CN102755572B - Medicine for external application for treating eczema disease and preparation method thereof - Google Patents
Medicine for external application for treating eczema disease and preparation method thereof Download PDFInfo
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Abstract
The invention provides medicine for external application for treating the eczema disease and a preparation method thereof. The preparation method includes respectively immersing rhizoma smilacis glabrae, fructus forsythiae, schizonepeta, folium artemisiae argyi, mirabilite, garden balsam stem, liquorice, pepper traditional Chinese medicine into rice vinegar which is boiled and cooled, then revaccinating acetobacter aceti (Acetobactersp.) GLYSM66 CCTCC M2011238, conducting fermentation in different time and blending fermentation liquid to prepare the medicine. The medicine for external application has the strong functions of promoting blood circulation, removing blood stasis, relaxing tendons, activating muscles and joints, expelling wind, removing dampness, promoting circulation of qi, diminishing inflammation and relieving pain and itch. The medicine for external application is remarkable in eczema treating effect, low in treating cost and simple in preparation method.
Description
Technical field
The present invention relates to application compress, specifically a kind of application compress for the treatment of eczema and preparation method thereof.
Background technology
Eczema is the scytitis that is caused by multiple internal and external factor, different according to eczema position symptom, can be divided into legs eczema, eczema scrotum, breast eczema or hand eczema etc., at present many employing 0.25% Procaine injection 10～20ml vitaminize C 500mg intravenous injection is embrocated the affected part to the many employings of the tinea medicine antipruritic, sterilization of locality.The chronic limitation eczema long and obstinate for stadium adopts physics and X-ray therapy, liquid nitrogen cryotherapy, superficial X-ray or radionuclide (32P or 90Sr) plastering therapy, and medical expense is high, and side effect is large.
Because the processing procedure of most of Chinese medicines is by boiling, the method for the effective ingredient in the Chinese crude drug with decocting in water being extracted.But this method has following shortcoming: 1, owing to boil time, temperature, pressure and can not unify, the effective ingredient in the Chinese crude drug is difficult to be extracted fully; 2, it is very high to boil in the process temperature, might destroy the effective ingredient of those heat sensitivitys; 3, be the intermediate of effective ingredient mostly by boiling merely the Chinese medicine ingredients that lixiviate goes out, must transform by the probiotic bacteria in human body, finally become the effective ingredient that works, enter blood, because human body probiotic bacteria situation is different, thereby produce the situation such as slow or ineffective that takes effect, therapeutic effect is unsatisfactory, and the exploitation low toxicity, the antieczematic new drug is the vital task of diseases prevention and treatment efficiently.
Summary of the invention
For the deficiencies in the prior art, the invention provides application compress of a kind for the treatment of eczema that can nurse one's health dredging the meridian, antipruritic fast, good effect, have no side effect again and preparation method thereof.
The technical scheme that realizes the object of the invention is:
A kind of application compress for the treatment of eczema, it is to be immersed in respectively in the rice vinegar through boiling cooling by Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli Chinese crude drug, inoculate acetobacter, when different fermentations, behind the indirect fermentation, its fermentation liquid is blent made again.
Described acetobacter is acetobacter (Acetobacter sp.) GLYSM66 CCTCC NO:M2011238, be called for short acetobacter GLYSM66, that the inventor screens from common acetobacter, (be called for short: CCTCC), deposit number is CCTCC NO:M2011238 to be deposited in Wuhan University Chinese Typical Representative culture collection center on July 5th, 2011.This acetobacter has the function of degraded several kinds of Chinese medicinal materials or composite Chinese crude drug.
The preparation method of application compress of the present invention comprises the steps:
(1) Chinese crude drug Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli were pulverized respectively 100 orders, and autoclaving 30 minutes, for subsequent use;
(2) rice vinegar is boiled with warm fire, naturally cool to room temperature, for subsequent use;
(3) 8 kinds of Chinese crude drugs step (1) being processed are immersed in respectively in the rice vinegar after step (2) sterilization, and solid-liquid ratio is 1 ︰ (8-10);
(4) with acetobacter GLYSM66 with LB culture medium amplification culture after, be inoculated into respectively in each medical material soak, its inoculum concentration is: medical material soaks the ︰ 1 of the volume ratio of Ye ︰ strain=(20-50);
(5) ferment at normal temperatures, fermentation time is respectively: Rhizoma Smilacis Glabrae 85-95 days; Fructus Forsythiae 85-95 days; Herba Schizonepetae 85-95 days; Folium Artemisiae Argyi 85-95 days; Mirabilitum 145-155 days; Herba speranskiae tuberculatae 85-95 days; Radix Glycyrrhizae 85-95 days; Pericarpium Zanthoxyli 145-155 days;
(6) blend: get each medicine fermentation liquid and blend, its weight part ratio is: native Fu Siberian cocklebur ︰ connects and sticks up ︰ chaste tree mustard ︰ Ai Ye ︰ Piao ︰ (2-4) ︰ (5-7) ︰ (4-6) ︰ (9-11) ︰ (5-7) ︰ (2-4) ︰ (0.8-2) of the sweet careless ︰ Pericarpium Zanthoxyli of the saturating bone grass ︰ of ︰=(2-4) that disappears;
(7) seal up for safekeeping again after blending more than 3 months.
The using method of this medicine has two kinds, can be with wherein a kind of, and also can two kinds of combinations:
First method is:
(1) take a shower first, patient's pore is fully opened after, with this medicinal liquid fumigation 30 minutes to 1 hour;
(2) put on the clothes that soaked with this medicinal liquid, the parcel health;
(3) toast whole body with infrared ray;
(4) carry out channels and network vessels regulation.
10 days is a course for the treatment of.
Second method is: external application, suction medicinal liquid with absorbent paper, and apply at the eczema happening part, the external preservative film encases, and fixes with adhesive tape, and applied 6 hours every day at least, and 7 days is a course for the treatment of.
The record of the pharmacological action of each medical material certificate " Chinese medicine voluminous dictionary " and books such as " national Chinese herbal medicine compilations " in these application compress: Rhizoma Smilacis Glabrae is root, the stem of liliaceous plant Rhizoma Smilacis Glabrae, has detoxifcation, dehumidifying, sharp joint; Fructus Forsythiae is the fruit of Oleaceae plants Fructus Forsythiae, has heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Herba Schizonepetae is the herb of labiate Herba Schizonepetae, has the loose wind that induces sweat, rash; Folium Artemisiae Argyi is the dried leaves of feverfew Chinese mugwort, tool dispersing cold for relieving pain, warming the meridian for stopping bleeding; Mirabilitum is the rough crystallization that the mineral Natrii Sulfas gets through processing, tool clearing heat for detumescence, hard masses softening and resolving; Herba speranskiae tuberculatae has another name called Herba Viciae Amoenae, is stem, the leaf of ericad Yunnan Gaultheria, tool wind-damp dispelling, relaxing muscles and tendons to promote blood circulation, pain relieving; The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; The Pericarpium Zanthoxyli warming middle-JIAO ends, killing parasites for relieving itching; These Chinese crude drugs are after acetobacter fermentation of the present invention, make the Chinese crude drug decomposition and inversion, effective ingredient is discharged fully, strengthened the property of medicine, while acetobacter strong acid environment, strengthen the non-oxidizability of effective ingredient, had stronger blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, the dehumidifying of Eradicates wind, circulation of qi promoting anti-inflammatory analgetic, antipruritic function.Treatment eczema effect is remarkable, and medical expense is low, and preparation method is simple.
Clinical this medicine of usefulness treatment eczema 6 examples are wherein cured 3 examples fully, significant curative effect 3 examples, and to skin non-stimulated and toxic and side effects.
The specific embodiment
The present invention is described by the following examples.
Used acetobacter GLYSM66 obtains by the screening technique that comprises the steps in the present embodiment:
(1) gets Flos Galinsogae Parviflorae, Semen Fagopyri Esculenti root, very heavy group, YIDUOYUN or five kinds of Chinese crude drugs of Rhizoma Paridis, pulverize, cross 100 mesh sieves, autoclaving 30 minutes respectively afterwards, five kinds of Chinese crude drug mixed in equal amounts or deposit separately for subsequent use;
(2) use the soaking in rice vinegar medical material, the mass volume ratio (Gong Jin ︰ liter of medical material and rice vinegar) 1 ︰ (5-10), soaking temperature 20-35 ℃, the time that soaking fermentation is different;
(3) get the fermentation liquid of different fermentations time, measure effective ingredient--total flavones and total saponins, simultaneously through 1000 power microscope microscopies, total flavones and total saponin content in the sample that relatively sample of five kinds of Chinese crude drug mixed in equal amounts and five kinds of Chinese crude drugs are single, found that: biased sample is total flavones and total saponin content height not only, and only has single microorganism in the fermentation liquid; Microbe species in latter's liquid is many.Separation screening is carried out in microorganism to biased sample, and successive transfer culture obtains the acetobacter of the several kinds of Chinese medicinal materials of degrading of the present invention.
The used LB culture medium of the amplification culture of acetobacter described in the present embodiment is by sodium chloride 10g, and peptone 10g, yeast extract 5g add water and be settled to 1L and make.
Embodiment 1
A kind of preparation method for the treatment of the application compress of eczema comprises the steps:
(1) Chinese crude drug Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli were pulverized respectively 100 orders, and autoclaving 30 minutes, for subsequent use;
(2) rice vinegar is boiled with warm fire, naturally cool to room temperature, for subsequent use;
(3) 8 kinds of Chinese crude drugs step (1) being handled well are immersed in respectively in the rice vinegar after step (2) sterilization, and solid-liquid ratio is 1 ︰ (8-10);
(4) with acetobacter GLYSM66 with LB culture medium amplification culture after, be inoculated into respectively in each medical material soak, its inoculum concentration is: medical material soaks the ︰ 1 of the volume ratio of Ye ︰ strain=(20-50);
(5) ferment at normal temperatures, fermentation time is respectively: Rhizoma Smilacis Glabrae 90 days; Fructus Forsythiae 90 days; Herba Schizonepetae 90 days; Folium Artemisiae Argyi 90 days; Mirabilitum 150 days; Herba speranskiae tuberculatae 90 days; Radix Glycyrrhizae 90 days; Pericarpium Zanthoxyli 150 days;
(6) blend: the weight part ratio (kilogram) that each medicine fermentation liquid is blent is: native Fu Siberian cocklebur ︰ connects and sticks up the ︰ chaste tree mustard ︰ Ai Ye ︰ Piao sweet careless ︰ Pericarpium Zanthoxyli of the saturating bone grass ︰ of ︰=3 ︰, 3 ︰, 6 ︰, 5 ︰, 10 ︰, 6 ︰, 3 ︰ 1 that disappear;
(7) seal up for safekeeping again after blending and namely made Compound Chinese Herbs for Fatigue-Resistance of Animal in 90 days.
Embodiment 2
Method step according to embodiment 1 carries out, different is: the weight part ratio (kilogram) that described each the medicine fermentation liquid of step (6) is blent is: native Fu Siberian cocklebur ︰ connects and sticks up the ︰ chaste tree mustard ︰ Ai Ye ︰ Piao sweet careless ︰ Pericarpium Zanthoxyli of the saturating bone grass ︰ of ︰=2.5 ︰, 2.5 ︰, 5.5 ︰, 4.5 ︰, 9.5 ︰, 5.5 ︰, 2.5 ︰ 0.8 that disappear, and seals up for safekeeping after blending 110 days again.
Embodiment 3
Use this Compound Chinese Herbs for Fatigue-Resistance of Animal treatment eczema effect example:
1, patient: Luo, the man, 53 years old, Guangxi Lin school principal suffered from this persistent ailment more than ten years, the treatment front face is gross distortion, and is uneven, double-legged enlargement, whole skin blackout, the hurt like hell of walking, 10 minutes of not standing, and after this persistent ailment arrived to a certain degree, worsen very fast.The treatment of giving and accepting is very itched after 72 hours and is reduced gradually, pain relief, and the whole body colour of skin is normal gradually after 30 days, and this patient is the eczema recovery from illness after 60 days, so the both legs that the people suffers from both feet simultaneously sprains, and belongs to complication, so treatment time is longer.
Claims (3)
1. application compress for the treatment of eczema, it is characterized in that: it is to be immersed in respectively in the rice vinegar through boiling cooling by Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli Chinese crude drug, inoculate acetobacter, when different fermentations behind the indirect fermentation, again its fermentation liquid is blent and made, wherein:
Described acetobacter is acetobacter (Acetobacter sp.) GLYSM66 CCTCC NO:M2011238;
The solid-liquid ratio of described each medical material and rice vinegar is 1 ︰ (8-10);
Described fermentation time is respectively: Rhizoma Smilacis Glabrae 85-95 days; Fructus Forsythiae 85-95 days; Herba Schizonepetae 85-95 days; Folium Artemisiae Argyi 85-95 days; Mirabilitum 145-155 days; Herba speranskiae tuberculatae 85-95 days; Radix Glycyrrhizae 85-95 days; Pericarpium Zanthoxyli 145-155 days;
The weight part ratio that described each fermentation liquid is blent is: native Fu Siberian cocklebur ︰ connects and sticks up ︰ chaste tree mustard ︰ Ai Ye ︰ Piao ︰ (2-4) ︰ (5-7) ︰ (4-6) ︰ (9-11) ︰ (5-7) ︰ (2-4) ︰ (0.8-2) of the sweet careless ︰ Pericarpium Zanthoxyli of the saturating bone grass ︰ of ︰=(2-4) that disappears.
2. a preparation method for the treatment of the application compress of eczema is characterized in that: comprise the steps:
(1) Chinese crude drug Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli were pulverized respectively 100 orders, and autoclaving 30 minutes, for subsequent use;
(2) rice vinegar is boiled with warm fire, naturally cool to room temperature, for subsequent use;
(3) 8 kinds of Chinese crude drugs step (1) being handled well are immersed in respectively in the rice vinegar after step (2) sterilization, and solid-liquid ratio is 1 ︰ (8-10);
(4) with acetobacter GLYSM66 with LB culture medium amplification culture after, be inoculated into respectively in each medical material soak, its inoculum concentration is: medical material soaks the ︰ 1 of the volume ratio of Ye ︰ strain=(20-50);
(5) ferment at normal temperatures, fermentation time is respectively: Rhizoma Smilacis Glabrae 85-95 days; Fructus Forsythiae 85-95 days; Herba Schizonepetae 85-95 days; Folium Artemisiae Argyi 85-95 days; Mirabilitum 145-155 days; Herba speranskiae tuberculatae 85-95 days; Radix Glycyrrhizae 85-95 days; Pericarpium Zanthoxyli 145-155 days;
(6) blend: the weight part ratio that each medicine fermentation liquid is blent is: native Fu Siberian cocklebur ︰ connects and sticks up ︰ chaste tree mustard ︰ Ai Ye ︰ Piao ︰ (2-4) ︰ (5-7) ︰ (4-6) ︰ (9-11) ︰ (5-7) ︰ (2-4) ︰ (0.8-2) of the sweet careless ︰ Pericarpium Zanthoxyli of the saturating bone grass ︰ of ︰=(2-4) that disappears;
(7) seal up for safekeeping again after blending more than 3 months.
3. preparation method according to claim 2, it is characterized in that: the weight part ratio that described each the medicine fermentation liquid of step (6) is blent is: native Fu Siberian cocklebur ︰ connects and sticks up the ︰ chaste tree mustard ︰ Ai Ye ︰ Piao sweet careless ︰ Pericarpium Zanthoxyli of the saturating bone grass ︰ of ︰=3 ︰, 3 ︰, 6 ︰, 5 ︰, 10 ︰, 6 ︰, 3 ︰ 1 that disappear.
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| CN 201210287998 CN102755572B (en) | 2011-10-02 | 2012-08-14 | Medicine for external application for treating eczema disease and preparation method thereof |
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| CN105079671A (en) * | 2015-08-31 | 2015-11-25 | 颜海 | External-application medicated wine for treating eczema |
| CN105169342A (en) * | 2015-10-12 | 2015-12-23 | 临沂草之美医药科技有限公司 | Traditional Chinese medicine composition for treating eczema and preparation method thereof |
| CN105770839A (en) * | 2015-10-12 | 2016-07-20 | 烟台市蓝洋之草医药生物科技有限公司 | Method for preparing traditional Chinese medicinal composition for treating eczema |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634239A (en) * | 2004-09-22 | 2005-07-06 | 曾燕 | Chinese medicinal composition for skin caring and its application method |
| CN1778405A (en) * | 2004-11-26 | 2006-05-31 | 鞠文军 | Externally-applied heat-temperature therapeutic health-care bag with Chinese medicine |
| CN101167847A (en) * | 2007-11-13 | 2008-04-30 | 杨春常 | Traditional Chinese medicinal white spirit preparation for effectively treating skin disease |
| CN101579475A (en) * | 2008-05-18 | 2009-11-18 | 尚爱永 | Traditional Chinese medicine for treating eczema |
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- 2011-10-02 CN CN2011102921981A patent/CN102366573A/en active Pending
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634239A (en) * | 2004-09-22 | 2005-07-06 | 曾燕 | Chinese medicinal composition for skin caring and its application method |
| CN1778405A (en) * | 2004-11-26 | 2006-05-31 | 鞠文军 | Externally-applied heat-temperature therapeutic health-care bag with Chinese medicine |
| CN101167847A (en) * | 2007-11-13 | 2008-04-30 | 杨春常 | Traditional Chinese medicinal white spirit preparation for effectively treating skin disease |
| CN101579475A (en) * | 2008-05-18 | 2009-11-18 | 尚爱永 | Traditional Chinese medicine for treating eczema |
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| CN102366573A (en) | 2012-03-07 |
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