CN105997660A - Anti-mosquito lotion - Google Patents

Anti-mosquito lotion Download PDF

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Publication number
CN105997660A
CN105997660A CN201610452777.0A CN201610452777A CN105997660A CN 105997660 A CN105997660 A CN 105997660A CN 201610452777 A CN201610452777 A CN 201610452777A CN 105997660 A CN105997660 A CN 105997660A
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parts
composition
mosquito
mixture
ingredient
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吴克
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Jiangsu Qilikang Skin Pharmaceutical Co Ltd
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Jiangsu Qilikang Skin Pharmaceutical Co Ltd
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Priority to CN201610452777.0A priority Critical patent/CN105997660A/en
Publication of CN105997660A publication Critical patent/CN105997660A/en
Priority to PCT/CN2017/086766 priority patent/WO2017219838A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/06Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/342Alcohols having more than seven atoms in an unbroken chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Dispersion Chemistry (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses an anti-mosquito lotion. The anti-mosquito lotion is prepared from, by mass, an ingredient A, an ingredient B, an ingredient C and an ingredient D, wherein in the ingredient A, the ratio of linalool to citronellol to geraniol is 1:1:1 to 1:2:2; the ingredient B is folium artemisiae argyi essential oil; the ingredient C is prepared from 2-5 parts of lecithin, 0.001-0.1 part of ephedrine, 0.5-1 part of poria cocos extract, 2-10 parts of natural squalane and 1-5 parts of VE or VE derivatives; the ingredient D is prepared from 8-18 parts of glycerol and the balance water. The ingredient A and the ingredient B are mixed to be uniform in the proportion of 1:4 to 2:3; after the ingredient C and the ingredient D are mixed to be uniform, the mixture of the ingredient A and the ingredient B is added, then 6-12 parts of emulgator, 0.2-0.5 part of a surface active agent and 3.8-10 parts of consistence regulator are added; the ratio of the mixture of the ingredient A and the ingredient B to the mixture of the ingredient C and the ingredient D is 1:5 to 2:5. The anti-mosquito ingredients are wrapped by the essential oil with good compatibility with skin, an adsorption layer with good compatibility with the skin is formed, and therefore the manufactured anti-mosquito lotion is suitable of being used on the surface of the skin.

Description

Mosquito-proof emulsion
Technical field
The present invention relates to a kind of functional type emulsion.It is more particularly related to a kind of mosquito-proof emulsion.
Background technology
Mosquito, belongs to Insecta Diptera Dulicidae, is a kind of fine winged insect with sucking mouth parts.The most female using blood as food, the juice of male then sucking plant.The female mosquito sucked blood is the vector of the multiple pathogens such as dengue fever, malaria, yellow fever, filaricide, Japanese encephalitis.And on the earth in addition to the Antarctic Continent, all there is the distribution of mosquito in other each continents.
In general, mosquito is liked biting body constitution is weakly acidic people.After mosquito bite, human body skin would generally occur redness, itch, the symptom such as pain, the bad people of skin skin quality there will be more serious symptoms, such as: locally pruritus;Little red pimple occurs;Occur stining trace, i.e. smooth, protruding, rubescent skin or firmly swell.
Summer is the best opportunity that this kind of bloodsucker of mosquito breeds, and it is strong especially that it gives birth to fertility in summer, and summer is more due to people's outdoor activities, and how all to wear very little clothes, and particularly extremity often expose, summer by mosquito bite the most generally, the most common.Mosquito proof is bitten and is seemed necessary.
All kinds of medication for driving mosquitoes sold currently on the market, many employing chemical compositions are made, and not only have certain side effect, and environment is also resulted in pollution, it is while reaching mosquito killing worm effect, also constitutes the injury to people, especially the respiratory tract of people is constituted harmful effect.This chemical agent mosquito killing worm effect is the best, and its side effect is the biggest, is therefore difficult to use in a large number.As commonly used floral water, although be only made up of Chinese medicine and spice, mosquito dispersing is had certain effect, but its high volatility, and persistence is of short duration, uses rear skin breathability poor, needs to clean in time.
China Patent No. a kind of multi-effect mosquito-repellent liquid medicine that has been the disclosure of the invention of CN102018004A, mixed by diethyltoluamide, citronella oil, eucalyptus oil, tea tree oil, Pyrethrum vinegar, litsea cubeba oil six component spice, mosquito repellent time of the present invention is long, there is sterilization, the effect of air of sterilizing, purify simultaneously, but its persistency is poor, need repeatedly to smear;The China Patent No. one that has been the disclosure of the invention of CN102579288A can direct acting mosquito dispersing natural plant essential oil composition, it is made up of Oleum lavandula angustifolia, Indian oil of verbena, basil oil, Flos Matricariae chamomillae oil, Oleum menthae, eucalyptus globolus oil, tea tree oil, lemongrass oil, thyme oil, glycerol, ethanol, this invention can effectively play mosquito-repelling function, but effective percentage is the highest, and skin is easily damaged by life-time service ethanol.China Patent No. a kind of be the disclosure of the invention of CN101233864 mosquito-repellent essential oil compositions and anophelifuge method, by Oleum Caryophylli, litsea cubeba oil, form by leaf oil, purebred Lignum cinnamomi camphorae leaf oil, thyme oil, citronella oil, Oleum Pelargonii Graveolentis, Oleum lavandula angustifolia, wintergreen oil, Oleum menthae, Oleum Cinnamomi, Cedar oil, Michelia leap oil, Rue oil., Oleum Rosae Rugosae, tea tree oil, these technical scheme raw material sources are complicated, cost is high, and anophelifuge aggregate efficiency is notable not as good as the present invention.
Mostly existing anophelifuge is that being coated on skin surface as functional product plays mosquito-proof effect, do not consider the comfortableness of skin, after erasing, often there are the problems such as poor air permeability in skin, with skin-friendliness is poor, the composition with anti-mosquito function is prepared as the emulsion of suitable human body skin, then can solve that anophelifuge is volatile, need to repeatedly smear and the problem such as skin bad adaptability.
Summary of the invention
It is an object of the invention to solve at least the above, and the advantage that at least will be described later is provided.
It is a still further object of the present invention to provide a kind of mosquito-proof emulsion, it uses the quintessence oil with skin-friendliness is good to be wrapped in outside mosquito-proof composition, is formed and the preferable adsorption layer of skin-friendliness, makes the mosquito-proof emulsion skin surface preferably prepared use.
In order to realize object of the present invention and further advantage, it is provided that a kind of mosquito-proof emulsion, it comprises following component (in parts by weight):
Composition A: linalool: citronellol: geraniol is 1:1:1~1:2:2;
Composition B: P-Cymene;
Composition C: lecithin, 2~5 parts;Ephedrine, 0.001~0.1 part;Poria extract, 0.5~1 part;Natural squalane, 2~10 parts;VE or VE derivant, 1~5 part;
Components D: glycerol, 8~18 parts;Surplus is water;
Wherein composition A is mixed homogeneously with 1:4~2:3 ratio with composition B;After composition C is mixed homogeneously with components D, the mixture of composition A and composition B is added, adds emulsifying agent 6~12 parts, surfactant 0.2~0.5 part, consistency modifiers 3.8~10 parts;The mixture of composition A and composition B: composition C is 1:5~2:5 with the mixture of components D.
Preferably, described mosquito-proof emulsion, wherein, comprise following component (in parts by weight):
Linalool, 2 parts;
Citronellol, 2 parts;
Geraniol, 2 parts;
P-Cymene, 9 parts;
Lecithin, 2 parts;
Poria extract, 0.5 part;
Natural squalane, 2 parts;
VE or VE derivant, 1 part;
Ephedrine, 0.1 part;
Glycerol, 18 parts;
Emulsifying agent, 6 parts;
Surfactant, 0.2 part;
Consistency modifiers, 3.8 parts;
Surplus is water.
Preferably, described mosquito-proof emulsion, wherein, comprise following component (in parts by weight):
Linalool, 0.7 part;
Citronellol, 1.4 parts;
Geraniol, 1.4 parts;
P-Cymene, 14 parts;
Lecithin, 5 parts;
Poria extract, 1 part;
Natural squalane, 10 parts;
VE or VE derivant, 5 parts;
Ephedrine, 0.001 part;
Glycerol, 8 parts;
Emulsifying agent, 12 parts;
Surfactant, 0.5 part;
Consistency modifiers, 10 parts;
Surplus is water.
Preferably, described mosquito-proof emulsion, wherein, comprise following component (in parts by weight):
Linalool, 2 parts;
Citronellol, 3 parts;
Geraniol, 3 parts;
P-Cymene, 16 parts;
Lecithin, 3 parts;
Poria extract, 0.7 part;
Natural squalane, 8 parts;
VE or VE derivant, 3 parts;
Ephedrine, 0.05 part;
Glycerol, 15 parts;
Emulsifying agent, 9 parts;
Surfactant, 0.4 part;
Consistency modifiers, 6.6 parts;
Surplus is water.
Preferably, described mosquito-proof emulsion, wherein, described VE derivant is vitamin E acetate.
Preferably, described mosquito-proof emulsion, wherein, the mixing of described composition A and described composition B generates steam particularly as follows: use distilled water that Folium Artemisiae Argyi carries out distillation, persistently high-temperature steam is passed through in the container holding a certain amount of linalool, citronellol and geraniol in 8~10 days, carry out being mixed to form described composition A by being mixed with the linalool of steam, citronellol and geraniol, described composition A is mixed homogeneously with described composition B.
Preferably, described mosquito-proof emulsion, wherein, the mixing of described composition C and described components D, particularly as follows: take a certain amount of VE or VE derivant, is soaked in a small amount of glycerol 2~5 days, is added thereto to ephedrine;A certain amount of lecithin, Poria extract and natural squalane are sequentially added in glycerol, soak 2~5 days, vibrate every day 3~6 times, each 5~10 minutes;The glycerol mixture containing VE or VE derivant adding ephedrine is rapidly joined to the glycerol mixture containing lecithin, Poria extract and natural squalane, add suitable quantity of water, vibrating 10~30 minutes, temperature is 20~40 DEG C, obtains the mixture of described composition C and described components D.
Preferably, described mosquito-proof emulsion, wherein, the mixture of prepared described composition A and described composition B is remixed with the mixture of described composition C and described components D, under pressure is 0.5~1.33kPa, is heated to 100~120 DEG C, after continuing 3~10 minutes, it is cooled to 60~70 DEG C, mixed liquor is carried out filter and remove residue, then carries out high pressure steam sterilization, obtain the emulsion that mosquito control is bitten.
Preferably, described mosquito-proof emulsion, wherein, also include Stigma Croci.
Preferably, described mosquito-proof emulsion, wherein, take Stigma Croci described in 0.2~1g to be soaked in 200~600mL water, after soaking 20~40 minutes, heating infusion remains 60~200mL to water, and with mass ratio as 1:5~1:8 adds to the mixture of described composition A and composition B to take upper liquid.
The present invention at least includes following beneficial effect:
1, use linalool, citronellol and geraniol as mosquito-proof main function composition, with distilled water, Folium Artemisiae Argyi is carried out distillation and generate steam, steam is utilized to fumigate linalool, citronellol and geraniol, make linalool, citronellol and geraniol merge Folium Artemisiae Argyi active component, thus suitable human body skin directly contacts;
2, mix by a certain percentage through linalool, citronellol and geraniol that Folium Artemisiae Argyi steam fumigating is steamed, the mosquito-proof effect of anophelifuge, again suitable skin surface Long Term Contact can be reached;
3, P-Cymene mixes with linalool, citronellol and geraniol, and P-Cymene is coated on outside linalool, citronellol and geraniol molecule, forms the functional molecular of appropriate contact skin;
4, lecithin, Poria extract and natural squalane can strengthen skin from defence capability, skin can be strengthened again for P-Cymene, linalool, citronellol and the adaptability of geraniol blending constituent, enhancing functional component, in the absorption of skin surface, makes emulsion have lasting repelling effect;
5, VE or the VE derivant adding ephedrine is active component, and it can activate the mixture of composition C and components D for the activity of composition A Yu composition B mixture, keeps it the most functional, delays it to discharge, the persistency of enhancing emulsion and the adsorptivity at skin surface;
6, quantitative Stigma Croci supernatant is added to the mixture of described composition A and composition B, make Stigma Croci be adsorbed in P-Cymene molecular surface, improve and embrocate the comfortableness of skin after emulsion.
Part is embodied by the further advantage of the present invention, target and feature by description below, and part is also by by being understood by the person skilled in the art the research of the present invention and practice.
Detailed description of the invention
The present invention is described in further detail below, to make those skilled in the art can implement according to this with reference to description word.
Should be appreciated that used herein such as " have ", other element one or more or the existence of a combination thereof or interpolation do not allotted in " comprising " and " including " term.
The present invention provides a kind of mosquito-proof emulsion, and it comprises following component (in parts by weight):
Composition A: linalool: citronellol: geraniol is 1:1:1~1:2:2;
Composition B: P-Cymene;
Composition C: lecithin, 2~5 parts;Ephedrine, 0.001~0.1 part;Poria extract, 0.5~1 part;Natural squalane, 2~10 parts;VE or VE derivant, 1~5 part;
Components D: glycerol, 8~18 parts;Surplus is water;
Wherein composition A is mixed homogeneously with 1:4~2:3 ratio with composition B;After composition C is mixed homogeneously with components D, the mixture of composition A and composition B is added, adds emulsifying agent 6~12 parts, surfactant 0.2~0.5 part, consistency modifiers 3.8~10 parts;The mixture of composition A and composition B: composition C is 1:5~2:5 with the mixture of components D.
Wherein, described VE derivant is vitamin E acetate.
The mixing of described composition A and described composition B generates steam particularly as follows: use distilled water that Folium Artemisiae Argyi carries out distillation, persistently high-temperature steam is passed through in the container holding a certain amount of linalool, citronellol and geraniol in 8~10 days, carry out being mixed to form described composition A by being mixed with the linalool of steam, citronellol and geraniol, described composition A is mixed homogeneously with described composition B.
The mixing of described composition C and described components D, particularly as follows: take a certain amount of VE or VE derivant, is soaked in a small amount of glycerol 2~5 days, is added thereto to ephedrine;A certain amount of lecithin, Poria extract and natural squalane are sequentially added in glycerol, soak 2~5 days, vibrate every day 3~6 times, each 5~10 minutes;The glycerol mixture containing VE or VE derivant adding ephedrine is rapidly joined to the glycerol mixture containing lecithin, Poria extract and natural squalane, add suitable quantity of water, vibrating 10~30 minutes, temperature is 20~40 DEG C, obtains the mixture of described composition C and described components D.
The mixture of prepared described composition A and described composition B is remixed with the mixture of described composition C and described components D, 100~120 DEG C it are heated under pressure is 0.5~1.33kPa, after continuing 3~10 minutes, it is cooled to 60~70 DEG C, mixed liquor is carried out filter and remove residue, carry out high pressure steam sterilization again, obtain the emulsion that mosquito control is bitten.
Concrete application is as follows:
Embodiment 1
Linalool, 2 parts;
Citronellol, 2 parts;
Geraniol, 2 parts;
P-Cymene, 9 parts;
Lecithin, 2 parts;
Poria extract, 0.5 part;
Natural squalane, 2 parts;
VE or VE derivant, 1 part;
Ephedrine, 0.1 part;
Glycerol, 18 parts;
Emulsifying agent, 6 parts;
Surfactant, 0.2 part;
Consistency modifiers, 3.8 parts;
Surplus is water.
Wherein, described VE derivant is vitamin E acetate.
The mixing of described composition A and described composition B generates steam particularly as follows: use distilled water that Folium Artemisiae Argyi carries out distillation, persistently high-temperature steam is passed through in the container holding a certain amount of linalool, citronellol and geraniol in 9 days, carry out being mixed to form described composition A by being mixed with the linalool of steam, citronellol and geraniol, described composition A is mixed homogeneously with described composition B.
The mixing of described composition C and described components D, particularly as follows: take a certain amount of VE or VE derivant, is soaked in a small amount of glycerol 4 days, is added thereto to ephedrine;A certain amount of lecithin, Poria extract and natural squalane are sequentially added in glycerol, soak 4 days, vibrate every day 5 times, each 7 minutes;The glycerol mixture containing VE or VE derivant adding ephedrine is rapidly joined to the glycerol mixture containing lecithin, Poria extract and natural squalane, add suitable quantity of water, vibrating 20 minutes, temperature is 30 DEG C, obtains the mixture of described composition C and described components D.
The mixture of prepared described composition A and described composition B is remixed with the mixture of described composition C and described components D, 110 DEG C it are heated under pressure is 1.1kPa, after continuing 8 minutes, it is cooled to 65 DEG C, mixed liquor is carried out filter and remove residue, carry out high pressure steam sterilization again, obtain the emulsion that mosquito control is bitten.
Embodiment 2
Linalool, 0.7 part;
Citronellol, 1.4 parts;
Geraniol, 1.4 parts;
P-Cymene, 14 parts;
Lecithin, 5 parts;
Poria extract, 1 part;
Natural squalane, 10 parts;
VE or VE derivant, 5 parts;
Ephedrine, 0.001 part;
Glycerol, 8 parts;
Emulsifying agent, 12 parts;
Surfactant, 0.5 part;
Consistency modifiers, 10 parts;
Surplus is water;
Wherein, described VE derivant is vitamin E acetate.
The mixing of described composition A and described composition B generates steam particularly as follows: use distilled water that Folium Artemisiae Argyi carries out distillation, persistently high-temperature steam is passed through in the container holding a certain amount of linalool, citronellol and geraniol in 8 days, carry out being mixed to form described composition A by being mixed with the linalool of steam, citronellol and geraniol, described composition A is mixed homogeneously with described composition B.
The mixing of described composition C and described components D, particularly as follows: take a certain amount of VE or VE derivant, is soaked in a small amount of glycerol 2 days, is added thereto to ephedrine;A certain amount of lecithin, Poria extract and natural squalane are sequentially added in glycerol, soak 2 days, vibrate every day 3 times, each 5 minutes;The glycerol mixture containing VE or VE derivant adding ephedrine is rapidly joined to the glycerol mixture containing lecithin, Poria extract and natural squalane, add suitable quantity of water, vibrating 10 minutes, temperature is 20 DEG C, obtains the mixture of described composition C and described components D.
The mixture of prepared described composition A and described composition B is remixed with the mixture of described composition C and described components D, 100 DEG C it are heated under pressure is 0.5Pa, after continuing 3 minutes, it is cooled to 60 DEG C, mixed liquor is carried out filter and remove residue, carry out high pressure steam sterilization again, obtain the emulsion that mosquito control is bitten.
Embodiment 3
Linalool, 2 parts;
Citronellol, 3 parts;
Geraniol, 3 parts;
P-Cymene, 16 parts;
Lecithin, 3 parts;
Poria extract, 0.7 part;
Natural squalane, 8 parts;
VE or VE derivant, 3 parts;
Ephedrine, 0.05 part;
Glycerol, 15 parts;
Emulsifying agent, 9 parts;
Surfactant, 0.4 part;
Consistency modifiers, 6.6 parts;
Surplus is water;
Wherein, described VE derivant is vitamin E acetate.
The mixing of described composition A and described composition B generates steam particularly as follows: use distilled water that Folium Artemisiae Argyi carries out distillation, persistently high-temperature steam is passed through in the container holding a certain amount of linalool, citronellol and geraniol in 10 days, carry out being mixed to form described composition A by being mixed with the linalool of steam, citronellol and geraniol, described composition A is mixed homogeneously with described composition B.
The mixing of described composition C and described components D, particularly as follows: take a certain amount of VE or VE derivant, is soaked in a small amount of glycerol 5 days, is added thereto to ephedrine;A certain amount of lecithin, Poria extract and natural squalane are sequentially added in glycerol, soak 5 days, vibrate every day 6 times, each 10 minutes;The glycerol mixture containing VE or VE derivant adding ephedrine is rapidly joined to the glycerol mixture containing lecithin, Poria extract and natural squalane, add suitable quantity of water, vibrating 30 minutes, temperature is 40 DEG C, obtains the mixture of described composition C and described components D.
The mixture of prepared described composition A and described composition B is remixed with the mixture of described composition C and described components D, 120 DEG C it are heated under pressure is 1.33kPa, after continuing 10 minutes, it is cooled to 70 DEG C, mixed liquor is carried out filter and remove residue, carry out high pressure steam sterilization again, obtain the emulsion that mosquito control is bitten.
Embodiment 4
Linalool, 2 parts;
Citronellol, 2 parts;
Geraniol, 2 parts;
P-Cymene, 9 parts;
Lecithin, 2 parts;
Poria extract, 0.5 part;
Natural squalane, 2 parts;
VE or VE derivant, 1 part;
Ephedrine, 0.1 part;
Glycerol, 18 parts;
Emulsifying agent, 6 parts;
Surfactant, 0.2 part;
Consistency modifiers, 3.8 parts;
Surplus is water.
Wherein, described VE derivant is vitamin E acetate.
The mixing of described composition A and described composition B generates steam particularly as follows: use distilled water that Folium Artemisiae Argyi carries out distillation, persistently high-temperature steam is passed through in the container holding a certain amount of linalool, citronellol and geraniol in 9 days, carry out being mixed to form described composition A by being mixed with the linalool of steam, citronellol and geraniol, described composition A is mixed homogeneously with described composition B.
Taking Stigma Croci described in 0.2g to be soaked in 200mL water, after soaking 20 minutes, heating infusion remains 60mL to water, takes upper liquid and adds to the mixture of described composition A and composition B for 1:5 with mass ratio.
The mixing of described composition C and described components D, particularly as follows: take a certain amount of VE or VE derivant, is soaked in a small amount of glycerol 4 days, is added thereto to ephedrine;A certain amount of lecithin, Poria extract and natural squalane are sequentially added in glycerol, soak 4 days, vibrate every day 5 times, each 7 minutes;The glycerol mixture containing VE or VE derivant adding ephedrine is rapidly joined to the glycerol mixture containing lecithin, Poria extract and natural squalane, add suitable quantity of water, vibrating 20 minutes, temperature is 30 DEG C, obtains the mixture of described composition C and described components D.
The prepared described composition A containing Stigma Croci and the mixture of described composition B are remixed with the mixture of described composition C and described components D, 110 DEG C it are heated under pressure is 1.1kPa, after continuing 8 minutes, it is cooled to 65 DEG C, mixed liquor is carried out filter and remove residue, carry out high pressure steam sterilization again, obtain the emulsion that mosquito control is bitten.
Embodiment 5
Linalool, 2 parts;
Citronellol, 3 parts;
Geraniol, 3 parts;
P-Cymene, 16 parts;
Lecithin, 3 parts;
Poria extract, 0.7 part;
Natural squalane, 8 parts;
VE or VE derivant, 3 parts;
Ephedrine, 0.05 part;
Glycerol, 15 parts;
Emulsifying agent, 9 parts;
Surfactant, 0.4 part;
Consistency modifiers, 6.6 parts;
Surplus is water;
Wherein, described VE derivant is vitamin E acetate.
The mixing of described composition A and described composition B generates steam particularly as follows: use distilled water that Folium Artemisiae Argyi carries out distillation, persistently high-temperature steam is passed through in the container holding a certain amount of linalool, citronellol and geraniol in 10 days, carry out being mixed to form described composition A by being mixed with the linalool of steam, citronellol and geraniol, described composition A is mixed homogeneously with described composition B.
Taking Stigma Croci described in 1g to be soaked in 600mL water, after soaking 40 minutes, heating infusion remains 200mL to water, takes upper liquid and adds to the mixture of described composition A and composition B for 1:8 with mass ratio.
The mixing of described composition C and described components D, particularly as follows: take a certain amount of VE or VE derivant, is soaked in a small amount of glycerol 5 days, is added thereto to ephedrine;A certain amount of lecithin, Poria extract and natural squalane are sequentially added in glycerol, soak 5 days, vibrate every day 6 times, each 10 minutes;The glycerol mixture containing VE or VE derivant adding ephedrine is rapidly joined to the glycerol mixture containing lecithin, Poria extract and natural squalane, add suitable quantity of water, vibrating 30 minutes, temperature is 40 DEG C, obtains the mixture of described composition C and described components D.
The prepared described composition A containing Stigma Croci and the mixture of described composition B are remixed with the mixture of described composition C and described components D, 120 DEG C it are heated under pressure is 1.33kPa, after continuing 10 minutes, it is cooled to 70 DEG C, mixed liquor is carried out filter and remove residue, carry out high pressure steam sterilization again, obtain the emulsion that mosquito control is bitten.
The emulsion that embodiment 1, embodiment 2 and embodiment 3 prepare is compared with the mosquito-proof water being commercially available for body surface, the skin-friendliness of embodiment 1,2,3 product is significantly better than existing mosquito-proof water, and finds the emulsion persistency in embodiment 1 > embodiment 3 > embodiment 2.
The emulsion that embodiment 1, embodiment 4 and embodiment 5 prepare is rubbed in body surface, compares discovery embodiment 4 and embodiment 5 emulsion comfortableness relatively embodiment 1 comfortableness performs better.
Number of devices described herein and treatment scale are used to the explanation of the simplification present invention.Application, the modifications and variations of the present invention be will be readily apparent to persons skilled in the art.
Although embodiment of the present invention are disclosed as above, but it is not restricted in description and embodiment listed utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, it is easily achieved other amendment, therefore, under the general concept limited without departing substantially from claim and equivalency range, the present invention is not limited to specific details.

Claims (10)

1. a mosquito-proof emulsion, it is characterised in that comprise following component (in parts by weight):
Composition A: linalool: citronellol: geraniol is 1:1:1~1:2:2;
Composition B: P-Cymene;
Composition C: lecithin, 2~5 parts;Ephedrine, 0.001~0.1 part;Poria extract, 0.5~1 part;Natural angle Shark alkane, 2~10 parts;VE or VE derivant, 1~5 part;
Components D: glycerol, 8~18 parts;Surplus is water;
Wherein composition A is mixed homogeneously with 1:4~2:3 ratio with composition B;After composition C is mixed homogeneously with components D, will become The mixture dividing A and composition B adds, and adds emulsifying agent 6~12 parts, surfactant 0.2~0.5 part, denseness tune Joint agent 3.8~10 parts;The mixture of composition A and composition B: composition C is 1:5~2:5 with the mixture of components D.
Mosquito-proof emulsion the most as claimed in claim 1, it is characterised in that comprise following component (in parts by weight):
Linalool, 2 parts;
Citronellol, 2 parts;
Geraniol, 2 parts;
P-Cymene, 9 parts;
Lecithin, 2 parts;
Poria extract, 0.5 part;
Natural squalane, 2 parts;
VE or VE derivant, 1 part;
Ephedrine, 0.1 part;
Glycerol, 18 parts;
Emulsifying agent, 6 parts;
Surfactant, 0.2 part;
Consistency modifiers, 3.8 parts;
Surplus is water.
Mosquito-proof emulsion the most as claimed in claim 1, it is characterised in that comprise following component (in parts by weight):
Linalool, 0.7 part;
Citronellol, 1.4 parts;
Geraniol, 1.4 parts;
P-Cymene, 14 parts;
Lecithin, 5 parts;
Poria extract, 1 part;
Natural squalane, 10 parts;
VE or VE derivant, 5 parts;
Ephedrine, 0.001 part;
Glycerol, 8 parts;
Emulsifying agent, 12 parts;
Surfactant, 0.5 part;
Consistency modifiers, 10 parts;
Surplus is water.
Mosquito-proof emulsion the most as claimed in claim 1, it is characterised in that comprise following component (in parts by weight):
Linalool, 2 parts;
Citronellol, 3 parts;
Geraniol, 3 parts;
P-Cymene, 16 parts;
Lecithin, 3 parts;
Poria extract, 0.7 part;
Natural squalane, 8 parts;
VE or VE derivant, 3 parts;
Ephedrine, 0.05 part;
Glycerol, 15 parts;
Emulsifying agent, 9 parts;
Surfactant, 0.4 part;
Consistency modifiers, 6.6 parts;
Surplus is water.
5. the mosquito-proof emulsion as described in any one of Claims 1-4, it is characterised in that described VE derivant is VE vinegar Acid esters.
Mosquito-proof emulsion the most as claimed in claim 5, it is characterised in that the mixing tool of described composition A and described composition B Body is: use distilled water Folium Artemisiae Argyi is carried out distillation generate steam, persistently high-temperature steam is passed through in 8~10 days hold a certain amount of In the container of linalool, citronellol and geraniol, it is mixed to form being mixed with the linalool of steam, citronellol and geraniol Described composition A, mixs homogeneously described composition A with described composition B.
Mosquito-proof emulsion the most as claimed in claim 6, it is characterised in that described composition C has with the mixing of described components D Body is: take a certain amount of VE or VE derivant, is soaked in a small amount of glycerol 2~5 days, is added thereto to ephedrine; A certain amount of lecithin, Poria extract and natural squalane being sequentially added in glycerol, soak 2~5 days, every day vibrates 3~6 times, each 5~10 minutes;By add ephedrine the glycerol mixture containing VE or VE derivant rapidly join to In glycerol mixture containing lecithin, Poria extract and natural squalane, add suitable quantity of water, vibrate 10~30 minutes, Temperature is 20~40 DEG C, obtains the mixture of described composition C and described components D.
Mosquito-proof emulsion the most as claimed in claim 7, it is characterised in that by prepared described composition A and described composition B The mixture of mixture and described composition C and described components D remix, add under pressure is 0.5~1.33kPa Heat, to 100~120 DEG C, after continuing 3~10 minutes, is cooled to 60~70 DEG C, mixed liquor is carried out filter and remove residue, then enters Horizontal high voltage steam sterilization, obtains the emulsion that mosquito control is bitten.
Mosquito-proof emulsion the most as claimed in claim 1, it is characterised in that also include Stigma Croci.
Mosquito-proof emulsion the most as claimed in claim 9, it is characterised in that take Stigma Croci described in 0.2~1g be soaked in 200~ In 600mL water, after soaking 20~40 minutes, heating infusion remains 60~200mL to water, takes upper liquid with mass ratio Add to the mixture of described composition A and composition B for 1:5~1:8.
CN201610452777.0A 2016-06-22 2016-06-22 Anti-mosquito lotion Pending CN105997660A (en)

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CN113142249A (en) * 2021-02-02 2021-07-23 无比滴(广东)药业有限公司 Electrothermal aromatherapy liquid and preparation method thereof
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