CN103800841A - Pure traditional Chinese medicine drug for treating women mammary gland proliferation and preparation method thereof - Google Patents
Pure traditional Chinese medicine drug for treating women mammary gland proliferation and preparation method thereof Download PDFInfo
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- CN103800841A CN103800841A CN201410082677.4A CN201410082677A CN103800841A CN 103800841 A CN103800841 A CN 103800841A CN 201410082677 A CN201410082677 A CN 201410082677A CN 103800841 A CN103800841 A CN 103800841A
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Abstract
The invention discloses a pure traditional Chinese medicine drug for treating women mammary gland proliferation. The pure traditional Chinese medicine drug is prepared from following medicinal raw materials in parts by weight: 25-35 parts of cynanchum paniculatum, 20-30 parts of rhizoma sparganii, 25-35 parts of Guangxi curcuma zedoary, 20-30 parts of sculellaria barbata, 20-30 parts of dandelions, 20-30 parts of edible tulips, 20-30 parts of cyperus rotundus, 5-15 parts of sanguis draconis and 2-10 parts of borneol. The pure traditional Chinese medicine drug is prepared according to a formula medicine compatibility principle and has the effects of promoting qi to activate blood, softening hardness to dissipate stagnation, clearing away heat and toxic materials and relieving swelling and pain; the pure traditional Chinese medicine drug is used for treating the women mammary gland proliferation, qi-stagnation and blood stasis and heat toxin internal impedance symptoms. The pure traditional Chinese medicine drug is simple and feasible in production process; a tincture agent is applied to the skin with a wound and can be directly absorbed; the side effects are hardly caused and the quality is stable.
Description
Technical field
The invention belongs to Chinese medicine technical field, particularly a kind of pure Chinese medicine that is used for the treatment of hyperplasia of mammary glands disease and preparation method thereof.
Background technology
Cyclomastopathy is the modal cystic hyperplasia of breast of women, and its sickness rate accounts for the first place of mastopathy.In recent years, this sick sickness rate is ascendant trend year by year, and the age also more and more becomes younger.Approximately there is according to investigations 70%～80% women to have cyclomastopathy in various degree, the highest in women's sickness rate of period of duration.
Along with society is constantly progressive, women has the right of equality, and women also faces the pressure from aspects such as work, life, families simultaneously, causes the factor of mastopathy more and more to present, and clinically has the medicine of significant curative effect less for cyclomastopathy.Pharmaceutical composition of the present invention develops according to Chinese Traditional Medicine and strong medical theory, has national characters.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of pure Chinese medicine that is used for the treatment of hyperplasia of mammary glands disease and preparation method thereof, and this product has promoting flow of QI and blood, hard masses softening and resolving, heat-clearing and toxic substances removing, effect of reducing swelling and alleviating pain.
The present invention is used for the treatment of the pure Chinese medicine of hyperplasia of mammary glands disease, it is made up of following crude drug by weight ratio: Radix Cynanchi Paniculati 25-35 part, Rhizoma Sparganii 20-30 part, Guangxi zedoary 25-35 part, Herba Scutellariae Barbatae 20-30 part, Herba Taraxaci 20-30 part, Pseudobulbus Cremastrae Seu Pleiones 20-30 part, Rhizoma Cyperi 20-30 part, Sanguis Draxonis 5-15 part, Borneolum Syntheticum 2-10 part.
The present invention is used for the treatment of the preparation method of the pure Chinese medicine of hyperplasia of mammary glands disease, comprises following step:
(1) Radix Cynanchi Paniculati, Rhizoma Sparganii, Guangxi zedoary, Herba Scutellariae Barbatae, Herba Taraxaci, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Cyperi 7 taste pulverizing medicinal materials are become to coarse powder, mix, add 80% alcohol dipping percolation slowly after 72 hours, collect percolate;
(2) in percolate, add appropriate 80% ethanol or water, making it contain alcohol amount is 65%～75%, filters, and collects filtrate;
(3) in filtrate, add Sanguis Draxonis and Borneolum Syntheticum, stir, subpackage, gets product.
Medicine of the present invention is a kind of tincture of pure Chinese medicine combination, develops according to Chinese Traditional Medicine and strong medical theory, has national characters.Medicine of the present invention has promoting flow of QI and blood, hard masses softening and resolving, heat-clearing and toxic substances removing, effect of reducing swelling and alleviating pain.Be used for the treatment of hyperplasia of mammary glands disease, qi depression to blood stasis, pyretic toxicity internal resistance card.It is directly applied to pars affecta skin, absorbs soon, and few side effects, production technology is simple, steady quality.
The specific embodiment
Below in conjunction with specific embodiment, the invention will be further described, but not as limitation of the present invention.The part not describing in detail in the present embodiment is to adopt prior art, and industry standard or known approaches.
Embodiment 1
(1) by following weight ratio weighting raw materials: Radix Cynanchi Paniculati 30g, Rhizoma Sparganii 25g, Guangxi zedoary 30g, Herba Scutellariae Barbatae 25g, Herba Taraxaci 25g, Pseudobulbus Cremastrae Seu Pleiones 25g, Rhizoma Cyperi 25g, Sanguis Draxonis 10g, Borneolum Syntheticum 5g;
(2) Radix Cynanchi Paniculati, Rhizoma Sparganii, Guangxi zedoary, Herba Scutellariae Barbatae, Herba Taraxaci, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Cyperi are ground into coarse powder, mix, adding volumetric concentration is 80% ethanol 2400ml dipping percolation slowly after 72 hours, collects percolate;
(3) in percolate, adding volumetric concentration is that 80% ethanol is adjusted to containing alcohol amount to be 70%, to filter, collect filtrate;
(4) in filtrate, add Sanguis Draxonis and Borneolum Syntheticum, stir, subpackage, gets product.
Embodiment 2
(1) by following weight ratio weighting raw materials: Radix Cynanchi Paniculati 35g, Rhizoma Sparganii 30g, Guangxi zedoary 35g, Herba Scutellariae Barbatae 30g, Herba Taraxaci 30g, Pseudobulbus Cremastrae Seu Pleiones 30g, Rhizoma Cyperi 30g, Sanguis Draxonis 15g, Borneolum Syntheticum 8g;
(2) Radix Cynanchi Paniculati, Rhizoma Sparganii, Guangxi zedoary, Herba Scutellariae Barbatae, Herba Taraxaci, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Cyperi are ground into coarse powder, mix, adding volumetric concentration is 80% ethanol 2300ml dipping percolation slowly after 72 hours, collects percolate;
(3) in percolate, adding volumetric concentration is that 80% ethanol is adjusted to containing alcohol amount to be 65%, to filter, collect filtrate;
(4) in filtrate, add Sanguis Draxonis and Borneolum Syntheticum, stir, subpackage, gets product.
Embodiment 3
(1) by following weight ratio weighting raw materials: Radix Cynanchi Paniculati 25g, Rhizoma Sparganii 20g, Guangxi zedoary 25g, Herba Scutellariae Barbatae 20g, Herba Taraxaci 20g, Pseudobulbus Cremastrae Seu Pleiones 20g, Rhizoma Cyperi 20g, Sanguis Draxonis 5g, Borneolum Syntheticum 2g;
(2) Radix Cynanchi Paniculati, Rhizoma Sparganii, Guangxi zedoary, Herba Scutellariae Barbatae, Herba Taraxaci, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Cyperi are ground into coarse powder, mix, adding volumetric concentration is 80% ethanol 2500ml dipping percolation slowly after 72 hours, collects percolate;
(3) in percolate, adding volumetric concentration is that 80% ethanol is adjusted to containing alcohol amount to be 75%, to filter, collect filtrate;
(4) in filtrate, add Sanguis Draxonis and Borneolum Syntheticum, stir, subpackage, gets product.
Experimental result and the clinical observation of application product treatment of the present invention cyclomastopathy below
Experimental result
The embodiment of the present invention 1 product is carried out to percutaneous drug delivery acute toxicity test result of study to be shown: intact skin group and injured skin group are set, every group of 12 white rabbit.Every group is further divided into high dose and low dose group.Low dose group is given clinical plan medicinal liquid, concentration 0.2g crude drug/ml, and dosage 3g crude drug/only.High dose group is given 4 times of concentrated solutions, concentration 0.8g crude drug/ml, and dosage 12g crude drug/only.The administration of 150cm2 skin external application pastille wet tissue, each 15ml.In one day, be total to dispenser 3 times, keep wet tissue moistening by medicinal liquid.Remove wet tissue next day, wash away residual liquor, after the residual medicine of Continuous Observation eccysis 1 hour, 24 hours, 48 hours, 72 hours and the 7th day.The white rabbit of intact skin and injured skin, skin short term contact product of the present invention, eye, mucosa etc. are without significant change, breathe and central nervous system all without poisoning manifestations, agents area skin is without any reaction, after medication in 7 days, whole none death of rabbit.Histopathology shows no obvious abnormalities, therefore medicine of the present invention has no acute toxic reaction.
The embodiment of the present invention 1 product is carried out to long term toxicity test result of study to be shown: low dose group and high dose group are set, every group of 10 rats.Low dose group is given clinical plan medicinal liquid, concentration 0.2g crude drug/ml, and dosage 1g crude drug/only.High dose group is given 4 times of concentrated solutions, concentration 0.8g crude drug/ml, and dosage 4g crude drug/only.16cm2 skin external application administration, each 5ml.Be administered once every day, the drug of topical application 6 hours, administration 6 days weekly, continuous 13 weeks; During administration, have no animal appearance abnormal, the weight of animals, diet and matched group be there was no significant difference relatively.Blood cytology index and matched group comparison when drug withdrawal, there was no significant difference.Serological biochemical markers and matched group comparison, there was no significant difference.Histopathology shows no obvious abnormalities, therefore medicine of the present invention has no long term toxicity reaction, withdrawal time also reacts without delayed toxicity.
The result that adopts the embodiment of the present invention 1 medicine to carry out pharmacodynamic study shows: by the embodiment of the present invention 1 medicine in the local external application of breast, can reduce cyclomastopathy rat model serum estradiol level, reduce the positive glandular cell percent of mammary gland tissue sex hormone receptor, suppress cyclomastopathy, alleviate hyperplasia of mammary lobule reason and change.
Clinical data
1. screening cyclomastopathy 56 examples, are coated with the embodiment of the present invention 1 medicine external to put affected part on the skin, and 3 times on the one 2 months is a course for the treatment of.Through clinical observation on the therapeutic effect good results.Therapeutic effect: cure 23 examples, effective 28 examples, invalid 5 examples, total effective rate 91.1%.
2. screening cyclomastopathy 60 examples, are coated with the embodiment of the present invention 2 medicine externals to put affected part on the skin, and 3 times on the one 2 months is a course for the treatment of.Through clinical observation on the therapeutic effect good results.Therapeutic effect: cure 20 examples, effective 25 examples, invalid 15 examples, total effective rate 75.0%.
3. screening cyclomastopathy 62 examples, are coated with the embodiment of the present invention 3 medicine externals to put affected part on the skin, and 3 times on the one 2 months is a course for the treatment of.Through clinical observation on the therapeutic effect good results.Therapeutic effect: cure 19 examples, effective 25 examples, invalid 18 examples, total effective rate 71.0%.
Claims (2)
1. one kind is used for the treatment of the pure Chinese medicine of hyperplasia of mammary glands disease, it is characterized in that, it is made up of following crude drug by weight ratio: Radix Cynanchi Paniculati 25-35 part, Rhizoma Sparganii 20-30 part, Guangxi zedoary 25-35 part, Herba Scutellariae Barbatae 20-30 part, Herba Taraxaci 20-30 part, Pseudobulbus Cremastrae Seu Pleiones 20-30 part, Rhizoma Cyperi 20-30 part, Sanguis Draxonis 5-15 part, Borneolum Syntheticum 2-10 part.
2. the preparation method that is used for the treatment of according to claim 1 the pure Chinese medicine of hyperplasia of mammary glands disease, is characterized in that, it comprises following step:
(1) Radix Cynanchi Paniculati, Rhizoma Sparganii, Guangxi zedoary, Herba Scutellariae Barbatae, Herba Taraxaci, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Cyperi 7 taste pulverizing medicinal materials are become to coarse powder, mix, add 80% alcohol dipping percolation slowly after 72 hours, collect percolate;
(2) in percolate, add appropriate 80% ethanol or water, making it contain alcohol amount is 65%～75%, filters, and collects filtrate;
(3) in filtrate, add Sanguis Draxonis and Borneolum Syntheticum, stir, subpackage, gets product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410082677.4A CN103800841A (en) | 2014-03-07 | 2014-03-07 | Pure traditional Chinese medicine drug for treating women mammary gland proliferation and preparation method thereof |
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| CN201410082677.4A CN103800841A (en) | 2014-03-07 | 2014-03-07 | Pure traditional Chinese medicine drug for treating women mammary gland proliferation and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106860838A (en) * | 2017-02-15 | 2017-06-20 | 王长杰 | One kind passes through nipple drug treatment female mammary gland disease external application patch |
| CN107137660A (en) * | 2017-05-12 | 2017-09-08 | 黄连启 | A kind of Chinese medicine composition for treating the proliferation of mammary gland |
| CN108553617A (en) * | 2018-04-25 | 2018-09-21 | 四川生命源健康管理有限公司 | The women pleura of anticancer function |
| CN109350720A (en) * | 2018-12-12 | 2019-02-19 | 济南宝和德医药技术有限公司 | A kind of pharmaceutical composition and preparation method thereof relieved pain with blood circulation promoting and dispersing pathogen accumulation, the addiction that disappears |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102233116A (en) * | 2010-04-28 | 2011-11-09 | 成都中医药大学 | Pharmaceutical composition for treating mammary gland proliferation, and preparation method thereof |
| CN102552818A (en) * | 2012-02-15 | 2012-07-11 | 李新民 | External pharmaceutical composition for treating mammary gland diseases and preparation method thereof |
-
2014
- 2014-03-07 CN CN201410082677.4A patent/CN103800841A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102233116A (en) * | 2010-04-28 | 2011-11-09 | 成都中医药大学 | Pharmaceutical composition for treating mammary gland proliferation, and preparation method thereof |
| CN102552818A (en) * | 2012-02-15 | 2012-07-11 | 李新民 | External pharmaceutical composition for treating mammary gland diseases and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 黄建猷，等: "正交试验法优选乳康酊渗漉提取工艺研究", 《中国实验方剂学杂志》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106860838A (en) * | 2017-02-15 | 2017-06-20 | 王长杰 | One kind passes through nipple drug treatment female mammary gland disease external application patch |
| CN107137660A (en) * | 2017-05-12 | 2017-09-08 | 黄连启 | A kind of Chinese medicine composition for treating the proliferation of mammary gland |
| CN108553617A (en) * | 2018-04-25 | 2018-09-21 | 四川生命源健康管理有限公司 | The women pleura of anticancer function |
| CN109350720A (en) * | 2018-12-12 | 2019-02-19 | 济南宝和德医药技术有限公司 | A kind of pharmaceutical composition and preparation method thereof relieved pain with blood circulation promoting and dispersing pathogen accumulation, the addiction that disappears |
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Application publication date: 20140521 |
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