CN108403886A - A kind of Chinese medicine surgery anesthesia agent production method - Google Patents
A kind of Chinese medicine surgery anesthesia agent production method Download PDFInfo
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- 206010002091 Anaesthesia Diseases 0.000 title claims abstract description 48
- 230000037005 anaesthesia Effects 0.000 title claims abstract description 48
- 239000003814 drug Substances 0.000 title claims abstract description 47
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 37
- 238000001356 surgical procedure Methods 0.000 title claims abstract description 37
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 23
- 238000004458 analytical method Methods 0.000 claims abstract description 27
- 238000004806 packaging method and process Methods 0.000 claims abstract description 25
- 238000003860 storage Methods 0.000 claims abstract description 24
- 238000002360 preparation method Methods 0.000 claims abstract description 23
- 235000002566 Capsicum Nutrition 0.000 claims abstract description 18
- 244000246386 Mentha pulegium Species 0.000 claims abstract description 18
- 235000016257 Mentha pulegium Nutrition 0.000 claims abstract description 18
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- 239000006002 Pepper Substances 0.000 claims abstract description 18
- 235000016761 Piper aduncum Nutrition 0.000 claims abstract description 18
- 235000017804 Piper guineense Nutrition 0.000 claims abstract description 18
- 235000008184 Piper nigrum Nutrition 0.000 claims abstract description 18
- 235000001050 hortel pimenta Nutrition 0.000 claims abstract description 18
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- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 17
- 241000758794 Asarum Species 0.000 claims abstract description 17
- 241000269420 Bufonidae Species 0.000 claims abstract description 17
- 241000208296 Datura Species 0.000 claims abstract description 17
- 229940116229 borneol Drugs 0.000 claims abstract description 17
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 17
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000002435 venom Substances 0.000 claims abstract description 17
- 210000001048 venom Anatomy 0.000 claims abstract description 17
- 231100000611 venom Toxicity 0.000 claims abstract description 17
- 238000005070 sampling Methods 0.000 claims abstract description 11
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- 238000012797 qualification Methods 0.000 claims abstract description 6
- 241000722363 Piper Species 0.000 claims description 17
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 15
- 238000000605 extraction Methods 0.000 claims description 13
- 239000012153 distilled water Substances 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000001949 anaesthesia Methods 0.000 claims description 7
- 229940098465 tincture Drugs 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000000645 desinfectant Substances 0.000 claims description 5
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- 230000000144 pharmacologic effect Effects 0.000 abstract description 3
- 244000203593 Piper nigrum Species 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 description 7
- 230000003444 anaesthetic effect Effects 0.000 description 6
- 210000005036 nerve Anatomy 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
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- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 4
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- XFSBVAOIAHNAPC-UHFFFAOYSA-N Aconitin Natural products CCN1CC(C(CC2OC)O)(COC)C3C(OC)C(C(C45)(OC(C)=O)C(O)C6OC)C1C32C4CC6(O)C5OC(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-UHFFFAOYSA-N 0.000 description 2
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- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
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- 229940039750 aconitine Drugs 0.000 description 2
- STDXGNLCJACLFY-UHFFFAOYSA-N aconitine Natural products CCN1CC2(COC)C(O)CC(O)C34C5CC6(O)C(OC)C(O)C(OC(=O)C)(C5C6OC(=O)c7ccccc7)C(C(OC)C23)C14 STDXGNLCJACLFY-UHFFFAOYSA-N 0.000 description 2
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- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 2
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- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
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- 125000002604 borneol group Chemical group 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002695 general anesthesia Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
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- 235000006502 papoula Nutrition 0.000 description 1
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- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
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- A—HUMAN NECESSITIES
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a kind of Chinese medicine surgery anesthesia agent production methods, its composition formula is by datura flower, peppermint, pepper, the dried venom of toads, borneol, asarum, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, fry Southern Star, pappy shell and stir-fry Southern Star are mixed in a certain ratio composition, sampling analysis again, it is filtered after qualification, metering, packaging and storage and etc. made, Chinese medicine surgery anesthesia agent after check analysis is mainly sealed packaging by the packaging by flask for medicinal preparations, the leakproofness of flask for medicinal preparations should be also checked by inspector after packaging, prevent Chinese medicine surgery anesthesia agent from generating leakage, the storage is to carry out the flask for medicinal preparations finished product after packaging into library storage, should also there be the leakproofness production method of the present invention of its finished product of inspector's progress secondary check scientific and reasonable when storage, formula is simple in use, narcoticness is strong, using simple, and pharmacological property is not easy to move back scattered.
Description
Technical field
The present invention relates to anesthetic manufacture technology field, specially a kind of Chinese medicine surgery anesthesia agent production method.
Background technology
Anesthetic refers to making body or body part with drug or non-pharmaceutical method temporarily invertibity being lost consciousness and the pain sensation,
Be chiefly used in the medicament of operation or certain disease treatments, " Chinese anesthesia drugs " be exactly in the world first invent and the anesthetic that uses, by
Outstanding physician Huatuo is created between Eastern Han Dynasty's last years of a dynasty or reign and three states year, 2nd century of Christian era China used " Chinese anesthesia drugs " general anesthesia into
The people of row laparotomy ventrotomy, modern age earliest invention anesthetic,general is the Britain chemist Dai Wei at initial stage in 19th century.
But Chinese medicine surgery anesthesia agent production method currently on the market, formula is complicated in use, and narcoticness is poor, uses
Complexity, and pharmacological property be easy to move back it is scattered.
Invention content
The present invention provides a kind of Chinese medicine surgery anesthesia agent production method, can effectively solve to propose in above-mentioned background technology
Complexity is formulated in use, narcoticness is poor, and using complexity, and pharmacological property is easy to move back scattered problem.
To achieve the above object, the present invention provides the following technical solutions：A kind of Chinese medicine surgery anesthesia agent production method, it is special
Sign is：Its composition formula is by datura flower, peppermint, pepper, the dried venom of toads, borneol, asarum, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, stir-fry Southern Star, opium poppy
Shell and stir-fry Southern Star are mixed in a certain ratio composition, and the formula is made of the raw material of following parts by weight：8-10 parts of datura flower, peppermint
5-7 parts, 6-10 parts of pepper, 5-12 parts of the dried venom of toads, 6-13 parts of borneol, 8-15 parts of asarum, 8-14 parts of Radix Aconiti Kusnezoffii, 6-17 parts of Rhizoma Chuanxiong, fry
5-10 parts of Southern Star, 5-8 parts of pappy shell and 9-15 parts of Southern Star of stir-fry.
According to above-mentioned technical proposal, comprise the following steps that：
(1) disinfectant is smash into juice, impurity screening stays juice, spare；
(2) datura flower, pepper, the dried venom of toads, asarum, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, stir-fry Southern Star, pappy shell and stir-fry Southern Star are put into container
In, it is firstly added 10-15 times and measures, after 60% to 80% alcohol impregnates 1-2 hour, heating is boiled 3-4 hours, extraction；Second
It is secondary plus 8-10 times measure distilled water heating boil 3-4 hour, extraction；For the third time plus 6-8 times is measured distilled water heating and boiled 1-2 hours,
Extraction；Merge extracting solution, it is spare to obtain filtrate for filtration；
(3) borneol and peppermint are ground, obtained 100 targeted fine powders, it is spare；
(4) juice made from step (1)-step (3), filtrate, fine powder and dope mixing, are made liquid, as described
Chinese medicine surgery anesthesia agent；
(5) when carrying out local anaesthesia, only above-mentioned tincture need to be coated in skin surface 10 to 20 minutes.
According to above-mentioned technical proposal, the preparation of the Chinese medicine surgery anesthesia agent production method further includes following steps：Sampling
Filtering, metering, packaging and storage after analysis, qualification.
According to above-mentioned technical proposal, the sampling analysis is acquired and is sent in check analysis room by liquid collector and carried out
Check analysis.
According to above-mentioned technical proposal, it is described packaging mainly by flask for medicinal preparations by the Chinese medicine surgery anesthesia agent after check analysis into
Row packs, and should also check the leakproofness of flask for medicinal preparations by inspector after packaging, prevent Chinese medicine surgery anesthesia agent from generating leakage.
According to above-mentioned technical proposal, the storage is to carry out the flask for medicinal preparations finished product after packaging into library storage, when storage also
There should be inspector to carry out the leakproofness of its finished product of secondary check.
Compared with prior art, beneficial effects of the present invention：Structure of the invention is scientific and reasonable, safe and convenient to use, ocean gold
Flower contains alkaloid, also contains atropine, has the function of that narcotic analgesic, spasmolysis are only jerked, peppermint is pungent, cool, and return lung, Liver Channel have diverging
Wind-heat, soothing liver-qi stagnation and antipruritic and other effects, the dried venom of toads and ingredient have local anesthetic action, and have no stimulation, and pepper has calm work
With the central inhibitory action with the other central nervous system pharmacy of reinforcement, borneol topical application has compared with microstimulation sensory nerve,
There are certain analgesic and mild antisepsis, its volatile oil of asarum to have apparent central inhibitory action, low dose that can make animal
Quiet, taming, autonomic activities are reduced, and large dosage can make animal sleep, and have apparent anticonvulsant action, Radix Aconiti Kusnezoffii aconitine pair
Mucocutaneous sensory nerve ending generates stimulation, have itch, thermal sensation, then inhibit and acted in local anaesthesia, Radix Aconiti Kusnezoffii
Tincture is made with his medicine and fits over external application in plaster for surface anesthesia, or by crude drug, there is narcotic analgesic effect, the curved promoting blood circulation row in river
Gas, wind-expelling pain-stopping fry that Southern Star is micro- pungent gas for pacifying nerve, the peppery and numb tongue of taste, with relieve heat, eliminating the phlegm, relieving convulsion, analgesic
Effect, pappy shell have the function of calming nerves containing a variety of alkaloids, morphine.
Description of the drawings
Attached drawing is used to provide further understanding of the present invention, and a part for constitution instruction, the reality with the present invention
It applies example to be used to explain the present invention together, not be construed as limiting the invention.
In the accompanying drawings：
Fig. 1 is the preparation flow package schematic diagram of the present invention；
Specific implementation mode
Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings, it should be understood that preferred reality described herein
Apply example only for the purpose of illustrating and explaining the present invention and is not intended to limit the present invention.
Embodiment 1：As shown in Figure 1, the present invention provides a kind of Chinese medicine surgery anesthesia agent production method, it is characterised in that：Its
Composite formula is by datura flower, peppermint, pepper, the dried venom of toads, borneol, asarum, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, stir-fry Southern Star, pappy shell and fries Southern Star
It is mixed in a certain ratio composition, the formula is made of the raw material of following parts by weight：8 parts of datura flower, 5 parts of peppermint, 6 parts of pepper,
5 parts of the dried venom of toads, 8 parts of asarum, 8 parts of Radix Aconiti Kusnezoffii, 6 parts of Rhizoma Chuanxiong, fries 5 parts of Southern Star, 5 parts of pappy shell and fries 9 parts of Southern Star 6 parts of borneol.
According to above-mentioned technical proposal, comprise the following steps that：
(1) disinfectant is smash into juice, impurity screening stays juice, spare；
(2) datura flower, pepper, the dried venom of toads, asarum, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, stir-fry Southern Star, pappy shell and stir-fry Southern Star are put into container
In, it is firstly added 10-15 times and measures, after 60% to 80% alcohol impregnates 1-2 hour, heating is boiled 3-4 hours, extraction；Second
It is secondary plus 8-10 times measure distilled water heating boil 3-4 hour, extraction；For the third time plus 6-8 times is measured distilled water heating and boiled 1-2 hours,
Extraction；Merge extracting solution, it is spare to obtain filtrate for filtration；
(3) borneol and peppermint are ground, obtained 100 targeted fine powders, it is spare；
(4) juice made from step (1)-step (3), filtrate, fine powder and dope mixing, are made liquid, as described
Chinese medicine surgery anesthesia agent；
(5) when carrying out local anaesthesia, only above-mentioned tincture need to be coated in skin surface 10 to 20 minutes.
According to above-mentioned technical proposal, the preparation of the Chinese medicine surgery anesthesia agent production method further includes following steps：Sampling
Filtering, metering, packaging and storage after analysis, qualification.
According to above-mentioned technical proposal, the sampling analysis is acquired and is sent in check analysis room by liquid collector and carried out
Check analysis.
According to above-mentioned technical proposal, it is described packaging mainly by flask for medicinal preparations by the Chinese medicine surgery anesthesia agent after check analysis into
Row packs, and should also check the leakproofness of flask for medicinal preparations by inspector after packaging, prevent Chinese medicine surgery anesthesia agent from generating leakage.
According to above-mentioned technical proposal, the storage is to carry out the flask for medicinal preparations finished product after packaging into library storage, when storage also
There should be inspector to carry out the leakproofness of its finished product of secondary check.
Embodiment 2：As shown in Figure 1, the present invention provides a kind of Chinese medicine surgery anesthesia agent production method, it is characterised in that：Its
Composite formula is by datura flower, peppermint, pepper, the dried venom of toads, borneol, asarum, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, stir-fry Southern Star, pappy shell and fries Southern Star
It is mixed in a certain ratio composition, the formula is made of the raw material of following parts by weight：10 parts of datura flower, 7 parts of peppermint, pepper 10
Part, 12 parts of the dried venom of toads, 13 parts of borneol, 15 parts of asarum, 14 parts of Radix Aconiti Kusnezoffii, 17 parts of Rhizoma Chuanxiong fry 10 parts of Southern Star, 8 parts of pappy shell and fry south
15 parts of star.
According to above-mentioned technical proposal, comprise the following steps that：
(1) disinfectant is smash into juice, impurity screening stays juice, spare；
(2) datura flower, pepper, the dried venom of toads, asarum, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, stir-fry Southern Star, pappy shell and stir-fry Southern Star are put into container
In, it is firstly added 10-15 times and measures, after 60% to 80% alcohol impregnates 1-2 hour, heating is boiled 3-4 hours, extraction；Second
It is secondary plus 8-10 times measure distilled water heating boil 3-4 hour, extraction；For the third time plus 6-8 times is measured distilled water heating and boiled 1-2 hours,
Extraction；Merge extracting solution, it is spare to obtain filtrate for filtration；
(3) borneol and peppermint are ground, obtained 100 targeted fine powders, it is spare；
(4) juice made from step (1)-step (3), filtrate, fine powder and dope mixing, are made liquid, as described
Chinese medicine surgery anesthesia agent；
(5) when carrying out local anaesthesia, only above-mentioned tincture need to be coated in skin surface 10 to 20 minutes.
According to above-mentioned technical proposal, the preparation of the Chinese medicine surgery anesthesia agent production method further includes following steps：Sampling
Filtering, metering, packaging and storage after analysis, qualification.
According to above-mentioned technical proposal, the sampling analysis is acquired and is sent in check analysis room by liquid collector and carried out
Check analysis.
According to above-mentioned technical proposal, it is described packaging mainly by flask for medicinal preparations by the Chinese medicine surgery anesthesia agent after check analysis into
Row packs, and should also check the leakproofness of flask for medicinal preparations by inspector after packaging, prevent Chinese medicine surgery anesthesia agent from generating leakage.
According to above-mentioned technical proposal, the storage is to carry out the flask for medicinal preparations finished product after packaging into library storage, when storage also
There should be inspector to carry out the leakproofness of its finished product of secondary check.
Embodiment 3：As shown in Figure 1, the present invention provides a kind of Chinese medicine surgery anesthesia agent production method, it is characterised in that：Its
Composite formula is by datura flower, peppermint, pepper, the dried venom of toads, borneol, asarum, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, stir-fry Southern Star, pappy shell and fries Southern Star
It is mixed in a certain ratio composition, the formula is made of the raw material of following parts by weight：9 parts of datura flower, 6 parts of peppermint, 8 parts of pepper,
11 parts of the dried venom of toads, 10 parts of asarum, 11 parts of Radix Aconiti Kusnezoffii, 15 parts of Rhizoma Chuanxiong, fries 8 parts of Southern Star, 7 parts of pappy shell and fries Southern Star 13 8 parts of borneol
Part.
According to above-mentioned technical proposal, comprise the following steps that：
(1) disinfectant is smash into juice, impurity screening stays juice, spare；
(2) datura flower, pepper, the dried venom of toads, asarum, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, stir-fry Southern Star, pappy shell and stir-fry Southern Star are put into container
In, it is firstly added 10-15 times and measures, after 60% to 80% alcohol impregnates 1-2 hour, heating is boiled 3-4 hours, extraction；Second
It is secondary plus 8-10 times measure distilled water heating boil 3-4 hour, extraction；For the third time plus 6-8 times is measured distilled water heating and boiled 1-2 hours,
Extraction；Merge extracting solution, it is spare to obtain filtrate for filtration；
(3) borneol and peppermint are ground, obtained 100 targeted fine powders, it is spare；
(4) juice made from step (1)-step (3), filtrate, fine powder and dope mixing, are made liquid, as described
Chinese medicine surgery anesthesia agent；
(5) when carrying out local anaesthesia, only above-mentioned tincture need to be coated in skin surface 10 to 20 minutes.
According to above-mentioned technical proposal, the preparation of the Chinese medicine surgery anesthesia agent production method further includes following steps：Sampling
Filtering, metering, packaging and storage after analysis, qualification.
According to above-mentioned technical proposal, the sampling analysis is acquired and is sent in check analysis room by liquid collector and carried out
Check analysis.
According to above-mentioned technical proposal, it is described packaging mainly by flask for medicinal preparations by the Chinese medicine surgery anesthesia agent after check analysis into
Row packs, and should also check the leakproofness of flask for medicinal preparations by inspector after packaging, prevent Chinese medicine surgery anesthesia agent from generating leakage.
According to above-mentioned technical proposal, the storage is to carry out the flask for medicinal preparations finished product after packaging into library storage, when storage also
There should be inspector to carry out the leakproofness of its finished product of secondary check.
Based on above-mentioned, the advantage of the invention is that：Structure of the invention is scientific and reasonable, safe and convenient to use, and datura flower is containing life
Alkaloids also contain atropine, have the function of that narcotic analgesic, spasmolysis are only jerked, peppermint is pungent, cool, and return lung, Liver Channel have diverging wind-heat, dredges
Liver solution is strongly fragrant and antipruritic and other effects, and the dried venom of toads and ingredient have local anesthetic action, and have no stimulation, and pepper has sedation and reinforcement
The central inhibitory action of other central nervous system pharmacy, borneol topical application have compared with microstimulation sensory nerve, have certain
Analgesic and mild antisepsis, its volatile oil of asarum have apparent central inhibitory action, low dose that animal can be made quiet, tame and docile
Clothes, autonomic activities are reduced, and large dosage can make animal sleep, and have apparent anticonvulsant action, and Radix Aconiti Kusnezoffii aconitine is viscous to skin
The sensory nerve ending of film generates stimulation, have itch, thermal sensation, then inhibit and acted in local anaesthesia, Radix Aconiti Kusnezoffii and his medicine
Tincture is made for surface anesthesia, or crude drug is fitted over into external application in plaster, there is narcotic analgesic effect, the curved blood-activating and qi-promoting in river, wind-dispelling
Analgesic, for pacifying nerve, stir-fry Southern Star is micro- to have pungent gas, the peppery and numb tongue of taste to have effects that relieve heat, eliminating the phlegm, relieving convulsion, analgesic, small-mouthed jar
Grain shell has the function of calming nerves containing a variety of alkaloids, morphine.
Finally it should be noted that：The foregoing is merely the preferred embodiments of the present invention, are not intended to restrict the invention, to the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, for those skilled in the art, still can be with
Technical scheme described in the above embodiments is modified or equivalent replacement of some of the technical features.It is all
Within the spirit and principles in the present invention, any modification, equivalent replacement, improvement and so on should be included in the guarantor of the present invention
Within the scope of shield.
Claims (6)
1. a kind of Chinese medicine surgery anesthesia agent production method, it is characterised in that：Its composition formula is by datura flower, peppermint, pepper, toad
Shortcake, asarum, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, fries Southern Star, pappy shell and fries Southern Star and be mixed in a certain ratio composition borneol, it is described be formulated by with
The raw material of lower parts by weight is made：It is 8-10 parts of datura flower, 5-7 parts of peppermint, 6-10 parts of pepper, 5-12 parts of the dried venom of toads, 6-13 parts of borneol, thin
8-15 parts pungent, 8-14 parts of Radix Aconiti Kusnezoffii, 6-17 parts of Rhizoma Chuanxiong fry 5-10 parts of Southern Star, 5-8 parts of pappy shell and fry 9-15 parts of Southern Star.
2. a kind of Chinese medicine surgery anesthesia agent production method according to claim 1, which is characterized in that walked including following technique
Suddenly：
(1) disinfectant is smash into juice, impurity screening stays juice, spare；
(2) datura flower, pepper, the dried venom of toads, asarum, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, stir-fry Southern Star, pappy shell and stir-fry Southern Star are put into container, it is first
It is first added 10-15 times to measure, after 60% to 80% alcohol impregnates 1-2 hour, heating is boiled 3-4 hours, extraction；Second plus 8-
10 times of amount distilled water heating are boiled 3-4 hours, are extracted；For the third time plus 6-8 times is measured distilled water heating and boiled 1-2 hours, is extracted；It closes
And it is spare to obtain filtrate for extracting solution, filtration；
(3) borneol and peppermint are ground, obtained 100 targeted fine powders, it is spare；
(4) juice made from step (1)-step (3), filtrate, fine powder and dope mixing, are made liquid, the as Chinese medicine
Surgery anesthesia agent；
(5) when carrying out local anaesthesia, only above-mentioned tincture need to be coated in skin surface 10 to 20 minutes.
3. a kind of Chinese medicine surgery anesthesia agent production method according to claim 1, which is characterized in that the Chinese medicine operation fiber crops
The preparation of liquor-saturated dose of production method further includes following steps：Filtering, metering, packaging and storage after sampling analysis, qualification.
4. a kind of Chinese medicine surgery anesthesia agent production method according to claim 1, which is characterized in that the sampling analysis is logical
Liquid collector is crossed to acquire and be sent in check analysis room analysis of testing.
5. a kind of Chinese medicine surgery anesthesia agent production method according to claim 1, it is characterised in that：The packaging is main logical
It crosses flask for medicinal preparations and the Chinese medicine surgery anesthesia agent after check analysis is sealed packaging, should also medicament be checked by inspector after packaging
The leakproofness of bottle prevents Chinese medicine surgery anesthesia agent from generating leakage.
6. a kind of Chinese medicine surgery anesthesia agent production method according to claim 1, it is characterised in that：The storage is will to wrap
Flask for medicinal preparations finished product after dress is carried out into library storage, and should also there be the leakproofness that inspector carries out its finished product of secondary check in when storage.
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Cited By (1)
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Application publication date: 20180817 |