CN109331110A - A kind of composition with swelling and pain relieving, medicament and preparation method - Google Patents
A kind of composition with swelling and pain relieving, medicament and preparation method Download PDFInfo
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- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract
Have effects that the composition of swelling and pain relieving, raw material include garlic oil, safflower extract, heat sensitizer, penetrating agent, stearic acid, cetostearyl alcohol, Jojoba seed oil, ethylhexyl palmitate, peppermint oil and borneol the present invention provides a kind of.Has effects that the medicament of swelling and pain relieving the present invention also provides a kind of, which includes composition, antiseptic ingredient and rush absorbent components.In composition of the invention, it has been used cooperatively garlic oil and safflower extract, swelling and pain relieving effect is obvious, and the present invention is used using the two kinds of natural plant extracts collocation of prickly pear extract and aloe extract, has good anti-corrosion effect, the product being prepared has the longer shelf-life, storage can be stablized, also there is anti-aging, reduce red capillary, the effects of promoting collagen synthesis, enhancing skin activity.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of composition with swelling and pain relieving, medicament and system
Preparation Method.
Background technique
Modern's plenty of time, which is all spent, to be chased after acute, object for appreciation game and is playing on mobile phone, lacks exercise, therefore channels and collaterals are not dredged,
QI-blood circulation has some setbacks, and influences the normal physiological function of internal organs, and physical fitness goes from bad to worse.External manifestation has shoulder neck, lumbar vertebrae, hand
Arm etc. pain is uncomfortable.
Alleviate the mainly white with cortex plaster and swelling and pain relieving of above-mentioned symptom at present.Traditional cortex plaster smell is denseer,
Poor air permeability easily causes certain damage to skin, absorbs slowly, ingredient is single, and remission effect is limited, patient's usage experience
Difference.And existing swelling and pain relieving frost, poor permeability, actual effect is bad, and often adds the chemical preservative being harmful to the human body.
Therefore, it still needs to develop a kind of new swelling and pain relieving composition.
Summary of the invention
To solve the problems of the prior art, an object of the present invention, which is to provide, a kind of has effects that the group of swelling and pain relieving
Close object.
The second object of the present invention is to provide a kind of to have effects that the medicament of swelling and pain relieving.
The third object of the present invention is to provide the preparation method of above-mentioned medicament.
To achieve the above object, the invention adopts the following technical scheme:
It is a kind of to have effects that the composition of swelling and pain relieving, the component including following parts by weight meter:
0.2~1 part of garlic oil,
0.2~2 part of safflower extract,
1~3 part of heat sensitizer,
0.5~3 part of penetrating agent,
5~8 parts of stearic acid,
5~8 parts of cetostearyl alcohol,
1~5 part of Jojoba seed oil,
20~30 parts of ethylhexyl palmitate,
0.1~0.5 part of peppermint oil,
0.1~0.5 part of borneol.
Preferably, the heat sensitizer is vanillyl butyl ether.
Preferably, the penetrating agent is the mixture that menthol and hydrolecithin are 1:1 in mass ratio.
It is a kind of to have effects that the medicament of swelling and pain relieving, including combinations of the above object, antiseptic ingredient and rush absorbent components.
Preferably, the antiseptic ingredient includes the raw material of following parts by weight meter:
0.3~0.5 part of pH adjusting agent,
0.5~1 part of prickly pear extract,
0.2~0.5 part of aloe extract.
Preferably, the pH adjusting agent is sodium hydroxide.
Preferably, described to promote the raw material that absorbent components include following parts by weight meter:
5~10 parts of moisturizer,
1~2 part of carbomer,
10~20 parts of water.
Preferably, the moisturizer is xylitol.
Preferably, the dosage form of the medicament is gel, emulsifiable paste and one of spraying.
A kind of preparation method with the medicament of swelling and pain relieving, comprising the following steps:
(1) each raw material of absorbent components will be promoted to be added in container 1, heating stirring；
(2) each raw material of composition is added in container 2, heating stirring；
(3) mixture in container 2 is added in container 1, is down to low temperature after high speed is homogeneous, adds uniformly mixed anti-corrosion
Component.
Preferably, step (1) and the temperature of (2) are 50~65 DEG C, and mixing time is 10~15min.
Preferably, the homogeneous revolving speed of step (3) described high speed is 3000rpm, and the low temperature is < 40 DEG C.
The present invention has effects that active effect of the composition of swelling and pain relieving mainly by vanillyl butyl ether and garlic oil
Collective effect provided.Vanillyl butyl ether is a kind of oil-soluble heat sensitizer, after acting locally on skin, can quickly generate temperature
With lasting pyrogenic effect, microcirculation can be accelerated, stimulation subcutaneous fat is metabolized, and promotes capillary blood circulation.Vanillyl fourth
The thermal sensation of base ether is the several times of general pepper extract, and irritation is low, and the time that thermal sensation is kept is up to a few hours, and can be
It can produce strong thermal sensation under extremely low dosage.Garlic oil may act on sympathetic nerve and vagal system, press after dilution
Rub the hemostasis that can dissipate, and treats wound.
The main component of cell membrane is phospholipid bilayer, makees emulsifier using hydrolecithin and replaces conventional emulsifier,
According to the similar principle that mixes, skin can be promoted preferably to absorb functional component, be further reduced in traditional chemical synthetic emulsifier
Existing specified risk material.
The greases such as dormant oil are replaced using plant Jojoba seed oil and ethylhexyl palmitate, reduce specified risk material, also,
Jojoba seed oil has good permeability, can promote the absorption of functional component, dimension life also rich in Jojoba seed oil
Plain D and protein, the pre- anti-wrinkle of energy and softening skin, there is good emollient, moisture retention.
Escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, Klebsiella Pneumoniae, mould must not be detected in cosmetics
Bacterium and saccharomycete etc..Preservative currently on the market is predominantly slow to hydroxy kind bacteriostatic agent, isothiazolinone bacteriostatic agent, formaldehyde
Release body bacteriostatic agent, alcohols bacteriostatic agent and parabens bacteriostatic agent.Wherein cosmetics relevant laws and regulations are antibacterial to isothiazolinone
Agent, formaldehyde sustained release bacteriostatic agent and parabens bacteriostatic agent have specific limitation dosage.And alcohols bacteriostatic agent such as Phenoxyethanol,
The sterilizing abilities such as 1,2~hexylene glycol are limited, and fungistatic effect is bad when single use, and Phenoxyethanol also has dioxanes
Risk.
Aloe extract contains anthraquinone analog compound, and anthraquinone can inhibit the synthesis of albumen and nucleic acid, so as to effectively press down
Make golden yellow staphylococcus, candidiasis, aspergillus oryzae and trichoderma.Ginger-root extract is to gold-coloured staphylococci, hay bacillus, black song
Mould, mould, Escherichia coli and brewer's yeast have stronger inhibiting effect.Schisandra chinens P.E is to Pseudomonas aeruginosa, kerekou pneumonia
The growth of primary Salmonella, Escherichia coli and staphylococcus aureus has very strong inhibiting effect, however is individually extracted with Schisandra chinensis
Object is weaker to the fungistatic effect of staphylococcus aureus, and individually Schisandra chinens P.E cannot antibacterial mould, arrange in pairs or groups ginger
It acts synergistically after root extract and aloe extract obvious, the anti-corrosion ability of system can be improved.The present invention uses Schisandra chinensis
Three kinds of extraction, aloe extract and ginger-root extract extracts have good bacteriostasis as protective system, and three kinds mention
The effects of taking object to have anti-aging, reducing red capillary, promote collagen synthesis, enhance skin activity, can not only reach anti-corrosion
Effect can also make skin more healthy.
Prickly pear is the fruit of opuntia, pulp microelement rich in, protein, amino acid, dimension
Raw element, polysaccharide, flavonoids and pectin etc., can promote the extension of human normal fibrocyte to regenerate, no matter also to body interior
It is that the healing of superficial wound all has great importance, in addition, prickly pear extract also has preservative efficacy.
Beneficial effects of the present invention
1, in composition of the invention, it has been used cooperatively garlic oil and safflower extract, swelling and pain relieving effect is obvious；
2, the present invention is used using the two kinds of natural plant extracts collocation of prickly pear extract and aloe extract, is had
Good anti-corrosion effect, the product being prepared have the longer shelf-life, can stablize storage, also have anti-aging, reduce red
The effects of trace of blood promotes collagen synthesis, enhances skin activity；
3, composition of the invention replaces chemical substance using natural materials, increases the security performance of product, moistens simultaneously
Skin, moistening effect and permeability are more preferable, replace the greases such as dormant oil using plant SIMMONDSIA CHINENSIS SEED OIL and ethylhexyl palmitate, have
Good permeability promotes the absorption of functional component；
4, compared with traditional plaster and existing swelling and pain relieving frost, the present invention uses vanillyl butyl ether and other compositions
Collocation uses, and enhances the absorption of drug component using the pyrogenic effect of heat sensitizer, can produce apparent swelling and pain relieving effect.
Specific embodiment
The following is specific embodiments of the present invention, and technical scheme of the present invention will be further described in conjunction with the embodiments,
However, the present invention is not limited to these examples.
Embodiment 1
It is a kind of to have effects that the composition of swelling and pain relieving, the component including following parts by weight meter:
0.2 part of garlic oil, 0.2 part of safflower extract, 1 part of heat sensitizer, 0.5 part of penetrating agent, 5 parts of stearic acid, cetearyl alcohol
5 parts of alcohol, 1 part, 20 parts of ethylhexyl palmitate, 0.1 part of peppermint oil, 0.1 part of borneol of oil of Jojoba seed.
Wherein, heat sensitizer is vanillyl butyl ether, and penetrating agent is that menthol and hydrolecithin are the mixed of 1:1 in mass ratio
Close object.
Embodiment 2
It is a kind of to have effects that the composition of swelling and pain relieving, the component including following parts by weight meter:
1 part of garlic oil, 2 parts of safflower extract, 3 parts of heat sensitizer, 3 parts of penetrating agent, 8 parts of stearic acid, 8 parts of cetostearyl alcohol,
5 parts, 30 parts of ethylhexyl palmitate, 0.5 part of peppermint oil, 0.5 part of borneol of oil of Jojoba seed.
Wherein, heat sensitizer is vanillyl butyl ether, and penetrating agent is that menthol and hydrolecithin are the mixed of 1:1 in mass ratio
Close object.
Embodiment 3
It is a kind of to have effects that the composition of swelling and pain relieving, the component including following parts by weight meter:
0.5 part of garlic oil, 1 part of safflower extract, 2 parts of heat sensitizer, 1.5 parts of penetrating agent, 6 parts of stearic acid, cetostearyl alcohol 6
Part, 3 parts, 25 parts of ethylhexyl palmitate, 0.3 part of peppermint oil, 0.3 part of borneol of oil of Jojoba seed.
Wherein, heat sensitizer is vanillyl butyl ether, and penetrating agent is that menthol and hydrolecithin are the mixed of 1:1 in mass ratio
Close object.
Embodiment 4
It is a kind of to have effects that the medicament of swelling and pain relieving, composition, antiseptic ingredient and rush absorbent components including embodiment 3.
Antiseptic ingredient includes the raw material of following parts by weight meter:
0.3 part of pH adjusting agent, 0.5 part of prickly pear extract, 0.2 part of aloe extract, pH adjusting agent is sodium hydroxide.
Promote the raw material that absorbent components include following parts by weight meter:
5 parts of moisturizer, 1 part of carbomer, 10 parts of water, moisturizer is xylitol.
Embodiment 5
It is a kind of to have effects that the medicament of swelling and pain relieving, composition, antiseptic ingredient and rush absorbent components including embodiment 3.
Antiseptic ingredient includes the raw material of following parts by weight meter:
0.5 part of pH adjusting agent, 1 part of prickly pear extract, 0.5 part of aloe extract, pH adjusting agent is sodium hydroxide.
Promote the raw material that absorbent components include following parts by weight meter:
10 parts of moisturizer, 2 parts of carbomer, 20 parts of water, moisturizer is xylitol.
Embodiment 6
It is a kind of to have effects that the medicament of swelling and pain relieving, composition, antiseptic ingredient and rush absorbent components including embodiment 3.
Antiseptic ingredient includes the raw material of following parts by weight meter:
0.4 part of pH adjusting agent, 0.7 part of prickly pear extract, 0.3 part of aloe extract, pH adjusting agent is sodium hydroxide.
Promote the raw material that absorbent components include following parts by weight meter:
7 parts of moisturizer, 1.5 parts of carbomer, 15 parts of water, moisturizer is xylitol.
Embodiment 7
Present embodiments provide the preparation method with the medicament of swelling and pain relieving, specific steps are as follows:
(1) each raw material of absorbent components will be promoted to be added in container 1, heating stirring；
(2) each raw material of composition is added in container 2, heating stirring；
(3) mixture in container 2 is added in container 1, is down to low temperature after high speed is homogeneous, adds uniformly mixed anti-corrosion
Component.
Step (1) and the temperature of (2) are 50~65 DEG C, and mixing time is 10~15min, step (3) described high speed
Homogeneous revolving speed is 3000rpm, and the low temperature is < 40 DEG C.
Detect example
Has effects that the drug effect of the composition of swelling and pain relieving obtained by the present invention to verify, we are living with certain commercially available money by it
Network cream has carried out comparative test.
Subjects totally 200 people exists because the reasons such as long-term sitting lead to that QI-blood circulation is unsmooth, shoulder neck pain asks
Subjects are randomly divided into 100 people of experimental group and control group people by topic, and experimental group use is formulated according to the embodiment of the present invention 6 and makes
A little emulsifiable paste is applied to sore place when use by standby emulsifiable paste, massages about 30s or so, and the same method of control group uses commercially available
Common blood circulation activating plaster.After a week, subjects are evaluated according to pain relief situation, and the results are shown in Table 1 for test.
1 present invention of table has effects that the composition effect comparison of swelling and pain relieving
| Group | Pain disappears | Pain obviously weakens | There is small effect | Without positive effect |
| Experimental group | 88 | 92 | 3 | 0 |
| Control group | 54 | 65 | 32 | 9 |
In addition, total Test object indicates that the composition with swelling and pain relieving provided by the invention exists in experimental group
It is fast to smear skin infiltration rate in massage processes, emulsifiable paste will not " floating " in skin surface, no greasy feeling, skin is relatively slided after smearing
Profit, has the using effect of similar body lotion and hand lotion, smell is unobvious, and total Test object does not occur skin during the test
The allergic phenomenas such as skin is rubescent, itches.In control group, indicate that used blood circulation activating plaster is more greasy more than 70% subjects,
Skin surface is glossy after smearing massage, there is grease, and blood circulation activating plaster does not fully penetrate into skin, indicates active more than 50% subjects
Cream spinosity excitation, local skin is rubescent after a week for continuous use, and blood circulation activating plaster smell is special and strong.
Claims (10)
1. a kind of have effects that the composition of swelling and pain relieving, which is characterized in that the component including following parts by weight meter:
0.2~1 part of garlic oil,
0.2~2 part of safflower extract,
1~3 part of heat sensitizer,
0.5~3 part of penetrating agent,
5~8 parts of stearic acid,
5~8 parts of cetostearyl alcohol,
1~5 part of Jojoba seed oil,
20~30 parts of ethylhexyl palmitate,
0.1~0.5 part of peppermint oil,
0.1~0.5 part of borneol.
2. according to claim 1 have effects that the composition of swelling and pain relieving, which is characterized in that the heat sensitizer is chinese cymbidium
Base butyl ether.
3. according to claim 1 have effects that the composition of swelling and pain relieving, which is characterized in that the penetrating agent is peppermint
Pure and mild hydrolecithin is the mixture of 1:1 in mass ratio.
4. a kind of have effects that the medicament of swelling and pain relieving, which is characterized in that including the described in any item combinations of claims 1 to 3
Object, antiseptic ingredient and rush absorbent components.
5. medicament according to claim 4, which is characterized in that the antiseptic ingredient includes the raw material of following parts by weight meter:
0.3~0.5 part of pH adjusting agent,
0.5~1 part of prickly pear extract,
0.2~0.5 part of aloe extract.
6. medicament according to claim 5, which is characterized in that the pH adjusting agent is sodium hydroxide.
7. medicament according to claim 4, which is characterized in that described to promote the original that absorbent components include following parts by weight meter
Material:
5~10 parts of moisturizer,
1~2 part of carbomer,
10~20 parts of water.
8. medicament according to claim 7, which is characterized in that the moisturizer is xylitol.
9. according to the described in any item medicaments of claim 4~8, which is characterized in that the dosage form of the medicament be gel, emulsifiable paste and
It is one of spraying.
10. a kind of preparation method with the medicament of swelling and pain relieving, which comprises the following steps:
(1) each raw material of absorbent components will be promoted to be added in container 1, heating stirring；
(2) each raw material of composition is added in container 2, heating stirring；
(3) mixture in container 2 is added in container 1, is down to low temperature after high speed is homogeneous, adds uniformly mixed anti-corrosion group
Point.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811356984.1A CN109331110A (en) | 2018-11-15 | 2018-11-15 | A kind of composition with swelling and pain relieving, medicament and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811356984.1A CN109331110A (en) | 2018-11-15 | 2018-11-15 | A kind of composition with swelling and pain relieving, medicament and preparation method |
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| CN109331110A true CN109331110A (en) | 2019-02-15 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115245529A (en) * | 2021-04-26 | 2022-10-28 | 上海幼官健康管理有限公司 | Skin penetrating agent and external pain relieving medicine prepared from same |
-
2018
- 2018-11-15 CN CN201811356984.1A patent/CN109331110A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115245529A (en) * | 2021-04-26 | 2022-10-28 | 上海幼官健康管理有限公司 | Skin penetrating agent and external pain relieving medicine prepared from same |
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190215 |
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| WW01 | Invention patent application withdrawn after publication |