CN104587279B - Oil-in-water type menthol ointment and preparation method thereof - Google Patents
Oil-in-water type menthol ointment and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of oil-in-water type menthol ointment and preparation method thereof.The oil-in-water type menthol ointment contains the components such as glycerine, camphor, menthol, blue gum leaf oil, licorice, vitamin E, allantoin, citronella oil, there is refrigerant, anti-inflammatory, antipruritic, mosquito repellent, and have the advantages that stability is high, irritation is low, greasy feeling is small.
Description
Technical field
The present invention relates to a kind of menthol ointment and preparation method thereof, more particularly to a kind of oil-in-water type menthol ointment and its preparation
Method.
Background technology
Traditional menthol ointment is using camphor, menthol as main component, and added with the drug ingedient such as gaultherolin
Ointment type preparation, it mainly serves refrigerant, antipruritic.
Traditional menthol ointment uses ointment type matrix, and greasy feeling is heavier when it is used, and excessive oil content is smeared on skin
Sticky uncomfortable skin sense can be produced, is not easy to daily use.In addition, change of the menthol ointment of ointment type matrix to environment temperature
It is more sensitive, easily occur condensate oil phenomenon when summer temp is higher, seriously affect use and effect of menthol ointment；It is moreover, oily
It is difficult to water soluble ingredient of the addition with skin care opsonic action in cream type matrix, it is difficult to the effect of producing more preferably.Therefore, Ren Menxi
Oil-in-water type menthol ointment is developed in prestige, the defects of to solve present in traditional ointment type menthol ointment.
However, due to containing the volatile ingredients such as camphor, menthol in peppermint paste formulation, oil-in-water type menthol ointment is prepared into
When, the problems such as easily producing lotion discoloration, thinning, condensate oil.Camphor, menthol belong to terpene substances, volatile, in oil-in-water type
In emulsifiable paste system, easily assemble because of the rise of environment temperature (such as in temperature higher summer), oil droplet is gradually increased
Greatly, the stability of emulsification system is finally destroyed, makes that lotion is thinning, condensate oil；Meanwhile the aggregation of volatile oil, make easily to aoxidize into
Effective protection of antioxidant can not be obtained by dividing, it is easier to which there is a phenomenon where oxidation stain.Due to using traditional emulsifying agent and breast
Chemical industry skill is difficult to the stability problem for solving oil-in-water type emulsifiable paste system, therefore limits the exploitation of oil-in-water type menthol ointment.
Furthermore contain substantial amounts of camphor, menthol and gaultherolin, the wherein content of camphor about in traditional menthol ointment
For 8~15%, the content of menthol is about 1~5%, and the content of gaultherolin is about 0.3~0.5%, its thorn to skin
It is larger to swash property, and there is sensitization, is not suitable for long-term use, is especially not suitable for infant's use.Therefore, people also wish to develop
Go out low, gentle, the effective menthol ointment of irritation.
The content of the invention
Based on this, it is an object of the present invention to provide a kind of oil-in-water type menthol ointment, its with refrigerant, anti-inflammatory, it is antipruritic,
The effect of mosquito repellent, and have the advantages that stability is high, irritation is low, greasy feeling is small.
It is a further object of the invention to provide the preparation method of the oil-in-water type menthol ointment.
A kind of oil-in-water type menthol ointment, by weight percentage including following components：
And the purified water of its surplus.
In one of the embodiments, the acrylate copolymer/isoparaffin/laureth is selected from polyacrylic acid
Ammonium/C13-16 isoparaffins/laureth -25 or acrylate copolymer/mineral oil/laureth -23.
In one of the embodiments, in the acrylate copolymer/isoparaffin/laureth, acrylic acid gathers
Compound, isoparaffin, the mass ratio of laureth are (5~6) ︰ (3~4) ︰ (4~5).
In one of the embodiments, the laureth is selected from laureth -20, laureth -23, the moon
Combination more than one or both of laureth -25.
In one of the embodiments, the oleaginous base contains grape-kernel oil, beeswax, cetostearyl alcohol, the octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester, dimethyl silicone polymer and stearine.
In one of the embodiments, calculated according to the percentage by weight of the oil-in-water type menthol ointment, the oiliness
Matrix contains：
In one of the embodiments, one kind in ammonium glycyrrhetate, glycyrrhetin acid esters of the licorice or
Two kinds of mixing.
In one of the embodiments, it is different to be selected from ethyl hydroxy benzoate, Chlorphenesin, Phenoxyethanol, methyl for the preservative
Mixing more than one or both of thiazolinone.
In one of the embodiments, one kind in Butylated Hydroxytoluene, butylated hydroxy anisole of the antioxidant or
Two kinds of mixing.
The preparation method of oil-in-water type menthol ointment of the present invention, comprises the following steps：
1) extracting liquorice extract, adds in qs glycerin, and stirring is suspended uniformly, then adds the purifying with glycerine equivalent
Water, is heated with stirring to 55~60 DEG C of dissolvings, obtains licorice solution；
2) camphor, menthol, blue gum leaf oil, citronella oil are taken, is heated with stirring to 40~50 DEG C of dissolvings, obtains menthol mixing
Liquid；
3) take oleaginous base, add antioxidant, be heated with stirring to 90~100 DEG C of dissolvings, insulated and stirred 10~20 minutes, so
After be cooled to less than 80 DEG C, obtain oil phase；
4) purified water of surplus is taken, adds the glycerine of surplus, is heated to 70~90 DEG C, laruyl alcohol is then added and gathers
Ether -20, allantoin, continue to be heated to 90~100 DEG C, insulated and stirred 10~20 minutes, is then cooled to 75~85 DEG C, adds third
Olefin(e) acid polymer/isoparaffin/laureth, is stirred 10~20 minutes, homogeneous 5~10 minutes, adds step 3) and obtain
Oil phase, stirring and emulsifying 10~20 minutes, homogeneous 20~30 minutes, is then cooled to less than 45 DEG C, obtains emulsifiable paste；
5) the licorice solution that vitamin E, preservative and step 1) obtain is taken, adds the emulsifiable paste that step 4) obtains
In, stir 5~10 minutes, the menthol mixed liquor that then addition step 2) obtains, stirring and emulsifying 10~20 minutes, homogeneous 20~
30 minutes, less than 40 DEG C are cooled to, discharging, obtains the oil-in-water type menthol ointment.
The present invention oil-in-water type menthol ointment, using menthol, camphor and blue gum leaf oil, licorice, vitamin E,
Allantoin is used in combination, can effectively play refrigerant, anti-inflammatory, it is antipruritic the effect of, alleviate bite by mosquitos after skin immune response release
Put the redness caused by inflammatory mediator, trace is itched problem, and can play skin the effect of conditioning, nursing, accelerate impaired flesh
The reparation of skin barrier function, makes skin keep fit.Wherein, menthol, camphor and blue gum leaf oil can stimulate skin, accelerate scorching
The blood circulation of disease tissue, promotes the immune response of immunocyte contratoxin, accelerates the elimination of inflammatory mediator；Menthol, camphor
The sensitiveness of nerve endings in skin can be reduced, mitigates pruritis, moreover it is possible to is absorbed heat by volatilizing, skin is produced refrigerant sense
Feel.Licorice has effects that anti-inflammatory, suppresses allergy, and ammonium glycyrrhetate is the principle active component of radix glycyrrhizae, can be pressed down
The activation of T lymphocyte nuclears macrophage processed, propagation, moreover it is possible to suppress lipoxygenase and epoxidase, and then suppress the life of inflammatory mediator
Into generation anti-inflammatory, anti-allergic effects；Ammonium glycyrrhetate can also mitigate the infiltration of inflammatory mediator, mitigate and inflammatory mediator of releiving is to flesh
The induced pain effect of skin.It is demonstrated experimentally that menthol, camphor and blue gum leaf oil, licorice are used in combination, peppermint can be strengthened
The effect of alcohol, camphor, so as to significantly reduce the dosage of menthol, camphor, and avoid the use of gaultherolin, Neng Gouyou
Effect reduces the irritation of this formula.And vitamin E has the function of to keep moisture of skin, nourishes rough skin, allantoin has cutin
Loosen, be hydrated, stimulation of releiving, the effect for promoting epithelial growth, vitamin E is used in combination with allantoin, can promote to be damaged flesh
The reparation of skin, recovers the barrier function of normal skin.
The oil-in-water type menthol ointment of the present invention, by adding citronella oil, can assign menthol ointment good aromatic mosquito-expelling work(
Effect.Citronella oil is herbal components, its safety, gentle, irritation is small, it is demonstrated experimentally that its mosquito repellent efficiency can reach 52.6%.
In addition, citronella oil is used in combination with menthol, camphor, moreover it is possible to relaxes the intrinsic penetrating odor of menthol, camphor, makes menthol ointment
Formula has pure and fresh, comfortable smell.
The oil-in-water type menthol ointment of the present invention, is increased using acrylate copolymer/isoparaffin/laureth as emulsification
Thick dose, it can emulsify each quasi-grease easily, from grease HLB with excellent surface-active, thickening property and hydrophilic swellability
The limitation of value, and tolerable up to 50% polyalcohol, and steadily in the long term.Acrylate copolymer/isoparaffin/laureth
After disperseing in system, laureth therein is main emulsification composition, and oil-in-water emulsion can be made to form stability pole
High emulsification system；Acrylate copolymer molecule has unique solubilized adsorption capacity, can significantly decrease interfacial free energy,
Strengthen the stability of interfacial film, strengthen the affinity of dispersed phase and scattered phase medium；In addition, acrylate copolymer molecule is denounceed because of electricity
Power opens and forms unique net structure, its net structure is distributed in whole system, can change the rheological characteristic of system, make
Lotion keeps stable denseness, and the change being resistant to below 60 DEG C of environment temperature, makes pasty consistence will not be because of environment temperature
Change and have larger fluctuation；And isoparaffin can promote acrylate copolymer to be evenly dispersed in water phase.Acroleic acid polymerization
Thing/isoparaffin/laureth can wrap up the component in inventive formulation, form stable Oil-in-water emulsifiable paste body
System, prevents the component in formula, the particularly volatile ingredient such as camphor, menthol, blue gum leaf oil from free and aggregation occurs, avoids
It destroys the stability of emulsification system because of aggregation, and avoids it that oxidation stain occurs because of segregation, so as to effectively keep away
Exempt from lotion oxidation stain and with temperature rise and the problem of thinning, condensate oil, effectively increase the steady of oil-in-water type menthol ointment
It is qualitative.It is demonstrated experimentally that by 40 DEG C of accelerated tests 6 months, the denseness of oil-in-water type menthol ointment of the invention, discoloration accord with
Close and require.
The oil-in-water type menthol ointment of the present invention, using laureth as coemulsifier, with acrylate copolymer/different
Alkane/laureth compounding use, can strengthen emulsifying effectiveness, adjust HLB value in suitable scope, make emulsification system more
Add stabilization.
The oil-in-water type menthol ointment of the present invention, using grape-kernel oil, beeswax, cetostearyl alcohol, caprylic/capric glycerine three
Ester, dimethyl silicone polymer and stearine are as oleaginous base, it is with that property is gentle, safety, irritation are low etc. is excellent
Point, and the denseness and coating of lotion can be effectively adjusted, improve greasy feeling when lotion is smeared.Beeswax therein also has profit
The effect of skin, skin care.
The oil-in-water type menthol ointment of the present invention, using glycerine as moisturizing, emollient, it is possible to increase menthol ointment is to skin
Moisten effect；Meanwhile glycerine also has the rush effect of oozing, ammonium glycyrrhetate and other functional ingredient can be promoted to permeate epidermis, promote it
Play anti-inflammatory efficacy.
The oil-in-water type menthol ointment of the present invention, using oil-in-water type matrix, effectively reduces the dosage of oleaginous base, eliminates
The greasy feeling of ointment type menthol ointment, is assigned to the splendid salubrious pro-skin sense of menthol ointment.Meanwhile in oil-in-water type matrix system,
The effect of more water soluble ingredients, such as ammonium glycyrrhetate, allantoin etc. can be added, lifting menthol ointment can be integrated.
Oil-in-water type peppermint ointment preparation of the present invention, being capable of the property prepared by the control to technological parameter
The oil-in-water type menthol ointment that matter is stablized.Wherein, in step 1), heating and temperature control is at 55~60 DEG C, if temperature is too low, radix glycyrrhizae
Extract dissolving is incomplete, if temperature is excessive, the effect of making licorice reduces, or even failure；In step 2), add
Hot temperature control avoids the components such as camphor, menthol from being volatilized at 40~50 DEG C；In step 3), step 4), 90~100
Dissolved by heating at DEG C, to ensure that each component dissolving is complete, and can fully sterilize, avoid the pollution of microorganism；In step 4),
Emulsifying temperature is controlled at 75~85 DEG C, if temperature is too low, oil phase can condense into solid-state, cause to emulsify uneven, it is difficult to be emulsified into
Paste；In step 4), step 5), homogenizing time was controlled at 20~30 minutes, if overlong time, can be broken macromolecular chain,
Cause lotion thinning or be demulsified, if the time is too short, cannot be sufficiently mixed uniformly.
Embodiment
Embodiment one：The preparation of oil-in-water type menthol ointment of the present invention
According to the formula shown in table 1 below, each component is weighed respectively.
Table 1
| Component | Dosage |
| Glycerine | 20g |
| Camphor | 1.5g |
| Menthol | 1.5g |
| Blue gum leaf oil | 1.0g |
| Ammonium glycyrrhetate | 0.6g |
| Vitamin E | 1.2g |
| Allantoin | 0.3g |
| Citronella oil | 0.8g |
| Grape-kernel oil | 4.5g |
| Beeswax | 1.2g |
| Cetostearyl alcohol | 5.5g |
| Caprylic/capric triglyceride | 4.0g |
| Dimethyl silicone polymer | 3.5g |
| Stearine | 2.0g |
| Ethyl hydroxy benzoate | 0.3g |
| Phenoxyethanol | 0.3g |
| Methylisothiazolinone | 0.008g |
| Butylated Hydroxytoluene | 0.04g |
| Laureth -20 | 2.0g |
| Ammonium polyacrylate/C13-16 isoparaffins/laureth -25 | 4.0g |
| Purified water | Add water to 100g |
Extracting liquorice acid ammonium, adds in qs glycerin, and stirring is suspended uniformly, then adds the purified water with glycerine equivalent, stirs
Mix and be heated to 55 DEG C of dissolvings, obtain licorice solution；
Camphor, menthol, blue gum leaf oil, citronella oil are taken, 45 DEG C of dissolvings is heated with stirring to, obtains menthol mixed liquor；
Take grape-kernel oil, beeswax, cetostearyl alcohol, caprylic/capric triglyceride, dimethyl silicone polymer, glyceryl stearate
Acid esters, Butylated Hydroxytoluene, are heated with stirring to 100 DEG C of dissolvings, insulated and stirred 15 minutes, is then cooled to 80 DEG C, obtains oil phase；
The purified water of surplus is taken, adds the glycerine of surplus, is heated to 80 DEG C, then adds laureth -20, urine
Bursin, continues to be heated to 100 DEG C, insulated and stirred 15 minutes, is then cooled to 80 DEG C, adds the different chains of ammonium polyacrylate/C13-16
Alkane/laureth -25, is stirred 15 minutes, homogeneous 10 minutes adds the oil phase that step 3) obtains, and stirring and emulsifying 15 is divided
Clock, homogeneous 25 minutes, is then cooled to 45 DEG C, obtains emulsifiable paste；
Take vitamin E, ethyl hydroxy benzoate, Phenoxyethanol, methylisothiazolinone, and the licorice that step 1) obtains
Solution, adds in the emulsifiable paste that step 4) obtains, and stirs 5 minutes, then adds the menthol mixed liquor that step 2) obtains, stirring breast
Change 15 minutes, homogeneous 25 minutes, be cooled to less than 38 DEG C, discharging, obtains the oil-in-water type menthol ointment.
Embodiment two：The performance test of oil-in-water type menthol ointment of the present invention
1st, stability test
1.160 DEG C of high temperature influence factor experiments
Test method：Oil-in-water type menthol ointment prepared by embodiment one is placed in 60 DEG C of insulating boxs, investigates it at 60 DEG C 3
My god, 7 days, the pH value of 14 days, the uniformity, discoloration and whether there is bleed, condensate oil, lamination, and with room temperature 0 day
Sample compares.
Result of the test：For the oil-in-water type menthol ointment of the present invention at 60 DEG C under conditions of 14 days, no bleed, condensate oil, layering are existing
As, good evenness, pH value and discoloration are compared with the room temperature sample of 0 day without significant difference.
Result of the test shows that oil-in-water type menthol ointment of the invention is resistant to certain high temperature, with good stability.
1.240 DEG C accelerated test
Test objective：Investigate the stability of product before the deadline.
Test method：Oil-in-water type menthol ointment prepared by embodiment one is placed in 40 degree of insulating boxs, investigate its 1,2,3,
4th, the pH value of 5,6 months, the uniformity, discoloration, centrifugation situation, and compared with the room temperature sample of 0 day.
Result of the test：The oil-in-water type menthol ointment of the present invention is at 40 DEG C under conditions of 6 months, good evenness, centrifuge regardless of
Layer, pH value and discoloration are compared with the room temperature sample of 0 day without significant difference.
Result of the test shows that oil-in-water type menthol ointment of the invention is not in exception before the deadline, has well
Stability.
1.3 thermal cycling test
Test objective：Investigate stability of the product under transport, exceptional condition.
Test method：By oil-in-water type menthol ointment prepared by embodiment one be placed in 60 DEG C of insulating boxs 7 it is small when, take out in room temperature
Place 17 it is small when, then proceed to be placed in 60 DEG C of insulating boxs 7 it is small when, take out room temperature place 17 it is small when, so repeatedly 9 times, investigate
Lotion recovers to character at room temperature, pH value, denseness, and is compared with the room temperature sample of 0 day.
Result of the test：For the oil-in-water type menthol ointment of the present invention after 9 cold cyclings, lotion is uniform, fine and smooth, smooth,
PH value and denseness are compared with the room temperature sample of 0 day without significant difference.
Result of the test shows that oil-in-water type menthol ointment of the invention is resistant to temperature exceptional condition fluctuated.
2nd, irritation test
Rabbit is selected to carry out skin irritation test as animal subject.Tested material is coated on to the skin of animal subject
On, the skin irritatin degree of animal subject is observed in predetermined time interval and is scored, wherein, sample sets coating is implemented
Oil-in-water type menthol ointment prepared by example one, control group coating purified water, every group of 10 animal subjects, result of the test are as shown in table 3.
Result of the test shows that oil-in-water type menthol ointment of the invention is to no skin irritation.
2 skin irritatin intensity grade of table
| Integral mean value | Stimulus intensity |
| 0~＜ 0.5 | It is nonirritant |
| 0.5~＜ 2.0 | Subexcite |
| 2.0~＜ 6.0 | Moderate stimulation |
| 6.0~8.0 | Strong and stimulating |
Table 3
3rd, skin sense is tested
50 consumers are randomly selected, respectively the oil-in-water type menthol ointment (A groups) to the present invention and commercially available conventional thin
Lotus cream (B groups) is evaluated, and evaluation score is counted, and the results are shown in Table 4.
Table 4
Remarks：Section score as 0~10 point, 0 point of expression is worst, and 10 points represent optimal.
Result of the test shows that commercially available tradition peppermint lubricate soapy feeling weight, is not easy to be absorbed by the skin after coating, and Odor stimulation
Property is big, is not easy to be esthetically acceptable to the consumers.And the oil-in-water type menthol ointment of the present invention is small with greasy feeling, residual sense is low, and coating is good,
Moisture feeling, pro-skin sense are strong, and pliability, the advantages of smoothness is good, on the whole with refrigerant, moist, comfortable skin sense.
4th, anti-inflammatory, antipruritic effect experiment
30 subjects are chosen, evaluation index is turned to the gargalesthesia of skin, red and swollen become after mosquito bite, anti-inflammatory is carried out and stops
Itch effect test.By compile it is blind in a manner of subject is randomly divided into 3 groups, wherein, sample sets are oil-in-water type prepared by embodiment one
Menthol ointment, control group are commercially available menthol ointment, and blank group is the lotion of not drug containing.Tested material is applied to by mosquito by subject
On the skin bitten, and gently rub 15 seconds, skin gargalesthesia and red and swollen degree are evaluated by subject.The scoring section of subject
For 0~5, score value is smaller, represents that gargalesthesia and red and swollen degree are smaller.Result of the test is as shown in table 5, table 6.
Table 5
By the results showed that of table 5 compared with commercially available traditional menthol ointment, oil-in-water type menthol ointment of the invention is thin
Under conditions of lotus alcohol and camphor dosage are extremely low, equally have the function that effective trace of releiving is itched, and work faster, antipruritic effect is more
Substantially.
Table 6
By the results showed that of table 6 compared with commercially available traditional menthol ointment, oil-in-water type menthol ointment of the invention is thin
Under conditions of lotus alcohol and camphor dosage are extremely low, equally have the function that effective anti-inflammatory, Polyglucan, and work faster, anti-inflammatory
Effect becomes apparent from.
5th, repelling effect is tested
In 3 closed good glass jars (30cm × 30cm × 30cm), 90 female culexs, random choosing are respectively put into
3 subjects are selected, in the different time on the experiment same day, by 0.5g/cm2The dosage oil-in-water type peppermint for preparing embodiment one
Cream is uniformly applied at the skin exposure of left hand the back of the hand 3cm × 3cm of subject, and skin tightly covers at remaining exposure, tested
Right hand the back of the hand of person is using the region of equal size as blank control, and skin tightly covers at remaining exposure.During experiment, subject
Left hand and the right hand are successively stretched into each 5min in glass jar, observation and record mosquito sting the number of thorn, and every subject repeats to survey
Examination 3 times.Test temperature is room temperature, and relative humidity is 60~70%.Result of the test is as shown in table 7.
Table 7
There is good repelling effect by the oil-in-water type menthol ointment of the results showed that present invention of table 7.
Embodiment described above only expresses the several embodiments of the present invention, its description is more specific and detailed, but simultaneously
Therefore the limitation to the scope of the claims of the present invention cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
- A kind of 1. oil-in-water type menthol ointment, by weight percentage including following components：Glycerine 15% ~ 25%,Camphor 1% ~ 2%,Menthol 1% ~ 2%,Blue gum leaf oil 1% ~ 2%,Licorice 0.3% ~ 1%,Vitamin E 0.5% ~ 2%,Allantoin 0.1% ~ 0.5%,Citronella oil 0.5% ~ 1%,Preservative 0.2% ~ 1%,Antioxidant 0.02% ~ 0.05%,Oleaginous base 13.5% ~ 29%,Laureth 1% ~ 3%,Acrylate copolymer/isoparaffin/laureth 3% ~ 5%,And the purified water of its surplus.
- 2. oil-in-water type menthol ointment according to claim 1, it is characterised in that：The acrylate copolymer/different alkane Hydrocarbon/laureth is selected from ammonium polyacrylate/C13-16 isoparaffins/laureth -25 or acrylate copolymer/ore deposit Thing oil/laureth -23.
- 3. oil-in-water type menthol ointment according to claim 1 or 2, it is characterised in that：The acrylate copolymer/different chain In alkane/laureth, acrylate copolymer, isoparaffin, the mass ratio of laureth are（5 ~ 6）︰（3 ~ 4）︰ （4 ~ 5）.
- 4. oil-in-water type menthol ointment according to claim 1, it is characterised in that：The laureth is selected from laruyl alcohol Combination more than one or both of polyethers -20, laureth -23, laureth -25.
- 5. oil-in-water type menthol ointment according to claim 1 or 2, it is characterised in that：The oleaginous base contains grape Seed oil, beeswax, cetostearyl alcohol, caprylic/capric triglyceride, dimethyl silicone polymer and stearine.
- 6. oil-in-water type menthol ointment according to claim 5, it is characterised in that according to the weight of the oil-in-water type menthol ointment Measure percentage to calculate, the oleaginous base contains：Grape-kernel oil 3% ~ 6%,Beeswax 0.5% ~ 2%,Cetostearyl alcohol 4% ~ 7%,Caprylic/capric triglyceride 3% ~ 6%,Dimethyl silicone polymer 2% ~ 5%,Stearine 1% ~ 3%.
- 7. oil-in-water type menthol ointment according to claim 1 or 2, it is characterised in that：The licorice is selected from sweet The mixing of one or both of ammonium oxalate, glycyrrhetin acid esters.
- 8. oil-in-water type menthol ointment according to claim 1 or 2, it is characterised in that：The preservative is selected from oxybenzene second Mixing more than one or both of ester, Chlorphenesin, Phenoxyethanol, methylisothiazolinone.
- 9. oil-in-water type menthol ointment according to claim 1 or 2, it is characterised in that：The antioxidant is selected from fourth hydroxyl first The mixing of one or both of benzene, butylated hydroxy anisole.
- 10. the preparation method of the oil-in-water type menthol ointment described in claim 1, comprises the following steps：1）Extracting liquorice extract, adds in qs glycerin, and stirring is suspended uniformly, then adds the purified water with glycerine equivalent, stirs Mix and be heated to 55 ~ 60 DEG C of dissolvings, obtain licorice solution；2）Camphor, menthol, blue gum leaf oil, citronella oil are taken, 40 ~ 50 DEG C of dissolvings is heated with stirring to, obtains menthol mixed liquor；3）Take oleaginous base, add antioxidant, be heated with stirring to 90 ~ 100 DEG C of dissolvings, insulated and stirred 10 ~ 20 minutes, then Less than 80 DEG C are cooled to, obtains oil phase；4）The purified water of surplus is taken, adds the glycerine of surplus, is heated to 70 ~ 90 DEG C, then adds laureth, urine Bursin, continues to be heated to 90 ~ 100 DEG C, insulated and stirred 10 ~ 20 minutes, is then cooled to 75 ~ 85 DEG C, adds acrylic acid Polymer/isoparaffin/laureth, is stirred 10 ~ 20 minutes, homogeneous 5 ~ 10 minutes, adds step 3）Obtain Oil phase, stirring and emulsifying 10 ~ 20 minutes, homogeneous 20 ~ 30 minutes, is then cooled to less than 45 DEG C, obtains emulsifiable paste；5）Take vitamin E, preservative and step 1）Obtained licorice solution, adds step 4）In obtained emulsifiable paste, Stirring 5 ~ 10 minutes, then adds step 2）Obtained menthol mixed liquor, stirring and emulsifying 10 ~ 20 minutes, homogeneous 20 ~ 30 minutes, less than 40 DEG C are cooled to, discharging, obtains the oil-in-water type menthol ointment.
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| CN105687125A (en) * | 2016-01-29 | 2016-06-22 | 王绿江 | Silica gel for treating skin diseases |
| CN107625683A (en) * | 2017-09-30 | 2018-01-26 | 肇庆高新区国专科技有限公司 | It is a kind of to releive and the ointment of skin care and preparation method thereof |
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| CN102370861A (en) * | 2011-11-10 | 2012-03-14 | 渤海造船厂集团有限公司 | Emulsifiable paste for treating infantile eczema |
| CN104013544A (en) * | 2014-05-27 | 2014-09-03 | 南通仟仟惠家化有限公司 | Mosquito repellent mint paste |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102370861A (en) * | 2011-11-10 | 2012-03-14 | 渤海造船厂集团有限公司 | Emulsifiable paste for treating infantile eczema |
| CN104013544A (en) * | 2014-05-27 | 2014-09-03 | 南通仟仟惠家化有限公司 | Mosquito repellent mint paste |
Non-Patent Citations (1)
| Title |
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| "顺峰宝宝薄荷清臀膏";康之家网上药店;《http://www.kzj365.com/goods-1000030038.html》;20130701;"药盒"图片 * |
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