CN108619418A - A kind of instant particles as Chinese medicine and preparation method for treating climacteric sleep disturbance - Google Patents

A kind of instant particles as Chinese medicine and preparation method for treating climacteric sleep disturbance Download PDF

Info

Publication number
CN108619418A
CN108619418A CN201810938337.5A CN201810938337A CN108619418A CN 108619418 A CN108619418 A CN 108619418A CN 201810938337 A CN201810938337 A CN 201810938337A CN 108619418 A CN108619418 A CN 108619418A
Authority
CN
China
Prior art keywords
parts
fruit
seed
radix
liver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201810938337.5A
Other languages
Chinese (zh)
Inventor
张美丽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201810938337.5A priority Critical patent/CN108619418A/en
Publication of CN108619418A publication Critical patent/CN108619418A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254—Acanthopanax or Eleutherococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486—Millettia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638—Ligustrum, e.g. Chinese privet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a kind of instant particles as Chinese medicine and preparation method for treating climacteric sleep disturbance, belong to the field of Chinese medicines.The raw material group of effective ingredient of the present invention becomes：Whorledleaf solomonseal rhizome, mulberry fruit, bamboo juice, arillus longan, evergreen mucuna root and leaf, Polygonum multiflower knotweed, leopard mushroom, lotus-seed kernel, Huai wheat, Semen sesami nigrum, Radix Glycyrrhizae, the fruit of glossy privet, the seed of Oriental arborvitae, Radix Rhodiolae Dumulosae, twoleaf swertia herb, dogwood fruit, American Ginseng, Radix Polygalae, Eleutherococcus Brachypus, Herba Lycopi, Schisandra chinensis, rush, luffa, mother-of-pearl.The present invention selects medicinal material to meet a monarch and his subjects left side and is allowed to manage, it suits the remedy to the case for the cause of disease, tonify the liver and kidney, nourishing yin and nourishing blood, calming the liver, clearing heart fire, mental-tranquilization, blood-enrich, clearing and activating the channels and collaterals, inducing astrigency arrest sweating the effect of, good absorption effect, it is significant in efficacy, it is higher to climacteric sleep disturbance cure rate according to clinical verification.

Description

A kind of instant particles as Chinese medicine and preparation method for treating climacteric sleep disturbance
Technical field
The present invention relates to the field of Chinese medicines more particularly to a kind of instant particles as Chinese medicine for treating climacteric sleep disturbance and preparation sides Method.
Background technology
Sleep is the important component of human life activity, and sleep quality is significantly correlated with quality of life.Sleep disturbance It means that sleep matter and (or) amount change during Sleep-Wake, and the various functions obstacle that occurs together, a system can be directly resulted in The health problems such as row mental handicape, Somatic discomfort or other diseases, seriously affect life quality.Sleep disturbance in crowd very Generally, women is especially apparent, and menopause is climacteric on female pathology, in menopause transition, because ovarian function subtracts It moves back, about 2/3rds women may occur in which a series of symptoms caused by sex hormone level changes.Epidemiologic data prompts, The incidence of climacteric and postmenopausal women sleep disturbance increases, and insomnia is very common in climacteric women, mainly Show as difficulty falling asleep, sleep is not deep, easily wake up with a start, dreaminess, early awakening, wake up after be not easy to sleep again, wake up after sense discomfort, and be often accompanied by night Urine number increases, and it is tired sleepy etc. to warm perspiration, daytime.
Modern medicine thinks that climacteric insomnia is related with estrogen level reduction, angiokinesis variation, emotional handicap.West Doctor mostly uses hormone replacement therapy or application hypnotic sedative agent etc. for the treatment of this disease, although having certain effect in short term, It takes such drug, curative effect is unsatisfactory for a long time, and will produce certain side effect and drug dependence, it is not easy to be discontinued, stop Medicine easily recurs.
In traditional Chinese medicine, climacteric sleep disturbance surely belongs in " menopausal disorders " scope of " being insomnia ".The present invention recognizes For this disease origin cause of formation multiterminal, lesion is related to how dirty, mainly related with kidney, liver, the heart, the perimenopausal women generally existing deficiency of liver-yin and kidney-yin, Kidney water is short, loses in upper Ji internal heat, self-restraint edema with the liver involved, and internal heat is partially prosperous, cannot meet at kidney down, the fire of deficiency type disturbs god, and liver loses soft foster, liver-yang Rising, disturbing the mind upwards can lead to the clinical symptoms such as insomnia, thus be disturbed in the deficiency of liver-yin and kidney-yin, breakdown of the normal physiological coordination between the heart and the kidney, internal heat, liver-yang hyperactivity It is the principle pathological mechanism of climacteric sleep disturbance.Chinese medicine of the present invention is configured through long-term clinical practice summary, is had and is mended The effect of liver and kidney benefiting, nourishing yin and nourishing blood, calming the liver, clearing heart fire, mental-tranquilization, blood-enrich, clearing and activating the channels and collaterals, inducing astrigency arrest sweating, Good absorption effect, it is significant in efficacy, it is higher to climacteric sleep disturbance cure rate according to clinical verification.
Invention content
The present invention provides a kind of instant particles as Chinese medicine and preparation method for treating climacteric sleep disturbance, have help liver It the effect of kidney, nourishing yin and nourishing blood, calming the liver, clearing heart fire, mental-tranquilization, blood-enrich, clearing and activating the channels and collaterals, inducing astrigency arrest sweating, cures the disease Source treating both manifestation and root cause of disease is sought, fine curative effect is all had to climacteric sleep disturbance caused by a variety of causes.
To achieve the above object, technical scheme of the present invention is implemented as follows：
The raw material composition and parts by weight of the effective ingredient is made in a kind of instant particles as Chinese medicine for treating climacteric sleep disturbance Number is：
20~40 parts of whorledleaf solomonseal rhizome, 20~40 parts of mulberry fruit, 20~40 parts of bamboo juice, 20~40 parts of arillus longan,
15~30 parts of evergreen mucuna root and leaf, 15~30 parts of Polygonum multiflower knotweed, 15~30 parts of leopard mushroom, 10~25 parts of lotus-seed kernel,
10~25 parts of Huai wheat, 10~25 parts of Semen sesami nigrum, 10~20 parts of Radix Glycyrrhizae, 10~20 parts of the fruit of glossy privet,
9~15 parts of the seed of Oriental arborvitae, 9~15 parts of Radix Rhodiolae Dumulosae, 9~15 parts of twoleaf swertia herb, 6~12 parts of dogwood fruit,
6~12 parts of American Ginseng, 3~9 parts of Radix Polygalae, 3~9 parts of Eleutherococcus Brachypus, 3~9 parts of Herba Lycopi,
3~9 parts of Schisandra chinensis, 3~9 parts of rush, 1~6 part of luffa, 1~4 part of mother-of-pearl.
The raw material that the effective ingredient is made forms and parts by weight are：
25~35 parts of whorledleaf solomonseal rhizome, 25~35 parts of mulberry fruit, 25~35 parts of bamboo juice, 25~35 parts of arillus longan,
20~25 parts of evergreen mucuna root and leaf, 20~25 parts of Polygonum multiflower knotweed, 20~25 parts of leopard mushroom, 15~20 parts of lotus-seed kernel,
15~20 parts of Huai wheat, 15~20 parts of Semen sesami nigrum, 14~18 parts of Radix Glycyrrhizae, 14~18 parts of the fruit of glossy privet,
10~13 parts of the seed of Oriental arborvitae, 10~13 parts of Radix Rhodiolae Dumulosae, 10~13 parts of twoleaf swertia herb, 8~10 parts of dogwood fruit,
8~10 parts of American Ginseng, 4~8 parts of Radix Polygalae, 4~8 parts of Eleutherococcus Brachypus, 4~8 parts of Herba Lycopi,
4~6 parts of Schisandra chinensis, 4~6 parts of rush, 1~4 part of luffa, 1~3 part of mother-of-pearl.
The raw material that the effective ingredient is made forms and parts by weight are：
30 parts of whorledleaf solomonseal rhizome, 30 parts of mulberry fruit, 30 parts of bamboo juice, 30 parts of arillus longan,
24 parts of evergreen mucuna root and leaf, 24 parts of Polygonum multiflower knotweed, 24 parts of leopard mushroom, 18 parts of lotus-seed kernel,
18 parts of Huai wheat, 18 parts of Semen sesami nigrum, 16 parts of Radix Glycyrrhizae, 16 parts of the fruit of glossy privet,
12 parts of the seed of Oriental arborvitae, 12 parts of Radix Rhodiolae Dumulosae, 12 parts of twoleaf swertia herb, 9 parts of dogwood fruit,
9 parts of American Ginseng, 6 parts of Radix Polygalae, 6 parts of Eleutherococcus Brachypus, 6 parts of Herba Lycopi,
5 parts of Schisandra chinensis, 5 parts of rush, 3 parts of luffa, 2 parts of mother-of-pearl.
A kind of preparation method of instant particles as Chinese medicine that treating climacteric sleep disturbance, comprises the following steps that：
（1）Whorledleaf solomonseal rhizome, mulberry fruit, arillus longan, evergreen mucuna root and leaf, Schisandra chinensis are put into container, the second of the concentration 80% of 4 times of amounts is added Alcoholic solution impregnates 1-2 hours, heating and refluxing extraction 3-4 hours, and it is spare to obtain filtrate for filtering；
（2）By bamboo juice, Polygonum multiflower knotweed, leopard mushroom, lotus-seed kernel, Huai wheat, Semen sesami nigrum, the fruit of glossy privet, the seed of Oriental arborvitae, Radix Rhodiolae Dumulosae, twoleaf swertia herb, mountain Cornus, American Ginseng, Eleutherococcus Brachypus, Herba Lycopi, rush, mother-of-pearl are put into container, and the 8-10 times of distilled water immersion 4-5 measured is added Hour, heating is boiled 3-4 hours, and immersion liquid is extracted；The 6-8 times of distilled water measured is added again, heating is boiled 2-3 hours, extraction leaching Liquid；The 4-6 times of distilled water measured finally is added, heating is boiled 1-2 hours, and immersion liquid is extracted；Merge immersion liquid three times, filtering must filter Liquid is spare；
（3）Net licorice tablet is taken, cooked honey and a little boiling water is added, it is slightly bored after mixing thoroughly, it sets in frying container, is fried with slow fire depth Yellow is taken out when tack-free, cools, and crushing is ground, and crosses 140 mesh dusting covers, obtains fine powder, spare；
（4）Certain amount of boiling water and even is added with furnacing honey, admixes honey-fried RADIX POLYGALAE, slightly bored, micro- to fry to tack-free as degree, taking-up cools, powder It is broken to grind, 140 mesh dusting covers are crossed, fine powder is obtained, it is spare；
（5）The luffa for being cut into segment is taken, is stirred to yellow degree of being with wheat bran, is taken out, weed out wheat bran, crushing is ground, and 140 mesh are crossed Dusting cover obtains fine powder, spare；
（6）By step（1）, step（2）The filtrate of gained, with step（3）, step（4）, step（5）The fine powder of middle gained adds auxiliary Particle is made in material sucrose and dextrin after mixing, dries, after whole grain, is packaged into the instant particles as Chinese medicine of every bag of 6g.
The pharmacological property of Chinese medicine used in the present invention is as follows：
Whorledleaf solomonseal rhizome：It is sweet in flavor；Slight bitter；It is cool in nature.It is nourishing liver and kidney, nourishing Yin and promoting production of body fluid.For neurasthenia, high blood pressure, headache, throat Bitterly, it quenches one's thirst, mouth parched and tongue scorched.《The sweet peaceful green Chinese herbal medicine choosing in Shan》：" tonifying spleen moistening lung, promotes the production of body fluid.Pulmonary tuberculosis is controlled, eak after being ill is thirsty, god Through weak, the liver-yang headache, loss of appetite, lassitude in loin and legs, diabetes."
Mulberry fruit：It is sweet in flavor；Acid；It is cold in nature.Return liver；Kidney channel.Nourishing yin and nourishing blood；It promotes the production of body fluid；Ease constipation.Cure mainly what kidney deficiency and liver and deficiency of blood essence were lost It has a dizzy spell；Soreness of waist tinnitus；Poliosis；Insomnia and dreamful sleep；Injury thirst；It quenches one's thirst；Dry constipation of intestines.
Bamboo juice：It is sweet in flavor；It is bitter；It is cold in nature.The thoughts of returning home；Liver；Lung channel.Heat-clearing and fire-reducing；Sliding phlegm profit key.Cure mainly stroke and phlegm confusing heart；Lung heat phlegm Stop up；Infantile convulsion；Epilepsy；Pyreticosis abundant expectoration；High fever polydipsia；Restlessness during pregnancy；Lockjaw.《Book on Chinese herbal medicine is new again》：" clearing away the heart-fire, reducing liver heat, resolving sputum stop Yearningly, toothache, bright eyes are controlled in antipyretic relieving restlessness."
Arillus longan：It is sweet in flavor；It is warm-natured.Enter the heart；Kidney；Liver；The spleen channel.Bushing spleen；Replenishing qi and blood；Tranquilizing mind.Cure mainly the insufficiency of heart and spleen, qi and blood not Palpitation with fear caused by foot；Palpitation；Insomnia；It is forgetful；Blood deficiency chlorosis；Irregular menstruation；Uterine bleeding.《It obtains with book on Chinese herbal medicine》It carries：" Energy benefit taste preserves the heart Blood, moisturizing viscera control palpitation." modern medical studies have confirmed that arillus longan has obviously cardiac muscle by the stimulation of low temperature, high temperature and anoxic Protective effect, have inhibiting effect to Microsporon audouini, in addition there are calm and digestion promoting functions.
Evergreen mucuna root and leaf：It is sweet in flavor, it is warm-natured.It is promoting blood circulation and removing blood stasis, dispelling wind and eliminating dampness, clearing and activating the channels and collaterals.For traumatic injury, rheumatalgia pain, numbness are led to Through Amenorrhea.《Classify herbal》：" control cold spleen wind, rheumatic numbness, arthralgia and myalgia, detumescence."
Polygonum multiflower knotweed：It is sweet in flavor；Slight bitter；It is mild-natured.Enter the heart；Liver Channel.Mental-tranquilization；Wind-dispelling；Dredging collateral.Cure mainly insomnia；Dreaminess；Deficiency of blood body Bitterly；Numbness；Arthralgia pain due to rheumatism；Rubella itch.《Medicine materical crude slice is newly joined》It carries：" nourishing liver and kidney, only abnormal sweating, tranquilizing the mind hypnosis, bowl spares gas are gone Internal lesion caused by overexertion is controlled in channels and collaterals, promoting blood circulation." modern medical studies have confirmed that Polygonum multiflower knotweed contains rheum emodin, Physcion, with yellow Jackets In synergistic effect, there is significant calm, syngignoscism, especially extend slow wave sleep phase.
Leopard mushroom：It is sweet in flavor；It is mild-natured.The thoughts of returning home；The spleen channel.It fills blood；Heart-spleen boosting.Cure mainly insufficiency of vital energy and blood；The insufficiency of heart and spleen；Tired nothing Power；Insomnia palpitaition.
Lotus-seed kernel：It is sweet in flavor；It is puckery；It is mild-natured.Enter the heart；Spleen；Kidney；Stomach；Liver；Bladder warp.Tonifying spleen and stopping diarrhea；Supplementing the kidney to control the nocturnal；Mental-tranquilization. Cure mainly spleen deficiency chronic diarrhea；Protracted dysentery；Emission due to the kidney deficiency；Lingering diarrhea；Urinary incontinence；Under married woman's uterine bleeding band；Have no peace of mind；Palpitation with fear；Egersis.《Guiding principle Mesh》It carries：" kidney of laying one's heart bear, thick stomach, solid essence, strengthening the bones and muscles, qi-restoratives damage, sharp knowledge, eliminating cold-damp, only the splenic diarrhea protracted dysentery, reddish and whitish turbid urine, female People reposes with all blood diseases of lower metrorrhagia, main bowl spares, benefiting energy.”
Huai wheat：It is sweet in flavor；It is mild-natured.Enter the heart channel of Hang-Shaoyin.Mental-tranquilization.It is not peaceful to cure mainly mind；The diseases such as insomnia.《Synopsis Golden Chamber》It carries：It " controls dirty It is hot-tempered, abnormal sweating can be held back, and have QI invigorating, nourishing heart, except hot merit is used, can be used for fever due to yin deficiency, the cards such as hectic fever due to yin labor heat." Huai wheat is good at supporting The heart is with will of allaying excitement, and for the disease that abnormal mind and uneasy sleeping at night etc. are had no peace of mind, often coordinates Radix Glycyrrhizae, jujube with using, there is nourishing heart Sedative action.
Semen sesami nigrum：It is sweet in flavor；It is mild-natured.Return liver；Spleen；Kidney channel.It tonifies the liver and kidney；Blood-nourishing strengthening the essence；It relaxes bowel.For dizzy eye Flower, Hiccough and deaf, poliosis, post disease alopecia, dry constipation of intestines.Modern medicine study proves：Semen sesami nigrum have hypoglycemic effect, Promote adrenal gland effect, anti-inflammatory effect and has certain effect to angiocarpy.
Radix Glycyrrhizae：It is sweet in flavor；It is mild-natured.The thoughts of returning home；Lung；Spleen；Stomach.It invigorates the spleen and benefits qi；It is clearing heat and detoxicating；Expelling phlegm and arresting coughing；Relieving spasm to stop pain；It adjusts With all medicines.It cures mainly weakness of the spleen and the stomach；Lassitude hypodynamia；Palpitation；Coughing with a lot of sputum；Gastral cavity abdomen four limbs contraction；Carbuncle sore tumefacting virus；Alleviate Drug toxicity.《Compendium of Materia Medica》It carries：" Radix Glycyrrhizae is monarch in all medicines.72 kinds of mammary calculus poison are controlled, draft is malicious by every means for solution 1,002, adjusts With it is active from medicine." modern medical studies have confirmed that Radix Glycyrrhizae has a stronger detoxication, also antiulcer, anti-inflammatory, antispastic antibechic, Lowering blood pressure and blood fat, antitumaous effect are widely used in treatment sphagitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis Etc. diseases, additionally have anti-gastric-ulcer, gastritis effect.
The fruit of glossy privet：Bitter；It is cool in nature.Return liver；Kidney channel.Tonifying liver kidney yin, crow must improving eyesight.Cure mainly the deficiency of liver-yin and kidney-yin；Soreness of waist tinnitus；Palpus Hair is early white；Unseeing；Fever due to yin deficiency；Stomach trouble and gout and hyperuricemia.《Book on Chinese herbal medicine is new again》：Replenishing vital essence to strengthen the kidney, tonifying Qi are relaxed liver. Control waist-leg pain, promoting menstruation and blood.Modern medicine study proves, the fruit of glossy privet has a reducing blood lipid, antiatherosclerosis, cardiac stimulant, diuresis, Cough-relieving, laxative, antibacterial and hepatoprotective effect can improve peripheral leukocytes, enhancing reticuloendothelial system phagocytic activity, there is enhancing cell Immune and humoral immunity effect, has raising effect to the Neuroleptic Leukocytopenia caused by chemotherapy or radiotherapy, animal can be inhibited certain The growth of transplanted tumor.
The seed of Oriental arborvitae：It is sweet in flavor；It is mild-natured.The thoughts of returning home；Kidney；Large intestine channel.Mental-tranquilization；Arrest sweating；It relaxes bowel.Cure mainly palpitation with fear palpitation； Insomnia forgetfulness；Night sweat；Dry constipation of intestines.《Drugization justice》It carries：" the saturating heart of fragrance, body profit grow blood, and it is timid to cure mainly mind void, palpitation of palpitating with fear, Color is wan and sallow, and skin is dry to itch, all the work(of nourishing heart blood." modern medical studies have confirmed that the seed of Oriental arborvitae contains a large amount of unsaturated fats Sour, a small amount of volatile oil and multivitamin, saponin(e, phytosterol and protein improve immunity of organisms, are chiefly used in treatment variation Property angina pectoris and rheumatic coronary heart disease.
Radix Rhodiolae Dumulosae：Sweet-puckery flavor slight bitter, it is warm-natured.Kidney tonifying, mental-tranquilization, regulating menstruation and activating blood, improving eyesight.Consumptive disease is controlled, hectic fever due to yin labor heat is done Blood labor, irregular menstruation are had a dizzy spell.
Twoleaf swertia herb：It is sweet in flavor；Slight bitter；It is mild-natured.The thoughts of returning home；Liver Channel.Pinggan Yang；Mental-tranquilization；Nourishing blood for regulating menstruation.Cure mainly dizziness；God Through weak；High blood pressure；Anaemia；Irregular menstruation.
Dogwood fruit：It is sour；Slightly warm in nature, Return liver；Kidney channel.It tonifies the liver and kidney；Astringing and avoiding visceroptosis cures mainly：It has a dizzy spell；Deaf ear Ring；Soreness and weakness of waist and knees；Xian essence involuntary emission；Frequent urination；Incessant sweating due to debility；Woman uterine bleeding.《Elementary Medicine》：This astringent of Fructus Corni, what With can lead to hair it is evil to cover all diseases be all the lower part cold of insufficiency type, with benefit nourishing liver and kidney, with Yi Qiyuan, then the five internal organs Amway, the person of closing is led to and profit person stops, The meaning of the light dredging of Fei Ruota medicines.Modern medicine study shows：Dogwood fruit has antibacterial, adjusts immune, hypoglycemic, drop blood The functions such as fat, anti-oxidant, anticancer, cardiac stimulant.
American Ginseng：It is sweet in flavor；Slight bitter；It is cold in nature.Return lung；Stomach；The heart；Kidney channel.Boosting qi and nourishing yin；It relieves inflammation or internal heat and promotes the production of body fluid.It cures mainly：The deficiency of vital energy is cloudy specially Hyperactivity of fire, phlegm blood of coughing, abnormal heat are tired of that tired, Heat Diabetes, the dry cigarette of mouth are dry.《Book on Chinese herbal medicine asks former》：Clearing lung-heat kidney, cool heart spleen are relieved summer heat with fall fire, It relieves the effect of alcohol.Modern study proves that：Saponin in American Ginseng can effectively enhance nervous centralis, reach it is with all worries set aside with fixed attention, dispelling fatigue, increasing The effects that strong memory；American Ginseng can with anti-arrhythmia, resist myocardial ischemia, it is anti-cardiac muscle oxidation, strengthen cardiac contractility ability；West Immunity of organisms can be improved in American ginseng, reduces blood coagulability, inhibits platelet aggregation, antiatherosclerosis and promote red blood cell Growth increases hemochrome；American Ginseng can reduce blood glucose, adjust insulin secretion, promote glycometabolism and fat metabolism, to controlling Treating diabetes has certain booster action.
Radix Polygalae：Bitter；It is pungent；It is warm-natured.The thoughts of returning home；Kidney；Lung channel.Tranquilize the mind and promote the intelligence；Eliminating the phlegm；Detumescence.Caused by curing mainly breakdown of the normal physiological coordination between the heart and the kidney Insomnia and dreamful sleep, forgetful palpitation with fear is wandering, and expectoration is not well, sore swollen toxin, mastosis.《Sheng Nong's herbal classic》It carries：" main cough is inverse In wound, tonifying for the deficiency, remove pathogenic factor, sharp nine orifices, intelligence development is intelligent, and normal hearing and eyesight is not forgotten, strong will times power." modern medical studies have confirmed that remote Will has calm, anticonvulsant action, has excited stimulation to smooth muscle and cardiac muscle, in addition there are inhibit alcohol absorption, it is anti-oxidant, The effects that anti-aging.
Eleutherococcus Brachypus：It replenishes qi to invigorate the spleen；Mental-tranquilization；Xie Yu and blood.It is physically weak weak to cure mainly Woman climacteric；Hectic fever, insomnia； Depression is not joyous；It is forgetful；Palpitaition；It is dizzy；Headache；Arthralgia.
Herba Lycopi：Acrid flavour；Slight bitter；Property is micro- wet.Return liver；The spleen channel.Invigorate blood circulation；Stagnation resolvation row water.Cure mainly irregular menstruation；Dysmenorrhoea； Amenorrhea；Postpartum abdominal pain；Wei lump in the abdomen；Body and face edema；Carbuncle；Traumatic injury.《Often use Chinese herbal medicine in Sichuan》It carries：" red Herba Lycopi, dispersing blood stasis row water, Easypro liver dissipates strongly fragrant." modern medical studies have confirmed that red Herba Lycopi contains volatile oil, tannin, phenols and a variety of amino acid, it can anti-tampon shape At playing the role of slightly inhibiting blood coagulation system and enhancing fibrinolytic.
Schisandra chinensis：Acrid flavour；It is bitter；It is warm-natured.Restrain astringent method；Nourishing generate fluid；Kidney calming.For long-last cough and virtual asthma, emission, Enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, injury thirst, feeble pulse of losing heart, Heat Diabetes, palpitation and insomnia.《This warp》It carries：It is " main QI invigorating, cough with dyspnea, the thin degree of internal lesion caused by overexertion, tonifying for the deficiency, Qiang Yin." modern medical studies have confirmed that Schisandra chinensis contain abundant organic acid, Vitamin, flavonoids, phytosterol and the lignan for having potent reactivation, it be also have both essence, gas, refreshing three big helps are lacked One of number medicinal material, the strong liver of energy QI invigorating, the efficiency for promoting cell exclusion waste supply more oxygen, nutrition and with energy, raising Memory and property endurance.
Rush：It is sweet in flavor；It is light；Cold nature.The thoughts of returning home；Lung；Small intestine；Bladder warp.Promoting diuresis for stranguria；Clearing heart fire.Cure mainly gonorrhoea； Oedema；Difficult urination；Jaundice with damp-heat pathogen；Dysphoria and insomnia；Nocturnal fretfulness in infants；Larynx numbness；Aphtha；Wound.《The common Chinese herbal medicine handbook in the north》： Heat clearing and tranquillizing, promoting diuresis for stranguria.
Luffa：Bitter；It is cool in nature.Return lung；Liver；Stomach.Clearing and activating the channels and collaterals, clearing heat and detoxicating, inducing diuresis to remove edema, hemostasis.Cure mainly chest Distending pain is coerced, arthralgia pain due to rheumatism, muscle arteries and veins contraction, woman's Amenorrhea, alactation, phlegm-heat cough, heat toxin carbuncle swells, anal fistula, oedema, urine is not Profit is had blood in stool, uterine bleeding.《Book on Chinese herbal medicine is just read》：Luffa enters channels and collaterals, solves heat symptoms caused by an exopathgen.Heat is gone except then wind, in network body fluid will not tie combined into Phlegm becomes all diseases of pyogenic infections, the ear therefore cloud detoxifies.Modern medicine study proves：Luffa has therapeutic effect to hepar damnification, and has There are cardiac stimulant diuresis and antitumor effect.
Mother-of-pearl：It is sweet in flavor；It is salty；It is cold in nature.Return liver；The heart channel of Hang-Shaoyin.It is calming the liver；Calm the nerves and calms the frightened；It clears liver and improve vision.It is dizzy to cure mainly headache It is dizzy；Palpitation and insomnia；Demented frightened epilepsy；The hot hot eyes of liver；Pterygium.《Chinese medicine voluminous dictionary》：Nourishing liver is cloudy, clearing away the liver-fire.It controls demented Frightened epilepsy, dizzy, tinnitus, heartbeat, pleuroperitoneum is swollen, women's blood-head, metrorrhagia, the frightened hair convulsion of jerking of children.
Compared with prior art, the present invention having the advantages that：
The present invention selects medicinal material monarch, minister, a left side, keeps all reasons all standby, and pharmacological property is mutually suitable mutually auxiliary, for initiation climacteric sleep disturbance The cause of disease is suited the remedy to the case, tonify the liver and kidney, nourishing yin and nourishing blood, calming the liver, clearing heart fire, mental-tranquilization, blood-enrich, promoting menstruation live The effect of network, inducing astrigency arrest sweating, good absorption effect is significant in efficacy, and it is higher to be cured rate to climacteric sleep disturbance according to clinical verification.
Specific implementation mode
Present invention is further elaborated in following combination specific embodiment.
Embodiment 1
The raw material of effective ingredient of the present invention forms and weight is：
20~40 parts of whorledleaf solomonseal rhizome, 20~40 parts of mulberry fruit, 20~40 parts of bamboo juice, 20~40 parts of arillus longan,
15~30 parts of evergreen mucuna root and leaf, 15~30 parts of Polygonum multiflower knotweed, 15~30 parts of leopard mushroom, 10~25 parts of lotus-seed kernel,
10~25 parts of Huai wheat, 10~25 parts of Semen sesami nigrum, 10~20 parts of Radix Glycyrrhizae, 10~20 parts of the fruit of glossy privet,
9~15 parts of the seed of Oriental arborvitae, 9~15 parts of Radix Rhodiolae Dumulosae, 9~15 parts of twoleaf swertia herb, 6~12 parts of dogwood fruit,
6~12 parts of American Ginseng, 3~9 parts of Radix Polygalae, 3~9 parts of Eleutherococcus Brachypus, 3~9 parts of Herba Lycopi,
3~9 parts of Schisandra chinensis, 3~9 parts of rush, 1~6 part of luffa, 1~4 part of mother-of-pearl.
The processing step of process for preparing medicine of the present invention is：
（1）Whorledleaf solomonseal rhizome, mulberry fruit, arillus longan, evergreen mucuna root and leaf, Schisandra chinensis are put into container, the second of the concentration 80% of 4 times of amounts is added Alcoholic solution impregnates 1-2 hours, heating and refluxing extraction 3-4 hours, and it is spare to obtain filtrate for filtering；
（2）By bamboo juice, Polygonum multiflower knotweed, leopard mushroom, lotus-seed kernel, Huai wheat, Semen sesami nigrum, the fruit of glossy privet, the seed of Oriental arborvitae, Radix Rhodiolae Dumulosae, twoleaf swertia herb, mountain Cornus, American Ginseng, Eleutherococcus Brachypus, Herba Lycopi, rush, mother-of-pearl are put into container, and the 8-10 times of distilled water immersion 4-5 measured is added Hour, heating is boiled 3-4 hours, and immersion liquid is extracted；The 6-8 times of distilled water measured is added again, heating is boiled 2-3 hours, extraction leaching Liquid；The 4-6 times of distilled water measured finally is added, heating is boiled 1-2 hours, and immersion liquid is extracted；Merge immersion liquid three times, filtering must filter Liquid is spare；
（3）Net licorice tablet is taken, cooked honey and a little boiling water is added, it is slightly bored after mixing thoroughly, it sets in frying container, is fried with slow fire depth Yellow is taken out when tack-free, cools, and crushing is ground, and crosses 140 mesh dusting covers, obtains fine powder, spare；
（4）Certain amount of boiling water and even is added with furnacing honey, admixes honey-fried RADIX POLYGALAE, slightly bored, micro- to fry to tack-free as degree, taking-up cools, powder It is broken to grind, 140 mesh dusting covers are crossed, fine powder is obtained, it is spare；
（5）The luffa for being cut into segment is taken, is stirred to yellow degree of being with wheat bran, is taken out, weed out wheat bran, crushing is ground, and 140 mesh are crossed Dusting cover obtains fine powder, spare；
（6）By step（1）, step（2）The filtrate of gained, with step（3）, step（4）, step（5）The fine powder of middle gained adds auxiliary Particle is made in material sucrose and dextrin after mixing, dries, after whole grain, is packaged into the instant particles as Chinese medicine of every bag of 6g.
Usage and dosage：It is oral, 1 bag every time, 2 times a day, morning and evening sub-service, before meals half an hour taken after mixing it with water with boiling water, 7 days are 1 The course for the treatment of takes 6 courses for the treatment of.
Embodiment 2
The raw material of effective ingredient of the present invention forms and weight is：
25~35 parts of whorledleaf solomonseal rhizome, 25~35 parts of mulberry fruit, 25~35 parts of bamboo juice, 25~35 parts of arillus longan,
20~25 parts of evergreen mucuna root and leaf, 20~25 parts of Polygonum multiflower knotweed, 20~25 parts of leopard mushroom, 15~20 parts of lotus-seed kernel,
15~20 parts of Huai wheat, 15~20 parts of Semen sesami nigrum, 14~18 parts of Radix Glycyrrhizae, 14~18 parts of the fruit of glossy privet,
10~13 parts of the seed of Oriental arborvitae, 10~13 parts of Radix Rhodiolae Dumulosae, 10~13 parts of twoleaf swertia herb, 8~10 parts of dogwood fruit,
8~10 parts of American Ginseng, 4~8 parts of Radix Polygalae, 4~8 parts of Eleutherococcus Brachypus, 4~8 parts of Herba Lycopi,
4~6 parts of Schisandra chinensis, 4~6 parts of rush, 1~4 part of luffa, 1~3 part of mother-of-pearl.
The process for preparing medicine processing step and usage and dosage of the present embodiment are same as Example 1.
Embodiment 3
The raw material of effective ingredient of the present invention forms and weight is：
30 parts of whorledleaf solomonseal rhizome, 30 parts of mulberry fruit, 30 parts of bamboo juice, 30 parts of arillus longan,
24 parts of evergreen mucuna root and leaf, 24 parts of Polygonum multiflower knotweed, 24 parts of leopard mushroom, 18 parts of lotus-seed kernel,
18 parts of Huai wheat, 18 parts of Semen sesami nigrum, 16 parts of Radix Glycyrrhizae, 16 parts of the fruit of glossy privet,
12 parts of the seed of Oriental arborvitae, 12 parts of Radix Rhodiolae Dumulosae, 12 parts of twoleaf swertia herb, 9 parts of dogwood fruit,
9 parts of American Ginseng, 6 parts of Radix Polygalae, 6 parts of Eleutherococcus Brachypus, 6 parts of Herba Lycopi,
5 parts of Schisandra chinensis, 5 parts of rush, 3 parts of luffa, 2 parts of mother-of-pearl.
The process for preparing medicine processing step and usage and dosage of the present embodiment are same as Example 1.
Clinical data：
1, case selection
60 clinical observations of climacteric sleep disturbance patient that selection our hospital makes a definite diagnosis, patient are randomly divided into two groups.Treatment group 30 Example, women, 46~57 years old age, average age 49.6 years old, the course of disease most short person 1 month, most elder 3 months are 1.6 months average. Control group 30, women, 47~56 years old age, average age 50.4 years old, the course of disease most short person 1 month, most elder 3 months are average 1.7 months.Two groups of qualifications and record of service are almost the same, and no significant difference is comparable.
2, treatment group patient takes drug of the present invention, take orally, 1 bag every time, 2 times a day, morning and evening sub-service, before meals half an hour with Boiling water is taken after mixing it with water, and 7 days are 1 course for the treatment of, take 6 courses for the treatment of.
Control group patient takes orally estazolam piece（Jinan Yongning Pharmacy stock Co., Ltd produces）, once a day, every time 1-2mg takes before sleeping.
3, efficacy determination：
（1）Recovery from illness：Sleeping time restores normal or Nighttime sleep was at 6 hours or more, and sleep is deep, hale and hearty after waking up.
（2）It improves：Sleep is clearly better, 3 hours sleeping times or more, and Depth of sleep increases.
（3）In vain：Symptom is not improved before treating together.
4, result
16 are cured in treatment group, are improved 10, invalid 4, cure rate 53.3%, total effective rate 86.7%.
8 are cured in control group, are improved 13, no effect 9, cure rate 26.7%, total effective rate 70%.
The above results show that the cure rate and total effective rate for the treatment of group are apparently higher than control group.
Model case is illustrated：
1, room ××, female, 52 years old.Patient's evening difficulty falling asleep, seemingly sleep it is non-sleep, dreaming often and waking easily, wake up after be difficult to fall asleep, later come Institute's interrogation is diagnosed as climacteric sleep disturbance, and after taking 3 courses for the treatment of of Chinese medicine of the present invention, readme symptom is substantially reduced, Sleep quality obviously improves.It follows the doctor's advice after continuing to take 2 courses for the treatment of of Chinese medicine of the present invention, sleeping time restores normal, sleep Deep, hale and hearty after waking up, follow-up is not recurred for 3 months, has been fully recovered.
2, what ××, female, 51 years old.Patient's readme has difficulty in going to sleep after going to bed, and has horrible nightmares more, Yi Xing, night Tidal fever with perspiration, wakes up Easily occur feeling of fatigue afterwards, carry out institute's interrogation later, be diagnosed as climacteric sleep disturbance, through taking 6 treatments of Chinese medicine of the present invention Cheng Hou, sleeping time restore normal, and sleep is deep, and hale and hearty after waking up, follow-up is not recurred for 3 months, has been fully recovered.
Climacteric sleep disturbance is the symptom that climacteric is common and degree is heavier, shows as difficulty of falling asleep, sleep quality Difference, more nightmares and it is timid, sleeping time is short, the ill symptoms such as weak discomfort from morning, this disease cause of disease is mainly the deficiency of liver-yin and kidney-yin, heart kidney It does not hand over, liver-yang hyperactivity, is disturbed in internal heat, symptoms, the Chinese medicines of the present invention such as insomnia is caused to be suited the remedy to the case for the cause of disease, whorledleaf solomonseal rhizome in side, Semen sesami nigrum, the fruit of glossy privet, dogwood fruit, mulberry fruit can tonify the liver and kidney, nourishing yin and nourishing blood；Arillus longan, leopard mushroom can bushing spleen, QI invigorating in side Blood, tranquilizing mind；In side Schisandra chinensis, Radix Polygalae, lotus-seed kernel can kidney calming, kidney of laying one's heart bear, tranquilizing mind；Mother-of-pearl, twoleaf swertia herb can livers in side Checking exuberance of yang, arresting convulsion of calming the nerves；American Ginseng in side, rush, bamboo juice can boosting qi and nourishing yin, clearing heart fires；Polygonum multiflower knotweed, Huai wheat, cypress in side Sub- benevolence, Eleutherococcus Brachypus, Radix Rhodiolae Dumulosae can mental-tranquilization, arrest sweatings；Evergreen mucuna root and leaf, Herba Lycopi, luffa can invigorate blood circulation, stagnation resolvation rows in side Water, clearing and activating the channels and collaterals；Radix Glycyrrhizae can coordinating the drug actions of a prescription in side；All medicines share in side, can play altogether tonify the liver and kidney, nourishing yin and nourishing blood, it is calming the liver, The effect of clearing heart fire, mental-tranquilization, blood-enrich, clearing and activating the channels and collaterals, inducing astrigency arrest sweating, can kidney tonifying clear away heart-fire soothing the liver, adjust kidney, liver, The viscera function of the heart improves sleep state, and good absorption effect is significant in efficacy, is cured according to clinical verification to climacteric sleep disturbance Rate is higher.

Claims (4)

1. a kind of instant particles as Chinese medicine for treating climacteric sleep disturbance, which is characterized in that the original of the effective ingredient is made Material composition and parts by weight are：
20~40 parts of whorledleaf solomonseal rhizome, 20~40 parts of mulberry fruit, 20~40 parts of bamboo juice, 20~40 parts of arillus longan,
15~30 parts of evergreen mucuna root and leaf, 15~30 parts of Polygonum multiflower knotweed, 15~30 parts of leopard mushroom, 10~25 parts of lotus-seed kernel,
10~25 parts of Huai wheat, 10~25 parts of Semen sesami nigrum, 10~20 parts of Radix Glycyrrhizae, 10~20 parts of the fruit of glossy privet,
9~15 parts of the seed of Oriental arborvitae, 9~15 parts of Radix Rhodiolae Dumulosae, 9~15 parts of twoleaf swertia herb, 6~12 parts of dogwood fruit,
6~12 parts of American Ginseng, 3~9 parts of Radix Polygalae, 3~9 parts of Eleutherococcus Brachypus, 3~9 parts of Herba Lycopi,
3~9 parts of Schisandra chinensis, 3~9 parts of rush, 1~6 part of luffa, 1~4 part of mother-of-pearl.
2. a kind of instant particles as Chinese medicine for treating climacteric sleep disturbance according to claim 1, which is characterized in that institute is made The raw material for stating effective ingredient forms and parts by weight are：
25~35 parts of whorledleaf solomonseal rhizome, 25~35 parts of mulberry fruit, 25~35 parts of bamboo juice, 25~35 parts of arillus longan,
20~25 parts of evergreen mucuna root and leaf, 20~25 parts of Polygonum multiflower knotweed, 20~25 parts of leopard mushroom, 15~20 parts of lotus-seed kernel,
15~20 parts of Huai wheat, 15~20 parts of Semen sesami nigrum, 14~18 parts of Radix Glycyrrhizae, 14~18 parts of the fruit of glossy privet,
10~13 parts of the seed of Oriental arborvitae, 10~13 parts of Radix Rhodiolae Dumulosae, 10~13 parts of twoleaf swertia herb, 8~10 parts of dogwood fruit,
8~10 parts of American Ginseng, 4~8 parts of Radix Polygalae, 4~8 parts of Eleutherococcus Brachypus, 4~8 parts of Herba Lycopi,
4~6 parts of Schisandra chinensis, 4~6 parts of rush, 1~4 part of luffa, 1~3 part of mother-of-pearl.
3. a kind of instant particles as Chinese medicine for treating climacteric sleep disturbance according to claim 1, which is characterized in that institute is made The raw material for stating effective ingredient forms and parts by weight are：
30 parts of whorledleaf solomonseal rhizome, 30 parts of mulberry fruit, 30 parts of bamboo juice, 30 parts of arillus longan,
24 parts of evergreen mucuna root and leaf, 24 parts of Polygonum multiflower knotweed, 24 parts of leopard mushroom, 18 parts of lotus-seed kernel,
18 parts of Huai wheat, 18 parts of Semen sesami nigrum, 16 parts of Radix Glycyrrhizae, 16 parts of the fruit of glossy privet,
12 parts of the seed of Oriental arborvitae, 12 parts of Radix Rhodiolae Dumulosae, 12 parts of twoleaf swertia herb, 9 parts of dogwood fruit,
9 parts of American Ginseng, 6 parts of Radix Polygalae, 6 parts of Eleutherococcus Brachypus, 6 parts of Herba Lycopi,
5 parts of Schisandra chinensis, 5 parts of rush, 3 parts of luffa, 2 parts of mother-of-pearl.
4. a kind of instant particles as Chinese medicine for treating climacteric sleep disturbance, which is characterized in that preparation method includes following technique Step：
（1）Whorledleaf solomonseal rhizome, mulberry fruit, arillus longan, evergreen mucuna root and leaf, Schisandra chinensis are put into container, the second of the concentration 80% of 4 times of amounts is added Alcoholic solution impregnates 1-2 hours, heating and refluxing extraction 3-4 hours, and it is spare to obtain filtrate for filtering；
（2）By bamboo juice, Polygonum multiflower knotweed, leopard mushroom, lotus-seed kernel, Huai wheat, Semen sesami nigrum, the fruit of glossy privet, the seed of Oriental arborvitae, Radix Rhodiolae Dumulosae, twoleaf swertia herb, mountain Cornus, American Ginseng, Eleutherococcus Brachypus, Herba Lycopi, rush, mother-of-pearl are put into container, and the 8-10 times of distilled water immersion 4-5 measured is added Hour, heating is boiled 3-4 hours, and immersion liquid is extracted；The 6-8 times of distilled water measured is added again, heating is boiled 2-3 hours, extraction leaching Liquid；The 4-6 times of distilled water measured finally is added, heating is boiled 1-2 hours, and immersion liquid is extracted；Merge immersion liquid three times, filtering must filter Liquid is spare；
（3）Net licorice tablet is taken, cooked honey and a little boiling water is added, it is slightly bored after mixing thoroughly, it sets in frying container, is fried with slow fire depth Yellow is taken out when tack-free, cools, and crushing is ground, and crosses 140 mesh dusting covers, obtains fine powder, spare；
（4）Certain amount of boiling water and even is added with furnacing honey, admixes honey-fried RADIX POLYGALAE, slightly bored, micro- to fry to tack-free as degree, taking-up cools, powder It is broken to grind, 140 mesh dusting covers are crossed, fine powder is obtained, it is spare；
（5）The luffa for being cut into segment is taken, is stirred to yellow degree of being with wheat bran, is taken out, weed out wheat bran, crushing is ground, and 140 mesh are crossed Dusting cover obtains fine powder, spare；
（6）By step（1）, step（2）The filtrate of gained, with step（3）, step（4）, step（5）The fine powder of middle gained adds auxiliary Particle is made in material sucrose and dextrin after mixing, dries, after whole grain, is packaged into the instant particles as Chinese medicine of every bag of 6g.
CN201810938337.5A 2018-08-17 2018-08-17 A kind of instant particles as Chinese medicine and preparation method for treating climacteric sleep disturbance Withdrawn CN108619418A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810938337.5A CN108619418A (en) 2018-08-17 2018-08-17 A kind of instant particles as Chinese medicine and preparation method for treating climacteric sleep disturbance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810938337.5A CN108619418A (en) 2018-08-17 2018-08-17 A kind of instant particles as Chinese medicine and preparation method for treating climacteric sleep disturbance

Publications (1)

Publication Number Publication Date
CN108619418A true CN108619418A (en) 2018-10-09

Family

ID=63708882

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810938337.5A Withdrawn CN108619418A (en) 2018-08-17 2018-08-17 A kind of instant particles as Chinese medicine and preparation method for treating climacteric sleep disturbance

Country Status (1)

Country Link
CN (1) CN108619418A (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104888048A (en) * 2015-06-02 2015-09-09 黄景珍 Traditional Chinese medicine for treating insomnia
CN105012732A (en) * 2015-07-20 2015-11-04 葛翠丽 Traditional Chinese medicine pill for treating sleep disorder syndrome and preparation method thereof
CN105999130A (en) * 2016-08-05 2016-10-12 李玲玲 Traditional Chinese medicinal composition for treating insomnia, and preparation method thereof
CN107095985A (en) * 2017-06-13 2017-08-29 邵竹蕾 A kind of instant particles as Chinese medicine and preparation method for being used to treat that postpartum insomnia is levied

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104888048A (en) * 2015-06-02 2015-09-09 黄景珍 Traditional Chinese medicine for treating insomnia
CN105012732A (en) * 2015-07-20 2015-11-04 葛翠丽 Traditional Chinese medicine pill for treating sleep disorder syndrome and preparation method thereof
CN105999130A (en) * 2016-08-05 2016-10-12 李玲玲 Traditional Chinese medicinal composition for treating insomnia, and preparation method thereof
CN107095985A (en) * 2017-06-13 2017-08-29 邵竹蕾 A kind of instant particles as Chinese medicine and preparation method for being used to treat that postpartum insomnia is levied

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
朱世敏: "六子汤为主治疗更年期综合征", 《上海中医药杂志》 *
陈昆仑: "益气养阴安神法治疗围绝经期睡眠障碍76例临床观察 ", 《新中医》 *
马桂敏: "归脾汤加减配合心理疏导治疗围绝经期失眠", 《光明中医》 *

Similar Documents

Publication Publication Date Title
CN102205107B (en) Chinese medicinal preparation for treating duodenal ulcer and preparation method thereof
CN103520572B (en) A kind of Chinese medicine composition being used for the treatment of atopic dermatitis and preparation method thereof
CN102205108B (en) Traditional Chinese medicine preparation for treating gastric ulcer and preparation method thereof
CN103719493B (en) Siberian solomonseal rhizome health-care tea of a kind of brain-nourishing intelligence-benefiting and preparation method thereof
CN104274754A (en) Traditional Chinese medicine composition for treating infantile enuresis and preparation method of traditional Chinese medicine composition
CN105394282A (en) Radix puerariae health tea capable of reducing blood pressure, blood sugar and blood lipid
CN104971204B (en) A kind of kidney tonifying for coordinating acupuncture and moxibustion therapy nervous tinnitus is had one's ideas straightened out ball and medicinal strip
CN106728130A (en) A kind of Chinese medicine composition and preparation method and its usage for preventing and treating chronic fatigue syndrome
CN105833172A (en) Traditional Chinese medicinal granules for treating asymptomatic myocardial ischemia and preparation method of traditional Chinese medicinal granules
CN106074765A (en) A kind of Chinese medicine composition of sleep of calming the nerves, help
CN106806725A (en) A kind of mulberries facial mask of beautifying whitening
CN108619418A (en) A kind of instant particles as Chinese medicine and preparation method for treating climacteric sleep disturbance
CN104688855B (en) A kind of Chinese goldthread colla corii asini composition for treating chronic fatigue syndrome and its application
CN105012732B (en) Traditional Chinese medicine pill for treating sleep disorder syndrome and preparation method thereof
CN108524861A (en) A kind of traditional Chinese medicinal ointment and preparation method thereof for treating insomnia
CN104223062B (en) Root bark of Chinese wolf-berry health care oral liquid of a kind of reducing pressure and sugar and preparation method thereof
CN103341054B (en) Traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof
CN109464628A (en) A kind of Chinese medicine composition for treating insomnia
CN106620475A (en) Traditional Chinese medicine composition for preventing and treating cognitive disorder caused by diabetes mellitus, and preparation method of traditional Chinese medicine composition
CN115737753A (en) Traditional Chinese medicine composition for beautifying face, removing freckles and improving climacteric symptoms and preparation method thereof
CN104784587A (en) Traditional Chinese medicine composition for treating endocrine disorder type infertility and preparation method thereof
CN104645321A (en) Sugar pills for promoting skeletal development of children and preparation method of sugar pills
CN104162112B (en) A kind of pharmaceutical composition and preparation method thereof
CN104013850A (en) Pharmaceutical composition for relieving malaise after chemoradiotherapy and preparation method thereof
CN104474427A (en) Traditional Chinese medicine for treating child bedwetting and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20181009