CN116531461A - Epidemic prevention and sterilization double coptis chinensis composition oral and nasal spray and preparation method thereof - Google Patents

Epidemic prevention and sterilization double coptis chinensis composition oral and nasal spray and preparation method thereof Download PDF

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Publication number
CN116531461A
CN116531461A CN202211701120.5A CN202211701120A CN116531461A CN 116531461 A CN116531461 A CN 116531461A CN 202211701120 A CN202211701120 A CN 202211701120A CN 116531461 A CN116531461 A CN 116531461A
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China
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extract
parts
double coptis
epidemic prevention
nasal spray
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CN202211701120.5A
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Chinese (zh)
Inventor
梁超峰
杨凤琼
李岩
袁娴
陈红叶
李茜
何永佳
柳又琳
秦春梅
曹志启
尹嵩杰
李依婷
罗燕珊
薛温洛
朱耀驹
黎欣怡
罗雅琳
欧秀红
王冰
陈燕萍
刘晓莉
江锦敏
梁灵花
曾佳怡
王诗莹
郑诗韵
李泽浩
梁芳宁
钟美杏
任咏欢
汤慧琪
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Guangdong Lingnan Institute of Technology
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Guangdong Lingnan Institute of Technology
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Priority to CN202211701120.5A priority Critical patent/CN116531461A/en
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
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Abstract

The invention discloses an epidemic prevention and sterilization double coptis chinensis composition oral-nasal spray and a preparation method thereof, comprising a spray bottle and double coptis chinensis composition, wherein the double coptis chinensis composition is prepared from the following raw materials: honeysuckle extract, baical skullcap root extract, weeping forsythiae extract, passion flower extract, calendula extract, cornflower extract, orchid extract, bisabolol, kurarinone, purslane extract and tea polyphenol. The epidemic prevention and sterilization double coptis composition oral-nasal spray is prepared from raw materials with sterilization effects such as honeysuckle extract, baical skullcap root extract, weeping forsythiae capsule extract, passion flower extract, calendula extract, cornflower extract, orchid extract, purslane extract and the like, can be applied to the oral cavity and the nasal and can continuously kill germs in inhaled air, and a protective net is arranged at the oral cavity and the nasal to protect the health of a human body. The invention has stronger killing effect on various common pathogens and also has inhibiting effect on the transmission of the new coronavirus.

Description

Epidemic prevention and sterilization double coptis chinensis composition oral and nasal spray and preparation method thereof
Technical Field
The invention relates to the technical field of application of traditional Chinese medicines, in particular to an epidemic prevention and sterilization double coptis composition oral and nasal spray and a preparation method thereof.
Background
The Shuanghuanglian is prepared from honeysuckle, baical skullcap root and weeping forsythiae capsule, has the effects of dispelling wind and relieving exterior syndrome, and clearing heat and detoxicating, and is used for treating common cold caused by exogenous wind-heat, and symptoms such as fever, cough and pharyngalgia. Meanwhile, the double coptis chinensis has strong antibacterial and bactericidal effects and has certain effects on common germs. The mouth and nose are used as the respiratory system of human body, the contact with the environment is unavoidable, many infectious diseases are transmitted through air, spray or aerosol, the mouth and nose spray is silent and is inadvisable, the situation that people breathe unsmoothly and the like can be caused by wearing the mask for a long time, and the quality of the mask is different, so that the protection effect is unsatisfactory, therefore, the mouth and nose spray of the Shuanghuanglian composition for epidemic prevention and sterilization and the preparation method thereof are provided.
Disclosure of Invention
The invention aims to overcome the existing defects, provides an epidemic prevention and sterilization double coptis composition oral-nasal spray and a preparation method thereof, adopts honeysuckle extract, baical skullcap root extract and weeping forsythiae extract to compound other raw materials with sterilization effect to prepare the oral-nasal spray which is applied to the oral-nasal spray and can continuously kill germs in inhaled air, and a protective net is arranged at the oral-nasal spray to protect the health of human bodies, so that the problems in the background technology can be effectively solved.
In order to achieve the above purpose, the present invention provides the following technical solutions:
the epidemic prevention and sterilization double coptis chinensis composition oral-nasal spray comprises a spray bottle and double coptis chinensis compositions, wherein the double coptis chinensis compositions are prepared from the following raw materials:
honeysuckle extract, baical skullcap root extract, weeping forsythiae extract, passion flower extract, calendula extract, cornflower extract, orchid extract, bisabolol, kurarinone, purslane extract and tea polyphenol.
Further, the Shuanghuanglian composition is prepared from the following raw materials in parts by weight:
20-30 parts of honeysuckle extract, 10-20 parts of baical skullcap root extract, 10-20 parts of weeping forsythia extract, 8-15 parts of passion flower extract, 5-10 parts of calendula extract, 3-5 parts of cornflower extract, 2-4 parts of orchid extract, 0.4-0.8 part of bisabolol, 0.3-0.6 part of kurarinone, 1-3 parts of purslane extract and 0.03-0.05 part of tea polyphenol.
Further, the Shuanghuanglian composition is prepared from the following raw materials in parts by weight:
20 parts of honeysuckle extract, 20 parts of baical skullcap root extract, 10 parts of weeping forsythia extract, 14 parts of passion flower extract, 5 parts of calendula extract, 5 parts of cornflower extract, 2 parts of orchid extract, 0.7 part of bisabolol, 0.3 part of kurarinone, 3 parts of purslane extract and 0.03 part of tea polyphenol.
Further, the Shuanghuanglian composition is prepared from the following raw materials in parts by weight:
25 parts of honeysuckle extract, 15 parts of baical skullcap root extract, 15 parts of weeping forsythia extract, 12 parts of passion flower extract, 7 parts of calendula extract, 4 parts of cornflower extract, 3 parts of orchid extract, 0.6 part of bisabolol, 0.4 part of kurarinone, 2 parts of purslane extract and 0.04 part of tea polyphenol.
Further, the Shuanghuanglian composition is prepared from the following raw materials in parts by weight:
30 parts of honeysuckle extract, 10 parts of baical skullcap root extract, 20 parts of weeping forsythia extract, 10 parts of passion flower extract, 10 parts of calendula extract, 3 parts of cornflower extract, 4 parts of orchid extract, 0.5 part of bisabolol, 0.6 part of kurarinone, 1 part of purslane extract and 0.05 part of tea polyphenol.
Further, the honeysuckle extract, the baical skullcap root extract, the weeping forsythiae capsule extract, the passion flower extract, the calendula extract, the cornflower extract, the orchid extract and the purslane extract are extracted by ethanol with the concentration of 34-60 percent.
Furthermore, the particle size distribution of the epidemic prevention and sterilization double coptis composition oral-nasal spray is that the percentage of fog drops with the particle size distribution of 2-5 μm to the total volume of the fog drops is more than 75%.
Further, the product is used for disinfection and bacteriostasis at the oral cavity and the nasal cavity, and can prevent bacterial or virus invasion infection.
The preparation method of the epidemic prevention and sterilization double coptis composition oral-nasal spray comprises the following steps:
s1, mixing a honeysuckle extract, a baical skullcap root extract, a weeping forsythia extract, a passion flower extract, a calendula extract, a cornflower extract, an orchid extract and a purslane extract at normal temperature, and homogenizing;
s2, adding bisabolol, kurarinone and tea polyphenol into the mixed solution, and stirring slowly until the mixture is homogeneous;
s3, performing a sampling test, and filling the qualified product into a spray bottle.
In S1 and S2, the stirring speed is 20-40r/min.
Compared with the prior art, the invention has the beneficial effects that: the epidemic prevention and sterilization double coptis composition oral-nasal spray and the preparation method thereof have the following advantages:
the antibacterial raw materials such as honeysuckle extract, baical skullcap root extract, weeping forsythiae extract, passion flower extract, calendula extract, cornflower extract, orchid extract, purslane extract and the like are used for preparing the antibacterial raw materials which are applied to the mouth and nose and can continuously kill germs in inhaled air, and a protective net is arranged at the mouth and nose to protect the health of a human body.
The passion flower extract, calendula extract and cornflower extract are added, so that the bitter taste of the double coptis spray is improved, the whole taste and smell are more acceptable to users, and the Chinese medicinal composition has strong killing effect on various common pathogens and also has inhibiting effect on the transmission of new coronaviruses.
The raw materials are all pure plant sources, so that the use safety is high, and the sterilization effect is good.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The invention provides the following technical scheme:
the epidemic prevention and sterilization double coptis chinensis composition oral-nasal spray comprises a spray bottle and double coptis chinensis compositions, wherein the double coptis chinensis compositions are prepared from the following raw materials:
honeysuckle extract, baical skullcap root extract, weeping forsythiae extract, passion flower extract, calendula extract, cornflower extract, orchid extract, bisabolol, kurarinone, purslane extract and tea polyphenol.
The experiment shows that the honeysuckle has an inhibiting effect on typhoid bacillus, paratyphoid bacillus, escherichia coli, proteus, pseudomonas aeruginosa, pertussis bacillus, vibrio cholerae, staphylococcus, streptococcus, pneumococcus, meningococcus and the like; the honeysuckle extract has remarkable stimulation effect on respiration of drug-resistant staphylococcus aureus plants, and is mainly used for internal medicine and surgical inflammation caused by drug-resistant bacteria, such as treatment of pulmonary tuberculosis complicated with respiratory tract infection, pneumonia, acute bacillary dysentery and diarrhea. It is also used to reduce the loading rate of the throat; radix Scutellariae has antibacterial, antiviral, antiinflammatory, immunity improving, and antipyretic effects; fructus forsythiae has the effects of clearing heat, resolving hard mass, curing scrofula tuberculosis, clearing heart fire, promoting urination, sore and carbuncle, heat stranguria and pain, excessive heat toxin and bacteriostasis and sterilization; passion flower contains tannic acid, has various crude drug components such as plant pectin, tri-glycoside saponin, alkaloid and the like, has astringent effect, and can lubricate and moisten skin, has the effects of moisturizing, preventing skin from cracking and sterilizing; the calendula has the functions of resisting bacteria and diminishing inflammation, can well inhibit the growth and reproduction of bacteria, has the prevention and treatment effects on bacterial infection of various outer skins, such as various inflammations of skin and mucous membrane, and also has the function of diminishing inflammation of otitis; the cornflower can separate 27 kinds of anti-inflammatory triterpene compounds, can treat dermatitis, and has inhibiting effect on induced allergy of skin; can enhance resistance of capillary vessel, inhibit capillary vessel permeability and has antiinflammatory effect; meanwhile, the composition can eliminate free radicals, has oxidation resistance and has the effect of relieving aging; the orchid extract liquid can be taken orally to play roles of moistening lung, promoting diuresis, removing dampness, clearing heat and detoxicating, and can be taken externally to effectively diminish inflammation, inhibit bacteria and promote wound healing.
Example 1:
the epidemic prevention and sterilization double coptis chinensis composition oral-nasal spray comprises a spray bottle and double coptis chinensis compositions, wherein the double coptis chinensis compositions are prepared from the following raw materials in parts by weight:
20 parts of honeysuckle extract, 20 parts of baical skullcap root extract, 10 parts of weeping forsythia extract, 14 parts of passion flower extract, 5 parts of calendula extract, 5 parts of cornflower extract, 2 parts of orchid extract, 0.7 part of bisabolol, 0.3 part of kurarinone, 3 parts of purslane extract and 0.03 part of tea polyphenol.
The preparation method of the epidemic prevention antibactericide double coptis composition oral and nasal spray described in the embodiment 1 comprises the following steps:
s1, mixing a honeysuckle extract, a baical skullcap root extract, a weeping forsythia extract, a passion flower extract, a calendula extract, a cornflower extract, an orchid extract and a purslane extract at normal temperature, homogenizing, and stirring at the speed of 30 r/min;
s2, adding bisabolol, kurarinone and tea polyphenol into the mixed solution, and slowly stirring until the mixture is homogeneous, wherein the stirring speed is 30 r/min;
s3, performing a sampling test, and filling the qualified product into a spray bottle.
Example 2:
the epidemic prevention and sterilization double coptis chinensis composition oral-nasal spray comprises a spray bottle and double coptis chinensis compositions, wherein the double coptis chinensis compositions are prepared from the following raw materials in parts by weight:
25 parts of honeysuckle extract, 15 parts of baical skullcap root extract, 15 parts of weeping forsythia extract, 12 parts of passion flower extract, 7 parts of calendula extract, 4 parts of cornflower extract, 3 parts of orchid extract, 0.6 part of bisabolol, 0.4 part of kurarinone, 2 parts of purslane extract and 0.04 part of tea polyphenol.
The preparation method of the epidemic prevention antibactericide double coptis composition oral and nasal spray described in the embodiment 2 comprises the following steps:
s1, mixing a honeysuckle extract, a baical skullcap root extract, a weeping forsythia extract, a passion flower extract, a calendula extract, a cornflower extract, an orchid extract and a purslane extract at normal temperature, homogenizing, and stirring at the speed of 30 r/min;
s2, adding bisabolol, kurarinone and tea polyphenol into the mixed solution, and slowly stirring until the mixture is homogeneous, wherein the stirring speed is 30 r/min;
s3, performing a sampling test, and filling the qualified product into a spray bottle.
Example 3:
the epidemic prevention and sterilization double coptis chinensis composition oral-nasal spray comprises a spray bottle and double coptis chinensis compositions, wherein the double coptis chinensis compositions are prepared from the following raw materials in parts by weight:
30 parts of honeysuckle extract, 10 parts of baical skullcap root extract, 20 parts of weeping forsythia extract, 10 parts of passion flower extract, 10 parts of calendula extract, 3 parts of cornflower extract, 4 parts of orchid extract, 0.5 part of bisabolol, 0.6 part of kurarinone, 1 part of purslane extract and 0.05 part of tea polyphenol.
The preparation method of the epidemic prevention antibactericide double coptis composition oral and nasal spray described in the embodiment 3 comprises the following steps:
s1, mixing a honeysuckle extract, a baical skullcap root extract, a weeping forsythia extract, a passion flower extract, a calendula extract, a cornflower extract, an orchid extract and a purslane extract at normal temperature, homogenizing, and stirring at the speed of 30 r/min;
s2, adding bisabolol, kurarinone and tea polyphenol into the mixed solution, and slowly stirring until the mixture is homogeneous, wherein the stirring speed is 30 r/min;
s3, performing a sampling test, and filling the qualified product into a spray bottle.
Several test experiments were performed on the epidemic prevention and sterilization Shuanghuanglian composition oral-nasal spray prepared in examples 1-3.
Experimental example 1
Irritation investigation
The irritation inspection was performed on the Shuanghuanglian composition oral-nasal spray prepared in example 1-example 3 by using animal experiments. 40 experimental mice are randomly divided into 4 groups, and the multiple administration mode is the same as the single administration mode, and the continuous administration is carried out at the same part, the administration time and the metering are the same, and the continuous use is carried out for 7 days. Scoring is performed by referring to the skin irritation response scoring standard of the technical guidelines for chemical drug irritation, allergy and hemolysis research, and the average score is calculated, and the result is shown in table 1.
TABLE 1 average score of skin irritation for oral and nasal spray of Shuanghuanglian composition
Experimental results show that the Shuanghuanglian composition oral-nasal spray provided by the invention has a certain stimulation effect on the skin of an experimental mouse, but the irritation is not great and is within a reasonable range.
Experimental example 2
Colibacillus bacteriostasis experiment
The antibacterial effect (antibacterial rate%) of the Shuanghuanglian composition oral-nasal spray prepared in example 1-example 3 on different time nodes of escherichia coli diluted with diluent (PBS) was detected, and the test method was based on: the experimental temperature is 20-22 ℃ according to 2.1.11.3.2 item 2002 of disinfection technical Specification. The results are shown in Table 2.
For 1 minute 2 minutes 3 minutes For 5 minutes For 10 minutes
Example 1 81.79％ 84.26％ 88.37％ 92.63％ 95.18％
Example 2 83.42％ 86.19％ 88.95％ 93.25％ 95.72％
Example 3 82.53％ 85.94％ 91.06％ 92.84％ 95.53％
TABLE 2 antibacterial effect of Shuanghuanglian composition oral-nasal spray on E.coli
Experimental results show that the Shuanghuanglian composition oral-nasal spray has remarkable antibacterial and bactericidal effects on escherichia coli.
The foregoing description is only illustrative of the present invention and is not intended to limit the scope of the invention, and all equivalent structures or equivalent processes or direct or indirect application in other related arts are included in the scope of the present invention.

Claims (10)

1. The epidemic prevention and sterilization double coptis chinensis composition oral-nasal spray is characterized by comprising a spray bottle and a double coptis chinensis composition, wherein the double coptis chinensis composition is prepared from the following raw materials:
honeysuckle extract, baical skullcap root extract, weeping forsythiae extract, passion flower extract, calendula extract, cornflower extract, orchid extract, bisabolol, kurarinone, purslane extract and tea polyphenol.
2. The epidemic prevention and sterilization double coptis composition oral and nasal spray according to claim 1, wherein the double coptis composition is prepared from the following raw materials in parts by weight:
20-30 parts of honeysuckle extract, 10-20 parts of baical skullcap root extract, 10-20 parts of weeping forsythia extract, 8-15 parts of passion flower extract, 5-10 parts of calendula extract, 3-5 parts of cornflower extract, 2-4 parts of orchid extract, 0.4-0.8 part of bisabolol, 0.3-0.6 part of kurarinone, 1-3 parts of purslane extract and 0.03-0.05 part of tea polyphenol.
3. The epidemic prevention and sterilization double coptis composition oral and nasal spray according to claim 2, wherein the double coptis composition is prepared from the following raw materials in parts by weight:
20 parts of honeysuckle extract, 20 parts of baical skullcap root extract, 10 parts of weeping forsythia extract, 14 parts of passion flower extract, 5 parts of calendula extract, 5 parts of cornflower extract, 2 parts of orchid extract, 0.7 part of bisabolol, 0.3 part of kurarinone, 3 parts of purslane extract and 0.03 part of tea polyphenol.
4. The epidemic prevention and sterilization double coptis composition oral and nasal spray according to claim 2, wherein the double coptis composition is prepared from the following raw materials in parts by weight:
25 parts of honeysuckle extract, 15 parts of baical skullcap root extract, 15 parts of weeping forsythia extract, 12 parts of passion flower extract, 7 parts of calendula extract, 4 parts of cornflower extract, 3 parts of orchid extract, 0.6 part of bisabolol, 0.4 part of kurarinone, 2 parts of purslane extract and 0.04 part of tea polyphenol.
5. The epidemic prevention and sterilization double coptis composition oral and nasal spray according to claim 2, wherein the double coptis composition is prepared from the following raw materials in parts by weight:
30 parts of honeysuckle extract, 10 parts of baical skullcap root extract, 20 parts of weeping forsythia extract, 10 parts of passion flower extract, 10 parts of calendula extract, 3 parts of cornflower extract, 4 parts of orchid extract, 0.5 part of bisabolol, 0.6 part of kurarinone, 1 part of purslane extract and 0.05 part of tea polyphenol.
6. The epidemic prevention and sterilization Shuanghuanglian composition oral-nasal spray of claim 1, wherein the honeysuckle extract, the baikal skullcap root extract, the weeping forsythiae capsule extract, the passion flower extract, the calendula extract, the cornflower extract, the orchid extract and the purslane extract are extracted by ethanol with concentration of 34% -60%.
7. The epidemic prevention antibactericide double coptis composition oral and nasal spray of claim 1, wherein the percentage of the fog drops with the particle size distribution of 2-5 μm to the total volume of the fog drops is more than 75%.
8. The epidemic prevention and sterilization double coptis composition oral and nasal spray according to claim 1, which is used for disinfection and bacteriostasis at the oral cavity and nasal cavity and for preventing bacterial or viral invasion infection.
9. The method for preparing the epidemic prevention antibactericide double coptis composition oral and nasal spray according to any one of claims 1 to 8, which is characterized by comprising the following steps:
s1, mixing a honeysuckle extract, a baical skullcap root extract, a weeping forsythia extract, a passion flower extract, a calendula extract, a cornflower extract, an orchid extract and a purslane extract at normal temperature, and homogenizing;
s2, adding bisabolol, kurarinone and tea polyphenol into the mixed solution, and stirring slowly until the mixture is homogeneous;
s3, performing a sampling test, and filling the qualified product into a spray bottle.
10. The method for preparing the epidemic prevention antibactericide double coptis composition oral and nasal spray according to claim 9, wherein in S1 and S2, the stirring speed is 20-40r/min.
CN202211701120.5A 2022-12-28 2022-12-28 Epidemic prevention and sterilization double coptis chinensis composition oral and nasal spray and preparation method thereof Pending CN116531461A (en)

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