CN102366573A - Externally applied medicine for treating eczema and preparation method thereof - Google Patents
Externally applied medicine for treating eczema and preparation method thereof Download PDFInfo
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- CN102366573A CN102366573A CN2011102921981A CN201110292198A CN102366573A CN 102366573 A CN102366573 A CN 102366573A CN 2011102921981 A CN2011102921981 A CN 2011102921981A CN 201110292198 A CN201110292198 A CN 201110292198A CN 102366573 A CN102366573 A CN 102366573A
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Abstract
The invention provides an externally applied medicine for treating eczema and a preparation method thereof. The preparation method comprises the following steps: respectively soaking glabrous greenbrier rhizome, Fructus Forsythiae, herba schizonepetae, folium artemisiae argyi, sodium sulfate, american lopseed, licorice root and pepper in rice vinegar which is boiled and cooled; inoculating Acetobacter sp. GLYSM66 CCTCC NO:M2011238, and fermenting for different fermentation times; and blending the fermentation liquids to obtain the externally applied medicine for treating eczema. The externally applied medicine for treating eczema has strong functions of activating blood circulation to dissipate blood stasis, relaxing the tendons, activating the collaterals, dispelling wind, eliminating dampness, promoting the circulation of qi, diminishing inflammation, alleviating pain and relieving itching. The externally applied medicine for treating eczema has the advantages of obvious treatment effect and low treatment cost; and the preparation method is simple.
Description
Technical field
The present invention relates to application compress, specifically is a kind of application compress of treating eczema and preparation method thereof.
Background technology
Eczema is the scytitis that is caused by multiple internal and external factor; Different according to eczema position symptom; Can be divided into legs eczema, eczema scrotum, breast eczema or hand eczema etc.; Many at present employing 0.25% procaine injection 10～20ml vitaminize C 500mg intravenous injection is embrocated the affected part to antipruritic, the germ-resistant medicine of the many employings of tinea of locality.The chronic limitation eczema long with obstinate for stadium adopts physics and X-ray therapy, liquid nitrogen cryotherapy, superficial X-ray or radionuclide (32P or 90Sr) plastering therapy, and medical expense is high, and side effect is big.
Because the processing procedure of most of Chinese medicines is through boiling, extracting the method for the effective ingredient in the Chinese crude drug with decocting in water.But this method has following shortcoming: 1, owing to boil time, temperature, pressure and can not unify, the effective ingredient in the Chinese crude drug is difficult to be extracted out fully; 2, it is very high to boil in the process temperature, might destroy the effective ingredient of those heat sensitivitys; 3, be the intermediate of effective ingredient mostly through boiling the Chinese medicine ingredients that lixiviate goes out merely; Must transform through the intravital probiotic bacteria of people, finally become acting effective ingredient, get into blood; Because human body probiotic bacteria situation is different; Thereby produce the situation such as slow or ineffective that takes effect, therapeutic effect is unsatisfactory, and the exploitation low toxicity, the antieczematic new drug is the vital task of diseases prevention and treatment efficiently.
Summary of the invention
To the deficiency of prior art, the present invention provides application compress of a kind of treatment eczema that can nurse one's health dredging the meridian, antipruritic fast, good effect, have no side effect again and preparation method thereof.
The technical scheme that realizes the object of the invention is:
A kind of application compress of treating eczema; It is to be immersed in respectively in boiling refrigerative rice vinegar by Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli Chinese crude drug; Inoculate acetobacter, when different fermentations, behind the indirect fermentation, its fermentation liquid is blent processed again.
Described acetobacter is acetobacter (Acetobacter sp.) GLYSM66 CCTCC NO:M2011238; Be called for short acetobacter GLYSM66; Be that the inventor screens from common acetobacter; (be called for short: CCTCC), deposit number is CCTCC NO:M2011238 to be deposited in the typical Culture Center of Wuhan University China on July 5th, 2011.This acetobacter has the function of degraded several kinds of Chinese medicinal materials or composite Chinese crude drug.
The method for preparing of application compress of the present invention comprises the steps:
(1) Chinese crude drug Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli pulverize separately are crossed 100 orders, and autoclaving 30 minutes, subsequent use;
(2) rice vinegar is boiled with warm fire, naturally cool to room temperature, subsequent use;
(3) eight kinds of Chinese crude drugs step (1) being handled are immersed in respectively in the rice vinegar after step (2) sterilization, and solid-liquid ratio is 1 ︰ (8-10);
(4) with acetobacter GLYSM66 with LB culture medium amplification culture after, be inoculated into respectively in each medical material soak, its inoculum concentration is: medical material soaks the ︰ 1 of the volume ratio of Ye ︰ strain=(20-50);
(5) ferment at normal temperatures, fermentation time is respectively: Rhizoma Smilacis Glabrae 85-95 days; Fructus Forsythiae 85-95 days; Herba Schizonepetae 85-95 days; Folium Artemisiae Argyi 85-95 days; Mirabilitum 145-155 days; Herba speranskiae tuberculatae 85-95 days; Radix Glycyrrhizae 85-95 days; Pericarpium Zanthoxyli 145-155 days;
(6) blend: get each medicine fermentation liquid and blend, its weight part ratio is: native Fu Siberian cocklebur ︰ connects and sticks up ︰ chaste tree mustard ︰ Ai Ye ︰ Piao nitre ︰ and pass through ︰ (2-4) ︰ (5-7) ︰ (4-6) ︰ (9-11) ︰ (5-7) ︰ (2-4) ︰ (0.8-2) of the sweet careless ︰ Pericarpium Zanthoxyli of bone grass ︰=(2-4);
(7) seal up for safekeeping again after blending more than 3 months.
The method for using of this medicine has two kinds, can use wherein a kind of, also can two kinds of combinations:
First method is:
(1) take a shower earlier, patient's pore is fully opened after, with this medicinal liquid fumigation 30 minutes to 1 hour;
(2) put on the clothes that soaked with this medicinal liquid, the parcel health;
(3) toast whole body with infrared ray;
(4) carry out channels and network vessels regulation.
10 days is a course of treatment.
Second method is: external application, suction medicinal liquid with absorbent paper, and apply at the eczema happening part, the external preservative film encases, and fixes with adhesive tape, and applied 6 hours every day at least, and 7 days is a course of treatment.
The external application of the pharmacological effects of various herbs, according to "Chinese Dictionary" records: Smilax with detoxification, dehumidification, Lee joints; forsythia with detoxification, and reducing swelling; Nepeta solution table scattered with the wind, Touzhen; leaves with cold pain, warm through the bleeding; Puxiao with heat swelling, Endometriosis; Speranskia aka wild peas, with eradicates rheumatism, blood Shujin, pain; licorice Spleen Qi, detoxification, relieve pain, to reconcile various drugs; pepper temperature aborted, insecticidal itching; these medicines by the present invention Acetobacter After fermentation, the decomposition and transformation of Chinese herbal medicines, the active ingredient is fully released, enhanced potency, while acetic acid bacteria environment, enhanced antioxidant active ingredients, have a stronger blood circulation, Shujin, dispelling wind and dampness, qi and anti-inflammatory analgesic, antipruritic function.Treatment eczema effect is remarkable, and medical expense is low, and method for preparing is simple.
Clinical this medicine of usefulness treatment eczema 6 examples are wherein cured 3 examples fully, significant curative effect 3 examples, and to skin non-stimulated and toxic and side effects.
The specific embodiment
Below through embodiment the present invention is described.
Used acetobacter GLYSM66 obtains through the screening technique that comprises the steps in the present embodiment:
(1) gets Flos Galinsogae Parviflorae, Semen Fagopyri Esculenti root, very heavy group, YIDUOYUN or five kinds of Chinese crude drugs of Rhizoma Paridis, pulverize, cross 100 mesh sieves, autoclaving 30 minutes respectively afterwards, five kinds of Chinese crude drug mixed in equal amounts or deposit subsequent use separately;
(2) use the soaking in rice vinegar medical material, medical material compares public jin ︰ liter with the mass and size of rice vinegar) 1 ︰ (5-10), soaking temperature 20-35 ℃, the soaking fermentation different time;
(3) get the fermentation liquid of different fermentations time; Measure effective ingredient--total flavones and total saponins; Simultaneously through 1000 power microscope microscopies; Total flavones and the total saponin content in the sample of five kinds of Chinese crude drug mixed in equal amounts and the five kinds of single samples of Chinese crude drug relatively, the result finds: biased sample is total flavones and total saponin content height not only, and only has single microorganism in the fermentation liquid; Microbe species in latter's liquid is many.Separation screening is carried out in microorganism to biased sample, and successive transfer culture obtains the acetobacter of the several kinds of Chinese medicinal materials of degrading of the present invention.
The used LB culture medium of the amplification culture of acetobacter described in the present embodiment is by sodium chloride 10g, and peptone 10g, yeast extract 5g add water and be settled to 1L and process.
Embodiment 1
A kind of method for preparing of treating the application compress of eczema comprises the steps:
(1) Chinese crude drug Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli pulverize separately are crossed 100 orders, and autoclaving 30 minutes, subsequent use;
(2) rice vinegar is boiled with warm fire, naturally cool to room temperature, subsequent use;
(3) eight kinds of Chinese crude drugs step (1) being handled well are immersed in respectively in the rice vinegar after step (2) sterilization, and solid-liquid ratio is 1 ︰ (8-10);
(4) with acetobacter GLYSM66 with LB culture medium amplification culture after, be inoculated into respectively in each medical material soak, its inoculum concentration is: medical material soaks the ︰ 1 of the volume ratio of Ye ︰ strain=(20-50);
(5) ferment at normal temperatures, fermentation time is respectively: Rhizoma Smilacis Glabrae 90 days; Fructus Forsythiae 90 days; Herba Schizonepetae 90 days; Folium Artemisiae Argyi 90 days; Mirabilitum 150 days; Herba speranskiae tuberculatae 90 days; Radix Glycyrrhizae 90 days; Pericarpium Zanthoxyli 150 days;
(6) blend: the weight part ratio (kilogram) that each medicine fermentation liquid is blent is: native Fu Siberian cocklebur ︰ even sticks up ︰ chaste tree mustard ︰ Ai Ye ︰ Piao nitre ︰ and passes through the sweet careless ︰ Pericarpium Zanthoxyli of bone grass ︰=3 ︰, 3 ︰, 6 ︰, 5 ︰, 10 ︰, 6 ︰, 3 ︰ 1;
(7) seal up for safekeeping again after blending and promptly processed the compound Chinese medicine preparation in 90 days.
Embodiment 2
Method step according to embodiment 1 carries out; Different is: the weight part ratio (kilogram) that said each the medicine fermentation liquid of step (6) is blent is: native Fu Siberian cocklebur ︰ even sticks up ︰ chaste tree mustard ︰ Ai Ye ︰ Piao nitre ︰ and passes through the sweet careless ︰ Pericarpium Zanthoxyli of bone grass ︰=2.5 ︰, 2.5 ︰, 5.5 ︰, 4.5 ︰, 9.5 ︰, 5.5 ︰, 2.5 ︰ 0.8, seals up for safekeeping after blending 110 days again.
Embodiment 3
Use this compound Chinese medicine preparation for treating eczema effect instance:
1, patient: Luo, the man, 53 years old, school, Guilin principal suffered from this persistent ailment more than ten years; The treatment front face is gross distortion, and is uneven, double-legged enlargement, whole skin blackout; Walk pain unbearably, the 10 fens clock times of not standing, and after this persistent ailment arrived to a certain degree, worsen very fast.The treatment of giving and accepting is very itched after 72 hours and is reduced gradually, pain relief, and the whole body colour of skin is normal gradually after 30 days, and this patient is the eczema recovery from illness after 60 days, so the both legs that the people suffers from both feet simultaneously sprains, and belongs to complication, so treatment time is longer.
Claims (3)
1. application compress of treating eczema; It is characterized in that: it is to be immersed in respectively in boiling refrigerative rice vinegar by Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli Chinese crude drug; Inoculate acetobacter; When different fermentations, behind the indirect fermentation, its fermentation liquid is blent processed again, wherein:
Said acetobacter is acetobacter (Acetobacter sp.) GLYSM66 CCTCC NO:M2011238;
The solid-liquid ratio of said each medical material and rice vinegar is 1 ︰ (8-10);
The weight part ratio that said each fermentation liquid is blent is: native Fu Siberian cocklebur ︰ connects and sticks up ︰ chaste tree mustard ︰ Ai Ye ︰ Piao nitre ︰ and pass through ︰ (2-4) ︰ (5-7) ︰ (4-6) ︰ (9-11) ︰ (5-7) ︰ (2-4) ︰ (0.8-2) of the sweet careless ︰ Pericarpium Zanthoxyli of bone grass ︰=(2-4).
2. a method for preparing of treating the application compress of eczema is characterized in that: comprise the steps:
(1) Chinese crude drug Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli pulverize separately are crossed 100 orders, and autoclaving 30 minutes, subsequent use;
(2) rice vinegar is boiled with warm fire, naturally cool to room temperature, subsequent use;
(3) eight kinds of Chinese crude drugs step (1) being handled well are immersed in respectively in the rice vinegar after step (2) sterilization, and solid-liquid ratio is 1 ︰ (8-10);
(4) with acetobacter GLYSM66 with LB culture medium amplification culture after, be inoculated into respectively in each medical material soak, its inoculum concentration is: medical material soaks the ︰ 1 of the volume ratio of Ye ︰ strain=(20-50);
(5) ferment at normal temperatures, fermentation time is respectively: Rhizoma Smilacis Glabrae 85-95 days; Fructus Forsythiae 85-95 days; Herba Schizonepetae 85-95 days; Folium Artemisiae Argyi 85-95 days; Mirabilitum 145-155 days; Herba speranskiae tuberculatae 85-95 days; Radix Glycyrrhizae 85-95 days; Pericarpium Zanthoxyli 145-155 days;
(6) blend: the weight part ratio that each medicine fermentation liquid is blent is: native Fu Siberian cocklebur ︰ connects and sticks up ︰ chaste tree mustard ︰ Ai Ye ︰ Piao nitre ︰ and pass through ︰ (2-4) ︰ (5-7) ︰ (4-6) ︰ (9-11) ︰ (5-7) ︰ (2-4) ︰ (0.8-2) of the sweet careless ︰ Pericarpium Zanthoxyli of bone grass ︰=(2-4);
(7) seal up for safekeeping again after blending more than 3 months.
3. method for preparing according to claim 2 is characterized in that: the weight part ratio that said each the medicine fermentation liquid of step (6) is blent is: native Fu Siberian cocklebur ︰ even sticks up ︰ chaste tree mustard ︰ Ai Ye ︰ Piao nitre ︰ and passes through the sweet careless ︰ Pericarpium Zanthoxyli of bone grass ︰=3 ︰, 3 ︰, 6 ︰, 5 ︰, 10 ︰, 6 ︰, 3 ︰ 1.
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| CN2011102921981A CN102366573A (en) | 2011-10-02 | 2011-10-02 | Externally applied medicine for treating eczema and preparation method thereof |
| CN 201210287998 CN102755572B (en) | 2011-10-02 | 2012-08-14 | Medicine for external application for treating eczema disease and preparation method thereof |
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| CN105169342A (en) * | 2015-10-12 | 2015-12-23 | 临沂草之美医药科技有限公司 | Traditional Chinese medicine composition for treating eczema and preparation method thereof |
| CN105770839A (en) * | 2015-10-12 | 2016-07-20 | 烟台市蓝洋之草医药生物科技有限公司 | Method for preparing traditional Chinese medicinal composition for treating eczema |
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| CN105079671A (en) * | 2015-08-31 | 2015-11-25 | 颜海 | External-application medicated wine for treating eczema |
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| CN1309400C (en) * | 2004-09-22 | 2007-04-11 | 曾燕 | Chinese medicinal composition for skin caring and its application method |
| CN1778405A (en) * | 2004-11-26 | 2006-05-31 | 鞠文军 | Externally-applied heat-temperature therapeutic health-care bag with Chinese medicine |
| CN101167847B (en) * | 2007-11-13 | 2011-03-16 | 杨春常 | Traditional Chinese medicinal white spirit preparation for effectively treating skin disease |
| CN101579475A (en) * | 2008-05-18 | 2009-11-18 | 尚爱永 | Traditional Chinese medicine for treating eczema |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105169342A (en) * | 2015-10-12 | 2015-12-23 | 临沂草之美医药科技有限公司 | Traditional Chinese medicine composition for treating eczema and preparation method thereof |
| CN105770839A (en) * | 2015-10-12 | 2016-07-20 | 烟台市蓝洋之草医药生物科技有限公司 | Method for preparing traditional Chinese medicinal composition for treating eczema |
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Application publication date: 20120307 |