CN104352726A - Wet tissue with effects of activating blood circulation, dispersing stasis and relieving swellings and pain - Google Patents
Wet tissue with effects of activating blood circulation, dispersing stasis and relieving swellings and pain Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a wet tissue with the effects of activating blood circulation, dispersing stasis and relieving swellings and pain and relates to technical field of wet tissue production. The wet tissue consists of a wet tissue matrix and a base solution attached to the matrix, wherein the base solution is prepared from the following raw materials in parts by mass: 50-65 parts of pseudo-ginseng, 30-40 parts of curculigo sinensis, 30-35 parts of dipsacus asper, 20-30 parts of murraya, 20-25 parts of pink reineckea herb, 15-20 parts of claoxylon polot merr, 15-20 parts of sappanwood, 10-15 parts of semen vaccariae, 15-25 parts of gendarussa vulgaris, 10-15 parts of garden balsam stem, 5-10 parts of notopterygium root, 10-15 parts of magnoliae officinalis, 5-10 parts of scarlet kadsura root and 5-10 parts of cortex periplocae. The wet tissue with the effects of activating blood circulation, dispersing stasis and relieving swellings and pain is prepared by using natural Chinese herbal medicines as raw materials, and the medicinal ingredients enter the body from the skin, and can perform a local therapeutic effect and achieve the purpose of treating the whole body. The wet tissue rapidly takes effect, does not have adverse reaction, and is convenient to carry and use.
Description
Technical field:
The present invention relates to wet tissue production technical field, be specifically related to a kind of wet tissue with promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect.
Background technology:
In daily life, people can meet with acute closed property soft tissue sprain because of a variety of causes unavoidably, dampen the disease such as local swelling, pain, livid purple, ecchymosis fracture caused.At present, the medicine used clinically has bone-setting liquor, repercussive and analgesic tincture and gram grieved liniment etc., although these medicines are made by Chinese herbal medicine, has certain curative effect during use, but its promoting blood circulation to remove blood stasis and reducing swelling and alleviating pain effect undesirable, and onset slow, hold time shorter, the course for the treatment of is longer.In addition, due to these medicines be all fill in container bottle, carry and use inconvenience, not especially being suitable for the crowd of frequent travel.
Summary of the invention:
The wet tissue that technical problem to be solved by this invention is to provide a kind of nonirritant, evident in efficacy and preparation method simply has promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect.
Technical problem to be solved by this invention adopts following technical scheme to realize:
Have the wet tissue of promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect, be made up of wet tissue matrix and the base fluid be adsorbed on matrix, described base fluid is made up of the raw material of following quality proportioning:
Radix Notoginseng 50-65 part, Rhizoma Curculiginis (processed with wine) 30-40 part, Radix Dipsaci 30-35 part, Folium Et Cacumen Murrayae 20-30 part, Herba Reineckeae Carneae 20-25 part, five tastes rattan 15-20 part, Lignum Sappan 15-20 part, ring stay row 10-15 part, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 15-25 part, Herba speranskiae tuberculatae 10-15 part, Rhizoma Et Radix Notopterygii 5-10 part, Cortex Magnoliae Officinalis 10-15 part, kadsura root 5-10 part, Cortex Periplocae 5-10 part.
The optimization formula of described base fluid is: Radix Notoginseng 60 parts, Rhizoma Curculiginis (processed with wine) 35 parts, Radix Dipsaci 30 parts, Folium Et Cacumen Murrayae 25 parts, Herba Reineckeae Carneae 22 parts, 18 parts, five tastes rattan, Lignum Sappan 15 parts, ring stay row 12 parts, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 20 parts, Herba speranskiae tuberculatae 13 parts, Rhizoma Et Radix Notopterygii 8 parts, Cortex Magnoliae Officinalis 10 parts, kadsura root 8 parts, Cortex Periplocae 6 parts.
There is the preparation method of wet tissue of promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect, comprise the following steps:
(1) dry after first above-mentioned medical material being cleaned, then take each medical material in proportion, respectively by its dozen of powder, cross 40 mesh sieves, then by all medicated powder mixing after sieving;
(2) mixed powder is joined in ultrasonic extraction tank, then add the ethanol that volumetric concentration is 80%-90%, through three supersound extraction, filtration, merging filtrate;
(3) filtrate decompression Distillation recovery ethanol to purity step (2) prepared is 60%-65%, and after leaving standstill 12-24h subsequently, filtering precipitates, and gained filtrate is base fluid;
(4) wet tissue matrix is immersed in base fluid, after suctioning base fluid, take out wet tissue matrix, after ultraviolet radiation sterilization, wet tissue is loaded in the supporting plastic bag of sterilizing, seal and obtain wet tissue finished product.
The weight ratio of described medicated powder and ethanol is 1:15-25.
The operating temperature of described ultrasonic extraction tank is room temperature, and operating frequency is 40KW, and each extraction time is 30-45min.
The invention has the beneficial effects as follows: the present invention adopts natural Chinese medicinal herb composition to be raw material, the obtained wet tissue with promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect, active ingredient enters health through skin, can play local therapeutic effects, can reach again the object for the treatment of whole body; Onset speed is fast, has no untoward reaction, and carries with easy to use.
Detailed description of the invention:
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1
A kind of wet tissue with promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect, be made up of wet tissue matrix and the base fluid be adsorbed on matrix, described base fluid is made up of the raw material of following quality proportioning: Radix Notoginseng 50 parts, Rhizoma Curculiginis (processed with wine) 30 parts, Radix Dipsaci 30 parts, Folium Et Cacumen Murrayae 20 parts, Herba Reineckeae Carneae 20 parts, 15 parts, five tastes rattan, Lignum Sappan 15 parts, ring stay row 10 parts, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 15 parts, Herba speranskiae tuberculatae 10 parts, Rhizoma Et Radix Notopterygii 5 parts, Cortex Magnoliae Officinalis 10 parts, kadsura root 5 parts, Cortex Periplocae 5 parts.
Dry after first above-mentioned medical material being cleaned, then take each medical material in proportion, respectively by its dozen of powder, cross 40 mesh sieves, then by all medicated powder mixing after sieving; Joined by mixed powder in ultrasonic extraction tank, then add the ethanol that volumetric concentration is 80%-90%, the weight ratio of medicated powder and ethanol is 1:25, through three supersound extraction, (Extracting temperature is room temperature, frequency is 40KW, and each extraction time is 45min), filter, merging filtrate; Be 60%-65% by filtrate decompression Distillation recovery ethanol to the purity of preparation, leave standstill filtering precipitation after 15h subsequently, gained filtrate is base fluid; Wet tissue matrix is immersed in base fluid, after suctioning base fluid, takes out wet tissue matrix, after ultraviolet radiation sterilization, wet tissue is loaded in the supporting plastic bag of sterilizing, seal and obtain wet tissue finished product.
Embodiment 2
A kind of wet tissue with promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect, be made up of wet tissue matrix and the base fluid be adsorbed on matrix, described base fluid is made up of the raw material of following quality proportioning: Radix Notoginseng 60 parts, Rhizoma Curculiginis (processed with wine) 35 parts, Radix Dipsaci 30 parts, Folium Et Cacumen Murrayae 25 parts, Herba Reineckeae Carneae 22 parts, 18 parts, five tastes rattan, Lignum Sappan 15 parts, ring stay row 12 parts, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 20 parts, Herba speranskiae tuberculatae 13 parts, Rhizoma Et Radix Notopterygii 8 parts, Cortex Magnoliae Officinalis 10 parts, kadsura root 8 parts, Cortex Periplocae 6 parts.
Dry after first above-mentioned medical material being cleaned, then take each medical material in proportion, respectively by its dozen of powder, cross 40 mesh sieves, then by all medicated powder mixing after sieving; Joined by mixed powder in ultrasonic extraction tank, then add the ethanol that volumetric concentration is 80%-90%, the weight ratio of medicated powder and ethanol is 1:15, through three supersound extraction, (Extracting temperature is room temperature, frequency is 40KW, and each extraction time is 45min), filter, merging filtrate; Be 60%-65% by filtrate decompression Distillation recovery ethanol to the purity of preparation, leave standstill filtering precipitation after 15h subsequently, gained filtrate is base fluid; Wet tissue matrix is immersed in base fluid, after suctioning base fluid, takes out wet tissue matrix, after ultraviolet radiation sterilization, wet tissue is loaded in the supporting plastic bag of sterilizing, seal and obtain wet tissue finished product.
Embodiment 3
A kind of wet tissue with promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect, be made up of wet tissue matrix and the base fluid be adsorbed on matrix, described base fluid is made up of the raw material of following quality proportioning: Radix Notoginseng 65 parts, Rhizoma Curculiginis (processed with wine) 40 parts, Radix Dipsaci 35 parts, Folium Et Cacumen Murrayae 30 parts, Herba Reineckeae Carneae 25 parts, 20 parts, five tastes rattan, Lignum Sappan 20 parts, ring stay row 15 parts, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 25 parts, Herba speranskiae tuberculatae 15 parts, Rhizoma Et Radix Notopterygii 10 parts, Cortex Magnoliae Officinalis 15 parts, kadsura root 10 parts, Cortex Periplocae 10 parts.
Dry after first above-mentioned medical material being cleaned, then take each medical material in proportion, respectively by its dozen of powder, cross 40 mesh sieves, then by all medicated powder mixing after sieving; Joined by mixed powder in ultrasonic extraction tank, then add the ethanol that volumetric concentration is 80%-90%, the weight ratio of medicated powder and ethanol is 1:25, through three supersound extraction, (Extracting temperature is room temperature, frequency is 40KW, and each extraction time is 30min), filter, merging filtrate; Be 60%-65% by filtrate decompression Distillation recovery ethanol to the purity of preparation, leave standstill filtering precipitation after 15h subsequently, gained filtrate is base fluid; Wet tissue matrix is immersed in base fluid, after suctioning base fluid, takes out wet tissue matrix, after ultraviolet radiation sterilization, wet tissue is loaded in the supporting plastic bag of sterilizing, seal and obtain wet tissue finished product.
Product of the present invention is carried out animal safety test:
An intact skin irritant test: erythema and edema phenomenon all do not appear in experimental animal skin, one time intact skin irritant reaction top is " 0 ", belongs to nonirritant.
Skin allergy test: erythema and edema reaction all do not appear in experimental animal skin, and sensitization rate is 0%, by this wet tissue annex solution sensitization intensity of sensitization strength grading standard rating for having no skin allergic reaction.
Toxicity: be LD to chmice acute Oral toxicity
50>5000mg/kgBM, belongs to nontoxic level.
Product of the present invention is carried out the test of human body result of use, choose wherein 8 model cases and its therapeutic effect is described.
Case 1: Lee, man, 17 years old, during motion, left foot was sprained, ankle swelling, hurt like hell, used wet tissue of the present invention ankle detumescence after 2 days, pain disappearance, fully recovered after 7 days.
Case 2: river, female, 42 years old, left side lumbago and skelalgia, can not stand, and used wet tissue of the present invention 3 days pain reliefs, can stand after 12 days.
Case 3: Wu, female, 20 years old, hip fracture, had an intense pain, and used wet tissue of the present invention pain disappearance after 5 days, fully recovered after 20 days.
Case 4: Zhang, man, 54 years old, prolapse of lumbar intervertebral disc, oppressed right lower limb neuralgia treating, used wet tissue of the present invention pain relief after 5 days.
Case 5: Wang, female, 55 years old, scapulohumeral periarthritis, left arm was numb, uses wet tissue of the present invention after 10 days, and feeling of numbness disappears.
Case 6: Lee, man, 46 years old, cervical spondylosis, pain after neck, benumbed during upper limb, uses wet tissue of the present invention pain relief after 5 days, paralysis symptom disappearance after 20 days.
Case 7: Huang, man, 29 years old, enlargement of bilateral parotid glands, had a fever 38.9 degree, use wet tissue of the present invention after 2 days the state of an illness alleviate, fully recover after 5 days.
Case 8: pay certain, female, 9 years old, the enlargement of bilateral mandibular lymph node, had a fever 39.0 degree, use wet tissue of the present invention after 3 days the state of an illness alleviate, fully recover after 7 days.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (4)
1. have the wet tissue of promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect, be made up of wet tissue matrix and the base fluid be adsorbed on matrix, it is characterized in that, described base fluid is made up of the raw material of following quality proportioning:
Radix Notoginseng 50-65 part, Rhizoma Curculiginis (processed with wine) 30-40 part, Radix Dipsaci 30-35 part, Folium Et Cacumen Murrayae 20-30 part, Herba Reineckeae Carneae 20-25 part, five tastes rattan 15-20 part, Lignum Sappan 15-20 part, ring stay row 10-15 part, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 15-25 part, Herba speranskiae tuberculatae 10-15 part, Rhizoma Et Radix Notopterygii 5-10 part, Cortex Magnoliae Officinalis 10-15 part, kadsura root 5-10 part, Cortex Periplocae 5-10 part.
2. a kind of wet tissue with promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect according to claim 1, is characterized in that: the optimization formula of described base fluid is: Radix Notoginseng 60 parts, Rhizoma Curculiginis (processed with wine) 35 parts, Radix Dipsaci 30 parts, Folium Et Cacumen Murrayae 25 parts, Herba Reineckeae Carneae 22 parts, 18 parts, five tastes rattan, Lignum Sappan 15 parts, ring stay row 12 parts, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 20 parts, Herba speranskiae tuberculatae 13 parts, Rhizoma Et Radix Notopterygii 8 parts, Cortex Magnoliae Officinalis 10 parts, kadsura root 8 parts, Cortex Periplocae 6 parts.
3. a kind of wet tissue with promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect according to claim 1, it is characterized in that, preparation method comprises the following steps:
(1) dry after first above-mentioned medical material being cleaned, then take each medical material in proportion, respectively by its dozen of powder, cross 40 mesh sieves, then by all medicated powder mixing after sieving;
(2) mixed powder is joined in ultrasonic extraction tank, then add the ethanol that volumetric concentration is 80%-90%, through three supersound extraction, filtration, merging filtrate;
(3) filtrate decompression Distillation recovery ethanol to purity step (2) prepared is 60%-65%, and after leaving standstill 12-24h subsequently, filtering precipitates, and gained filtrate is base fluid;
(4) wet tissue matrix is immersed in base fluid, after suctioning base fluid, take out wet tissue matrix, after ultraviolet radiation sterilization, wet tissue is loaded in the supporting plastic bag of sterilizing, seal and obtain wet tissue finished product.
4. a kind of preparation method of wet tissue with promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect according to claim 3, it is characterized in that: the weight ratio of described medicated powder and ethanol is 1:15-25, the operating temperature of ultrasonic extraction tank is room temperature, operating frequency is 40KW, and each extraction time is 30-45min.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410577115.7A CN104352726A (en) | 2014-10-24 | 2014-10-24 | Wet tissue with effects of activating blood circulation, dispersing stasis and relieving swellings and pain |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410577115.7A CN104352726A (en) | 2014-10-24 | 2014-10-24 | Wet tissue with effects of activating blood circulation, dispersing stasis and relieving swellings and pain |
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| CN104352726A true CN104352726A (en) | 2015-02-18 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105342913A (en) * | 2015-11-12 | 2016-02-24 | 芜湖悠派护理用品科技股份有限公司 | Wet tissue special for sports and making method thereof |
| CN110327266A (en) * | 2019-08-09 | 2019-10-15 | 肇庆市凯捷科技有限公司 | A kind of amino acid shampoo with bacterio static itching-relieving and hair care repair function |
-
2014
- 2014-10-24 CN CN201410577115.7A patent/CN104352726A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105342913A (en) * | 2015-11-12 | 2016-02-24 | 芜湖悠派护理用品科技股份有限公司 | Wet tissue special for sports and making method thereof |
| CN110327266A (en) * | 2019-08-09 | 2019-10-15 | 肇庆市凯捷科技有限公司 | A kind of amino acid shampoo with bacterio static itching-relieving and hair care repair function |
| CN110327266B (en) * | 2019-08-09 | 2022-05-24 | 肇庆市凯捷科技有限公司 | Amino acid shampoo with functions of inhibiting bacteria, relieving itching and protecting hair and repairing |
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Application publication date: 20150218 |