CN111632006A - Mosquito-repelling spray and preparation method thereof - Google Patents
Mosquito-repelling spray and preparation method thereof Download PDFInfo
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- CN111632006A CN111632006A CN202010546925.1A CN202010546925A CN111632006A CN 111632006 A CN111632006 A CN 111632006A CN 202010546925 A CN202010546925 A CN 202010546925A CN 111632006 A CN111632006 A CN 111632006A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention relates to the field of daily chemical articles, and particularly provides a mosquito-repellent spray and a preparation method thereof. The first aspect of the invention provides a mosquito-repellent spray, which at least comprises, by weight, 10-22 parts of a humectant, 0.7-2.1 parts of a plant component, 0.6-1.5 parts of a thickener, 0.1-0.15 part of a preservative and 80-90 parts of water; the mass ratio of the plant components to the thickening agent is 1: (0.3-1.3).
Description
Technical Field
The invention relates to the field of daily chemical articles, and particularly provides a mosquito-repellent spray and a preparation method thereof.
Background
The presence of mosquitoes not only affects the work and sleep of humans, but also is a vector for the transmission of various diseases, and more than 60 diseases have been confirmed to be transmitted by mosquitoes. The mosquito repelling technology is widely applied in the field of cosmetics in China, and the traditional cosmetics with the mosquito repelling effect are mainly added with chemically synthesized repellents such as DEET (DEET), mosquito repelling oil (DMP) or citronellal and the like, and are smeared on the skin to form a protective film so that mosquitoes do not dare to approach. However, such chemical-added repellents may cause skin irritation and irritation.
Therefore, the mosquito repellent using plant essential oil as the main mosquito repellent component is gradually paid attention to due to the advantages of safety, no toxicity, environmental protection, small stimulation to human body and the like. However, many mosquito repellents using plant essential oil as a main component have short action time and poor comfort in use, and in addition, unreasonable plant compatibility also causes insufficient action of effective components in plants.
Disclosure of Invention
In order to solve the technical problems, the invention provides a mosquito-repellent spray in a first aspect, which comprises at least 10-22 parts by weight of humectant, 0.7-2.1 parts by weight of plant components, 0.6-1.5 parts by weight of thickener, 0.1-0.15 part by weight of preservative and 80-90 parts by weight of water; the mass ratio of the plant components to the thickening agent is 1: (0.3-1.3).
As a preferable technical scheme of the invention, the humectant is selected from one or a combination of more of 1, 2-hexanediol, ethanol, propylene glycol, sorbitol, butanediol, caprylyl glycol, methyl propylene glycol, dipropylene glycol, glycerol, diglycerol, glycerol polyether, pentanediol, isoprene glycol, polyethylene glycol, trehalose, sodium hyaluronate and sodium polyglutamate.
As a preferred embodiment of the present invention, the plant component comprises a first plant component and a second plant component; the first plant component is one or more of rhizoma acori graminei extract, pogostemon cablin extract, folium artemisiae argyi extract, rhizoma atractylodis extract, lemon extract, camphor tree leaf extract and clove extract; the second plant component comprises borneol and mint.
As a preferable technical solution of the present invention, the mass ratio of the first plant component to the second plant component is 1: (0.3-0.5).
As a preferable technical scheme of the invention, the mass ratio of the borneol to the mint is 1: (0.8 to 1.2).
As a preferable technical scheme of the invention, the thickening agent is one or a combination of more of hydrogenated castor oil, polysorbate-80, polyglycerol-3 distearate, polyglycerol-10 myristate, potassium lauryl phosphate, laureth-4 and PEG-6 caprylic/capric glyceride.
As a preferable technical scheme of the invention, the mass ratio of the hydrogenated castor oil to the polysorbate-80 to the PEG-6 caprylic/capric glycerides is 1: 1: (0.9-1.3).
As a preferable technical scheme of the invention, the preservative is selected from one or a combination of a plurality of methyl hydroxybenzoate, phenoxyethanol, methylisothiazolinone, phenyl salicylate, methyl p-hydroxybenzoate, bis (hydroxymethyl) imidazolidinyl urea and iodopropynyl alcohol butyl carbamate.
In a preferred embodiment of the present invention, the mass ratio of methylparaben to bis (hydroxymethyl) imidazolidinyl urea is 1: (0.8 to 1).
The second aspect of the invention provides a preparation method of the mosquito-repellent spray, which at least comprises the following steps: the components are mixed evenly to obtain the product.
Has the advantages that: the invention provides a mosquito-repellent spray, which selects various plant essences, has scientific compatibility of all components, supplements each other, has definite component efficacy, high safety, clear texture, mildness, no irritation, moistening and skin affinity, transparency, fineness and can effectively prevent mosquitoes and insects and resist external irritation; has high stability, is in the form of spray, is convenient to use and carry, and has the advantages of quick response, lasting effect, convenient use and wide application range.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the number clearly indicates the singular.
In order to solve the technical problems, the invention provides a mosquito-repellent spray in a first aspect, which comprises at least 10-22 parts by weight of humectant, 0.7-2.1 parts by weight of plant components, 0.6-1.5 parts by weight of thickener, 0.1-0.15 part by weight of preservative and 80-90 parts by weight of water; the mass ratio of the plant components to the thickening agent is 1: (0.3-1.3).
In a preferred embodiment, the preparation raw materials at least comprise 16 parts of humectant, 1.3 parts of plant component, 1 part of thickener, 0.12 part of preservative and 85 parts of water in parts by weight.
<Moisture-retaining agent>
The humectant is selected from one or a combination of more of 1, 2-hexanediol, ethanol, propylene glycol, sorbitol, butanediol, caprylyl glycol, methyl propylene glycol, dipropylene glycol, glycerol, diglycerol, glyceryl polyether, pentanediol, isoprene glycol, polyethylene glycol, trehalose, sodium hyaluronate and sodium polyglutamate.
In a preferred embodiment, the humectant comprises 1, 2-hexanediol, glycerin, ethanol, and propylene glycol.
In a more preferred embodiment, the humectant includes 0.2 to 0.5 parts by weight of 1, 2-hexanediol, 0.2 to 0.5 parts by weight of glycerin, 10 to 20 parts by weight of ethanol, and 0.2 to 0.3 parts by weight of propylene glycol.
In a more preferred embodiment, the humectant comprises 0.3 parts by weight of 1, 2-hexanediol, 0.3 parts by weight of glycerin, 15 parts by weight of ethanol, and 0.2 parts by weight of propylene glycol.
<Plant components>
The plant component of the present invention includes a first plant component and a second plant component.
In one embodiment, the mass ratio of the first plant component to the second plant component is 1: (0.3 to 0.5); preferably, the mass ratio of the first plant component to the second plant component is 1: 0.4.
a first plant component
The first plant component is selected from one or a combination of more of acorus gramineus soland extract, pogostemon cablin extract, folium artemisiae argyi extract, rhizoma atractylodis extract, lemon extract, camphor tree leaf extract and clove extract.
In a preferred embodiment, the first plant component comprises Acorus gramineus solander extract, Pogostemon cablin extract, Artemisia argyi extract, Atractylodes lancea rhizome extract, and Citrus limon extract.
In a preferred embodiment, the first plant component comprises 0.1-0.3 parts by weight of grassleaf sweelflag rhizome extract, 0.1-0.3 parts by weight of patchouli extract, 0.1-0.3 parts by weight of argyi leaf extract, 0.1-0.3 parts by weight of atractylodes rhizome extract and 0.1-0.3 parts by weight of lemon extract.
In a more preferred embodiment, the first plant component comprises 0.2 parts by weight of grassleaf sweelflag rhizome extract, 0.2 parts by weight of patchouli extract, 0.2 parts by weight of argyi leaf extract, 0.2 parts by weight of atractylodes rhizome extract, 0.2 parts by weight of lemon extract.
Acorus gramineus solander extract
The rhizoma acori graminei extract can play the roles of tranquilizing mind and relaxing the mind and body of a person and the like, gives the feeling of fragrance, resuscitation and relaxation to the person, and is beneficial to the health of the mind, body and brain. The active substance asarone has the effects of inducing resuscitation, restoring consciousness, sterilizing, diminishing inflammation, activating collaterals and channels and the like, so the asarone is often applied to functional perfume besides the medicine. Based on the selective elimination effect of the calamus extract on oxygen-containing free radicals, the calamus extract can be matched with other antioxidants to be used in cosmetics for resisting oxidation and ageing, whitening and resisting inflammation. The increase of the activity of the grass-leaved sweetflag extract on the cathepsin D shows the promotion of the metabolism function of the dermis.
Pogostemon cablin extract
The patchouli extract has the capabilities of resisting inflammation and sterilizing, can kill fungi and can promote cell regeneration; can enhance the digestive function of the gastrointestinal tract, promote the secretion of gastric juice and enhance the digestive ability of the intestines and stomach; can also revivify people and play a role in refreshing mind and restoring consciousness.
Folium Artemisiae Argyi extract
The folium artemisiae argyi extract contains various natural medicinal components, can enhance the anti-allergic capability of a human body after the human body absorbs the medicinal components, can reduce the occurrence of various allergic diseases, and has a certain treatment effect on common skin diseases such as allergic dermatitis, eczema, mange and the like of human beings. The antibacterial and antiviral effects are also important effects of the folium artemisiae argyi extract, and most of medicinal components in the folium artemisiae argyi are reserved in the folium artemisiae argyi extract, so that the folium artemisiae argyi extract can not only kill various germs in a human body, but also inhibit viruses from breeding in the human body.
Rhizoma Atractylodis extract
The rhizoma atractylodis extract contains volatile oil, wherein the oil mainly contains atractylodin, beta-eucalyptol, atractyl, hydroxyl atractylone and the like, and is warm in nature, pungent and bitter in taste. Has effects in eliminating dampness, invigorating spleen, expelling pathogenic wind, dispelling cold, and improving eyesight. Can be used for treating abdominal distention, diarrhea, edema, tinea pedis, arthralgia due to wind-cold evil, and night blindness.
Lemon extract
The lemon extract is rich in vitamin C, saccharides, calcium, phosphorus, iron, vitamin B1, vitamin B2, nicotinic acid, quinic acid, citric acid, malic acid, hesperidin, naringin, coumarins, high-content potassium elements, low-content sodium elements and the like, and has the effects of promoting the production of body fluid, quenching thirst, dispelling summer heat and preventing miscarriage. Dry mouth and sore throat, gastric distention, hypertension, myocardial infarction and poor appetite.
The grass-leaved sweetflag extract, patchouli extract, artemisia leaf extract, atractylodes rhizome extract and lemon extract according to the present invention can be obtained by commercially available methods, including but not limited to those purchased from Zheng Yilaien Biotech limited.
A second plant component
The second plant component of the present invention comprises borneol and mint.
In a preferred embodiment, the mass ratio of borneol to mint is 1: (0.8 to 1.2); more preferably, the mass ratio of the borneol to the mint is 1: 1.
borneol (borneol)
The borneol, named as borneol, orange slice, blumea balsamifera, borneol, tomatillo castanopsis, tomatillo fortunei, borneol, plum ice and the like is prepared by steam distillation and recrystallization of stems and leaves of blumea balsamifera of Compositae or branches and leaves of camphor of Lauraceae. Borneol is pungent, bitter and slightly cold in flavor; heart, liver and lung meridians entered; the product has effects of inducing resuscitation, refreshing mind, clearing heat, removing toxic substance, improving eyesight, and removing nebula, and can be used for treating fever, hyperpyrexia, coma, apoplexy, phlegm syncope, convulsion, summer-heat dampness covering resuscitation, pharyngitis, deafness, aphtha, swelling of teeth, skin ulcer, carbuncle, malnutritional hemorrhoid, conjunctival congestion, swelling and pain, nebula, and eye covering.
Mint
The mint, named 'Yindancao' in the invention is a labiate plant, mainly contains volatile oil, flavonoid, anthraquinone, organic acid, amino acid and the like, and has pharmacological effects of resisting inflammation, easing pain, resisting virus, resisting oxidation, resisting fertility, promoting transdermal absorption and the like.
The borneol and the mint of the invention can be obtained by commercial purchase, including but not limited to purchase from Zheng Yilaien Biotechnology GmbH.
<Thickening agent>
The thickening agent is selected from one or a combination of more of hydrogenated castor oil, polysorbate-80, polyglycerol-3 distearate, polyglycerol-10 myristate, potassium lauryl phosphate, laureth-4 and PEG-6 caprylic/capric glyceride.
In a preferred embodiment, the thickening agent comprises hydrogenated castor oil, polysorbate-80, and PEG-6 caprylic/capric glycerides.
In a more preferred embodiment, the mass ratio of hydrogenated castor oil, polysorbate-80 and PEG-6 caprylic/capric glycerides is 1: 1: (0.9 to 1.3); more preferably, the mass ratio of the hydrogenated castor oil, the polysorbate-80 and the PEG-6 caprylic/capric glycerides is 1: 1: 1.1.
according to the invention, the plant components added into the system are compounded to bring better mosquito repellent and cooling effects, but the prepared product is easy to generate layering phenomenon, and when the thickening agent comprising hydrogenated castor oil, polysorbate-80 and PEG-6 caprylic/capric glycerides is added into the system, the mass ratio of the plant components to the thickening agent is regulated to be 1: (0.3-1.3), not only solved above-mentioned problem, make this product have the effect of delaying release refrigerant moreover, can keep cool and cool feeling in long-time, through reducing the permeation rate, can reach the effect of diminishing inflammation and not irritating skin, avoided producing the influence of irritability to skin, improved the comfort of use, still bring more lasting mosquito repellent effect in addition.
<Preservative>
The preservative is selected from one or a combination of methyl hydroxybenzoate, phenoxyethanol, methylisothiazolinone, phenyl salicylate, methyl p-hydroxybenzoate, bis (hydroxymethyl) imidazolidinyl urea and iodopropynyl alcohol butyl carbamate.
In a preferred embodiment, the preservative comprises methylparaben and bis (hydroxymethyl) imidazolidinyl urea.
In a more preferred embodiment, the mass ratio of methylparaben to bis (hydroxymethyl) imidazolidinyl urea is 1: (0.8 to 1); more preferably, the mass ratio of the methyl hydroxybenzoate to the bis (hydroxymethyl) imidazolidinyl urea is 1: 0.9.
the second aspect of the invention provides a preparation method of the mosquito-repellent spray, which at least comprises the following steps: the components are mixed evenly to obtain the product.
In a preferred embodiment, the preparation method of the mosquito-repellent spray at least comprises the following steps: mixing the thickening agent, the humectant, the preservative and water, adding the plant components, stirring and mixing uniformly, then pouring the mixture into a vacuum stirring tank, vacuumizing and stirring for 9-12 min, filling and packaging to obtain the plant component.
The third aspect of the invention provides a using method of mosquito-repellent spray, which specifically comprises the following steps: spraying a proper amount of the mosquito-repellent spray at a distance of 10-20 cm away from the skin, and then uniformly smearing the mosquito-repellent spray by hands. When applied to the face, the face-protecting mask is firstly sprayed on the palm of the hand and then tapped on the face.
The amount of the spray is not limited, depending on the requirements.
Examples
In order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention. In addition, the starting materials used are all commercially available, unless otherwise specified.
Example 1
The embodiment 1 of the invention provides mosquito-repellent spray which comprises, by weight, 16 parts of a humectant, 1.3 parts of a plant component, 1 part of a thickener, 0.12 part of a preservative and 85 parts of water.
The humectant comprises 0.3 part of 1, 2-hexanediol, 0.3 part of glycerol, 15 parts of ethanol and 0.2 part of propylene glycol in parts by weight.
The plant component comprises a first plant component and a second plant component; the mass ratio of the first plant component to the second plant component is 1: 0.4; the first plant component comprises 0.2 part of rhizoma acori graminei extract, 0.2 part of pogostemon cablin extract, 0.2 part of folium artemisiae argyi extract, 0.2 part of rhizoma atractylodis extract and 0.2 part of lemon extract in parts by weight; the second plant component comprises borneol and mint; the mass ratio of the borneol to the mint is 1: 1.
the thickening agent comprises hydrogenated castor oil, polysorbate-80 and PEG-6 caprylic/capric glycerides; the mass ratio of the hydrogenated castor oil to the polysorbate-80 to the PEG-6 caprylic/capric glycerides is 1: 1: 1.1.
the preservative comprises methylparaben and bis (hydroxymethyl) imidazolidinyl urea; the mass ratio of the methyl hydroxybenzoate to the bis (hydroxymethyl) imidazolidinyl urea is 1: 0.9.
the rhizoma Acori Graminei extract, herba Agastaches extract, folium Artemisiae Argyi extract, rhizoma Atractylodis extract, fructus Citri Limoniae extract, Borneolum Syntheticum, and herba Menthae are purchased from Zhenlien biotechnology, Inc. of Zhengzhou province; the hydrogenated castor oil and polysorbate-80 are purchased from Shandong Yousio Hua engineering, Inc.; the PEG-6 caprylic/capric glycerides were purchased from Shandong Hao Shunji chemical Co., Ltd.
The preparation method of the mosquito-repellent spray comprises the following steps: mixing thickener, humectant, antiseptic and water, adding the plant components, stirring, mixing, pouring into a vacuum stirring tank, vacuumizing, stirring for 10min, packaging, and packaging.
Comparative example 1
Comparative example 1 of the present invention provides a mosquito repellent spray, which is similar to example 1 in the specific embodiment, except that the plant component is 0.8 parts by weight and the thickener is 0.5 parts by weight.
Comparative example 2
Comparative example 2 of the present invention provides a mosquito repellent spray, which is similar to example 1 in the embodiment except that hydrogenated castor oil is not used.
Comparative example 3
Comparative example 3 of the present invention provides a mosquito repellent spray, which is similar to example 1, except that polysorbate-80 is not included.
Comparative example 4
Comparative example 4 of the present invention provides a mosquito repellent spray, the specific embodiment of which is the same as example 1, except that there is no PEG-6 caprylic/capric glycerides.
Comparative example 5
Comparative example 5 of the present invention provides a mosquito repellent spray, which is the same as example 1 in the specific embodiment, except that the mass ratio of hydrogenated castor oil, polysorbate-80, and PEG-6 caprylic/capric glycerides is 1: 1: 2.
performance testing
1. Safety property testing
The mosquito repellent spray prepared in example 1 was subjected to physicochemical and microbiological tests according to technical safety standards for cosmetics (2015 edition), and the test results were as follows:
TABLE 1
As can be seen from the above table, the detection result meets the requirements of the enterprise logo Q/ELAN 24-2020.
2. Stability test
The mosquito-repellent spray prepared in the embodiment 1 and the comparative examples 1-5 is placed at room temperature for a week, whether layering occurs or not is observed, 100 parallel samples are respectively arranged in each embodiment, and the layering probability, namely the percentage of the number of the layered essence liquid to the total testing number, is recorded.
3. Test of use effect
60 volunteers, 50 men and 50 women, aged 20-45 years, were divided into 6 groups, and each group tried the mosquito repellent spray prepared in one example. The specific test steps are that one arm of a tested person sprays mosquito repellent spray, the other arm does not spray, the tested person sits in a green belt of the same cell for 20 minutes statically, the mosquito repellent effect is observed, and the average number of bites of the tested person by mosquitoes is recorded.
TABLE 2
The test results show that the components of the mosquito-repellent incense provided by the invention are scientific in compatibility and supplement each other, the efficacy of the components is clear, the safety is high, the texture is clear, the skin is mild and non-irritant when the mosquito-repellent incense is used, the skin is moistened and compatible, the skin is bright and fine, the mosquito-repellent incense can effectively prevent mosquitoes and insects, external irritation is resisted, and meanwhile, the stability is good.
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (10)
1. The mosquito-repellent spray is characterized by comprising, by weight, at least 10-22 parts of a humectant, 0.7-2.1 parts of a plant component, 0.6-1.5 parts of a thickener, 0.1-0.15 part of a preservative and 80-90 parts of water; the mass ratio of the plant components to the thickening agent is 1: (0.3-1.3).
2. The mosquito-repellent spray according to claim 1, wherein the humectant is selected from one or a combination of more of 1, 2-hexanediol, ethanol, propylene glycol, sorbitol, butylene glycol, caprylyl glycol, methyl propylene glycol, dipropylene glycol, glycerin, diglycerin, glyceryl polyether, pentanediol, isoprene glycol, polyethylene glycol, trehalose, sodium hyaluronate, and sodium polyglutamate.
3. A mosquito repellent spray according to claim 1 wherein the plant components comprise a first plant component and a second plant component; the first plant component is one or more of rhizoma acori graminei extract, pogostemon cablin extract, folium artemisiae argyi extract, rhizoma atractylodis extract, lemon extract, camphor tree leaf extract and clove extract; the second plant component comprises borneol and mint.
4. The mosquito repellent spray according to claim 3, wherein the mass ratio of the first plant component to the second plant component is 1: (0.3-0.5).
5. The mosquito-repellent spray according to claim 3, wherein the mass ratio of the borneol to the mint is 1: (0.8 to 1.2).
6. A mosquito repellent spray according to claim 1, wherein the thickener is selected from one or more of hydrogenated castor oil, polysorbate-80, polyglyceryl-3 distearate, polyglyceryl-10 myristate, potassium lauryl phosphate, laureth-4, PEG-6 caprylic/capric glycerides.
7. The mosquito repellent spray according to claim 6, wherein the mass ratio of the hydrogenated castor oil to the polysorbate-80 to the PEG-6 caprylic/capric glycerides is 1: 1: (0.9-1.3).
8. A mosquito repellent spray according to claim 1, wherein the preservative is selected from one or a combination of methyl paraben, phenoxyethanol, methylisothiazolinone, phenyl salicylate, methyl paraben, bis (hydroxymethyl) imidazolidinyl urea, and iodopropynyl butylcarbamate.
9. A mosquito repellent spray according to claim 8, wherein the mass ratio of methyl hydroxybenzoate to bis (hydroxymethyl) imidazolidinyl urea is 1: (0.8 to 1).
10. A method of preparing a mosquito repellent spray according to any one of claims 1 to 9, comprising at least the steps of: the components are mixed evenly to obtain the product.
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| CN202010546925.1A CN111632006A (en) | 2020-06-16 | 2020-06-16 | Mosquito-repelling spray and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115282109A (en) * | 2021-09-15 | 2022-11-04 | 上海江笙生物科技有限公司 | Herbal skin-friendly and mosquito-repellent spray and preparation method thereof |
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2020
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115282109A (en) * | 2021-09-15 | 2022-11-04 | 上海江笙生物科技有限公司 | Herbal skin-friendly and mosquito-repellent spray and preparation method thereof |
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