CN106214571A - A kind of Melia azedarach L. mosquito dispersing compositions and its preparation method and application - Google Patents
A kind of Melia azedarach L. mosquito dispersing compositions and its preparation method and application Download PDFInfo
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- CN106214571A CN106214571A CN201610763399.8A CN201610763399A CN106214571A CN 106214571 A CN106214571 A CN 106214571A CN 201610763399 A CN201610763399 A CN 201610763399A CN 106214571 A CN106214571 A CN 106214571A
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The present invention relates to mosquito formulation art, particularly relate to a kind of Melia azedarach L. mosquito dispersing compositions and its preparation method and application.Melia azedarach L. mosquito dispersing compositions of the present invention includes the component of following mass fraction: Melia azedarach L. 20 60 parts, Lignum Aquilariae Resinatum 20 50 parts, flower pears 20 50 parts, fragrant 1 30 parts of Radix Pandani Furcati leaf, Herba Eupatorii Odorati 1 30 parts, Herba Mimosae Pudicae 1 10 parts, Herba Taraxaci 1 10 parts, Borneolum Syntheticum 0.5 5 parts.By prescription compatibility, mosquito dispersing compositions of the present invention has the abnormal smells from the patient of uniqueness, can effectively remove mosquito, and to playing bag due to mosquito bite generations, the symptom such as itch has and good stop trace, antipruritic, reducing swelling and alleviating pain, antianaphylactic effect.The preparation method that the present invention provides, adopts and can effectively protect volatile ingredient therein not to be destroyed, and manufacturing process is simple, easily operates.The compositions prepared can be used for preparing the preparation of multiple mosquito dispersing.
Description
Technical field
The present invention relates to mosquito formulation art, particularly relate to a kind of Melia azedarach L. mosquito dispersing compositions and preparation method thereof and answer
With.
Background technology
Along with the arrival in summer, mosquito comes into play again, after biting, not only bring skin to itch, red and swollen etc. all not
Suitable sense, and easily infect disease, affect the orthobiosis of people.After mosquito bite, its saliva or venom invade skin, by
Containing multiple antigenic component in the saliva of mosquito or the leachate of poison gland, these antigens can be with antibody after entering human body skin
Produce atopic reaction and cause inflammation.Time serious, few patients local produces the severe reaction such as bulla, hemorrhagic necrosis, is the summer
Season dermatology common disease disease.Hainan tropical rainforest area, average temperature of the whole year more than 20 DEG C, mosquito activity time length, number
Measuring many, wide variety, mosquito dispersing preparation is one of standing article.And existing mosquito dispersing preparation, mostly contain chemical composition, hold
Easily to human body, the especially people of infant and sensitive body constitution works the mischief.
Margosa (Melia azedarach) is the well-known variety in Meliaceae plant, its bark, root bark, leaf, fruit, flower
All can be used as medicine, evident in efficacy.But Cortex Meliae, Folium Meliae and Fructus Toosendan all have toxicity in various degree, and Chang Peiwu makes clinically
With, all achieve preferable curative effect.
Summary of the invention
The present invention proposes a kind of Melia azedarach L. mosquito dispersing compositions and preparation method thereof and preparation, using Melia azedarach L. as main one-tenth
Point, by compatibility, have mosquito dispersing, anti-bite, antipruritic, effect of reducing swelling and alleviating pain.
The technical scheme is that and be achieved in that:
A kind of Melia azedarach L. mosquito dispersing compositions, including the component of following mass fraction: Melia azedarach L. 20-60 part, Lignum Aquilariae Resinatum 20-50
Part, flower pears 20-50 part, fragrant Radix Pandani Furcati leaf 1-30 part, Herba Eupatorii Odorati 1-30 part, Herba Mimosae Pudicae 1-10 part, Herba Taraxaci 1-10 part, Borneolum Syntheticum 0.5-
5 parts.
Further, described Melia azedarach L. mosquito dispersing compositions, including the component of following mass fraction: Melia azedarach L. 30-50 part, Rhizoma Atractylodis macrocephalae
Fragrant 30-40 part, flower pears 30-40 part, fragrant Radix Pandani Furcati leaf 10-20 part, Herba Eupatorii Odorati 10-20 part, Herba Mimosae Pudicae 2-8 part, Herba Taraxaci 2-8 part,
Borneolum Syntheticum 1-3 part.
Further, described Melia azedarach L. is Cortex Meliae or Folium Meliae.
The preparation method of a kind of Melia azedarach L. mosquito dispersing combination, comprises the following steps:
Weigh Melia azedarach L., Lignum Aquilariae Resinatum, Hua Li, fragrant Radix Pandani Furcati leaf, Herba Eupatorii Odorati, Herba Mimosae Pudicae, Herba Taraxaci by formula ratio, add ethanol and carry
Take 3 times, control temperature 10-40 DEG C during ethanol extraction, merge 3 extracting solution, be filtered to remove residue, be dried, add Borneolum Syntheticum,
Mixing, obtains Melia azedarach L. mosquito dispersing compositions of the present invention.
Further, described ethanol volumetric concentration is 70-85%；Described amount of alcohol added is medical material total amount 5-10 times, carries
The mode of taking is soak extraction or supersound extraction；The described method used that is dried is vacuum drying or lyophilization.
The application on preparation mosquito dispersing preparation of the above-described Melia azedarach L. mosquito dispersing compositions.
11. 1 kinds of Melia azedarach L. mosquito dispersing preparations, it is characterised in that: include the mosquito dispersing group described in any one of claim 1-6
Compound.
Further, above-mentioned mosquito dispersing preparation is solid or liquid.
A kind of mosquito dispersing preparation of liquid, its preparation method comprises the following steps:
Taking above-mentioned prepared Melia azedarach L. mosquito dispersing compositions, the ethanol adding composition quality 10-30 times dissolves, and is filtered to remove
Insoluble matter, sterilizing, to obtain final product.
The mosquito dispersing preparation of a kind of solid, it is characterised in that its preparation method comprises the following steps:
Take above-mentioned Melia azedarach L. mosquito dispersing compositions to pulverize, addition adjuvant, mix homogeneously, compressing, to obtain final product.
Beneficial effects of the present invention:
Melia azedarach L. mosquito dispersing compositions of the present invention, selects Melia azedarach L., Lignum Aquilariae Resinatum and flower pears conduct that torrid areas is common
Primary raw material, and with the addition of fragrant Radix Pandani Furcati leaf, Herba Eupatorii Odorati, Herba Mimosae Pudicae, Herba Taraxaci and Borneolum Syntheticum, by prescription compatibility, there is uniqueness
Abnormal smells from the patient, can effectively remove mosquito, to playing bag due to mosquito bite generation, the symptom such as itch have good only trace, antipruritic, disappear
Effect of swollen pain relieving.The preparation method that the present invention provides, uses the effective ingredient in ethanol extraction medical material, controls during extraction
In relatively low temperature, can effectively protect volatile ingredient therein not to be destroyed, manufacturing process is simple, easily operates.
Melia azedarach L. bitter in the mouth, cold in nature, there is parasite killing and treat the effect of tinea；Lignum Aquilariae Resinatum fragrance is quiet and beautiful, and persistently, and can have row
Gas, warming middle-JIAO, effect of relievining asthma；Effect that flower pears have circulation of qi promoting, invigorate blood circulation, has the curative effect of uniqueness to skin allergy.Fragrant Radix Pandani Furcati leaf
Having rice-pudding fragrance of uniqueness, the Squalene contained in leaf has infiltration, diffusion and bactericidal action, can strengthen cell viability and immunity
Power；Herba Eupatorii Odorati is micro-pungent, temperature, has dissipating blood stasis for subsidence of swelling, removing toxic substances, and effect of hemostasis all has relatively for treating swelling and pain by traumatic injury, sore swollen toxin etc.
Good curative effect.Herba Mimosae Pudicae have clearing away heat and promoting diuresis, ataralgesia, removing toxic substances, dissipating blood stasis, stop blooding, the effect such as convergence, for treating swelling and pain by traumatic injury,
Sore swollen toxins etc. all have preferable curative effect.Herba Taraxaci has eliminating stagnation, detumescence effect, accelerates blood circulation, promotes the disappearance of lump,
Its removing toxic substances, detumescence, antipruritic effect the most notable.Borneolum Syntheticum main component is dextro Borneolum Syntheticum, abnormal smells from the patient delicate fragrance, has certain mosquito dispersing
Effect.
Above medical material passes through prescription compatibility, interacts between the property of medicine, can effectively neutralize the toxicity of Melia azedarach L., eliminates Melia azedarach L.
The toxicity injury to human body.In prescription, Lignum Aquilariae Resinatum, fragrant Radix Pandani Furcati leaf have unique fragrance, adjust with the taste of other components in prescription
With coexist, form unique abnormal smells from the patient, it is possible to reach preferable mosquito-repelling effect.Simultaneously, it may have good removing toxic substances and promoting subsidence of swelling, only
Itch, prevent and treat effect of skin allergy.Additionally, due to the effective ingredient that Borneolum Syntheticum has in good volatility, beneficially prescription is waved
Being scattered in air, the mosquito-repelling effect of prescription Chinese crude drug is the most notable.And Borneolum Syntheticum is prone to percutaneous absorbtion；Effective ingredient in fragrant Radix Pandani Furcati
Also there is preferable osmosis, the absorption of other medical material in prescription is had good facilitation, it is possible to make in prescription
Removing toxic substances and promoting subsidence of swelling, antipruritic effect preferably play, reach the purpose of Quick itch stopping, detumescence.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the present invention is clearly and completely described, it is clear that
Described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based on the enforcement in the present invention
Example, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, broadly fall into
The scope of protection of the invention.
Embodiment 1
A kind of Melia azedarach L. mosquito dispersing compositions, including the component of following quality: Cortex Meliae 20g, Lignum Aquilariae Resinatum 20g, flower pears 20g,
Fragrant Radix Pandani Furcati leaf 1g, Herba Eupatorii Odorati 1g, Herba Mimosae Pudicae 1g, Herba Taraxaci 1g, Borneolum Syntheticum 0.5g.
The preparation method of a kind of Melia azedarach L. mosquito dispersing combination, comprises the following steps:
Weigh Cortex Meliae, Hua Li, Lignum Aquilariae Resinatum, fragrant Radix Pandani Furcati leaf, Herba Eupatorii Odorati, Herba Mimosae Pudicae, Herba Taraxaci by formula ratio, add volume
Concentration be 70% soak with ethanol extract 3 times, amount of alcohol added is medical material total amount 5 times；Temperature 10 is controlled during ethanol extraction
DEG C, merging 3 extracting solution, be filtered to remove residue, filter vacuum is dry, adds Borneolum Syntheticum, mixing, obtains of the present invention
Melia azedarach L. mosquito dispersing compositions.
Above-mentioned prepared compositions can add corresponding adjuvant, is used for preparing multiple mosquito dispersing preparation.
Embodiment 2
A kind of Melia azedarach L. mosquito dispersing compositions, including the component of following quality: Folium Meliae 60g, Lignum Aquilariae Resinatum 50g, flower pears 50g,
Fragrant Radix Pandani Furcati leaf 30g, Herba Eupatorii Odorati 30g, Herba Mimosae Pudicae 10g, Herba Taraxaci 10g, Borneolum Syntheticum 5g.
The preparation method of a kind of Melia azedarach L. mosquito dispersing combination, comprises the following steps:
Weigh Folium Meliae, Lignum Aquilariae Resinatum, Hua Li, fragrant Radix Pandani Furcati leaf, Herba Eupatorii Odorati, Herba Mimosae Pudicae, Herba Taraxaci by formula ratio, add volume
Concentration is the soak with ethanol/supersound extraction 3 times of 85%, and amount of alcohol added is medical material total amount 10 times；Control during ethanol extraction
Temperature 40 DEG C, merges 3 extracting solution, is filtered to remove residue, filtrate lyophilization, adds Borneolum Syntheticum, mixing, obtains of the present invention
Melia azedarach L. mosquito dispersing compositions.
Above-mentioned prepared compositions can add corresponding adjuvant, for preparing the several formulations of mosquito dispersing.
Embodiment 3
A kind of Melia azedarach L. mosquito dispersing compositions, including the component of following quality: Folium Meliae 40g, Lignum Aquilariae Resinatum 35g, flower pears 35g,
Fragrant Radix Pandani Furcati leaf 15g, Herba Eupatorii Odorati 15g, Herba Mimosae Pudicae 5g, Herba Taraxaci 5g, Borneolum Syntheticum 2g.
The preparation method of a kind of Melia azedarach L. mosquito dispersing combination, comprises the following steps:
Weigh Folium Meliae, Lignum Aquilariae Resinatum, Hua Li, fragrant Radix Pandani Furcati leaf, Herba Eupatorii Odorati, Herba Mimosae Pudicae, Herba Taraxaci by formula ratio, add volume
Concentration is the soak with ethanol/supersound extraction 3 times of 70-85%, and amount of alcohol added is medical material total amount 8 times；Control during ethanol extraction
Temperature processed 20 DEG C, merges 3 extracting solution, is filtered to remove residue, and filter vacuum is dried, and adds Borneolum Syntheticum, mixing, obtains institute of the present invention
The Melia azedarach L. mosquito dispersing compositions stated.
Above-mentioned prepared compositions can add corresponding adjuvant, is used for preparing multiple mosquito dispersing preparation.
Embodiment 4
A kind of Melia azedarach L. mosquito dispersing compositions, including the component of following quality: Cortex Meliae 30g, Lignum Aquilariae Resinatum 30g, flower pears 30g,
Fragrant Radix Pandani Furcati leaf 10g, Herba Eupatorii Odorati 10g, Herba Mimosae Pudicae 2g, Herba Taraxaci 2g, Borneolum Syntheticum 1g.
The preparation method of a kind of Melia azedarach L. mosquito dispersing combination, comprises the following steps:
Weigh Cortex Meliae, Lignum Aquilariae Resinatum, Hua Li, fragrant Radix Pandani Furcati leaf, Herba Eupatorii Odorati, Herba Mimosae Pudicae, Herba Taraxaci by formula ratio, add volume
Concentration is the ethanol ultrasonic extraction 3 times of 75%, and amount of alcohol added is medical material total amount 6 times；Temperature 30 is controlled during ethanol extraction
DEG C, merge 3 extracting solution, be filtered to remove residue, filtrate lyophilization, add Borneolum Syntheticum, mixing, obtain Melia azedarach L. of the present invention
Mosquito dispersing compositions.
Above-mentioned prepared compositions can add corresponding adjuvant, for preparing the several formulations of mosquito dispersing.
Embodiment 5
A kind of Melia azedarach L. mosquito dispersing compositions, including the component of following quality: Cortex Meliae 50g, Lignum Aquilariae Resinatum 40g, flower pears 40g,
Fragrant Radix Pandani Furcati leaf 20g, Herba Eupatorii Odorati 20g, Herba Mimosae Pudicae 8g, Herba Taraxaci 8g, Borneolum Syntheticum 3g.
The preparation method of a kind of Melia azedarach L. mosquito dispersing combination, comprises the following steps:
Weigh Cortex Meliae, Lignum Aquilariae Resinatum, Hua Li, fragrant Radix Pandani Furcati leaf, Herba Eupatorii Odorati, Herba Mimosae Pudicae, Herba Taraxaci by formula ratio, add volume
Concentration be 80% soak with ethanol extract 3 times, amount of alcohol added is medical material total amount 10 times；Temperature 10 is controlled during ethanol extraction
DEG C, merge 3 extracting solution, be filtered to remove residue, lyophilization, add Borneolum Syntheticum, mixing, obtain Melia azedarach L. anophelifuge of the present invention
Worm compositions.
Above-mentioned prepared compositions can add corresponding adjuvant, is used for preparing multiple mosquito dispersing preparation.
Embodiment 6
A kind of liquid mosquito expelling preparation, its preparation method comprises the following steps:
Taking above-mentioned prepared Melia azedarach L. mosquito dispersing compositions, the ethanol adding composition quality 10-30 times dissolves, and is filtered to remove
Insoluble matter, sterilizing, to obtain final product.
Liquid mosquito expelling worm preparation obtained by the present embodiment can make multiple dose of spray, externally applied liniment etc. as required
Type, is directly sprayed onto the surface of air or skin, medicated clothing etc., plays the effect of prevention mosquito bite.Can also sting mosquito
It is applied to affected part after stinging, plays effect antipruritic, that detoxify, subside a swelling.
Embodiment 7
The mosquito dispersing preparation of a kind of solid, it is characterised in that its preparation method comprises the following steps:
Taking above-mentioned Melia azedarach L. mosquito dispersing compositions to pulverize, add the adjuvant such as charcoal powder and starch, the addition of charcoal powder is
20-30 times of compositions gross mass, the addition of starch is 5-10 times of compositions gross mass；Mix homogeneously, adding water, it is viscous to make
Paste thing, compressing, it is dried, to obtain final product.
Solid mosquito dispersing preparation obtained by this enforcement, can be directly prepared into common mosquito incense, directly light use.Can also make
Become electric mat, the gas evaporated by anti-mosquito incense sheet, play the effect of mosquito dispersing.
Melia azedarach L. mosquito dispersing compositions application effect of the present invention
Take the mosquito dispersing compositions obtained by embodiment of the present invention 1-5 respectively, respectively according to the method for embodiment 6 or 7
Prepare mosquito repellent, randomly choose 30 people in different places, be allocated as 6 groups at random, often organize 5 people.Wherein 5 groups as experimental group,
The proportioning described in embodiment of the present invention 1-5 is used to produce different mosquito dispersing preparations respectively；6th group uses Liushen toilet water conduct
Matched group.Select the places such as the more waterside of mosquito, the woods, thick grass, open deck to try out, find to use the present invention made
Mosquito dispersing spray, mosquito incense or electric mat after, mosquito not close to, the situation of mosquito bite significantly reduces, or
It is completely eliminated.Suitable with conventional Liushen toilet water repelling effect, there is significant mosquito-repelling effect.
After the mosquito-repellent water using gained of the present invention is applied to the skin surface of mosquito bite, abnormal smells from the patient delicate fragrance, it is possible to produce
Unique cooling sensation, it is possible to quickly eliminate redness, itch, the symptom such as allergy, have significantly detumescence, antipruritic, anti-inflammation,
Removing toxic substances, anti-allergic effects.Especially to the anaphylaxis produced because of mosquito bite, mosquito dispersing preparation effect ten of the present invention
Clearly demarcated aobvious.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Within god and principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (10)
1. a Melia azedarach L. mosquito dispersing compositions, it is characterised in that include the component of following mass fraction: Melia azedarach L. 20-60 part, Rhizoma Atractylodis macrocephalae
Fragrant 20-50 part, flower pears 20-50 part, fragrant Radix Pandani Furcati leaf 1-30 part, Herba Eupatorii Odorati 1-30 part, Herba Mimosae Pudicae 1-10 part, Herba Taraxaci 1-10 part,
Borneolum Syntheticum 0.5-5 part.
2. a kind of Melia azedarach L. mosquito dispersing compositions as claimed in claim 1, it is characterised in that include the group of following mass fraction
Part: Melia azedarach L. 30-50 part, Lignum Aquilariae Resinatum 30-40 part, flower pears 30-40 part, fragrant Radix Pandani Furcati leaf 10-20 part, Herba Eupatorii Odorati 10-20 part, Herba Mimosae Pudicae
2-8 part, Herba Taraxaci 2-8 part, Borneolum Syntheticum 1-3 part.
3. Melia azedarach L. mosquito dispersing compositions as claimed in claim 1 a kind of, it is characterised in that: described Melia azedarach L. be Cortex Meliae or
Folium Meliae.
4. the preparation method combined such as the Melia azedarach L. mosquito dispersing of claims 1 or 2 gained, comprises the following steps:
Weigh Melia azedarach L., Lignum Aquilariae Resinatum, Hua Li, fragrant Radix Pandani Furcati leaf, Herba Eupatorii Odorati, Herba Mimosae Pudicae, Herba Taraxaci by formula ratio, add ethanol extraction 3
Secondary, control temperature 10-40 DEG C during ethanol extraction, merge 3 extracting solution, be filtered to remove residue, be dried, add Borneolum Syntheticum, mixed
Even, obtain Melia azedarach L. mosquito dispersing compositions of the present invention.
The preparation method of a kind of Melia azedarach L. mosquito dispersing compositions the most as claimed in claim 3, it is characterised in that: described ethanol body
Volume concentrations is 70-85%；Described amount of alcohol added is medical material total amount 5-10 times, and extracting mode is soak extraction or ultrasonic carries
Take；The described method used that is dried is vacuum drying or lyophilization.
6. the application on preparation mosquito dispersing preparation of the Melia azedarach L. mosquito dispersing compositions as described in any one of claim 1 to 6.
7. a Melia azedarach L. mosquito dispersing preparation, it is characterised in that: include the mosquito dispersing compositions described in any one of claim 1-6.
8. a kind of Melia azedarach L. mosquito dispersing preparation as claimed in claim 8, it is characterised in that: above-mentioned mosquito dispersing preparation is solid, liquid
Body.
9. the mosquito dispersing preparation of a liquid, it is characterised in that its preparation method comprises the following steps:
Taking the Melia azedarach L. mosquito dispersing compositions described in any one of claim 1-6, the ethanol adding composition quality 10-30 times is molten
Solve, be filtered to remove insoluble matter, sterilizing, to obtain final product.
10. the mosquito dispersing preparation of a solid, it is characterised in that its preparation method comprises the following steps:
Take the Melia azedarach L. mosquito dispersing compositions described in any one of claim 1-6 to pulverize, add charcoal powder and starch,
Mix homogeneously, adds water and makes thickness paste, compressing, is dried, to obtain final product.
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| CN109260072A (en) * | 2018-09-30 | 2019-01-25 | 湖州稻草娃生物科技有限公司 | A kind of mosquito repellent liquid composition |
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| CN106214571B (en) | 2020-06-02 |
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