CN115282109A - Herbal skin-friendly and mosquito-repellent spray and preparation method thereof - Google Patents
Herbal skin-friendly and mosquito-repellent spray and preparation method thereof Download PDFInfo
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- CN115282109A CN115282109A CN202111084331.4A CN202111084331A CN115282109A CN 115282109 A CN115282109 A CN 115282109A CN 202111084331 A CN202111084331 A CN 202111084331A CN 115282109 A CN115282109 A CN 115282109A
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- 239000007921 spray Substances 0.000 title claims abstract description 54
- 239000000077 insect repellent Substances 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000000284 extract Substances 0.000 claims abstract description 77
- 241000196324 Embryophyta Species 0.000 claims abstract description 30
- 239000002253 acid Substances 0.000 claims abstract description 21
- 239000003755 preservative agent Substances 0.000 claims abstract description 20
- 230000002335 preservative effect Effects 0.000 claims abstract description 20
- 239000002562 thickening agent Substances 0.000 claims abstract description 17
- 150000001875 compounds Chemical class 0.000 claims abstract description 16
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000008367 deionised water Substances 0.000 claims abstract description 9
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 71
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 41
- 239000000203 mixture Substances 0.000 claims description 30
- 229960005150 glycerol Drugs 0.000 claims description 23
- 239000000419 plant extract Substances 0.000 claims description 23
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 23
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 21
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 20
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 20
- 239000000811 xylitol Substances 0.000 claims description 20
- 235000010447 xylitol Nutrition 0.000 claims description 20
- 229960002675 xylitol Drugs 0.000 claims description 20
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 claims description 19
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 19
- 229960004889 salicylic acid Drugs 0.000 claims description 19
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 18
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 16
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 16
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 16
- 239000001814 pectin Substances 0.000 claims description 13
- 235000010987 pectin Nutrition 0.000 claims description 13
- 229920001277 pectin Polymers 0.000 claims description 13
- -1 polyol compound Chemical class 0.000 claims description 6
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims description 3
- 240000006891 Artemisia vulgaris Species 0.000 claims description 3
- 241000132012 Atractylodes Species 0.000 claims description 3
- 229920005862 polyol Polymers 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 229960004365 benzoic acid Drugs 0.000 claims description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
- 229940040102 levulinic acid Drugs 0.000 claims description 2
- 235000010199 sorbic acid Nutrition 0.000 claims description 2
- 239000004334 sorbic acid Substances 0.000 claims description 2
- 229940075582 sorbic acid Drugs 0.000 claims description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims 4
- 244000042238 Eurycoma Species 0.000 claims 2
- 241000208181 Pelargonium Species 0.000 claims 2
- 229940051250 hexylene glycol Drugs 0.000 claims 2
- 229940058015 1,3-butylene glycol Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001442 anti-mosquito Effects 0.000 abstract description 15
- 241000208818 Helianthus Species 0.000 abstract description 11
- 235000003222 Helianthus annuus Nutrition 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 11
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 230000003020 moisturizing effect Effects 0.000 abstract description 3
- 244000153234 Hibiscus abelmoschus Species 0.000 abstract 2
- 235000011187 glycerol Nutrition 0.000 description 21
- 241000402754 Erythranthe moschata Species 0.000 description 16
- 230000000052 comparative effect Effects 0.000 description 12
- 241000255925 Diptera Species 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 230000001846 repelling effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 240000000982 Malva neglecta Species 0.000 description 3
- 235000000060 Malva neglecta Nutrition 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 244000290333 Vanilla fragrans Species 0.000 description 3
- 235000009499 Vanilla fragrans Nutrition 0.000 description 3
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 3
- 238000002242 deionisation method Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000002035 prolonged effect Effects 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
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- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 241000600332 Anemone vitifolia Species 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 229940116229 borneol Drugs 0.000 description 2
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 2
- 230000032798 delamination Effects 0.000 description 2
- 230000003467 diminishing effect Effects 0.000 description 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 2
- 230000037336 dry skin Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical group COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 239000002344 surface layer Substances 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 1
- 206010003399 Arthropod bite Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000008952 bacterial invasion Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- ICJBPZBRDLONIF-UHFFFAOYSA-N hexane-1,1,1,2,2,3-hexol Chemical compound CCCC(O)C(O)(O)C(O)(O)O ICJBPZBRDLONIF-UHFFFAOYSA-N 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 229940119463 sunflower seed extract Drugs 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Plant Pathology (AREA)
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Abstract
The invention relates to the field of A61K daily chemical products, and particularly provides herbal skin-friendly mosquito-proof spray and a preparation method thereof. The invention provides a herbal skin-friendly mosquito-repellent spray, which is prepared from plant components, C2-C10 polyalcohol compounds, a plant thickening agent, an acid preservative and deionized water. Compared with the prior art, the moschus extract, the folium artemisiae argyi extract, the rhizoma atractylodis extract and the sunflower extract are added, and active components of the moschus extract, the folium artemisiae argyi extract, the rhizoma atractylodis extract and the sunflower extract are subjected to synergistic action, so that the prepared herbal skin-friendly anti-mosquito spray obviously improves the stability, the antibacterial performance and the moisturizing performance of a system while ensuring the anti-mosquito effect.
Description
Technical Field
The invention relates to the field of A61K daily chemical products, and particularly provides herbal skin-friendly mosquito-proof spray and a preparation method thereof.
Background
With the continuous rise of global temperature, people are more easily bitten by mosquitoes in hot summer, the skin is itchy, red and swollen, even painful due to the mosquito bite, the mosquitoes can carry various germs, and the germs are transmitted to the human body through blood circulation by biting the skin of the human body, so the life health of the human body is seriously harmed. But the mosquito repellent spray in the prior art has the problems of poor stability and poor use touch feeling.
Chinese patent with patent publication No. CN110934777A discloses a natural herbal spray with itching and mosquito repelling effects, which achieves the effect of repelling mosquitoes by adding various natural extracts and compounding the natural extracts, but the active ingredients among the natural extracts in the scheme can react to generate a layering phenomenon, so that the problems of poor system stability and short mosquito repelling effect time exist.
Chinese invention kilometer with patent publication No. CN111632006A discloses a mosquito-repellent spray and a preparation method thereof, borneol is added in the mosquito-repellent spray, and the borneol can cause allergy to people with sensitive skin and red and hot skin, so that the people using the mosquito-repellent spray are limited.
Disclosure of Invention
In order to solve the problems, the invention provides an herbal skin-friendly mosquito-repellent spray which comprises the following raw materials in parts by weight: 0.5 to 2 parts of plant component, 15 to 20 parts of C2 to C10 polyhydric alcohol compound, 0.5 to 1 part of plant thickening agent, 0.1 to 0.3 part of acid preservative and 85 to 95 parts of deionized water.
As a preferable technical scheme of the invention, the plant component is a mixture of plant extract and mint.
As a preferable technical scheme, the mass ratio of the plant extract to the mint is 1: (0.2-0.8).
As a preferred technical solution of the present invention, the plant extract is a mixture of a musk extract, a mugwort leaf extract, a atractylodes rhizome extract and a sunflower seed extract.
As a more preferable technical scheme of the invention, the mass ratio of the musk guang extract to the folium artemisiae argyi extract to the rhizoma atractylodis extract to the sunflower extract is (0.2-0.6): (0.1-0.3): (0.2-0.4): (0.5-1.5).
As the most preferable technical scheme in the first invention, the mass ratio of the musk guang extract to the folium artemisiae argyi extract to the rhizoma atractylodis extract to the sunflower extract is 0.5:0.2:0.3:1.
as a preferable technical scheme of the invention, the C2-C10 polyalcohol compounds are at least one of glycerol, 1, 3-butanediol, hexanehexol, xylitol and hexanediol.
As a more preferable technical scheme of the invention, the C2-C10 polyalcohol compounds are a mixture of glycerol, xylitol and 1,2 hexanediol.
As a most preferable technical scheme of the invention, the mass ratio of the glycerol to the xylitol to the 1, 2-hexanediol is 0.5: (1-2): (1-2).
The applicant finds that when the C2-C10 polyalcohol compounds added into the system are only glycerol, although the moisturizing performance of the system can be obviously enhanced, the glycerol has sticky feeling when being sprayed on the surface layer of the skin, and if the glycerol stays for a long time, the water-oil balance on the surface of the skin is influenced, and the phenomenon of acne growing occurs; in northern areas with low humidity, glycerin absorbs moisture from the skin, resulting in dry skin. In order to solve the above problems, the applicant found that when a certain concentration of a combination of glycerin, xylitol and 1, 2-hexanediol is added to a system, and the mass ratio of glycerin, xylitol and 1, 2-hexanediol is 0.5:1.5:1.5, the effect that reaches through the synergistic effect between them is the best, can effectively avoid dry skin, especially can alleviate and appear the poor problem of spraying moisturizing performance easily in the region that humidity is less than 30% in the north, can show the viscosity that reduces the system simultaneously, improves and uses the sense of touch, strengthens the stability of system, makes things convenient for liquid to spout from the spray bottle bottleneck.
In a preferred embodiment of the present invention, the plant thickener is at least one of gum arabic, pectin, and carrageenan.
In order to improve the moisture absorption and moisture retention effects of the system, interact with other components in the system, improve the stability of the system and prolong the mosquito repellent effect of the herbal skin-friendly mosquito repellent spray on the premise of ensuring that the herbal skin-friendly mosquito repellent spray has an excellent mosquito repellent effect, as a preferred technical scheme, the plant thickening agent is pectin.
The applicant finds that when pectin is selected as a thickening agent in a system, on the premise of ensuring that the herbal skin-friendly anti-mosquito spray has excellent effects of diminishing swelling and relieving pain, polar groups in the pectin interact with active components in the musk guang extract to form a layer of colloidal matrix on the surface of skin, so that skin moisture is locked, the moisture on the surface layer of the skin is diffused to the horny layer, the water and oil of the skin are promoted to be balanced, the phenomenon of stuffiness is avoided, meanwhile, bacterial invasion is prevented, and the antibacterial performance of the system is enhanced.
In a preferred embodiment of the present invention, the acid preservative is at least one of benzoic acid, levulinic acid, sorbic acid, salicylic acid, and octanoyl hydroxamic acid.
As a preferred technical scheme of the invention, the acid preservative is a mixture of salicylic acid and caprylyl hydroxamic acid.
As a more preferable technical scheme of the invention, the mass ratio of the salicylic acid to the octanoyl hydroxamic acid is (0.2-1.2): 1.
the applicant has surprisingly found that when a mass ratio of 0.5: when 1 salicylic acid and octanoyl hydroxamic acid mixture are used as the preservative, on the one hand, the pH value of the system can be regulated and controlled, and on the other hand, the mixture can interact with other components in the system, so that the stability of the system is improved, and the action time of herbal skin-friendly mosquito-proof spraying is prolonged. The applicant conjectures that polar groups in the salicylic acid and the octanoyl hydroxamic acid interact with active ingredients in the plant extract, so that the compatibility of the plant extract in a system is obviously improved, the mosquito repellent ingredients in the plant extract can fully play a role, the stability of the system is improved, and the acting time of the herbal skin-friendly mosquito repellent spray is prolonged.
As a preferred technical scheme of the invention, the mass ratio of the acid preservative to the plant components is (1.. 5-2.5): (1.0-2).
The invention provides a preparation method of herbal skin-friendly mosquito-proof spray, which comprises the following steps:
(1) Weighing the plant components, the C2-C10 polyalcohol compounds, the plant thickening agent, the acid preservative and the deionized water according to a proportion, adding the mixture into a stirrer, and stirring for 1-3 hours to obtain a uniformly mixed mixture;
(2) And (2) filling the mixture obtained in the step (1) into a spray bottle to obtain the herbal skin-friendly mosquito-proof spray.
Compared with the prior art, the invention has the following beneficial effects:
1. according to the herbal skin-friendly mosquito-repellent spray prepared by the invention, the musk extract, the folium artemisiae argyi extract, the rhizoma atractylodis extract and the anemone vitifolia extract are added, and the active components of the musk extract, the folium artemisiae argyi extract, the rhizoma atractylodis extract and the anemone vitifolia extract have synergistic effects to achieve the effects of relieving itching, diminishing swelling and repelling mosquitoes.
2. The herbal skin-friendly anti-mosquito spray prepared by the invention is suitable for areas with hot weather and low humidity, and is prepared by adding the following components in a mass ratio of 0.5: (1-2): the mixture of the glycerin, the xylitol and the 1,2 hexanediol in the formula (1-2) solves the problems of easy volatilization of mosquito repellent components, short curative effect, poor system stability and the like in the prior art. The glycerol, the xylitol and the 1,2 hexanediol are added into the system, so that the glycerol, the xylitol and the 1,2 hexanediol are cooperated with one another on the premise of ensuring that the anti-mosquito active ingredients in the plant extract are not damaged, the moisture retention performance of the herbal skin-friendly anti-mosquito spray is obviously enhanced, the viscosity of the system is improved, the stability of the system is improved, the use comfort of the anti-mosquito spray is improved, and the phenomenon of acne growth is avoided;
3. according to the herbal skin-friendly anti-mosquito spray, pectin is added into a system, and on the premise that the herbal skin-friendly anti-mosquito spray has excellent effects of relieving swelling and pain, polar groups in the pectin interact with protein components in the musk guangdongensis extract, so that water and oil of skin are promoted to be balanced, meanwhile, bacteria are prevented from invading, and the antibacterial performance of the system is enhanced;
4. the herbal skin-friendly anti-mosquito spray prepared by the invention is prepared by adding the components in a mass ratio of 0.5:1, when the mixture of salicylic acid and octanoyl hydroxamic acid is used as a preservative, polar groups in the salicylic acid and the octanoyl hydroxamic acid interact with active ingredients in the plant extract, so that the compatibility of the plant extract in a system is obviously improved, mosquito repellent ingredients in the plant extract can fully play a role, the stability of the system is increased, and the action time of herbal skin-friendly mosquito repellent spray is prolonged.
5. The herbal skin-friendly and mosquito-repellent spray prepared by the invention achieves the best effect through the synergistic effect of the mint in the system. Terpenoids in the mint interact with cellulose and protein compounds in the plant extract, so that on one hand, the interrelation among all components in the system is enhanced, the compatibility of the mint in the system is improved, and the phenomenon of layering of herbal skin-friendly anti-mosquito spray is avoided; on the other hand, the anti-inflammatory effect and the antibacterial effect of the herbal skin-friendly and anti-mosquito spray are remarkably improved.
Detailed Description
Examples
Example 1
Embodiment 1 provides a mosquito-proof spraying of parent muscle of herbage, by weight, the raw materials include: 0.5 part of plant component, 15 parts of C2-C10 polyalcohol compound, 0.5 part of plant thickening agent, 0.1 part of acid preservative and 85 parts of deionized water.
The plant components comprise plant extracts and mint, wherein the mass ratio of the plant extracts to the mint is 1:0.5; the plant extract is a mixture of a musk grandiflorum extract, a folium artemisiae argyi extract, a rhizoma atractylodis extract and a sunflower extract, and the mass ratio of the musk grandiflorum extract, the folium artemisiae argyi extract, the rhizoma atractylodis extract and the sunflower extract is 0.5:0.2:0.3:1, the musk extract is purchased from Ningxia vanilla Biotechnology Co., ltd; the folium artemisiae argyi extract and the rhizoma atractylodis extract are purchased from Shanxi Xintianyuan Biotech limited company; the mallow extract is purchased from natural biological products limited of Shaanxi Yanling; mint is available from Shanghai Kanglang Biotech, inc. The C2-C10 polyalcohol compounds are a mixture of glycerol, xylitol and 1,2 hexanediol, wherein the mass ratio of the glycerol to the xylitol to the 1,2 hexanediol is 0.5:1.5:1.5; glycerol has CAS number 56-81-5; the CAS number of the xylitol is 87-99-0;1, 2-hexanediol has CAS number 6920-22-5. The plant thickening agent is pectin, and the CAS number of the pectin is 9000-69-5. The acid preservative is a mixture of salicylic acid and caprylyl hydroxamic acid, wherein the mass ratio of the salicylic acid to the caprylyl hydroxamic acid is 0.5:1, the CAS number of salicylic acid is 69-72-7; the CAS number of the octanoyl hydroxamic acid is 7377-03-9. The deionization was purchased from shell chemical, inc.
The preparation method of the herbal muscle-philic and mosquito-proof spray comprises the following steps:
(1) Weighing the plant components, the C2-C10 polyalcohol compounds, the plant thickening agent, the acid preservative and the deionized water according to a proportion, adding the mixture into a stirrer, and stirring for 2 hours to obtain a uniformly mixed mixture;
(2) And (2) filling the mixture obtained in the step (1) into a spray bottle to obtain the herbal skin-friendly mosquito-proof spray.
Example 2
Embodiment 2 provides a herbal skin-friendly and mosquito-repellent spray, which comprises the following raw materials in parts by weight: 2 parts of plant components, 20 parts of C2-C10 polyalcohol compounds, 1 part of plant thickening agent, 0.3 part of acid preservative and 95 parts of deionized water.
The plant components comprise plant extracts and mint, wherein the mass ratio of the plant extracts to the mint is 1:0.5; the plant extract is a mixture of musk guang extract, folium artemisiae argyi extract, rhizoma atractylodis extract and sunflower extract, and the mass ratio of musk guang extract, folium artemisiae argyi extract, rhizoma atractylodis extract and sunflower extract is 0.5:0.2:0.3:1, the musk extract is purchased from Ningxia vanilla biotech Co., ltd; the folium artemisiae argyi extract and the rhizoma atractylodis extract are purchased from Shanxi Xintianyuan Biotech limited company; the mallow extract is purchased from natural biological products limited of Shaanxi Yanling; mint is available from Shanghai Kanglang Biotech, inc. The C2-C10 polyalcohol compounds are a mixture of glycerol, xylitol and 1,2 hexanediol, wherein the mass ratio of the glycerol to the xylitol to the 1,2 hexanediol is 0.5:1.5:1.5, CAS number for glycerol is 56-81-5; the CAS number of the xylitol is 87-99-0;1, 2-hexanediol has CAS number 6920-22-5. The plant thickening agent is pectin, and the CAS number of the pectin is 9000-69-5. The acid preservative is a mixture of salicylic acid and octanoyl hydroxamic acid, wherein the mass ratio of the salicylic acid to the octanoyl hydroxamic acid is 0.5:1, the CAS number of salicylic acid is 69-72-7; the CAS number of the octanoyl hydroxamic acid is 7377-03-9. The deionization was purchased from shell chemical, inc.
The preparation method of the herbal muscle-attracting and mosquito-preventing spray is the same as that of example 1.
Example 3
Embodiment 3 provides a herbal skin-friendly and mosquito-repellent spray, which comprises the following raw materials in parts by weight: 1 part of plant component, 18 parts of C2-C10 polyalcohol compounds, 0.6 part of plant thickening agent, 0.2 part of acid preservative and 90 parts of deionized water.
The plant components comprise plant extracts and mint, wherein the mass ratio of the plant extracts to the mint is 1:0.5; the plant extract is a mixture of a musk grandiflorum extract, a folium artemisiae argyi extract, a rhizoma atractylodis extract and a sunflower extract, and the mass ratio of the musk grandiflorum extract, the folium artemisiae argyi extract, the rhizoma atractylodis extract and the sunflower extract is 0.5:0.2:0.3:1, the musk extract is purchased from Ningxia vanilla biotech Co., ltd; the folium artemisiae argyi extract and the rhizoma atractylodis extract are purchased from Shanxi Xintianyuan Biotech limited company; the mallow extract is purchased from natural biological products limited of Shaanxi Yanling; mint is available from Shanghai Kanglang Biotech, inc. The C2-C10 polyalcohol compounds are a mixture of glycerol, xylitol and 1,2 hexanediol, wherein the mass ratio of the glycerol to the xylitol to the 1,2 hexanediol is 0.5:1.5:1.5, CAS number for glycerol is 56-81-5; the CAS number of the xylitol is 87-99-0;1, 2-hexanediol has CAS number 6920-22-5. The plant thickening agent is pectin, and the CAS number of the pectin is 9000-69-5. The acid preservative is a mixture of salicylic acid and octanoyl hydroxamic acid, wherein the mass ratio of the salicylic acid to the octanoyl hydroxamic acid is 0.5:1, the CAS number of salicylic acid is 69-72-7; the CAS number of the octanoyl hydroxamic acid is 7377-03-9. The deionization was purchased from shell chemical, inc.
The preparation method of the herbal skin-friendly mosquito-repellent spray is the same as that of example 1.
Comparative example 1
Comparative example 1 the specific embodiment is the same as example 3 except that no sunflower extract is added.
Comparative example 2
Comparative example 2 the specific embodiment is the same as example 3 except that the C2-C10 polyol compound is ethanol.
Comparative example 3
Comparative example 3 a specific embodiment was the same as example 3 except that the vegetable thickener was replaced with polysorbate-80.
Comparative example 4
Comparative example 4A specific embodiment is the same as example 3 except that the acid preservative is replaced with methylparaben.
Evaluation of Properties
The performance test was performed on the herbal skin-friendly anti-mosquito sprays prepared in examples 1 to 3 and comparative examples 1 to 4.
Referring to table 1, table 1 shows the measurement data of the herbal skin-friendly anti-mosquito spray performance obtained in examples 1 to 3 and comparative examples 1 to 4.
(1) And (3) testing the stability:
5mL of the mosquito repellent liquid in the herbal skin-friendly mosquito-repellent spray prepared in the examples 1 to 3 and the comparative examples 1 to 4 is taken out and placed in a 10mL test tube, and the test tube is placed at 25 ℃ for a week to observe whether layering occurs or not.
The delamination phenomenon does not occur and is I level,
the occurrence of delamination was grade II.
(2) And (3) testing antibacterial performance:
the content of Staphylococcus aureus is 0.76 × 10 7 2 mu L of the mosquito repellent liquid in the herbal skin-friendly mosquito-repellent spray prepared in the examples 1-3 and the comparative examples 1-3 is added into the cuvette, and the content of staphylococcus aureus in the cuvette is detected after 14 days.
TABLE 1
Claims (10)
1. The herbal skin-friendly mosquito-repellent spray is characterized by comprising the following components in parts by weight: 0.5 to 2 parts of plant component, 15 to 20 parts of C2 to C10 polyalcohol compound, 0.5 to 1 part of plant thickening agent, 0.1 to 0.3 part of acid preservative and 85 to 95 parts of deionized water.
2. The herbal, muscle-philic and mosquito-repellent spray as claimed in claim 1, wherein the plant component is a mixture of plant extract and mint, and the mass ratio of the plant extract to the mint is 1: (0.2-0.8).
3. The herbal skin-friendly mosquito-repellent spray according to claim 2, wherein the plant extract is a mixture of a eurycoma longituba extract, a mugwort leaf extract, an atractylodes rhizome extract and a pelargonium vulgaris extract, and the mass ratio of the eurycoma longituba extract, the mugwort leaf extract, the atractylodes rhizome extract and the pelargonium vulgaris extract is (0.2-0.6): (0.1-0.3): (0.2-0.4): (0.5-1.5).
4. The herbal muscle-philic and mosquito-repellent spray as claimed in claim 1, wherein the C2-C10 polyol compound is at least one of glycerol, 1, 3-butylene glycol, hexylene glycol, xylitol and hexylene glycol.
5. The herbal, muscle-tropic, mosquito-repellent spray according to claim 1, wherein the C2-C10 polyol compound is a mixture of glycerol, xylitol, and 1,2 hexanediol.
6. The herbal skin-friendly mosquito-repellent spray according to claim 5, wherein the mass ratio of the glycerol to the xylitol to the 1, 2-hexanediol is 0.5: (1-2): (1-2).
7. The herbal, muscle-tropic, mosquito-repellent spray according to claim 1, wherein the plant thickening agent is pectin.
8. The herbal, muscle-tropic, mosquito-repellent spray according to claim 1, wherein the acid preservative is at least one of benzoic acid, levulinic acid, sorbic acid, salicylic acid, octanoyl hydroxamic acid.
9. The herbal, muscle-tropic and mosquito-repellent spray according to claim 1, wherein the acid preservative is a mixture of salicylic acid and octanoyl hydroxamic acid, and the mass ratio of the salicylic acid to the octanoyl hydroxamic acid is (0.2-1.2): 1.
10. a process for the preparation of an herbal, muscle-tropic, mosquito-repellent spray according to any one of claims 1 to 9, comprising the steps of:
(1) Weighing the plant components, the C2-C10 polyalcohol compounds, the plant thickening agent, the acid preservative and the deionized water according to a proportion, adding the mixture into a stirrer, and stirring for 1-3 hours to obtain a uniformly mixed mixture;
(2) And (2) filling the mixture obtained in the step (1) into a spray bottle to obtain the herbal skin-friendly mosquito-proof spray.
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