CN101380137B - Yew low-evil cigarette - Google Patents
Yew low-evil cigarette Download PDFInfo
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- CN101380137B CN101380137B CN2008102167140A CN200810216714A CN101380137B CN 101380137 B CN101380137 B CN 101380137B CN 2008102167140 A CN2008102167140 A CN 2008102167140A CN 200810216714 A CN200810216714 A CN 200810216714A CN 101380137 B CN101380137 B CN 101380137B
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Abstract
The invention discloses a less harmful yew cigarette, and aims at solving the technical problem of reducing the harm of the cigarette to smokers and improving the flavor of the cigarette. The less harmful yew cigarette has tobacco shred; according to the weight percentage of the tobacco shred, the tobacco shred contains 0.05-70% of yew volatile oil, or 0.001-70% of yew extracts, or the two. Compared with the prior art, the tobacco shred of the less harmful yew cigarette contains the yew volatile oil and the yew extracts which are volatile, have moderate or lower polarity and strong lipid solubility, can enter human body along with the main smoke stream, and can be absorbed by the human body through blood circulation, thus exerting the anticancer pharmacological actions thereof. The cigarette has delicately scented and mellow cigarette smoke, can reduce the cigarette harm, and has certain prophylactic and therapeutic effects on a plurality of cancer diseases by long-term inhalation.
Description
Technical field
The present invention relates to a kind of cigarette, particularly a kind of low-harmful cigarette.
Background technology
Harmfulness of smoking health has been a undisputable fact, great mass of data shows, in the smog of cigarette, contain multiple noxious material, can cause increasing of disease incidences such as human body cancer, arterial thrombotic disease, immunologic function reduction, breathing problem, hypogona dism.For long-term smoker, smoking cessation is often very difficult, so relevant researcher is being devoted to improve the prescription of tobacco always, reduces the wherein content of tar.The researcher of China then makes full use of the treasure-house of traditional traditional Chinese medicine and pharmacy, in pipe tobacco, add Chinese herbal medicine, be intended to make the smoker in smoking process, can suck composition useful in the Chinese herbal medicine, to weaken or to reduce the harm of cigarette, developed a series of health cigarette up to now, as the disclosed gynostemma laxum medicinal cigarette of Chinese patent application 91102882.X, 88103508.4 disclosed cigarette from Chinese muswort leaf, 03139013.7 disclosed tea cigarette, in tobacco leaf, add bluish dogbane in addition, Radix Codonopsis, peppermint, cortex acanthopanacis, long white ginseng, the mixed type medical cigarette that tendril-leaved fritillary bulb etc. are made, these low evil cigarette utilizations are the characteristic of contained Chinese medicine separately, the smoker is played different low evil effects, have anticancer as the blue medicinal health-care smoking set of strand glue, antifatigue, anti-ageing, effects such as treatment tracheitis.However, the low-harm cigarette of prior art still can not satisfy the needs of the generation of the various diseases that may cause when the prevention smoker smokes, and the cigarette fragrance that adds behind the Chinese herbal medicine decreases.
Summary of the invention
The purpose of this invention is to provide a kind of Yew low-evil cigarette, the technical problem that solve is to reduce the harm of cigarette to the smoker, increases the fragrance of cigarette.
The present invention is by the following technical solutions: a kind of Yew low-evil cigarette, have pipe tobacco, and contain more than one of Chinese yew extract of the Chinese yew volatile oil that accounts for pipe tobacco weight ratio 0.05～70% and 0.001～70% in the described pipe tobacco.
Chinese yew extract of the present invention is taxol compound and/or taxane total diterpene compound.
Taxol compound structural formula of the present invention is:
Taxane total diterpene structural formula of compound of the present invention is:
Chinese yew volatile oil of the present invention is the volatile oil of its branches and leaves and/or skin.
Chinese yew extract of the present invention is the extract of its branches and leaves, skin, root, stem.
The present invention compared with prior art, contain Chinese yew volatile oil and Chinese yew extract in the pipe tobacco, kind of volatile oil component surplus containing 60 in the Chinese yew, taxanes diterpene compound surplus the strong anti-cancer active matter taxol and 400 of mechanism of action uniqueness with similar structures and activity, polarity is medium or on the low side, fat-soluble strong, volatile, in smoking process, can enter human body with main flume, be absorbed by the body by blood circulation, thereby bring into play its anticancer pharmacological action, smoke alcohol and delicate fragrance can reduce the harm of cigarette, and long-term the suction all has certain prevention and therapeutic action to multiple Cancerous disease.
The specific embodiment
The present invention is described in detail below in conjunction with embodiment.Yew low-evil cigarette of the present invention, utilize Chinese yew to contain kind of volatile oil component surplus in the of 60 based on essence and flavoring agent, anti-cancer medicine paclitaxel, be represented compound structure of formula (1) and the activity that has, the taxanes diterpene compound similar to taxol, suc as formula one or several compound in (2), has prevention human body cancer, arterial thrombotic disease, immunologic function reduces, breathing problem, the effect of useful human body such as hypogona dism, and contained active ingredient to have polarity medium or on the low side, fat-soluble strong, volatile characteristics, Chinese yew is added in the cigarette, reduce the harm of cigarette, increase the fragrance of cigarette, make multiple cancer, disease all has the Yew low-evil cigarette of certain prevention and therapeutic action, make the smoker in smoking, effective medicinal ingredient is of value to health in the Chinese yew thereby can suck.
The present invention adds Chinese yew in the pipe tobacco of cigarette, described Chinese yew comprises the Chinese yew different parts, as the volatile oil of branches and leaves, skin, perhaps contain in the extract of Chinese yew different parts anti-cancer medicine paclitaxel (
/ Paclitaxel) be formula (1) compound, the taxanes diterpene compound (Taxanes/Taxoids) that perhaps contains active anticancer in the extract of Chinese yew different parts, one or several compound in the formula (2), the perhaps arbitrary composition between their threes.Detailed process is that the volatile oil of Chinese yew is sprayed on the pipe tobacco, or be that the Chinese yew extract of formula (1) compound is sprayed on the pipe tobacco containing anti-cancer medicine paclitaxel, or containing taxanes diterpene compound with active anticancer, the Chinese yew extract of one or several compound in the formula (2) is sprayed on the pipe tobacco, promptly makes with conventional cigarette process or tobacco slice technology then.
Chinese yew (Taxus) also be Japanese yew, and the whole world has 11 kinds approximately, and there be 4 kind of 1 mutation in China.Chinese Ancient Books " book on Chinese herbal medicine pushes away newly " record " Japanese yew can be used as medicine, and diuresis, stimulates the menstrual flow, and controls kidney trouble, diabetes ", and spread among the people always.Gas-chromatography (GC) and gas-chromatography and mass spectrometry (GC-MS) studies show that, kind of volatile oil component surplus being rich in 60 in the Taxus leaf, wherein main component is: trans-2-octen-1-ol (～14%), pentacosane (～8%), epoxy carypohyllene (～7%), n-octyl alcohol (～6%), n-caproic acid (～5%) and anti--3-hexenol (～4%) etc.Trans-2-octen-1-ol is the food spices (Ministry of Public Health bulletin 2005 year No. 3) of the Ministry of Public Health according to the approval of " Food Hygiene Law of the People's Republic of China " and " food additives administration of health way " regulation.Pentacosane is one of main component of plurality of Chinese (as: cattail pollen, mongolian oak leaf etc.).The epoxy carypohyllene also is a kind of important fragrance product, can make cigarette fumet (" terpene flavor chemistry ", Huang Zhixi, Wang Huichen work, ISBN7501922756, China Light Industry Press, 346～350 pages).N-octyl alcohol can be used for making essence and cosmetics.N-caproic acid is one of fragrance component in the liquor, can be used for preparing all kinds of flavoring essences.Instead-the 3-hexenol has good fragrant, can be used for making perfume and cosmetics.The Chinese yew different parts, novelty, evident in efficacy, famous natural antitumor diterpene-kind compound taxol that mechanism of action is unique as containing complex structure in branches and leaves, skin, the root (
/ Paclitaxel).The taxol initial stage is approved for treatment recurrent and intractable oophoroma, breast cancer, non-small cell lung cancer etc.Because the exploitation of new role, cooperate the research and development success of novel form, compound medicine etc., the taxanes medicine extensively is applied to carcinoma of urinary bladder, cervical carcinoma, carcinoma of endometrium, cancer of the esophagus, Head and Neck cancer, prostate cancer, black cancer, cancer of the stomach, liver cancer, osteosarcoma, lung squamous cancer, adenocarcinoma of lung, embryonal carcinoma of testis, pernicious thymic carcinoma, tongue cancer, bronchiolar carcinoma, lymph cancer, germinocarcinoma, pernicious spongiocyte cancer, nasopharyngeal carcinoma etc. at a clinical line now.The taxanes medicine has become genuine broad-spectrum anti-cancer drug, is present best in the world cancer therapy drug after adriamycin and Platinol cisplatin, be so far the international market be in great demand most, the most popular new type anticancer medicine, have high value of exploiting and utilizing.Except that cancer, the therapeutic domain of taxanes medicine also constantly enlarges, as rheumatism, AE, diabetes, psoriasis, cardiovascular disease etc.Low dose of taxol injection is used to the rheumatoid disease treatment, has entered clinical testing, and its pharmacological action is to improve immune function of human body.The research of producing Remedies for diabetes with Chinese yew has entered later stage.Many anti-inflammatory of the Chinese yew that folklore, health care, remove that pin is smelly, profit skin or the like purposes, also constantly be verified and use.In addition, discover that Chinese yew also contains abundant structures and the active taxanes diterpene compound similar to taxol except containing taxol.Up to the present, never be divided into a taxanes diterpene compound surplus identified 400 in the different parts of Chinese yew genus plants of the same race.Also have, experiment shows that the actual nontoxic level of Taxus is not seen genetoxic, and taking for a long time is safe (Song Xueying, Wang Jianxin, Chinese Hospitals pharmaceutical journal, 2007,27 (12): 1789-1791).
The Chinese yew different parts, volatile oil or extract as branches and leaves, skin add in the pipe tobacco, its burning velocity of starting to exchange fire is moderate, utilize cigarette in the suction combustion process, to have the more and more lower thermograde of temperature between from the combustion head to the filter tip like this, volatile active ingredients such as volatile oil in the Chinese yew, taxol, taxanes diterpene compound were not just volatilized with main flume before also being destroyed by high temperature together and be inhaled into human body, thereby reach health-care effect.Yew low-evil cigarette smoke alcohol of the present invention and delicate fragrance, not only do not influence original mouthfeel of cigarette, and sweet sensation arranged after the suction, antitumor, as to treat kidney trouble, diabetes, ephritis edema, difficult urination, gonorrhoea, irregular menstruation, postpartum blood stasis, dysmenorrhoea effect is arranged, various Cancerous diseases especially oophoroma, breast cancer, lung cancer, colorectal cancer, melanoma, Head and Neck cancer, lymthoma, brain tumor are had certain prevention and therapeutic action.
In order to confirm the antitumaous effect of Chinese yew extract, choose C
57The BL/6 mouse is duplicated the Lewis mice model of lung cancer, respectively with Chinese yew extract 5g/kg, 10g/kg, 20g/kg dosage group gastric infusion, observes the inhibitory action that it was grown to the model mice transplanted tumor after 10 days.Found that, compare with control group that Chinese yew extract dosage group has the obvious suppression effect to Lewis lung cancer, its inhibiting rate is respectively 26%, 36%, 45%; Choose the ICR mouse, duplicate the HepA liver cancer mouse model, press such scheme (same dose and approach) administration.Found that, compare with control group that Chinese yew extract dosage group has the obvious suppression effect to HepA liver cancer, its inhibiting rate is respectively 23%, 32%, 42%; Choose the ICR mouse, duplicate S
180The sarcoma mouse model is pressed such scheme (same dose and approach) administration.Found that, compare that Chinese yew extract dosage group is to S with control group
180Sarcoma has the obvious suppression effect, and its inhibiting rate is respectively 25%, 35%, 61%.
In order to confirm that thereby the Chinese yew active ingredient in the pipe tobacco can enter human body with the flue gas volatilization, employing gas-chromatography and mass spectrometry are that the analytical method of GC-MS detects flue gas, the result shows: the 88%-92% that has added cigarette volatile oil in burning of Chinese yew volatile oil can be dispersed in the flue gas, the active ingredient that has added cigarette 75%-80% in burning of Chinese yew extract can be dispersed in the flue gas, and fragrance is plentiful pure and mild.
Embodiment 1: get the Chinese yew different parts, as branches and leaves, skin fresh sample, add the water distillation, make Chinese yew volatile oil, 0.5% weight percentage by pipe tobacco weight evenly is sprayed on the common pipe tobacco then, dries, and promptly makes with conventional cigarette process or tobacco slice technology again.
Embodiment 2: get the Chinese yew different parts, as branches and leaves, skin, shine dry grinding, 95% alcohol reflux or cold soaking extract, filtrate decompression is condensed into flowing soaking paste, with petroleum ether degreasing and pigment, uses chloroform extraction then 3～4 times, the combining extraction liquid decompression and solvent recovery gets Chinese yew extract or taxane total diterpene to doing.This total diterpene with the dissolving of 95% ethanol, evenly is sprayed on the common pipe tobacco by taxane total diterpene 0.3% weight percentage, minimumly can be 0.001%, dry, promptly make with conventional cigarette process or tobacco slice technology again.
Embodiment 3: get the Chinese yew different parts, as branches and leaves, skin, shine dry grinding, 95% alcohol reflux or cold soaking extract, and filtrate decompression is condensed into flowing soaking paste, with petroleum ether degreasing and pigment, use chloroform extraction then 3～4 times, the combining extraction liquid decompression and solvent recovery gets the taxane total diterpene to doing.The active site that further repeatedly, must contain taxol 80%～90% with purification by silica gel column chromatography.This active site with the dissolving of 95% ethanol, evenly is sprayed on the common pipe tobacco by 0.05% weight percentage, dries, promptly make with conventional cigarette process or tobacco slice technology again.
Embodiment 4: Chinese yew volatile oil that method described in embodiment 1 and the embodiment 2 is obtained and Chinese yew extract (taxane total diterpene) respectively, evenly be sprayed on the common pipe tobacco, dry, promptly make Chinese yew medicinal health-care cigarette with conventional cigarette process or tobacco slice technology again.Total addition of Chinese yew volatile oil and Chinese yew extract (taxane total diterpene) is 1%, and wherein Chinese yew volatile oil and Chinese yew extract (taxane total diterpene) respectively account for half.
The present invention has no particular limits the amount that Chinese yew volatile oil and Chinese yew extract join in the pipe tobacco, and the mouthfeel when mainly looking smoking decides, and its addition weight ratio reaches as high as 70%.And Chinese yew volatile oil and Chinese yew extract can adopt the method for any known to prepare.
Claims (5)
1. a Yew low-evil cigarette has pipe tobacco, it is characterized in that: more than one of Chinese yew extract that contain the Chinese yew volatile oil that accounts for pipe tobacco weight ratio 0.05～70% and 0.001～70% in the described pipe tobacco;
Described Chinese yew extract is taxol compound and/or taxane total diterpene compound;
Described taxol compound structural formula is:
Described taxane total diterpene structural formula of compound is:
Described Chinese yew volatile oil is the volatile oil of its branches and leaves and/or skin;
Described Chinese yew extract is the extract of its branches and leaves, skin, root, stem.
2. Yew low-evil cigarette according to claim 1, it is characterized in that: described Yew low-evil cigarette adopts following steps to prepare: branches and leaves, the skin fresh sample of getting Chinese yew, add the water distillation, make Chinese yew volatile oil, 0.5% weight percentage by pipe tobacco weight evenly is sprayed on the common pipe tobacco then, dry, promptly make with conventional cigarette process or tobacco slice technology again.
3. Yew low-evil cigarette according to claim 1, it is characterized in that: described Yew low-evil cigarette adopts following steps to prepare: the branches and leaves of getting Chinese yew, skin, shine dry grinding, 95% alcohol reflux or cold soaking extract, filtrate decompression is condensed into flowing soaking paste, with petroleum ether degreasing and pigment, use chloroform extraction then 3～4 times, the combining extraction liquid decompression and solvent recovery is to doing, Chinese yew extract or taxane total diterpene, this total diterpene is dissolved with 95% ethanol, evenly be sprayed on the common pipe tobacco by taxane total diterpene 0.3% weight percentage, dry, promptly make with conventional cigarette process or tobacco slice technology again.
4. Yew low-evil cigarette according to claim 1, it is characterized in that: described Yew low-evil cigarette adopts following steps to prepare: the branches and leaves of getting Chinese yew, skin, shine dry grinding, 95% alcohol reflux or cold soaking extract, filtrate decompression is condensed into flowing soaking paste, with petroleum ether degreasing and pigment, use chloroform extraction then 3～4 times, the combining extraction liquid decompression and solvent recovery is to doing, get the taxane total diterpene, further with purification by silica gel column chromatography, the active site that must contain taxol 80%～90% with the dissolving of 95% ethanol, evenly is sprayed at this active site on the common pipe tobacco by 0.05% weight percentage, dry, promptly make with conventional cigarette process or tobacco slice technology again.
5. Yew low-evil cigarette according to claim 1 is characterized in that: described Yew low-evil cigarette adopts following steps to prepare: get branches and leaves, the skin fresh sample of Chinese yew, add the water distillation, make Chinese yew volatile oil; Get branches and leaves, the skin of Chinese yew, shine dry grinding, 95% alcohol reflux or cold soaking extract, filtrate decompression is condensed into flowing soaking paste, with petroleum ether degreasing and pigment, uses chloroform extraction then 3～4 times, the combining extraction liquid decompression and solvent recovery gets Chinese yew extract or taxane total diterpene to doing; With Chinese yew volatile oil and Chinese yew extract or taxane total diterpene, evenly be sprayed on the common pipe tobacco respectively, dry, promptly make Chinese yew medicinal health-care cigarette with conventional cigarette process or tobacco slice technology again; Total addition of Chinese yew volatile oil and Chinese yew extract or taxane total diterpene is 1%, and wherein Chinese yew volatile oil and Chinese yew extract or taxane total diterpene respectively account for half.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102167140A CN101380137B (en) | 2008-10-14 | 2008-10-14 | Yew low-evil cigarette |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102167140A CN101380137B (en) | 2008-10-14 | 2008-10-14 | Yew low-evil cigarette |
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| Publication Number | Publication Date |
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| CN101380137A CN101380137A (en) | 2009-03-11 |
| CN101380137B true CN101380137B (en) | 2011-06-22 |
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| CN2008102167140A Active CN101380137B (en) | 2008-10-14 | 2008-10-14 | Yew low-evil cigarette |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106723318A (en) * | 2016-11-30 | 2017-05-31 | 赵凯华 | A kind of cigarette companion and preparation method thereof |
| CN107467719A (en) * | 2017-08-29 | 2017-12-15 | 贵州普定印象朵贝农业开发有限公司 | A kind of Chinese yew electronic cigarette |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1428107A (en) * | 2001-12-24 | 2003-07-09 | 张敬远 | Medicated health-care cigarette |
| CN101061887A (en) * | 2006-04-26 | 2007-10-31 | 曹宁 | Cancer-proof cigarette made by paclitaxel and the method of producing the same |
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- 2008-10-14 CN CN2008102167140A patent/CN101380137B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1428107A (en) * | 2001-12-24 | 2003-07-09 | 张敬远 | Medicated health-care cigarette |
| CN101061887A (en) * | 2006-04-26 | 2007-10-31 | 曹宁 | Cancer-proof cigarette made by paclitaxel and the method of producing the same |
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| CN101380137A (en) | 2009-03-11 |
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Effective date of registration: 20190701 Address after: 518102 11th Floor, Building A, Dabaihui High-tech Industrial Park, Shenzhen Yantian District, Guangdong Province Patentee after: Shenzhen Dabaihui Technology Co., Ltd. Address before: 518102 Shenyan Road 2002, Yantian District, Shenzhen City, Guangdong Province Patentee before: Shennong Yanke Technology Co., Ltd., Guangdong |