CN103933150B - A kind of have the health care oral liquid changing sleep quality effect - Google Patents

Abstract

The invention discloses a kind of health care oral liquid with change sleep quality effect, for raw material with 2 ~ 6 portions of Ganodermas, 1 ~ 3 part of Flos Chrysanthemi, 4 ~ 8 portions of Fructus Jujubaes, 2 ~ 4 parts of Semen Ziziphi Spinosaes, 2 ~ 3 parts of Mel, prepare through water extraction, ethanol extraction etc., products obtained therefrom Fructus Jujubae sweet in the mouth is sweet, slightly there is bitter sense, pure good to eat, liquid is clear and bright bright.Oral liquid of the present invention has tranquilizing by nourishing the heart, blood yiqi, settling five organs, and protect god, hard muscles and bones, the effects such as good color are a kind of calm catalyst formulations, can effective improving water flood quality.

Description

A kind of have the health care oral liquid changing sleep quality effect

Technical field

The present invention relates to and a kind of there is health care oral liquid changing sleep quality effect and preparation method thereof.

Background technology

Sleep is a kind of spontaneous and reversible quiescent condition that higher vertebrate periodically occurs, the brief interruption that the reactivity that showing as body stimulates to external world reduces and realizes.The time in all one's life nearly 1/3 of people is spent in sleep.When people are in sleep state, the brain of people and health can be made to obtain having a rest, rest and reorganize and recovering.Contribute to the working and learning that people are daily.Science improves sleep quality, is the guarantee of the normal work and study life of people.

Sleep disorder is one of puzzlement common complaint among the elderly disease.Due to the normal aging of old people's body and the day by day decline of brain function, the change of nervous system structures and function, as neuronic disappearance and decrease of synapses etc., sleep cycle rhythm and pace of moving things function is affected, and causes sleep regulation function reduction.Awakening suffers damage with the adjustment of sleep rhythm, thus lacks deep sleep and fast wave sleep, and sleeping state increases relatively.According to statistics, in the old people of over-65s, the people of 35 ~ 50% is had often to be subject to the puzzlement of sleep disorder.Sleep disorder can increase the weight of existing organic disease, weakens therapeutic effect.Produce dysphoria due to sleep disorder, feel exhausted, impatient, anxiety, depressedly waits disease, affect stablizing of cardiovascular and cerebrovascular vessel and other organ functions further, easily causes cardiac arrhythmia, coronary heart disease, the diseases such as cerebrovascular.Extended sleep is not enough, and memory cell cannot healthy living, easily makes a mistake, such as aphasia, spasm, tic, or the shock that causes of mandatory dormancy and faintness, easy generation canceration of a specified duration.

Melatonin is one of effective health product of improving water flood quality.Its main component is melatonin, and with age, pinus degeneration calcification, human body melatonin reduces and impact sleep.Edible melatonin directly increases human body melatonin and also just improves sleep.But with advancing age, human organ and the aging principal element being sleep disorder and producing of brain 26S Proteasome Structure and Function.Improve cardiovascular and cerebrovascular vessel and make its normal operation, regulate excited and suppress, by edible calmness, catalytic action prescription, improving water flood and the awakening rhythm and pace of moving things are the another kind of method and access improving sleep quality.

Summary of the invention

For above-mentioned prior art, the invention provides a kind of health care oral liquid with change sleep quality effect.

The present invention is achieved by the following technical solutions:

There is the health care oral liquid changing sleep quality effect, be with 2 ~ 6 portions of Ganodermas, 1 ~ 3 part of Flos Chrysanthemi, 4 ~ 8 portions of Fructus Jujubaes, 2 ~ 4 parts of Semen Ziziphi Spinosaes, 2 ~ 3 parts of Mel for raw material (by weight), prepare through following methods:

(1) Ganoderma, Flos Chrysanthemi and Fructus Jujubae is got, adding temperature is in the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour (in immersion process can agitation as appropriate), filter, obtain filtrate and filtering residue, the water that temperature is 95 ~ 98 DEG C is added again in filtering residue, soak 0.5 hour, filter, repeat this process 1 ~ 3 time (preferably 3 times), extract altogether 2 ~ 4 times (preferably 4 times), the quality of the water at every turn added is 8 ~ 12 times (preferably 10 times) of three's gross weight (Ganoderma, Flos Chrysanthemi and Fructus Jujubae); Merging filtrate, concentrated (being preferably concentrated into 1/2 of three's gross weight), obtains paste;

Further, Ganoderma is cut into the fritter of 0.3 ~ 0.4cm, Fructus Jujubae is cut into the fritter that thickness is 0.2 ~ 0.4cm;

(2) Semen Ziziphi Spinosae is got, pulverize or smash (smash to largest block be the fritter of 0.3cm), add the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour (in immersion process can agitation as appropriate), filter, obtain filtrate and filtering residue, the water of 95 ~ 98 DEG C is added again in filtering residue, soak 0.5 hour, filter, repeat this process 1 ~ 3 time (preferably 3 times), extract altogether 2 ~ 4 times (preferably 4 times), the quality of the water at every turn added is 8 ~ 12 times (preferably 10 times) of Semen Ziziphi Spinosae weight; Merging filtrate, concentrated (being preferably concentrated into 1/2 of Semen Ziziphi Spinosae weight), obtains Semen Ziziphi Spinosae paste;

5 times of (quality volume multiples are added in Semen Ziziphi Spinosae paste, namely 1 gram of Semen Ziziphi Spinosae paste adds 5ml) 95 ~ 100% (percentage by volume) alcoholic solution (when percentage by volume is 100%, for dehydrated alcohol), soak extraction 0.5 hour (in immersion process can agitation as appropriate); Then, at-10 ~-26 DEG C freezing 40 ~ 60 minutes, removing precipitation is taken out, supernatant concentration, to 1/3 of original volume, then at-10 ~-26 DEG C freezing 40 ~ 60 minutes, takes out removing precipitation, supernatant concentration (being preferably concentrated into 1/3 of Semen Ziziphi Spinosae weight), obtains Semen Ziziphi Spinosae extract;

(3) step (1) gained paste is mixed with step (2) gained Semen Ziziphi Spinosae extract, obtain mixture, add Mel, mixing, obtains mixed liquor, adds suitable quantity of water (water of preferred mixed liquor 5 times of weight) and dissolves, filter, the health care oral liquid changing sleep quality effect must be had, 100 DEG C of boiling water sterilizings 1 hour, canned 50ml/ bottle.Product Fructus Jujubae sweet in the mouth is sweet, and slightly have bitter sense, pure good to eat, liquid is clear and bright bright, places 18 months without any precipitation.

Of the present invention have the health care oral liquid changing sleep quality effect, raw materials used as follows:

Semen Ziziphi Spinosae: be the seed of Rhamnaceae machaka or dungarunga plant Ziziphi Spinosae ZiziphusjujubaMill.var.spinosa (Bunge) HuexH.F.Chou..

Fructus Jujubae: be the mature fruit of Rhamnaceae deciduous tree plant Fructus Jujubae ZiziphusjujubaMill..

Ganoderma: be Ganoderma Ganodermalucidum (Leyss.exFr.) Karst. (having another name called Ganoderma lucidum (Leyss. Ex Fr.) Karst.) of Polyporaceae Ganoderma fungus and the sporophore of Ganoderma Ganodermajaponicum (Fr.) Lloyd. (having another name called wooden sesame " herbal classic ").

Flos Chrysanthemi: be the head inflorescence of Compositae herbaceos perennial chrysanthemum ChrysanthemummorifoliumRamat..

Of the present invention have the health care oral liquid changing sleep quality effect, and raw materials used pharmacological action is as follows:

Ganoderma: sweet, flat." herbal classic ": " sweet, temperature.Have and nourish strong effect ".Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, hypertension, coronary heart disease, hepatitis, rheumatic arthritis, pneumosilicosis; " herbal classic ": " god, beneficial vital essence are protected, hard muscles and bones, good color in main deafness, sharp joint ".Compendium of Material Medica: " treatment asthenia "." illustrated handbook planted by middle traditional Chinese medicines ": " controlling neurasthenia, insomnia, the chronic diseases such as dyspepsia "." diet regimen complete solution ": " Ganoderma sinense Zhao Xu et Zhang contains ergosterol, organic acid, glucosamine, polysaccharide, resin, mannitol etc.Ganoderma lucidum (Leyss. Ex Fr.) Karst. is containing ergosterol, resin, fatty acid, mannitol and polysaccharide; Again containing alkaloid, lactone, coumarin, water soluble protein and multiple enzyme.In recent years clinical observation, clinical have the effect improving immune function to some immunological diseases." modern Compendium of Materia Medica " (upper volume): " impact on nervus centralis: Ganoderma constant temperature percolate (60 DEG C of water logging 24h; make with ethanol deproteinization) has inhibitory action (5; 10g/kg, ip) to central nervous system of mice, shows as movable minimizing; Muscle slightly relaxes, and extends hexobarbital sleeping time "." Ganoderma has analgesia, cough-relieving, phlegm-dispelling functions, improves mice hypoxia-bearing capability "." Ganoderma mycelium extract obviously can promote that Turnover of Mouse Peritoneal Macrophages gulps down drink rate and lysosomal enzyme activities ".

Fructus Jujubae: sweet, temperature.Enter spleen, stomach warp.There is invigorating the spleen and replenishing QI, effect of nourishing blood to tranquillize the mind.Cure mainly weakness of the spleen and stomach, incessant chronic diarrhea, insufficiency of the spleen edema, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation etc." herbal classic ": " regulating the spleen and stomach supports spleen, helps 12 warps ... mend weak breath, few body fluid, not enough, frightened in body, heaviness of limbs, and hundred medicines "." medication on the analogy of natural things ": " adjust battalion to defend, born fluid." " not Lu ": " and invigorating the spleen and replenishing QI, powerful, except unhappy ... "." Treatise on Dietetic Therapy ": " main body fluid complementing, washes trusted subordinate's pathogen, and hundred poison of drug, logical nine orifices, tonifying for the deficiency gas ... "." Japan hanako materia medica ": " profit cardiopulmonary, antitussive "." medicineization justice ": " nourish blood tonifying liver "." book on Chinese herbal medicine is new again ": " invigorating the spleen and replenishing QI, nourishing kidney warming the stomach, controls the deficiency of YIN ".Li Shizhen (1518-1593 A.D.) " detailed outline ": " " Plain Questions " say Fructus Jujubae be spleen fruit, the splenopathy should eat it, for curing the disease and medicine, Fructus Jujubae be spleen channel blood system medicine also ".Shen Lilong " food book on Chinese herbal medicine can be compiled ": " take light ear for a long time to prolong life, invigorating the spleen and replenishing QI, hard will, powerful, except unhappy, profit cardiopulmonary, antitussive, tonifying five ZANG-organs ... ".Fructus Jujubae contains protein, saccharide, organic acid, phlegmatic temperament, vitamin C, P, micro-calcium, phosphorus, ferrum and several amino acids etc.Be improved the function of eating of monokaryon in body-cell system of eating.The liver protecting, muscle strength reinforcing and the effect such as to put on weight.

Flos Chrysanthemi: pungent, sweet, bitter, cool.Return lung, Liver Channel.There is loose wind heat clearing away, dry liver improving eyesight, effect of removing toxic substances blood pressure lowering.Cure mainly anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted waits disease." herbal classic ": " main all dizziness due to wind, swell and ache, and order wish is de-, lacrimation, the dead flesh of skin, aversion to wind arthralgia chiefly caused by damp pathogen, sharp vim and vigour "." not Lu ": " treating lumbago goes happy, except irritable feverish sensation in the chest, and peace the intestines and stomach, sharp five pulse conditions of ZANG-organs, adjusts extremity "." property of medicine opinion ": " can control hot head's wind to revolve and fall down to the ground, brain bone pain, all wind orders are with it dissipated ".TAO Hong-Jing: " Flos Chrysanthemi, main air is dizzy "." medication heart method ": " removing nebula film, improving eyesight "." Japan hanako materia medica ": " control extremity urticaria, vexed, chest and diaphragm is stopped up vexed, and pain poison, headache; Do pillow improving eyesight "." detailed outline is picked up any lost article from the road ": " specially enter sun point, control all dizziness due to wind, alcoholic intoxication is treated swollen "." yellow tea chrysanthemum, improving eyesight is dispeled the wind, and searches irritability, controls and has a dizzy spell.Benefit blood profit is held, and enters blood system.Ramulus et Folium Mussaendae Pubescentis chrysanthemum: logical lung qi.Cough-relieving is inverse, clear three burnt stagnated fire, treats flesh heat and enters edema caused by disorder of QI ".Wang Haogu: " main deficiency of liver-QI "." Xinhua's book on Chinese herbal medicine outline ": " for affection due to external wind and heat, conjunctival congestion and swelling pain, conjunctivitis, pharyngolaryngitis, mastitis, carbuncle skin ulcer furuncle, hypertension "." book on Chinese herbal medicine is just read ": " suppressing the hyperactive liver dredges lung, the pathogenic heat of the clear part of the body cavity above the diaphragm housing the heart and lungs, controls order and dispels the wind, tonifying YIN nourishing kidney ".Flos Chrysanthemi, containing volatile oil, is Borneolum Syntheticum, Camphora, chrysanthenone etc. in oil, in addition still containing chrysanthemum glycoside, adenine, choline, stachydrine, and vitamin A, B etc.The water logging agent of 1:1 ~ 1:5 or decoct are to staphylococcus aureus, and multiple pathogenic bacillus and dermatophytes all have certain antibacterial action; During high concentration, infected by influenza PR3 and leptospira have inhibitory action, and Flos Chrysanthemi preparation has coronary dilating, increase coronary artery blood flow, improve the effect of myocardial oxygen consumption, blood pressure lowering.Can also capillary permeability be suppressed and have antiinflammatory action; Chrysanthemum concrete gavage, has refrigeration function to the rabbit of artificial fever.

Semen Ziziphi Spinosae: sweet, acid, flat.Enter the heart, spleen, liver, gallbladder meridian.There is nourishing the liver, mind calming, calm the nerves, effect of arresting sweating.Cure mainly restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility." herbal classic ": " main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen "." not Lu ": " main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong "." book on Chinese herbal medicine converges and says ": " astringing QI is calmed the nerves, and flourish muscle supports marrow, stomach function regulating activating the spleen." " national Chinese herbal medicine compilation ": " cure mainly neurasthenia, insomnia, dreaminess, cardiopalmus, overflow antiperspirant "." Chinese medicine is complete works of ": " mind tranquilizing and the heart calming, arresting sweating promotes the production of body fluid.Cure mainly restlessness of asrhenia type and insomnia, palpitate with fear forgetful, sweating due to debility excessive thirst ".Zhu Zhenheng: " blood does not return spleen and the peaceful person that dosses, should with this (Semen Ziziphi Spinosae) large reinforcing the heart spleen, then blood return spleen and five hide peace and, doss from peaceful ".Compendium of Material Medica: its core is sweet and moisten, thus ripe treatment insomnia due to insufficiency of the gallbladder-qi, the card of excessive thirst sweating due to debility; Life is treated gallbladder-heat and is slept well.All foot faints the moon, few positive medicine also ".Semen Ziziphi Spinosae containing volume fatty oil and protein, and has two kinds of sterols, two kinds of triterpenoids (betulin, betulic acid), Semen Ziziphi Spinosae saponin, also containing volume vitamin C.Semen Ziziphi Spinosae decoct has calmness, syngignoscism, can resist the excitatory state that caffeine causes, show as synergism with barbiturate.Defensive type motion trained reflex number of times can be made to reduce, and interior suppression diffusion, trained reflex is cleared up and discharged.Decoct also has analgesia, convulsion, cooling effect.Semen Ziziphi Spinosae water soluble ingredient can cause blood pressure continuous decrease and heart-block also to have excited uterus to act on.

By monarch, minister, help, make the principles of formulating prescriptions analyze prescription compatibility of medicines:

Semen Ziziphi Spinosae sweet in the mouth, acid, flat.GUIXIN, Liver Channel.There is the liver benefiting that nourishes heart, calm the nerves, effect of arresting sweating.Especially be longer than the moon that nourishes heart, the liver benefiting blood, therefore have and enrich blood but the title of Semen Ziziphi Spinosae.Gu for we are to monarch drug.Ganoderma sweet in the mouth, put down, return the five internal organs through medicine." herbal classic ": main deafness, sharp joint, protects god, beneficial vital essence, hard muscles and bones, good color.The sweet flat matter profit of Fructus Jujubae, strengthening QI of middle-JIAO, and moisten hysteria with Semen Ziziphi Spinosae with better by effect, this medicine and Ganoderma are the ministerial drug of we altogether.Flos Chrysanthemi is sweet cool light clear, so-called reinforcing the heart person, the heart its head clear, the clear and god of head and quiet.This medicine is the adjuvant drug of we.Take a broad view of full side to nourish heart cloudy the liver benefiting blood, mend benifit stomach, settling five organs, mind tranquilizing and the heart calming, amount to the prosperous blood fortune of gas, the five internal organs peace and, doss from peace.Function: tranquilizing by nourishing the heart, blood yiqi, settling five organs, protects god, hard muscles and bones, good color.

Of the present invention have the health care oral liquid changing sleep quality effect, is a kind of calm catalyst formulations, can effective improving water flood quality.

Detailed description of the invention

Below in conjunction with embodiment, the present invention is further illustrated.

Embodiment 1 preparation has the health care oral liquid changing sleep quality effect

Composition of raw materials is: 400 kairine sesames, 200 grams of Flos Chrysanthemis, 600 grams of Fructus Jujubaes, 300 grams of Semen Ziziphi Spinosaes, 300 grams of Mel.

Step is as follows:

(1) get Ganoderma, Flos Chrysanthemi and Fructus Jujubae, Ganoderma is cut into the fritter of 0.3 ~ 0.4cm, Fructus Jujubae is cut into the fritter that thickness is 0.2 ~ 0.4cm; Three is added in the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour (in immersion process agitation as appropriate), filter, obtain filtrate and filtering residue, add the water that temperature is 95 ~ 98 DEG C in filtering residue again, soak 0.5 hour, filter, repeat this process 3 times, extract 4 times altogether, the quality of the water at every turn added is 12 kilograms; Merging filtrate, is concentrated into 600 grams, obtains paste;

(2) Semen Ziziphi Spinosae is got, pulverize, add the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour (in immersion process agitation as appropriate), filter, obtain filtrate and filtering residue, add the water of 95 ~ 98 DEG C in filtering residue again, soak 0.5 hour, filter, repeat this process 3 times, extract 4 times altogether, the quality of the water at every turn added is 3 kilograms; Merging filtrate, is concentrated into 150 grams, obtains Semen Ziziphi Spinosae paste;

95 alcoholic solution of 750ml are added, soak extraction 0.5 hour (in immersion process agitation as appropriate) in Semen Ziziphi Spinosae paste; Then, at-20 DEG C freezing 50 minutes, take out removing precipitation, supernatant concentration is to 250ml, then at-20 DEG C freezing 50 minutes, take out removing precipitation, supernatant concentration to 100 gram, obtained Semen Ziziphi Spinosae extract;

(3) step (1) gained paste is mixed with step (2) gained Semen Ziziphi Spinosae extract, obtain mixture, add Mel, mixing, obtain mixed liquor, add water 5000ml, dissolves, and filters, obtain, 100 DEG C of boiling water sterilizings 1 hour, canned 50ml/ bottle.Product Fructus Jujubae sweet in the mouth is sweet, and slightly have bitter sense, pure good to eat, liquid is clear and bright bright, places 18 months without any precipitation.

Zoopery checks preparation of the present invention to the sedation of mice: by this preparation of spontaneous activity in mice laboratory observation to the sedation of mice

Preparation of the present invention has sedative-hypnotic effect, and should suppress spontaneous activity in mice, comprise and walking about, forelimb is upwards praised, and scratches, and washes one's face, and licks foot, smells and stings.Be wherein common with the above two.

By 50ml preparation (prepared by above-mentioned steps 3) rotary evaporation to 5g, as calculated, 50ml said preparation is taken 1 time every day by the people of 1 60kg.Adopt 20g kunming mouse 1 gavage amount 1.7mg, 1.7mg is dissolved in 0.3ml water.Namely (containing this preparation of 1.7mg) is experiment 1 group to test gavage 0.3ml/ time through mice (20g body weight).The dosage 0.85mg/0.3ml that reduces by half is experiment 2 groups.Take normal saline as contrast, the time that observation is walked about and the number of times that forelimb is upwards praised.

Select kunming mouse (body weight 20g ± 1g) male and female half and half, random packet, often organize 10.The number of times that mice walking time and forelimb are upwards praised in 2 minutes is index.Before administration, mice is put into after case adapts to 5 minutes and record the Activity value of 2 minutes as normal value.Gavage measures the number of times that mice walking time and forelimb are upwards praised by the same method after 60 minutes.Within every 30 minutes later, measure once. represent result.Check with time t between group and check the significance of difference, result is as shown in table 1.

Table 1 preparation of the present invention is to the sedation of kunming mouse spontaneous activity (n=10)

Note: compare * * * p<0.01 with saline control group.

Experimental result: preparation of the present invention, to after kunming mouse gavage 1h, through observed and recorded, and contrasts with matched group, statistics walking time and forelimb upwards praise number of times, show that preparation of the present invention has obvious sedation.

Embodiment 2 preparation has the health care oral liquid changing sleep quality effect

Composition of raw materials is: 200 kairine sesames, 300 grams of Flos Chrysanthemis, 400 grams of Fructus Jujubaes, 200 grams of Semen Ziziphi Spinosaes, 200 grams of Mel.

Step is as follows:

(1) get Ganoderma, Flos Chrysanthemi and Fructus Jujubae, Ganoderma is cut into the fritter of 0.3 ~ 0.4cm, Fructus Jujubae is cut into the fritter that thickness is 0.2 ~ 0.4cm; Three is added in the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour (in immersion process agitation as appropriate), filter, obtain filtrate and filtering residue, add the water that temperature is 95 ~ 98 DEG C in filtering residue again, soak 0.5 hour, filter, repeat this process 3 times, extract 4 times altogether, the quality of the water at every turn added is 9 kilograms; Merging filtrate, is concentrated into 450 grams, obtains paste;

(2) Semen Ziziphi Spinosae is got, pulverize, add the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour (in immersion process agitation as appropriate), filter, obtain filtrate and filtering residue, add the water of 95 ~ 98 DEG C in filtering residue again, soak 0.5 hour, filter, repeat this process 3 times, extract 4 times altogether, the quality of the water at every turn added is 2 kilograms; Merging filtrate, is concentrated into 100 grams, obtains Semen Ziziphi Spinosae paste;

The dehydrated alcohol of 500ml is added, soak extraction 0.5 hour (in immersion process agitation as appropriate) in Semen Ziziphi Spinosae paste; Then, at-20 DEG C freezing 50 minutes, take out removing precipitation, supernatant concentration is to 170ml, then at-20 DEG C freezing 50 minutes, take out removing precipitation, supernatant concentration to 70 gram, obtained Semen Ziziphi Spinosae extract;

(3) step (1) gained paste is mixed with step (2) gained Semen Ziziphi Spinosae extract, obtain mixture, add Mel, mixing, obtain mixed liquor, add water 3600ml, dissolves, and filters, obtain, 100 DEG C of boiling water sterilizings 1 hour, canned 50ml/ bottle.Product Fructus Jujubae sweet in the mouth is sweet, and slightly have bitter sense, pure good to eat, liquid is clear and bright bright, places 18 months without any precipitation.

Embodiment 3 preparation has the health care oral liquid changing sleep quality effect

Composition of raw materials is: 600 kairine sesames, 100 grams of Flos Chrysanthemis, 800 grams of Fructus Jujubaes, 400 grams of Semen Ziziphi Spinosaes, 250 grams of Mel.

Step is as follows:

(1) get Ganoderma, Flos Chrysanthemi and Fructus Jujubae, Ganoderma is cut into the fritter of 0.3 ~ 0.4cm, Fructus Jujubae is cut into the fritter that thickness is 0.2 ~ 0.4cm; Three is added in the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour (in immersion process agitation as appropriate), filter, obtain filtrate and filtering residue, add the water that temperature is 95 ~ 98 DEG C in filtering residue again, soak 0.5 hour, filter, repeat this process 3 times, extract 4 times altogether, the quality of the water at every turn added is 15 kilograms; Merging filtrate, is concentrated into 750 grams, obtains paste;

(2) Semen Ziziphi Spinosae is got, pulverize, add the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour (in immersion process agitation as appropriate), filter, obtain filtrate and filtering residue, add the water of 95 ~ 98 DEG C in filtering residue again, soak 0.5 hour, filter, repeat this process 3 times, extract 4 times altogether, the quality of the water at every turn added is 4 kilograms; Merging filtrate, is concentrated into 200 grams, obtains Semen Ziziphi Spinosae paste;

The dehydrated alcohol of 1000ml is added, soak extraction 0.5 hour (in immersion process agitation as appropriate) in Semen Ziziphi Spinosae paste; Then, at-20 DEG C freezing 50 minutes, take out removing precipitation, supernatant concentration is to 330ml, then at-20 DEG C freezing 50 minutes, take out removing precipitation, supernatant concentration to 130 gram, obtained Semen Ziziphi Spinosae extract;

(3) step (1) gained paste is mixed with step (2) gained Semen Ziziphi Spinosae extract, obtain mixture, add Mel, mixing, obtain mixed liquor, add water 5650ml, dissolves, and filters, obtain, 100 DEG C of boiling water sterilizings 1 hour, canned 50ml/ bottle.Product Fructus Jujubae sweet in the mouth is sweet, and slightly have bitter sense, pure good to eat, liquid is clear and bright bright, places 18 months without any precipitation.

The effect of preparation of the present invention after edible for patients (model case)

Case 1: Liu xx, female, 60 years old, retired worker, first visit date: on March 26th, 2012.Patient often has a sleepless night, dizzy, forgetful, and recently increase the weight of because bothering excessively insomnia, a few days can not sleep peacefully even continuously.Sleep, easily wake up, companion's cardiopalmus, vexed, weakness of the waist and knees, being reticent, light red tongue, yellow fur, thready and rapid pulse.Start to take preparation of the present invention (prepared by embodiment 1), once a day, each 50ml, after taking one week continuously, symptom obviously alleviates, and advise following the service 20 doses, all diseases disappear substantially, and facial QI and blood is ruddy.

Case 2 a: xx, female, 50 years old, teacher, first visit date: on June 16th, 2012.Patient is on the occasion of climacteric, and anxiety of in addition overworking, daily life is variable, and cause companioned with headache of having a sleepless night, emotion is easily irritable, recent exacerbation of symptoms, light red tongue, yellow fur, stringy pulse.Start to take preparation of the present invention (prepared by embodiment 1), once a day, each 50ml, after taking one week, symptom obviously alleviates, and advise following the service 20 doses, all diseases disappear substantially, are emotionally stable, and QI and blood is ruddy.

Claims (10)

1. there is the health care oral liquid changing sleep quality effect, it is characterized in that: be with 2 ~ 6 portions of Ganodermas, 1 ~ 3 part of Flos Chrysanthemi, 4 ~ 8 portions of Fructus Jujubaes, 2 ~ 4 parts of Semen Ziziphi Spinosaes, 2 ~ 3 parts of Mel for raw material, prepare through following methods:

(1) Ganoderma, Flos Chrysanthemi and Fructus Jujubae is got, adding temperature is in the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour, filters, obtains filtrate and filtering residue, the water that temperature is 95 ~ 98 DEG C is added again in filtering residue, soak 0.5 hour, filter, repeat this process 1 ~ 3 time, extract 2 ~ 4 times altogether, the quality of the water at every turn added is 8 ~ 12 times of three's gross weight; Merging filtrate, concentrated, obtain paste;

(2) Semen Ziziphi Spinosae is got, pulverize or smash, adding the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour, filter, obtain filtrate and filtering residue, add the water of 95 ~ 98 DEG C in filtering residue again, soak 0.5 hour, filter, repeat this process 1 ~ 3 time, extract 2 ~ 4 times altogether, the quality of the water at every turn added is 8 ~ 12 times of Semen Ziziphi Spinosae weight; Merging filtrate, concentrated, obtain Semen Ziziphi Spinosae paste;

95 ~ 100% alcoholic solution of 5 times are added, soak extraction 0.5 hour in Semen Ziziphi Spinosae paste; Then, at-10 ~-26 DEG C freezing 40 ~ 60 minutes, take out removing precipitation, supernatant concentration, then at-10 ~-26 DEG C freezing 40 ~ 60 minutes, take out removing precipitation, supernatant concentration, obtains Semen Ziziphi Spinosae extract;

(3) mixed with step (2) gained Semen Ziziphi Spinosae extract by step (1) gained paste, obtain mixture, add Mel, mixing, obtains mixed liquor, adds water dissolution, filters, to obtain final product.

2. according to claim 1 have the health care oral liquid changing sleep quality effect, it is characterized in that: in described step (1), be concentrated into 1/2 of three's gross weight, obtain paste.

3. according to claim 1 have the health care oral liquid changing sleep quality effect, it is characterized in that: in described step (2), be concentrated into 1/2 of Semen Ziziphi Spinosae weight, obtain Semen Ziziphi Spinosae paste; Supernatant concentration, to 1/3 of Semen Ziziphi Spinosae weight, obtains Semen Ziziphi Spinosae extract.

4. according to claim 1 have the health care oral liquid changing sleep quality effect, it is characterized in that: in described step (3), add the water of mixed liquor 5 times of weight.

5. the health care oral liquid with change sleep quality effect according to any one of Claims 1 to 4, it is characterized in that: be with 2 ~ 6 portions of Ganodermas, 1 ~ 3 part of Flos Chrysanthemi, 4 ~ 8 portions of Fructus Jujubaes, 2 ~ 4 parts of Semen Ziziphi Spinosaes, 2 ~ 3 parts of Mel for raw material, prepare through following methods:

(1) Ganoderma, Flos Chrysanthemi and Fructus Jujubae is got, adding temperature is in the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour, filters, obtains filtrate and filtering residue, the water that temperature is 95 ~ 98 DEG C is added again in filtering residue, soak 0.5 hour, filter, repeat this process 3 times, extract 4 times altogether, the quality of the water at every turn added is 10 times of three's gross weight; Merging filtrate, is concentrated into 1/2 of three's gross weight, obtains paste;

(2) Semen Ziziphi Spinosae is got, pulverize or smash, adding the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour, filter, obtain filtrate and filtering residue, add the water of 95 ~ 98 DEG C in filtering residue again, soak 0.5 hour, filter, repeat this process 3 times, extract 4 times altogether, the quality of the water at every turn added is 10 times of Semen Ziziphi Spinosae weight; Merging filtrate, is concentrated into 1/2 of Semen Ziziphi Spinosae weight, obtains Semen Ziziphi Spinosae paste;

95 ~ 100% alcoholic solution of 5 times are added, soak extraction 0.5 hour in Semen Ziziphi Spinosae paste; Then, at-10 ~-26 DEG C freezing 40 ~ 60 minutes, take out removing precipitation, supernatant concentration is to 1/3 of original volume, then at-10 ~-26 DEG C freezing 40 ~ 60 minutes, take out removing precipitation, supernatant concentration, to 1/3 of Semen Ziziphi Spinosae weight, obtained Semen Ziziphi Spinosae extract;

(3) mixed with step (2) gained Semen Ziziphi Spinosae extract by step (1) gained paste, obtain mixture, add Mel, mixing, obtains mixed liquor, adds the water dissolution of mixed liquor 5 times of weight, filters, to obtain final product.

6. the preparation method with the health care oral liquid changing sleep quality effect according to claim 1, is characterized in that: step is as follows:

(1) Ganoderma, Flos Chrysanthemi and Fructus Jujubae is got, adding temperature is in the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour, filters, obtains filtrate and filtering residue, the water that temperature is 95 ~ 98 DEG C is added again in filtering residue, soak 0.5 hour, filter, repeat this process 1 ~ 3 time, extract 2 ~ 4 times altogether, the quality of the water at every turn added is 8 ~ 12 times of three's gross weight; Merging filtrate, concentrated, obtain paste;

(2) Semen Ziziphi Spinosae is got, pulverize or smash, adding the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour, filter, obtain filtrate and filtering residue, add the water of 95 ~ 98 DEG C in filtering residue again, soak 0.5 hour, filter, repeat this process 1 ~ 3 time, extract 2 ~ 4 times altogether, the quality of the water at every turn added is 8 ~ 12 times of Semen Ziziphi Spinosae weight; Merging filtrate, concentrated, obtain Semen Ziziphi Spinosae paste;

95 ~ 100% alcoholic solution of 5 times are added, soak extraction 0.5 hour in Semen Ziziphi Spinosae paste; Then, at-10 ~-26 DEG C freezing 40 ~ 60 minutes, take out removing precipitation, supernatant concentration, then at-10 ~-26 DEG C freezing 40 ~ 60 minutes, take out removing precipitation, supernatant concentration, obtains Semen Ziziphi Spinosae extract;

(3) mixed with step (2) gained Semen Ziziphi Spinosae extract by step (1) gained paste, obtain mixture, add Mel, mixing, obtains mixed liquor, adds water dissolution, filters, to obtain final product.

7. preparation method according to claim 6, is characterized in that: in described step (1), be concentrated into 1/2 of three's gross weight, obtain paste.

8. preparation method according to claim 6, is characterized in that: in described step (2), be concentrated into 1/2 of Semen Ziziphi Spinosae weight, obtain Semen Ziziphi Spinosae paste; Supernatant concentration, to 1/3 of Semen Ziziphi Spinosae weight, obtains Semen Ziziphi Spinosae extract.

9. preparation method according to claim 6, is characterized in that: in described step (3), add the water of mixed liquor 5 times of weight.

10. the preparation method according to any one of claim 6 ~ 9, is characterized in that: step is as follows:

(1) Ganoderma, Flos Chrysanthemi and Fructus Jujubae is got, adding temperature is in the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour, filters, obtains filtrate and filtering residue, the water that temperature is 95 ~ 98 DEG C is added again in filtering residue, soak 0.5 hour, filter, repeat this process 3 times, extract 4 times altogether, the quality of the water at every turn added is 10 times of three's gross weight; Merging filtrate, is concentrated into 1/2 of three's gross weight, obtains paste;

(2) Semen Ziziphi Spinosae is got, pulverize or smash, adding the water of 95 ~ 98 DEG C, heat-insulation soaking 0.5 hour, filter, obtain filtrate and filtering residue, add the water of 95 ~ 98 DEG C in filtering residue again, soak 0.5 hour, filter, repeat this process 3 times, extract 4 times altogether, the quality of the water at every turn added is 10 times of Semen Ziziphi Spinosae weight; Merging filtrate, is concentrated into 1/2 of Semen Ziziphi Spinosae weight, obtains Semen Ziziphi Spinosae paste;

95 ~ 100% alcoholic solution of 5 times are added, soak extraction 0.5 hour in Semen Ziziphi Spinosae paste; Then, at-10 ~-26 DEG C freezing 40 ~ 60 minutes, take out removing precipitation, supernatant concentration is to 1/3 of original volume, then at-10 ~-26 DEG C freezing 40 ~ 60 minutes, take out removing precipitation, supernatant concentration, to 1/3 of Semen Ziziphi Spinosae weight, obtained Semen Ziziphi Spinosae extract;

(3) mixed with step (2) gained Semen Ziziphi Spinosae extract by step (1) gained paste, obtain mixture, add Mel, mixing, obtains mixed liquor, adds the water dissolution of mixed liquor 5 times of weight, filters, to obtain final product.