 multiple doses to filter and get its filtrate again, merges twice filtrate; By filtrate add in Rotary Evaporators, be concentrated into filtrate volume within 1/3 o'clock, stop concentrating, cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.
Described flavouring essence for tobacco is dorinone, β-damascone, 2,6,6-trimethyl-2-cyclohexene-1,4-diketone, 2-hydroxyl-3, the mixture (mass ratio 1:2.5:0.5:2:2:3:1.5:2) of 5,5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, 5 methyl furfural.
Described auxiliary material comprise preservative sodium benzoate, pH adjusting agent citric acid, sweeting agent, solvent (mixture of water and edible glycerol).
Embodiment 5
A kind of expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays, comprises following material, counts: 5% tobacco extract by mass fraction; 0.6% Radix Astragali extract, 0.6% Poria extract, 0.6% Exocarpium Citri Rubrum extract, 0.6% Flos Lonicerae extract, 0.6% Herba Houttuyniae extract, 0.6% Bulbus Fritillariae Cirrhosae extract, 0.6% Fructus Schisandrae Chinensis extrat; 3% flavouring essence for tobacco; All the other are auxiliary material.The pH value of described Nicotiana tabacum L. mouth sprays is 7.
Described tobacco extract is the extract of burley tobaccos, Maryland and wrapper cigarette, obtain by following steps: the 1) preparation of tobacco extract: by composite raw material, guarantee that nicotine content in tobacco leaf is 2.2～2.3%, accurately take Nicotiana tabacum L. powder sample, add 75-80% alcohol reflux, solid-to-liquid ratio is 1:10～15, filters and get its filtrate after reflux, extract, 1～2h, at 55～65 ℃, water-bath concentrated filtrate, obtains tobacco extract; 2) setting different solvents system by countercurrent chromatography instrument separates tobacco extract; 3) determine fraction appearance time; 4) Fractional Collections effective active composition, obtains tobacco extract.
Described Chinese herbal medicine extract extracts according to following steps: by each raw material of Chinese medicine mix homogeneously, in 75 ℃ of pure water, flood, solid-to-liquid ratio is 1:15, its filtrate is filtered and got to ultrasonic extraction after extracting 3h, filtering residue adds the water continuation supersound extraction 3h of 9 multiple doses to filter and get its filtrate again, merges twice filtrate; By filtrate add in Rotary Evaporators, be concentrated into filtrate volume within 2/3 o'clock, stop concentrating, cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.
Described flavouring essence for tobacco is the mixture (mass ratio 1:2.5:0.5:2:2:3:1.5:2:1) of benzaldehyde, hyacinthin, benzyl alcohol, Palmic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, phenylacetic acid, dihydroactinidiolide.
Described auxiliary material comprise antiseptic propanoic acid, pH adjusting agent malic acid, sweeting agent, solvent (mixture of water and edible glycerol).
Embodiment 6
A kind of expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays, comprises following material, counts: 30% tobacco extract by mass fraction; 0.02% Radix Astragali extract, 0.02% Poria extract, 0.02% Exocarpium Citri Rubrum extract, 0.2% Flos Lonicerae extract, 0.2% Herba Houttuyniae extract, 0.2% Bulbus Fritillariae Cirrhosae extract, 0.3% Fructus Schisandrae Chinensis extrat; 10% flavouring essence for tobacco; All the other are auxiliary material.The pH value of described Nicotiana tabacum L. mouth sprays is 8.
Described tobacco extract is Turkish tobaccos, shine red cigarette, shine the extract of tobacco and Nicotiniana rustica, obtain by following steps: the 1) preparation of tobacco extract: by composite raw material, guarantee that nicotine content in tobacco leaf is 2.2～2.3%, accurately take Nicotiana tabacum L. powder sample, add 78% alcohol reflux, solid-to-liquid ratio is 1:12, filters and get its filtrate after reflux, extract, 1.5h, at 60 ℃, water-bath concentrated filtrate, obtains tobacco extract; 2) setting different solvents system by countercurrent chromatography instrument separates tobacco extract; 3) determine fraction appearance time; 4) Fractional Collections effective active composition, obtains tobacco extract.
Described Chinese herbal medicine extract extracts according to following steps: by each raw material of Chinese medicine mix homogeneously, in 72 ℃ of pure water, flood, solid-to-liquid ratio is 1:12, its filtrate is filtered and got to ultrasonic extraction after extracting 2h, filtering residue adds the water continuation supersound extraction 2h of 8 multiple doses to filter and get its filtrate again, merges twice filtrate; By filtrate add in Rotary Evaporators, be concentrated into filtrate volume within 1/2 o'clock, stop concentrating, cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.
Described flavouring essence for tobacco is the mixture (mass ratio 2.5:0.5:2:2:3:1.5:1) in dimethyl succinate, indole, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine, 2，3，5-trimethylpyrazine.
Described auxiliary material comprise antiseptic sorbic acid, pH adjusting agent sodium bicarbonate, sweeting agent, solvent (mixture of water and edible glycerol).
Embodiment 7
With embodiment 6, difference is: antiseptic is that potassium metabisulfite, pH adjusting agent are sorbic acid.
Embodiment 8
With embodiment 6, difference is: antiseptic is that sodium pyrosulfite, pH adjusting agent are sodium hydrogen phosphate.
Embodiment 9
With embodiment 6, difference is: antiseptic is sodium sulfite.
Embodiment 10
With embodiment 6, difference is: antiseptic is sodium sulfite.
Embodiment 11
With embodiment 6, difference is: antiseptic is Hydros.
Embodiment 12
With embodiment 6, difference is: antiseptic is p-Hydroxybenzoate.
Embodiment 13
With embodiment 6, difference is: antiseptic is ethylparaben.
Embodiment 14
With embodiment 6, difference is: antiseptic is nipagin A sodium salt.
Obviously; the above embodiment of the present invention is only for example of the present invention is clearly described; and be not the restriction to embodiments of the present invention; for those of ordinary skill in the field; can also make other changes in different forms on the basis of the above description; here cannot give all embodiments exhaustively, everyly belong to apparent variation or the still row in protection scope of the present invention of variation that technical scheme of the present invention extends out.
Claims (9)
1. an expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays, is characterized in that, comprises following material, counts by mass fraction: 5-30% tobacco extract; 0.14-4.2% Chinese herbal medicine extract; 1-10% flavouring essence for tobacco; All the other are auxiliary material; Wherein, described Chinese medicine extract is the extract of the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis.
2. expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays according to claim 1, it is characterized in that, described Chinese herbal medicine extract is: 0.02-0.6% Radix Astragali extract, 0.02-0.6% Poria extract, 0.02-0.6% Exocarpium Citri Rubrum extract, 0.02-0.6% Flos Lonicerae extract, 0.02-0.6% Herba Houttuyniae extract, 0.02-0.6% Bulbus Fritillariae Cirrhosae extract and 0.02-0.6% Fructus Schisandrae Chinensis extrat.
3. expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays according to claim 1, is characterized in that, the pH value of described Nicotiana tabacum L. mouth sprays is 7～9; More preferably, the pH value of described Nicotiana tabacum L. mouth sprays is 9.
4. expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays according to claim 1, is characterized in that, described tobacco extract is one or more mixture in flue-cured tobacco extract, air-curing of tobacco leaves extract, solarization tobacco extract; Described air-curing of tobacco leaves is burley tobaccos, Maryland, wrapper cigarette; Described suncured tabacco is Turkish tobaccos, shines red cigarette, shines tobacco, Nicotiniana rustica; Wherein, in Nicotiana tabacum L., the content of nicotine is 2.2～2.3%.
5. expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays according to claim 1, it is characterized in that, described tobacco extract obtains by following steps: the 1) preparation of tobacco extract: by composite raw material, guarantee that in raw tobacco, nicotine content, 2.2～2.3%, accurately takes Nicotiana tabacum L. powder sample, add 75-80% alcohol reflux, solid-to-liquid ratio is 1:10～15, after reflux, extract, 1～2h, filter and get its filtrate, water-bath concentrated filtrate at 55～65 ℃, obtains tobacco extract; 2) setting different solvents system by countercurrent chromatography instrument separates tobacco extract; 3) determine fraction appearance time; 4) Fractional Collections effective active composition, obtains tobacco extract.
6. expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays according to claim 1, it is characterized in that, described flavouring essence for tobacco is dorinone, β-damascone, 2, 6, 6-trimethyl-2-cyclohexene-1, 4-diketone, 2-hydroxyl-3, 5, 5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, bran aldehyde, 5 methyl furfural, benzaldehyde, hyacinthin, benzyl alcohol, Palmic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, phenylacetic acid, dihydroactinidiolide, dimethyl succinate, indole, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine, 2, 3, one or more mixture in 5-trimethylpyrazine.
7. expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays according to claim 1, is characterized in that, described auxiliary material comprise antiseptic, pH adjusting agent, sweeting agent, solvent;
Preferably, described antiseptic is benzoic acid and sodium benzoate, propanoic acid and sodium salt thereof or calcium salt, parabens and sodium salt thereof, sorbic acid and potassium salt thereof, potassium metabisulfite, sodium pyrosulfite, sodium sulfite, sodium sulfite or Hydros; More preferably, described parabens and sodium salt thereof are parabens and sodium salt, ethylparaben and sodium salt thereof;
Described pH adjusting agent is citric acid, sorbic acid, malic acid, sodium bicarbonate or sodium hydrogen phosphate;
Described sweeting agent is one or more synthetic sugar or natural sugar;
Described solvent is the mixture of pure water or pure water and edible glycerol.
8. the preparation method of the expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays as described in as arbitrary in claim 1～7, is characterized in that, comprises the following steps:
1) Radix Astragali extract, Poria extract, Exocarpium Citri Rubrum extract, Flos Lonicerae extract, Herba Houttuyniae extract, Bulbus Fritillariae Cirrhosae extract and Fructus Schisandrae Chinensis extrat are dissolved, obtain mixed solution A, for subsequent use;
2) flavouring essence for tobacco is added edible glycerol dissolve, obtain mixed solution B, for subsequent use;
3) mixed solution A and mixed solution B are merged, add wherein tobacco extract, auxiliary material, stir, regulate pH to suitable pH value, then fill, in spraying bottle, is made finished product.
9. the preparation method of expelling phlegm for arresting cough type Nicotiana tabacum L. mouth sprays according to claim 8, is characterized in that, comprises the following steps:
1) by the extract mix homogeneously of the Radix Astragali, Poria, Exocarpium Citri Rubrum, Flos Lonicerae, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae and Fructus Schisandrae Chinensis seven taste Chinese herbal medicine, add dissolved in purified water, obtain mixed solution A, for subsequent use;
2) flavouring essence for tobacco is added edible glycerol dissolve, obtain mixed solution B, for subsequent use;
3) the mixed solution B of mixed solution A and exact mass is merged, add wherein tobacco extract, other auxiliary material, pure water is quantitative, stirs, and goods are adjusted to suitable pH value by pH adjusting agent, and then fill, in spraying bottle, is made finished product.
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