CN101849982B - Ointment for treating frostbite rhagadia - Google Patents
Ointment for treating frostbite rhagadia Download PDFInfo
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Abstract
The invention discloses ointment for treating frostbite rhagadia, which comprises the active ingredients of glossy ganoderma extract and cowherb seed extract. The invention also discloses a preparation method of the ointment. The preparation method is technically characterized in that the Chinese medicinal plant of the glossy ganoderma extract (which is equivalent to 0.01 to 9.99g of dried medicinal herbs) and the cowherb seed extract (which is equivalent to 0.01 to 9.99g of the dried medicinal herbs) are mixed in an appropriate ratio, and the ointment is prepared by mixing and stirring the mixture and auxiliary materials such as octadecanol, albolene and the like. The ointment is mainly used for preventing and treating the frostbite rhagadia.
Description
Technical field
The present invention is a kind of Chinese medicinal ointment for control frostbite rhagadia, belongs to the field of Chinese medicines.
Background technology
Cold injury is under certain condition because cold acts on human body, causes damage local and even whole body.People is in cold district work, life due to hungry, tired, field work, or the persistent period is more of a specified duration, and under the conditions such as resisting cold equipment deficiency or footgear discomfort, cold injury often sharply increases cold injury all easily occurs, very large to life, Quality of Life.Occur in large area sleet, the freezing weather in south China at the beginning of the year in the end of the year to 2008 area in 2007, the large area of cold injury produces for the vast disaster area people and participates in numerous people PLA of the freeze proof disaster relief and officers and men People's Armed Police etc. have all caused huge threat.
Ganoderma cold injury Gao Wei produces Beijing XieHe medicine Factory treatment cold injury product without competition, in original prescription, only use Ganoderma extract to add the unguentum of making after the adjuvant mix homogeneously such as white vaseline, octadecanol, this unguentum through drug effect, pharmacological experiment and in Jiangsu, 13 hospital dermatology departments of Beijing, Wuhan three provinces and cities have observed 1225 routine clinical cases altogether, result shows that bursting by freezing cream to chilblain, the curative effect of chapping certainly, clinical total effective rate reaches more than 90%, does not find toxicity.
We are theoretical by Chinese medical discrimination, have increased Semen Vaccariae in original prescription, and the reference for modern traditional Chinese medical science is the theoretical point view because of, pathological study to pernosis, according to existing clinical observation and summary, develop the Chinese medicinal ointment of preventing and treating frostbite rhagadia and write out a prescription.
Summary of the invention
The technical problem that will solve of the present invention is to provide a kind of Chinese medicinal ointment compositions that control frostbite rhagadia is had to good therapeutic effect; By directly spreading upon affected part, reach the object of promoting tissue regeneration and ulcer healing, prevention and treatment cold injury.It has easy to use, curative effect clear and definite, have no side effect, the feature such as drug safety.
For solving technical problem of the present invention, adopt following technical scheme,
The Chinese medicine composition for the treatment of frostbite rhagadia provided by the invention, its active component is comprised of Ganoderma extract and Semen Vaccariae extract.
Wherein, Ganoderma extract and Semen Vaccariae extract part by weight with crude drug count 0.01: 9.99～9.99: 0.01.
Preferred Ganoderma extract and Semen Vaccariae extract part by weight with crude drug count 1: 40～40: 1.
Preferred Ganoderma extract and Semen Vaccariae extract part by weight with crude drug count 1: 4～4: 1.
The unguentum that the present invention also provides above-mentioned Chinese medicine composition to be prepared from.
Every 100 grams of unguentum are comprised of following material:
| Oil phase | Content | Water | Content |
| Octadecanol | 4.0～12.0 grams | Propylene glycol | 2.0～40 grams |
| Stearic acid | 0.5～6.0 gram | Sodium lauryl sulphate | 0.1～8.0 gram |
| Vaseline | 0.5～8.0 gram | Ethyl hydroxybenzoate | 0.1～5.0 gram |
| Liquid paraffin | 0.5～8.0 gram | Ganoderma extract | Be equivalent to 0.1～99.9 gram of crude drug |
| Azone | 0.1～5.0 gram | Semen Vaccariae extract | Be equivalent to 0.1～99.9 gram of crude drug |
| Surplus is water |
For improving the abnormal smells from the patient of unguentum, make patient be easy to accept, unguentum of the present invention also can contain essence.
Preferred every 100 grams of unguentum are comprised of following material:
| Oil phase | Content | Water | Content |
| Octadecanol | 6.0～11.0 grams | Propylene glycol | 10～30 grams |
| Stearic acid | 2.5～6.0 grams | Sodium lauryl sulphate | 1.0～4.0 grams |
| Vaseline | 2.5～7.0 grams | Ethyl hydroxybenzoate | 0.1～3 gram |
| Liquid paraffin | 3.0～6.0 grams | Ganoderma extract | Be equivalent to 1～40 gram of crude drug |
| Azone | 1.0～3.0 grams | Semen Vaccariae extract | Be equivalent to 1～40 gram of crude drug |
| Essence | 0.05～0.20 gram | Surplus is water |
Preferred every 100 grams of unguentum are comprised of following material:
| Oil phase | Content | Water | Content |
| Octadecanol | 7.5～10.5 grams | Propylene glycol | 18～22 grams |
| Stearic acid | 3.5～4.5 grams | Sodium lauryl sulphate | 1.5-2.5 gram |
| Vaseline | 3.5～5.5 grams | Ethyl hydroxybenzoate | 0.5-1.5 gram |
| Liquid paraffin | 3.5～5.5 grams | Ganoderma extract | Be equivalent to 4～16 grams of crude drugs |
| Azone | 1.5～2.5 grams | Semen Vaccariae extract | Be equivalent to 4～16 grams of crude drugs |
| Essence | 0.01-0.10 gram | Surplus is water |
The present invention also provides the method for preparing unguentum of the present invention, comprises the steps:
Semen Vaccariae and Ganoderma extractum are standby by propylene glycol heating for dissolving.The material of oil phase and aqueous portion takes heating for dissolving respectively by recipe quantity, aqueous portion is poured in oil phase and at the uniform velocity stirred, when full and uniform, add the Ganoderma and the Semen Vaccariae extractum solution that have dissolved to continue to stir, make it fully emulsified even, add essence simultaneously; After cooling and get final product.
Wherein Semen Vaccariae and Ganoderma extractum can be commonly used conventional method extraction, preferably use ethanol extraction.
This product is the Chinese medicine of control frostbite rhagadia, and it is O/W emulsifiable paste dosage form, and can be made into specification is that 5～100g/ props up.When using, patient steps on and adopts conventional route of administration to be applied to affected part.
Effect of the present invention, feature and superiority
1, Chinese medical discrimination is theoretical: Semen Vaccariae, and the property of medicine is bitter, flat, energy promoting blood circulation to restore menstrual flow, promoting tissue regeneration and ulcer healing; Ganoderma property is sweet, flat, beneficial empty sore.Both mutually 5, become altogether that beneficial void is stimulated the menstrual flow, the merit of promoting tissue regeneration and ulcer healing.
2, the present invention has increased Chinese medicine Semen Vaccariae in the prescription of existing bursting by freezing cream, and the preliminary pharmacology of process, toxicological experiment result show that the drug action of this unguentum is obvious, estimate that total effective rate will reach more than 90%, have no toxicity.
The specific embodiment:
The following examples are used for further illustrating the present invention, but this and do not mean that any limitation of the invention.
Extract:
1, Ganoderma 1000g is ground into coarse powder, adds ethanol 2000ml and soaks 30 minutes, then add ethanol 6000ml, reflux; Extract altogether three times, add ethanol 8000ml at every turn, extract 2 hours, merge ethanol extract, decompression recycling ethanol.Residue medicinal residues add 60% ethanol extraction three times, and each liquid feeding 8000ml, extracts 1.5 hours, merge extractive liquid,, and decompression recycling ethanol, merges the medicinal liquid of extracted twice, and mix homogeneously concentrates and makes extractum, standby;
2, Semen Vaccariae 1000g is ground into coarse powder, adds 60% ethanol 2000ml and soaks 30 minutes, then add the alcohol reflux of 6000ml 60%.Extract altogether three times, each liquid feeding 8000ml, extracts 2 hours, merge extractive liquid,, and decompression recycling ethanol, concentrates and makes extractum, standby.
Embodiment 1:
| Oil phase | Feed intake | Water | Feed intake |
| Octadecanol | 8g | Propylene glycol | 20g |
| Stearic acid | 3g | Sodium lauryl sulphate | 2g |
| Vaseline | 5g | Ethyl hydroxybenzoate | 1g |
| Liquid paraffin | 5g | Ganoderma | 10g (crude drug) |
| Azone | 2g | Semen Vaccariae | 10g (crude drug) |
| Essence | 0.08g | Water | Add water to 100g |
Preparation method: Semen Vaccariae and Ganoderma extractum are standby by propylene glycol heating for dissolving.The material of oil phase and aqueous portion takes heating for dissolving (approximately 80 ℃ of temperature) respectively by recipe quantity, aqueous portion is poured in oil phase and at the uniform velocity stirred, when full and uniform, add the Ganoderma and the Semen Vaccariae extractum solution that have dissolved to continue to stir, make it fully emulsified even, add essence simultaneously.After cooling mother's salve.
Embodiment 2:
| Oil phase | Feed intake | Water | Feed intake |
| Octadecanol | 9g | Propylene glycol | 20g |
| Stearic acid | 3g | Sodium lauryl sulphate | 2g |
| Vaseline | 4g | Ethyl hydroxybenzoate | 1.5g |
| Liquid paraffin | 5g | Ganoderma | 4g (crude drug) |
| Azone | 2g | Semen Vaccariae | 16g (crude drug) |
| Essence | 0.08g | Water | Add water to 100g |
Preparation method: Semen Vaccariae and Ganoderma extractum are standby by propylene glycol heating for dissolving.The material of oil phase and aqueous portion takes heating for dissolving (approximately 80 ℃ of temperature) respectively by recipe quantity, aqueous portion is poured in oil phase and at the uniform velocity stirred, when full and uniform, add the Ganoderma and the Semen Vaccariae extractum solution that have dissolved to continue to stir, make it fully emulsified even, add essence simultaneously.After cooling mother's salve.
Embodiment 3:
| Oil phase | Feed intake | Water | Feed intake |
| Octadecanol | 8g | Propylene glycol | 20g |
| Stearic acid | 3g | Sodium lauryl sulphate | 2g |
| Vaseline | 5g | Ethyl hydroxybenzoate | 1g |
| Liquid paraffin | 5g | Ganoderma | 8g (crude drug) |
| Azone | 2g | Semen Vaccariae | 12g (crude drug) |
| Essence | 0.08g | Water | Add water to 100g |
Preparation method: Semen Vaccariae and Ganoderma extractum are standby by propylene glycol heating for dissolving.The material of oil phase and aqueous portion takes heating for dissolving (approximately 80 ℃ of temperature) respectively by recipe quantity, aqueous portion is poured in oil phase and at the uniform velocity stirred, when full and uniform, add the Ganoderma and the Semen Vaccariae extractum solution that have dissolved to continue to stir, make it fully emulsified even, add essence simultaneously.After cooling mother's salve.
Embodiment 4:
| Oil phase | Feed intake | Water | Feed intake |
| Octadecanol | 10g | Propylene glycol | 20g |
| Stearic acid | 3g | Sodium lauryl sulphate | 2g |
| Vaseline | 4g | Ethyl hydroxybenzoate | 1g |
| Liquid paraffin | 4g | Ganoderma | 12g (crude drug) |
| Azone | 2g | Semen Vaccariae | 8g (crude drug) |
| Essence | 0.08g | Water | Add water to 100g |
Preparation method: Semen Vaccariae and Ganoderma extractum are standby by propylene glycol heating for dissolving.The material of oil phase and aqueous portion takes heating for dissolving (approximately 80 ℃ of temperature) respectively by recipe quantity, aqueous portion is poured in oil phase and at the uniform velocity stirred, when full and uniform, add the Ganoderma and the Semen Vaccariae extractum solution that have dissolved to continue to stir, make it fully emulsified even, add essence simultaneously.After cooling mother's salve.
Embodiment 5:
| Oil phase | Feed intake | Water | Feed intake |
| Octadecanol | 10g | Propylene glycol | 20g |
| Stearic acid | 3g | Sodium lauryl sulphate | 2g |
| Vaseline | 4g | Ethyl hydroxybenzoate | 1g |
| Liquid paraffin | 4g | Ganoderma | 16g (crude drug) |
| Azone | 2g | Semen Vaccariae | 4g (crude drug) |
| Essence | 0.08g | Water | Add water to 100g |
Preparation method: Semen Vaccariae and Ganoderma extractum are standby by propylene glycol heating for dissolving.The material of oil phase and aqueous portion takes heating for dissolving (approximately 80 ℃ of temperature) respectively by recipe quantity, aqueous portion is poured in oil phase and at the uniform velocity stirred, when full and uniform, add the Ganoderma and the Semen Vaccariae extractum solution that have dissolved to continue to stir, make it fully emulsified even, add essence simultaneously.After cooling mother's salve.
Pharmacological evaluation
Compound ganoderma cold injury cream group is used the unguentum of embodiment 1 preparation.
The impact of test example 1 on part frozen rat whole blood viscosity, factor I, hematocrit and Plasma Viscosity
24 of rats, are divided into normal group, model group, Ganoderma cold injury cream group and compound ganoderma cold injury cream group at random, 4 groups each 6.First at laboratory, adapt to 1 week, then with 1% pentobarbital sodium lumbar injection, be anesthesia shape.5min in-25 ℃ of ethanol is immersed in the following position of the two metapedes ankle joint of rat except normal group, cause the cold-injury models.After moulding, 6h starts the administration of dividing into groups, model group is except changing every day gauze, without any other processing, treatment group is divided into uses Ganoderma cold injury cream, compound ganoderma cold injury cream group, in part, embrocate cold injury cream, every day 3 times, successive administration 48h, after 52h, broken end is got blood examination and is tested: whole blood viscosity (adopting NEX.1 type cone-plate formula blood viscosity meter); Hematocrit and Plasma Viscosity (adopting the blood capillary viscosimeter of 1.5 * 75mm).
Each organizes the testing result of cold injury rat whole blood viscosity, plasma viscosity, hematocrit
N=6, x
on average± s
| Group | Whole blood viscosity (low cutting) (mPas) | Whole blood viscosity (in cut) (mPas) | Whole blood viscosity (height is cut) (mPas) | Packed cell volume % | Plasma viscosity (mPas) |
| Normal group | 15.4±0.7 | 8.9±0.6 | 6.0±0.5 | 45.9± 2.9 | 1.4±0.1 |
| Model group | 20.5±1.1 *1 | 13.0±0.7 *1 | 9.7±0.8 *1 | 58.2± 3.5 *1 | 2.0±0.1 *1 |
| Compound recipe cold injury cream group | 15.8±0.9 *2 | 9.5±0.5 *2 | 6.7±0.8 *2 | 47.5± 3.0 *2 | 1.5±0.1 *2 |
| Ganoderma cold injury cream group | 19.0±0.6 | 10.6±0.6 *2 | 7.8±0.6 *2 | 53.9± 3.1 *3 | 1.8±0.1 *3 |
Note: with normal group comparison,
* 1p < 0.01; With model group comparison,
* 2p < 0.01,
* 3p < 0.05
Result sees the above table, and visible model group whole blood viscosity, hematocrit and 3 levels of Plasma Viscosity are all significantly higher than normal group, and the indices of two administration groups is all starkly lower than model group, and compound ganoderma cold injury cream test group result is excellent compared with Ganoderma cold injury cream group.
The therapeutical effect of 2 pairs of rabbit moderate cold injury of test example
40 of regular grade new zealand rabbits, male and female half and half, are divided into normal group, model group, compound ganoderma cold injury cream group and Ganoderma cold injury cream group at random, 4 groups each 10.By the two metapedes cropping of new zealand rabbit, after local ethanol disinfection, its biped is dipped in the constant temperature cooling bath that-25 ℃ of ethanol are housed, carry out freezing, natural rewarming under room temperature after freezing end.After moulding, 6h starts the administration of dividing into groups, and model group is except changing every day gauze, without any other processing.Treatment group is divided into uses Ganoderma cold injury cream, compound ganoderma cold injury cream group, within the 1st day after cold injury, starts respectively at volume (employing drainage) after 2,3,5,7 days measurement rabbit foot cold injury.Calculate each time period change in volume value, change in volume value/freeze front value * 100% to obtain volume change percentage in arid (freezing front value in 100%), uses change in volume percentage rate as its swelling rate.
Each is organized moderate cold injury rabbit and freezes district's swelling rate testing result
%, x
on average± s,
n＝10
| Group | The 1st day | The 2nd day | The 3rd day | The 5th day | The 7th day |
| Normal group | -- | -- | -- | -- | -- |
| Model group | 227.6±32.1 | 220.3±33.4 | 202.4±35.5 | 188.9±27.7 | 155.3±30.1 |
| Compound recipe cold injury cream group | 228.9±40.7 | 218.4±30.5 | 186.3±29.4 *1 | 139.5±29.3 *1 | 95.8±19.5 *1 |
| Ganoderma cold injury cream group | 225.5±32.3 | 220.5±28.9 | 198.7±30.3 *2 | 152.6±20.7 *1 | 112.5±20.1 *1 |
Note: with model group comparison,
* 1p < 0.01,
* 2p < 0.05.
By upper table, the swelling degree of visible model group and two administration group 2d before treatment changes little, since the 3rd day, the swelling rate of two administration groups starts sharply to decline, to the 7th day, compound recipe cold injury cream group starts to occur portion of tissue loss (< freezes front normal value), and successful is better than Ganoderma cold injury cream.
Each is organized moderate cold injury rabbit and freezes district's work and deposit area testing result
%, x
on average± s, n=10
| Group | The 1st day | The 2nd day | The 3rd day | The 5th day | The 7th day |
| Model group | 18.7±2.1 | 19.0±3.4 | 19.3±2.5 | 20.9±2.7 | 22.1±3.1 |
| Compound recipe cold injury cream group | 18.9±3.1 | 20.3±3.5 *1 | 30.5±4.4 *1 | 44.5±6.1 *1 | 66.8±10.5 *1 |
| Ganoderma cold injury cream group | 19.0±1.7 | 20.4±3.9 *2 | 25.4±4.3 *2 | 35.6±4.7 *1 | 49.5±8.7 *1 |
Note: with model group comparison,
* 1p < 0.01,
* 2p < 0.05.
With image analyzer, measure the work in beginning medication treatment Hou Tuzudong district and deposit area, and calculate to live and deposit area percentage.In the work of Ge Zutudong district, deposit in the testing result of area, can find out treatment before 2d therapeutic effect not obvious, the 3rd, 5,7 days, area was deposited in two administration Zu Tudong district's work and model group comparing difference has significance or utmost point significance.
Test example 3, the preliminary skin irritation test of compound ganoderma cold injury cream
Method: 10 of new zealand rabbits, body weight 2.5kg left and right, male and female half and half, hair outside the buttocks left and right sides is sloughed with depilatory, in left side, without hair position, be coated with substrate (3 centimetres of left and right of diameter), right side is coated with compound ganoderma cold injury cream (diameter is identical) without hair place, every day twice, continuous 20 days.
Result: coating and substrate position are showed no the irritant reaction such as red and swollen, all grow virgin wool.
By above-mentioned theory of Chinese medical science and preliminary pharmacology, pharmacodynamic experiment result, show, the more former Ganoderma cold injury of compound ganoderma cold injury cream curative effect cream therapeutic effect is better, without skin irritation and toxic and side effects.
Claims (3)
1. a Chinese medicine composition for the treatment of frostbite rhagadia, is characterized in that, its active component is comprised of Ganoderma extract and Semen Vaccariae extract; Ganoderma extract and Semen Vaccariae extract part by weight with crude drug count 1: 4～4: 1.
According to claim 1 unguentum, it is characterized in that, every 100 grams of unguentum are comprised of following material:
3. the method for unguentum of preparation claim 2, its feature with, comprise the steps: that Semen Vaccariae and Ganoderma extractum are standby by propylene glycol heating for dissolving; The material of oil phase and aqueous portion takes heating for dissolving respectively by recipe quantity, aqueous portion is poured in oil phase and at the uniform velocity stirred, when full and uniform, add the Ganoderma and the Semen Vaccariae extractum solution that have dissolved to continue to stir, make it fully emulsified even, add essence simultaneously; After cooling and get final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910081120.8A CN101849982B (en) | 2009-04-02 | 2009-04-02 | Ointment for treating frostbite rhagadia |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910081120.8A CN101849982B (en) | 2009-04-02 | 2009-04-02 | Ointment for treating frostbite rhagadia |
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| CN101849982A CN101849982A (en) | 2010-10-06 |
| CN101849982B true CN101849982B (en) | 2014-03-26 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104784243B (en) * | 2015-03-23 | 2018-06-26 | 北京协和药厂 | A kind of application of Chinese medicine composition that can effectively treat frostbite rhagadia in prevention, treatment diabetes |
| CN114949321A (en) * | 2021-02-28 | 2022-08-30 | 中国人民解放军联勤保障部队第九六〇医院 | First-aid dressing for cold area trauma wound and preparation method thereof |
| CN113730410A (en) * | 2021-08-05 | 2021-12-03 | 武汉应内药业有限公司 | Dermatitis ointment and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075418A (en) * | 1992-02-17 | 1993-08-25 | 王纯香 | The Ganoderma protective skin cream |
| CN1163144A (en) * | 1996-04-23 | 1997-10-29 | 孔绍华 | Chinese drug liquid for curing chilblain and scabies |
-
2009
- 2009-04-02 CN CN200910081120.8A patent/CN101849982B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075418A (en) * | 1992-02-17 | 1993-08-25 | 王纯香 | The Ganoderma protective skin cream |
| CN1163144A (en) * | 1996-04-23 | 1997-10-29 | 孔绍华 | Chinese drug liquid for curing chilblain and scabies |
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Address after: 102600 building 7, 37 Yongwang Road, Daxing biomedical industrial base, Zhongguancun Science and Technology Park, Daxing District, Beijing Patentee after: Beijing Xiehe Pharmaceutical Co.,Ltd. Patentee after: NO.302 HOSPITAL OF PLA Address before: 102600 Xingye Road, Daxing District, Beijing Patentee before: Beijing Union Pharmaceutical Factory Patentee before: NO.302 HOSPITAL OF PLA |
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