CN105770839A - Method for preparing traditional Chinese medicinal composition for treating eczema - Google Patents
Method for preparing traditional Chinese medicinal composition for treating eczema Download PDFInfo
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- CN105770839A CN105770839A CN201610296382.6A CN201610296382A CN105770839A CN 105770839 A CN105770839 A CN 105770839A CN 201610296382 A CN201610296382 A CN 201610296382A CN 105770839 A CN105770839 A CN 105770839A
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Abstract
The invention relates to a method for preparing a traditional Chinese medicinal composition for treating eczema and belongs to the technical field of traditional Chinese medicine. According to the method, the traditional Chinese medicinal composition is prepared from the following raw materials: radix astragali, rhizoma gastrodiae, fructus kochiae, folium artemisiae argyi, pericarpium zanthoxyli, herba schizonepetae, cortex dictamni, rhizoma coptidis, radix lithospermi, cassia bark, flos albizziae, caulis polygoni multiflora, radix paeoniae alba, fresh ginger and radix glycyrrhizae. The traditional Chinese medicinal composition for treating eczema, prepared by the method disclosed by the invention, has the advantages of quick effects for relieving itching, good treatment effect and no irritation to skin; in addition, a preparation process of the traditional Chinese medicinal composition is simple, convenient and easy to implement; a preparation is stable in medicinal effect; patients have high medication compliance; the traditional Chinese medicinal composition is wide in application range and is easy for popularization and application.
Description
The application be applicant Linyi Cao Zhimei Pharmaceutical Technology Co., Ltd propose application for a patent for invention (denomination of invention is: a kind of Chinese medicine composition treating eczema and preparation method thereof, application number is: 201510654649X, and the applying date is: on October 12nd, 2015) divisional application.
Technical field
A kind of method that the present invention relates to Chinese medicine composition preparing treatment eczema, belongs to technical field of Chinese medicines.
Background technology
Eczema is a kind of common allergic inflammation dermatoses, and its feature is pleomorphism erythra, oozes out tendency, symmetrical, it is easy to recurrence and chronicity.More eczematosis, because of more complicated, thought anaphylactic disease at present, is belonged to type Ⅳ allergy.Anaphylactogen may be from the external world, also may be from internal body.The toxin of enviromental allergen such as chemical drugs, cosmetics, dyestuff, some animal, foreign preteins and some pollen, the dust etc. such as egg, fish, shrimp, milk.Internal anaphylactogen such as internal lesions, intestinal parasitic disease, some metabolism, endocrine or digestive tract function imbalance and human body itself some be organized under the impact of some factor, its composition changes and forms autoantibody etc..
The traditional Chinese medical science thinks that this disease is lost strong mainly due to disease just taste, endogenous dampness, strongly fragrant heat-transformation of a specified duration, retention of damp-heat in the interior, and then rash color is scarlet for outer more skin, flow liquid of contaminating, and sick recurrent exerbation for a long time, cloudy blood is consumed；Qi-blood disharmony, the raw wind of dryness-transformation, failure of skin and muscle to be nourished, coarse plumpness, touching difficulty is more.In a word, this disease belongs to damp and hot, and heat in blood, dampness, caused by blood is dry.Clinic according to the body constitution of patient, arteries and veins card, Selection drug, should can not adhere rigidly to into side.
Western medical treatment is based on antihistamine drug for oral administration, medicine for external use is mainly selected the soaks such as solution, lotion, paste or ointment according to different stadium performances or is coated with outward, when there is secondary infection, can consider to use antibiotic therapy, but be there is bigger toxic and side effects by some Western medicine in skin, the treatment such as antibiotic, hormone simultaneously not only can directly affect the health of patient, and long period or short-term heavy dose use, and meeting addiction also causes drug dependence dermatitis.
Folium Artemisiae Argyi is the dried leaves of feverfew Chinese mugwort ArtemisiaargyiLevl.etVant., has another name called moxibustion grass, Artemisia argyi Levl. et Van. var. argyi cv. Qiai, Radix Artemisia ordosicae and Ai Peng etc., and its bitter in the mouth is pungent, warm in nature；Return liver,spleen,kidney warp；Having the effects such as blood of regulating the flow of vital energy, warming the meridian for stopping bleeding, dispersing cold for relieving pain, be a kind of gynecological good medicine, be used for spitting blood, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile.Pharmacological research represents, the various bacteria such as staphylococcus aureus, escherichia coli, bacillus subtilis are all had antibacterial action by Folium Artemisiae Argyi in vitro, and the anaphylactic shock guinea-pigs that ovalbumin is caused by Oleum Folium Artemisiae Argyi simultaneously has antagonism, it is possible to decrease mortality rate.Chinese patent application 201210287998.9 discloses a kind of application compress treating eczema, this medicine is by being separately immersed in the rice vinegar through boiling cooling by Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli Chinese crude drug, inoculate acetobacter, when different fermentations after indirect fermentation, then its fermentation liquid is blent make.This medicine has certain curative effect in treatment eczema, but this process for preparing medicine is complicated, and treatment is long for the course for the treatment of.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of method of Chinese medicine composition preparing treatment eczema, the Chinese medicine composition that the method prepares can Quick itch stopping, pointed strong, advantage that good effect, relapse rate are low, there is good long-term effect.
The Chinese medicine composition for the treatment of eczema of the present invention is made up of the raw material of preparing of following parts by weight: Radix Astragali 13-19 part, Rhizoma Gastrodiae 12-16 part, Fructus Kochiae 10-20 part, Folium Artemisiae Argyi 18-22 part, Pericarpium Zanthoxyli 13-22 part, Herba Schizonepetae 18-24 part, Cortex Dictamni 12-18 part, Rhizoma Coptidis 10-16 part, Radix Arnebiae (Radix Lithospermi) 18-24 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 12-18 part, Flos Albiziae 15-19 part, Caulis Polygoni Multiflori 14-18 part, Radix Paeoniae Alba 11-17 part, Rhizoma Zingiberis Recens 12-18 part and Radix Glycyrrhizae 6-16 part.
Further, described Chinese medicine composition is made up of the raw material of preparing of following parts by weight: the Radix Astragali 13 parts, 12 parts of Rhizoma Gastrodiae, the Fructus Kochiae 10 parts, Folium Artemisiae Argyi 18 parts, 13 parts of Pericarpium Zanthoxyli, Herba Schizonepetae 18 parts, Cortex Dictamni 12 parts, Rhizoma Coptidis 10 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, 12 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 15 parts, Caulis Polygoni Multiflori 14 parts, the Radix Paeoniae Alba 11 parts, 12 parts of Rhizoma Zingiberis Recens and 6 parts of Radix Glycyrrhizae.
Further, described Chinese medicine composition is made up of the raw material of preparing of following parts by weight: the Radix Astragali 19 parts, 16 parts of Rhizoma Gastrodiae, the Fructus Kochiae 20 parts, Folium Artemisiae Argyi 22 parts, 22 parts of Pericarpium Zanthoxyli, Herba Schizonepetae 24 parts, Cortex Dictamni 18 parts, Rhizoma Coptidis 16 parts, Radix Arnebiae (Radix Lithospermi) 24 parts, 18 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 19 parts, Caulis Polygoni Multiflori 18 parts, the Radix Paeoniae Alba 17 parts, 18 parts of Rhizoma Zingiberis Recens and 16 parts of Radix Glycyrrhizae.
Further, described Chinese medicine composition is made up of the raw material of preparing of following parts by weight: the Radix Astragali 16 parts, 14 parts of Rhizoma Gastrodiae, the Fructus Kochiae 15 parts, Folium Artemisiae Argyi 20 parts, 17 parts of Pericarpium Zanthoxyli, Herba Schizonepetae 22 parts, Cortex Dictamni 16 parts, Rhizoma Coptidis 14 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, 16 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 16 parts, Caulis Polygoni Multiflori 16 parts, the Radix Paeoniae Alba 15 parts, 16 parts of Rhizoma Zingiberis Recens and 10 parts of Radix Glycyrrhizae.
Further, described Chinese medicine composition is made into paste, gel, ointment, ointment or liniment.
The method of a kind of Chinese medicine composition preparing treatment eczema of the present invention, comprises the following steps:
(1) take Rhizoma Gastrodiae 12-16 part by weight to clean, crushed after being dried, crosses 80-100 mesh sieve, and adding Rhizoma Gastrodiae coarse powder weight 8-12 times amount volume fraction is the ethanol of 60-80%, soak 6-12 hour, supersound extraction twice at 44-65 DEG C of temperature, each 30-50 minute, supersonic frequency was 20-30kHz, filter, merging filtrate, when filtrate reduced in volume is to 60 DEG C, relative density is the clear paste of 1.10-1.20, obtains Rhizoma Gastrodiae extract；
(2) Radix Astragali 13-19 part, Fructus Kochiae 10-20 part and Folium Artemisiae Argyi 18-22 part are taken by weight, pulverize, add the ethanol of the concentration 75-80% of above-mentioned total amount 4-6 times of weight of coarse powder, reflux, extract, 2-3 time, each 2-5 hour, filter, merging filtrate, decompression is distilled off ethanol, and to be concentrated into 55 DEG C of-60 DEG C of relative densities be the Chinese medical concrete of 1.20-1.30；
(3) take Pericarpium Zanthoxyli 13-22 part, Herba Schizonepetae 18-24 part, Cortex Dictamni 12-18 part, Rhizoma Coptidis 10-16 part, Radix Arnebiae (Radix Lithospermi) 18-24 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 12-18 part, Flos Albiziae 15-19 part, Caulis Polygoni Multiflori 14-18 part, Radix Paeoniae Alba 11-17 part, Rhizoma Zingiberis Recens 12-18 part and Radix Glycyrrhizae 6-16 part by weight to be pulverized and mixed, add water soaking 12-24 hour of above-mentioned coarse powder gross weight 8-10 times amount, decoct 1-3 hour；Filtering, merge twice filtrate, it is the Chinese medical concrete of 1.20-1.30 that filtrate is concentrated at 50 DEG C-60 DEG C relative density；
(4) Rhizoma Gastrodiae extract step (1) obtained obtains with step (2) Chinese medical concrete and the Chinese medical concrete that step (3) obtains mix, and dry, pulverize, to obtain final product.
The source of Chinese crude drug, nature and flavor used by Chinese medicine composition of the present invention, return through and effect:
The Radix Astragali: for the dry root of leguminous plant Radix Astragali or Radix Astagali；Sweet, tepor；Return lung, spleen, liver, kidney channel；Tonifying Qi and lifting yang, benefit is had to defend the function of consolidating superficial resistance.
Rhizoma Gastrodiae: the dry tuber of the orchid family Gastrodia plant Rhizoma Gastrodiae, taste taste, sweet, property is put down；Return Liver Channel；Endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral.
The Fructus Kochiae: this product is the dry mature fruit of the chenopod Fructus Kochiae；Acrid in the mouth, hardship, cold in nature；Return kidney, bladder warp；Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort；Acrid in the mouth, hardship, warm in nature；Return spleen, liver, kidney channel；Regulate the flow of vital energy blood, by cold-damp, dispersing cold for relieving pain, warming the meridian for stopping bleeding.
Pericarpium Zanthoxyli: this product is dry mature skin (Pericarpium Zanthoxyli) and the seed (Semen zanthoxyli) of rutaceae Capsicum annuum L. (fragrant green pepper, Zanthoxylum schinifolium, Pericarpium Zanthoxyli, Canis familiaris L. green pepper) or Pericarpium Zanthoxyli (another name for Sichuan Province green pepper, Fructus Zanthoxyli, Capsicum tetragonum, pericarpium zanthoxyli bungeani, Radix Campylotropis Hirtella (Herba Myrsines Africanae))；Acrid in the mouth, warm in nature；Return spleen, stomach, kidney channel；Warming spleen and stomach for dispelling cold, removing damp and stopping pain, killing parasites for relieving itching.
Herba Schizonepetae: this product is the dry aerial parts of labiate Herba Schizonepetae；Acrid in the mouth, slightly warm in nature；Return lung, Liver Channel；Induce sweat scattered wind, rash.
Cortex Dictamni: this product is the dry root bark of rutaceae shaggy-fruited dittany；Bitter in the mouth, cold in nature；Return spleen, stomach, bladder warp；Heat clearing and damp drying, dispelling wind for relieving itching, removing toxic substances.
Rhizoma Coptidis: this product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall；Bitter in the mouth, cold in nature；GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel；Heat clearing and damp drying, eliminating fire and detoxication.
Radix Arnebiae (Radix Lithospermi): this product is the dry root of comfrey lithospermum euchromum Royle, Radix Arnebiae (Radix Lithospermi) or arnebia guttata Bunge；Sweet in the mouth, salty, cold in nature；GUIXIN, Liver Channel；Removing heat from blood, invigorates blood circulation, rash of detoxifying.
Cortex cinnamomi japonici (Ramulus Cinnamomi): this product is the bark in canella Cinnamomum japonica, cloudy fragrant, cinnamomum chingii Metcalf or osmanthus, river etc.；Acrid in the mouth, sweet, warm in nature；Return spleen, stomach, liver, kidney channel；Warming the spleen stomach, warm Liver and kidney, cold-dispelling pain-relieving, dissipating blood stasis for subsidence of swelling.
Flos Albiziae: this product is the dry inflorescence of leguminous plant Herba Albiziae；Sweet in the mouth, property is put down；GUIXIN, Liver Channel；Shu Yu, regulates the flow of vital energy, and calms the nerves, active.
Caulis Polygoni Multiflori: for rattan or the leaf bine stem of polygonum multiflorum thunb；Sweet in the mouth, micro-hardship, property is put down；GUIXIN, Liver Channel；
Tranquilizing by nourishing the heart, dispels the wind, dredging collateral.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae；Bitter in the mouth, acid, cold nature；Return liver, spleen channel；Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Rhizoma Zingiberis Recens: this product is the fresh rhizome of zingiber；Acrid in the mouth, slightly warm in nature；Return lung, spleen, stomach warp；Induce sweat cold expelling.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.；Sweet in the mouth, property is put down；GUIXIN, lung, spleen, stomach warp；Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
Chinese medicine composition of the present invention is with the Radix Astragali, Rhizoma Gastrodiae, the Fructus Kochiae, Folium Artemisiae Argyi, Herba Schizonepetae, Pericarpium Zanthoxyli for monarch drug, warming middle-JIAO to relieve pain, detoxifying and relieving itching；With Cortex Dictamni, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi) for ministerial drug, rash of detoxifying, heat clearing and damp drying, eliminating fire and detoxication；With Caulis Polygoni Multiflori, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens for adjuvant drug, tranquilizing by nourishing the heart, expelling pus and toxin by strengthening QI；With Radix Glycyrrhizae for making medicine, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription, make all medicines arrange in pairs or groups, jointly reach sterilizing and itch-relieving, rash of detoxifying, expelling pus and toxin by strengthening QI, effect of promoting tissue regeneration and ulcer healing, eczema is had significant therapeutic effect.
Verifying through clinical trial, Chinese medicine composition prepared by the present invention has the advantage that compared with existing medicine
1) Chinese medicine composition prepared by the present invention can significantly improve the symptom of eczema, rapid-action, treats short treating period, and can suppress secondary infection；
2) Chinese medicine composition that the present invention prepares is natural pure Chinese medicinal preparation, and toxic and side effects is little, to no skin irritation；
3) the Chinese medicine composition synergism that the present invention prepares is strong, and using dosage is little, will not produce drug dependence simultaneously.
Detailed description of the invention
Further describing the present invention below by way of specific embodiment, the present invention is not limited only to following example.Within the scope of the invention or without departing from present disclosure, spirit and scope, change, combination or the replacement that the present invention is carried out, will be apparent to the person skilled in the art, and be included within the scope of the present invention.
Embodiment l
The embodiment of the present invention 1 Chinese medicine composition is made up of the raw material of preparing of following parts by weight: the Radix Astragali 13 parts, 12 parts of Rhizoma Gastrodiae, the Fructus Kochiae 10 parts, Folium Artemisiae Argyi 18 parts, 13 parts of Pericarpium Zanthoxyli, Herba Schizonepetae 18 parts, Cortex Dictamni 12 parts, Rhizoma Coptidis 10 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, 12 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 15 parts, Caulis Polygoni Multiflori 14 parts, the Radix Paeoniae Alba 11 parts, 12 parts of Rhizoma Zingiberis Recens and 6 parts of Radix Glycyrrhizae.
Preparation method:
S1: take Rhizoma Gastrodiae and clean, crushed after being dried, crosses 80 mesh sieves, and adding Rhizoma Gastrodiae coarse powder weight 8 times amount volume fraction is the ethanol of 60%, soak 6 hours, supersound extraction twice at 44 DEG C of temperature, each 30 minutes, supersonic frequency was 20kHz, filter, merging filtrate, when filtrate reduced in volume is to 60 DEG C, relative density is the clear paste of 1.10, obtains Rhizoma Gastrodiae extract；
S2: take the Radix Astragali, the Fructus Kochiae and Folium Artemisiae Argyi, pulverizes, adds the ethanol of the concentration 75% of above-mentioned 4 times of weight of coarse powder total amount, reflux, extract, 2 times, each 2 hours, filters, merging filtrate, and decompression is distilled off ethanol, and to be concentrated into 55 DEG C of relative densities be the Chinese medical concrete of 1.20；
S3: take Pericarpium Zanthoxyli, Herba Schizonepetae, Cortex Dictamni, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae, Caulis Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens and Radix Glycyrrhizae and be pulverized and mixed, adds the water soaking 12 hours of above-mentioned coarse powder gross weight 8 times amount, decocts 1 hour；Filtering, merge twice filtrate, it is the Chinese medical concrete of 1.20 that filtrate is concentrated at 50 DEG C relative density；
S4: Chinese medical concrete that the Rhizoma Gastrodiae extract obtained by step S1 obtains with step S2 and the Chinese medical concrete that step S3 obtains mix, and dry, pulverize, add corresponding adjuvant, make ointment.
Embodiment 2
The embodiment of the present invention 2 Chinese medicine composition is made up of the raw material of preparing of following parts by weight: the Radix Astragali 19 parts, 16 parts of Rhizoma Gastrodiae, the Fructus Kochiae 20 parts, Folium Artemisiae Argyi 22 parts, 22 parts of Pericarpium Zanthoxyli, Herba Schizonepetae 24 parts, Cortex Dictamni 18 parts, Rhizoma Coptidis 16 parts, Radix Arnebiae (Radix Lithospermi) 24 parts, 18 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 19 parts, Caulis Polygoni Multiflori 18 parts, the Radix Paeoniae Alba 17 parts, 18 parts of Rhizoma Zingiberis Recens and 16 parts of Radix Glycyrrhizae.
Preparation method is similar with embodiment 1, makes ointment.
Embodiment 3
The embodiment of the present invention 3 Chinese medicine composition is made up of the raw material of preparing of following parts by weight: the Radix Astragali 16 parts, 14 parts of Rhizoma Gastrodiae, the Fructus Kochiae 15 parts, Folium Artemisiae Argyi 20 parts, 17 parts of Pericarpium Zanthoxyli, Herba Schizonepetae 22 parts, Cortex Dictamni 16 parts, Rhizoma Coptidis 14 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, 16 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 16 parts, Caulis Polygoni Multiflori 16 parts, the Radix Paeoniae Alba 15 parts, 16 parts of Rhizoma Zingiberis Recens and 10 parts of Radix Glycyrrhizae.
Preparation method is similar with embodiment 1, makes gel.
Chinese medicine composition pharmacodynamic study of the present invention
Test one: the Chinese medicine composition of the present invention development test to ear eczema mice
Experimental animal: provided cleaning grade kunming mice 36, body weight 22g ± 4g, male and female half and half by certain Bioisystech Co., Ltd.36 mices are randomly divided into 3 groups, often group 12.
Ear eczema Establishment of mouse model: first day two-sided dinitrochlorobenzene (DNCB) the solution sensitization smearing 40 μ L5% at mice ears, the DNCB solution smearing 40 μ L1% on 4th day, once smeared once every four days afterwards, totally 5 times, set up ear eczema mouse model.
Dosage regimen:
Treatment group: take the Chinese medicine composition ointment of the present invention that the embodiment of the present invention 1 prepares；Smearing DNCB to excite and be coated with trial drug outside rear 24h, 48h, 72h inside mice ears, 1g/ is each, 2 times/day every time.
Positive controls: taking Compound Dexamethasone Cream (Baiyunshan Hejigong Medicine Factory of Guangzhou Baiyunshan Pharmaceutical Co., Ltd., the quasi-word H44024298 of traditional Chinese medicines), dosage regimen is with A group.
Model control group: taking the ointment of not drug containing in the embodiment of the present invention 1, dosage regimen is with treatment group.
Carry out skin lesion degree score by following standard: ears substantially redness thickens and oozes out, or substantially keratinization incrustation person remembers 3 points；Mild redness, oozes out inconspicuous, or moderate keratinization person is designated as 2 points；Red and swollen and ooze out all inconspicuous person, or slight keratinization person is designated as 1 point；Normal skin is 0 point.
Use spiral micrometer to measure ear swelling thickness respectively simultaneously.
Table 1 Ge Zu ear skin lesion situation compares
Note: compare with model control group,* P< 0.05；** P< 0.01.
Adopt other embodiment medicines to test, achieve similar therapeutic effect.
Treatment group is compared with model control group, and mouse ear skin lesion integration and ear swelling thickness all have significant difference.Test data shows, treatment group mice is compared with model control group mice, and ear's skin lesion is clearly better, and ear swelling degree substantially reduces, and result of the test shows, the traditional Chinese medicine composition for treating of the present invention is obvious with prevention eczema effect, can be used for clinical expansion.
Test two: the clinical trial of Chinese medicine composition of the present invention
One, diagnostic criteria
Draft with reference to the content of " diagnosis basis of eczema " in " Chinese medical disease Standardization of diagnosis and curative effect ".Diagnostic criteria is:
1, acute eczema:
1) skin lesion is pleomorphism, as flushing, pimple, vesicle, erosion, ooze out, crust, desquamation, constant kind form exists simultaneously.
2) onset is anxious, conscious scorching hot, violent pruritus.
3) skin lesion is often symmetrical, common with head, face, distal limbs, scrotum etc..Can general whole body.
4) subacute or chronic eczema can be developed into, time light time weight, repeatedly do not heal.
2, subacute eczema: skin lesion oozes out less, based on pimple, papulovesicle, incrustation, squama.Having slight rotten to the corn face, color is more dark red.Also visible mild infiltration, violent pruritus.
3, chronic eczema: many limits office is in a certain position, and boundary is clear, has significantly plump infiltration, rough surface, or become in lichen sample, color is brown red or brown, is often accompanied by papulovesicle, crust, scratch.The moistening change of tendency, normal recurrent exerbation, time light time weight, have paroxysmal pruritus.
Two, clinical trial protocol
1, subjects basic document:
The present invention collects clinical eczema volunteer 120 example, male 88 examples, female 32 example, age 15-45 year, all experimenters are randomly divided into 2 groups, often group 60,2 group cases through statistical analysis, have comparability in sex, age, the course of disease etc..
2, trial drug and test method:
Treatment group: the ointment of the embodiment of the present invention 1 preparation, every ointment contains medicine 12.5g, spreads upon eczema place, and every day, secondary, smeared 10 days continuously.
Positive controls: smear Compound Dexamethasone Cream (Baiyunshan Hejigong Medicine Factory of Guangzhou Baiyunshan Pharmaceutical Co., Ltd., the quasi-word H44024298 of traditional Chinese medicines), twice daily, smear 10 days continuously.
3, criterion of therapeutical effect:
Effective: eczema erythema significantly reduces, attack times reduces.
Invalid: comparing with before treatment, symptom does not disappear or increases the weight of on the contrary.
Recurrence: cure latter 3 months and run into warm and still show effect.
4, therapeutic outcome: as shown in table 2.
Table 2 therapeutic effect
Result of the test shows, the effect for the treatment of group traditional Chinese medicine composition for treating eczema of the present invention is better than positive control drug Compound Dexamethasone Cream.Treatment group is compared with positive controls, the total effective rate for the treatment of group is 96.7%, and higher than the total effective rate 86.7% of positive controls group, and the recurrence number of cases for the treatment of group is substantially less than the recurrence number of cases of positive controls, clinical observation, treatment group patient has no any untoward reaction at therapeutic process.Traditional Chinese medicine composition for treating eczema of the present invention is rapid-action, and safety is high, and relapse rate is low, and clinical generalization value is high.
Claims (5)
1. the method for the Chinese medicine composition preparing treatment eczema, it is characterised in that comprise the following steps:
(1) take Rhizoma Gastrodiae 12-16 part by weight to clean, crushed after being dried, crosses 80-100 mesh sieve, and adding Rhizoma Gastrodiae coarse powder weight 8-12 times amount volume fraction is the ethanol of 60-80%, soak 6-12 hour, supersound extraction twice at 44-65 DEG C of temperature, each 30-50 minute, supersonic frequency was 20-30kHz, filter, merging filtrate, when filtrate reduced in volume is to 60 DEG C, relative density is the clear paste of 1.10-1.20, obtains Rhizoma Gastrodiae extract；
(2) Radix Astragali 13-19 part, Fructus Kochiae 10-20 part and Folium Artemisiae Argyi 18-22 part are taken by weight, pulverize, add the ethanol of the concentration 75-80% of above-mentioned total amount 4-6 times of weight of coarse powder, reflux, extract, 2-3 time, each 2-5 hour, filter, merging filtrate, decompression is distilled off ethanol, and to be concentrated into 55 DEG C of-60 DEG C of relative densities be the Chinese medical concrete of 1.20-1.30；
(3) take Pericarpium Zanthoxyli 13-22 part, Herba Schizonepetae 18-24 part, Cortex Dictamni 12-18 part, Rhizoma Coptidis 10-16 part, Radix Arnebiae (Radix Lithospermi) 18-24 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 12-18 part, Flos Albiziae 15-19 part, Caulis Polygoni Multiflori 14-18 part, Radix Paeoniae Alba 11-17 part, Rhizoma Zingiberis Recens 12-18 part and Radix Glycyrrhizae 6-16 part by weight to be pulverized and mixed, add water soaking 12-24 hour of above-mentioned coarse powder gross weight 8-10 times amount, decoct 1-3 hour；Filtering, merge twice filtrate, it is the Chinese medical concrete of 1.20-1.30 that filtrate is concentrated at 50 DEG C-60 DEG C relative density；
(4) Rhizoma Gastrodiae extract step (1) obtained obtains with step (2) Chinese medical concrete and the Chinese medical concrete that step (3) obtains mix, and dry, pulverize, to obtain final product.
2. the method for the Chinese medicine composition of preparation treatment eczema according to claim 1, it is characterized in that, the weight portion of the raw material of described Chinese medicine composition is as follows: the Radix Astragali 13 parts, 12 parts of Rhizoma Gastrodiae, the Fructus Kochiae 10 parts, Folium Artemisiae Argyi 18 parts, 13 parts of Pericarpium Zanthoxyli, Herba Schizonepetae 18 parts, Cortex Dictamni 12 parts, Rhizoma Coptidis 10 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, 12 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 15 parts, Caulis Polygoni Multiflori 14 parts, the Radix Paeoniae Alba 11 parts, 12 parts of Rhizoma Zingiberis Recens and 6 parts of Radix Glycyrrhizae.
3. the method for the Chinese medicine composition of preparation treatment eczema according to claim 1, it is characterized in that, the weight portion of the raw material of described Chinese medicine composition is as follows: the Radix Astragali 19 parts, 16 parts of Rhizoma Gastrodiae, the Fructus Kochiae 20 parts, Folium Artemisiae Argyi 22 parts, 22 parts of Pericarpium Zanthoxyli, Herba Schizonepetae 24 parts, Cortex Dictamni 18 parts, Rhizoma Coptidis 16 parts, Radix Arnebiae (Radix Lithospermi) 24 parts, 18 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 19 parts, Caulis Polygoni Multiflori 18 parts, the Radix Paeoniae Alba 17 parts, 18 parts of Rhizoma Zingiberis Recens and 16 parts of Radix Glycyrrhizae.
4. the method for the Chinese medicine composition of preparation treatment eczema according to claim 1, it is characterized in that, the weight portion of the raw material of described Chinese medicine composition is as follows: the Radix Astragali 16 parts, 14 parts of Rhizoma Gastrodiae, the Fructus Kochiae 15 parts, Folium Artemisiae Argyi 20 parts, 17 parts of Pericarpium Zanthoxyli, Herba Schizonepetae 22 parts, Cortex Dictamni 16 parts, Rhizoma Coptidis 14 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, 16 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 16 parts, Caulis Polygoni Multiflori 16 parts, the Radix Paeoniae Alba 15 parts, 16 parts of Rhizoma Zingiberis Recens and 10 parts of Radix Glycyrrhizae.
5. the method according to the Chinese medicine composition of the arbitrary described preparation treatment eczema of claim 1-4, it is characterised in that: described Chinese medicine composition is paste, gel, ointment, ointment or liniment.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658612A (en) * | 2008-08-28 | 2010-03-03 | 天津市中宝制药有限公司 | Powder for treating chronic eczema |
| CN102366573A (en) * | 2011-10-02 | 2012-03-07 | 莫寿科 | Externally applied medicine for treating eczema and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658612A (en) * | 2008-08-28 | 2010-03-03 | 天津市中宝制药有限公司 | Powder for treating chronic eczema |
| CN102366573A (en) * | 2011-10-02 | 2012-03-07 | 莫寿科 | Externally applied medicine for treating eczema and preparation method thereof |
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