CN107456414A - Mosquito-repellent skin-refreshing lotion - Google Patents
Mosquito-repellent skin-refreshing lotion Download PDFInfo
- Publication number
- CN107456414A CN107456414A CN201710644783.0A CN201710644783A CN107456414A CN 107456414 A CN107456414 A CN 107456414A CN 201710644783 A CN201710644783 A CN 201710644783A CN 107456414 A CN107456414 A CN 107456414A
- Authority
- CN
- China
- Prior art keywords
- percent
- wormwood
- mosquito repellent
- milky lotion
- albolene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000077 insect repellent Substances 0.000 title claims abstract description 49
- 239000006210 lotion Substances 0.000 title claims description 39
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 37
- 239000001522 artemisia absinthium l. herb extract Substances 0.000 claims abstract description 31
- 229940119569 wormwood extract Drugs 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 18
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 17
- 229940082500 cetostearyl alcohol Drugs 0.000 claims abstract description 17
- 239000008367 deionised water Substances 0.000 claims abstract description 17
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 17
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims abstract description 17
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 17
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000008117 stearic acid Substances 0.000 claims abstract description 17
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims abstract description 17
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 14
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 13
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229940041616 menthol Drugs 0.000 claims abstract description 13
- 239000003755 preservative agent Substances 0.000 claims abstract description 9
- 230000002335 preservative effect Effects 0.000 claims abstract description 9
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 7
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 6
- 238000001704 evaporation Methods 0.000 claims description 19
- 235000011187 glycerol Nutrition 0.000 claims description 17
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 16
- 239000000686 essence Substances 0.000 claims description 16
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims description 14
- 235000003097 Artemisia absinthium Nutrition 0.000 claims description 14
- 240000001851 Artemisia dracunculus Species 0.000 claims description 14
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims description 14
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims description 14
- 239000001138 artemisia absinthium Substances 0.000 claims description 14
- 230000008020 evaporation Effects 0.000 claims description 14
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 13
- 239000000284 extract Substances 0.000 claims description 12
- 150000002989 phenols Chemical class 0.000 claims description 12
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical group OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 11
- 238000000605 extraction Methods 0.000 claims description 11
- 229960005323 phenoxyethanol Drugs 0.000 claims description 11
- 239000012141 concentrate Substances 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 239000008236 heating water Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 6
- 229920000742 Cotton Polymers 0.000 claims description 5
- 235000006708 antioxidants Nutrition 0.000 claims description 5
- 235000011837 pasties Nutrition 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 6
- 229940031098 ethanolamine Drugs 0.000 claims 3
- 230000000694 effects Effects 0.000 abstract description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract description 6
- 230000001815 facial effect Effects 0.000 abstract description 2
- 206010003399 Arthropod bite Diseases 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 229940075507 glyceryl monostearate Drugs 0.000 abstract 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 abstract 1
- 229960004063 propylene glycol Drugs 0.000 abstract 1
- 239000003871 white petrolatum Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 15
- 239000003921 oil Substances 0.000 description 12
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- 241000255925 Diptera Species 0.000 description 8
- 230000001846 repelling effect Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 4
- 240000002853 Nelumbo nucifera Species 0.000 description 4
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 4
- 210000004556 brain Anatomy 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 235000013772 propylene glycol Nutrition 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 150000002170 ethers Chemical class 0.000 description 3
- 241000256113 Culicidae Species 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 230000002688 persistence Effects 0.000 description 2
- 230000001835 salubrious effect Effects 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- WUOACPNHFRMFPN-VIFPVBQESA-N (R)-(+)-alpha-terpineol Chemical compound CC1=CC[C@H](C(C)(C)O)CC1 WUOACPNHFRMFPN-VIFPVBQESA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 238000000944 Soxhlet extraction Methods 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000013064 chemical raw material Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical class CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a mosquito-repellent toner emulsion, which comprises the following components: 0.25 to 0.30 percent of wormwood extract, 0.25 to 0.30 percent of menthol, 2.00 percent of stearic acid, 1.00 percent of glyceryl monostearate, 1.50 to 2.0 percent of cetostearyl alcohol, 1.00 to 1.50 percent of white vaseline, 1.00 percent of white oil, 0.25 to 0.25 percent of span-800.20, 4.50 to 5.00 percent of glycerol, 4.00 to 4.50 percent of 1, 2-propylene glycol, 0.2 to 0.4 percent of triethanolamine, 0.05 to 0.2 percent of preservative, 0.10 to 0.15 percent of essence, 0.01 to 0.05 percent of antioxidant and 82.00 to 84.00 percent of deionized water. The invention can keep the human skin fresh and moist and prevent mosquito bite, has durable and mild effect, can be directly applied to the skin of any part of the body and fills the blank of facial mosquito repellent products.
Description
Technical field
The present invention relates to cosmetic field, more particularly to a kind of mosquito repellent milky lotion.
Background technology
Summer day temperature raises, night bite by mosquitos, makes many people feel more worried, the female for the skin that is especially sparing of oneself
It is raw, therefore the increase of the frequency of use of various mosquito repellent articles for use.The product of mosquito repellent on skin can be directly used at present cooling ointment and each
Kind mosquito-repellent spray, but cooling ointment is big to the excitant of skin, it is impossible to the use of large area, and most mosquito-repellent spray also adds
Add substantial amounts of alcohol, it is sensitive commonly using skin can be made to become drying.Combined with repelling effect so being badly in need of a skin care, be warm
With effectively, can be in the product that any area skin large area of body uses.
The content of the invention
In order to solve the above technical problems, the present invention proposes a kind of mosquito repellent milky lotion, bite by mosquitos, while temperature can be effectively prevented
Do not stimulate, can be used in any area skin of body (including facial skin) large area, and energy Glycerin, mosquito repellent persistence
More general mosquito repellent product is more preferable, is very suitable for summer and autumn use.
The technical scheme is that：
A kind of mosquito repellent milky lotion, by mass percentage including following components：Wormwood extract 0.25%~0.30% is thin
Lotus brain 0.25%~0.30%, stearic acid 2.00%, glycerin monostearate 1.00%, cetostearyl alcohol 1.50%~2.0%,
Albolene 1.00%~1.50%, white oil 1.00%, Arlacel-80 0.20%~0.25%, glycerine 4.50%~5.00%, 1,
2- propane diols 4.00%~4.50%, triethanolamine 0.2%~0.4%, preservative 0.05%~0.2%, essence 0.10%~
0.15%, antioxidant 0.01%~0.05%, deionized water 82.00%~84.00%.
In the one or more embodiments of the present invention, the wormwood extract is that wormwood extracts to obtain by soxhlet extraction
Wormwood extract, the albolene is medical albolene.
In the one or more embodiments of the present invention, the preservative is Phenoxyethanol.
In the one or more embodiments of the present invention, the antioxidant is the 4- methylphenols of 2,6- di-t-butyls one.
In the one or more embodiments of the present invention, each component is by weight percentage：Wormwood extract 0.25% is thin
Lotus brain 0.25%, stearic acid 2.00%, glycerin monostearate 1.00%, cetostearyl alcohol 1.50%, medical albolene
1.00%, white oil 1.00%, Arlacel-80 0.20%, glycerine 5.00%, 1,2-PD 4.00%, triethanolamine 0.30%, benzene
Oxyethanol 0.15%, essence 0.10%, 2,6- di-tert-butyl-4-methy phenols 0.02%, deionized water 83.23%.
In the one or more embodiments of the present invention, each component is by weight percentage：Wormwood extract 0.30% is thin
Lotus brain 0.27%, stearic acid 2.00%, glycerin monostearate 1.00%, cetostearyl alcohol 2.0%, medical albolene
1.00%, white oil 1.00%, Arlacel-80 0.20%, glycerine 5.00%, 1,2-PD 4.00%, triethanolamine 0.30%, benzene
Oxyethanol 0.15%, essence 0.12%, 2,6- di-tert-butyl-4-methy phenols 0.02%, deionized water 82.64%.
In the one or more embodiments of the present invention, each component is by weight percentage：Wormwood extract 0.30% is thin
Lotus brain 0.30%, stearic acid 2.00%, glycerin monostearate 1.00%, cetostearyl alcohol 2.0%, medical albolene
1.50%, white oil 1.00%, Arlacel-80 0.25%, glycerine 5.00%, 1,2-PD 4.50%, triethanolamine 0.30%, benzene
Oxyethanol 0.15%, essence 0.15%, 2,6- di-tert-butyl-4-methy phenols 0.02%, deionized water 81.53%.
A kind of preparation method of above-mentioned mosquito repellent milky lotion, comprises the following steps：
1) extraction of wormwood extract
A, surname extraction
The wormwood of drying and crushing is weighed, is put into the filter paper sleeve of apparatus,Soxhlet's, is added in round-bottomed flask anhydrous
Ether, and in the fluffy cotton of small group of condenser pipe top plug one, then heating water bath, controls bath temperature at 50 DEG C or so, continuously
Siphon flows back 6 times, 8 minutes every time, obtains extract；
B, it is concentrated by evaporation
Rotary Evaporators bath temperature is first arranged to 50 DEG C, rotating speed is arranged to 100rad/min, then taking out step a
Extract adds Rotary Evaporators and is concentrated by evaporation, and ether is reclaimed；
C, evaporate
Step b concentrate is poured into evaporating dish, then evaporated using heating water bath, and need to constantly be stirred with glass bar
Mix, be heated evenly concentrate, in case liquid local heating spills；It can stop heating after liquid becomes pasty state, using remaining
Temperature evaporation obtains wormwood extract solid；
2) preparation of mosquito repellent milky lotion
By load weighted stearic acid, glycerin monostearate, cetostearyl alcohol, white oil, albolene, Arlacel-80 and resist
Oxidant is mixed and heated to 80 DEG C, as A phases；Then by load weighted deionized water, glycerine, 1,2-PD, triethanolamine
80 DEG C are mixed and heated to, as B phases；In the presence of mulser, A is added in B phases, emulsified 10 minutes；It is cooled to
At 45 DEG C or so, menthol, wormwood extract, preservative and essence are added, can be discharged after stirring.
Beneficial effects of the present invention：
1st, volatile argyi leaf oil content is more, and wherein 1.8- Cineoles account for more than 50%, and other volatile oil have α-absinthol, sesquialter
Terpenol and its ester, therefore there is the effect of mosquito repellent, wormwood extract of the invention is that laboratory carries by optimal technological parameter
System is derived from, the more commercially available height of purity, quality is more can guarantee that, reaches obvious repelling effect.
2nd, based on the unique repelling effect of wormwood extract, we combine other cosmetic materials, are made refrigerant comfortable
Milky lotion, can mosquito-proof sting make application on human skin keep salubrious simultaneously to moisten, and for more commercially available mosquito repellent product, the present invention is more
Persistently effectively.
3rd, the Flavonoid substances in wormwood have bacteriostasis, the present invention is had certain prophylactic effect, together
When can reduce formula in preservative dosage, product is not stimulated gently more, especially can be directly used for face, filled up face
The blank of portion's mosquito repellent product.
Embodiment
It is as follows, it is described further in conjunction with specific embodiments：
Embodiment one：
A kind of mosquito repellent milky lotion, each component are by weight percentage：Wormwood extract 0.25%, menthol 0.25%,
Stearic acid 2.00%, glycerin monostearate 1.00%, cetostearyl alcohol 1.50%, medical albolene 1.00%, white oil
1.00%, Arlacel-80 0.20%, glycerine 5.00%, 1,2-PD 4.00%, triethanolamine 0.30%, Phenoxyethanol
0.15%, essence 0.10%, 2,6- di-tert-butyl-4-methy phenols 0.02%, deionized water 83.23%.
The preparation method of above-mentioned mosquito repellent milky lotion, comprises the following steps：
1) extraction of wormwood extract
A, surname extraction
Weigh the wormwood of 6g drying and crushings, be put into the filter paper sleeve of apparatus,Soxhlet's, in 250mL round-bottomed flasks plus
Enter 120mL absolute ethers, and in the fluffy cotton of small group of condenser pipe top plug one, then heating water bath, controls bath temperature 50
DEG C or so, serial siphon flows back 6 times, 8 minutes every time, obtains extract；
B, it is concentrated by evaporation
Rotary Evaporators bath temperature is first arranged to 50 DEG C, rotating speed is arranged to 100rad/min, then taking out step a
Extract adds Rotary Evaporators and is concentrated by evaporation, and ether is reclaimed；
C, evaporate
Step b concentrate is poured into evaporating dish, then evaporated using heating water bath, and need to constantly be stirred with glass bar
Mix, be heated evenly concentrate, in case liquid local heating spills；It can stop heating after liquid becomes pasty state, using remaining
Temperature evaporation obtains wormwood extract solid；
2) preparation of mosquito repellent milky lotion
By load weighted stearic acid, glycerin monostearate, cetostearyl alcohol, white oil, albolene, Arlacel-80 and 2,
6- di-tert-butyl-4-methy phenols are mixed and heated to 80 DEG C, as A phases；Then by load weighted deionized water, glycerine, 1,2-
Propane diols, triethanolamine are mixed and heated to 80 DEG C, as B phases；In the presence of mulser, A is added in B phases, emulsified
10 minutes；When being cooled to 45 DEG C or so, menthol, wormwood extract, Phenoxyethanol and essence are added, regulation pH value is 6.0
~6.5, it can be discharged after stirring.
Embodiment two：
A kind of mosquito repellent milky lotion, each component are by weight percentage：Wormwood extract 0.30%, menthol 0.30%,
Stearic acid 2.00%, glycerin monostearate 1.00%, cetostearyl alcohol 2.0%, medical albolene 1.50%, white oil
1.00%, Arlacel-80 0.25%, glycerine 5.00%, 1,2-PD 4.50%, triethanolamine 0.30%, Phenoxyethanol
0.15%, essence 0.15%, 2,6- di-tert-butyl-4-methy phenols 0.02%, deionized water 81.53%.
The preparation method of above-mentioned mosquito repellent milky lotion, comprises the following steps：
1) extraction of wormwood extract
A, surname extraction
Weigh the wormwood of 6g drying and crushings, be put into the filter paper sleeve of apparatus,Soxhlet's, in 250mL round-bottomed flasks plus
Enter 120mL absolute ethers, and in the fluffy cotton of small group of condenser pipe top plug one, then heating water bath, controls bath temperature 50
DEG C or so, serial siphon flows back 6 times, 8 minutes every time, obtains extract；
B, it is concentrated by evaporation
Rotary Evaporators bath temperature is first arranged to 50 DEG C, rotating speed is arranged to 100rad/min, then taking out step a
Extract adds Rotary Evaporators and is concentrated by evaporation, and ether is reclaimed；
C, evaporate
Step b concentrate is poured into evaporating dish, then evaporated using heating water bath, and need to constantly be stirred with glass bar
Mix, be heated evenly concentrate, in case liquid local heating spills；It can stop heating after liquid becomes pasty state, using remaining
Temperature evaporation obtains wormwood extract solid；
2) preparation of mosquito repellent milky lotion
By load weighted stearic acid, glycerin monostearate, cetostearyl alcohol, white oil, albolene, Arlacel-80 and 2,
6- di-tert-butyl-4-methy phenols are mixed and heated to 80 DEG C, as A phases；Then by load weighted deionized water, glycerine, 1,2-
Propane diols, triethanolamine are mixed and heated to 80 DEG C, as B phases；In the presence of mulser, A is added in B phases, emulsified
10 minutes；When being cooled to 45 DEG C or so, menthol, wormwood extract, Phenoxyethanol and essence are added, regulation pH value is 6.0
~6.5, it can be discharged after stirring.
Embodiment three：
A kind of mosquito repellent milky lotion, each component are by weight percentage：Wormwood extract 0.30%, menthol 0.30%,
Stearic acid 2.00%, glycerin monostearate 1.00%, cetostearyl alcohol 2.0%, medical albolene 1.50%, white oil
1.00%, Arlacel-80 0.25%, glycerine 5.00%, 1,2-PD 4.50%, triethanolamine 0.30%, Phenoxyethanol
0.15%, essence 0.15%, 2,6- di-tert-butyl-4-methy phenols 0.02%, deionized water 81.53%.
The preparation method of above-mentioned mosquito repellent milky lotion, comprises the following steps：
1) extraction of wormwood extract
A, surname extraction
Weigh the wormwood of 6g drying and crushings, be put into the filter paper sleeve of apparatus,Soxhlet's, in 250mL round-bottomed flasks plus
Enter 120mL absolute ethers, and in the fluffy cotton of small group of condenser pipe top plug one, then heating water bath, controls bath temperature 50
DEG C or so, serial siphon flows back 6 times, 8 minutes every time, obtains extract；
B, it is concentrated by evaporation
Rotary Evaporators bath temperature is first arranged to 50 DEG C, rotating speed is arranged to 100rad/min, then taking out step a
Extract adds Rotary Evaporators and is concentrated by evaporation, and ether is reclaimed；
C, evaporate
Step b concentrate is poured into evaporating dish, then evaporated using heating water bath, and need to constantly be stirred with glass bar
Mix, be heated evenly concentrate, in case liquid local heating spills；It can stop heating after liquid becomes pasty state, using remaining
Temperature evaporation obtains wormwood extract solid；
2) preparation of mosquito repellent milky lotion
By load weighted stearic acid, glycerin monostearate, cetostearyl alcohol, white oil, albolene, Arlacel-80 and 2,
6- di-tert-butyl-4-methy phenols are mixed and heated to 80 DEG C, as A phases；Then by load weighted deionized water, glycerine, 1,2-
Propane diols, triethanolamine are mixed and heated to 80 DEG C, as B phases；In the presence of mulser, A is added in B phases, emulsified
10 minutes；When being cooled to 45 DEG C or so, menthol, wormwood extract, Phenoxyethanol and essence are added, regulation pH value is 6.0
~6.5, it can be discharged after stirring.
Mosquito repellent milky lotion made from embodiment one to three is tested as follows：
First, test event
1st, using skin sense effect detection：Milky lotion is applied on the skin of parts of body (including face), sees skin toner
Whether breast matter sense fine and smooth, feel whether salubrious non-greasy, whether skin assimilation effect good, if irritant etc..
2nd, centrifugation test：The height of sample about 2/3 is injected in centrifuge tube and fills reality, is stoppered with plug, 38 DEG C of water-baths 1 hour
It is transferred to immediately in centrifuge afterwards, and centrifuge is transferred to 2000r/min centrifugal speed, rotation 30min takes out observation.
3rd, pH is examined：Weigh 1g mosquito repellent milky lotion and be diluted to 10g, first with wide pH value test paper detect, after discoloration with colorimetric card
Contrast；It is 6 or so to be adjusted to pH, then is accurately detected with pH meter and draw actual pH.
4th, heat-resisting, cold-resistant test：Sample is placed under conditions of 40 DEG C and -5 DEG C respectively observation sample shape is taken out after 1 month
State.
5th, mosquito repellent is tested：The experimenter of 20 is looked for, is divided into four groups, every group of five people.Experimenter will drive in first day
Mosquito milky lotion is applied at skin exposure, and each group of people person then is sent into corresponding experiment place, waited until 30 minutes, 45 points
Clock, 60 minutes when record experimenter's upper body on mosquito bag number；Allow experimenter that commercially available mosquito-repellent water is applied into skin within second day
At skin exposure, each group of people person is then sent to corresponding experiment place, recorded when waiting until 30 minutes, 45 minutes, 60 minutes real
Test mosquito bag number in personnel's upper body；Allow experimenter that common milky lotion is applied at skin exposure within 3rd day, then will be every
Group personnel are sent to corresponding experiment place, and mosquito in experimenter's upper body is recorded when waiting until 30 minutes, 45 minutes, 60 minutes
Bag number；Allow experimenter not smear any skin care item within 4th day, each group of people person is then sent to corresponding experiment place, waited until
Mosquito bag number in experimenter's upper body is recorded at 30 minutes, 45 minutes, 60 minutes；Finally handled and correction data is drawn
Conclusion.
2nd, test result
1st, using skin sense effect detection result, as shown in table 1：
Table 1
2nd, stability test result (including centrifugation test, pH are examined, are heat-resisting, the test result of cold-resistant test), such as the institute of table 2
Show：
Table 2
3rd, mosquito repellent test result, as shown in Table 3-5：
Table 3 uses the test data table after the mosquito repellent milky lotion of embodiment one to three
Table 4 uses the test data table after commercially available mosquito-repellent water
Table 5. uses the test data table after common milky lotion
The test data table after milky lotion is not used in table 6.
Four parts of data (table 3-6) of the above are drawn by the mosquito repellent experimental test of four days, from above-mentioned four parts of data：
1st, as shown in table 1, of the invention uses skin sense effect, sensory effects etc. excellent performance, and in each portion of body
Position uses stingless excitation.
2nd, as shown in table 2, stability of the invention is high, and pH is faintly acid, is not stimulated gently.
3rd, as shown in table 5 and table 6, common milky lotion does not influence significantly on mosquito, can regard as common milky lotion and not have
There is repelling effect；
4th, the milky lotion of addition wormwood extract shown in such as table 3 and table 6 has a certain impact to mosquito, has certain drive
Mosquito effect, and the repelling effect duration is about 60 minutes or so.
5th, as shown in Table 3 and Table 4, of the invention compared with commercially available mosquito-repellent water, the repelling effect in first 30 minutes is suitable, still
The effect of 45 minutes or so commercially available mosquito-repellent waters is begun to decline, especially the open air in ventilation, because commercially available mosquito-repellent water contains largely
Volatile solvent, in the outdoor volatile failure of ventilation, so persistence is more of the invention weak.
Laboratory is applied to the mosquito repellent for making wormwood in the milky lotion in cosmetics by the present invention from the wormwood extract extracted
Effect embodies in milky lotion, turns into a kind of novel medicine adornment；And the Flavonoid substances in wormwood coordinate a small amount of preservative,
More preferable anti-oxidant, antiseptic effect can be reached, greatly reduce the injury to human body of chemical raw material.And we pass through each
Detection experiment, it has been determined that this product in physicochemical property, using skin sense effect, sensory effects etc. excellent performance, and have
The good lasting mosquito-proof effect of mosquito repellent, is the outstanding skin care item that a applicability is wide, practical.
It is that above-mentioned preferred embodiment should be regarded as application scheme embodiment for example, all with application scheme thunder
Same, approximation or the technology deduction made based on this, replacement, improvement etc., it is regarded as the protection domain of this patent.
Claims (8)
1. a kind of mosquito repellent milky lotion, it is characterised in that by mass percentage including following components：Wormwood extract 0.25%~
0.30%, menthol 0.25%~0.30%, stearic acid 2.00%, glycerin monostearate 1.00%, cetostearyl alcohol
1.50%~2.0%, albolene 1.00%~1.50%, white oil 1.00%, Arlacel-80 0.20%~0.25%, glycerine
4.50%~5.00%, 1,2-PD 4.00%~4.50%, triethanolamine 0.2%~0.4%, preservative 0.05%~
0.2%, essence 0.10%~0.15%, antioxidant 0.01%~0.05%, deionized water 82.00%~84.00%.
2. mosquito repellent milky lotion according to claim 1, it is characterised in that the wormwood extract is that wormwood carries by Soxhlet
The wormwood extract that extraction obtains is followed the example of, the albolene is medical albolene.
3. mosquito repellent milky lotion according to claim 2, it is characterised in that the preservative is Phenoxyethanol.
4. mosquito repellent milky lotion according to claim 3, it is characterised in that the antioxidant is 2,6- di-t-butyls -4-
Methylphenol.
5. mosquito repellent milky lotion according to claim 4, it is characterised in that each component is by weight percentage：Wormwood carries
Take thing 0.25%, menthol 0.25%, stearic acid 2.00%, glycerin monostearate 1.00%, cetostearyl alcohol 1.50%, doctor
With albolene 1.00%, white oil 1.00%, Arlacel-80 0.20%, glycerine 5.00%, 1,2-PD 4.00%, three ethanol
Amine 0.30%, Phenoxyethanol 0.15%, essence 0.10%, 2,6- di-tert-butyl-4-methy phenols 0.02%, deionized water
83.23%.
6. mosquito repellent milky lotion according to claim 4, it is characterised in that each component is by weight percentage：Wormwood carries
Take thing 0.30%, menthol 0.27%, stearic acid 2.00%, glycerin monostearate 1.00%, cetostearyl alcohol 2.0%, doctor
With albolene 1.00%, white oil 1.00%, Arlacel-80 0.20%, glycerine 5.00%, 1,2-PD 4.00%, three ethanol
Amine 0.30%, Phenoxyethanol 0.15%, essence 0.12%, 2,6- di-tert-butyl-4-methy phenols 0.02%, deionized water
82.64%.
7. mosquito repellent milky lotion according to claim 4, it is characterised in that each component is by weight percentage：Wormwood carries
Take thing 0.30%, menthol 0.30%, stearic acid 2.00%, glycerin monostearate 1.00%, cetostearyl alcohol 2.0%, doctor
With albolene 1.50%, white oil 1.00%, Arlacel-80 0.25%, glycerine 5.00%, 1,2-PD 4.50%, three ethanol
Amine 0.30%, Phenoxyethanol 0.15%, essence 0.15%, 2,6- di-tert-butyl-4-methy phenols 0.02%, deionized water
81.53%.
8. the preparation method of the mosquito repellent milky lotion described in a kind of claim 1-7 any one, it is characterised in that including following step
Suddenly：
1) extraction of wormwood extract
A, surname extraction
The wormwood of drying and crushing is weighed, is put into the filter paper sleeve of apparatus,Soxhlet's, absolute ether is added in round-bottomed flask,
And in the fluffy cotton of small group of condenser pipe top plug one, then heating water bath, at 50 DEG C or so, serial siphon returns control bath temperature
Stream 6 times, 8 minutes every time, obtains extract；
B, it is concentrated by evaporation
Rotary Evaporators bath temperature is first arranged to 50 DEG C, rotating speed is arranged to 100rad/min, then by step a extract
Add Rotary Evaporators to be concentrated by evaporation, and ether is reclaimed；
C, evaporate
Step b concentrate is poured into evaporating dish, then evaporated using heating water bath, and need to be stirred continuously, make concentrate by
It is hot uniform, in case liquid local heating spills；It can stop heating after liquid becomes pasty state, evaporate to obtain wormwood using residual temperature
Extract solid；
2) preparation of mosquito repellent milky lotion
By load weighted stearic acid, glycerin monostearate, cetostearyl alcohol, white oil, albolene, Arlacel-80 and anti-oxidant
Agent is mixed and heated to 80 DEG C, as A phases；Then load weighted deionized water, glycerine, 1,2-PD, triethanolamine are mixed
80 DEG C are heated to, as B phases；In the presence of mulser, A is added in B phases, emulsified 10 minutes；It is cooled to 45 DEG C
During left and right, menthol, wormwood extract, preservative and essence are added, can be discharged after stirring.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110946163A (en) * | 2019-12-31 | 2020-04-03 | 海南医学院 | Traditional Chinese medicine extract mosquito repellent cream and preparation method thereof |
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Application publication date: 20171212 |