CN106109704A - A kind of narcotic analgesic medicine and preparation method thereof - Google Patents
A kind of narcotic analgesic medicine and preparation method thereof Download PDFInfo
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- CN106109704A CN106109704A CN201610776403.4A CN201610776403A CN106109704A CN 106109704 A CN106109704 A CN 106109704A CN 201610776403 A CN201610776403 A CN 201610776403A CN 106109704 A CN106109704 A CN 106109704A
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- narcotic analgesic
- mentholum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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Abstract
The present invention is a kind of narcotic analgesic medicine and preparation method thereof, and its formula includes Venenum Bufonis 10 grams, Flos Daturae 5 grams, Mentholum 10 grams, goes root Herba Asari 10 grams, Radix Aconiti 5 grams, 5 grams of Fructus Piperis, promotees transdermal agent laurocapram 10 milliliters, 75 degree of ethanol 250 milliliters.Its preparation method of a kind of narcotic analgesic medicine, it is characterised in that its step includes: raw material → selection → dedusting → pulverize → enter bottle → alcohol-pickled → rock → filter → preserve.A kind of narcotic analgesic medicine of the present invention and preparation method thereof, advantage is: make simple, and raw material of Chinese medicine has no side effect, has no adverse reaction, can take effect in the short time, reaches the medical purpose of narcotic analgesic.
Description
Technical field
The present invention is a kind of narcotic analgesic medicine and preparation method thereof, belongs to the field of Chinese medicines.
Background technology
Anesthetics refers to make whole body or body local is temporary transient, reversibility is lost consciousness and the medicine of the pain sensation.According to
Its sphere of action general anesthetic and local anesthetic, general anesthetic and local anesthetic can be divided into according to its action character and
Administering mode is different, can be divided into again inhalation anesthetic and intravenous anesthetic.
Prior art discloses Application No.: 201610070120.8 invent a kind of medicine for narcotic analgesic and system
Preparation Method, belongs to the field of Chinese medicines；The raw material of effective ingredient of the present invention consists of: Folium seu Fructus Tarennae, Concha Ostreae, Rhizoma Angiopteridis Fokiensis, Fructus Vitis viniferae, remote
Will, Semen Ziziphi Spinosae, Radix Salviae Miltiorrhizae, Clematis filamentosa Dunn, Paphio-pedilum micranthum Tang et Wang, Bulbus Lilii, Radix Ligustici Brachylobi, Poria cum Radix Pini, Herba Asplenii Incisi, Radix Libanotidis buchotomensis, Rhizoma et radix valerianae and Herba Astragali Melilotoidis；This
Selected by bright medicine, medical material compatibility is suitable, brings out the best in each other, all medicines be harmonious there is heat-clearing and toxic substances removing, analgesia is calmed the nerves, removing obstruction in the collateral to relieve pain, clear away heart-fire profit
The effects such as lung, relaxing muscles and tendons and activating QI and blood in the collateral, mind calming god, all medicines drug effect that is harmonious can directly arrive site of anesthesia, has in clinical operation is treated
Significantly narcotic analgesic effect, and instant effect, have no side effect, safe ready, low price, easily prepare, it is a kind of preferable
Local anesthesia product.
Summary of the invention
The deficiency existed for prior art, it is an object of the present invention to provide a kind of narcotic analgesic medicine, and its formula includes toad
Crisp 10 grams, Flos Daturae 5 grams, Mentholum 10 grams, goes root Herba Asari 10 grams, Radix Aconiti 5 grams, 5 grams of Fructus Piperis, promotees transdermal agent laurocapram 10
Milliliter, 75 degree of ethanol 250 milliliters.Its preparation method of a kind of narcotic analgesic medicine, it is characterised in that its step includes: raw material
→ selection → dedusting → pulverize → enter bottle → alcohol-pickled → rock → filter → preserve:
Step one: raw material, prepare Venenum Bufonis more than 10 grams, Flos Daturae more than 5 grams, Mentholum is more than 10 grams, goes root Herba Asari more than 10
Gram, Radix Aconiti is more than 5 grams, and Fructus Piperis is more than 5 grams, laurocapram 10 milliliters；
Step 2: select, denitrogenate outside ketone, selected Venenum Bufonis 10 grams, Flos Daturae 5 grams, Mentholum 10 grams, goes to root Herba Asari 10 grams, raw river
Crow 5 grams, 5 grams of Fructus Piperis；
Step 3: dedusting, by selected Venenum Bufonis, Flos Daturae, Mentholum, removes root Herba Asari, Radix Aconiti, and Fructus Piperis puts into pulverizing dust removal machine
Carry out dedusting；
Step 4: pulverize, by putting into the pulverizing Venenum Bufonis of dust removal machine, Flos Daturae, Mentholum, removes root Herba Asari, Radix Aconiti, Fructus Piperis powder
Broken, take out mixed-powder；
Step 5: enter bottle, pours dry dustless vial into by the mixed-powder of taking-up；
Step 6: alcohol-pickled, pours 75 degree of ethanol 250 milliliters, constant temperature 40～42 DEG C into, soaks 6～8 days；
Step 7: rock, rocks vial every day once, one time 3-5 minute, intersects the most counterclockwise and rocks, observes solution
Uniform color is not stratified；
Step 8: filter, with clean antiseptic gauze filtration residue；
Step 9: preserving, filtering solution loads clean air-tight bottle, temperature control is stored in 10～40 DEG C.
Further, described step steady Venenum Bufonis more than 10 grams, Flos Daturae more than 5 grams, Mentholum is more than 10 grams, removes root
Herba Asari is more than 10 grams, and Radix Aconiti is more than 5 grams, and Fructus Piperis is more than 5 grams, takes Venenum Bufonis 20 grams, Flos Daturae 10 grams, Mentholum 20 grams, removes root
Herba Asari 20 grams, Radix Aconiti 10 grams, 10 grams of Fructus Piperis is suitable.
Further, the alcohol-pickled constant temperature of described step 6 40～42 DEG C, soak and within 6～8 days, take constant temperature 41 DEG C, soak 7 days
For properly.
Further, described step 7 is rocked one time 3-5 minute, and it is suitable for taking 4 minutes.
Further, described step 9 temperature control is stored in 10～40 DEG C and takes 25 DEG C is optimal.
A kind of narcotic analgesic medicine of the present invention and preparation method thereof, advantage is: make simple, raw material of Chinese medicine, without secondary
Effect, has no adverse reaction, can take effect in the short time, reach the medical purpose of narcotic analgesic.
Detailed description of the invention
For the technological means making the present invention realize, creation characteristic, reach purpose and be easy to understand with effect, below in conjunction with
Detailed description of the invention, is expanded on further the present invention.
The present invention provides a kind of narcotic analgesic medicine, and its formula includes Venenum Bufonis 10 grams, Flos Daturae 5 grams, Mentholum 10 grams, goes
Root Herba Asari 10 grams, Radix Aconiti 5 grams, 5 grams of Fructus Piperis, promote transdermal agent laurocapram 10 milliliters, 75 degree of ethanol 250 milliliters.A kind of anesthesia
Its preparation method of analgesic drug product, it is characterised in that its step includes: raw material → selection → dedusting → pulverize → enter bottle → ethanol
Soak → rock → filter → preserve:
Step one: raw material, prepare Venenum Bufonis more than 10 grams, Flos Daturae more than 5 grams, Mentholum is more than 10 grams, goes root Herba Asari more than 10
Gram, Radix Aconiti is more than 5 grams, and Fructus Piperis is more than 5 grams, laurocapram 10 milliliters；
Step 2: select, denitrogenate outside ketone, selected Venenum Bufonis 10 grams, Flos Daturae 5 grams, Mentholum 10 grams, goes to root Herba Asari 10 grams, raw river
Crow 5 grams, 5 grams of Fructus Piperis；
Step 3: dedusting, by selected Venenum Bufonis, Flos Daturae, Mentholum, removes root Herba Asari, Radix Aconiti, and Fructus Piperis puts into pulverizing dust removal machine
Carry out dedusting；
Step 4: pulverize, by putting into the pulverizing Venenum Bufonis of dust removal machine, Flos Daturae, Mentholum, removes root Herba Asari, Radix Aconiti, Fructus Piperis powder
Broken, take out mixed-powder；
Step 5: enter bottle, pours dry dustless vial into by the mixed-powder of taking-up；
Step 6: alcohol-pickled, pours 75 degree of ethanol 250 milliliters, constant temperature 40～42 DEG C into, soaks 6～8 days；
Step 7: rock, rocks vial every day once, one time 3-5 minute, intersects the most counterclockwise and rocks, observes solution
Uniform color is not stratified；
Step 8: filter, with clean antiseptic gauze filtration residue；
Step 9: preserving, filtering solution loads clean air-tight bottle, temperature control is stored in 10～40 DEG C.
Described step steady Venenum Bufonis more than 10 grams, Flos Daturae more than 5 grams, Mentholum is more than 10 grams, goes root Herba Asari to be more than
10 grams, Radix Aconiti is more than 5 grams, and Fructus Piperis is more than 5 grams, takes Venenum Bufonis 20 grams, Flos Daturae 10 grams, Mentholum 20 grams, removes root Herba Asari 20 grams,
Radix Aconiti 10 grams, 10 grams of Fructus Piperis is suitable, and the alcohol-pickled constant temperature of described step 6 40～42 DEG C soak and take constant temperature 41 in 6～8 days
DEG C, it 7 days is suitable for soaking, and described step 7 is rocked one time 3-5 minute, and it is suitable for taking 4 minutes, and described step 9 temperature control is stored in
10～40 DEG C take 25 DEG C is optimal.
A kind of narcotic analgesic medicine of the present invention and preparation method thereof, advantage is: make simple, raw material of Chinese medicine, without secondary
Effect, has no adverse reaction, can take effect in the short time, reach the medical purpose of narcotic analgesic.
The ultimate principle of the present invention and principal character and advantages of the present invention are more than shown and described, for this area skill
For art personnel, it is clear that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and without departing substantially from the present invention spirit or
In the case of basic feature, it is possible to realize the present invention in other specific forms.Therefore, no matter from the point of view of which point, all should be by
Embodiment regards exemplary as, and is nonrestrictive, the scope of the present invention by claims rather than on state
Bright restriction, it is intended that include all changes fallen in the implication of equivalency and scope of claim in the present invention
In.
Although moreover, it will be appreciated that this specification is been described by according to embodiment, but the most each embodiment only wraps
Containing an independent technical scheme, this narrating mode of description is only that for clarity sake those skilled in the art should
Description can also be formed those skilled in the art through appropriately combined as an entirety, the technical scheme in each embodiment
May be appreciated other embodiments.
Claims (6)
1. a narcotic analgesic medicine, its formula includes Venenum Bufonis 10 grams, Flos Daturae 5 grams, Mentholum 10 grams, removes root Herba Asari 10 grams,
Radix Aconiti 5 grams, 5 grams of Fructus Piperis, promote transdermal agent laurocapram 10 milliliters, 75 degree of ethanol 250 milliliters.
2. the preparation method of a narcotic analgesic medicine, it is characterised in that its step includes: raw material → selection → dedusting → pulverizing
→ enter bottle → alcohol-pickled → rock → filter → preserve:
Step one: raw material, prepare Venenum Bufonis more than 10 grams, Flos Daturae more than 5 grams, Mentholum is more than 10 grams, goes root Herba Asari more than 10
Gram, Radix Aconiti is more than 5 grams, and Fructus Piperis is more than 5 grams, laurocapram 10 milliliters；Step 2: select, denitrogenate outside ketone, selected Venenum Bufonis 10
Gram, Flos Daturae 5 grams, Mentholum 10 grams, go root Herba Asari 10 grams, Radix Aconiti 5 grams, 5 grams of Fructus Piperis；
Step 3: dedusting, by selected Venenum Bufonis, Flos Daturae, Mentholum, removes root Herba Asari, Radix Aconiti, and Fructus Piperis puts into pulverizing dust removal machine
Carry out dedusting；
Step 4: pulverize, by putting into the pulverizing Venenum Bufonis of dust removal machine, Flos Daturae, Mentholum, removes root Herba Asari, Radix Aconiti, Fructus Piperis powder
Broken, take out mixed-powder；
Step 5: enter bottle, pours dry dustless vial into by the mixed-powder of taking-up；
Step 6: alcohol-pickled, pours 75 degree of ethanol 250 milliliters, constant temperature 40～42 DEG C into, soaks 6～8 days；
Step 7: rock, rocks vial every day once, one time 3-5 minute, intersects the most counterclockwise and rocks, observes solution
Uniform color is not stratified；
Step 8: filter, with clean antiseptic gauze filtration residue；
Step 9: preserving, filtering solution loads clean air-tight bottle, temperature control is stored in 10～40 DEG C.
A kind of narcotic analgesic medicine the most according to claim 1 and preparation method thereof, it is characterised in that: described step is surely
Standby Venenum Bufonis more than 10 grams, Flos Daturae more than 5 grams, Mentholum is more than 10 grams, goes root Herba Asari more than 10 grams, and Radix Aconiti is more than 5 grams, recklessly
Green pepper is more than 5 grams, takes Venenum Bufonis 20 grams, Flos Daturae 10 grams, Mentholum 20 grams, removes root Herba Asari 20 grams, Radix Aconiti 10 grams, and 10 grams of Fructus Piperis is
Properly.
A kind of narcotic analgesic medicine the most according to claim 1 and preparation method thereof, it is characterised in that: described step 6 wine
Essence soaks constant temperature 40～42 DEG C, soaks and within 6～8 days, takes constant temperature 41 DEG C, and it 7 days is suitable for soaking.
A kind of narcotic analgesic medicine the most according to claim 1 and preparation method thereof, it is characterised in that: described step 7 is shaken
Shaking one time 3-5 minute, it is suitable for taking 4 minutes.
A kind of narcotic analgesic medicine the most according to claim 1 and preparation method thereof, it is characterised in that: described step 9 temperature
It is optimal that control be stored in 10～40 DEG C to take 25 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610776403.4A CN106109704A (en) | 2016-08-31 | 2016-08-31 | A kind of narcotic analgesic medicine and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610776403.4A CN106109704A (en) | 2016-08-31 | 2016-08-31 | A kind of narcotic analgesic medicine and preparation method thereof |
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| CN106109704A true CN106109704A (en) | 2016-11-16 |
Family
ID=57273255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201610776403.4A Pending CN106109704A (en) | 2016-08-31 | 2016-08-31 | A kind of narcotic analgesic medicine and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106860708A (en) * | 2017-03-09 | 2017-06-20 | 牡丹江医学院 | A kind of composite anaesthetic and preparation method thereof |
| CN107551096A (en) * | 2017-09-15 | 2018-01-09 | 安徽农业大学 | A kind of Chinese medicine composition for Animal Anesthesia and preparation method thereof |
| CN108403886A (en) * | 2018-05-10 | 2018-08-17 | 无锡市人民医院 | A kind of Chinese medicine surgery anesthesia agent production method |
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| CN101357116A (en) * | 2007-08-03 | 2009-02-04 | 谭国梁 | Transdermal and transmucosal local narcotic analgesic and preparation method of gel formulation thereof |
| CN101366888A (en) * | 2008-10-06 | 2009-02-18 | 徐冬梅 | Antalgica wine |
| CN103071002A (en) * | 2012-12-24 | 2013-05-01 | 唐雅蓉 | Traditional Chinese medicine with anesthetic effect |
| CN104491256A (en) * | 2014-12-30 | 2015-04-08 | 青岛市肿瘤医院 | Multi-effect local anesthetic |
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2016
- 2016-08-31 CN CN201610776403.4A patent/CN106109704A/en active Pending
Patent Citations (5)
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|---|---|---|---|---|
| CN101357116A (en) * | 2007-08-03 | 2009-02-04 | 谭国梁 | Transdermal and transmucosal local narcotic analgesic and preparation method of gel formulation thereof |
| CN101129640A (en) * | 2007-08-22 | 2008-02-27 | 常换领 | Medicine for reliving inflammation and pain |
| CN101366888A (en) * | 2008-10-06 | 2009-02-18 | 徐冬梅 | Antalgica wine |
| CN103071002A (en) * | 2012-12-24 | 2013-05-01 | 唐雅蓉 | Traditional Chinese medicine with anesthetic effect |
| CN104491256A (en) * | 2014-12-30 | 2015-04-08 | 青岛市肿瘤医院 | Multi-effect local anesthetic |
Non-Patent Citations (1)
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| 赵应征 主编: "《生物药物制剂学》", 30 June 2011, 浙江大学出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106860708A (en) * | 2017-03-09 | 2017-06-20 | 牡丹江医学院 | A kind of composite anaesthetic and preparation method thereof |
| CN107551096A (en) * | 2017-09-15 | 2018-01-09 | 安徽农业大学 | A kind of Chinese medicine composition for Animal Anesthesia and preparation method thereof |
| CN108403886A (en) * | 2018-05-10 | 2018-08-17 | 无锡市人民医院 | A kind of Chinese medicine surgery anesthesia agent production method |
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Application publication date: 20161116 |