CN109966201A - A kind of antipruritic essential oil of plant and compounding extraction process - Google Patents

A kind of antipruritic essential oil of plant and compounding extraction process Download PDF

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CN109966201A
CN109966201A CN201910234957.5A CN201910234957A CN109966201A CN 109966201 A CN109966201 A CN 109966201A CN 201910234957 A CN201910234957 A CN 201910234957A CN 109966201 A CN109966201 A CN 109966201A
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essential oil
plant
compounding
antipruritic
parts
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魏于千
张馨匀
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Abstract

The present invention relates to a kind of antipruritic essential oils of plant, in parts by weight, the raw material of the antipruritic essential oil of plant includes: 1 part of German chamomile, 1-100 parts of wormwood, 1-100 parts of honeysuckle, 1-100 parts of kuh-seng and 1-100 parts of frutus cnidii, and the compounding extraction process of the antipruritic essential oil of the plant includes: removal of impurities, the preparation of single raw material powder, compounding premix, CO2It is overcritical slightly mention, 90-110 DEG C of rectifying is extracted, distillation, which is extracted, is divided into two stages distillations: first stage distillation, and the air pressure for being passed through vapor is 0.3-0.6Mpa, distillation time 3-10min；Second stage distillation, the air pressure for being passed through vapor is 0.05-0.2Mpa, distillation time 70-120min.The antipruritic essential oil of the plant be it is pure natural, fast, mild comfortable without the addition of any chemicals, easy to use, safe, antipruritic effect, the antipruritic essential oil compounding extraction process stability of the plant is good, extraction yield is high.

Description

A kind of antipruritic essential oil of plant and compounding extraction process
Technical field
The present invention relates to a kind of antipruritic essential oil of plant and compounding extraction processes, belong to essential oil field.
Background technique
Currently, Anti-itch Products on the market mainly have drug, floral water, essential wind oil etc., wherein antipruritic drug be mostly by Chemically synthesized material composition is easy to generate stimulation to skin, causes side effect although can reach antipruritic effect, and And it is easy very dense drug taste, it has not been convenient to use；The smell of floral water and essential wind oil is pungent, has shouting pain to skin Sense, not enough mildly, and antipruritic effect is slower.So provide a kind of whole plant, it is highly-safe, using mild comfortable, antipruritic The antipruritic essential oil of the plant of excellent effect has very important value.
Plants essential oil is also known as liquid golden, be extraction the distinctive aromatic substance of plant, be taken from herbal flower, What leaf, root, bark, fruit, seed, resin etc. were extract to distill, in a manner of squeezing.Plants essential oil is by more than 100 kinds or more Ingredient constituted, certainly some be more up to it is hundreds of to thousands of constituents constitute, it is however generally that plants essential oil contains alcohols, aldehyde Class, acids, phenols, acetones, terpenes.Since essential oil volatility is high, and molecule is small, it is easy to be absorbed by the body, and can be fast Speed infiltration people's intracorporeal organ, extra ingredient is excreted, whole process only needs a few minutes, and the perfume (or spice) of plant itself Taste, also directly stimulates the secretion of pituitary gland, ferment and hormone secretion etc., and function in balanced body plays the work of beauty and skin care With.
The plants essential oil that the prior art provides is obtained from whole strain or some position purification by liquid extraction of a kind of plant, so Different folk prescription essential oils is being compounded to the compounding essential oil obtained together according to a certain percentage according to demand afterwards, such as CN108245446A, CN104274634B, CN105748321A etc., essential oil effective component obtained is more single according to the method described above The problems such as one, effect is single, and essential oil oil yield is relatively low, and active constituent content is low, and folk prescription essential oil improper use is easy to lead Skin burn is caused, when use is not mild enough, and there are safety issues.
Summary of the invention
The present invention in view of the deficienciess of the prior art, provide it is a kind of it is pure natural, without the addition of any chemicals, user Just, highly-safe, antipruritic effect is fast, the antipruritic essential oil of mild comfortable plant, while providing that a kind of stability is good, extraction yield The antipruritic essential oil of the high plant of high, significant active constituent content compounds extraction process.
The technical scheme to solve the above technical problems is that a kind of antipruritic essential oil of plant, in parts by weight, institute The raw material for stating the antipruritic essential oil of plant includes: 1 part of German chamomile, 1-100 parts of wormwood, 1-100 parts of honeysuckle, 1-100 parts of kuh-seng With 1-100 parts of frutus cnidii.
Preferably, in parts by weight, the raw material of the antipruritic essential oil of the plant includes: 1 part of German chamomile, wormwood 10 Part, 5 parts of honeysuckle, 2 parts of kuh-seng and 3 parts of frutus cnidii.
The Germany chamomile is known as the jinx of sensitive skin, improves, sensitive skin of releiving, calms down the capilary of rupture, Anti-inflammatory, antiallergy also being capable of calm mood, the body that relaxes, nervous worried with anxiety, mitigation, improvement sleep of releiving；It is described Wormwood, have Wen Jing, dry, cold dispelling, hemostasis, anti-inflammatory, relieving asthma, cough-relieving, miscarriage prevention, antiallergy the effects of；Honeysuckle has heat-clearing solution Toxic action, and honeysuckle contains the pharmacological components such as chlorogenic acid, cyanidenon glycosides, to hemolytic streptococcus, golden yellow grape The various pathogens such as coccus and infection of the upper respiratory tract Causative virus etc. have stronger inhibition, have antibacterial, anti-inflammatory, adjusting is immune etc. Effect；Kuh-seng has the effect of heat-clearing and damp-drying drug, desinsection, can remove damp-heat in lower-JIAO, and desinsection is antipruritic, has very well to pruitus Relaxation effect, also can Bergamot Mint Extract, dredge and restrain pore, remove skin endotoxin contamination, book on Chinese herbal medicine battalion abundant It supports, promotes the growth and reparation of damaged blood vessels nerve cell, restore subcutaneous capillary cell viability, skin reappears compact thin It is sliding, play the role of beauty and skin care；Cnidium fruit contain volatile oil, predominantly firpene, bank alkene, isoborneol, bergapten and Angelate etc., has effects that desinsection.The antipruritic essential oil of plant obtained by the mutual cooperation of above several raw materials, Suo Youcheng Point it is derived from natural products, no any chemicals addition using mild, can directly smear the no skin irritation of human body Or sprinkling on the skin, can have the function that Quick itch stopping, but also have both mosquito repellent, bacteriostasis, to skin have nourish, Hypo-allergenic effect, to eyes also nonirritant effect, once careless entrance, wherein also without known toxic component, and it is pregnant The special populations such as woman, children also can be used, and in addition the fragrant of the antipruritic essential oil of the plant, does not stimulate, mild lasting, give people The comfort to get close to nature, but also have the function of calm mood, nervous and anxiety of releiving, it is easy to make one quickly to calm down because of scabies The impatient sense itched and generated.
In addition, including the following steps: the invention also discloses a kind of compounding extraction process of the antipruritic essential oil of plant
(1) it cleans: will be selected by German chamomile, wormwood, honeysuckle, kuh-seng and the frutus cnidii of freeze-drying, The sundries being mingled in these natural plants, soil are removed in removal of impurities, rot the substances such as withered object, the plant for avoiding the later period from extracting Contain other impurities in antipruritic essential oil, it is ensured that the purity of the antipruritic essential oil of plant, using the plant material of freeze-drying, can maximum can Can the effective volatile ingredient retained in plant material, it is ensured that the effect of the plant extracted antipruritic essential oil and fragrance, and And it is also convenient for the crushing operation in later period；
(2) preparation of single raw material powder: respectively by after removal of impurities in step (1) German chamomile, wormwood, honeysuckle, Kuh-seng and frutus cnidii carry out low-temperature grinding, and cross 80-100 mesh respectively, obtain single raw material powder, plant material are carried out low Temperature crushes, it can be ensured that the effective component in plant material is not destroyed, and can ensure to have crushed fresh plant material Entirely, smashed raw material being crossed to 80-100 mesh respectively can remove in plant material and be not easy comminuted fibres substance, be convenient for the later period The extraction and extraction of the antipruritic essential oil of plant, the single raw material powder particle that also can ensure that is uniform, uniform convenient for compounding premix；
(3) compounding premix: by Germany chamomile obtained in step (2), wormwood, honeysuckle, kuh-seng and frutus cnidii list Kind raw material powder is that 1:1-100:1-100:1-100:1-100 carries out compounding premix according to weight ratio, obtains compounding raw material powder, The extraction of antipruritic compounding essential oil will be carried out again after each single raw material powder compounding premix, what is utilized is four properties of medicinal herb theory prescription Quantization principles, four property generally refer to tremble with fear, heat, temperature, cool four kinds of property, these four properties contain drug itself have it is all Property feature, and the tendency of Chinese medicine variation more women than men for body, cold and hot is highlighted, substantially belong to organism and mutually ties The pharmacological property embodiment after generation effect is closed, this method is mainly used in Chinese medicine, this method is applied to essential oil herein, belongs to one New thinking, new method are planted, mutually acts synergistically, can solve between various substances in thus obtained antipruritic compounding essential oil Antipruritic problem, while non-stimulated to human body, it is highly-safe using mild, it is not in that folk prescription essential oil is easy to cause skin burn The problem of；
(4) overcritical slightly to mention: the compounding raw material powder that step (3) is obtained carries out CO2Supercritical fluid extraction is planted Object crude extract yellowish-brown medicinal extract is slightly mentioned using the method for co_2 supercritical fluid extraction, is not necessarily in extraction process Chemical solvent is added, so that it is guaranteed that safety and the health of the antipruritic essential oil of plant, fundamentally avoid the residual of chemical reagent, It slightly mentioning additionally by overcritical, the volume of rectifying still used when subsequent distillation is extracted can be greatly reduced by first obtaining yellowish-brown medicinal extract, Raising extraction efficiency, it is as larger in directly only with extraction is distilled, then compounded raw material powder volume, biggish distillation still is needed, and The problem of being easy to appear mass-and heat-transfer aspect, causes extraction efficiency low, oil yield is low；
(5) distillation is extracted: the yellowish-brown medicinal extract that step (4) obtains is added in distillation still, starts to be passed through vapor, into Row steam distillation is extracted, and distillation Produced Liquid is obtained, and the distillation Produced Liquid obtains the antipruritic essential oil of plant by water-oil separating.It plants The compounding extraction process of the antipruritic essential oil of object, be divided into it is overcritical slightly propose and distill extraction, can effectively improve the oil yield of essential oil, separately Outer Plant crude extract yellowish-brown medicinal extract is in distillation extraction process, colourless sesquiterpene molecule (Matricin Cl7H22O5) lose A methyl (CH is removed3), so that matricin is transformed into chamazulene in distillation process, so that it is blue that the antipruritic essential oil of plant is presented Color has natural vivid color, and smell is fuller, and quality is higher, can play the role of it is antianaphylactic, to sensibility flesh Skin also can be used.
Preferably, in the step (3), German chamomile, wormwood, honeysuckle, kuh-seng and frutus cnidii single raw material powder Last weight ratio is 1:10:5:2:3, and in the weight ratio, the antipruritic essential oil of obtained plant, color is brighter, smell Milder more meets public hobby.
Preferably, in the step (3), the Germany chamomile, wormwood, honeysuckle, the single of kuh-seng and frutus cnidii are former Feed powder end carries out compounding mixing in cone-type mixer, and two kinds of single raw material powders for first lacking parts by weight are added to taper and mix It is mixed in conjunction machine, then adds other single raw material powders, compounding mixing is carried out using this method, is mixed more equal It is even, it is more favorable for the overcritical of later period and slightly proposes technique.
Preferably, in the step (4), CO2The extraction temperature of supercritical fluid extraction is 32-42 DEG C, CO2Fluid pressure For 11-38Mpa, CO2Flow is 10-25L/h, extraction time 40-80min.
Preferably, CO in the step (4)2The extraction temperature of supercritical fluid extraction is 35-40 DEG C, CO2Fluid pressure is 20-35Mpa, CO2Flow is 15-20L/h, extraction time 60min.
Preferably, the distillation extraction in the step (5) is divided into two stage distillations: first stage distillation is passed through water steaming The air pressure of gas is 0.3-0.6Mpa, distillation time 3-10min；Second stage distillation, the air pressure for being passed through vapor is 0.05- 0.2Mpa, distillation time 70-120min.Distillation, which is extracted, is divided into two stage distillations, controls different air pressures, can effectively mention The extraction efficiency of high antipruritic compounding essential oil, while being avoided that in rectifying still boiling explosion phenomenon occur again, it can be ensured that distillation was extracted Antipruritic compounding essential oil is steadily produced in journey.
Preferably, the temperature that the distillation is extracted is 90-110 DEG C, at such a temperature, can both enable antipruritic compounding essential oil It is enough steadily to be produced, and can be improved extraction efficiency, shorten extracting cycle.
The beneficial effects of the present invention are:
(1) the antipruritic compounding essential oil volatility is high, and infiltration rate is fast, when having extraordinary antipruritic effect, and using Mildly, nonirritant, can directly smear or spray on the skin；
(2) all the components of the antipruritic compounding essential oil be derived from it is natural, without any chemicals, in the antipruritic compounding essential oil Ingredient acts synergistically mutually, without any side effects to human body, easy to use, highly-safe；
(3) the antipruritic compounding essential oil has both mosquito repellent, antibacterial, antianaphylactic function, to staphylococcus aureus, Candida albicans Bacterium, Escherichia coli bacteriostasis rate can reach 90% or more, also there is certain nourishing effect to skin, in addition smell is mildly held Long, has the function of calm mood, nervous and anxiety of releiving；
(4) the compounding extraction process of the antipruritic compounding essential oil, the extraction efficiency of essential oil is high, and extracting cycle is short, and oil yield is high, It can reach 0.5% or more, and the oil yield of conventional German chamomile extraction process is 0.2%-0.4%, what the present invention obtained Blue is presented in antipruritic compounding essential oil, and fragrant, antipruritic effect is significant, can be worked when use in 30 seconds.
Detailed description of the invention
Fig. 1 is the gaseous mass spectrum figure of Plant crude extract yellowish-brown medicinal extract in embodiment；
Fig. 2 is the gaseous mass spectrum figure of the antipruritic essential oil of plant in embodiment.
Specific embodiment
In order to make the foregoing objectives, features and advantages of the present invention clearer and more comprehensible, below to specific reality of the invention The mode of applying is described in detail.In the following description, numerous specific details are set forth in order to facilitate a full understanding of the present invention.But The invention can be embodied in many other ways as described herein, and those skilled in the art can be without prejudice to this hair Similar improvement is done in the case where bright intension, therefore the present invention is not limited by the specific embodiments disclosed below.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool The purpose of the embodiment of body, it is not intended that in the limitation present invention.
A kind of compounding extraction process of antipruritic compounding essential oil, the specific steps are as follows:
(1) it cleans: will be selected by German chamomile, wormwood, honeysuckle, kuh-seng and the frutus cnidii of freeze-drying, Removal of impurities；
(2) preparation of single raw material powder: by German chamomile, the wormwood, honeysuckle, kuh-seng after removal of impurities in step (1) It is respectively put into Lowtemperaturepulverizer with frutus cnidii and carries out low-temperature grinding, and cross 80-100 mesh respectively, removed large particulate matter, obtain To single raw material powder；
(3) compounding premix: in parts by weight, the single raw material powder of German chamomile is first added in cone-type mixer After 2 parts of single raw material powder of 1 part and kuh-seng are mixed, 3 parts of single raw material powder, the honeysuckle of frutus cnidii are sequentially added 5 parts of single raw material powder and 10 parts of single raw material powder of wormwood mixed, obtain compounding raw material powder；
(4) overcritical slightly to mention: the compounding raw material powder that step (3) obtains is put into CO2It is carried out in supercritical extracting equipment CO2Supercritical fluid extraction, extraction temperature are 35-40 DEG C, CO2Fluid pressure is 20-35Mpa, CO2Flow is 15-20L/h, extraction Taking the time is 60min, obtains Plant crude extract yellowish-brown medicinal extract；
(5) distillation is extracted: the yellowish-brown medicinal extract that step (4) obtains being added in distillation still, starts to be passed through vapor, gas Pressure is 0.5Mpa, distillation time 8min, is then that air pressure is adjusted to 0.1Mpa by the vapor being passed through, distills under the air pressure 100min, obtains distillation Produced Liquid, and the distillation Produced Liquid obtains the antipruritic essential oil of plant, the antipruritic essence of the plant by water-oil separating The oil yield of oil is 0.58%.
30 personnel by bite by mosquitos are chosen, wherein male 15, women 15, the age 22-45 years old, patient skin table There is the obvious red and swollen symptom after bite by mosquitos in face, and has pain of itching, without significant difference in terms of the course of disease, the state of an illness.By personnel with Machine is divided into control group and test group, and control group smears commercially available common floral water, and test group smears the resulting plant of the present embodiment Antipruritic essential oil.The results show that wherein there are 13 people after smearing the antipruritic essential oil of plant of the invention in test group personnel, itch in 30 seconds After pain symptom is alleviated immediately, and control group personnel smear floral water, although also feeling cool, wherein there is the pain of itching of 14 people Symptom is not relieved in 30 seconds.It can be seen that the antipruritic essential oil of plant of the invention has obviously antipruritic effect Fruit, significant effect.
The antipruritic essential oil of plant for being obtained the present embodiment according to " cosmetics safety technical specification " (2015 editions) carries out safety Degree evaluation, specific testing result such as the following table 1:
The antipruritic essential oil Safety Assessment testing result of 1 plant of table
As can be seen from Table 1, the antipruritic essential oil of plant that the present embodiment obtains meets " cosmetics safety technical specification " The standard of (2015 editions).
The antipruritic essential oil of the plant that the present embodiment is obtained carries out cutaneous anaphylaxis test experiments, and specific experiment process is such as Under:
(1) detection environment: conventional animal room, 21-23 DEG C of room temperature, relative humidity 55-65%.
(2) regular grade New Zealand White rabbit, experimental animal weight 2.3-2.4kg experimental animal: are used.
(3) experimental animal quantity/gender: 4/♀: ♂=2:2.
(4) experimental procedure: 4 healthy adult new zealand rabbits are selected, before test for 24 hours, by experimental animal back backbone diamond wool It shaves off, prepares 2 pieces of unhairing regions, each about 3cm × 3cm in each piece of unhairing region is tried after confirmation animal skin is intact It tests；2) the antipruritic essential oil 0.5ml of above-mentioned plant is taken uniformly to be applied to the region skin of unhairing about 2.5cm × 2.5cm on the left of experimental animal On (this region is tested place), then covered with patch, then fixed with nonirritant adhesive plaster and bandage, hair-fields is gone in the other side Domain skin directly uses patch covering as control；It is removed after sticking 48 hours with warm water and remains antipruritic compounding essential oil, stopped in removing Itch the 1h after compounding essential oil, for 24 hours, 48h observation test position dermoreaction, and according to the standards of grading specification of skin wound repair Skin wound repair scoring is carried out, the rank of the antipruritic compounding essential oil to animal skin stimulus intensity, specific experiment result are evaluated Such as the following table 2:
The antipruritic essential oil of 2 plant of table is to Rabbits with Acute skin wound repair result
It can be seen from the data in Table 2 that not observing the antipruritic essential oil of the plant to rabbit intact skin in each point of observation Erythema, oedema stimulate the reaction are caused, top mean value is 0, according to skin irritatin strength grading standard, the antipruritic essential oil of the plant To the nonirritant reaction of rabbit.
In the present embodiment, the overcritical Plant crude extract yellowish-brown medicinal extract slightly raised and distillation are extracted obtained plant and are stopped Essential oil of itching carries out gas phase-Mass Spectrometer Method, related map such as Fig. 1-2, specific data such as following table 3-4:
The gas phase of 3 yellowish-brown medicinal extract of table-Mass Spectrometer Method data
The gas phase of the antipruritic essential oil of 4 plant of table-Mass Spectrometer Method data
The ingredient that can be seen that before and after distilling extraction step from the data of table 3 and table 4 has significant difference, the present embodiment It mutually acts synergistically between various composition in the antipruritic essential oil of obtained plant, there is the antipruritic essential oil of the plant extraordinary antipruritic Effect, and have both mosquito repellent, antibacterial, nourishes rough skin effect, additionally by carrying out overcritical slightly mentioning and steaming again after compounding premix The process for evaporating extraction, the antipruritic essential oil of obtained plant to skin as mild as a dove, it is nonirritant.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.

Claims (9)

1. a kind of antipruritic essential oil of plant, which is characterized in that in parts by weight, the raw material of the antipruritic essential oil of plant includes: moral 1 part of state chamomile, 1-100 parts of wormwood, 1-100 parts of honeysuckle, 1-100 parts of kuh-seng and 1-100 parts of frutus cnidii.
2. the antipruritic essential oil of a kind of plant according to claim 1, which is characterized in that in parts by weight, the plant is stopped The raw material of essential oil of itching includes: 1 part of German chamomile, 10 parts of wormwood, 5 parts of honeysuckle, 2 parts of kuh-seng and 3 parts of frutus cnidii.
3. a kind of compounding extraction process of the antipruritic essential oil of plant described in -2 any one according to claim 1, which is characterized in that packet Include following steps:
(1) it cleans: will be selected, cleaned by German chamomile, wormwood, honeysuckle, kuh-seng and the frutus cnidii of freeze-drying；
(2) preparation of single raw material powder: respectively by German chamomile, the wormwood, honeysuckle, kuh-seng after removal of impurities in step (1) Low-temperature grinding is carried out with frutus cnidii, and crosses 80-100 mesh respectively, obtains single raw material powder；
(3) compounding premix: the single of Germany chamomile obtained in step (2), wormwood, honeysuckle, kuh-seng and frutus cnidii is former Feed powder end is that 1:1-100:1-100:1-100:1-100 carries out compounding premix according to weight ratio, obtains compounding raw material powder；
(4) overcritical slightly to mention: the compounding raw material powder that step (3) is obtained carries out CO2Supercritical fluid extraction obtains plant and slightly mentions Object yellowish-brown medicinal extract；
(5) distillation is extracted: the yellowish-brown medicinal extract that step (4) obtains being added in distillation still, starts to be passed through vapor, carries out water Steam distillation is extracted, and distillation Produced Liquid is obtained, and the distillation Produced Liquid obtains the antipruritic essential oil of plant by water-oil separating.
4. a kind of compounding extraction process of the antipruritic essential oil of plant according to claim 1, which is characterized in that the step (3) in, German chamomile, wormwood, honeysuckle, kuh-seng and frutus cnidii single raw material powder weight ratio be 1:10:5:2:3.
5. a kind of compounding extraction process of the antipruritic essential oil of plant according to claim 3, which is characterized in that the step (3) in, the Germany chamomile, wormwood, honeysuckle, kuh-seng and frutus cnidii single raw material powder carried out in cone-type mixer Compounding mixing, two kinds of single raw material powders for first lacking parts by weight, which are added in cone-type mixer, to be mixed, and is then added again Enter other single raw material powders.
6. a kind of compounding extraction process of the antipruritic essential oil of plant according to claim 3, which is characterized in that the step (4) CO in2The extraction temperature of supercritical fluid extraction is 32-42 DEG C, CO2Fluid pressure is 11-38Mpa, CO2Flow is 10- 25L/h, extraction time 40-80min.
7. a kind of compounding extraction process of the antipruritic essential oil of plant according to claim 6, which is characterized in that the step (4) CO in2The extraction temperature of supercritical fluid extraction is 35-40 DEG C, CO2Fluid pressure is 20-35Mpa, CO2Flow is 15- 20L/h, extraction time 60min.
8. a kind of compounding extraction process of the antipruritic essential oil of plant according to claim 3, which is characterized in that the step (5) the distillation extraction in is divided into two stage distillations: first stage distillation, and the air pressure for being passed through vapor is 0.3-0.6Mpa, steams Evaporating the time is 3-10min；Second stage distillation, the air pressure for being passed through vapor is 0.05-0.2Mpa, distillation time 70- 120min。
9. a kind of compounding extraction process of the antipruritic essential oil of plant according to claim 7, which is characterized in that the distillation mentions The temperature taken is 90-110 DEG C.
CN201910234957.5A 2019-03-27 2019-03-27 A kind of antipruritic essential oil of plant and compounding extraction process Withdrawn CN109966201A (en)

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Publication number Priority date Publication date Assignee Title
CN110591822A (en) * 2019-09-23 2019-12-20 青岛利和生物科技有限公司 Artemisia argyi essential oil extraction method for improving active component content

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110591822A (en) * 2019-09-23 2019-12-20 青岛利和生物科技有限公司 Artemisia argyi essential oil extraction method for improving active component content

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