CN110367581A - It is a kind of by industrial hemp extract the ingredient containing cannabinoids composition and its purposes in tobacco product - Google Patents
It is a kind of by industrial hemp extract the ingredient containing cannabinoids composition and its purposes in tobacco product Download PDFInfo
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- CN110367581A CN110367581A CN201810327014.2A CN201810327014A CN110367581A CN 110367581 A CN110367581 A CN 110367581A CN 201810327014 A CN201810327014 A CN 201810327014A CN 110367581 A CN110367581 A CN 110367581A
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- cannabinoids
- ingredient
- mass percent
- industrial hemp
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/26—Use of organic solvents for extraction
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B3/00—Preparing tobacco in the factory
- A24B3/12—Steaming, curing, or flavouring tobacco
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/061—Use of materials for tobacco smoke filters containing additives entrapped within capsules, sponge-like material or the like, for further release upon smoking
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of composition for tobacco product, the composition includes the cannabinoids ingredient and auxiliary material extracted by industrial hemp, the mass percent of the cannabinoids ingredient extracted in the composition by industrial hemp is 0.01-10%, contain CBD and CBDV in the cannabinoids ingredient extracted by industrial hemp, the mass percent of CBD is 30-90% in the cannabinoids ingredient extracted by industrial hemp, and the mass percent of CBDV is 1-25%.The composition can be electronic cigarette liquid, quick-fried pearl or flavoring liquid, without harmful components in smog after smoker's loosening all muscles, mood can be made to be promoted and be atomized, it can also improve and enrich cigarette flavor, the fragrance for promoting cigarette is rich, the interest of aesthetic quality and suction.
Description
Technical field
The present invention relates to tobacco product fields, contain the cannabinoids ingredient extracted by industrial hemp more particularly to a kind of
Composition and its application in electronic cigarette liquid and quick-fried pearl.
Background technique
Cigarette is generally existing in people's lives as a kind of preference.There is survey report to claim, population of China smoking rate is
27.7%, and the annual rapid growth of number of smokers.With human health realize improve, smoke for health influence increasingly by
To the concern of people.Containing a variety of chemical substances such as nicotine, smoke tar, hydrogen cyanide, aldehyde in conventional cigarette smog, ingredient is very
Complexity, estimation contain 3500 multiple compounds.Wherein, nicotine is also known as nicotine, and nicotine can be addicting or generate dependence,
Nicotine is reused also to increase heart speed and increase blood pressure and reduce appetite, large dosage of nicotine can cause vomiting and
Nausea can lead to death when serious.Smoke tar is extremely harmful to human health, wherein having tens of constituent is carcinogen.It is fragrant
Many substances are proved to have carcinogenic, teratogenesis, mutagenic effect in cigarette smog.People during smoking, cigarette it is water-soluble
Property part can by the mucus of alveolar surface absorb and dissolve, thus body is caused greatly to damage.The tumour of the mankind 30% and
It smokes related, it follows that smoke from cigarette is carcinogenic important sources.Long-term smoking damages respiratory system, the circulatory system, causes
Various chronic diseases.
Due to it has been realized that smoking to significant damage caused by human body, so countries in the world all take smoking ban
Or the measure of tobacco control, but nicotine is additive, keeps Successful smoking cessation difficult to realize, in this case, there is " nicotine replacement treatment
The electronic cigarette of the title of method " comes into being, and nicotine maximum level is the 1/3 of common cigarette, also there is the electricity without nicotine
Sub- cigarette, but since its mouthfeel and the feeling sucked and common cigarette have larger difference, it is extremely difficult to the effect of substitution common cigarette
Fruit.The prior art has done many improvement to electronic cigarette liquid, as Chinese patent CN104287084A discloses a kind of burnt odor electronic cigarette
Liquid, make the taste of electronic cigarette close to conventional cigarette and fragrance it is pure, but be not still the mouthfeel of cigarette, and be pipe tobacco or offal
Distillation gained, complicated component, the still ingredient containing harmful health.For another example Chinese patent CN101461565A discloses one
Kind has medicative electronic cigarette liquid, but its formula is complicated, mouthfeel is poor, and is not people drug being added in electronic cigarette
Body security verification.
On the other hand, in order to strengthen the fragrance of cigarette, smoker is made to obtain more comfortably experiencing, part of the manufacturer is in cigarette
Filter tip is built into the quick-fried pearl of liquid, and liquid component is mostly fragrance, pinches brokenly quick-fried pearl before smoking, not only body when aspirating consumer
Quick-fried pearl bring enjoyment is tested, the fragrant of cigarette can also be enjoyed and moisten mouthfeel and special fragrance.In the prior art, patent
CN107115485A discloses a kind of quick-fried pearl of Chinese herbal medicine and quick-fried pearl cigarette holder, can reach alleviate smokers' cough, abundant expectoration, pharynx are itched, mouth
Dry effect.Patent CN107022415A discloses a kind of quick-fried pearl boat-fruited sterculia essence of cigarette, after which is placed in cigarette filter,
Cigarette irritation can preferably be weakened, improve and interest is aspirated in abundant cigarette flavor, promotion.It can be seen that the prior art is quick-fried
Traditional Chinese medicine ingredients are added in pearl to alleviate stimulation of the smog to smoker's throat, but its fragrance for also changing cigarette, Bu Nengman
The demand of sufficient smoker.
Cannabinol compounds are a distinctive substances in hemp plant, are main active constituents in cannabis plants,
Research in relation to it is always the hot spot of hemp research.Main cannabinoids ingredient has cannabinol (CBN), big in hemp plant
Numb diphenol (CBD), cannabidivarin (CBDV), cannabigerol (CBG), tetrahydrocannabinol (THCV), tetrahydrocannabinol (THC)
Deng.Wherein THC can make one to cause unreal habituation, can make drugs, once forbid cultivating within suitable long-term, still, due to the economy of hemp, medicine
High with being worth, the raw material hemp for specializing in industrial use is referred to as " industrial hemp ", the THC content in growth period hemp floral leaf
Less than 3/1000ths, do not have extract toxic component tetrahydrocannabinol value or sucked directly as drugs, can it is legal into
Row large-scale planting and industrialized developing utilize, and the hemp refers both to industrial hemp in the present invention.Above-mentioned phenolic substances is
It is proven to have very strong pharmacological activity, especially CBD, since it more becomes research hotspot, CBD with a variety of pharmacological activity
Without neurotoxicity, influence of the THC to nerve system of human body can be hindered, and there is apparent anti-spasm, antirheumatic to close
The pharmacological activity such as inflammation, antianxiety are saved, there is huge industry development value；CBD and THCV can influence lipid and glycometabolism, Ke Nengcheng
For the new selection for controlling type 2 diabetic patient's blood glucose；CBDV have preferable antiepileptic activity, while some researches show that CBDV can
Mitigate nausea, helps to treat gastrointestinal problems.
In view of the various active that cannabinoids ingredient has, existing patent report adds CBD in electronic cigarette liquid, such as
US20150181924A1 discloses a kind of composition that can be used as electronic cigarette liquid, and the composition includes CBD and at least one cream
Agent, the CBD content are 0.1%-90%, and the emulsifier content is 10%-99.9%.CBD can pass through mouth after being atomized
Chamber and lung mucosa absorption, and this electronic cigarette liquid will not generate side effect to the lung of smoker.However, single in electronic cigarette liquid
CBD ingredient be still unable to satisfy consumer for electronic cigarette mouthfeel and more multi-functional pursuit.
In order to overcome the defects of the prior art, contain the cannabinoids extracted by industrial hemp the present invention provides a kind of
The composition of ingredient and its application in tobacco product, the smog after smoker's loosening all muscles, mood can be made to be promoted and be atomized
In be free of harmful components.
Summary of the invention
The present invention provides a kind of composition for tobacco product, and the composition includes the hemp extracted by industrial hemp
Phenols component and auxiliary material, the mass percent of the cannabinoids ingredient extracted in the composition by industrial hemp are 0.01-
10%, it is described by industrial hemp extract cannabinoids ingredient in contain CBD and CBDV, it is described by industrial hemp extract hemp
The mass percent of CBD is 30-90% in phenols component, and the mass percent of CBDV is 1-25%.
Preferably, the mass percent of the cannabinoids ingredient extracted in the composition by industrial hemp is 0.01-
5%, it is furthermore preferred that the mass percent of the cannabinoids ingredient extracted in the composition by industrial hemp is 0.01-2%.
Preferably, the mass percent containing CBD is 30- in the cannabinoids ingredient extracted by industrial hemp
75%, it is furthermore preferred that the mass percent containing CBD is 40-65% in the cannabinoids ingredient extracted by industrial hemp.
Preferably, the mass percent containing CBDV is 5- in the cannabinoids ingredient extracted by industrial hemp
15%.
In an embodiment of the invention, also contain in the cannabinoids ingredient extracted by industrial hemp
CBG and/or THCV.
Preferably, the mass percent containing CBG is 1-25% in the cannabinoids ingredient extracted by industrial hemp,
It is furthermore preferred that the mass percent containing CBG is 5-12% in the cannabinoids ingredient extracted by industrial hemp.
Preferably, the mass percent containing THCV is 0.1- in the cannabinoids ingredient extracted by industrial hemp
20%, it is furthermore preferred that the mass percent containing THCV is 1-12% in the cannabinoids ingredient extracted by industrial hemp.
Cannabinoids ingredient of the present invention can be chemosynthesis product, biosynthetic products, plant extracts or
It is prepared using other modes.Preferably, cannabinoids ingredient of the present invention is plant extracts, it is furthermore preferred that institute
The plant extracts stated be industrial hemp extract, the Cannador can be each ingredient is extracted respectively after combine,
If CBD is combined with CBDV, CBD, CBDV are combined with CBG, and CBD, CBDV are combined with THCV, CBD, CBDV, CBG and THCV group
It closes；Be also possible to extract to obtain the extract containing each ingredient, such as extract containing CBD and CBDV simultaneously, containing CBD, CBDV and
The extract of CBG, the extract containing CBD, CBDV and THCV, the extract containing CBD, CBDV, CBG and THCV.
In an embodiment of the invention, the cannabinoids constituents extraction step packet extracted by industrial hemp
It includes:
(1) extract part of hemp is crushed, baking obtains medicinal powder；
(2) by medicinal powder solvent extraction obtained by step (1), extracting solution is obtained；
(3) extracting solution obtained by step (2) is concentrated, is separated by solid-liquid separation, takes supernatant；
(4) supernatant obtained by step (3) is crossed into adsorption column, elutes, obtains eluent；
(5) eluent obtained by step (4) is concentrated, purifying obtains Cannador.
Preferably, hemp described in step (1) is selected from the combination of one or both of industrial hemp or medicinal hemp；
More preferably industrial hemp.
Preferably, extract part described in step (1) is selected from: marihuana, cannabis, cannabis root, hemp stalk core, hemp
The combination of the combination arbitrary proportion of one or more of the seed dregs of rice, hempseed, hemp shell；It is furthermore preferred that the extraction
Position is cannabis and/or marihuana.
Preferably, solvent described in step (2) is methanol, ethyl alcohol, chloroform and acetonitrile, it is furthermore preferred that the solvent is
Ethyl alcohol；The concentration of alcohol be 60-95% (v/v, it is specific such as 60%, 70%, 80%, 90% or 95%), more preferably 90%.
Preferably, concentration described in step (3) for by extracting solution be concentrated into alcoholic strength 40-70% (it is specific such as 40%,
50%, 60%, 65% or 70%).
Preferably, absorption column packing described in step (4) is selected from: HPD series, ADS series, HZ series, XAD series
With the combination of one or more of D series macroreticular resin filler；It is furthermore preferred that the absorption column packing is selected from:
The combination of one or more of HPD100, HZ18 and D101.
Preferably, elution described in step (4) is gradient elution.
Preferably, purification step described in step (5) includes: column chromatography and/or crystallization.
In an embodiment of the invention, the composition is electronic cigarette liquid, and the electronic cigarette liquid includes by industry
The cannabinoids ingredient and solvent that hemp is extracted.
The solvent is selected from but not limited to: glycerine, propylene glycol, polyethylene glycol, diethylene glycol (DEG), triethylene glycol, ethyl alcohol, purified water
One or more of combination.
Preferably, the solvent is selected from: one or more of glycerine, propylene glycol, polyethylene glycol, purified water
Combination, it is furthermore preferred that the solvent is selected from the combination of one or both of glycerine and polyethylene glycol 400.
Preferably, the mass percent of solvent is 57-99.99% in the composition, it is furthermore preferred that the matter of the solvent
Amount percentage is 85-99%.
In an embodiment of the invention, the electronic cigarette liquid also contains stabilizer, and the stabilizer is selected from: the third three
One or more of alcohol, syrup, pectin, konjac glucomannan, xanthan gum, modified modified starch, sodium alginate, Sodium Caseinate
Combination.
Preferably, the stabilizer is selected from the combination of one or more of glycerine, syrup, pectin.
Preferably, the mass percent of stabilizer is 0-12% in the composition, it is furthermore preferred that steady in the composition
The mass percent for determining agent is 0.1-12%.
In an embodiment of the invention, the electronic cigarette liquid also contains preservative, and the preservative is selected from: benzene first
The combination of one or more of sour sodium, methylparaben, ethylparaben.
Preferably, the mass percent of preservative is 0-1% in the composition, it is furthermore preferred that preventing in the composition
The mass percent of rotten agent is 0.1-1%.
In an embodiment of the invention, the electronic cigarette liquid also contains tobacco essence, and the tobacco essence is selected from:
It is apple, cherry, green tea, cortex cinnamomi, cloves, black tea, plum, mango, jujube, watermelon, coconut, pears, jasmine, peach, fennel, fragrant and sweet
Melon, lichee, peppermint, chocolate, coffee, cream, banana, almond, grape, strawberry, blueberry, blackberry, blueberry, pineapple, Kiwi berry, olive,
The essence of the odor types such as orange, lemon, watermelon, rose, sweet osmanthus, cucumber and honey.
Preferably, the mass percent of tobacco essence is 0-5% in the composition, it is furthermore preferred that in the composition
The mass percent of tobacco essence is 2-5%.
In an embodiment of the invention, the electronic cigarette liquid also contains drug ingedient, and the drug ingedient is selected from:
The combination of one or more of vitamin C, vitamin B2, oryzanol, ginseng, Radix Glycyrrhizae, the root of straight ladybell, campanulaceae and ephedrine.
Preferably, the drug ingedient is selected from: one or both of vitamin C, vitamin B2, oryzanol, Radix Glycyrrhizae with
On combination.
Preferably, the mass percent of the combination of traditional Chinese medicine object ingredient is 0-15%, it is furthermore preferred that in the composition
The mass percent of drug ingedient is 3-15%.
Electronic cigarette liquid of the present invention can use the tobacco juice preparation method of this field routine, such as will be by industrial hemp
The cannabinoids ingredient of extraction is dissolved in solvent, is uniformly mixed using propeller, magnetic stirring apparatus or shaking device to get electronics
Tobacco juice；Or the cannabinoids ingredient extracted by industrial hemp is dissolved in solvent, it is fragrant to add stabilizer, preservative, tobacco
The combination of one or more of smart or drug ingedient is uniformly mixed using propeller, magnetic stirring apparatus or shaking device,
Up to electronic cigarette liquid.
In another embodiment of the present invention, the composition is quick-fried pearl, and the quick-fried pearl includes being extracted by industrial hemp
Cannabinoids ingredient, solvent and adhesive.
The solvent is selected from: one of glycerine, propylene glycol, polyethylene glycol, diethylene glycol (DEG), triethylene glycol, ethyl alcohol, purified water
Or two or more combination.
Preferably, the solvent is selected from: one or more of glycerine, propylene glycol, polyethylene glycol, purified water
Combination, it is furthermore preferred that the solvent is selected from the combination of one or both of glycerine and polyethylene glycol 400.
Preferably, the mass percent of the solvent is 40-60%, it is furthermore preferred that the mass percent of the solvent is
45-55%.
Described adhesive is selected from: hydroxypropyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, ethyl cellulose, hydroxypropyl
Ylmethyl cellulose, starch, superfine silica gel powder, starch slurry, syrup, maltose, refined honey, polyvinylpyrrolidone, gathers microcrystalline cellulose
Tie up one of ketone, liquid glucose, cellulose derivative, sodium alginate, polyethylene glycol, aluminum magnesium silicate, gelatin, tragacanth
Or two or more combination.
Preferably, described adhesive is selected from the group of one or more of carboxymethyl cellulose, povidone, gelatin
It closes.
Preferably, the mass percent of adhesive is 30-50% in the composition.
In an embodiment of the invention, also contain plasticizer in the quick-fried pearl, the plasticizer be selected from sorbierite,
The combination of one or more of mannitol or ethylene glycol；
Preferably, the mass percent of plasticizer is 0-5% in the composition, it is furthermore preferred that increasing in the composition
The mass percent for moulding agent is 1-5%.
In an embodiment of the invention, also contain preservative in the quick-fried pearl, the preservative is selected from but unlimited
In: the combination of one or more of sodium benzoate, methylparaben, ethylparaben.
Preferably, the mass percent of preservative is 0-1% in the composition, it is furthermore preferred that preventing in the composition
The mass percent of rotten agent is 0.1-1%.
In an embodiment of the invention, also contain tobacco essence in the quick-fried pearl, the tobacco essence is selected from: apple
Fruit, cherry, green tea, cortex cinnamomi, cloves, black tea, plum, mango, jujube, watermelon, coconut, pears, jasmine, peach, fennel, fragrant and sweet melon,
Lichee, peppermint, chocolate, coffee, cream, banana, almond, grape, strawberry, blueberry, blackberry, blueberry, pineapple, Kiwi berry, olive, orange
The essence of the odor types such as son, lemon, watermelon, rose, sweet osmanthus, cucumber and honey.
Preferably, the mass percent of tobacco essence is 0-5% in the composition, it is furthermore preferred that in the composition
The mass percent of tobacco essence is 3-5%.
In an embodiment of the invention, also contain drug ingedient in the quick-fried pearl, the drug ingedient is selected from: dimension
The combination of one or more of raw element C, vitamin B2, oryzanol, ginseng, Radix Glycyrrhizae, the root of straight ladybell, campanulaceae and ephedrine.
Preferably, the drug ingedient is selected from: one or both of vitamin C, vitamin B2, oryzanol, Radix Glycyrrhizae with
On combination.
Preferably, the mass percent of the combination of traditional Chinese medicine object ingredient is 0-15%, it is furthermore preferred that in the composition
The mass percent of drug ingedient is 3-15%.
Quick-fried pearl of the present invention can use the quick-fried pearl preparation method of this field routine, such as:
(1) by water and adhesive Hybrid Heating, thawing；
(2) the cannabinoids ingredient extracted by industrial hemp is dissolved in solvent, optional, it is fragrant that plasticizer, tobacco is added
The combination of one or more of essence, preservative, drug ingedient, it is mixed using propeller, magnetic stirring apparatus or shaking device
It closes uniform；
(3) liquid that step (1) and (2) obtains is introduced into dripping equipment, obtains wet ball；
(4) calcification, oil suction and dry quick-fried pearl.
Preferably, the quick-fried pearl diameter is 2.6mm-4.6mm.It is further preferred that the quick-fried pearl diameter is
3.0mm-4.2mm。
Quick-fried pearl of the present invention can be placed in the middle part of cigarette filter, before suction or pinch quick-fried in aspiration procedure or break by the teeth.
In an embodiment of the invention, the composition is flavoring liquid, and the flavoring liquid includes by industrial hemp
The cannabinoids ingredient and solvent of extraction.
The solvent is selected from: one of purified water, ethyl alcohol, glycerine, propylene glycol, polyethylene glycol, diethylene glycol (DEG), triethylene glycol
Or two or more combination.
Preferably, the solvent is selected from: one or both of purified water, ethyl alcohol, glycerine, propylene glycol, polyethylene glycol
Above combination, it is furthermore preferred that the solvent is selected from the combination of one or both of purified water, ethyl alcohol.
Preferably, the mass percent of solvent is 57-99.99% in the composition, it is furthermore preferred that the matter of the solvent
Amount percentage is 85-99%.
In an embodiment of the invention, the flavoring liquid also contains stabilizer, and the stabilizer is selected from: the third three
One or more of alcohol, syrup, pectin, konjac glucomannan, xanthan gum, modified modified starch, sodium alginate, Sodium Caseinate
Combination.
Preferably, the stabilizer is selected from the combination of one or more of glycerine, syrup, pectin.
Preferably, the mass percent of stabilizer is 0-12% in the composition, it is furthermore preferred that steady in the composition
The mass percent for determining agent is 0.1-12%.
In an embodiment of the invention, the flavoring liquid also contains preservative, and the preservative is selected from: benzoic acid
The combination of one or more of sodium, methylparaben, ethylparaben.
Preferably, the mass percent of preservative is 0-1% in the composition, it is furthermore preferred that preventing in the composition
The mass percent of rotten agent is 0.1-1%.
In an embodiment of the invention, the flavoring liquid also contains tobacco essence, and the tobacco essence is selected from: apple
Fruit, cherry, green tea, cortex cinnamomi, cloves, black tea, plum, mango, jujube, watermelon, coconut, pears, jasmine, peach, fennel, fragrant and sweet melon,
Lichee, peppermint, chocolate, coffee, cream, banana, almond, grape, strawberry, blueberry, blackberry, blueberry, pineapple, Kiwi berry, olive, orange
The essence of the odor types such as son, lemon, watermelon, rose, sweet osmanthus, cucumber and honey.
Preferably, the mass percent of tobacco essence is 0-5% in the composition, it is furthermore preferred that in the composition
The mass percent of tobacco essence is 2-5%.
In an embodiment of the invention, the flavoring liquid also contains drug ingedient, and the drug ingedient is selected from: dimension
The combination of one or more of raw element C, vitamin B2, oryzanol, ginseng, Radix Glycyrrhizae, the root of straight ladybell, campanulaceae and ephedrine.
Preferably, the drug ingedient is selected from: one or both of vitamin C, vitamin B2, oryzanol, Radix Glycyrrhizae with
On combination.
Preferably, the mass percent of the combination of traditional Chinese medicine object ingredient is 0-15%, it is furthermore preferred that in the composition
The mass percent of drug ingedient is 3-15%.
The present invention also provides a tobacco articles, the tobacco product include by industrial hemp extract cannabinoids at
Point and tobacco leaf, the mass percent of the cannabinoids ingredient extracted by industrial hemp in the tobacco product be 0.01-1%, institute
State in the cannabinoids ingredient extracted by industrial hemp containing CBD and CBDV, the cannabinoids extracted by industrial hemp at
The mass percent of CBD is 30-90% in point, and the mass percent of CBDV is 1-25%.Preferably, described by industrial hemp
Also contain CBG and/or THCV, CBG in the cannabinoids ingredient extracted by industrial hemp in the cannabinoids ingredient of extraction
Mass percent be 1-25%, THCV mass percent be 0.1-20%
Preferably, the mass percent of the cannabinoids ingredient extracted in the tobacco product by industrial hemp is 0.05-
0.5%；
Preferably, the preparation method of the tobacco product includes: that flavoring liquid of the present invention is prepared, and tobacco leaf is soaked
It steeps among flavoring liquid, stands, be dried to obtain, or the spray of flavoring liquid is added on tobacco leaf, be dried to obtain.
Preferably, the flavoring liquid dilutes 1-10 times before spray adds or impregnates.
Preferably, the mode of the drying includes carrying out tobacco leaf at 45-70 DEG C to dry under baking or room temperature.
The present invention provides a kind of electronic cigarette liquid, and fragrance is suitable with conventional cigarette, and smoker's loosening all muscles, mood can be made to mention
Harmful components are free of in smog after rising and being atomized；After drug ingedient is added in electronic cigarette liquid, smog pair can be effectively relieved
The effect of smoker's throat irritation has clearing throat, enhances body immunity；It is described quick-fried the present invention also provides a kind of quick-fried pearl
Pearl is applied in quick-fried pearl cigarette holder, after the quick-fried pearl merging cigarette filter, can preferably weaken the irritation of cigarette, improve and enrich volume
Cigarette perfume gas, the fragrance for promoting cigarette is rich, the interest of aesthetic quality and suction；Furthermore the present invention provides a kind of flavoring liquid,
For tobacco leaf or the flavoring of pipe tobacco, improvement and abundant cigarette flavor promote the aesthetic quality of cigarette and the interest of suction.
Specific embodiment
Unless otherwise defined, all technical and scientific terms used herein have with the present invention relates to the technologies in field
The normally understood identical meaning of personnel, the following abbreviation such as occurred in the present invention and its corresponding substance are as follows:
CBDV cannabidivarin
CBD cannabidiol
CBG cannabigerol
THCV tetrahydrocannabinol
THC tetrahydrocannabinol
CBN cannabinol
BV column volume
Below in conjunction with the embodiment of the present invention, technical solution of the present invention is clearly and completely described, it is clear that institute
The embodiment of description is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, originally
Field those of ordinary skill every other embodiment obtained without creative efforts, belongs to the present invention
The range of protection.
Hemp extract part raw material used in the embodiment of the present invention are as follows: floral leaf raw material is the mature hemp floral leaf of the 7-9 month,
It is THC content in 0.3% industrial hemp below through peasant household's preliminarily dried.Unless stated otherwise, other reagents are commercially available production
Product.
The preparation for the cannabinoids ingredient that embodiment 1 is extracted by industrial hemp
(1) crushing industrial hemp flower, leaf raw material is 40 mesh coarse powder, at 110 DEG C, toasts 80min, is surveyed moisture and is
3.6%；
(2) by medicinal material obtained by step (1) with 10 times of 95% ethyl alcohol soaking at room temperature 2h, cold-maceration is extracted 3 times, is merged gained and is mentioned
Take liquid；
(3) it is concentrated into alcoholic strength 50% by 55 DEG C of extracting solution obtained by step (2), 95% ethyl alcohol rectification precision, which is added, is
60%, sedimentation overnight, obtains supernatant；
(4) supernatant obtained by step (3) is crossed into 100 resin of macropore HPD, to purify washing 2BV, 25% ethanol washing
4BV is collected since liquid chromatogram checks CBDV, until detect that CBDV concentration stops collecting lower than 0.5g/L, rest part
Make devil liquor recovery solvent；It again with 45% ethanol elution 4BV, is collected since liquid phase checks CBG, until detecting that CBG concentration is low
Stop collecting in 0.5g/L；It again with 70% ethanol elution 4BV, is collected since liquid phase checks THCV, until detecting that THCV is dense
Degree stops collecting lower than 0.5g/L；It again with 90% ethanol elution 4BV, is collected since liquid phase checks CBD, until detecting CBD
Concentration stops collecting lower than 0.5g/L；Finally, column 3BV is rushed with 95% ethyl alcohol, until efflux near colorless is transparent；
(5) by 4 components obtained by step (4), be concentrated respectively: component 1-4 is concentrated into alcoholic strength 55%, respectively upper quadratic-layer
Column is analysed, filler is respectively decolorizing resin HP20 and ADS7；
(6) component 1 resulting for step (5), with 55% alcohol impurity-removing 3BV, then with 65% ethanol elution, obtains CBDV
Eluent；Component 2 with 60% ethyl alcohol removal of impurities 4BV, then with 70% ethanol elution, obtains CBG eluent；Component 3, with 60% ethyl alcohol
Clean 4BV, then with 75% ethanol elution, obtains THCV eluent；Component 4 is cleaned 4BV with 70% ethyl alcohol, then is washed with 90% ethyl alcohol
It is de-, obtain CBD eluent；
(7) it by the resulting four groups of eluents of step (6), is concentrated under reduced pressure respectively, 55-70 DEG C, -0.10MPa, until concentrate
Obvious milky turbidity is begun with, is stopped, tapping is placed in 4-10 DEG C of freezer crystallization 12-48h respectively；
(8) the resulting four groups of crystalline mother solutions of step (7) are discharged, recycling, and crystal are shoveled respectively broken, filtered to dry, then
With the elution of a small amount of purified water until efflux clear, colorless, digs out crystal, be placed in 30-50 DEG C of vacuum drying, -0.10MPa, 24-
36h, until determination of moisture is 2% hereinafter, getting product.
It is 98.45%, CBG purity through HPLC measurement CBDV purity be 99.22%, THCV purity is that 98.07%, CBD is pure
Degree is 99.30%.
Four kinds of ingredients are mixed to get cannabinoids substance, the cannabinoids extracted by industrial hemp by a certain percentage
The mass percent that the mass percent that the mass percent of CBD is 65%, CBDV in ingredient is 15%, CBG is 12%,
The mass percent of THCV is 8%, can also be combined with other any ratios.
The preparation for the cannabinoids ingredient that embodiment 2 is extracted by industrial hemp
(1) crushing industrial hemp floral leaf raw material is 60 mesh coarse powder, at 150 DEG C, toasts 30min, is surveyed moisture and is
3.2%；
(2) by medicinal material obtained by step (1) with 11 times of 95% ethyl alcohol soaking at room temperature 2h, cold-maceration is extracted 3 times, merges to extract
Liquid；
(3) it is concentrated into alcoholic strength 72% by 65 DEG C of extracting solution obtained by step (2), plate-frame filtering obtains supernatant；
(4) supernatant obtained by step (3) is crossed into HZ18 macroreticular resin, to purify washing 3BV, first with 20% ethanol washing
5BV, then with 80% ethanol elution 6BV, merge eluent；
(5) eluent obtained by step (4) is concentrated, is concentrated into alcoholic strength 55%, respectively upper secondary chromatographic column, filler
Respectively DM130 and MCI；
(6) it for step (5) resulting concentrate, is washed with 90% ethyl alcohol and acetonitrile with the eluent that 10:1 is made into
It is de-, obtain eluent；
(7) the resulting eluent of step (6) is concentrated under reduced pressure, 55-70 DEG C, -0.10MPa, until stiff paste；
(8) by step (7) resulting stiff paste at 50 DEG C, 50 times of amount water and 5 times of amount acetone is added, filter while hot, room temperature
It stands, room temperature to be restored, it is seen that crystal is precipitated in side wall and bottom, is placed in the crystallization of 4-10 freezer；
(9) crystal obtained by step (8) is recycled, is filtered to dry, then with the elution of a small amount of purified water until the transparent nothing of efflux
Color digs out crystal, is placed in 40-50 DEG C of vacuum drying, -0.10MPa, 24-36h, until determination of moisture 2% hereinafter, up at
Product.
The mass percent that mass percent through CBD in HPLC measurement products obtained therefrom is 60%, CBDV is 15%, CBG
Mass percent be 12%, THCV mass percent be 10%.
The preparation of 3 electronic cigarette liquid of embodiment
A kind of electronic cigarette liquid mainly forms as shown in the table:
A kind of electronic cigarette liquid component list of table 1
It is prepared by the cannabinoids ingredient that industrial hemp extracts according to embodiment 1 in table 1, wherein the quality hundred of CBD
Dividing the mass percent that ratio is 65%, CBDV is 15%, and the mass percent that the mass percent of CBG is 12%, THCV is
8%.
The electronic cigarette liquid preparation step are as follows: the cannabinoids ingredient extracted by industrial hemp is dissolved in solvent glycerine
In purified water, syrup and preservative sodium benzoate is added after to be dissolved, is eventually adding tobacco essence, be sufficiently stirred to get
Electronic cigarette liquid.
The preparation of 4 electronic cigarette liquid of embodiment
A kind of electronic cigarette liquid mainly forms as shown in the table:
A kind of electronic cigarette liquid component list of table 2
It is prepared by the cannabinoids ingredient that industrial hemp extracts according to embodiment 2 in table 2, wherein the quality hundred of CBD
The mass percent that the mass percent that the mass percent that score is 60%, CBDV is 15%, CBG is 12%, THCV is
10%.
The electronic cigarette liquid preparation step are as follows: be first dissolved in the cannabinoids ingredient extracted by industrial hemp with glycerine poly-
In ethylene glycol 400 and purified water, preservative sodium benzoate and tobacco essence is added after to be dissolved, is sufficiently stirred to get electronic cigarette
Liquid.
The preparation of 5 electronic cigarette liquid of embodiment
A kind of electronic cigarette liquid mainly forms as shown in the table:
A kind of electronic cigarette liquid component list of table 3
It is prepared by the cannabinoids ingredient that industrial hemp extracts according to embodiment 2 in table 3, wherein the quality hundred of CBD
The mass percent that the mass percent that the mass percent that score is 60%, CBDV is 15%, CBG is 12%, THCV is
10%.
The electronic cigarette liquid preparation step are as follows: drug ingedient vitamin C and Radix Glycyrrhizae first are dissolved with a small amount of purified water, it will be by work
The cannabinoids ingredient and glycerine that sparetime university fiber crops are extracted are dissolved in polyethylene glycol 400 and purified water, and vitamin is added after to be dissolved
C, Radix Glycyrrhizae, methylparaben, are sufficiently stirred, and tobacco essence is added to get electronic cigarette liquid.
The preparation of 6 electronic cigarette liquid of embodiment
A kind of electronic cigarette liquid mainly forms as shown in the table:
A kind of electronic cigarette liquid component list of table 4
It is prepared by the cannabinoids ingredient that industrial hemp extracts according to embodiment 2 in table 4, wherein the quality hundred of CBD
The mass percent that the mass percent that the mass percent that score is 60%, CBDV is 15%, CBG is 12%, THCV is
10%.
The electronic cigarette liquid preparation step are as follows: the cannabinoids ingredient extracted by industrial hemp is dissolved in propylene glycol and purifying
In water, a small amount of purified water dissolution Radix Glycyrrhizae, vitamin B2 and oryzanol is taken to obtain drug solution, by syrup, drug solution and Ni Bo
Tortoise beetle ester is dissolved in solvent, is sufficiently stirred, and tobacco essence is added to get electronic cigarette liquid.
The preparation of the quick-fried pearl of embodiment 7
A kind of quick-fried pearl mainly forms as shown in the table:
A kind of quick-fried pearl component list of table 5
It is prepared by the cannabinoids ingredient that industrial hemp extracts according to embodiment 1 in table 5, wherein the quality hundred of CBD
Dividing the mass percent that ratio is 65%, CBDV is 15%, and the mass percent that the mass percent of CBG is 12%, THCV is
8%.
The quick-fried pearl preparation step are as follows: mix purified water, hydroxymethyl cellulose, heating and melting, obtains shell while stirring
Material glue；The cannabinoids ingredient extracted by industrial hemp is dissolved in polyethylene glycol 400, until completely dissolved with sorbierite,
Methylparaben and tobacco essence mixing, stir evenly acquisition mixed liquor；The liquid of above-mentioned acquisition is introduced into dripping equipment and is obtained
To wet ball；Wet ball calcification, oil suction and the drying that will be obtained, obtain quick-fried pearl.
The preparation of the quick-fried pearl of embodiment 8
A kind of quick-fried pearl mainly forms as shown in the table:
A kind of quick-fried pearl component list of table 6
It is prepared by the cannabinoids ingredient that industrial hemp extracts according to embodiment 2 in table 6, wherein the quality hundred of CBD
The mass percent that the mass percent that the mass percent that score is 60%, CBDV is 15%, CBG is 12%, THCV is
10%.
The quick-fried pearl preparation step are as follows: mix purified water, povidone, heating and melting, obtains shell material glue while stirring；
The cannabinoids ingredient extracted by industrial hemp is mixed with glycerine, mannitol, ascorbic acid, tobacco essence, dimension life is added
Plain C, vitamin B2 and Radix Glycyrrhizae stir evenly acquisition mixed liquor；The liquid of above-mentioned acquisition is introduced into dripping equipment and obtains wet ball；
Wet ball calcification, oil suction and the drying that will be obtained, obtain quick-fried pearl.
The preparation of the quick-fried pearl of embodiment 9
A kind of quick-fried pearl mainly forms as shown in the table:
A kind of quick-fried pearl component list of table 7
It is prepared by the cannabinoids ingredient that industrial hemp extracts according to embodiment 2 in table 7, wherein the quality hundred of CBD
The mass percent that the mass percent that the mass percent that score is 60%, CBDV is 15%, CBG is 12%, THCV is
10%.
The quick-fried pearl preparation step are as follows: mix purified water, gelatin, heating and melting, obtains shell material glue while stirring；It will
By industrial hemp extract cannabinoids ingredient and mixed with propylene glycol, be added ethylene glycol, ascorbic acid, tobacco essence, oryzanol,
Vitamin B2 and Radix Glycyrrhizae stir evenly acquisition mixed liquor；The liquid of above-mentioned acquisition is introduced into dripping equipment and obtains wet ball；Will
Wet ball calcification, oil suction and the drying arrived, obtain quick-fried pearl.
The preparation of 10 flavoring liquid of embodiment
A kind of flavoring liquid mainly forms as shown in the table:
A kind of flavoring liquid component list of table 8
It is prepared by the cannabinoids ingredient that industrial hemp extracts according to embodiment 2 in table 8, wherein the quality hundred of CBD
The mass percent that the mass percent that the mass percent that score is 60%, CBDV is 15%, CBG is 12%, THCV is
10%.
The flavoring liquid preparation step are as follows: purified water, ethyl alcohol, polyethylene glycol 400 and mixed with propylene glycol are added by industry
The cannabinoids ingredient that hemp is extracted dissolves it sufficiently, is uniformly mixing to obtain flavoring liquid.
Embodiment 11 contains the preparation of the tobacco leaf of the cannabinoids ingredient extracted by industrial hemp
According to flavoring liquid prepared by embodiment 10, the purified water that 4 times of volumes are added is diluted, and tobacco leaf is dipped into flavoring
It in liquid, is picked up after 5h, baking is carried out at 50 DEG C and is dried to obtain the tobacco leaf containing the cannabinoids ingredient extracted by industrial hemp.
12 toxicological experiment of embodiment
6 kunming mices are taken, are randomly divided into 3 groups, are weighed, respectively experimental group, control group and blank control group.By two
It is molten after electronic cigarette liquid atomization by embodiment 4 (being 10% by the cannabinoids ingredient percent that industrial hemp extracts) preparation
Solution A is obtained in 30ml physiological saline；By the combustion fumes of two conventional cigarettes be dissolved in other 30ml physiological saline B is molten
Liquid；Placebo solution is physiological saline.Solution A, B solution and placebo solution are infused with abdominal cavity with the dosage of 0.3ml/g
The mode penetrated is injected in Mice Body.1,2,3 and 4min observes the variation of mouse after injection.
9 experimental result of table
| 1min | 2min | 3min | 4min | |
| Experimental group (solution A) | Without obvious phenomenon | Without obvious phenomenon | Without obvious phenomenon | Without obvious phenomenon |
| Control group (B solution) | Four limbs are stiff | Acutely twitch, eyes are dull | It lies prostrate motionless, still there is life | It is dead |
| Blank control | Without obvious phenomenon | Without obvious phenomenon | Without obvious phenomenon | Without obvious phenomenon |
It is obtained by analysis of experimental results: having injected two mouse appearance when 1 minute of conventional cigarette Cigarette Smoke Solution
Allergy has the phenomenon that twitch, astasia, thus it is speculated that its maincenter nerve damage.It is dead rapidly in short 4 minutes.And it infuses
The mouse of electronic cigarette liquid atomized soln and physiological saline prepared by the present invention has been penetrated then without what significant change.Illustrate the present invention
Prepared electronic cigarette liquid is without harmful components.
The additive experiment of embodiment 13
Drug addiction belongs to substance addiction, refers to that patient produces drug and physiologically relies on, such when deactivating suddenly
When drug, human or animal will appear out of strength, anxiety, salivation, vomiting, expansion pupil, expiratory dyspnea and the various painful expressions felt bad.
SPF grades of wister rats 80 are selected in this experiment, and male, weight 200-220g is randomly divided into 4 groups, every group 20.According to embodiment
The tobacco juice of 3 (being 0.01% by the cannabinoids ingredient percent that industrial hemp extracts) preparations is A tobacco juice, according to embodiment
The tobacco juice of 4 (being 10% by the cannabinoids ingredient percent that industrial hemp extracts) preparations is B tobacco juice, daily every group of rat
A tobacco juice, B tobacco juice, physiological saline and morphine, dosage are subcutaneously injected respectively are as follows: 15mg/kg observes rat after 15min is administered
State is administered once for every 2 hours, 4 times a day, after successive administration 7 days, stops administration, observes the state of rat, and record.
10 experimental result of table
Obtained by analysis of experimental results: subcutaneous injection is according to rat after embodiment 3 and the electronic cigarette liquid of the preparation of embodiment 4
State is similar to injecting normal saline, without exception, also without exception after drug withdrawal；And the rat for injecting morphine sample shows
Erect tail out, very excited, the drug abuse symptom such as do not stop to walk about shows withrawal symptom after being discontinued 1 day, have apparent additive.
Illustrate electronic cigarette liquid in the present invention containing the cannabinoids ingredient extracted by industrial hemp without additive,.
Embodiment 14 relieves fatigue experiment
ICR Healthy female mouse is taken, weight (20 ± 2) g, totally 40 experimental animals, adaptable fed are randomly divided into after 2 days
4 groups, every group 10, i.e. blank control group and 3 tested group.According to (the cannabinoids ingredient extracted by industrial hemp of embodiment 3
Mass percent is 0.01% without drug ingedient) preparation tobacco juice be A tobacco juice；It (is extracted by industrial hemp big according to embodiment 4
Numb phenols component mass percent is 10% without drug ingedient) preparation tobacco juice be B tobacco juice；According to embodiment 6 (by industrial hemp
The cannabinoids percentage composition of extraction is 9% and drug containing ingredient) preparation tobacco juice be C tobacco juice；According to embodiment 10 (by
Industrial hemp extract cannabinoids ingredient percent be 10% without drug ingedient) prepare flavoring liquid be D liquid；It is empty
White control is physiological saline.Gastric infusion is taken daily, and dosage 45mg/kg after feeding four weeks, carries out four examinations 3 times a day
It tests.
(1) after last dose 30min, the mouse of 5% weight sheet lead of root of the tail portion load mouse forced swimming: is placed in swimming
Case went swimming, the depth of water is no less than 30cm in case, water temperature (25 ± 1) DEG C, record mouse from swimming to the time of death.
(2) blood lactase acid measures: after last dose 30min, animal being placed in not swimming with a load attached to the body in the water that temperature is (25 ± 1) DEG C
Swim 10min, and adopts 20 μ l of eyeball blood measurement lactic acid content immediately after swimming.
(3) after last dose 30min, mouse serum urea nitrogen determination: is placed in not swimming with a load attached to the body in the water that temperature is 30 DEG C
Swim 90min, adopts eyeball blood 0.5ml after rest 60min, and serum diacetyl monoxime method measurement serum urea nitrogen is taken to contain after blood clotting
Amount.
(4) hepatic glycogen measures: putting to death animal after last dose 30min, takes liver, uses filter paper after physiological saline rinses
It blots in the plate being placed in ice face, weighs liver 100mg rapidly, measure hepatic glycogen content (anthrone method).
11 mouse forced swimming result of table
| Group | Original body mass (g) | Mid-term weight (g) | Swimming time (s) |
| A tobacco juice | 20.2±1.14 | 27.1±1.45 | 356.2±66.2 |
| B tobacco juice | 20.2±1.22 | 27.7±1.22 | 382.5±44.8 |
| C tobacco juice | 20.3±1.18 | 27.8±1.37 | 411.3±42.1 |
| D liquid | 20.2±0.89 | 27.3±1.97 | 383.7±42.3 |
| Blank control | 20.1±1.05 | 26.1±2.12 | 301.1±52.1 |
The results show that experimental group can be obviously prolonged mouse swimming time compared with the control group.
Influence of the table 12 to blood lactase acid, serum urea nitrogen and hepatic glycogen content
| Group | Blood lactase acid (mmol/L) | Serum urea nitrogen (mmol/L) | Hepatic glycogen (mg/100g) |
| A tobacco juice | 2.88±0.35 | 7.59±0.28 | 1497.4±135.8 |
| B tobacco juice | 2.79±0.31 | 7.58±0.22 | 1535.2±147.2 |
| C tobacco juice | 2.65±0.41 | 7.63±0.30 | 1688±132.7 |
| D liquid | 2.77±0.23 | 7.57±0.23 | 1550.8±111.9 |
| Blank control | 2.95±0.24 | 7.65±0.17 | 1335.6±157.3 |
The results show that experimental group can be substantially reduced Serum lactic acid content, and increase the content of hepatic glycogen, but to serum urea nitrogen
It has no significant effect.
In summary test result it follows that according to embodiment 3, embodiment 4 and embodiment 6 preparation electronic cigarette liquid with
And mouse fatigue can be effectively relieved in flavoring liquid prepared by embodiment 10, extend the run duration of mouse, test is proved in electronic cigarette
The fatigue conditions that the cannabinoids ingredient extracted by industrial hemp can be effectively improved animal are added in liquid, are extracted when by industrial hemp
The effect that relieves fatigue when increasing of cannabinoids component content it is more preferable, and effect is more when containing drug ingedient in tobacco juice ingredient
Significantly, mouse anti-reflecting fatigue ability is stronger.
15 sensory test of embodiment
Referring to GB 5606.4-2005 cigarette Part IV: sense organ technical requirements, aesthetic quality's standards of grading are as follows:
13 reference standard of table
Fragrance: the fragrance of the intrinsic tobacco spy tool of cigarette smoke itself.Harmony: fragrance is perfect harmony, does not feel it
In a certain monomer characteristic, if flavoring, charging and cigarette perfume reconcile, also with formula reconcile.Miscellaneous gas: do not have cigarette essence smell
, slight and apparent bad breath.Such as green grass gas gives birth to miscellaneous gas, xylon gas, withered and burnt smell, rosin gas, the miscellaneous gas of region and chokes
The breath etc. of people.Irritation: flue gas is to slight and apparent discomfort caused on sense organ.Such as to nasal cavity, oral cavity, throat
Spurt, hair spine fire burns.Pleasant impression: flue gas is after oral cavity, nasal cavity exhalation, the taste perception that carries over.Including level of comfort,
Clean level and dry sensation.
It takes out 8 professions at random to smoke panel test personnel, the age 25-45 years old, wherein 6 people of male, 2 people of women, number were that first-is pungent.It adopts
It is A tobacco juice according to electronic cigarette liquid prepared by embodiment 3 with secretly point system being commented to be tested；The electronics prepared according to embodiment 4
Tobacco juice is B tobacco juice；It is C tobacco juice according to electronic cigarette liquid prepared by embodiment 5；It is D cigarette according to electronic cigarette liquid prepared by embodiment 6
Liquid；According to quick-fried pearl prepared by embodiment 9, E cigarette will be used as in the filter tip of quick-fried pearl merging conventional cigarette；It is made according to embodiment 11
The standby tobacco containing the cannabinoids ingredient extracted by industrial hemp, it is processed that cigarette is made as F cigarette；Conventional cigarette
As control；24 Duplicate Samples of each preparation of samples, it is on probation for the personnel that smoke panel test；Personnel each smoke panel test respectively successively to above-mentioned 5
Sample is smoked panel test and gives a mark and (smoke panel test out as a result, repeating if the personnel that smoke panel test do not smoke panel test once, everyone most 3 samples)；Note
The result and statistics of each personnel that smoke panel test of record.
14 sensory test smoking result of table
Since there is no gloss to examine item for electronic cigarette, gloss item uniformly presses 5 minute marks.
It is concluded that according to smoking result statistics according to the homemade electronic cigarette liquid fragrance of the embodiment of the present invention and tradition
Cigarette is suitable；Formula hamony is more preferable, and fragrance is perfect harmony, does not feel the characteristic of wherein a certain monomer；Homemade electronic cigarette
Cigarette does not have cigarette essence smell, and bad breath is weaker；It is smaller to the excitement of nasal cavity, oral cavity, throat to make electronic cigarette liquid by oneself, does not have
There is generation sense of discomfort；Electronic cigarette flue gas is made by oneself after oral cavity, nasal cavity exhalation, the taste perception carried over is more compared with conventional cigarette
Good, level of comfort, clean level are higher.Women smoker is higher to the organoleptic requirements of cigarette, also more sensitive, aroma of pure without
The electronic cigarette of stimulation more meets the requirement of women.After adding drug ingedient in electronic cigarette liquid formula, drug can alleviate cigarette
Stimulation of the mist to smoker oral cavity, throat, the personnel that smoke panel test feel that throat is more comfortable, and irritation is smaller；It sucks and leaves down later
The taste perception come is more preferable, and miscellaneous gas is smaller；Each ingredient hamony is more preferable in formula, and fragrance is perfect harmony.
Compared with conventional cigarette, cigarette of the merging containing the quick-fried pearl of cannabinoids ingredient extracted by industrial hemp in filter tip
With with the cigarette prepared containing the tobacco leaf of cannabinoids ingredient extracted by industrial hemp to the sense organ of smoker more preferable, irritation
Smaller with miscellaneous gas, the taste perception after sucking is more preferable, and fragrance is more excellent, and each ingredient hamony is more preferable in formula.
16 comparative example of embodiment
It takes out 8 professions at random to smoke panel test personnel, the age 25-45 years old, wherein 6 people of male, 2 people of women, number were that first-is pungent.It adopts
With secretly point system being commented to be tested, (it is by the cannabinoids ingredient percent that industrial hemp extracts according to embodiment 3
0.01% without drug ingedient) preparation electronic cigarette liquid be A tobacco juice；According to embodiment 5 (by industrial hemp extract cannabinoids at
Point mass percent is 5% and has drug ingedient) electronic cigarette liquid of preparation is B tobacco juice；Compareing tobacco juice is that the prior art is existing
Electronic cigarette liquid, active constituent is only CBD, mass percent 2% in tobacco juice.24 Duplicate Samples of each preparation of samples, for commenting
Suction personnel are on probation；The personnel that each smoke panel test respectively successively smoke panel test to above-mentioned 3 samples and give a mark (if the personnel that smoke panel test do not comment once
It is sucked out as a result, repeating and smokes panel test, everyone most 3 samples)；The result and statistics of each personnel that smoke panel test of record.
15 sensory test smoking result of table
Since there is no gloss to examine item for electronic cigarette, gloss item uniformly presses 5 minute marks.
It is concluded that and the existing electronic cigarette liquid only containing CBD ingredient of the prior art according to smoking result statistics
It compares, the electronic cigarette liquid formula hamony that CBD, CBDV, CBG and THCV are prepared in proportion is more preferable, and fragrance is more perfect harmony, bad
Breath is weaker；After adding drug ingedient in electronic cigarette liquid formula, drug can alleviate smog to the thorn in smoker oral cavity, throat
Swash, the personnel that smoke panel test feel that throat is more comfortable, and irritation is smaller, and the taste perception carried over after sucking is more preferable, and miscellaneous gas is more
It is small；And the personnel that smoke panel test unanimously think, compared with compareing tobacco juice, spiritual happiness after being inhaled according to the tobacco juice of preparation of the embodiment of the present invention
Feel stronger.
Claims (15)
1. a kind of composition for tobacco product, the composition includes the cannabinoids ingredient extracted by industrial hemp and auxiliary
Expect, the mass percent of the cannabinoids ingredient extracted in the composition by industrial hemp is 0.01-10%, described by industry
Contain CBD and CBDV in the cannabinoids ingredient that hemp is extracted, CBD in the cannabinoids ingredient extracted by industrial hemp
Mass percent is 30-90%, and the mass percent of CBDV is 1-25%.
2. composition according to claim 1, which is characterized in that the cannabinoids ingredient extracted by industrial hemp
In also contain CBG and/or THCV, it is described by industrial hemp extract cannabinoids ingredient in CBG mass percent be 1-
25%, THCV mass percent are 0.1-20%.
3. composition according to claim 1, the cannabinoids ingredient is industrial hemp extract, the industry
Cannador combines after extracting each hemp phenols component respectively, or extracts obtain mentioning containing each hemp phenols component simultaneously
Take object.
4. composition according to claim 1 to 4, which is characterized in that the composition be electronic cigarette liquid, quick-fried pearl or
Flavoring liquid.
5. composition according to claim 5, which is characterized in that the composition is electronic cigarette liquid, the electronic cigarette liquid
Including the cannabinoids ingredient extracted by industrial hemp and solvent, by the cannabinoids of industrial hemp extraction in the electronic cigarette liquid
The mass percent of ingredient is 0.01-10%, contains CBD and CBDV in the cannabinoids ingredient extracted by industrial hemp,
The mass percent of CBD is 30-90% in the cannabinoids ingredient extracted by industrial hemp, and the mass percent of CBDV is
1-25%.
6. composition according to claim 5, which is characterized in that the composition is flavoring liquid, and the flavoring liquid includes
The cannabinoids ingredient and solvent extracted by industrial hemp, the cannabinoids ingredient extracted by industrial hemp in the flavoring liquid
Mass percent is 0.01-10%, it is described by industrial hemp extract cannabinoids ingredient in contain CBD and CBDV, it is described by
The mass percent of CBD is 30-90% in the cannabinoids ingredient that industrial hemp extracts, and the mass percent of CBDV is 1-
25%.
7. composition according to claim 6 or 7, which is characterized in that also contain by mass percentage in the composition
The group of one or more of stabilizer 0-12%, preservative 0-1%, tobacco essence 0-5%, drug ingedient 0-15%
It closes.
8. composition according to claim 6 or 7, which is characterized in that the solvent is selected from: glycerine, propylene glycol, poly- second
The combination of one or more of glycol, diethylene glycol (DEG), triethylene glycol, ethyl alcohol, purified water, the quality of solvent in the composition
Percentage is 57-99.99%.
9. composition according to claim 5, which is characterized in that the composition is quick-fried pearl, and quick-fried pearl includes by industrial big
Cannabinoids ingredient, solvent and the adhesive that fiber crops are extracted, the matter of the cannabinoids ingredient extracted by industrial hemp in the quick-fried pearl
Amount percentage is 0.01-10%, and CBD and CBDV is contained in the cannabinoids ingredient extracted by industrial hemp, described by work
The mass percent of CBD is 30-90% in the cannabinoids ingredient that sparetime university fiber crops are extracted, and the mass percent of CBDV is 1-25%.
10. composition according to claim 10, which is characterized in that the solvent is selected from: glycerine, propylene glycol, poly- second
The combination of one or more of glycol, diethylene glycol (DEG), triethylene glycol, ethyl alcohol, purified water, the quality hundred of solvent in the quick-fried pearl
Divide than being 40-60%.
11. composition according to claim 10, which is characterized in that described adhesive is selected from: hydroxypropyl cellulose, hydroxyl first
Base cellulose, hydroxyethyl cellulose, ethyl cellulose, hydroxypropyl methyl cellulose, microcrystalline cellulose, starch, superfine silica gel powder, shallow lake
Slurry, maltose, refined honey, polyvinylpyrrolidone, povidone, liquid glucose, cellulose derivative, sodium alginate, is gathered syrup
The combination of one or more of ethylene glycol, aluminum magnesium silicate, gelatin, tragacanth, the quality of adhesive in the quick-fried pearl
Percentage is 30-50%.
12. any composition of 0-12 according to claim 1, which is characterized in that in the quick-fried pearl by mass percentage also
Contain one or more of plasticizer 0-5%, preservative 0-1%, tobacco essence 0-5%, drug ingedient 0-15%
Combination.
13. a tobacco articles, which is characterized in that the tobacco product include by industrial hemp extract cannabinoids ingredient and
Tobacco leaf, the mass percent of the cannabinoids ingredient extracted in the tobacco product by industrial hemp are 0.01-1%, it is described by
Industrial hemp extract cannabinoids ingredient in contain CBD and CBDV, it is described by industrial hemp extract cannabinoids ingredient in
The mass percent of CBD is 30-90%, and the mass percent of CBDV is 1-25%.
14. tobacco product described in claim 14, which is characterized in that the cannabinoids ingredient extracted by industrial hemp
In also contain CBG and/or THCV, it is described by industrial hemp extract cannabinoids ingredient in CBG mass percent be 1-
25%, THCV mass percent are 0.1-20%.
15. tobacco product according to claim 14 or 15, which is characterized in that the preparation method packet of the tobacco product
It includes: preparing flavoring liquid as claimed in claim 7, tobacco leaf is dipped among flavoring liquid as claimed in claim 7, stand, it is dry
It obtains, or the spray of flavoring liquid is added on tobacco leaf, be dried to obtain.
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| CN110638082A (en) * | 2019-10-28 | 2020-01-03 | 武汉红金叶新材料科技有限公司 | Formulation suitable for heating non-combustion tobacco and preparation process thereof |
| CN112064406A (en) * | 2020-09-07 | 2020-12-11 | 云南中烟工业有限责任公司 | Special aroma forming paper prepared from jatropha roots of Dai nationality traditional edible spice plants of Xishuangbanna, method and application thereof |
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| WO2022077216A1 (en) * | 2020-10-13 | 2022-04-21 | 深圳市舜宝科技有限公司 | Composition, preparation method and cartridge |
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| CN110200953A (en) * | 2019-06-15 | 2019-09-06 | 汉义生物科技（北京）有限公司 | Cannboid is preparing the application in inhalation drug |
| CN110638082A (en) * | 2019-10-28 | 2020-01-03 | 武汉红金叶新材料科技有限公司 | Formulation suitable for heating non-combustion tobacco and preparation process thereof |
| JP7578936B2 (en) | 2020-07-08 | 2024-11-07 | 株式会社ワンインチ | Liquid composition for electronic cigarettes and electronic cigarettes having the same |
| CN112064406A (en) * | 2020-09-07 | 2020-12-11 | 云南中烟工业有限责任公司 | Special aroma forming paper prepared from jatropha roots of Dai nationality traditional edible spice plants of Xishuangbanna, method and application thereof |
| WO2022077217A1 (en) * | 2020-10-13 | 2022-04-21 | 深圳市舜宝科技有限公司 | Composition, preparation method and tea cartridge |
| WO2022077216A1 (en) * | 2020-10-13 | 2022-04-21 | 深圳市舜宝科技有限公司 | Composition, preparation method and cartridge |
| IT202100021824A1 (en) * | 2021-08-12 | 2023-02-12 | E Liquid Labs S R L | Flavored liquid formulation for electronic cigarette |
| CN114539199A (en) * | 2022-02-18 | 2022-05-27 | 云南工麻生物科技有限公司 | Cannabinol derivative compounds and preparation method thereof |
| CN115385780A (en) * | 2022-08-26 | 2022-11-25 | 晨光生物科技集团股份有限公司 | Sub-cannabidiol crystal polymorphic substance as well as preparation method and application thereof |
| CN115385780B (en) * | 2022-08-26 | 2024-02-27 | 晨光生物科技集团股份有限公司 | Secondary cannabidiol crystal polymorph and preparation method and application thereof |
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