CN112957283A

CN112957283A - Itching-relieving and anti-allergy plant essential oil spray and preparation method thereof

Info

Publication number: CN112957283A
Application number: CN202110227959.9A
Authority: CN
Inventors: 张容真
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-03-02
Filing date: 2021-03-02
Publication date: 2021-06-15

Abstract

The invention relates to a plant essential oil spray for relieving itching and resisting allergy and a preparation method thereof, wherein the plant essential oil spray for relieving itching and resisting allergy comprises the following raw material components: chamomile oil, lavender oil, bitter orange flower oil, an emulsifier and water. The plant essential oil spray for relieving itching and resisting allergy is light green semitransparent liquid and has the functions of diminishing inflammation, relieving itching and resisting allergy and repairing. The traditional Chinese medicine composition has the advantages of taking effect quickly, being convenient and fast, being safe, having no toxic or side effect, having no skin irritation, being applicable to infants and pregnant and lying-in women, improving the using effect and increasing the crowd acceptance; in addition, the invention has the advantages of less raw materials, simple preparation method by using three natural plant essential oils, convenient preparation and suitability for popularization and application.

Description

Itching-relieving and anti-allergy plant essential oil spray and preparation method thereof

Technical Field

The invention relates to plant essential oil spray, in particular to plant essential oil spray for relieving itching and resisting allergy and a preparation method thereof.

Background

The main components of anti-allergy products in the market are chemical components such as mineral water, hyaluronic acid, ceramide and the like, most of the anti-allergy products only have the effects of replenishing water and moisturizing, and the anti-allergy products only have the effect of moisturizing skin on inflamed and inflamed skin, so that inflammation diminishing and itching relieving can not be really achieved, and the inflamed and inflamed skin can be more serious. The anti-allergic medicine for medical use is generally a hormone product, can quickly relieve red swelling and hot pain during allergy, but cannot be used for a long time so as to avoid dependence.

The plant contains natural anti-allergic and anti-inflammatory components, such as common aromatic plants of angelica dahurica and mint in traditional Chinese medicine, can dispel wind, relieve exterior syndrome, relieve itching and promote eruption, and relieve red swelling and hot pain during allergy, and is safe and independent. The plant essential oil is a high-concentration aromatic substance extracted and purified from the plants, reserves natural components of the plants, is safe, nontoxic, free of dependence and harmless to human bodies and environment. However, a single plant or extract thereof cannot effectively relieve allergic symptoms, the skin experience is poor, the efficiency is low, and the crowd acceptance caused by the fragrance sheet ー is low.

In view of this, this patent is filed.

Disclosure of Invention

The invention aims to provide the plant essential oil spray which is easy to add into a skin care product and has the effects of relieving itching and resisting allergy, wherein natural plant essential oil is used as a main component, and the plant essential oil spray has the effects of diminishing inflammation, relieving itching and resisting allergy and repairing.

The technical scheme of the invention is as follows:

the plant essential oil spray for relieving itching and resisting allergy comprises the following raw material components: chamomile oil, lavender oil, bitter orange flower oil, an emulsifier and water.

Preferably, the plant essential oil spray for relieving itching and resisting allergy comprises the following raw materials in parts by weight: 0.2-0.4 part of chamomile oil, 0.05-0.15 part of lavender oil, 0.05-0.15 part of bitter orange flower oil, 1.0-3.0 parts of emulsifier and the balance of water.

Preferably, the plant essential oil spray for relieving itching and resisting allergy comprises the following raw materials in parts by weight: 0.2 part of chamomile oil, 0.05 part of lavender oil, 0.05 part of bitter orange flower oil, 1.0 part of emulsifier and the balance of water.

Preferably, the plant essential oil spray for relieving itching and resisting allergy comprises the following raw materials in parts by weight: 0.4 part of chamomile oil, 0.05 part of lavender oil, 0.15 part of bitter orange flower oil, 3.0 parts of emulsifier and the balance of water.

Preferably, the plant essential oil spray for relieving itching and resisting allergy comprises the following raw materials in parts by weight: 0.3 part of chamomile oil, 0.1 part of lavender oil, 0.1 part of bitter orange flower oil, 2.0 parts of emulsifier and the balance of water.

Preferably, the emulsifier is butylene glycol.

A preparation method of the plant essential oil spray for relieving itching and resisting allergy comprises the following specific steps:

(1) adding water into an emulsifying pot, heating to 78-82 deg.C, and cooling to 40-45 deg.C to obtain hot water;

(2) and (2) sequentially adding an emulsifier, chamomile oil, lavender oil and bitter orange flower oil into the hot water obtained in the step (1), stirring, emulsifying until the mixture is completely dissolved, and thus obtaining the plant essential oil spray for relieving itching and resisting allergy.

Preferably, in the step (1), water is added into the emulsifying pot, heated to 80 ℃, and then cooled to 40-45 ℃ to form hot water.

Preferably, in the step (2), the emulsifying time is 10-20 min.

Preferably, the rotating speed of the stirring is 20-30 r/min.

And after the finished product is qualified, pouring the material body into a filling machine for filling, packaging after filling, spraying a production batch number and a limit date on the product by an ink-jet printer, then performing spot inspection on the finished product, and warehousing after the finished product is qualified.

Mother chrysanthemum oil: the chamomile oil is essential oil obtained by distilling chamomile flowers in Germany. In the distillation process, after several chemical components in the plant are mixed with water vapor, chamomile azulene is generated and the essential oil is blackish green. The oil contains 40-70% chamomile azulene, and has effects of mildly diminishing inflammation, relieving pain and tranquilizing, relieving excessive histamine secretion during allergy, relieving itching and pain, stabilizing cell membrane of hypertrophic tissue, tranquilizing skin and mucosa tissue, and repairing damaged cells. The flos Matricariae Chamomillae oil also contains 16-45% bisabolol oxide, and has skin caring effects such as anti-inflammation, repairing and regenerating.

Lavender oil: lavender is a traditional aromatic plant in Europe, has strong flower fragrance and green grass fragrance, and essential oil of Lavender has the effects of relieving itching, tranquilizing, diminishing inflammation, sterilizing, repairing wound and the like. The lavender oil contains 40-50% of agilawood acetate, has extremely mild property, is skin-friendly, can quickly relieve red swelling and pruritus, and can prevent wound infection and scar.

The bitter orange flower oil is essential oil extracted from flowers of bitter orange trees, the oil yield is extremely low, and only one kilogram of essential oil can be extracted from one thousand kilograms of bitter orange flowers. The neroli oil contains more than 400 natural chemical components, the main component is linalool accounting for 35-45%, the neroli oil can promote cell regeneration, repair skin and prevent infection, the fragrance is soft and elegant, and the neroli oil has the effects of soothing and relaxing tense and anxious moods while soothing the skin.

After the raw material components of the chrysanthemum flower oil, the lavender oil and the bitter orange flower oil are compounded, the natural chemical components mutually enhance the effect, the plant essential oil spray for relieving itching and allergy has the effects of relieving itching and pain, diminishing inflammation and calming, regenerating and repairing and the like, can relieve the symptoms of itching, pain, erythema, edema, pimple and the like caused by allergy, eczema, miliaria, mosquito bites and the like, has mild and mild smell and has the effect of stabilizing the mood.

Emulsification is the effect of one liquid being dispersed uniformly as very fine droplets in another liquid that is immiscible with each other. Emulsification is a liquid-liquid interface phenomenon, in which two immiscible liquids, such as oil and water, are separated into two layers in a container, with less dense oil on the upper layer and more dense water on the lower layer. If a suitable surfactant is added, the oil is dispersed in water under vigorous stirring to form an emulsion, a process called emulsification. The invention adopts butanediol as an emulsifier and a humectant, has mild property and fresh and cool texture without stickiness, and has the function of completely dissolving the components of the chamomile oil, the lavender oil and the bitter orange flower oil in the component water to form a stable solution.

Compared with the prior art, the invention has the beneficial effects that:

the plant essential oil spray for relieving itching and resisting allergy is light green semitransparent liquid and has the functions of diminishing inflammation, relieving itching and resisting allergy and repairing. The traditional Chinese medicine composition has the advantages of taking effect quickly, being convenient and fast, being safe, having no toxic or side effect, having no skin irritation, being applicable to infants and pregnant and lying-in women, improving the using effect and increasing the crowd acceptance; in addition, the invention has the advantages of less raw materials, simple preparation method by using three natural plant essential oils, convenient preparation and suitability for popularization and application.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

In some specific embodiments, the plant essential oil spray for relieving itching and resisting allergy comprises the following raw material components in parts by weight: 0.2-0.4 part of chamomile oil, 0.05-0.15 part of lavender oil, 0.05-0.15 part of bitter orange flower oil, 1.0-3.0 parts of emulsifier and the balance of water, wherein the emulsifier is butanediol;

the preparation method of the plant essential oil spray for relieving itching and resisting allergy comprises the following specific steps:

(2) and (2) sequentially adding an emulsifier, chamomile oil, lavender oil and bitter orange flower oil into the hot water obtained in the step (1), stirring and emulsifying until the emulsifier, the chamomile oil, the lavender oil and the bitter orange flower oil are completely dissolved to obtain the plant essential oil spray for relieving itching and resisting allergy, wherein the emulsifying is carried out when the temperature is raised to 100 ℃, and stirring and emulsifying are carried out for 10-20min to obtain the plant essential oil spray for relieving itching and resisting allergy.

Some more specific examples are as follows:

example 1

The embodiment provides an itching-relieving and anti-allergy plant essential oil spray which comprises the following raw material components: 0.2g of chamomile oil, 0.05g of lavender oil, 0.05g of bitter orange flower oil, 1.0g of emulsifier and the balance of water, wherein the total amount is 100 g.

(1) adding water into an emulsifying pot, heating to 78 ℃, and then cooling to 45 ℃ to form hot water;

Example 2

The embodiment provides an itching-relieving and anti-allergy plant essential oil spray which comprises the following raw material components: 0.4g of chamomile oil, 0.05g of lavender oil, 0.15g of bitter orange flower oil and 3.0g of emulsifier, wherein the emulsifier is butanediol, and the balance is water, and the total amount is 100 g.

(1) adding water into an emulsifying pot, heating to 82 ℃, and then cooling to 40 ℃ to form hot water;

(2) and (2) sequentially adding an emulsifier, chamomile oil, lavender oil and bitter orange flower oil into the hot water obtained in the step (1), stirring and heating to 100 ℃, and stirring and emulsifying for 20min at a speed of 20 revolutions per minute to obtain the plant essential oil spray for relieving itching and resisting allergy.

Example 3

The embodiment provides an itching-relieving and anti-allergy plant essential oil spray which comprises the following raw material components: 0.3g of chamomile oil, 0.1g of lavender oil, 0.1g of bitter orange flower oil and 2.0g of emulsifier, wherein the emulsifier is butanediol, and the balance is water, and the total amount is 100 g.

(1) adding water into an emulsifying pot, heating to 80 ℃, and then cooling to 43 ℃ to form hot water;

(2) and (2) sequentially adding an emulsifier, chamomile oil, lavender oil and bitter orange flower oil into the hot water obtained in the step (1), stirring and heating to 100 ℃, and stirring and emulsifying for 15min at 30 revolutions per minute to obtain the plant essential oil spray for relieving itching and resisting allergy.

The using method comprises the following steps: the plant essential oil for relieving itching and resisting allergy provided by the invention is sprayed 10-20cm away from the affected part for 1-3 times per day.

Comparative example 1

The only difference between this comparative example and example 3 is that no chamomile oil is added to the raw materials, and no chamomile oil is added during the preparation process.

Test for antipruritic Effect

30 guinea pigs weighing between 280 and 310g were selected and randomly divided into 3 groups of blank control group, example 3 group and comparative example 1 group, each group had 10 animals, the right and back paw of each group was unhaired by 1cm × 1cm, and the corresponding samples of each group were applied to the animals, and the blank control group was applied with the same amount of distilled water. After 10 minutes, 50. mu.l/paw of histamine phosphate 0.01% was dropped to the above-mentioned site, and then the above-mentioned site was further added dropwise every 3 minutes, and the concentration of every drop was gradually increased in the order of 0.02%, 0.03% and 0.04% until the foot licking occurred, and the total amount of histamine phosphate added dropwise was recorded as scratchiness threshold, and the results are shown in Table 1.

TABLE 1 test results of antipruritic effect

Group of	Threshold of itch/μ g
		Blank control group	36.3±14.88
EXAMPLE 3 group	52.5±26.43^**
		Comparative example 1 group	37.2±21.62

Compared with the blank control group, the ratio of the active ingredients,^**p<0.01。

the result shows that the group 3 of the invention has higher itch-causing threshold which is obviously superior to the blank control group and the comparative group, and the invention has better itch-relieving effect.

Skin irritation test

1. Laboratory animal

1.1 lines and grades: new Zealand rabbits, normal grade.

1.2 quantity and sex: 4, 2 males and 2 females.

1.3 weight: 2.66-2.73 kg.

1.4 units are provided: provided by a Dongxin Hua experiment animal farm in the Huadu district of Guangzhou city (animal production license number SCXK (Guangdong) 2019-.

1.5, feeding management: new Zealand rabbits are bred in a common animal room (the experimental animals use license number: SYXK (Yue) 2016-. The animal room conditions are kept stable all the time to ensure the reliability of the test results. The granulated feed is provided by cooperative medical bioengineering, llc of Jiangsu province (quality certification number: 20200104).

2. Experimental samples example 3 of the present invention.

3. Dose design and grouping

3.1 design method according to technical Specification for safety of cosmetics 2015 edition of skin irritation/corrosivity test

3.2 dose design and grouping: according to the skin irritation/corrosivity test method of the technical Specification for cosmetic safety 2015 edition, the general-grade New Zealand rabbits qualified for quarantine are directly used for multiple skin irritation tests.

4. Experimental methods

4.1 contamination method: 4 common-grade New Zealand rabbits, each half of the female rabbit and the male rabbit. Before the test, the hair on both sides of the spine of the back of the experimental animal is cut off, and the hair removing range is about 3cm multiplied by 3cm respectively on the left side and the right side. About 0.5mL of the test substance was applied to the left skin of the animal over a 2.5cm by 2.5cm area for 1 time per day for 14 days, and the other side was used as a blank control. Shearing hair before each smearing from the next day, removing residual test substance with purified water, treating control area similarly, and observing the result after one hour.

4.2 Observation: the skin reactions were observed under natural light and skin erythema and edema were scored according to the scoring criteria given in table 2 for 14 consecutive days.

5. Determination of results

The average integral per animal per day was calculated according to the following formula, and the skin irritation intensity was determined as shown in Table 3. Average score per animal per day ═ Σ integration of erythema and edema/number of animals tested)/14.

TABLE 2 skin irritation response score

TABLE 3 skin irritation Strength grading

6. Results of the experiment

No skin irritation reactions with edema were observed in the skin of the new zealand rabbits during the observation period, and the mean value of the daily score for each animal was 0 in the sample group. According to the judgment of skin irritation/corrosivity test standard in technical Specification for cosmetic safety (2015 edition), the result shows that the skin irritation strength of the invention is nonirritant for many times. The results are shown in Table 4.

TABLE 4 results of multiple skin irritation tests of the invention on New Zealand rabbits

The tests prove that the plant essential oil spray for relieving itching and resisting allergy has the functions of diminishing inflammation, relieving itching and resisting allergy and repairing. Has no irritation to skin, and is safe and has no adverse side effects.

Anti-allergy test

The tester: healthy women of 20-50 years old, 30 people in total, all positive lactic acid stabbing pain during the first visit and screening. In the nasolabial sulcus test, 50ul of a 10% lactic acid solution was dropped on a single layer of filter paper having a diameter of 8mm, the subjects were asked to score at 30 seconds, 2.5 minutes and 5 minutes, respectively, and the scores were evaluated by averaging and scoring by 4-point method. (0 is no stabbing pain, 1 is mild stabbing pain, 2 is moderate stabbing pain, 3 is severe stabbing pain, and the stabbing pain in 2.5 minutes and 5 minutes is more than or equal to 3 in total, and is positive for lactic acid stabbing pain), 10 persons in each group are divided into 3 groups; the plant essential oil spray for relieving itching and anti-allergy obtained in examples 1 to 3 of the invention is used.

Testing parts: the face is cleaned in the morning and evening and then tried out once every day, the face is sprayed in a whole face, and the return visit is carried out after the face is tried out for 30 days;

testing indexes are as follows: a test lactic acid sting experiment was performed and cumulative scores for 2.5 minute and 5 minute stinging sensations were recorded.

The test results are shown in table 5:

TABLE 5 lactic acid stinging test results

As can be seen from Table 5, the cumulative fraction of stinging sensation for examples 1-3 decreased significantly after 30 days of continued trial use. The composition of the invention has more remarkable anti-allergy relieving effect

The plant essential oil spray for relieving itching and resisting allergy provided by the invention has more anti-allergy component types and contents, has better effects of diminishing inflammation, relieving itching and resisting allergy and repairing, and particularly has better anti-allergy effect on people with red and swollen skin. And also has moisturizing and repairing effects. Further sampling, and analyzing and detecting by a food inspection and detection center, wherein the obtained plant essential oil spray for relieving itching and resisting allergy has more linalyl acetate, linalool and bisabolol oxide. The follow-up observation shows that the plant essential oil spray for relieving itching and resisting allergy is suitable for long-term use, can be sprayed for 1-4 times per day, and has good effects of diminishing inflammation, relieving itching and resisting allergy and repairing.

For men, the age of 1 year is half, the plant essential oil spray for relieving itching and resisting allergy is matched with the sweet almond oil for use, the plant essential oil spray for relieving pain and itching, the sweet almond oil for moisturizing has a good effect on infantile eczema, and the itching is gradually faded away in the next day after the use.

For a female, a baby of 2 years old and sensitive constitution, the baby has swelling and pain after being bitten by mosquitoes, and the medicine for relieving itching and diminishing swelling does not take effect, and the plant essential oil for relieving itching and resisting allergy disclosed by the invention is sprayed for 10 minutes, so that the swelling is slowly reduced.

After the male is 2 years old and the baby finishes the gill disease vaccine for one week, a plurality of small red spots appear on the body, and after the itching-relieving and anti-allergy plant essential oil is sprayed, the symptoms are relieved; and has good effect on treating red rashes.

The itching-relieving and allergy-resisting plant essential oil spray is diluted by equal amount of purified water and then is applied in a cold compress mode, the swelling is relieved on the third day, only small red spots are left, and the red fading is completed on the fourth day.

The plant essential oil for relieving itching and resisting allergy is sprayed for 3 times a day, and the prickly heat disappears after one day. In addition, the bath lotion has good prickly heat removing effect by matching with lavender.

The male treasure is not effective when a plurality of ointments are used due to the fact that the male treasure is hot in the sky, a mask is worn, the face is allergic and eczema is generated, after 5 days, sweet almond oil is smeared after the plant essential oil for relieving itching and resisting allergy is sprayed, the face is obviously improved after three times a day and only becomes a little red, after the latter week, the face is completely faded after only the plant essential oil for relieving itching and resisting allergy is sprayed, and the face is not relapsed after two weeks.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. The plant essential oil spray for relieving itching and resisting allergy is characterized by comprising the following raw material components: chamomile oil, lavender oil, bitter orange flower oil, an emulsifier and water.

2. The plant essential oil spray for relieving itching and resisting allergy according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 0.2-0.4 part of chamomile oil, 0.05-0.15 part of lavender oil, 0.05-0.15 part of bitter orange flower oil, 1.0-3.0 parts of emulsifier and the balance of water.

3. The plant essential oil spray for relieving itching and resisting allergy according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 0.2 part of chamomile oil, 0.05 part of lavender oil, 0.05 part of bitter orange flower oil, 1.0 part of emulsifier and the balance of water.

4. The plant essential oil spray for relieving itching and resisting allergy according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 0.4 part of chamomile oil, 0.05 part of lavender oil, 0.15 part of bitter orange flower oil, 3.0 parts of emulsifier and the balance of water.

5. The plant essential oil spray for relieving itching and resisting allergy according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 0.3 part of chamomile oil, 0.1 part of lavender oil, 0.1 part of bitter orange flower oil, 2.0 parts of emulsifier and the balance of water.

6. The itch-relieving and anti-allergy plant essential oil spray according to any one of claims 1 to 5, wherein the emulsifier is butylene glycol.

7. The preparation method of the plant essential oil spray for relieving itching and allergy, which is characterized by comprising the following steps:

8. The itch-relieving and anti-allergy plant essential oil spray according to claim 7, wherein in the step (1), water is added into an emulsifying pot, heated to 80 ℃, and then cooled to 40-45 ℃ to form hot water.

9. The itch-relieving and anti-allergy plant essential oil spray according to claim 7, wherein in the step (2), the emulsification time is 10-20 min.

10. The itch-relieving and anti-allergy plant essential oil spray according to claim 9, wherein the stirring speed is 20-30 rpm.