CN101264277B - Compound essential oil for controlling smoke and giving up smoking - Google Patents
Compound essential oil for controlling smoke and giving up smoking Download PDFInfo
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- CN101264277B CN101264277B CN200810015330A CN200810015330A CN101264277B CN 101264277 B CN101264277 B CN 101264277B CN 200810015330 A CN200810015330 A CN 200810015330A CN 200810015330 A CN200810015330 A CN 200810015330A CN 101264277 B CN101264277 B CN 101264277B
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Abstract
The invention relates to a smoking control and cessation compound essential oil, which is a compound natural aromatic essential oil made of more than thirty two kind of simple recipe essential oils, olive oil and Jojoba oil; the simple recipe essential oils are respectively extracted from snow lotus, sanders wood, chamomile, France bodhi, myrrh, lavender, cassia bark, pharmaceutical hops, Egypt jasmine, olibanum, lemon, agalloch eaglewood, heartleaf houttuynia herb, zanthoxylum husk, flower of sweet osmanthus, menthol, borneol, green tea, common aucklandia root, sweet orange, rosmarinus officinalis, Roman chamonile, cascarilla, honeysuckle flower, herb of wrinkled gianthyssop, artificial muskiness, nutgrass galingale rhizome, Italy orange blossom, St. John's grass, nutmeg, clove, angelica sinensis and propolis, and 33 kinds of components; the invention has the smoking control and cessation effect, and the general efficiency is higher than 96.7%. The smoking control and cessation compound essential oil has the advantages of significant effect, no malignant stimulation to human body, no harmful substance and safe use, which is suitable for smoker and passive smoker.
Description
Technical field
The present invention is relevant with smoking abstention method, is the improvement technology about a kind of preparation of giving up smoking.
Background technology
Ministry of Public Health " " Chinese smoking is with healthy " report in 2006 " statistics shows; China in 2002 more than 15 years old crowd's smoking rate be 35.8%; Wherein the masculinity and femininity smoking rate is respectively 66.9% and 3.1%, and the smoker of China is about 3.5 hundred million people, accounts for world smoker's 1/3rd; In addition, China's smoking population has the trend of rejuvenation.According to investigations, along with the continuous reinforcement of Quan Shequan smoking cessation consciousness, have smoker over half to feel the idea of smoking cessation, the dependence to medicated cigarette is removed in 17% smoker (nearly 6,000 ten thousand people) an urgent demand.
According to World Health Organization (WHO) statistics, the whole world die from every year with the smoking diseases associated up to four million peoples, just have a people dead average each second, if do not add control, annual dead person will reach 1,000 ten thousand people to the year two thousand thirty, and China will account for 2,000,000 people.In addition, passive smoking or hazards of second-hand smoke are also very huge, and Epidemiological study shows that the women's of husband's smoking lung cancer morbidity rate is husband non-smoker 1.6-3.4 times.
Experimental result shows, contains more than 2000 kind of material in the smog during smoking, and wherein nicotine accounts for more than 90% of all biological alkali, and it mainly acts on people's cholinergic system, makes cholinoceptor cause excitement earlier, and then changes long-time inhibition over to.Simultaneously; Nicotine also from promoting adrenal medulla and other parts to discharge catecholamine, causes the heart rate quickening, and hypertension and cardiac output increase; And free fatty acid increases in peripheral vessel contraction and the blood; Nicotine is to this earlier excited back inhibitory action of each organ, decapacitation make nervous system occur trembling with spasm outside, also can cause chronic bronchitis, pulmonary carcinoma, emphysema, cardiovascular diseases, digestive system and ulcer etc.The anemia of pregnant woman restrains the smoking meeting influences fetal development.
The effective smoking abstention method of current domestic and international application comprises pharmacotherapy, acupuncture and moxibustion treatment, hypnotherapy, aversive therapy and guarded against method of giving up smoking etc. on the 5th.Domestic smoking cessation product roughly is divided three classes: a kind of smoking cessation product that is based on Nicotine replacement therapy; A kind of is the traditional Chinese medicines goods; A kind of is other smoking cessation product, like laser smoking cessation machine, smoking cessation card, smoking cessation filter plug etc.
The most general in the world Therapeutic Method is exactly a Nicotine replacement therapy of avoiding result of combustion of tobacco at present; It is the mode of more effectively giving up smoking at present; But some nearest researchs show; Smokeless tobacco goods user and the physiognomy ratio that does not contact any tobacco product, the risk of using the people of smokeless tobacco goods to suffer from esophageal carcinoma are not contact 3 times of any tobacco product person, and the risk that gets a cancer of the stomach also exceeds 40% than the latter.
CN1931357A patent of invention and some commercially available smoking cessation products have instructed with some Chinese herbal medicine extracts and have been mixed with the smoking cessation product, through smelling into the mode administration, the people is produced Nicotiana tabacum L. detest sense, thereby reach the purpose of smoking cessation, have improved the smoking cessation effect.The product but these are given up smoking; Judge from the prescription and the preparation technology of its disclosure, belong to through smelling and the ES is produced feel sick sensation into bad smell, thus refusal smoking; Reach the smoking cessation purpose, also contain volatile material such as harmful sulfide, iodine in the prescription that has.
Summary of the invention
The object of the present invention is to provide a kind of smoking cessation effect remarkable, use the safer preparation of giving up smoking easily.
Compound essential oil for controlling smoke and giving up smoking provided by the invention; Its characteristics are wherein to include the natural aromatic quintessence oil; It is that folk prescription essential oil component by following weight portion constitutes: Western Regions Herba Saussureae Involueratae 10-50, Dalbergia sisso Roxb incense wood 10-50, Chamomile 10-50, French bodhi 10-50, Myrrha 0-30, Garden lavender 10-20, Cortex Cinnamomi 0-30, Flos lupuli (Flos Humuli Lupuli) 10-50, Egyptian jasmine 10-50, Olibanum 10-20, Fructus Citri Limoniae 10-20, Lignum Aquilariae Resinatum 10-20, Herba Houttuyniae 10-20, Pericarpium Zanthoxyli 0-30, Flos Osmanthi Fragrantis 0-30, Mentholum 10-30, Borneolum Syntheticum 10-30, green tea 10-20, Radix Aucklandiae 10-50, Fructus Citri sinensis 10-50, Herba Rosmarini Officinalis 0-30, Anthemis nobilis 10-50, fragrant Ramulus Et Folium Picrasmae 10-50, Flos Lonicerae 10-50, Herba Pogostemonis 10-30, artificial Moschus 0-30, Rhizoma Cyperi 10-50, Italian orange blossom 0-30, Herba Hyperici perforati 10-30, Semen Myristicae 10-20, Flos Caryophylli 10-20, Radix Angelicae Sinensis 10-20, propolis 10-20; Add to 1000 with olive oil or Jojoba oil at last, be mixed with said compound essential oil for controlling smoke and giving up smoking.
Tobacco Control of the present invention, smoking cessation compound essential Oil at first will be processed the folk prescription quintessence oil to some components earlier, and then according to above-mentioned formula prepared cost product.The volatile oil component of indication wherein, what have can directly buy relevant folk prescription quintessence oil from market.Can't buy the component such as component such as Herba Saussureae Involueratae, Cortex Cinnamomi, Flos Osmanthi Fragrantis, Herba Houttuyniae, Pericarpium Zanthoxyli, the Radix Aucklandiae, green tea, Flos Lonicerae, Rhizoma Cyperi, Semen Myristicae, Flos Caryophylli, Radix Angelicae Sinensis, propolis of folk prescription quintessence oil commodity on the market; Then available known conventional method for distilling; Earlier process corresponding folk prescription quintessence oil to these components respectively, carry out the preparation of product of the present invention according to above-mentioned prescription more thereafter.The preparation technology of these natural folk prescription quintessence oils, sum up to get up can from following three kinds of technologies, select:
1., raw material → pulverizing → supercritical extraction → refining → folk prescription quintessence oil;
2., raw material → pulverizing → percolation → chromatography → concentrated → folk prescription quintessence oil;
3., raw material → pulverizing → vapor distillation → refining → folk prescription quintessence oil.
The Tobacco Control that is mixed with by the present invention, smoking cessation compound essential Oil are a kind of good volatile compound natural volatile oils that has, and only need open bottle cap during use and smell news 5-6 second apart from the about 1cm of nose place or it is volatilized naturally, get final product for 7-8 time every day.At this moment, the various quintessence oils of smoking cessation compound essential Oil volatilize by different level; In smelling the news process, make the people produce joyful excitement earlier and loosen sense, alleviate and shift on psychology and the body, continue to suck then making the people produce detest sense, thereby suppress craving for tobacco, the amount of smoking of minimizing medicated cigarette the Nicotiana tabacum L. abnormal smells from the patient to the serious hope of smoking.In this incremental process, body is progressively adjusted and has been adapted to the decline of nicotine concentration in the blood, disappears until withdrawal symptom.These article are made up of many groups of natural famous and precious quintessence oils; Special body constitution to the smoker; Have that tranquillizing and allaying excitement, relieving cough and resolving phlegm are relievingd asthma, heat-clearing and toxic substances removing, antioxidation, refreshment, antidepressant, balance spirit multiple efficacies, help to eliminate psychology and the physiological discomfort of ES in the smoking cessation process.Therefore these article have also been eliminated the physiological dependence to nicotine gradually when the withdrawal human body is to the psychic dependence of nicotine, according to length of smoking and craving for tobacco size, can in 1-3 month, eliminate the dependence to medicated cigarette.
The present invention is the novel smoking cessation product through olfactory sensation smoking cessation, adopts multiplely to the human body effective natural essential oil formulated (not containing Nicotiana tabacum L. and nicotine) of giving up smoking, and goes into to reach the controlling smoke and giving up smoking purpose through snuffing.Its smoking cessation effect is according to the physiology addiction and the design of psychological addiction two aspects of smoking; When the excited serious hope smoking of smoker's nicotine addiction position, smell into these article; The quintessence oil gas molecule of strong fragrance arrives olfactory epithelium; The irritating smell nerve imports excitement into the brain olfactory center, thereby causes the excited smoker's of resistance of olfactory center nicotine addiction position.
Concrete smoking cessation step: the first step; Distinctive aromatic odor of these article and method for using; As the psychology motivation agent that can excite strong smoking cessation desire, making needs the people of smoking cessation at first to produce strong smoking cessation psychological need, thereby to inducing under the body withdrawal medicated cigarette dependence generation; Second step after human body sucks a certain amount of article, made human body produce the detest sense to the taste of medicated cigarette, body is given up medicated cigarette dependence produce negative induction, thereby gradually reduce the medicated cigarette amount of smoking of every day.
This product smoking cessation and to subtract the cigarette effect be the stimulation through olfactory sensation, excitement is reached the olfactory center of brain rapidly after, give up smoking in the nicotine addiction position of resisting in the brain.Therefore, these article are to eliminate withdrawal symptom through the activity at blocking-up addiction position to reach smoking cessation order ground.
The characteristics of these article are the substitutes that need not contain nicotine, and it is promptly convenient again rapidly to give up process.
For showing progressive of the present invention, we entrust Shandong Center for Disease Control & Prevention that Tobacco Control of the present invention, smoking cessation quintessence oil have been done The acute toxicity tests and seen table 1 and table 2.
Table 1 acute oral toxicity test result
Test shows female, the male mice LD of acute oral toxicity
50Be＞5000mg/bw, according to acute toxicity grading criteria, the true border of this sample innocuous substance.
The acute toxicity on inhalation result of the test of table 2
This test, poisoning dosage 10783mg/m
3, do not cause the obvious toxic reaction of animal, do not cause animal dead, LD
50H all＞10000mg/m
3According to acute toxicity grading criteria, the true border of the acute toxicity on inhalation of this sample is nontoxic.
The present invention has further done clinical trial.Tried voluntary ES's 157 examples, wherein 155 examples are the male, and two examples are the women, and occupation comprises the company clerk, teacher, medical personnel, student etc., age 18-69 year; The smoking situation; Experimenter everyone smoking capacity 1-50 every day props up; Average 17.5, slight smoker's (every day, 1-9 propped up) 18.1%, moderate smoker's (every day, 10-19 propped up) accounts for 31.6%; Heavy smoker (every day is more than 20) accounts for 1 year-45 years 50.3% length of smoking, has 1/3rd people to attempt two or more smoking abstention methods and does not obtain and give up smoking successfully.
Feedback result after two months: wherein thorough ES 89 people of 157 philtrums account for 56.7%, though there are not thorough low smoking cessation cigarette amount minimizing person 56 people to account for 35.6%; Both do not had thoroughly smoking cessation, the cigarette amount does not reduce again, but smoking desire reduction person 7 people; Account for 4.4%, total effective rate is 96.7%.Tried the period average smoking capacity and be 7.6 for each person every day, its mild or moderate smoker accounts for 76.1%; The moderate smoker 15.6%; The heavy smoker accounts for 8.3%.The successful quitting rate of this product of result of the test explanation is higher, and smoker's smoking capacity and heavy smoker's ratio significantly reduce.
Annotate: total effective rate=(though the thorough ES+cigarette amount minimizing person that thoroughly do not give up smoking+both do not had end smoking cessation, the cigarette amount is minimizing again, but smoking desire reduction person)
Advantage of the present invention is clearly:
1, product of the present invention is not a Chinese medicine preparation; All adopt from natural product and form through the refining volatile oil (quintessence oil) that forms of modern volatile oil extractive techniques such as supercritical extraction, distillation, chromatography, separation; Be to have good volatile volatile oil, the people taken in good part initiatively smell news, can not produce pernicious stimulation human body; More do not contain hazardous substance, safe in utilization.
2, the mechanism of action of product of the present invention is clear and definite; Giving up smoking and subtracting the cigarette effect is through the stimulation to olfactory sensation; After excitement reached the brain olfactory center rapidly, give up smoking in the nicotine addiction position of resisting in the brain, eliminates withdrawal symptom through the activity at blocking-up addiction position and reach smoking cessation order ground.
3, product of the present invention has various health-care to human body; Special body constitution to the smoker; Tens of kinds of natural famous and precious quintessence oils have respectively that tranquillizing and allaying excitement, relieving cough and resolving phlegm are relievingd asthma, heat-clearing and toxic substances removing, antioxidation, refreshment, antidepressant, balance spirit multiple efficacies, help to eliminate psychology and the physiological discomfort of ES in the smoking cessation process.
4, product of the present invention is not only applicable to all smokers, and is applicable to passive smoking or second hand smoking person, can be used for fresh air yet, improves environment.
5, this product smoking cessation effect is remarkable, and total effective rate is more than 96.7%.
The specific embodiment
Combine embodiment that the present invention is described further below again
Embodiment 1:
Western Regions Herba Saussureae Involueratae 50g; Dalbergia sisso Roxb incense wood 50g; Chamomile 50g; France bodhi 50g; Myrrha 20g; Garden lavender 20g; Cortex Cinnamomi 30g; Flos lupuli (Flos Humuli Lupuli) 30g; Egyptian jasmine 30g; Olibanum 20g; Fructus Citri Limoniae 20g; Lignum Aquilariae Resinatum 20g; Herba Houttuyniae 20g; Pericarpium Zanthoxyli 20g; Mentholum 30g; Borneolum Syntheticum 30g; Green tea 20g; Radix Aucklandiae 50g; Fructus Citri sinensis 50g; Herba Rosmarini Officinalis 20g; Anthemis nobilis 50g; Fragrant Ramulus Et Folium Picrasmae 40g; Flos Lonicerae 50g; Radix agastaches 30g; Artificial Moschus 20g; Rhizoma Cyperi 50g; Herba Hyperici perforati 30g; Semen Myristicae 20g; Flos Caryophylli 20g; Radix Angelicae Sinensis 20g; Propolis 20g.Add olive oil at last to 1000g.
Embodiment 2:
Western Regions Herba Saussureae Involueratae 20g; Dalbergia sisso Roxb incense wood 20g; Chamomile 30g; France bodhi 50g; Garden lavender 20g; Flos lupuli (Flos Humuli Lupuli) 50g; Egyptian jasmine 20g; Olibanum 20g; Fructus Citri Limoniae 20g; Lignum Aquilariae Resinatum 20g; Herba Houttuyniae 10g; Flos Osmanthi Fragrantis 30g; Mentholum 20g; Borneolum Syntheticum 20g; Green tea 20g; Radix Aucklandiae 20g; Fructus Citri sinensis 50g; Anthemis nobilis 50g; Fragrant Ramulus Et Folium Picrasmae 40g; Flos Lonicerae 50g; Radix agastaches 20g; Artificial Moschus 10g; Rhizoma Cyperi 50g; Italy orange blossom 30g; Flos Caryophylli 10g; Herba Hyperici perforati 30g; Semen Myristicae 10g; Radix Angelicae Sinensis 20g; Propolis 20g.Add olive oil at last to 1000g.
Embodiment 3:
Western Regions Herba Saussureae Involueratae 10g; Dalbergia sisso Roxb incense wood 10g; Chamomile 10g; France bodhi 10g; Myrrha 10g; Garden lavender 20g; Cortex Cinnamomi 10g; Flos lupuli (Flos Humuli Lupuli) 50g; Olibanum 10g; Egyptian jasmine 50g; Fructus Citri Limoniae 20g; Lignum Aquilariae Resinatum 20g; Herba Houttuyniae 10g; Pericarpium Zanthoxyli 10g; Flos Osmanthi Fragrantis 10g; Mentholum 20g; Borneolum Syntheticum 20g; Green tea 20g; Radix Aucklandiae 20g; Fructus Citri sinensis 50g; Herba Rosmarini Officinalis 20g; Anthemis nobilis 50g; Fragrant Ramulus Et Folium Picrasmae 50g; Flos Lonicerae 50g; Radix agastaches 10g; Rhizoma Cyperi 30g; Italy orange blossom 30g; Herba Hyperici perforati 10g; Semen Myristicae 10g; Flos Caryophylli 20g; Radix Angelicae Sinensis 10g; Propolis 10g.Add Jojoba oil at last to 1000g.
Claims (1)
1. compound essential oil for controlling smoke and giving up smoking; It is characterized in that by the component of following weight portion formulated: Western Regions Herba Saussureae Involueratae 10-50, Dalbergia sisso Roxb incense wood 10-50, Chamomile 10-50, French bodhi 10-50, Myrrha 0-30, Garden lavender 10-20, Cortex Cinnamomi 0-30, Flos lupuli (Flos Humuli Lupuli) 10-50, Egyptian jasmine 10-50, Olibanum 10-20, Fructus Citri Limoniae 10-20, Lignum Aquilariae Resinatum 10-20, Herba Houttuyniae 10-20, Pericarpium Zanthoxyli 0-30, Flos Osmanthi Fragrantis 0-30, Mentholum 10-30, Borneolum Syntheticum 10-30, green tea 10-20, Radix Aucklandiae 10-50, Fructus Citri sinensis 10-50, Herba Rosmarini Officinalis 0-30, Anthemis nobilis 10-50, fragrant Ramulus Et Folium Picrasmae 10-50, Flos Lonicerae 10-50, Herba Pogostemonis 10-30, artificial Moschus 0-30, Rhizoma Cyperi 10-50, Italian orange blossom 0-30, Herba Hyperici perforati 10-30, Semen Myristicae 10-20, Flos Caryophylli 10-20, Radix Angelicae Sinensis 10-20, propolis 10-20 add to 1000 with olive oil or Jojoba oil at last.
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| CN200810015330A CN101264277B (en) | 2008-04-16 | 2008-04-16 | Compound essential oil for controlling smoke and giving up smoking |
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| CN101264277B true CN101264277B (en) | 2012-09-26 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102161937B (en) * | 2011-03-02 | 2013-06-05 | 广州市澳键丰泽生物科技有限公司 | Formula of tobacco flavoring essence containing hops |
| CN104027753A (en) * | 2013-03-08 | 2014-09-10 | 新加坡无烟国际集团私人有限公司 | Chinese patent medicine suitable for global tobacco control and its preparation method and use |
| CN103610061B (en) * | 2013-12-03 | 2014-10-15 | 马军保 | Health care product used by smokers |
| CN104783321B (en) * | 2015-02-11 | 2020-03-17 | 贵州中烟工业有限责任公司 | Mouth-holding type smokeless tobacco product containing hop component and preparation method thereof |
| CN109393546A (en) * | 2017-08-16 | 2019-03-01 | 王学彬 | A kind of electronic cigarette liquid and preparation method thereof comprising jasmine essential oil |
| CN107982101B (en) * | 2017-11-09 | 2020-10-09 | 恩馨（北京）生物科技有限公司 | Natural repair factor capable of effectively repairing and regenerating, preparation method and application thereof |
| CN108452207A (en) * | 2018-07-04 | 2018-08-28 | 杨金金 | A kind of smoking cessation plant oil formula of liquid |
| CN115736319A (en) * | 2022-10-10 | 2023-03-07 | 惠州市新泓威科技有限公司 | Application of jojoba oil in preparation of electronic cigarette liquid |
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| CN1345213A (en) * | 1999-03-26 | 2002-04-17 | 罗曼治疗系统股份公司 | Transdermal therapeutic system with nicotine and addition of monoterpene ketones |
| CN1197655C (en) * | 2001-09-06 | 2005-04-20 | 胡传东 | Large-amplitude centrifugal vibrating grinder |
| CN1217919C (en) * | 2003-03-07 | 2005-09-07 | 中山大学 | N,N-dimethyl glycine (E)-3,7-dimethyl-2,6-octadienel ester and preparing process and use thereof |
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2008
- 2008-04-16 CN CN200810015330A patent/CN101264277B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1345213A (en) * | 1999-03-26 | 2002-04-17 | 罗曼治疗系统股份公司 | Transdermal therapeutic system with nicotine and addition of monoterpene ketones |
| CN1197655C (en) * | 2001-09-06 | 2005-04-20 | 胡传东 | Large-amplitude centrifugal vibrating grinder |
| CN1217919C (en) * | 2003-03-07 | 2005-09-07 | 中山大学 | N,N-dimethyl glycine (E)-3,7-dimethyl-2,6-octadienel ester and preparing process and use thereof |
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