CN104784243B - A kind of application of Chinese medicine composition that can effectively treat frostbite rhagadia in prevention, treatment diabetes - Google Patents
A kind of application of Chinese medicine composition that can effectively treat frostbite rhagadia in prevention, treatment diabetes Download PDFInfo
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- CN104784243B CN104784243B CN201510126472.6A CN201510126472A CN104784243B CN 104784243 B CN104784243 B CN 104784243B CN 201510126472 A CN201510126472 A CN 201510126472A CN 104784243 B CN104784243 B CN 104784243B
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Abstract
The present invention relates to a kind of application of Chinese medicine composition that can effectively treat frostbite rhagadia in prevention, treatment diabetes, the Chinese medicine composition contains Ganodenna Lucidum P.E and semen vaccariae extraction and pharmaceutically acceptable auxiliaries, and the weight ratio of Ganodenna Lucidum P.E and semen vaccariae extraction is calculated as 0.01 with crude drug:9.99~9.99:0.01.By the present invention in that it can effectively treat pharmacodynamics, the clinical experimental study that the Chinese medicine composition of frostbite rhagadia carries out diabetes with above-mentioned, the results showed that, there are extraordinary prevention and treatment diabetes, it is safe to use, curative for effect.
Description
Technical field
The invention belongs to Chinese medicine preparation new application technical fields, and in particular to a kind of Chinese medicine that can effectively treat frostbite rhagadia
Application of the composition in prevention, treatment diabetes.
Background technology
Diabetes be one group caused by defect of insulin secretion and/or insulin action obstacle characterized by hyperglycemia
Metabolic disease.Persistent high blood sugar and long-term metabolic disorder etc. can lead to body tissue's organ, particularly eye, kidney, angiocarpy
And the damage of nervous system and its dysfunction and failure；Severe patient, which can cause, loses water and rock-soil coupling and acid-base imbalance
Wait acute complications ketoacidosis and Hyperosmotic coma.Statistics has 34,700,000 diabetics in the world within 2013.In 2004,
About 3,400,000 people die of hyperglycemia, estimate same amount of death toll, low income and middle income country within 2010
Distribution of diabetes be more than 80%.Low income and the distribution of diabetes of middle income country are more than 80%.In developed country
In, the age of most of diabetic is concentrated mainly on 35-64 at the age all more than the retirement age, in developing country
Year.
Diabetes are a kind of serious complication occurred during diabetes illness, refer to diabetic foot by
Lower limb defencive function is made to decline in neuropathy, big blood vessel and microangiopathies make arterial perfusion deficiency cause microcirculation disorder and send out
The morbid state of raw ulcer and gangrene.Diabetes harm is serious, be diabetic disable in addition lethal major reason it
One, it not only causes suffering to patient, and it is made to add huge financial burden.
It is shown according to the graduate research report of diabetes, foot occurs in the course of disease for 15%-20% in diabetic
Ulcer is divided into neural pedopathy, ischemic pedopathy and Combination pedopathy according to the main reason for causing ulcer.Clinical report shows,
In diabetic foot ulcer, ulcer spot is most commonly seen with the first toes, accounts for about 47%.Neurogenic ulcer is more typical, accounts for about 64%,
Ischemic diabetic foot accounts for about 36%.In recent years, related diabetes some statistics indicate that：1. in every 6 diabetics
There to be 1 ulcer of foot can occur in life at it.2. there are 4,000,000 diabetics that ulcer of foot occurs every year.3. the whole world every 30
Just there is 1 people's amputation due to diabetes in second.4. foot complication is the most common reason of being hospitalized of diabetic.5. developing
Middle country's foot affliction accounts for the 40% of health care resources.6. because the direct cost estimation of diabetes amputation is in 30,000-6 ten thousand U.S.s
Member.
Have currently on the market for the effective method of diabetes：1. insulin can improve metabolism, promote albumen synthesis,
Conducive to the control of reparation and the infection of ulcer.Suitable depressor and fat regulation medicine are selected simultaneously, blood pressure and blood fat control are arrived
Advantageous rehabilitation environment is created in ideal range, the treatment for diabetes drafting foot.2. common depressor turns for angiotensins
Change enzyme inhibitor；3. fat regulation medicine has to reduce Statins based on cholesterol and to reduce the fibrates based on triglyceride.Portion
Divide patient's suffering limb oedema more apparent, influence local nutrition, make ulcer healing slow, it should be noted that lifting affected limb improves vein and returns
Stream；Diuretics significantly can be used in oedema.4. ulcer treatment drug.For the ulcer of the surface of a wound, Iodophor pair is used under normal circumstances
It carries out disinfection, its slough is cleared up, and the drugs such as the treatment Yi Banshiyongyushi sugar subcutaneous ulcer health of the surface of a wound are controlled
It treats, it is main to focus on going its detoxification rotten, quick repair.For existing treatment means mainly based on chemical drug, effect is undesirable,
And more serious adverse reaction can be brought while treatment；It has been reported that the patient festered with diabetes is nearly
Half need to be used and be treated the methods of amputation.
The crude drug of Chinese medicine preparation of the present invention forms：The seed of cowherb, ganoderma lucidum.Major function is：By direct
It is applied to affected part and achievees the purpose that myogenic sore, prevention and treatment frostbite.It is related to the composition, preparation side of this Chinese medicine composition
The contents such as method, dosage form and method of quality control are in Chinese invention patent " a kind of ointment for treating frostbite rhagadia and its preparation side
The method " (patent No.：ZL 201010220343.0, publication date be on January 11st, 2012) in have more detailed description.
Invention content
For the needs of reality, the object of the present invention is to provide the above-mentioned Chinese medicine compositions that can effectively treat frostbite rhagadia to exist
Application in prevention, treatment diabetes, it is safe to use, it is curative for effect.
To achieve the above objectives, the technical solution adopted by the present invention is：A kind of Chinese medicine group that can effectively treat frostbite rhagadia
Application of the object in prevention, treatment diabetes is closed, the Chinese medicine composition contains Ganodenna Lucidum P.E and semen vaccariae extraction
And pharmaceutically acceptable auxiliaries, the weight ratio of Ganodenna Lucidum P.E and semen vaccariae extraction are calculated as 0.01 with crude drug:9.99~9.99:
0.01.Its pharmaceutic adjuvant used is glycerin monostearate, stearic acid, vaseline, atoleine, lanolin and three ethyl alcohol
Amine, sodium chloride, ethylparaben etc..
Further, the diabetes refer to diabetic foot since neuropathy makes lower limb defencive function decline,
Big blood vessel and microangiopathies make arterial perfusion deficiency cause microcirculation disorder and ulcer and gangrenous morbid state occurs, and are glycosurias
A kind of complication of disease.The symptom of the diabetes is selected from the group：Diabetic foot ulcer or gangrene, diabetic peripheral neuropathy
Change, diabetes microcirculation disorder and combinations thereof.
Further, the weight ratio of Ganodenna Lucidum P.E and semen vaccariae extraction is calculated as 1 with crude drug:4~4:1.
Further, the weight ratio of Ganodenna Lucidum P.E and semen vaccariae extraction is calculated as 1 with crude drug:2~2:1.
Further, the Chinese medicine composition is paste.
By the present invention in that the drug effect that diabetes are carried out with the above-mentioned Chinese medicine composition that can effectively treat frostbite rhagadia
It learns, clinical experimental study, the results showed that, there is extraordinary prevention and treatment diabetes, safe to use, curative effect
Definitely.
Specific embodiment
The invention will be further described With reference to embodiment.
Pharmacological experiment
Test example 1
(weight ratio of Ganodenna Lucidum P.E and semen vaccariae extraction is with life for illustrating compound ganoderma frostbite cream for this test example
Medicine is calculated as 1:2, preparation method is shown in granted patent (ZL 201010220343.0)) to part frozen rat whole blood viscosity, blood coagulation
The influence situation of factor I, hematocrit and Plasma Viscosity.
Rat 24, be randomly divided into normal group, model group, administration group, 3 groups each 6.First laboratory adapt to 1 week, then
With the intraperitoneal injection of 1% yellow Jackets in anesthesia shape.The double metapedes ankle-joints of rat in addition to normal group are immersed with lower portion-
5min in 25 DEG C of ethyl alcohol, causes diabetes model.After moulding 6h start grouping administration, model group except daily replace gauze in addition to,
No any other processing, administration group embrocate compound ganoderma frostbite cream in affected part, 3 times a day, break end after successive administration 48h, 52h and take
Blood examination is tested：Whole blood viscosity (uses NEX.1 type cone-plate formula blood viscosities meter)；Hematocrit and Plasma Viscosity (using 1.5 ×
The capillary viscosmeter of 75mm).
Each group frostbite rat whole blood viscosity, plasma viscosity, hematocrit testing result (N=6, xIt is average± s) it is shown in Table 1.
Table 1
Note：Compared with normal group,*1P<0.01；Compared with model group,*2P<0.01,*3P<0.05
As it can be seen from table 13 whole blood viscosity of model group, hematocrit and Plasma Viscosity levels are all remarkably higher than
Normal group, and the indices of administration group are significantly lower than model group, and compound ganoderma frostbite cream test group result is frozen compared with ganoderma lucidum
It is excellent to hinder cream group.
Test example 2
This test example is used to illustrate stimulation of the compound ganoderma emulsifiable paste (with test example 1) to skin.
Method：New zealand rabbit 10, weight 2.5kg or so, half male and half female take off hair outer at left and right sides of buttocks with depilatory agent
It goes, matrix (3 centimetres or so of diameter) is applied at the hairless position in left side, the hairless place in right side applies compound ganoderma emulsifiable paste (diameter is identical), often
Day twice, continuous 20 days.
As a result：Coating is showed no the stimulate the reactions such as redness with matrix position, all grows virgin wool.
Application examples 1
The application example is used to illustrate compound ganoderma emulsifiable paste (with test example 1) in 60 patient with diabetic feet clinical treatment feelings
Condition.
1. test medicine：Compound ganoderma emulsifiable paste, is produced by Beijing XieHe medicine Factory；
2. tested crowd：This group man 25, female 35, age 41-65 Sui (54 years old average).Equal more than the 5a of diabetic history；6
Example complication with diabetes nephrosis, 14 complication with diabetes retinopathy, 41 insulin therapies, 19 oral hypoglycemic agents, on an empty stomach
Blood glucose 6.5-10.5mmol/L.This group of patient is not in the mood for, Liver and kidney function damage.
3. medication：Patient's foot disease surface smear compound ganoderma emulsifiable paste, 3 times a day.
4. severity Scaling and efficacy determination
It is divided into 4 grades by state of an illness weight：0 grade, normal foot；I grades, skin belongs to high-risk foot without explorative ulcer；II grade, have
Explorative lesion, bubble, corn, scald or frostbite and other damages cause exulceratio simplex, and lesion does not involve deep tissue；Ⅲ
Grade, infection is invaded and deep tissue, often has cellulitis, multiple purulence ulcer and sinus infection to expand, and forms vola, toes perforation
Property ulcer, dense sexual secretion is more, but tendon, ligament there is no destruction.
Determination method：It is effective：The state of an illness improves 2 grades or more；Effectively：The state of an illness improves 1 grade；In vain：The state of an illness is without improvement.
5. effective 33 of result, accounts for 55%；Effective 15, account for 25%；Invalid 12, account for 20%.Total effective rate 80%.
Above-described embodiment is for example, the present invention can also be with other ad hoc fashions or others to the present invention
Particular form is implemented, without departing from the gist of the invention or substantive characteristics.Therefore, from the point of view of the embodiment of description is in terms of any
It is regarded as illustrative and non-limiting.The scope of the present invention should illustrate by appended claims, any and claim
Intention and the equivalent variation of range should also be included in the scope of the present invention.
Claims (3)
1. a kind of Chinese medicine composition that can effectively treat frostbite rhagadia answering in the drug for preparing prevention, treatment diabetes
With, the Chinese medicine composition is made of Ganodenna Lucidum P.E and semen vaccariae extraction and pharmaceutically acceptable auxiliaries, Ganodenna Lucidum P.E and
The weight ratio of semen vaccariae extraction is calculated as 1 with crude drug:2.
2. application according to claim 1, which is characterized in that the diabetes refer to diabetic foot due to god
Lower limb defencive function is made to decline through lesion, big blood vessel and microangiopathies make arterial perfusion deficiency cause microcirculation disorder and burst
The morbid state of ulcer and gangrene is a kind of complication of diabetes.
3. application according to claim 1 or 2, which is characterized in that the Chinese medicine composition is paste.
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| CN101057942A (en) * | 2006-06-19 | 2007-10-24 | 张振春 | External applied medicine ointment for treating diabetes foot and its preparing method |
| CN101849982A (en) * | 2009-04-02 | 2010-10-06 | 北京协和药厂 | Ointment for treating frostbite rhagadia |
| CN102091264A (en) * | 2010-11-25 | 2011-06-15 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating diabetic foot |
| CN102309536A (en) * | 2010-07-06 | 2012-01-11 | 北京协和药厂 | Ointment for treating frostbite and rahagades and preparation method of ointment |
| CN103479828A (en) * | 2012-06-15 | 2014-01-01 | 史昌灵 | Formula of incised wound ointment, and preparation method of incised wound ointment |
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2015
- 2015-03-23 CN CN201510126472.6A patent/CN104784243B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101057942A (en) * | 2006-06-19 | 2007-10-24 | 张振春 | External applied medicine ointment for treating diabetes foot and its preparing method |
| CN101849982A (en) * | 2009-04-02 | 2010-10-06 | 北京协和药厂 | Ointment for treating frostbite rhagadia |
| CN102309536A (en) * | 2010-07-06 | 2012-01-11 | 北京协和药厂 | Ointment for treating frostbite and rahagades and preparation method of ointment |
| CN102091264A (en) * | 2010-11-25 | 2011-06-15 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating diabetic foot |
| CN103479828A (en) * | 2012-06-15 | 2014-01-01 | 史昌灵 | Formula of incised wound ointment, and preparation method of incised wound ointment |
Non-Patent Citations (1)
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| 加用李桂文名老中医外洗方治疗糖尿病足24例;王永辉 等;《广西中医药》;20090630;第32卷(第3期);48-49 * |
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Address after: 102600 building 7, 37 Yongwang Road, Daxing biomedical industrial base, Zhongguancun Science and Technology Park, Daxing District, Beijing Patentee after: Beijing Xiehe Pharmaceutical Co.,Ltd. Address before: 102600 building 7, 37 Yongwang Road, Daxing biomedical industrial base, Zhongguancun Science and Technology Park, Daxing District, Beijing Patentee before: Beijing Union Pharmaceutical Factory |