CN114788838A - Pain-relieving gel and preparation method thereof - Google Patents

Abstract

The invention discloses an analgesic gel, which comprises the following raw materials of a main drug and an adjuvant drug, wherein the main drug comprises the following components: notoginseng radix, radix Angelicae Pubescentis, radix Saposhnikoviae, rhizoma Drynariae, Mentholum, and Camphora; the adjuvant comprises: the main drug comprises carboxyvinyl polymer, p-hydroxybenzoate ester, propyl p-hydroxybenzoate ester, propylene glycol, double distilled liquor and triethanolamine, wherein the main drug is prepared from the following raw materials in parts by weight: 5-7 parts of pseudo-ginseng, 5-7 parts of radix angelicae pubescentis, 5-7 parts of divaricate saposhnikovia root, 5-7 parts of rhizoma drynariae, 5-7 parts of menthol and 2-4 parts of camphor; the adjuvant is prepared from the following raw materials in percentage by weight: 0.7 percent of carboxyvinyl polymer, 0.2 percent of p-hydroxybenzoate, 0.47 percent of triethanolamine, 0.1 percent of propyl p-hydroxybenzoate, 1.2 percent of propylene glycol, 50 percent of double distilled liquor and 30.80 to 36.37 percent of water. The invention has the functions of removing arthralgia, relieving pain, removing blood stasis, reducing swelling, tonifying bones and promoting tissue regeneration, can relieve joint swelling and pain caused by gout and is more effective on bruise swelling and pain. The gel-shaped liquid has strong viscosity, is not easy to lose, has prolonged drug effect, and has the characteristics of convenient carrying and use.

Description

Pain-relieving gel and preparation method thereof

Technical Field

The invention belongs to the field of traditional Chinese medicines, and particularly relates to an analgesic gel and a preparation method thereof.

Background

The traumatic injury, the rheumatism and the rheumatoid bone pain bring great pain to daily work and life of patients, and even cause disability or even threaten life if the middle-aged and the elderly and other patients with weak constitution are not treated in time, thereby bringing great mental pain and life pressure to the patients and families. At present, the traditional Chinese medicine preparation for treating traumatic injury and rheumatic ostealgia is prepared from liquid of water, oil and alcohol, has high volatility, is stimulated in taste, is easy to run off, has short drug effect, and has quick drying time and poor permeability. At present, the swelling-diminishing and pain-relieving gel which can be used in clinical and daily life and has good effect and small side effect is urgently needed to be found, and the gel is an effective means for relieving the pain of patients suffering from rheumatism and osteodynia caused by traumatic injury.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides the pain-relieving gel and the preparation method thereof. The pain-relieving gel has the effects of removing arthralgia, relieving pain, removing blood stasis, relieving swelling, tonifying bones and promoting granulation, can relieve joint swelling and pain caused by gout, and is more effective on bruise swelling and pain. The gel can quickly permeate into the skin to directly reach the affected part by massage during smearing, the blood circulation effect is better, the medicine stays in the affected part for a longer time, the drying time is prolonged, the permeability is increased, volatilization is slowed down, the smell is mild, the medicine effect is prolonged, the gel-shaped liquid is strong in viscosity and not easy to run off, and the problems in the background technology can be effectively solved. In order to solve the technical problems, the technical scheme adopted by the invention is as follows: an analgesic gel, the raw materials include principal drugs and adjuvant drugs, the principal drugs include: notoginseng radix, radix Angelicae Pubescentis, radix Saposhnikoviae, rhizoma Drynariae, Mentholum, and Camphora; the adjuvant comprises: carboxyvinyl polymer, p-hydroxybenzoate ester, propyl p-hydroxybenzoate ester, propylene glycol, double distilled liquor, and triethanolamine.

The main medicine is prepared from the following raw materials in parts by weight: 5-7 parts of pseudo-ginseng, 5-7 parts of radix angelicae pubescentis, 5-7 parts of divaricate saposhnikovia root, 5-7 parts of rhizoma drynariae, 5-7 parts of menthol and 2-4 parts of camphor.

The adjuvant is prepared from the following raw materials in percentage by weight: 0.7 percent of carboxyvinyl polymer, 0.2 percent of p-hydroxybenzoate, 0.47 percent of triethanolamine, 0.1 percent of propyl p-hydroxybenzoate, 1.2 percent of propylene glycol, 50 percent of double distilled liquor and 30.80 to 36.37 percent of water.

The medicine properties of the raw material medicines are as follows: notoginseng radix has effects of promoting blood circulation, relieving pain, stopping bleeding, and removing blood stasis; radix Angelicae Pubescentis has effects of dispelling pathogenic wind, removing dampness, dispelling cold and relieving pain; radix Saposhnikoviae has effects of relieving exterior syndrome, dispelling pathogenic wind, and removing dampness; rhizoma Drynariae has effects of promoting blood circulation, relaxing muscles and tendons, invigorating kidney, and strengthening bone; the menthol has the effects of relieving itching, alleviating pain, preventing corrosion, stimulation, anesthesia, cooling and resisting inflammation; the camphor has the effects of dredging orifices, benefiting qi stagnation, removing dirt, killing parasites, relieving itching, reducing swelling and relieving pain, and the carboxyl ethylene polymer has the effects of protecting skin, resisting ultraviolet rays, diminishing inflammation and sterilizing; the paraben has bactericidal and fungicidal effects; propyl p-hydroxybenzoate has antiseptic, antioxidant and antibacterial effects; the efficacy of triethanolamine adjusts pH and emulsifies immiscible fluids. The propylene glycol has the effects of hydrophilicity and moisture retention; the double distilled liquor has effects of relaxing muscles and tendons and activating collaterals.

A preparation method of the pain-relieving gel comprises the following steps: the method is characterized by comprising the following steps: the first step is as follows: dissolving p-hydroxybenzoate, propyl p-hydroxybenzoate and menthol in propylene glycol to obtain solution A.

The second step is that: adding menthol and camphor into the solution A, and stirring to dissolve to obtain a solution B.

The third step: mixing Notoginseng radix, radix Angelicae Pubescentis, radix Saposhnikoviae, rhizoma Drynariae and double distilled liquor, stirring and dissolving to obtain mixture X.

The fourth step: the carboxyvinyl polymer was mixed with an appropriate amount of water and stirred, and solution B was added and stirred for 5 minutes to give mixture Y.

The fifth step: the mixture Y was added to the mixture X, and stirred for 10 minutes to obtain a mixture Z.

And a sixth step: adding triethanolamine and water into the mixture Z to obtain a mixture W, and emulsifying the mixture W in vacuum at high speed for 5 minutes to obtain the finished product.

The invention has the beneficial effects that: has effects in relieving arthralgia, relieving pain, removing blood stasis, relieving swelling, tonifying bone, promoting granulation, and relieving joint swelling and pain caused by gout, and is more effective on bruise type swelling and pain. The gel-shaped liquid can quickly permeate into the skin to directly reach the affected part by massage during smearing, has better blood running effect, longer time for the drug to stay in the affected part, prolonged drying time, increased permeability, slow volatilization, mild smell, prolonged drug effect, strong viscosity and difficult loss, has the characteristics of convenient carrying and use, and does not influence the normal work and life of a patient.

The using method comprises the following steps: it is used externally. The affected part skin is cleaned and wiped dry, and the jelly is applied to the affected part 3 to 5 times a day, and 10 days is a treatment course. The mild patients can be cured in 5 days, and the severe patients can be cured in 4 to 6 treatment courses.

The technical solution of the present invention is further described in detail with reference to the following examples.

Detailed Description

Example 1

Weighing main raw material medicines: 5 parts of pseudo-ginseng, 5 parts of radix angelicae pubescentis, 5 parts of divaricate saposhnikovia root, 5 parts of rhizoma drynariae, 5 parts of menthol and 2 parts of camphor for later use.

Weighing the following auxiliary medicines in percentage by weight: 0.7% of carboxyvinyl polymer, 0.2% of p-hydroxybenzoate, 0.47% of triethanolamine, 0.1% of propyl p-hydroxybenzoate, 1.2% of propylene glycol, 50% of double distilled liquor and 36.37% of water for later use.

A preparation method of the pain-relieving gel comprises the following steps: the method comprises the following steps: the first step is as follows: 0.2 percent of p-hydroxybenzoate, 0.1 percent of propyl p-hydroxybenzoate and 5 percent of menthol are dissolved in 1.2 percent of propylene glycol according to weight percentage to obtain a solution A.

The second step is that: adding 5 parts of menthol and 2 parts of camphor into the solution A according to the weight percentage, and stirring and dissolving to obtain a solution B.

The third step: mixing 5 parts of pseudo-ginseng, 5 parts of radix angelicae pubescentis, 5 parts of radix sileris and 5 parts of rhizoma drynariae with 50% double distilled liquor according to parts by weight, and stirring and dissolving to obtain a mixture X.

The fourth step: 0.7% carboxyvinyl polymer by weight was mixed with an appropriate amount of water and stirred, solution B was added and stirred for 5 minutes to obtain mixture Y.

The fifth step: the mixture Y was added to the mixture X, and stirred for 10 minutes to obtain a mixture Z.

And a sixth step: adding 0.47% of triethanolamine and the rest of water into the mixture Z according to the weight percentage to obtain a mixture W, and emulsifying the mixture W for 5 minutes in vacuum and at high speed to obtain the pain-relieving gel.

Example 2

Weighing the following main raw materials in parts by weight: 7 parts of pseudo-ginseng, 7 parts of radix angelicae pubescentis, 7 parts of radix saposhnikoviae, 7 parts of rhizoma drynariae, 7 parts of menthol and 4 parts of camphor for later use.

Weighing the following auxiliary medicines in percentage by weight: 0.7% of carboxyvinyl polymer, 0.2% of p-hydroxybenzoate, 0.47% of triethanolamine, 0.1% of propyl p-hydroxybenzoate, 1.2% of propylene glycol, 50% of double distilled liquor and 30.80% of water for later use.

The preparation method of the pain-relieving gel comprises the following steps: the first step is as follows: 0.2 percent of p-hydroxybenzoate, 0.1 percent of propyl p-hydroxybenzoate and 7 percent of menthol are dissolved in 1.2 percent of propylene glycol according to weight percentage to obtain a solution A.

The second step: adding 7 parts of menthol and 4 parts of camphor into the solution A according to the weight percentage, and stirring and dissolving to obtain a solution B.

The third step: mixing 7 parts of pseudo-ginseng, 7 parts of radix angelicae pubescentis, 7 parts of radix sileris and 7 parts of rhizoma drynariae with 50% double distilled liquor according to parts by weight, and stirring and dissolving to obtain a mixture X.

The fourth step: 0.7% by weight of carboxyvinyl polymer was mixed with an appropriate amount of water and stirred, and solution B was added and stirred for 5 minutes to obtain mixture Y.

The fifth step: the mixture Y was added to the mixture X, and stirred for 10 minutes to obtain a mixture Z.

And a sixth step: adding 0.47% of triethanolamine and the rest of water into the mixture Z according to the weight percentage to obtain a mixture W, and emulsifying the mixture W for 5 minutes in vacuum and at high speed to obtain the pain-relieving gel.

Description of typical cases:

case 1: for a male with age of 26 years old and with obvious swelling and extremely painful arm parts during rowing training, the pain relieving gel of the invention is immediately used, the pain is obviously relieved after the gel is smeared on the arm parts for 5 minutes, and the training can be continued.

Case 2: after the gel is applied for 4 to 5 times every day, the pain is relieved in the same day, the gel is gradually restored to be normal after one month, and the gel can be normally walked after two months.

Case 3: plum, a woman in 35 years old, is hard to bear because of bruising, leg swelling and pain, the pain relieving gel of the invention is immediately used and is smeared for 3-4 times every day, the pain is relieved after 2 minutes, and the swelling disappears after 3 days.

Case 4: zhu Zhi, male, 35 years old, cannot walk because of heel hyperosteogeny and heel pain. The pain-relieving gel is immediately used and is smeared for 3 to 5 times a day, the pain is relieved after 2 minutes, and the gel is healed for more than one month.

In case 5, Zhangzhi, female, age 40, assembly line workers can not work after long-term assembly line formation for arthritis, joint bending, swelling and pain, after the pain relieving gel disclosed by the invention is used, the joint pain is obviously relieved, and the disease can be cured after 2 treatment courses.

Case 6, a male with a side certain, age 60, suffered from rheumatic pain in the knees, had swollen and was unable to take care of himself when sitting or rising. After the pain-relieving gel is used, the arthralgia is obviously relieved, and the gel is cured in 2 half treatment courses.

In case 7, Ma Zhi, male, 50 years old, lumbago was mainly aching pain and distending pain, the pain was obvious during the stooping action, and the pain was relieved after mild activities. The lumbago can be nearly cured after 3 treatment courses of the pain-relieving gel.

In case 8, Raney, male and 62 years old, gout occasionally occurs due to high uric acid in the body, and redness and swelling and heat pain appear in the large toe area as the main symptoms. When gout attacks, the pain relieving gel is smeared on an affected part, and the swelling and pain can be completely eliminated within 5 minutes.

Claims (2)

1. The pain-relieving gel comprises main drugs and auxiliary drugs, and is characterized in that the main drugs comprise: notoginseng radix, radix Angelicae Pubescentis, radix Saposhnikoviae, rhizoma Drynariae, Mentholum, and Camphora; the adjuvant comprises: carboxyvinyl polymer, p-hydroxybenzoate, propyl p-hydroxybenzoate, propylene glycol, double distilled liquor, and triethanolamine; the main medicine is prepared from the following raw materials in parts by weight: 5-7 parts of pseudo-ginseng, 5-7 parts of radix angelicae pubescentis, 5-7 parts of divaricate saposhnikovia root, 5-7 parts of rhizoma drynariae, 5-7 parts of menthol and 2-4 parts of camphor; the adjuvant is prepared from the following raw materials in percentage by weight: 0.7 percent of carboxyvinyl polymer, 0.2 percent of p-hydroxybenzoate, 0.47 percent of triethanolamine, 0.1 percent of propyl p-hydroxybenzoate, 1.2 percent of propylene glycol, 50 percent of double distilled liquor and 30.80 to 36.37 percent of water.

2. The method of making an analgesic gel according to claim 1, wherein the method comprises: the first step is as follows: dissolving p-hydroxybenzoate, propyl p-hydroxybenzoate and menthol in propylene glycol to obtain solution A;

the second step is that: adding menthol and camphor into the solution A, and stirring and dissolving to obtain a solution B;

the third step: mixing Notoginseng radix, radix Angelicae Pubescentis, radix Saposhnikoviae, rhizoma Drynariae and double distilled liquor, stirring and dissolving to obtain mixture X;

the fourth step: mixing the carboxyvinyl polymer with a proper amount of water, stirring, adding the solution B, and stirring for 5 minutes to obtain a mixture Y;

the fifth step: adding the mixture Y into the mixture X, and stirring for 10 minutes to obtain a mixture Z;

and a sixth step: adding triethanolamine and water into the mixture Z to obtain a mixture W, and emulsifying the mixture W in vacuum at high speed for 5 minutes to obtain the finished product.