CN1895632A - Compound turmeric acne-eliminating gel and its preparation - Google Patents
Compound turmeric acne-eliminating gel and its preparation Download PDFInfo
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- CN1895632A CN1895632A CN 200610051098 CN200610051098A CN1895632A CN 1895632 A CN1895632 A CN 1895632A CN 200610051098 CN200610051098 CN 200610051098 CN 200610051098 A CN200610051098 A CN 200610051098A CN 1895632 A CN1895632 A CN 1895632A
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Abstract
A Chinese medicine in the form of gel for treating acne and fungal dermatopathy is prepared from 7 Chinese-medicinal materials including turmeric, Paris polyphylla, mexican tea herb, gynostemma pentaphyllum, etc and 5 auxiliaries including carbomer, glycerin, triethanolamine, hydroxyphenyl ethylester and distilled water. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of acne,, relate to the preparation method of this gel simultaneously in particular to being the exterior-applied gel of preparation of raw material with Chinese medicine substantially.
Background technology
Acne is commonly called as acne, comedo, is the common skin disease, and the faces of giving birth in adolescence mainly because endocrine is vigorous, sebum is too much, bacterial infection causes more.The normally conical little pimple of acne, can influence the people appearance, cause serious mental pressure, patient's physical and mental health is all had infringement.People are when improving material and cultural life, and also wishing has beautiful appearance, how to treat the content that acne has just become doctors to study.For example Chinese patent application No. 95113710.7 " face-nurishing acne-diminishing capsule ", 98114618.x number " Chinese medicine liquid for eliminating acne and skin care ", No. 93115910.5 " acne Herba Senecionis Dianthui prescription and compound method ", No. 94106098.5 " preparation method of Chinese medicine face mask for treating acne and purposes ", No. 97108499.8 " Chinese medicine buauty liquid capable of eliminating acne and whitening skin ", No. 98111997.2 " skin nursing cream for curing comedo " and No. 200510003033.2 " a kind of liniment for the treatment of acne and preparation method thereof " disclose the medicine of some treatment acnes respectively, and these curative effect of medication are unclear.But people are still exploring and are studying renewal, more efficient drug.
Summary of the invention
Purpose of the present invention just be to provide a kind of basic employing Chinese medicine preparation, be used for treating the compound turmeric acne-eliminating gel that acne and some skin take a disease, patient Lai Zhi is fully recovered.
Another object of the present invention provides the preparation method of this gel.
Compound turmeric acne-eliminating gel of the present invention is formulated by principal agent and adjuvant.
The principal agent component and the consumption thereof of every 1000g compound turmeric acne-eliminating gel are as follows:
Rhizoma Curcumae Longae 30～65g Rhizoma Paridis 40～60g Herba Polygoni Perfoliati 40～60g Herba Solidaginis 20～40g
Herba Chenopodii 20～40g Herb Gynostemmae Pentaphylli 20～60g Rhizoma Zingiberis corallini 30～65g;
The adjuvant component and the consumption thereof of every 1000g gel are as follows:
Carbomer 15g, glycerol 100g, triethanolamine 15g, ethyl hydroxybenzoate 2g, distilled water 500ml.
In the above-mentioned gel principal agent, (Curcuma longa) is warm in nature for Rhizoma Curcumae Longae, the acrid in the mouth hardship, removing blood stasis, circulation of qi promoting arranged, stimulate the menstrual flow, the analgesic effect, can control carbuncle, that the turmerone in its volatile oil has is antibiotic, antiinflammatory, antipruritic, analgesic effect (see the new medical college in Jiangsu compile " Chinese medicine voluminous dictionary " 1735 pages); Rhizoma Paridis (Paris petiolata) mildly bitter flavor, fiber crops have heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion effect, are used to control the swollen carbuncle (seeing " Chinese medicine voluminous dictionary " 1687 pages) of furuncle; Herba Polygoni Perfoliati (Polygonum parfoliatum) property is flat, sour in the mouth hardship, energy inducing diuresis to remove edema, heat clearing away, invigorate blood circulation, detoxify (seeing " Chinese medicine voluminous dictionary " 869 pages); (Solidago virga-aurea) is cool in nature for Herba Solidaginis, acrid in the mouth hardship, energy wind and heat dispersing, subduing swelling and detoxicating (seeing " Chinese medicine voluminous dictionary " 8 pages); (Chenopodium ambrosioides) is warm in nature for Herba Chenopodii, acrid in the mouth, can dispel the wind, parasite killing, stimulate the menstrual flow, pain relieving (seeing " Chinese medicine voluminous dictionary " 90 pages); (Gynostemmaambrosioides) is cold in nature for Herb Gynostemmae Pentaphylli, bitter in the mouth, energy anti-inflammatory analgetic (seeing " Chinese medicine voluminous dictionary " 16 pages); Rhizoma Zingiberis corallini (Rhizoma zingibel) acrid in the mouth is peppery, can heat-clearing and toxic substances removing, detumescence (see " Chinese Plants will) " 143 pages in 16 volumes, 2 fascicles), its volatile oil contains terpinene-4 alcohol, can be antibiotic, antifungal, especially can the anti-acne propionibacterium.
In the above-mentioned gel adjuvant, carbomer is the matrix components of gel, and stable and dispersive effect are arranged; Glycerol has the skin moistening effect, and triethanolamine has the effect of regulating pH value; Ethyl hydroxybenzoate plays antisepsis; Distilled water is a solvent.
In above-mentioned principal agent composition, used Rhizoma Curcumae Longae and Rhizoma Zingiberis corallini are the volatile oil that extracts them, and used Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are their percolates; Used Herba Polygoni Perfoliati, Herba Chenopodii are their water extract-alcohol precipitation liquid.
Rhizoma Curcumae Longae used in the present invention's prescription is because of place of production difference, and Rhizoma Zingiberis corallini is because of the extracting method difference, and the volatile oil active constituent content has certain discrepancy, differs 2%～8% usually; But require that wherein turmerone content is greater than 20%, the pure content of terpinene-4 is greater than 30%, and the high more curative effect of content is good more.
The preparation method of compound turmeric acne-eliminating gel of the present invention comprises:
(1) get Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini, through selection, cleaning, drying is 8 hours under 60 ℃, takes by weighing Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini by formula proportion, and pulverize separately becomes coarse powder, crosses 20 mesh sieves, extracts volatile oil respectively with vapor distillation, and is standby;
(2) get Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis, through selection, cleaning, drying is 8 hours under 60 ℃, gets Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis by formula proportion, is ground into fine powder, cross 60 mesh sieves, according to " percolation under Chinese pharmacopoeia middle fluid extract of version in 2000 and the extractum item is done solvent impregnated 36 hours with 80% ethanol of 6 times of amounts, with the speed of per minute 1～3ml percolation slowly, collect percolate, standby;
(3) get Herba Polygoni Perfoliati, Herba Chenopodii, through selection, cleaning, drying is 8 hours under 60 ℃, gets Herba Polygoni Perfoliati, Herba Chenopodii by formula proportion again, decocts with water 3 times: boiled 2 hours with 10 times of decoctings for the first time, obtain the water extract; Medicinal residues boiled 1.5 hours with 8 times of decoctings for the second time, obtained the water extract; Medicinal residues boiled 1 hour with 6 times of decoctings for the third time, obtained the water extract; Merge 3 times and obtain the water extract, filter, filtrate is concentrated into the clear paste of relative density 1.20～1.22 (60 ℃), adds ethanol and reaches 50% to containing the alcohol amount, leaves standstill 24 hours, and it is standby to obtain alcohol deposit fluid, and pure sediment discards;
(4) percolate and the alcohol deposit fluid in the 3rd step with second step merges, and is concentrated into the clear paste of relative density 1.20～1.25 (60 ℃) behind the recovery ethanol, and be standby;
(5) take by weighing carbomer in proportion, pour in the glycerol, fully stir, make carbomer fully moistening after, add an amount of distilled water and stir, treat that the carbomer swelling adds triethanolamine, ethyl hydroxybenzoate and distilled water in the back fully, the limit edged stirs and makes into gel.
(6) above volatile oil and clear paste are added in the gel, emulsifying, fill promptly get compound turmeric acne-eliminating gel of the present invention.
The usage of compound turmeric acne-eliminating gel of the present invention is: with the direct spot printing affected part of gel, medicinal liquid infiltration back repaste is repeatedly about 10 times, till acne disappears.
Compound turmeric acne-eliminating gel of the present invention is mainly used in the treatment acne, and curative effect is obvious; This medicine also can be used for treating dermatomycosis, herpesvirus dermatosis and itching skin disease simultaneously, and remarkable therapeutic effect is arranged.
Compound turmeric acne-eliminating gel of the present invention proves in Clinical Application, adopts this gel can cure acne and dermatomycosis, herpesvirus dermatosis and itching skin disease fully, and that this gel prepares is easy, curative effect is desirable, carries with easy to use.According to statistics, the result is as follows: to acne vulgaris, the evenly remarkable therapeutic effect of cyst nodular type acne, cure rate reaches 98%; Tinea corporis and cruris is all cured in 2 weeks, and antipruritic effect is obvious, and skin lesion disappears.Concrete clinical practice situation such as following table:
| The skin kind that takes a disease | Case load | Cure number | Cure rate (%) |
| Acne vulgaris cyst nodular type acne tinea corporis and cruris herpes zoster | 300 130 200 200 | Cured in 284 120 198 5～15 days | 98 80 99 |
The specific embodiment
Embodiment prepares compound turmeric acne-eliminating gel of the present invention according to the following step:
(1)) get Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini, through selection, cleaning, drying is 8 hours under 60 ℃, takes by weighing Rhizoma Curcumae Longae, each 50g of Rhizoma Zingiberis corallini by prescription, and pulverize separately becomes coarse powder, crosses 20 mesh sieves, extracts volatile oil respectively with vapor distillation, and is standby;
(2) get Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis, through selection, cleaning, drying is 8 hours under 60 ℃, takes by weighing Herb Gynostemmae Pentaphylli 25g, Herba Solidaginis 25g, Rhizoma Paridis 50g afterwards, is ground into fine powder, cross 60 mesh sieves, according to " percolation under Chinese pharmacopoeia middle fluid extract of version in 2000 and the extractum item is done solvent impregnated 36 hours with 80% ethanol of 6 times of amounts, with the speed of per minute 1～3ml percolation slowly, collect percolate, standby;
(3) get Herba Polygoni Perfoliati, Herba Chenopodii, through selection, cleaning, drying is 8 hours under 60 ℃, takes by weighing Herba Polygoni Perfoliati 50g, Herba Chenopodii 25g again, merges to decoct with water 3 times: boiled 2 hours with 10 times of decoctings for the first time, obtain the water extract; Medicinal residues boiled 1.5 hours with 8 times of decoctings for the second time, obtained the water extract; Medicinal residues boiled 1 hour with 6 times of decoctings for the third time, obtained the water extract; Merge 3 times and obtain the water extract, filter, filtrate is concentrated into the clear paste of relative density 1.20～1.22 (60 ℃), adds ethanol and reaches 50% to containing the alcohol amount, leaves standstill 24 hours, and it is standby to obtain alcohol deposit fluid, and pure sediment discards;
(4) percolate and the alcohol deposit fluid in the 3rd step with second step merges, and is concentrated into the clear paste of relative density 1.20～1.25 (60 ℃) behind the recovery ethanol, and be standby;
(5) take by weighing carbomer 15g, pour in the 100g glycerol, fully stir, make carbomer fully moistening after, add an amount of distilled water and stir, treat that the carbomer swelling adds triethanolamine 15g, ethyl hydroxybenzoate 2g and distilled water in the back fully, the limit edged stirs and makes into gel.
(6) above volatile oil and clear paste are added in the gel, emulsifying, fill promptly get compound turmeric acne-eliminating gel of the present invention.
Claims (4)
1 one kinds of compound turmeric acne-eliminating gels, formulated by principal agent and adjuvant, it is characterized in that the principal agent component and the consumption thereof of every 1000g compound turmeric acne-eliminating gel is as follows:
Rhizoma Curcumae Longae 30～65g Rhizoma Paridis 40～60g Herba Polygoni Perfoliati 40～60g Herba Solidaginis 20～40g
Herba Chenopodii 20～40g Herb Gynostemmae Pentaphylli 20～60g Rhizoma Zingiberis corallini 30～65g;
The adjuvant component and the consumption thereof of every 1000g gel are as follows:
Carbomer 15g, glycerol 100g, triethanolamine 15g, ethyl hydroxybenzoate 2g, distilled water 500ml.
2 according to the described compound turmeric acne-eliminating gel of claim 1, it is characterized in that in the described principal agent composition, and used Rhizoma Curcumae Longae and Rhizoma Zingiberis corallini are the volatile oil that extracts with them, and used Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis are their percolates; Used Herba Polygoni Perfoliati, Herba Chenopodii are their alcohol deposit fluid.
3 according to the described compound turmeric acne-eliminating gel of claim 2, it is characterized in that used Rhizoma Curcumae Longae volatile oil effective ingredient turmerone content greater than 20%, and the pure content of Zingiber corallinum Hance volatil oil effective ingredient terpinene-4 is greater than 30%.
4 compound methods according to the described compound turmeric acne-eliminating gel of claim 1, its feature comprises:
(1) get Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini, through selection, cleaning, drying is 8 hours under 60 ℃, takes by weighing Rhizoma Curcumae Longae, Rhizoma Zingiberis corallini by formula proportion, and pulverize separately becomes coarse powder, crosses 20 mesh sieves, extracts volatile oil respectively with vapor distillation, and is standby;
(2) get Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis, through selection, cleaning, drying is 8 hours under 60 ℃, gets Herb Gynostemmae Pentaphylli, Herba Solidaginis, Rhizoma Paridis by formula proportion, is ground into fine powder, cross 60 mesh sieves, according to " percolation under Chinese pharmacopoeia middle fluid extract of version in 2000 and the extractum item is done solvent impregnated 36 hours with 80% ethanol of 6 times of amounts, with the speed of per minute 1～3ml percolation slowly, collect percolate, standby;
(3) get Herba Polygoni Perfoliati, Herba Chenopodii, through selection, cleaning, drying is 8 hours under 60 ℃, gets Herba Polygoni Perfoliati, Herba Chenopodii by formula proportion again, decocts with water 3 times: boiled 2 hours with 10 times of decoctings for the first time, obtain the water extract; Medicinal residues boiled 1.5 hours with 8 times of decoctings for the second time, obtained the water extract; Medicinal residues boiled 1 hour with 6 times of decoctings for the third time, obtained the water extract; Merge 3 times and obtain the water extract, filter, filtrate is concentrated into the clear paste of relative density 1.20～1.22 (60 ℃), adds ethanol and reaches 50% to containing the alcohol amount, leaves standstill 24 hours, and it is standby to obtain alcohol deposit fluid, and pure sediment discards;
(4) percolate and the alcohol deposit fluid in the 3rd step with second step merges, and is concentrated into the clear paste of relative density 1.20～1.25 (60 ℃) behind the recovery ethanol, and be standby;
(5) take by weighing carbomer in proportion, pour in the glycerol, fully stir, make carbomer fully moistening after, add an amount of distilled water and stir, treat that the carbomer swelling adds triethanolamine, ethyl hydroxybenzoate and distilled water in the back fully, the limit edged stirs and makes into gel.
(6) above volatile oil and clear paste are added in the gel, emulsifying, fill promptly get compound turmeric acne-eliminating gel of the present invention.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100510989A CN100563629C (en) | 2006-06-15 | 2006-06-15 | Compound turmeric acne-eliminating gel and preparation method thereof |
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| CNB2006100510989A CN100563629C (en) | 2006-06-15 | 2006-06-15 | Compound turmeric acne-eliminating gel and preparation method thereof |
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| CN100563629C CN100563629C (en) | 2009-12-02 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520328A (en) * | 2013-10-31 | 2014-01-22 | 天津中医药大学 | Compound traditional Chinese medicine acne gel and preparation method thereof |
| CN104940887A (en) * | 2015-07-20 | 2015-09-30 | 任明 | Application of drug combination |
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- 2006-06-15 CN CNB2006100510989A patent/CN100563629C/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520328A (en) * | 2013-10-31 | 2014-01-22 | 天津中医药大学 | Compound traditional Chinese medicine acne gel and preparation method thereof |
| CN104940887A (en) * | 2015-07-20 | 2015-09-30 | 任明 | Application of drug combination |
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| CN100563629C (en) | 2009-12-02 |
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Address after: 550004 Guizhou City, Guiyang Province in the large area of the slope of the slope of the Middle East International A1 business building, layer 10, No. 19 Patentee after: Guizhou Shuangsheng Pharmaceutical Co. Ltd. Address before: 550002 Ruijin Middle Road, Guizhou, No. 69 purple Lin Garden Patentee before: Shumeida Pharmaceutical Factory Co., Ltd., Guiyang |
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Address after: 551400 high tech industry planning area, Qingzhen City, Guiyang City, Guizhou Province Patentee after: Mingyuan Pharmaceutical Co.,Ltd. Address before: 550004 No. 10, 19th floor, Zhongda international A1 business building, dayingpo, Yunyan District, Guiyang City, Guizhou Province Patentee before: GUIZHOU SHUANGSHENG PHARMACEUTICAL Co.,Ltd. |