CN103169764A - Pharmaceutical composition for treating eczema and preparation method thereof - Google Patents
Pharmaceutical composition for treating eczema and preparation method thereof Download PDFInfo
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- CN103169764A CN103169764A CN2013100689787A CN201310068978A CN103169764A CN 103169764 A CN103169764 A CN 103169764A CN 2013100689787 A CN2013100689787 A CN 2013100689787A CN 201310068978 A CN201310068978 A CN 201310068978A CN 103169764 A CN103169764 A CN 103169764A
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- 201000004624 Dermatitis Diseases 0.000 title claims abstract description 52
- 208000010668 atopic eczema Diseases 0.000 title claims abstract description 51
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 64
- 239000003814 drug Substances 0.000 claims abstract description 51
- 230000000694 effects Effects 0.000 claims abstract description 44
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims abstract description 13
- 241001135917 Vitellaria paradoxa Species 0.000 claims abstract description 13
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 13
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000007765 cera alba Substances 0.000 claims abstract description 12
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims abstract description 12
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 12
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 12
- 229940008099 dimethicone Drugs 0.000 claims abstract description 10
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 10
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 43
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 33
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 33
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 claims description 24
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 18
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims description 16
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims description 16
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- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 claims description 16
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- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 claims description 12
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- WRUGWIBCXHJTDG-UHFFFAOYSA-L magnesium sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=O WRUGWIBCXHJTDG-UHFFFAOYSA-L 0.000 claims description 11
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- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 11
- 239000008213 purified water Substances 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 9
- 229930003427 Vitamin E Natural products 0.000 claims description 9
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 9
- 229940046009 vitamin E Drugs 0.000 claims description 9
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- IJMWOMHMDSDKGK-UHFFFAOYSA-N Isopropyl propionate Chemical compound CCC(=O)OC(C)C IJMWOMHMDSDKGK-UHFFFAOYSA-N 0.000 claims description 8
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims description 8
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- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract description 10
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- 239000004166 Lanolin Substances 0.000 abstract 1
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- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 4
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention belongs to the technical field of medicines, and relates to a pharmaceutical composition for treating eczema and a preparation method thereof. The pharmaceutical composition for treating eczema comprises the following raw materials in parts by weight: 1-3 parts of white beeswax, 10-14 parts of white oil, 3-5 parts of C12-15 benzoate, 1-3 parts of isopropyl myristate, 1-3 parts of lanolin, 2-4 parts of shea butter, 1-3 parts of DC250 dimethicone, 0.1 part of methylparaben, 0.2 part of ethylparaben, 2-4 parts of PEG-30 dipolyhydroxystearate and the like. The pharmaceutical composition for treating eczema has the advantages of quick and strong treatment effect, good maintenance effect, difficult recurrence after healing, itching relieving, inflammation diminishing, sterilization and reduction of the histamine level of eczema skin. Experiments prove that the traditional Chinese medicine composition has ideal treatment effect on symptoms of erythema, skin damage, pruritus and the like of eczema patients.
Description
Technical field
The present invention's medicine technical field relates to a kind of pharmaceutical composition for the treatment of eczema and preparation method thereof.
Background technology
Eczema is a kind ofly to have pleomorphism skin lesion and an easily exudative inflammation reaction by what the endogenous causes of ill such as the patient is hereditary, immune and exopathogenic factor caused, and cardinal symptom is pruritus and skin lesion.
At present, treat the method for eczema both at home and abroad more.For the eczema of pruritus, generally adopt the Therapeutic Method of the partial smearing such as 1% hydrocortisone emulsifiable paste, 0.5% hydrocortisone butyrate ointment, 0.1% Kenac Cream; The patient who causes exudative inflammation for skin lesion smears in conjunction with 2% mupirocin ointment, 0.05% berberine emulsifiable paste, 1% erythromycin ointment, prevents that the Secondary cases antibacterial from infecting.
Owing to adopting external additional glucocorticoid treatment eczema, this class medicine side effect is large, repeated multiple times use, erubescence easily appears, telangiectasis, xerosis cutis, coarse etc., and transferring steroid-dependent dermatitis to, treatment is got up more difficult, has the shortcoming that easily repeatedly occurs.
Summary of the invention
For solving the defective that exists in above-mentioned prior art, the object of the invention is to provide a kind of pharmaceutical composition that has the histamine levels of eczema patients self the skin immunization power that promotes, the ill skin part of reduction and prevent the treatment eczema of disease sites antibacterial infection multiple efficacies.
Technical scheme of the present invention comprises that for a kind of pharmaceutical composition for the treatment of eczema is provided the raw material of following weight portion mixes:
Wherein oil phase component is: the shea butter of the Semen Myristicae bean isopropyl propionate of the white oil of the cera alba of 1-3 part, 10-14 part, the C12-15 benzoate of 3-5 part, 1-3 part, the lanoline of 1-3 part, 2-4 part, the DC250 dimethicone of 1-3 part, the methyl hydroxybenzoate of 0.1 part, the ethyl hydroxybenzoate of 0.2 part, the PEG-30 dimerization hydroxy stearic acid ester of 2-4 part;
The water component is: the purified water of the Magnesium sulfate heptahydrate of the glycerol of 4-6 part, 0.8-1.2 part, the diphhydramine hydrochloride of 0.8-1.2 part, 55-60 part;
Medicine activity component is: the enoxolone of the propylene glycol of 3-5 part, 0-0.5 part, the Mentholum of 0-0.3 part, the paeonol of 0.1 part.
In the pharmaceutical composition of preferred above-mentioned treatment eczema, the weight part ratio of described oil phase component, water component and active component is: 31.8 parts of oil phase component, 64 parts of water components, 4.2 parts of active components.
In the pharmaceutical composition of preferred above-mentioned treatment eczema, comprise oil phase component, water component and the active component of following weight portion:
Wherein oil phase component is: the cera alba of 3 parts, the white oil of 12 parts, the C12-15 benzoate of 4 parts, the Semen Myristicae bean isopropyl propionate of 2 parts, the lanoline of 2 parts, the shea butter of 3 parts, the DC250 dimethicone of 2 parts, the vitamin E of 0.3 part, the methyl hydroxybenzoate of 0.1 part, the ethyl hydroxybenzoate of 0.2 part, the PEG-30 dimerization hydroxy stearic acid ester of 3 parts;
The water component is: the glycerol of 5 parts, the Magnesium sulfate heptahydrate of 1.2 parts, the diphhydramine hydrochloride of 1.0 parts, the purified water of 57 parts;
Medicine activity component is: the propylene glycol of 4 parts, the enoxolone of 0.5 part, the Mentholum of 0.3 part, the paeonol of 0.1 part.
Another technical scheme of the present invention comprises the following steps for a kind of preparation method for the treatment of the pharmaceutical composition of eczema is provided:
1) the oil phase component raw material that takes following weight portion is thrown to the oil phase container to get the cera alba, the white oil of 10-14 part, the C12-15 benzoate of 3-5 part, the Semen Myristicae bean isopropyl propionate of 1-3 part, the lanoline of 1-3 part, the shea butter of 2-4 part, the DC250 dimethicone of 1-3 part, the vitamin E of 0-0.5 part, the methyl hydroxybenzoate of 0.1 part, the ethyl hydroxybenzoate of 0.2 part, the PEG-30 dimerization hydroxy stearic acid ester of 2-4 part of oil mixture A:1-3 part;
The water component raw material that takes following weight portion is thrown to the water container to get the glycerol, the Magnesium sulfate heptahydrate of 0.8-1.2 part, the diphhydramine hydrochloride of 0.8-1.2 part, the purified water of 55-60 part of aqueous mixture B:4-6 part;
The medicine activity component raw material that takes following weight portion is thrown to the medicine activity component container to get the medicine activity component mixture C: the enoxolone of the propylene glycol of 3-5 part, 0-0.5 part, the Mentholum of 0-0.3 part, the paeonol of 0.1 part;
2) respectively oil mixture A is heated to 80-85 ℃, aqueous mixture B is heated to 80-85 ℃,
Pharmaceutically active group container mixture B is heated to 60-65 ℃, stirs respectively in the time of heating, after each mixture reaches said temperature, keeps stirring 30 minutes;
3) to the oil phase container vacuum-pumping, when the vacuum of oil phase container reaches 0.05Mpa, aqueous mixture B is pumped in the oil phase container, add 80-85 ℃ of insulation after mixture B, continue to stir 30 minutes, utilize the high speed homogenization device to carry out homogenizing, the setting rotating speed is 4000rpm, and homogenizing time is 10 minutes;
4) oil water mixture with step 3) gained oil phase container is cooled to 60-65 ℃, slowly adds the good medicine activity component mixture C of dissolving, and insulation continues to stir 20-30 minute to get mixture D;
5) with step 4) mixture D be cooled to 35-40 ℃, utilize the high speed homogenization device to carry out homogenizing,
The setting rotating speed is 4000rpm, and homogenizing time is 10-15 minute; After reaching requirement, the mixture mastic viscosity in the oil phase container goes out the container ageing.
Preferably, in the preparation method of the pharmaceutical composition of above-mentioned treatment eczema, the weight part ratio of oil phase component described in described step 1), water component and active component is: 30-35 part oil phase component, 60-65 part water component, 3.5-5 part active component.
Preferably, in the preparation method of the pharmaceutical composition of above-mentioned treatment eczema, described step 1) is:
The oil phase component raw material that takes following weight portion is thrown to the oil phase container to get the cera alba, the white oil of 12 parts, the C12-15 benzoate of 4 parts, the Semen Myristicae bean isopropyl propionate of 2 parts, the lanoline of 2 parts, the shea butter of 3 parts, the DC250 dimethicone of 2 parts, the vitamin E of 0.3 part, the methyl hydroxybenzoate of 0.1 part, the ethyl hydroxybenzoate of 0.2 part, the PEG-30 dimerization hydroxy stearic acid ester of 3 parts of oil mixture A:3 part;
The water component raw material that takes following weight portion is thrown to the water container to get the glycerol, the Magnesium sulfate heptahydrate of 1.2 parts, the diphhydramine hydrochloride of 1.0 parts, the purified water of 57 parts of aqueous mixture B:5 part;
The medicine activity component raw material that takes following weight portion is thrown to the medicine activity component container to get the medicine activity component mixture C: the propylene glycol of 4 parts, the enoxolone of 0.5 part, the Mentholum of 0.3 part, the paeonol of 0.1 part.
Preferably, in the preparation method of the pharmaceutical composition of above-mentioned treatment eczema, in described step 3), water pumps in the oil phase container with the flow velocity of 1L/ minute, keeps simultaneously oil phase container 500rpm high-speed stirred.
Beneficial effect of the present invention: the pharmaceutical composition for the treatment of eczema of the present invention forms according to the science compatibility, have powerful treatment effect fast, maintenance action is preferably arranged simultaneously, once healing, be difficult for recurrence, have simultaneously itch stopping and diminish inflammation, sterilization and three kinds of effects of reduction eczema skin histamine levels.Be different from the eczema treatment method of external additional glucocorticoid, the pharmaceutical composition that the present invention treats eczema has added class adrenal hormone and adrenotrophic hormone material enoxolone, immunity by eczema patients self skin, promote the mineralocorticoid physiological level of self secreting of skin, thereby play the effect of antipruritic.Through experiment showed, to symptoms such as eczema patients erythema, skin lesion and prurituss to have desirable therapeutic effect.
The specific embodiment
By describing technology contents of the present invention, structural feature in detail, being realized purpose and effect, be explained in detail below in conjunction with embodiment.
Pharmaceutical composition of the present invention has added class adrenal hormone and adrenotrophic hormone material enoxolone, by the immunity of eczema patients self skin, promotes the mineralocorticoid physiological level of self secreting of skin, thereby plays the effect of antipruritic.From in essence, be different from the eczema treatment method of external additional glucocorticoid.
The natural wool fat that Chinese medicine compositions of the present invention is added provides the lipid combination of a complexity for skin, can imitate and strengthen original natural lipid combination function in skin.Lanoline can replenish double-layer of lipoid, and strengthens the barrier function of skin.Be subject to the stimulation of extraneous undesirable element for the skin that prevents eczema, play a protective role.Simultaneously, can repair the eczema damaged skin and resist the infection that damaged skin is avoided antibacterial and fungus.
The shea butter that Chinese medicine compositions of the present invention is added, the most approaching with the indices of human body sebum secretion, be rich in undersaturated fatty acid, strengthen the performance of keeping humidity of skin, can impaired eczema skin be moistened, had simultaneously the damaged part of promotion reepithelialization.
The enoxolone that Chinese medicine compositions of the present invention is added belongs to class adrenal hormone and adrenotrophic hormone material, has the antiinflammatory action of Phenylbutazone or hydrocortisone sample.Enoxolone has all inhibitory action, its antiinflammatory to tire to be about that cortisone or hydrogenation can pine 1/10 to the granuloma induced by implantation of cotton pellets of rat and formaldehyde swelling of the feet, subcutaneous granulomatous inflammation etc.The rat experiment arthritis that the enoxolone on Carrageenan causes has inhibitory action, Cavia porcellus anaphylaxis due to horse serum or egg albumen all there is in various degree inhibitory action, its anti-inflammatory, antianaphylaxis and inhibition capillary permeability, antihistamine or to reduce cell relevant to the reactivity that stimulates.Simultaneously, acute inflammation is had diminish inflammation and the antipruritic effect inhibitory action.
The paeonol that Chinese medicine compositions of the present invention is added has analgesia, antiinflammatory, analgesic and suppress allergic effect.To pressing the pain due to the physics such as tail, acetic acid or chemical factor, has obvious analgesic activity.To by the inflammatory reaction due to carrageenin, Ovum Gallus domesticus album, formaldehyde, histamine, 5-hydroxy tryptamine, Kallidin I, dimethylbenzene and endotoxin etc., has obvious inhibitory action.
The diphenhydramine that Chinese medicine compositions of the present invention is added has the effect of antihistaminic H1 receptor, and nervus centralis is had stronger inhibitory action, prevents irritated allergy.Antipruritic, diminishing inflammation and reducing histamine acts on simultaneously to play the part of in the eczema healing process and has extremely important effect.
Embodiment 1
1) get oil mixture A:2.0 kilogram cera alba, 12.0 kilograms of white oils, 4.0 kilograms of C12-15 benzoate, 2.0 kilograms of isopropyl myristates, 2.0 kilograms of lanolines, 3.0 kilograms of shea butters, 2.0 kilograms of DC250 dimethicones, 0.3 kilogram of vitamin E, 0.1 kilogram of methyl hydroxybenzoate, 0.2 kilogram of ethyl hydroxybenzoate, 3.0 kilograms of PEG-30 dimerization hydroxy stearic acid esters by throwing to the oil phase container hereinafter referred to as each component of heavy oil phase, each component of oil phase is added the oil phase container.
Get aqueous mixture B:5.0 kilogram glycerol, 1.2 kilograms of Magnesium sulfate heptahydrate, 1.0 kilograms of diphhydramine hydrochlorides, 57.0 kilograms of purified water by throwing to the oil phase container hereinafter referred to as each component of heavy water phase, each component of water is added in the water container.
Throw to the medicine activity component container to get the medicine activity component mixture C by the following medicine activity component of weighing: 4.0 kilograms of propylene glycol, 0.5 kilogram of enoxolone, 0.3 Mentholum, 0.1 kilogram of paeonol add medicine activity component in the medicine activity component container.
2) oil mixture A is heated to 80-85 ℃, aqueous mixture B is heated to 80-85 ℃, pharmaceutically active group container mixture B is heated to 60-65 ℃, in the time of heating, stir respectively, after each mixture reaches said temperature, keep stirring 30 minutes;
3) to the oil phase container vacuum-pumping, when the vacuum of oil phase container reaches 0.05Mpa, with aqueous mixture B, pump in the oil phase container with the flow velocity of 1L/ minute, keep simultaneously oil phase container 500rpm high-speed stirred, until the water component materials adds fully; Keep the 500rpm high-speed stirred, continue 30 minutes;
80 ℃, 4000rpm high speed homogenization 10 minutes;
4) continue to keep the 500rpm high-speed stirred, pass into cooling water in oil phase container chuck, be cooled to 60-65 ℃, add the said medicine active component; Keep the 500rpm high-speed stirred, continue 20 minutes;
5) pass into cooling water in oil phase container chuck, be cooled to 35-40 ℃, 4000rpm high speed homogenization 15 minutes according to the viscosity of mastic, is adjusted the operating time of high speed homogenization, the mastic viscosity is on the low side, continue high speed homogenization, after the mastic viscosity reaches requirement, can go out the container ageing, after ageing 12 hours, fill.
Embodiment 2
1) get oil mixture A:1 kilogram cera alba, 10 kilograms of white oils, 3 kilograms of C12-15 benzoate, 1 kilogram of isopropyl myristate, 1 kilogram of lanoline, 2 kilograms of shea butters, 1 kilogram of DC250 dimethicone, 0.3 kilogram of vitamin E, 0.1 kilogram of methyl hydroxybenzoate, 0.2 kilogram of ethyl hydroxybenzoate, 3 kilograms of PEG-30 dimerization hydroxy stearic acid esters by throwing to the oil phase container hereinafter referred to as each component of heavy oil phase, each component of oil phase is added the oil phase container.
Get aqueous mixture B:4 kilogram glycerol, 0.8 kilogram of Magnesium sulfate heptahydrate, 0.8 kilogram of diphhydramine hydrochloride, 55 kilograms of purified water by throwing to the oil phase container hereinafter referred to as each component of heavy water phase, each component of water is added in the water container.
Throw to the medicine activity component container by the following medicine activity component of weighing and get the medicine activity component mixture C: 3 kilograms of propylene glycol, 0.5 kilogram of enoxolone, 0.3 kilogram of Mentholum, 0.1 kilogram of paeonol add medicine activity component in the medicine activity component container.
2) oil mixture A is heated to 80-85 ℃, aqueous mixture B is heated to 80-85 ℃, pharmaceutically active group container mixture B is heated to 60-65 ℃, in the time of heating, stir respectively, after each mixture reaches said temperature, keep stirring 30 minutes;
3) to the oil phase container vacuum-pumping, when the vacuum of oil phase container reaches 0.05Mpa, with aqueous mixture B, pump in the oil phase container with the flow velocity of 1L/ minute, keep simultaneously oil phase container 500rpm high-speed stirred, until the water component materials adds fully; Keep the 500rpm high-speed stirred, continue 30 minutes;
80 ℃, 4000rpm high speed homogenization 10 minutes;
4) continue to keep the 500rpm high-speed stirred, pass into cooling water in oil phase container chuck, be cooled to 60-65 ℃, add the said medicine active component; Keep the 500rpm high-speed stirred, continue 20 minutes;
5) pass into cooling water in oil phase container chuck, be cooled to 35-40 ℃, 4000rpm high speed homogenization 15 minutes according to the viscosity of mastic, is adjusted the operating time of high speed homogenization, the mastic viscosity is on the low side, continue high speed homogenization, after the mastic viscosity reaches requirement, can go out the container ageing, after ageing 12 hours, fill.
Embodiment 3
1) get oil mixture A:3 kilogram cera alba, 14 kilograms of white oils, 5 kilograms of C12-15 benzoate, 3 kilograms of isopropyl myristates, 3 kilograms of lanolines, 4 kilograms of shea butters, 3 kilograms of DC250 dimethicones, 0.5 kilogram of vitamin E, 0.1 kilogram of methyl hydroxybenzoate, 0.2 kilogram of ethyl hydroxybenzoate, 3 kilograms of PEG-30 dimerization hydroxy stearic acid esters by throwing to the oil phase container hereinafter referred to as each component of heavy oil phase, each component of oil phase is added the oil phase container.
Get aqueous mixture B:6 kilogram glycerol, 1.2 kilograms of Magnesium sulfate heptahydrate, 1.2 kilograms of diphhydramine hydrochlorides, 60 kilograms of purified water by throwing to the oil phase container hereinafter referred to as each component of heavy water phase, each component of water is added in the water container.
Throw to the medicine activity component container by the following medicine activity component of weighing and get the medicine activity component mixture C: 5 kilograms of propylene glycol, 0.5 kilogram of enoxolone, 0.3 kilogram of Mentholum, 0.1 kilogram of paeonol add medicine activity component in the medicine activity component container.
2) oil mixture A is heated to 80-85 ℃, aqueous mixture B is heated to 80-85 ℃, pharmaceutically active group container mixture B is heated to 60-65 ℃, in the time of heating, stir respectively, after each mixture reaches said temperature, keep stirring 30 minutes;
3) to the oil phase container vacuum-pumping, when the vacuum of oil phase container reaches 0.05Mpa, with aqueous mixture B, pump in the oil phase container with the flow velocity of 1L/ minute, keep simultaneously oil phase container 500rpm high-speed stirred, until the water component materials adds fully; Keep the 500rpm high-speed stirred, continue 30 minutes;
80 ℃, 4000rpm high speed homogenization 10 minutes;
4) continue to keep the 500rpm high-speed stirred, pass into cooling water in oil phase container chuck, be cooled to 60-65 ℃, add the said medicine active component; Keep the 500rpm high-speed stirred, continue 20 minutes;
5) pass into cooling water in oil phase container chuck, be cooled to 35-40 ℃, 4000rpm high speed homogenization 15 minutes according to the viscosity of mastic, is adjusted the operating time of high speed homogenization, the mastic viscosity is on the low side, continue high speed homogenization, after the mastic viscosity reaches requirement, can go out the container ageing, after ageing 12 hours, fill.
Embodiment 4 the present invention treat the result of use analysis of the pharmaceutical composition of eczema
80 examples be collection have erythema and ooze out skin lesion, with pruritus symptom eczema patients, the patient is divided into 2 groups at random, every group of 40 examples.In 80 routine patients, male 44 examples, female's 36 examples; Age 1-10 year, 3 years old mean age.The course of disease is from 1 week to 1 month; Mainly be distributed in pudendum, buttocks, face.The patient all without significant difference (P〉0.05), has the property of analogy on age, sex, course of disease degree.
Experimental technique
The 1st group of 40 routine eczema patients, skin is first with after the normal saline cleaning of sterilizing, the pharmaceutical composition for preparing in above-described embodiment is smeared at erythema and skin lesion position, every day 2 to 3 times, rehabilitation situation according to eczema skin, erythema disappears, skin lesion has been repaired, just discontinue medication, generally the time of smearing be 3 days to 2 weeks.The 2nd group of 40 routine eczema patients, skin are also first with the normal saline cleaning of sterilization, smear 0.05% Kenac Cream in erythema and skin lesion position, every day 2 to 3 times, and equally according to the rehabilitation situation of skin, the skin rehabilitation, just discontinue medication.Whether after medication 1 month, random access are observed and are recurred by the respondent.
Evaluation criterion
After medication, according to the cross-reference of eczema skin, the erythema of eczema and skin lesion disappear, and namely are judged to be effectively; If after 2 weeks of medication, the erythema of eczema and skin lesion situation do not obtain good change, and it is invalid to be judged to be.The total number of persons that the computational methods of effective percentage %=effectively patient's quantity/this group is investigated.
Experimental result
Through after investigation statistics, the 1st group of 40 routine eczema patients, the number of erythema and skin lesion rehabilitation is 36 people, effective percentage is 90%; The 2nd group of 40 routine eczema patients, the number of rehabilitation is 37 people, effective percentage is 92.5%.
The result of example shows by experiment, and medicine compositions set forth in the present invention to symptoms such as eczema patients erythema, skin lesion and prurituss, has effective rehabilitation efficacy.
The above is only embodiments of the invention; not thereby limit the scope of the claims of the present invention; every equivalent structure or equivalent flow process conversion that utilizes description of the present invention to do; or directly or indirectly be used in other relevant technical fields, all in like manner be included in scope of patent protection of the present invention.
Claims (7)
1. a pharmaceutical composition for the treatment of eczema, is characterized in that, comprises that the raw material of following weight portion mixes:
Wherein oil phase component is: the shea butter of the Semen Myristicae bean isopropyl propionate of the white oil of the cera alba of 1-3 part, 10-14 part, the C12-15 benzoate of 3-5 part, 1-3 part, the lanoline of 1-3 part, 2-4 part, the DC250 dimethicone of 1-3 part, the methyl hydroxybenzoate of 0.1 part, the ethyl hydroxybenzoate of 0.2 part, the PEG-30 dimerization hydroxy stearic acid ester of 2-4 part;
The water component is: the purified water of the Magnesium sulfate heptahydrate of the glycerol of 4-6 part, 0.8-1.2 part, the diphhydramine hydrochloride of 0.8-1.2 part, 55-60 part;
Medicine activity component is: the enoxolone of the propylene glycol of 3-5 part, 0-0.5 part, the Mentholum of 0-0.3 part, the paeonol of 0.1 part.
2. the pharmaceutical composition for the treatment of eczema according to claim 1, is characterized in that, the weight part ratio of described oil phase component, water component and active component is: 31.8 parts of oil phase component, 64 parts of water components, 4.2 parts of active components.
3. the pharmaceutical composition for the treatment of eczema according to claim 1, is characterized in that, comprises oil phase component, water component and the active component of following weight portion:
Wherein oil phase component is: the cera alba of 3 parts, the white oil of 12 parts, the C12-15 benzoate of 4 parts, the Semen Myristicae bean isopropyl propionate of 2 parts, the lanoline of 2 parts, the shea butter of 3 parts, the DC250 dimethicone of 2 parts, the vitamin E of 0.3 part, the methyl hydroxybenzoate of 0.1 part, the ethyl hydroxybenzoate of 0.2 part, the PEG-30 dimerization hydroxy stearic acid ester of 3 parts;
The water component is: the glycerol of 5 parts, the Magnesium sulfate heptahydrate of 1.2 parts, the diphhydramine hydrochloride of 1.0 parts, the purified water of 57 parts;
Medicine activity component is: the propylene glycol of 4 parts, the enoxolone of 0.5 part, the Mentholum of 0.3 part, the paeonol of 0.1 part.
4. a preparation method for the treatment of the pharmaceutical composition of eczema, is characterized in that, comprises the following steps:
1) the oil phase component raw material that takes following weight portion is thrown to the oil phase container to get the cera alba, the white oil of 10-14 part, the C12-15 benzoate of 3-5 part, the Semen Myristicae bean isopropyl propionate of 1-3 part, the lanoline of 1-3 part, the shea butter of 2-4 part, the DC250 dimethicone of 1-3 part, the vitamin E of 0-0.5 part, the methyl hydroxybenzoate of 0.1 part, the ethyl hydroxybenzoate of 0.2 part, the PEG-30 dimerization hydroxy stearic acid ester of 2-4 part of oil mixture A:1-3 part;
The water component raw material that takes following weight portion is thrown to the water container to get the glycerol, the Magnesium sulfate heptahydrate of 0.8-1.2 part, the diphhydramine hydrochloride of 0.8-1.2 part, the purified water of 55-60 part of aqueous mixture B:4-6 part;
The medicine activity component raw material that takes following weight portion is thrown to the medicine activity component container to get the medicine activity component mixture C: the enoxolone of the propylene glycol of 3-5 part, 0-0.5 part, the Mentholum of 0-0.3 part, the paeonol of 0.1 part;
2) respectively oil mixture A is heated to 80-85 ℃, aqueous mixture B is heated to 80-85 ℃, and pharmaceutically active group container mixture B is heated to 60-65 ℃, stirs respectively in the time of heating, after each mixture reaches said temperature, keeps stirring 30 minutes;
3) to the oil phase container vacuum-pumping, when the vacuum of oil phase container reaches 0.05Mpa, aqueous mixture B is pumped in the oil phase container, add 80-85 ℃ of insulation after mixture B, continue to stir 30 minutes, utilize the high speed homogenization device to carry out homogenizing, the setting rotating speed is 4000rpm, and homogenizing time is 10 minutes;
4) oil water mixture with step 3) gained oil phase container is cooled to 60-65 ℃, slowly adds the good medicine activity component mixture C of dissolving, and insulation continues to stir 20-30 minute to get mixture D;
5) with step 4) mixture D be cooled to 35-40 ℃, utilize the high speed homogenization device to carry out homogenizing, the setting rotating speed is 4000rpm, homogenizing time is 10-15 minute; After reaching requirement, the mixture mastic viscosity in the oil phase container goes out the container ageing.
5. the preparation method of the pharmaceutical composition for the treatment of eczema according to claim 4, it is characterized in that, the weight part ratio of oil phase component described in described step 1), water component and active component is: 30-35 part oil phase component, 60-65 part water component, 3.5-5 part active component.
6. the preparation method of the pharmaceutical composition for the treatment of eczema according to claim 4, is characterized in that, described step 1) is:
The oil phase component raw material that takes following weight portion is thrown to the oil phase container to get the cera alba, the white oil of 12 parts, the C12-15 benzoate of 4 parts, the Semen Myristicae bean isopropyl propionate of 2 parts, the lanoline of 2 parts, the shea butter of 3 parts, the DC250 dimethicone of 2 parts, the vitamin E of 0.3 part, the methyl hydroxybenzoate of 0.1 part, the ethyl hydroxybenzoate of 0.2 part, the PEG-30 dimerization hydroxy stearic acid ester of 3 parts of oil mixture A:3 part;
The water component raw material that takes following weight portion is thrown to the water container to get the glycerol, the Magnesium sulfate heptahydrate of 1.2 parts, the diphhydramine hydrochloride of 1.0 parts, the purified water of 57 parts of aqueous mixture B:5 part;
The medicine activity component raw material that takes following weight portion is thrown to the medicine activity component container to get the medicine activity component mixture C: the propylene glycol of 4 parts, the enoxolone of 0.5 part, the Mentholum of 0.3 part, the paeonol of 0.1 part.
7. the preparation method of the pharmaceutical composition for the treatment of eczema according to claim 4, is characterized in that, in described step 3), aqueous mixture B pumps in the oil phase container with the flow velocity of 1L/ minute, keeps simultaneously oil phase container 500rpm high-speed stirred.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906109A (en) * | 2015-04-30 | 2015-09-16 | 柳州立洁科技有限公司 | Infantile eczema cream |
| CN106692161A (en) * | 2016-12-23 | 2017-05-24 | 林维星 | Medicine for treating eczema and preparation method of medicine |
| CN108143646A (en) * | 2018-01-08 | 2018-06-12 | 北京柏雅联合药物研究所有限公司 | A kind of antipruritic cream composition of glycyrrhetinic acid and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856409A (en) * | 2009-04-09 | 2010-10-13 | 江西中医学院 | Medicinal composition for treating skin itch, preparation method and application thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856409A (en) * | 2009-04-09 | 2010-10-13 | 江西中医学院 | Medicinal composition for treating skin itch, preparation method and application thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906109A (en) * | 2015-04-30 | 2015-09-16 | 柳州立洁科技有限公司 | Infantile eczema cream |
| CN106692161A (en) * | 2016-12-23 | 2017-05-24 | 林维星 | Medicine for treating eczema and preparation method of medicine |
| CN108143646A (en) * | 2018-01-08 | 2018-06-12 | 北京柏雅联合药物研究所有限公司 | A kind of antipruritic cream composition of glycyrrhetinic acid and preparation method thereof |
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