CN114848567A

CN114848567A - Cool gel and preparation method thereof

Info

Publication number: CN114848567A
Application number: CN202210546503.3A
Authority: CN
Inventors: 许绍宝
Original assignee: Shantou Jinlong Daily Chemical Industry Co ltd
Current assignee: Shantou Jinlong Daily Chemical Industry Co ltd
Priority date: 2022-05-19
Filing date: 2022-05-19
Publication date: 2022-08-05

Abstract

The application relates to the technical field of skin care products, in particular to a cooling gel and a preparation method thereof. The cooling gel comprises the following raw materials in parts by weight: 3-6 parts of citronella oil, 1.5-3 parts of borneol, 0.05-0.5 part of golden chamomile extract, 0.01-1.0 part of eucalyptol, 0.03-0.2 part of lavender oil, 0.05-0.5 part of aloe extract, 0.1-0.2 part of chlorphenesin, 0.05-0.5 part of purslane extract, 0.5-5 parts of emulsifier, 0.05-0.3 part of preservative and 1-3 parts of humectant, wherein the balance is water according to 100 parts. The mosquito repellent liquid has the advantages of good mosquito repellent effect, itching relieving effect, safe and mild components, no stimulation to skin, and suitability for infants, children and pregnant women. The preparation method is simple and is beneficial to industrial production.

Description

Cool gel and preparation method thereof

Technical Field

The application relates to the technical field of skin care products, in particular to a cooling gel and a preparation method thereof.

Background

Mosquitoes are tiny winged insects with piercing-sucking mouthparts, which pierce the skin and suck blood as food. In summer, dryness-heat and excessive mosquitoes abuse cause pruritus and pain of human skin and influence sleeping due to mosquito bites, and in insect-bite dermatitis, dermatitis caused by mosquito bites is the most common. Saliva or venom invades the skin, and the saliva or venom of mosquitoes contains a plurality of antigen components, and the antigens can generate allergic reaction with antibodies to cause inflammation after entering the skin of a human body. Many insects causing dermatitis are bitten by insects, such as mosquitoes, bed bugs, fleas, mites, midges and the like are common, and other caterpillars such as mulberry caterpillars and spiny caterpillars have toxic burrs entering the skin to cause diseases. The most common is mite which is very small and ubiquitous in nature, so that the hidden danger of diseases and pests is difficult to completely eliminate.

In addition, the female mosquito that sucks blood is an intermediate host for pathogens such as dengue fever, malaria, yellow fever, filariasis, japanese encephalitis, etc., and is prone to transmit the disease during the bite.

The effective mosquito repelling components mainly comprise two kinds of deet and deet, and the chemical substances directly act on tactile organs and chemoreceptors of mosquitoes so as to repel the mosquitoes, so that the mosquito repelling effect is relatively obvious, but the mosquito repelling effect is relatively strong, the toxicity is not suitable for infants, children and pregnant women, and the environmental impact is relatively large.

Disclosure of Invention

The application aims to provide the cooling gel, which has a good mosquito repellent effect, also has an itching relieving effect, is safe and mild in components, has no stimulation to skin, and is suitable for infants, children and pregnant women.

Another objective of the present application is to provide a method for preparing a cooling gel, which is simple and is beneficial to industrial production.

The technical problem to be solved by the application is solved by adopting the following technical scheme.

On one hand, the embodiment of the application provides a cooling gel, which comprises the following raw materials in parts by weight: 3-6 parts of citronella oil, 1.5-3 parts of borneol, 0.05-0.5 part of golden chamomile extract, 0.01-1.0 part of eucalyptol, 0.03-0.2 part of lavender oil, 0.05-0.5 part of aloe extract, 0.1-0.2 part of chlorphenesin, 0.05-0.5 part of purslane extract, 5-10 parts of emulsifier, 0.05-0.3 part of preservative, 1-3 parts of humectant and 80-90 parts of water.

In another aspect, embodiments of the present application provide a method for preparing a cooling gel, which includes: step S1, adding an emulsifier, a humectant, a preservative, borneol, chlorphenesin and water into an emulsifying pot, dispersing uniformly, heating to 88-92 ℃, and stirring at constant temperature of 600-700r/min after the materials are melted;

step S2, cooling to 45-50 ℃, adding citronella oil, golden chamomile extract, eucalyptol, lavender oil, aloe extract, purslane extract and water, and stirring;

and step S3, cooling and discharging.

Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:

1. the application provides a cool and refreshing gel, through adding inferior citronella oil and eucalyptol, play the effect of mosquito repellent, golden yellow chamomile extract, lavender oil and aloe extract are in coordination with borneol, have the effect of disinfecting, antibacterial and relieving pain, the purslane extract can relieve itching, improve pain and red swelling, the aloe extract can promote wound healing, chlorphenesin can be in coordination with sterilization, the cooperation preservative result of use is better. The humectant can prevent skin from drying and peeling, and improve use feeling of the refreshing and cooling gel, and essential emulsifier is added to make various components such as water phase and oil phase stably mixed. The formula is mild in components, mainly adopts plant extracts, is safer and mild in components, is suitable for infants and pregnant women, has a good mosquito repelling effect, is fragrant in smell of the lavender oil, the lemongrass oil and the cineole, is slightly cool in skin feel, and can effectively relieve dryness-heat and discomfort in summer.

2. The application provides a preparation method of the cooling gel, which is simple to operate and beneficial to industrial production.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained from the drawings without inventive effort.

Fig. 1 is a diagram showing the mosquito repelling test result in experimental example 2 of the present application.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.

On one hand, the embodiment of the application provides a cooling gel, which comprises the following raw materials in parts by weight: 3-6 parts of citronella oil, 1.5-3 parts of borneol, 0.05-0.5 part of golden chamomile extract, 0.01-1.0 part of eucalyptol, 0.03-0.2 part of lavender oil, 0.05-0.5 part of aloe extract, 0.1-0.2 part of chlorphenesin, 0.05-0.5 part of purslane extract, 5-10 parts of emulsifier, 0.05-0.3 part of preservative and 1-3 parts of humectant, wherein the balance is water according to 100 parts.

The golden yellow chamomile extract has the effects of treating skin allergy, enhancing capillary resistance, relieving aging, whitening and removing freckles, and the flavonoid active ingredients in the golden yellow chamomile extract also have the effects of resisting oxidation, vascular proliferation, inflammation, allergy and virus.

Eucalyptol, also known as 1, 8-epoxy-p-menthane, is an organic compound which is colorless and transparent liquid, is insoluble in water, can be mixed and dissolved with ethanol, chloroform, glacial acetic acid, volatile oil or nonvolatile oil and the like, and is mainly used in cough drops and artificial mint. It has antibacterial, antiinflammatory, antioxidant, antifungal, anthelmintic, and mosquito repelling effects. In addition, pharmacological studies have shown that eucalyptol has analgesic and anti-inflammatory effects. When applied topically to the skin, it can help reduce muscle soreness, pain, swelling and inflammation.

The lavender oil is extracted from lavender, and has the skin care functions of clearing away heat and toxic materials, cleaning skin, controlling oil content, removing freckles, whitening skin, removing wrinkles, tendering skin, removing under-eye dark circles, promoting regeneration and recovery of damaged tissues and the like. The lavender essential oil also has a calming effect on heart, can reduce hypertension and soothe palpitation, and is helpful for insomnia. The antibacterial skin care agent has super-strong permeability, can quickly enter 240 microns below the skin to eradicate bacteria, thoroughly eliminates skin problems of whelk, acne, blackhead, large pore and the like caused by bacterial breeding and hair follicle blockage under the skin, and forms a gold protective film on the skin dermis layer to resist the secondary breeding of the bacteria. The product can be applied to wound caused by mosquito bite, and has effects of rapidly sterilizing and protecting skin.

Aloe vera extract is a colorless, transparent to brown, slightly viscous liquid that dries to a yellow fine powder. No smell or slightly peculiar smell. Has strong water replenishing performance. Aloe contains aloe-emodin, and has effect in resisting pathogenic microorganism. The aloe extract can promote regeneration and healing of injured tissues including X-ray burns, and has pharmacological effects of removing toxic substances, reducing blood lipid, resisting atherosclerosis, and promoting recovery of hematopoiesis function of experimental anemia. When acting on the wound bitten by mosquitoes, the aloe extract can effectively promote the wound healing and also has the functions of resisting bacteria and pathogenic microorganisms.

The herba Portulacae extract contains flavone and saponin, has effects of scavenging free radicals and resisting oxidation, and can be used for delaying skin aging. Pharmacological research shows that the purslane extract has obvious itching relieving function, obvious inhibition capacity on pain and red swelling, free radical elimination, skin comfort improvement and the like.

The cymbopogon citratus oil is a pure natural nontoxic substance which cannot kill mosquitoes, but the odor of the cymbopogon citratus oil can effectively dispel blood-sucking mosquitoes, ticks, fleas and the like. In addition, it also has antibacterial, antiinflammatory, muscles and tendons relaxing, collateral flow activating, and analgesic effects.

Borneolum, named as Borneolum, pericarpium Citri Tangerinae, folium Artemisiae Argyi, Borneolum Syntheticum, Serissa, Borneolum Syntheticum, and Borneolum Syntheticum, is prepared from stems and leaves of blumea balsamifera of Compositae or branches and leaves of Cinnamomum camphora of Lauraceae by steam distillation and recrystallization. Borneol has the effect of relieving pain for external application.

Chlorphenesin is used as a cosmetic bactericide in International cosmetic raw material dictionary and handbook in the cosmetic aspect, can effectively resist gram-positive and gram-negative bacteria, particularly has strong bactericidal activity on Aspergillus niger IMl149007 and Penicillium pinophilum IMI87160 (fungi), and has good inhibitory effect on Candida albicans NCPF3179 and Saccharomyces cerevisiae NCPF3275 (yeasts). In addition, it can be used as preservative to prevent various products from viscosity change, pH change, emulsion breaking, visible microbial growth, color change and generation of unpleasant odor, and has effect of prolonging shelf life of product by adding chlorphenesin into the cooling gel.

The preservative of the cosmetics refers to natural or synthetic components which are added into the cosmetics to prevent or delay the growth of microorganisms and prevent the cosmetics from rotting and deteriorating. Because of the wide variety of raw materials for cosmetics, water and various nutrients can provide a carbon source and a nitrogen source for the growth of microorganisms. In most cases, without preservatives, microorganisms will invade and multiply, causing turbidity, precipitation, foaming, color or taste changes in the cosmetic, and the emulsion will mildew, break, clump, causing spoilage of the product. The preservative is effective in prolonging the life of the product. Also, the prescribed amount of preservative is safe.

The main functions of the emulsifier are emulsification, dispersion, solubilization, foaming, cleaning, lubrication, softening and the like. The water phase and the oil phase which are not dissolved originally can be stably mixed together to form a milky product.

The humectant can be a common humectant, an emollient and a deep humectant according to the action mechanism. The general humectant is a substance with strong hygroscopicity, which is strongly combined with water to achieve the effect of keeping the stratum corneum warm, and is commonly used for glycerin, propylene glycol, sorbitol, lactic acid, pyrrolidone carboxylic acid, and the like; the emollient is an insoluble substance, forms a lubricating film on the skin surface, plays a role in sealing to prevent water from evaporating, so that water continuously diffuses from the inner layer of the skin into the stratum corneum to keep the stratum corneum at a certain water content, and is commonly used in vaseline, mineral oil and the like; deep moisturizers refer to substances that act by penetrating the epidermis or even the dermis of the skin by a series of biological actions that ultimately maintain and enhance the water absorption capacity and barrier function of the stratum corneum, maintaining the water content of the stratum corneum and preventing skin dryness.

In summary, the embodiments of the application have the effect of repelling mosquitoes by adding the citronella oil and the eucalyptol, the golden chamomile extract, the lavender oil and the aloe extract have the effects of sterilization, bacteriostasis and pain relief in cooperation with the borneol, the purslane extract can relieve itching and relieve pain and red swelling, the aloe extract can promote wound healing, the chlorphenesin can sterilize in cooperation, and the using effect of the composition in cooperation with the preservative is better. The humectant can prevent skin from drying and peeling, and improve use feeling of the refreshing and cooling gel, and essential emulsifier is added to make various components such as water phase and oil phase stably mixed. The formula is mild in components, mainly adopts plant extracts, is safer and mild in components, is suitable for infants and pregnant women, has a good mosquito repelling effect, is fragrant in smell of the lavender oil, the lemongrass oil and the cineole, is slightly cool in skin feel, and can effectively relieve dryness-heat and discomfort in summer.

It should be noted that the above citronella oil, 0.05-0.5 part of golden yellow chamomile extract, eucalyptol, lavender oil, 0.05-0.5 part of aloe extract and purslane extract can be extracted by the existing techniques, such as water extraction, ethanol extraction and recrystallization.

In some embodiments of the present application, the preservative is one or more of phenoxyethanol, ethylhexyl glycerol, and p-hydroxyacetophenone.

Phenoxyethanol is an organic compound that can be synthesized by etherification of ethylene glycol and phenol. The phenoxyethanol is low in toxicity, is a common preservative in cosmetics, belongs to one of relatively safe preservatives, and has the limited use concentration of 1 percent at most and 0.1 to 2 percent of solution in the cosmetics.

Ethylhexyl glycerin, also known as octoxyglycerin, is often added to cosmetics and skin care products, and belongs to a preservative in skin care products, and has little irritation to the skin. In addition, the ethylhexyl glycerin can also play a good antibacterial effect when added into the emulsion, and also has certain deodorization performance. The addition of the ethylhexyl glycerin can effectively inhibit the generation of peculiar smell in the water emulsion, thereby avoiding the continuous reproduction of bacteria, and the addition of the ethylhexyl glycerin in the skin care product also has the effect of prolonging the service life. It also has certain moisture keeping effect.

P-hydroxyacetophenone is white needle crystal at normal temperature, is flammable, is easily soluble in hot water, methanol, ethanol, ether, acetone and benzene, and is insoluble in petroleum ether. Is naturally present in stems and leaves of Artemisia scoparia of Compositae, and roots of Artemisia capillaris, Heteropappus japonica of Asclepiadaceae, etc. In cosmetics, it is used as a preservative.

In some embodiments of the present application, the preservative is a mixture of phenoxyethanol, ethylhexyl glycerol and p-hydroxyacetophenone in a mass ratio of (7-8): (0.5-1).

In the preservative, when the mass ratio of the phenoxyethanol to the ethylhexyl glycerol to the p-hydroxyacetophenone is (7-8) to (0.5-1), a better preservative effect can be achieved on the basis of controlling the using amount of the preservative, and the shelf life of the product is effectively prolonged.

In some embodiments herein, the humectant is a mixture of propylene glycol, butylene glycol, and glycerin.

Propylene glycol is a synthetic liquid substance that absorbs water. It is a viscous colorless liquid, almost tasteless, but with a light sweet taste. Contains two alcohol groups, which are classified as diols. It is miscible with a variety of solvents, including water, acetone and chloroform. Propylene glycol is generally non-irritating, has very low volatility and very low toxicity. The cosmetic has moisture keeping effect. Can also assist the penetration of cosmetic active ingredients into the skin.

The butanediol does not cause damage to skin after being used, and simultaneously, the environment for living bacteria is damaged, so that the moisturizing cream not only can preserve moisture, but also can control the skin to grow more bacteria. Because butanediol is a small molecular moisturizing component, the water-holding proportion is small. Butanediol is a few non-toxic chemical substances approved by the FDA in the united states. The butanediol is also used as a dissolving agent and a thickening agent, and the use feeling is more refreshing.

Glycerol, known under the name glycerol, is an infinitely water-miscible substance, such as ethanol (spirits). Glycerol has a characteristic of high water absorption (1 gram of glycerol can absorb 0.6 gram of water), so that glycerol can absorb water in the air to moisturize the skin and can lock the water in the skin to keep the water in the horny layer so as not to lose the water. Glycerol is a natural product, water-soluble, harmless to the skin, and non-toxic. It has strong compatibility, can be dissolved with a plurality of substances, has good mixing and oxidation resistance, and can be used as a base material, an emollient, a humectant, a lubricant and a solvent in various skin care products. Glycerol also has the functions of helping the skin heal, reducing the occurrence of related dermatitis, and restoring the normal barrier of the skin.

In some embodiments of the present application, the emulsifier is one or more of glyceryl caprylate, glyceryl laurate, and PEG-40 hydrogenated castor oil.

The glyceryl caprylate can be used as an emulsifier and a softener, has a risk coefficient of 1, is safe, can be used safely, and has no influence on pregnant women.

The glyceryl laurate is used as a softening agent and an emulsifier, has a risk coefficient of 1, is relatively safe, can be used safely, and has no influence on pregnant women. The glyceryl laurate can also be used as a fatting agent in surfactant washing and cleaning products, has the functions of moistening and conditioning, and can make the skin transparent and bright. Is mainly used for hair care and skin care formulas, and has the effects of moisturizing, moistening skin and moistening skin.

PEG-40 hydrogenated castor oil is used as emulsifier and surfactant, and has effects of lubricating and moisturizing. The content is below 1%, and the normal healthy skin usually does not feel irritation to the concentration.

In some embodiments of the present application, the emulsifier is a mixture of glyceryl caprylate, glyceryl laurate and PEG-40 hydrogenated castor oil in a mass ratio of (1-2) to (0.5-1) to (1-2).

When the emulsifier is a mixture of glyceryl caprylate, glyceryl laurate and PEG-40 hydrogenated castor oil, the mass ratio of the emulsifier is (1-2) to (0.5-1) to (1-2), the components in the formula can be effectively mixed at the temperature to form a milky product, and the components are safe and suitable for pregnant women.

In some embodiments of the present application, it comprises the following raw materials: 1 part of citronella oil, 1 part of borneol, 0.05 part of golden chamomile extract, 0.05 part of eucalyptol, 0.03 part of lavender oil, 0.05 part of aloe extract, 0.1 part of chlorphenesin, 0.05 part of purslane extract, 0.5 part of emulsifier, 0.05 part of preservative and 2 parts of humectant, wherein the balance is water according to 100 parts.

The various components are reasonably compounded to prepare the condensation, so that the condensation can repel mosquitoes, relieve itching and pain of wounds bitten by mosquitoes and insects, accelerate wound healing, has fresh texture, is slightly cool in skin when in use, and is suitable for being used in summer. The components are mild and safe, and are suitable for infants, children and pregnant women.

In another aspect, the present application provides a method for preparing a cooling gel, comprising:

step S1, adding an emulsifier, a humectant, a preservative, borneol, chlorphenesin and water into an emulsifying pot, dispersing uniformly, heating to 88-92 ℃, and stirring at constant temperature of 600-700r/min after the materials are melted;

and step S3, cooling and discharging.

According to the application, through simple operation, various components are mixed at a certain temperature, and then the components such as the citronella oil, the golden chamomile extract, the eucalyptol, the lavender oil, the aloe extract and the purslane extract are added after cooling, so that the active ingredients in the components can be effectively prevented from being inactivated or volatilized under a high-temperature condition, and the using effect of the cooling gel is retained to the greatest extent.

In some embodiments of the present application, the stirring time in step S1 is 25-30 min.

When the stirring time is 25-30min, the components can be stably mixed. Too short time can not achieve the effect, and too long time can waste time and reduce production efficiency.

In some embodiments of the present application, in the step S2, the rotation speed of the stirring is 500-600 r/min. Thus, the components can be stably mixed.

The features and properties of the present application are described in further detail below with reference to examples.

Examples

The raw materials were prepared in the following proportions (table 1).

TABLE 1 proportioning (g) of the raw materials in examples 1-4

The preparation method of example 1 is as follows: adding emulsifier, humectant, antiseptic, Borneolum Syntheticum, chlorphenesin and water into an emulsifying pot, dispersing uniformly, heating to 88 deg.C, melting, and stirring at 600r/min for 30 min; cooling to 45 deg.C, adding citronella oil, flos Matricariae Chamomillae extract, eucalyptol, oleum Lavandula Angustifolia, Aloe extract, herba Portulacae extract and water, stirring at 500 r/min; and (6) cooling and discharging. Wherein the preservative is a mixture of phenoxyethanol, ethylhexyl glycerol and p-hydroxyacetophenone in a mass ratio of 8:0.5: 0.5; the humectant is a mixture of propylene glycol, butanediol and glycerol, and the mass ratio of the humectant to the glycerol is 1:1: 2; the emulsifier is a mixture of glyceryl caprylate, glyceryl laurate and PEG-40 hydrogenated castor oil, and the mass ratio of the glyceryl caprylate to the glyceryl laurate to the PEG-40 hydrogenated castor oil is 2:1: 1.

The preparation method of the embodiment 2 comprises the following steps: adding emulsifier, humectant, antiseptic, Borneolum Syntheticum, chlorphenesin and water into an emulsifying pot, dispersing uniformly, heating to 92 deg.C, melting, stirring at 600-; cooling to 48 deg.C, adding citronella oil, flos Matricariae Chamomillae extract, eucalyptol, oleum Lavandula Angustifolia, Aloe extract, herba Portulacae extract and water, stirring at 550 r/min; and (6) cooling and discharging. Wherein the preservative is a mixture of phenoxyethanol, ethylhexyl glycerol and p-hydroxyacetophenone in a mass ratio of 7:1: 1; the humectant is a mixture of propylene glycol, butanediol and glycerol, and the mass ratio of the humectant to the glycerin is 1:1.5: 2; the emulsifier is a mixture of glyceryl caprylate, glyceryl laurate and PEG-40 hydrogenated castor oil, and the mass ratio of the glyceryl caprylate to the glyceryl laurate to the PEG-40 hydrogenated castor oil is 2:1: 2.

The preparation method of example 3 is as follows: adding emulsifier, humectant, antiseptic, Borneolum Syntheticum, chlorphenesin and water into an emulsifying pot, dispersing uniformly, heating to 90 deg.C, melting, and stirring at 650r/min for 28 min; cooling to 50 deg.C, adding citronella oil, flos Matricariae Chamomillae extract, eucalyptol, oleum Lavandula Angustifolia, Aloe extract, herba Portulacae extract and water, stirring at 600 r/min; and (6) cooling and discharging. Wherein the preservative is a mixture of phenoxyethanol, ethylhexyl glycerol and p-hydroxyacetophenone in a mass ratio of 7:0.5: 1; the humectant is a mixture of propylene glycol, butanediol and glycerol, and the mass ratio of the humectant to the glycerin is 1.5:1: 2; the emulsifier is a mixture of glyceryl caprylate, glyceryl laurate and PEG-40 hydrogenated castor oil, and the mass ratio of the glyceryl caprylate, the glyceryl laurate and the PEG-40 hydrogenated castor oil is 1.5:1: 2.

The preparation method of example 4 is as follows: adding emulsifier, humectant, antiseptic, Borneolum Syntheticum, chlorphenesin and water into an emulsifying pot, dispersing uniformly, heating to 90 deg.C, melting, and stirring at 650r/min for 28 min; cooling to 50 deg.C, adding citronella oil, flos Matricariae Chamomillae extract, eucalyptol, oleum Lavandula Angustifolia, Aloe extract, herba Portulacae extract and water, stirring at 600 r/min; and (6) cooling and discharging. Wherein the preservative is a mixture of phenoxyethanol and ethylhexyl glycerol in a mass ratio of 9: 1; the humectant is a mixture of propylene glycol, butanediol and glycerol, and the mass ratio of the humectant to the glycerin is 1.5:1: 2; the emulsifier is a mixture of glyceryl caprylate, glyceryl laurate and PEG-40 hydrogenated castor oil, and the mass ratio of the glyceryl caprylate, the glyceryl laurate and the PEG-40 hydrogenated castor oil is 1.5:1: 2.

Experimental example 1

The contents of harmful substances and microorganisms in examples 1 to 4 were measured according to the "cosmetic hygiene standards" (2015 edition), and the microorganism indicators were measured according to GB 15979 and tested by a third-party testing institution. The results are shown in tables 2 and 3 below.

TABLE 2 detection of harmful content

TABLE 3 microbiological indicator detection

Multiple integrity skin irritation experiments showed no or mild irritation.

As can be seen from tables 2 and 3, the cooling gels prepared in examples 1 to 4 are qualified in each index, substantially free of irritation to the skin and high in safety.

Experimental example 2

Selecting 5 or more healthy volunteers, and bringing the healthy volunteers into the standard: (1) age 18-40 years; (2) no cosmetic or pharmaceutical allergy history; (3) no history of any skin or systemic disease; (4) those without constitutional hypersensitivity; (5) the tested part did not participate in other clinical testers in the last three months; (6) voluntarily participate in the study, and read the informed consent, and can strictly comply with the requirements of the study scheme.

Repelling test: selecting Aedes albopictus and 5 or more testers with acceptable offensive power, marking the skin of the testers with 5cm × 5cm, and uniformly applying the cool gel (1.5 mg/cm) on the back of the hand ² ) The back of the hand is covered with a material such as a glove, and only 4cm × 4cm of skin coated with the gel is exposed, and the other hand is applied with a commercial toilet water. After 2h, the gel-coated hand was inserted into a mosquito cage for 2min and observedWhether mosquitoes stop and suck blood or not. And then testing every 1h, judging that the tested object is invalid as long as one mosquito stops and sucks blood during the testing period, and recording the effective protection time (h). Before each test, the reference hand is required to perform the test first, when the attack force of the mosquitoes is qualified, the test can be continuously performed, otherwise, the mosquitoes with qualified attack force are replaced to continuously perform the test.

Calculating the effective protection time: the average number of effective protection times of the test person was taken.

Examples 1-4 were tested in at least 5 volunteers per group, with a control of commercially available toilet water, and the results are shown in FIG. 1.

As can be seen from fig. 1, the mosquito repellent effects of the cooling gels provided in examples 1 to 4 are slightly better than those of the mosquito repellent toilet water (containing 12.5% of anophelifuge ester) sold in the market, but no obvious difference exists, and the cooling gels provided in examples 1 to 4 of the present application can achieve better mosquito repellent effects, but do not contain anophelifuge ester, have safer components, and are suitable for infants, children and pregnant women. Wherein, the higher the content of the cedronella oil. The mosquito repellent effect tends to be increased.

In summary, the cooling gel provided by the embodiment of the application has the advantages that the effect of repelling mosquitoes is achieved by adding the citronella oil and the eucalyptol, the golden chamomile extract, the lavender oil and the aloe extract are cooperated with the borneol, the effects of sterilization, bacteriostasis and pain relieving are achieved, the purslane extract can relieve itching and relieve pain and red swelling, the aloe extract can promote wound healing, the chlorphenesin can be cooperatively sterilized, and the using effect of the cooling gel matched with the preservative is better. The humectant can prevent skin from drying and peeling, and improve use feeling of the refreshing and cooling gel, and essential emulsifier is added to make various components such as water phase and oil phase stably mixed. The formula is mild in components, mainly adopts plant extracts, is safer and mild in components, is suitable for infants and pregnant women, has a good mosquito repelling effect, is fragrant in smell of the lavender oil, the lemongrass oil and the cineole, is slightly cool in skin feel, and can effectively relieve dryness-heat and discomfort in summer.

The application also provides a preparation method of the cooling gel, and the cooling gel is prepared by mixing various components at different temperatures through simple operation, adding the components such as the citronella oil, the golden chamomile extract, the eucalyptol, the lavender oil, the aloe extract and the purslane extract after cooling, and can effectively prevent the active ingredients in the cooling gel from being inactivated or volatilized under the high-temperature condition, so that the using effect of the cooling gel is kept to the maximum extent.

The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Claims

1. The cooling gel is characterized by comprising the following raw materials in parts by weight: 3-6 parts of citronella oil, 1.5-3 parts of borneol, 0.05-0.5 part of golden chamomile extract, 0.01-1.0 part of eucalyptol, 0.03-0.2 part of lavender oil, 0.05-0.5 part of aloe extract, 0.1-0.2 part of chlorphenesin, 0.05-0.5 part of purslane extract, 0.5-5 parts of emulsifier, 0.05-0.3 part of preservative and 1-3 parts of humectant, wherein the balance is water according to 100 parts.

2. The cooling gel of claim 1, wherein the preservative is one or more of phenoxyethanol, ethylhexyl glycerol, and p-hydroxyacetophenone.

3. The cooling gel of claim 2, wherein the preservative is a mixture of phenoxyethanol, ethylhexyl glycerol and p-hydroxyacetophenone in a mass ratio of (7-8): (0.5-1).

4. The cooling gel of claim 1, wherein the humectant is a mixture of propylene glycol, butylene glycol and glycerin.

5. The cooling gel of claim 1, wherein the emulsifier is one or more of caprylic acid glyceride, lauric acid glyceride and PEG-40 hydrogenated castor oil.

6. The cooling gel of claim 5, wherein the emulsifier is a mixture of glyceryl caprylate, glyceryl laurate and PEG-40 hydrogenated castor oil in a mass ratio of (1-2): (0.5-1): (1-2).

7. A cooling gel according to claim 1, characterized in that it comprises the following raw materials: 3 parts of citronella oil, 1.5 parts of borneol, 0.05 part of golden chamomile extract, 0.05 part of eucalyptol, 0.03 part of lavender oil, 0.05 part of aloe extract, 0.1 part of chlorphenesin, 0.05 part of purslane extract, 0.5 part of emulsifier, 0.05 part of preservative and 2 parts of humectant, wherein the balance is water according to 100 parts.

8. A method for preparing a cooling gel as claimed in any one of claims 1 to 7, which comprises:

and step S3, cooling and discharging.

9. The method for preparing a cooling gel according to claim 8, wherein in the step S1, the stirring time is 25-30 min.

10. The method for preparing a cooling gel according to claim 8, wherein in step S2, the rotation speed of stirring is 500-600 r/min.