CN112402323A

CN112402323A - Spot-fading composition, cosmetic and preparation method of spot-fading composition

Info

Publication number: CN112402323A
Application number: CN202011432946.7A
Authority: CN
Inventors: 苏秀妹; 李柳波; 向密; 黄振振; 董圣祖; 曹波; 杨菊
Original assignee: Guangdong Bailichen Biotechnology Co ltd
Current assignee: Guangdong Bailichen Biotechnology Co ltd
Priority date: 2020-12-09
Filing date: 2020-12-09
Publication date: 2021-02-26
Anticipated expiration: 2040-12-09
Also published as: CN112402323B

Abstract

The invention discloses a spot-fading composition, and relates to the technical field of cosmetics. The spot-fading composition comprises the following components in parts by weight: 2-10 parts of glycyrrhiza glabra root extract, 1-10 parts of phyllanthus emblica fruit extract, 5-15 parts of raspberry extract and 1-3 parts of seaweed extract. The spot-fading composition provided by the invention can concentrate spot fading, can keep the skin moisture continuously, and is warm and non-irritant when used.

Description

Spot-fading composition, cosmetic and preparation method of spot-fading composition

Technical Field

The invention relates to the technical field of cosmetics, in particular to a spot-fading composition, a cosmetic and a preparation method thereof.

Background

Among many cultural and aesthetic trends, whitening or having a whiter skin color is an important factor in evaluating the beauty of women. The facial color spot refers to spots with different colors on the face and the periphery, the causes are many, the types are complex, the functions of melanocytes are enhanced mainly due to factors such as hereditary factors, ultraviolet irradiation, endocrine reasons, living habits and the like, the activity of free radicals is enhanced, the synthesis speed of melanin is far higher than the metabolism speed, abnormal melanin is absorbed by basal layer cells, and when the skin is repeatedly stimulated by the outside, the melanin is gradually shown on the epidermis, so the facial color spot is formed. And with the increase of age, the living pressure is higher, many people often go on a business trip, work outdoors, stay up night, face the screen of an electronic product for a long time, and the like, and do not pay attention to skin care for a long time, and in addition, the external environment pollution causes the ultraviolet rays to damage the skin more and more, so that melanin is continuously precipitated, and the skin becomes dark and speckled. In addition to the non-exclusive route of melanin formation, the activity of melanocytes is complex and variable.

The whitening products sold in the market at present mainly use the combination and matching of the following schemes: 1. 3-o-ethyl ascorbic acid, 2, Symwhite 377 phenethyl resorcinol, 3, niacinamide, 4, AA2G, 5, undecylenoyl phenylalanine, 6, arbutin, 7, octanoyl salicylic acid, 8, 4-methoxy potassium salicylate, 9, dimethoxy tolyl-4-propyl resorcinol.

However, some skin care products with whitening effect on the market have single mechanism pathway acting on melanin, and the whitening effect is not obvious; some contain irritant chemical components, and the skin becomes sensitive after long-term use and is more prone to aging; some products have single function, or only have whitening function, or only have freckle removing function; some are not stable and are prone to discoloration or deactivation. Therefore, the development and development of a skin whitening and caring product which is safe and mild to the skin and can effectively give consideration to the functions of spot lightening, moisture retention and repairing is particularly necessary.

Disclosure of Invention

Based on the above, the invention aims to overcome the defects of the prior art and provide a spot-fading composition which can concentrate spot fading, keep the skin moisture continuously, and is mild and non-irritant.

In order to achieve the purpose, the technical scheme adopted by the invention is as follows: a spot-lightening composition comprises the following components in parts by weight: 2-10 parts of glycyrrhiza glabra root extract, 1-10 parts of phyllanthus emblica fruit extract, 5-15 parts of raspberry extract and 1-3 parts of seaweed extract.

Wherein, the emblic extract is purchased from Baihabo company of Guangzhou; glycyrrhiza glabra root extract, available from Guangzhou Rongdao chemical company; rubi fructus extract and Sargassum extract are obtained from chemical engineering Co., Ltd, Xinan, Foshan.

According to the invention, the glycyrrhiza glabra root extract, the phyllanthus emblica fruit extract, the seaweed extract and the raspberry extract are compounded for use, and the melanin is comprehensively sniped to form by acting on various paths, so that the skin can achieve the effects of whitening, moisturizing and relieving.

The stain is formed by accumulation of melanin in the epidermis, which is produced by melanocytes. Tyrosine on a melanosome of melanocytes forms dopa under the catalysis of tyrosinase, and dopa further reduces the oxidation resistance under the action of free radicals under the action of an oxidation mechanism to form dopaquinone and directly promote the aggregation of melanin. Inhibition of tyrosinase activity and elimination of free radicals are therefore the main routes for reducing pigmentation.

The glabridin contained in the glabrous greenbrier rhizome extract can act on various paths at the same time, snipe melanin comprehensively, is unique and rare licoflavone, and exists only at the root of glabrous greenbrier rhizome. The extract of glabrous greenbrier rhizome is effective in inhibiting tyrosinase, dopachrome tautomerase and melanogenesis. Glabridin also has good anti-inflammatory effect; it is effective in scavenging oxygen free radicals. Protect the skin from the source, and is more thorough and more healthy!

The emblic leafflower fruit extract is a substance separated and extracted from emblic leafflower fruit, and is a freckle-removing whitening agent derived from purely natural plant fruits. The emblic leafflower fruit extract can inhibit the synthesis of tyrosinase without affecting the expression of the tyrosinase; the whitening effect is achieved by inhibiting MSH → reducing the content of tyrosinase → reducing melanin.

The seaweed contains rich alginic acid, crude protein, multiple vitamins and trace elements such as potassium, calcium, copper and zinc, and can effectively maintain healthy growth of epithelial tissues, promote skin moisture absorption, inhibit synthesis of melanin in skin, and reduce generation of pigment spots.

The raspberry contains a large amount of organic acids, saccharides, vitamin C and other nutrients, wherein the organic acids and the vitamin C can remove free radicals and resist the damage of the free radicals to cells, so that skin is lightened, spots are lightened, and the activity of tyrosinase can be inhibited to block the formation of melanin.

Further preferably, the spot-fading composition comprises the following components in parts by weight: 4-8 parts of glycyrrhiza glabra root extract, 5-10 parts of phyllanthus emblica fruit extract, 8-12 parts of raspberry extract and 1-3 parts of seaweed extract.

The glabrous greenbrier rhizome extract and the emblic leafflower fruit extract can effectively inhibit the synthesis of tyrosinase, the raspberry extract can inhibit the activity of the tyrosinase and remove free radicals, and the seaweed extract can inhibit the formation of melanin. Therefore, the glabrous greenbrier rhizome extract, the emblic leafflower fruit extract, the raspberry extract and the seaweed extract inhibit the formation of pigment from each stage of melanin formation, thereby playing a spot-lightening effect; it also has effects in promoting skin growth, and improving cell repair and water absorption.

More preferably, the spot-fading composition comprises the following components in parts by weight: 5 parts of glycyrrhiza glabra root extract, 6 parts of emblic leafflower fruit extract, 10 parts of raspberry extract and 2 parts of seaweed extract.

In addition, the invention also provides application of the spot-fading composition in cosmetics, wherein the cosmetics are at least one of essence, facial mask, emulsion or cream.

Further, the present invention also provides a cosmetic comprising the spot-fading composition.

Preferably, the cosmetic comprises the following components in parts by weight: 0.1-2 parts of spot-fading composition, 0.1-5 parts of thickening agent, 5-15 parts of emollient, 5-15 parts of humectant, 0.1-5 parts of emulsifier and 0.05-1 part of preservative.

Further preferably, the cosmetic is a spot-lightening emulsion which comprises the following components in parts by weight: 1-2 parts of spot-fading composition, 1-3 parts of thickening agent, 5-10 parts of emollient, 5-10 parts of grease, 1-3 parts of emulsifier and 0.1-0.5 part of preservative.

More preferably, the spot-fading emulsion comprises the following components in parts by weight: 1.5 parts of spot-fading composition, 2 parts of thickening agent, 10 parts of emollient, 5 parts of grease, 2 parts of emulsifier and 0.3 part of preservative.

Wherein, the cosmetic can be added with or without essence, pigment or active ingredients according to the requirements of consumers.

Preferably, the cosmetic is at least one of the following (a) to (e):

(a) the thickening agent is at least one of carbomer, pectin, xanthan gum, hydroxyethyl cellulose and acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer;

(b) the emulsifier is at least one of cetostearyl alcohol, stearyl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, glyceryl stearate, sorbitan stearate, methyl glucose sesquistearate, and PEG-20 methyl glucose sesquistearate;

(c) the emollient is at least one of glycerol, propylene glycol, butanediol, pentanediol, allantoin, and sodium hyaluronate;

(d) the oil is at least one of jojoba oil, macadamia nut seed oil, shea butter, olive oil, caprylic/capric triglyceride, and PEG-6 caprylic/capric triglyceride.

(e) The antiseptic is at least one of phenoxyethanol, caprylyl hydroximic acid, benzyl alcohol, ethylhexyl glycerol, p-hydroxyacetophenone, 1, 2-hexanediol, sodium benzoate and sodium salicylate.

In addition, the invention also provides a preparation method of the cosmetic, which comprises the following steps:

(1) adding water, thickener and emollient into water phase pot, heating to 75-80 deg.C, dissolving completely, and keeping the temperature for 10-15min to obtain water phase mixture;

(2) adding emulsifier and oil into oil phase pan, heating to 75-80 deg.C, dissolving completely, and keeping the temperature for 10-15min to obtain oil phase mixture;

(3) sequentially adding the water phase mixture prepared in the step (1) and the oil phase mixture prepared in the step (2) into an emulsifying pot, uniformly stirring, and homogenizing and emulsifying to obtain a mixture;

(4) cooling the mixture obtained in the step (3) to 50-55 ℃, adding the spot-fading composition, uniformly stirring, cooling to 40-45 ℃, adding the preservative, uniformly stirring, cooling to 25-30 ℃, and discharging to obtain the cosmetic.

Preferably, in the step (3), the temperature for homogenization is 75-80 ℃, the rate for homogenization is 2500-3500r/min, and the time for homogenization is 5-10 min.

Compared with the prior art, the invention has the beneficial effects that: the spot-fading composition disclosed by the invention simultaneously contains the glycyrrhiza glabra root extract, the emblic leafflower fruit extract, the raspberry extract and the seaweed extract, and the formation of pigment is inhibited from each stage of melanin formation, so that the spot-fading effect is achieved.

Detailed Description

To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.

The present application sets forth the components and parts by weight of examples 1-5, specific examples 1-5 as shown in tables 1, 2 and 3, wherein the parts by weight of the total components of the spot-fading emulsion described in the examples are 100 parts:

table 1 examples 1-5 selection of parts by weight of spot-lightening composition

Spot-lightening composition	Example 1	Example 2	Example 3	Example 4	Example 5
						Glycyrrhiza glabra root extract	2	10	4	8	5
Phyllanthus emblica fruit extract	10	1	10	5	6
						Raspberry extract	5	15	8	12	10
Seaweed extract	3	1	3	1	2

Table 2 examples 1-5 selection of parts by weight of spot-lightening emulsion

	Example 1	Example 2	Example 3	Example 4	Example 5
						Spot-lightening composition	0.1	2	1	2	1.5
Thickening agent	5	0.1	3	1	2
						Skin-moistening agent	5	15	10	8	10
Oil and fat	15	5	8	10	5
						Emulsifier	5	0.1	3	1	2
Preservative	1	0.05	0.5	0.1	0.3
						Water (W)	Balance of	Balance of	Balance of	Balance of	Balance of

TABLE 3 example 1-5 selection of components for spot-lightening emulsions

The preparation method of the spot-fading emulsion described in the example comprises the following steps after weighing the components according to the table 1, the table 2 and the table 3:

Meanwhile, the application sets comparative examples 1-10, the weight parts of the spot-fading compositions of the comparative examples 1-10 are selected as shown in the table 4, and the rest components and the weight parts selection and preparation method are completely the same as those of the example 5:

TABLE 4 selection of parts by weight of comparative examples 1-10 speckle-reducing compositions

Test example 1DPPH radical scavenging Rate test

A sample to be tested: the spot-fading emulsions of examples 1 to 5 and comparative examples 1 to 10;

reagent: 1, 1-diphenyl-2-trinitrophenylhydrazine (DPPH), absolute ethanol;

preparing a sample to be tested: respectively taking 20mg of the spot-fading emulsion of the examples 1-5 and the comparative examples 1-10, dissolving the spot-fading emulsion by using absolute ethyl alcohol, and fixing the volume to 250mL for later use;

preparation of DPPH: accurately weighing 20mg of DPPH, dissolving with absolute ethyl alcohol, and fixing the volume to 250mL for later use;

the instrument comprises the following steps: an ultraviolet visible spectrophotometer and a thermostat;

the method comprises the following steps: placing 2mL of the prepared sample to be tested and 2mL of DPPH solution into a test tube with a sieve, placing the test tube in an incubator at a constant temperature of 37 ℃ for 1h, taking absolute ethyl alcohol as a blank control, measuring the absorbance A1 of each sample to be tested at 517nm, and calculating the clearance rate according to the following formula:

clearance ═ 1- (a1-a2)/a0 × 100%

Wherein, A0: absorbance of 2mL absolute ethanol plus 2mL DPPH ethanol solution (control test);

a1: absorbance of 2mL of test agent plus 2mL of ethanol solution of DPPH;

a2: absorbance of 2mL of test agent plus 2mL of absolute ethanol solution (blank test);

three groups of parallel samples are measured on each sample to be measured, and the average value is obtained, and the result is shown in the following table 5:

test example 2 Activity for scavenging hydroxyl radical

The testing process comprises the following steps: antioxidant activity is expressed in terms of the ability to scavenge hydroxyl radicals. 1.5ml of 1.8mol/l salicylic acid solution is mixed with 2.0ml of 1.8mol/l FeSO₄After the solution was mixed well in a test tube, 2.0g of the above spot-fading emulsions of examples 1 to 5 and comparative examples 1 to 10 were added, respectively, followed by 0.1ml of 0.3mol/l H₂O₂Shaking, keeping the temperature at 37 ℃ for 30min, and measuring the absorbance value at 510 nm; each group was replicated 3 times, averaged, and the test results are shown in table 5:

the calculation method of the hydroxyl radical inhibition rate comprises the following steps: inhibition [% ], [% ] (A1+ A3-A2)/A1 [% 100 ].

A1: deionized water replacing absorbance of sample to be measured

A2: adding the absorbance of the sample to be measured

A3: without addition of H only₂O₂Absorbance of (A)

TABLE 5 test results

And (4) conclusion: the removal rate of scavenging radicals of examples 1 to 5 was higher than that of comparative examples 1 to 10. Because examples 1-5 are synergistic effects between the glycyrrhiza glabra root extract, the emblic leafflower fruit extract, the raspberry extract and the seaweed extract, the DPPH and hydroxyl radical clearance rate is improved and is better than that of comparative examples 1-10; thereby inhibiting the generation and accumulation of melanin and realizing the effects of lightening spots and whitening skin. Comparative examples 1-4 are the above extracts wherein three of the synergistic effects are inferior to the synergistic effects of the total extract; thus, comparative examples 5 to 8 are the above-mentioned extracts in which two synergistic effects are inferior to those of comparative examples 1 to 4, and comparative examples 9 and 10 are only the extracts alone having no synergistic effect, and it is clear that the effect of the free radicals is not so good.

Test example 3 melanin test

The skin melanin tester MX 18 of the German CK company is used for testing, the testing environment temperature is 22 +/-1 ℃, and the humidity is 50 +/-5%; the test part is the inner forearm of the two hands and is marked by a test area of 4 x 4cm2, the test part can not be used for any other product for 3 days, the product can be used for 2 times in 1 day, and the dosage of each time is 2.0 +/-0.1 mg/cm²Applied to left and right arms for 1 month, and visit every week. And (3) allowing the test subject to enter a constant-temperature and constant-humidity evaluation room for standing for 30 minutes, testing the melanin content of the face before and after use, and counting the melanin reduction rate.

Melanin reduction rate/% (initial value of skin melanin at 0 th-skin melanin test value)/initial value of skin melanin at 0 th.

The test results are shown in table 6:

TABLE 6 Melanin Change Rate

And (4) conclusion: the results of experiments in examples 1 to 5, in which the melanin reduction rate was higher than that in comparative examples 1 to 10, show that the melanin content was lower after 1 month of use than before trial use. Since examples 1 to 5 are synergistic effects among the components of glycyrrhiza glabra root extract, emblic leafflower fruit extract, raspberry extract and seaweed extract, the melanin reduction rate is relatively high and the content is reduced to achieve the whitening and spot-lightening effects. Comparative examples 1-4 are the above extracts wherein three of the synergistic effects are inferior to the synergistic effects of the total extract; therefore, the comparative examples 5 to 8 are that two of the above extracts have less synergistic effect than the comparative examples 1 to 4, and the comparative examples 9 and 10 are that the extracts alone have no synergistic effect, and the whitening and spot-lightening effect is not good.

Test example 4

The spot-fading compositions of examples 1 to 5 and comparative examples 1 to 10 were subjected to evaluation of efficacy by the method using a skin tester, CK MPA10, moisture test probe. 150 healthy volunteers aged 18-50 were selected and randomized into 15 groups, and the face was selected as the test area.

Preparation before testing: the volunteers could not use any cosmetics 2-3 days before the test site. Volunteers cleaned their faces before testing and sat still for at least 20min in a standard room at a temperature of 20-25 ℃ and a humidity of 45-65%.

The testing steps are as follows: measuring an initial value of moisture content of the skin in a test area by using a moisture test probe; then according to the ratio of 0.072mg/cm²The dosage of the composition is applied to face twice a day, and continuously used for one month. The test area was tested for skin moisture content on day 14 and day 28, respectively. The testing of the same volunteer was done by the same measurement staff.

Test data: the increase rate of skin moisture content = (skin moisture test value-initial value before test)/initial value before test 100%, and the test results are shown in table 7:

TABLE 7 increase rate of skin moisture content

And (4) conclusion: the experimental results of the samples of examples 1 to 5, which are higher in skin moisture increase rate than the samples of comparative examples 1 to 10, show that the products of examples 1 to 5 have the effects of repairing and moisturizing, because examples 1 to 5 are synergistic effects among the components of glycyrrhiza glabra root extract, emblica officinalis fruit extract, coppery herb extract and seaweed extract, reduce melanin, enhance skin barrier and promote skin repair. Comparative examples 1-4 are the above extracts wherein three of the synergistic effects are inferior to the synergistic effects of the total extract; therefore, the comparative examples 5 to 8 are that two of the extracts have a less synergistic effect than the comparative examples 1 to 4, and the comparative examples 9 and 10 are that only the extracts alone have no synergistic effect, and the repairing and moisturizing effects are not good.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. The spot-fading composition is characterized by comprising the following components in parts by weight: 2-10 parts of glycyrrhiza glabra root extract, 1-10 parts of phyllanthus emblica fruit extract, 5-15 parts of raspberry extract and 1-3 parts of seaweed extract.

2. The spot-lightening composition of claim 1, comprising the following components in parts by weight: 4-8 parts of glycyrrhiza glabra root extract, 5-10 parts of phyllanthus emblica fruit extract, 8-12 parts of raspberry extract and 1-3 parts of seaweed extract.

3. The spot-lightening composition of claim 2, comprising the following components in parts by weight: 5 parts of glycyrrhiza glabra root extract, 6 parts of emblic leafflower fruit extract, 10 parts of raspberry extract and 2 parts of seaweed extract.

4. Use of a spot-lightening composition according to any one of claims 1 to 3 in cosmetics.

5. A cosmetic comprising the spot-fading composition according to any one of claims 1 to 3.

6. The cosmetic according to claim 5, wherein the cosmetic is a spot-lightening emulsion comprising the following components in parts by weight: 0.1-2 parts of spot-fading composition, 0.1-5 parts of thickening agent, 5-15 parts of emollient, 5-15 parts of grease, 0.1-5 parts of emulsifier and 0.05-1 part of preservative.

7. The cosmetic according to claim 6, comprising the following components in parts by weight: 1-2 parts of spot-fading composition, 1-3 parts of thickening agent, 5-10 parts of emollient, 5-10 parts of grease, 1-3 parts of emulsifier and 0.1-0.5 part of preservative.

8. The cosmetic according to claim 7, comprising the following components in parts by weight: 1.5 parts of spot-fading composition, 2 parts of thickening agent, 10 parts of emollient, 5 parts of grease, 2 parts of emulsifier and 0.3 part of preservative.

9. The cosmetic according to any one of claims 5 to 8, wherein at least one of the following (a) to (e):

(c) the emollient is at least one of glycerol, propylene glycol, butanediol, pentanediol, allantoin and sodium hyaluronate;

(d) the grease is at least one of jojoba oil, macadamia nut seed oil, shea butter, olive oil, caprylic/capric triglyceride and PEG-6 caprylic/capric glyceride;

10. A method for preparing a cosmetic product according to any one of claims 5 to 9, comprising the steps of: