CN104940816A - Traditional Chinese medicine granule for treating cervical spondylosis and preparation method - Google Patents

Abstract

The invention discloses traditional Chinese medicine granule for treating cervical spondylosis and relates to the technical field of health care products. The traditional Chinese medicine granule is prepared from the following crude drugs by weight: 20-60 g of raw fossil fragments and raw oyster shell, 25-55 g of nacre, 1-9 g of radix curcumae, 20-55 g of root of radix paeoniae rubra, 10-25 g of white paeony root, 5-20 g of raw liquorice, 15-35 g of the root of kudzu vine, 1-5 g of inula flower, 5-20 g of angelica sinensis, 5-20 g of ligusticum wallichii and 3-10 g of frankincense. The traditional Chinese medicine granule has the following benefits: the traditional Chinese medicine granule contains various ingredients for treating cervical spondylosis, has the characteristics of precise pharmacy and high medicine absorbency and effective composition content, is remarkable in curative effect, simple, convenient and feasible in application method, available in raw material, low in price and free of toxic or side effect; cervical spondylosis is unlikely to relapse after being cured and is short in treatment cycle.

Description

A kind of Chinese medicinal granule and preparation method for the treatment of cervical spondylosis

Technical field

The present invention relates to technical field of health care food, be specifically related to a kind of Chinese medicinal granule and preparation method for the treatment of cervical spondylosis.

Background technology

Cervical spondylosis is strained due to long-term chronic, and primary disease increases gradually in China that more to become genuine white-collar occupations sick in recent years.The traditional Chinese medical science there is a lot of research traditional Chinese medical science to think for treatment cervical spondylosis, cervical spondylosis is caused by wind-cold damp pathogen, the evil knot of the stasis of blood, solidifying and do not fall apart, filial piety many treatments cervical spondylosis is for the purpose of expelling wind and cold, activating blood circulation to dissipate blood stasis, follow traditional Chinese medical science general rule not principle bitterly, so effect is thorough, but in real Chinese materia medica, for treatment cervical spondylosis selected by medical material and unreasonable, curative effect is not remarkable yet.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of materials accurately and the oral liquid of the treatment cervical spondylosis that active constituent content is high, absorbability is good and preparation method.

Technical problem to be solved by this invention realizes by the following technical solutions:

Treat a Chinese medicinal granule for cervical spondylosis, it is characterized in that: be made up of the crude drug of following weight portion:

SHENGLONGMU 20-60 gram, Concha Margaritifera 25-55 gram, Radix Curcumae 1-9 gram, Radix Paeoniae Rubra 20-55 gram, Radix Paeoniae Alba 10-25 gram, Radix Glycyrrhizae 5-20 gram, Radix Puerariae 15-35 gram, Flos Inulae 1-5 gram, Radix Angelicae Sinensis 5-20g, Rhizoma Chuanxiong 5-20g, Olibanum 3-10g.

Preferred weight part of each crude drug is:

SHENGLONGMU 30 grams, Concha Margaritifera 30 grams, Radix Curcumae 3 grams, Radix Paeoniae Rubra 30 grams, Radix Paeoniae Alba 15 grams, Radix Glycyrrhizae 10 grams, Radix Puerariae 30 grams, Flos Inulae 3 grams, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 10g, Olibanum 6g.

Another object of the present invention is to provide a kind of method preparing Chinese medicinal granule of the present invention, comprises the following steps:

A, above-mentioned raw materials to be cleaned up, then be wrapped in wherein with a non-woven fabrics, put into after tightening and decoct container, add suitable quantity of water and make submergence medical material, after soaking the matters time, be heated to boil, leach some times, take out gauze and medicine juice is poured in container, again by remaining medicinal residues fried 2-3 time in accordance with the law, collect each fried liquid, after centrifugalize, cryoconcentration is to normal concentration, and the survey (80-90 DEG C) of reheating of the ratio of thick paste is 1.30-1.35;

B, water decoction is evaporated to concentration 1:1, add the ethanol that 1-2 doubly puts after cold, fully mix, placement is spent the night, make it precipitate, get its supernatant next day, a small amount of 50%-60% ethanol of precipitate is cleaned, and washing liquid and filtrate merge, after decompression recycling ethanol, to be concentratedly put cold place to finite concentration time shift and leave standstill 20min, precipitation is filtered completely, and filtrate low-temperature evaporation is to paste;

C, by the paste medical material obtained in above-mentioned b adopt microwave technology carry out the high retention rate that dried can reach effective ingredient;

D, the powdered extract powder obtained in above-mentioned c is added suitable dry adhesives, use and automatically produce facility for granulating pressurization, satisfactory granule can be obtained.

The invention has the beneficial effects as follows: in Chinese medicinal granule of the present invention, all have the various composition for the treatment of cervical spondylosis, have the advantages that medication is accurate, drug absorption is strong, active constituent content is high, evident in efficacy, not easily recur, treatment cycle is short, and using method is simple and easy to do, and raw material is easy to get, cheap, have no side effect.

Detailed description of the invention

The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.

Embodiment 1

Treat a Chinese medicinal granule for cervical spondylosis, be made up of the crude drug of following weight portion:

SHENGLONGMU 20-60 gram, Concha Margaritifera 25-55 gram, Radix Curcumae 1-9 gram, Radix Paeoniae Rubra 20-55 gram, Radix Paeoniae Alba 10-25 gram, Radix Glycyrrhizae 5-20 gram, Radix Puerariae 15-35 gram, Flos Inulae 1-5 gram, Radix Angelicae Sinensis 5-20g, Rhizoma Chuanxiong 5-20g, Olibanum 3-10g.

Its preparation method is as follows:

A, above-mentioned raw materials to be cleaned up, then be wrapped in wherein with a non-woven fabrics, put into after tightening and decoct container, add suitable quantity of water and make submergence medical material, after soaking the matters time, be heated to boil, leach some times, take out gauze and medicine juice is poured in container, again by remaining medicinal residues fried 2-3 time in accordance with the law, collect each fried liquid, after centrifugalize, cryoconcentration is to normal concentration, and it is 1.30-1.35 that the general heat of proportion of thick paste surveys (80-90 DEG C);

B, in order to reduce the dose of granule and draw moist, be evaporated to finite concentration (about 1:1) by water decoction, after cold, add the ethanol that 1-2 doubly puts, abundant mixing, placement is spent the night, and makes it precipitate, and gets its supernatant next day, the a small amount of 50%-60% ethanol of precipitate is cleaned, washing liquid and filtrate merge, and after decompression recycling ethanol, to be concentratedly put cold place to finite concentration time shift and leave standstill certain hour, precipitation is filtered completely, and filtrate low-temperature evaporation is to paste;

C, by the paste medical material obtained in above-mentioned b adopt microwave technology carry out the high retention rate that dried can reach effective ingredient;

D, the powdered extract powder obtained in above-mentioned c is added suitable dry adhesives, use and automatically produce facility for granulating pressurization, satisfactory granule can be obtained.

Embodiment 2

Treat a Chinese medicinal granule for cervical spondylosis, be made up of the crude drug of following weight portion:

Preferred weight part of each crude drug is:

SHENGLONGMU 30 grams, Concha Margaritifera 30 grams, Radix Curcumae 3 grams, Radix Paeoniae Rubra 30 grams, Radix Paeoniae Alba 15 grams, Radix Glycyrrhizae 10 grams, Radix Puerariae 30 grams, Flos Inulae 3 grams, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 10g, Olibanum 6g.

Its preparation method is as follows:

A, above-mentioned raw materials to be cleaned up, then be wrapped in wherein with a non-woven fabrics, put into after tightening and decoct container, add suitable quantity of water and make submergence medical material, after soaking the matters time, be heated to boil, leach some times, take out gauze and medicine juice is poured in container, again by remaining medicinal residues fried 1-2 time in accordance with the law, collect each fried liquid, after centrifugalize, cryoconcentration is to normal concentration, and it is 1.20-1.30 that the general heat of proportion of thick paste surveys (85-90 DEG C);

B, in order to reduce the dose of granule and draw moist, be evaporated to finite concentration (about 1:1) by water decoction, after cold, add the ethanol that 1-2 doubly puts, abundant mixing, placement is spent the night, and makes it precipitate, and gets its supernatant next day, the a small amount of 50%-60% ethanol of precipitate is cleaned, washing liquid and filtrate merge, and after decompression recycling ethanol, to be concentratedly put cold place to finite concentration time shift and leave standstill certain hour, precipitation is filtered completely, and filtrate low-temperature evaporation is to paste;

C, by the paste medical material obtained in above-mentioned b adopt microwave technology carry out the high retention rate that dried can reach effective ingredient;

D, the powdered extract powder obtained in above-mentioned c is added suitable dry adhesives, use and automatically produce facility for granulating pressurization, satisfactory granule can be obtained.

In order to better verify curative effect of the present invention, below by way of the contrast experiment of curative effect group, matched group, further illustrate Chinese medicinal granule beneficial effect provided by the invention.

Grouping and Therapeutic Method

1.1, divide into groups, successively patient is divided into treatment group and matched group at random by consultation time, treatment group 40 example, matched group 40 example;

1.2, treatment group, uses Chinese medicinal granule provided by the invention to treat Patients with Cervical Spondylopathy;

1.3, matched group, commercially available diltiazem slow releasing tablet is treated Patients with Cervical Spondylopathy;

1.4, the course for the treatment of, treatment group and matched group are a course for the treatment of in equal 15 days.

The related data for the treatment of group and matched group.

2.1, course of disease situation is in table one:

Table one

Group	Number of cases	Below February	The 3-5 month	The 6-10 month	More than October
						Treatment group	40	8	12	15	5
Matched group	40	8	12	15	5

3, efficacy assessment standard

3.1, effective, clinical symptom disappearance, recovers normally to work;

3.2, take a turn for the better, clinical symptom remission, work slightly receives impact, occasionally has recurrence.

3.3, invalid, after treating 3 courses for the treatment of, symptom has no alleviation.

4, experimental result (after 3 courses for the treatment of) is in table two

Table two

Group	Number of cases	Effective	Take a turn for the better	Invalid	Total effective rate
						Treatment group	40	32	6	2	95.0％
Matched group	40	20	12	8	80.0％

As can be seen from above experiment, Chinese medicinal granule provided by the invention has more significant curative effect to cerebral arteriosclerosis.

More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.

Claims (3)

1. treat a Chinese medicinal granule for cervical spondylosis, it is characterized in that: be made up of the crude drug of following weight portion:

SHENGLONGMU 20-60 gram, Concha Margaritifera 25-55 gram, Radix Curcumae 1-9 gram, Radix Paeoniae Rubra 20-55 gram, Radix Paeoniae Alba 10-25 gram, Radix Glycyrrhizae 5-20 gram, Radix Puerariae 15-35 gram, Flos Inulae 1-5 gram, Radix Angelicae Sinensis 5-20g, Rhizoma Chuanxiong 5-20g, Olibanum 3-10g.

2. a kind of Chinese medicinal granule for the treatment of cervical spondylosis according to claim 1, is characterized in that: the preferred weight of each raw material is:

SHENGLONGMU 30 grams, Concha Margaritifera 30 grams, Radix Curcumae 3 grams, Radix Paeoniae Rubra 30 grams, Radix Paeoniae Alba 15 grams, Radix Glycyrrhizae 10 grams, Radix Puerariae 30 grams, Flos Inulae 3 grams, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 10g, Olibanum 6g.

3. prepare the method with the Chinese medicinal granule for the treatment of cervical spondylosis of claim 1-2 described in any one, it is characterized in that: comprise the following steps:

A, above-mentioned raw materials to be cleaned up, then be wrapped in wherein with a non-woven fabrics, put into after tightening and decoct container, add suitable quantity of water and make submergence medical material, after soaking the matters time, be heated to boil, leach some times, take out gauze and medicine juice is poured in container, again by remaining medicinal residues fried 2-3 time in accordance with the law, collect each fried liquid, after centrifugalize, cryoconcentration is to normal concentration, and the survey (80-90 DEG C) of reheating of the ratio of thick paste is 1.30-1.35;

B, water decoction is evaporated to concentration 1:1, add the ethanol that 1-2 doubly puts after cold, fully mix, placement is spent the night, make it precipitate, get its supernatant next day, a small amount of 50%-60% ethanol of precipitate is cleaned, and washing liquid and filtrate merge, after decompression recycling ethanol, to be concentratedly put cold place to finite concentration time shift and leave standstill 20min, precipitation is filtered completely, and filtrate low-temperature evaporation is to paste;

C, by the paste medical material obtained in above-mentioned b adopt microwave technology carry out the high retention rate that dried can reach effective ingredient;

The powdered extract powder obtained in above-mentioned c is added suitable dry adhesives, uses and automatically produce facility for granulating pressurization, satisfactory granule can be obtained.