CN114984121A - Aromatic brain-refreshing and anti-fatigue traditional Chinese medicine composition as well as preparation method and application thereof - Google Patents
Aromatic brain-refreshing and anti-fatigue traditional Chinese medicine composition as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses an aromatic refreshing and anti-fatigue traditional Chinese medicine composition which comprises the following raw materials in parts by weight: 2-9 parts of storax, 2-9 parts of rhizoma acori graminei, 1-6 parts of dalbergia wood and 1-6 parts of nardostachyos root and rhizome. The traditional Chinese medicine composition provided by the invention can effectively reduce the sleep onset rate, prolong the sleep latency and shorten the sleep duration, and has the functions of refreshing mind and resisting fatigue.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition with fragrance, refreshment and fatigue resistance, and a preparation method and application thereof.
Background
In modern society, with the increase of living pressure, students and office workers are easy to fatigue and sleepy due to overlong mental labor time, and have poor consequences such as unclear thinking, disordered thinking, low working efficiency and the like. People usually refresh by drinking drinks such as coffee, strong tea and the like, but the drinks are easy to cause dependence and can cause adverse symptoms such as insomnia and the like. Under such circumstances, researchers have tried aromatic Chinese medicines to achieve the effects of refreshing mind and relieving fatigue. Aromatherapy is a natural therapy which takes aromatic plants to form single-component or compound volatile oil through extraction as a medium, and acts on local or whole body in the modes of sniffing, massaging, oral administration, fumigating and the like on the premise of safety so as to achieve the effects of conditioning skin, balancing emotion, preserving health and protecting health.
Although various health care products or medicines for refreshing and restoring consciousness and eliminating fatigue sold in the market at present can play a role of temporary refreshing, the fatigue cannot be eliminated fundamentally, the effect is slow, and a good refreshing effect cannot be obtained; in addition, in the prior art, few researches on the application of aromatic traditional Chinese medicines in refreshing and eliminating fatigue are carried out.
Disclosure of Invention
In view of the above technical problems, the present invention provides the following technical solutions:
the invention provides a traditional Chinese medicine composition with fragrance, refreshment and fatigue resistance, which comprises the following raw materials in parts by weight: 2-9 parts of storax, 2-9 parts of rhizoma acori graminei, 1-6 parts of dalbergia wood and 1-6 parts of nardostachyos root and rhizome.
Preferably, the feed additive comprises the following raw materials in parts by weight: 2 parts of storax, 2 parts of rhizoma acori graminei, 1 part of rosewood heart wood and 1 part of nardostachyos root and rhizome.
Preferably, the feed additive comprises the following raw materials in parts by weight: 2 parts of storax, 3 parts of rhizoma acori graminei, 2 parts of dalbergia wood and 2 parts of nard.
Preferably, the composition consists of the following raw materials in parts by weight: 3 parts of storax, 3 parts of grassleaf sweelflag rhizome, 2 parts of rosewood heart wood and 2 parts of nard.
The invention also provides a preparation method of the aromatic brain-refreshing and fatigue-resisting traditional Chinese medicine composition, which comprises the following steps: weighing storax, rhizoma Acori Graminei, lignum Dalbergiae Odoriferae and rhizoma Nardostachyos according to weight parts, mixing, and extracting volatile oil.
Preferably, the extraction is by steam distillation, low-polarity organic solvent extraction, carbon dioxide fluid extraction or supercritical CO 2 And (3) one of the extractions.
Preferably, the supercritical CO 2 The specific process parameters of the extraction are set as follows: the extraction temperature is 35-60 ℃, the extraction pressure is 30-35MPa, the extraction time is 180min, and the entrainer dosage is 10%.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicament for refreshing.
The invention also provides a traditional Chinese medicine preparation with fragrance, refreshment and fatigue resistance, which comprises the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials or carriers.
Preferably, the traditional Chinese medicine preparation is aerosol, nasal spray or nasal suppository.
The traditional Chinese medicine composition with the functions of refreshing mind and resisting fatigue, provided by the invention, has the advantages that storax and rhizoma acori graminei are aromatic and pungent in flavor and warm in nature, are products for resuscitation, dirt removal and refreshing, have strong power of fragrance and dispersion, have the effects of refreshing mind and strengthening brain, eliminating dampness and harmonizing stomach, and calming the mind and benefiting the mind, and are monarch medicines in the formula; dalbergia wood has the efficacy of 'moving fragrance and guiding medicine upwards', and nard can prevent the warm and dryness of the prodrug from being too much, has the functions of tonifying, harmonizing and relieving, and is used as an adjuvant and guiding medicine together. The medicines are combined to play the effects of avoiding the dirty and preventing the infection, and inducing resuscitation and restoring consciousness.
Compared with the prior art, the invention has the beneficial effects that:
1. the traditional Chinese medicine composition provided by the invention comprises the raw materials containing volatile oil components such as storax, rhizoma acori graminei, dalbergia wood, nardostachyos and the like, and can effectively reduce the sleep onset rate, prolong the sleep latency and shorten the sleep duration after being matched with a specific dosage, and has the effects of fragrance, consciousness restoring and fatigue resisting.
2. The traditional Chinese medicine composition provided by the invention has the characteristics of no toxicity and long-term use, develops a new field for clinical application of new medicinal or health-care functions of aromatic traditional Chinese medicine combination, and has wide market prospect.
Detailed Description
The invention provides a traditional Chinese medicine composition and application thereof in preparing a medicament for refreshing, and a person skilled in the art can refer to the contents and appropriately improve process parameters for realization. It is expressly intended that all such similar substitutes and modifications which would be obvious to one skilled in the art are deemed to be included in the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of skill in the art that variations and modifications in the methods and applications disclosed herein, or appropriate variations and combinations thereof, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.
The invention provides a traditional Chinese medicine composition with fragrance, refreshment and fatigue resistance, which comprises the following raw materials in parts by weight: 2-9 parts of storax, 2-9 parts of rhizoma acori graminei, 1-6 parts of dalbergia wood and 1-6 parts of nardostachyos root and rhizome.
The storax, the grassleaf sweelflag rhizome, the rosewood heart wood and the nardostachys chinensis are aromatic medicines, and the aromatic medicines are small in molecules, can easily penetrate through a blood brain barrier, and meanwhile, the permeability of the blood brain barrier is increased, so that other medicines are promoted to be accumulated in the brain after passing through the blood brain barrier. Research shows that the aromatic resuscitation inducing medicine can open the blood brain barrier by changing the ultrastructure of the blood brain barrier and influencing the function of P-glycoprotein; or regulating the content of certain neurotransmitters such as dopamine and 5-hydroxytryptamine to influence nerve impulse; or the concentration of the aromatic medicine has double functions of excitation or inhibition on the center, thereby realizing the effect of inducing resuscitation and restoring consciousness.
The invention will be further elucidated with reference to the following examples:
example 1
A traditional Chinese medicine composition with fragrance, refreshment and fatigue resistance is composed of the following raw materials in parts by weight: 3 parts of storax, 3 parts of grassleaf sweelflag rhizome, 2 parts of rosewood heart wood and 2 parts of nardostachyos root and rhizome.
The composition is prepared by the following method:
weighing storax, rhizoma Acori Graminei, lignum Dalbergiae Odoriferae and rhizoma Nardostachyos according to formula, drying, pulverizing, sieving, weighing, charging, supercritical CO2 extracting (extraction conditions including extraction temperature 55 deg.C, extraction pressure 30MPa, extraction time 120min, entrainer amount 10%), and separating under reduced pressure to obtain volatile oil.
Example 2
A traditional Chinese medicine composition with fragrance, refreshment and fatigue resistance is composed of the following raw materials in parts by weight: 2 parts of storax, 2 parts of rhizoma acori graminei, 1 part of dalbergia wood and 1 part of nard.
The preparation method is the same as example 1.
Example 3
A traditional Chinese medicine composition with fragrance, refreshment and fatigue resistance is composed of the following raw materials in parts by weight: 3 parts of storax, 2 parts of rhizoma acori graminei, 2 parts of dalbergia wood and 2 parts of nard.
The preparation method is the same as example 1.
Example 4
A traditional Chinese medicine composition with fragrance, refreshment and fatigue resistance is composed of the following raw materials in parts by weight: 2 parts of storax, 3 parts of rhizoma acori graminei, 2 parts of dalbergia wood and 2 parts of nard.
The preparation method is the same as example 1.
Example 5
A traditional Chinese medicine composition with fragrance, refreshment and fatigue resistance is composed of the following raw materials in parts by weight: 9 parts of storax, 9 parts of rhizoma acori graminei, 6 parts of dalbergia wood and 6 parts of nardostachyos.
The preparation method is the same as example 1.
Comparative example 1
A traditional Chinese medicine composition with fragrance, refreshment and fatigue resistance is composed of the following raw materials in parts by weight: 3 parts of storax, 2 parts of rosewood heart wood and 2 parts of nardostachys chinensis.
The preparation method is the same as example 1.
Comparative example 2
A traditional Chinese medicine composition with fragrance, refreshment and fatigue resistance is composed of the following raw materials in parts by weight: 3 parts of grassleaf sweelflag rhizome, 2 parts of rosewood heart wood and 2 parts of nardostachys root.
The preparation method is the same as example 1.
Experimental example 1
Allergy test
Whether the animal respiratory system is stimulated or not is researched, so that a guinea pig is used as an experimental animal, the guinea pig has developed smell and is easy to be allergic, the guinea pig is commonly used for researching drug allergy and antiasthmatic drugs, and the allergic symptoms of the guinea pig are divided into five grades:
the guinea pig has no symptoms and shows normal performance, the symptoms are marked as the allergic intensity < - >, the score is 0, and the allergic reaction is judged to be negative;
the guinea pig has symptoms of restlessness, hair erection, trembling and nasal pruritus, and is marked as the allergic intensity "+", the score is "1", and the allergic reaction is judged as "weak positive";
the guinea pig has symptoms of sneezing, cough, shortness of breath, urination, defecation and lacrimation, and is marked as allergic intensity "+", score "2", and the allergic reaction is judged as "positive";
the guinea pig has symptoms of dyspnea, wheezing, purpura, gait instability, jumping, wheezing, spasm, rotation and tidal breathing, which are marked as allergic strength +++, and score of 3, and the allergic reaction is judged as strong positive;
guinea pigs died and scored as allergic intensity ++++, scoring "4", and allergic reactions were judged as "very positive".
Each group of guinea pigs (8 per group) were administered with the Chinese medicinal compositions of examples 1-5 and comparative examples 1-2, and were taken out after 15min, and the state 15min before and 15min after spraying was recorded, the plastic box was washed, the above procedure was repeated after the odor in the box disappeared, and pure water was used as a normal control group. The above steps were repeated every other day, and the experiment was repeated 3 times.
The results of the manifestation of allergic symptoms in the guinea pigs of each group are shown in Table 1.
TABLE 1 allergic Strength in the groups of Guinea pigs
Experimental example 2
Randomly selecting 8 groups of healthy mice (8 mice per group), placing in a transparent plastic box filled with the aerosol of the formula for 15min, taking out, placing in air for 15min, and continuously administering for 7 days for 1 time per day. After 30min of the last administration, pentobarbital sodium (50mg/kg) was administered, the sleep latency and sleep time were measured using the incidence of the positive reflex (i.e., the rate of falling asleep) as an index, and pure water was used as a normal control group.
The results are shown in Table 2.
TABLE 2 Effect of groups on sleep time of pentobarbital mice
Note: and the sodium salt of pentobarbital, Δ p is less than 0.05; in comparison with comparative example 1, # p is less than 0.05; in comparison with the comparative example 2, * P＜0.05。
the above results illustrate that: the traditional Chinese medicine composition provided by each embodiment group has an obvious refreshing function, and compared with a test medicine lacking part of components (namely each comparative example group), the traditional Chinese medicine composition provided by each embodiment group can remarkably reduce the falling asleep rate and shorten the sleep duration. The components in the examples play a very important role in the exertion of the effect, and the components are absent, so that the synergistic effect is realized.
The above disclosure is only for the specific embodiments of the present invention, but the embodiments of the present invention are not limited thereto, and any variations that can be considered by those skilled in the art should fall within the scope of the present invention.
Claims (10)
1. The aromatic brain-refreshing and fatigue-resisting traditional Chinese medicine composition is characterized by comprising the following raw materials in parts by weight: 2-9 parts of storax, 2-9 parts of rhizoma acori graminei, 1-6 parts of dalbergia wood and 1-6 parts of nardostachyos root and rhizome.
2. The aromatic brain-refreshing and fatigue-resisting traditional Chinese medicine composition according to claim 1 is characterized by comprising the following raw materials in parts by weight: 2 parts of storax, 2 parts of rhizoma acori graminei, 1 part of dalbergia wood and 1 part of nard.
3. The aromatic brain-refreshing and fatigue-resisting traditional Chinese medicine composition according to claim 1 is characterized by comprising the following raw materials in parts by weight: 2 parts of storax, 3 parts of rhizoma acori graminei, 2 parts of dalbergia wood and 2 parts of nard.
4. The aromatic brain-refreshing and fatigue-resisting traditional Chinese medicine composition according to claim 1 is characterized by comprising the following raw materials in parts by weight: 3 parts of storax, 3 parts of grassleaf sweelflag rhizome, 2 parts of rosewood heart wood and 2 parts of nardostachyos root and rhizome.
5. A method for preparing the aromatic refreshing and fatigue resisting traditional Chinese medicine composition as claimed in any one of claims 1 to 4, which is characterized by comprising the following steps: weighing storax, rhizoma Acori Graminei, lignum Dalbergiae Odoriferae, and rhizoma Nardostachyos in parts by weight, mixing, and extracting volatile oil to obtain the final product.
6. The method for preparing a Chinese medicinal composition with refreshing and anti-fatigue effects according to claim 5, wherein the extraction is performed by steam distillation, low-polarity organic solvent extraction, carbon dioxide fluid extraction or supercritical CO 2 And (3) one of the extractions.
7. The method for preparing the aromatic brain-refreshing and fatigue-resisting traditional Chinese medicine composition according to claim 6, wherein the supercritical CO is 2 The specific process parameters of the extraction are set as follows: the extraction temperature is 35-60 ℃, the extraction pressure is 30-35MPa, the extraction time is 180min, and the dosage of the entrainer is 10%.
8. Use of a Chinese medicinal composition according to any one of claims 1 to 4 in the preparation of a medicament for refreshing the mind.
9. A Chinese medicinal preparation with fragrance for refreshing brain and relieving fatigue, which comprises the Chinese medicinal composition of any one of claims 1-4, and pharmaceutically acceptable adjuvants or carriers.
10. The aromatic brain-refreshing and fatigue-resisting traditional Chinese medicine preparation according to claim 9, which is an aerosol, a nasal spray or a nasal suppository.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547868A (en) * | 2015-01-22 | 2015-04-29 | 永春县达埔联发香业有限公司 | Medicine or health product composition for inducing resuscitation for resuscitation as well as preparation method and application of medicine or health product composition |
| WO2018086501A1 (en) * | 2016-11-10 | 2018-05-17 | 罗时富 | Novel ironing moxibustion apparatus combining moxibustion and ironing methods and manufacturing method therefor |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547868A (en) * | 2015-01-22 | 2015-04-29 | 永春县达埔联发香业有限公司 | Medicine or health product composition for inducing resuscitation for resuscitation as well as preparation method and application of medicine or health product composition |
| WO2018086501A1 (en) * | 2016-11-10 | 2018-05-17 | 罗时富 | Novel ironing moxibustion apparatus combining moxibustion and ironing methods and manufacturing method therefor |
Non-Patent Citations (2)
| Title |
|---|
| LI SS ET.AL: "EFFECT OF TAO-HONG-SI-WU-TANG, A TRADITIONAL CHINESE HERBAL MEDICINE FORMULA, ON PHYSICAL FATIGUE IN MICE", 《AFR J TRADIT COMPLEMENT ALTERN MED》 * |
| 左珂等: "芳香疗法治疗失眠研究进展", 《实用中医药杂志》 * |
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