CN103446369B - Pharmaceutical composition for treating sudden deafness - Google Patents
Pharmaceutical composition for treating sudden deafness Download PDFInfo
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- CN103446369B CN103446369B CN201310361350.6A CN201310361350A CN103446369B CN 103446369 B CN103446369 B CN 103446369B CN 201310361350 A CN201310361350 A CN 201310361350A CN 103446369 B CN103446369 B CN 103446369B
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Abstract
The invention discloses a pharmaceutical composition for treating sudden deafness in order to solve the problem of treatment of sudden deafness. The pharmaceutical composition is characterized by being prepared from the following crude drugs in weight ratio: begonia handelii irmsch., fructus cinnamomi, mosla chinensis maxim, dracocephalum moldavica L., retinervus luffae fructus, medlar, dipsacus asperoides, acorus tatarinowii schott, petals of helianthus annuus L., turbo cornutus solander, bos taurus domesticus gmelin and schefflera arboricola hayata. Clinical experiments prove that the pharmaceutical composition has the characteristic of good curative effect when used for treating sudden deafness, and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to drug world, be specifically related to a kind of pharmaceutical composition for the treatment of sudden deafness.
Background technology
Sudden deafness (sudden deafness), refers to occur, agnogenic Sensorineural hearing loss suddenly.Main clinical manifestation is that Unilateral Hearing declines, can with tinnitus, ear blocking sense, dizzy, Nausea and vomiting etc.
The etiology unknown of sudden deafness, a lot of paathogenic factor all may cause sudden deafness, and mainly contain viral infection theory, circulatory disturbance theory, theory of autoimmunity and the membranous labyrinth that obtain at present extensively accreditation are broken theory etc.In viral infection theory, the acute cochlitis that the cause of disease of sudden deafness may cause for virus or acute cochleovestibular labyrinthitis, at the Etiological that circulatory disturbance theory Middle inner ear blood supply disorder is sudden deafness, theory of autoimmunity is the pathogenesis that sudden deafness is newer.
Sudden deafness treatment is the method adopting Comprehensive Treatment at present more, and effective percentage is about 70%.Start time for the treatment of and prognosis has certain relation, therefore should after morbidity treated as soon as possible in 7-10 days.Glucocorticoid has antiinflammatory, antiviral and immunosuppressant effect, can alleviating vascular endothelium edema, and increasing internal ear blood supply, is the critical treatment of sudden deafness at present.But because Corticosteroids has taboo, and side effect is many, therefore a kind of medicine being specifically designed to sudden deafness of clinical shortage.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the pharmaceutical composition of the little treatment sudden deafness of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition for the treatment of sudden deafness, it is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts, ferrum rice, Fructus cinnamomi immaturus 6 ~ 12 parts, Herba Moslae Chinensis 3 ~ 10 parts, Herba Dracocephali 6 ~ 12 parts, Retinervus Luffae Fructus 3 ~ 10 parts, Fructus Lycii 6 ~ 12 parts, Radix Dipsaci 6 ~ 12 parts, Rhizoma Acori Graminei 6 ~ 12 parts, Flos Helianthi 6 ~ 12 parts, Turbo cornutus Solander 1 ~ 5 part, Os-Medulla Bovis seu Bubali 3 ~ 10 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10 ~ 25 parts.
Chinese medicine of the present invention is prepared from by the raw material of following optimum weight part proportioning: 20 parts, ferrum rice, Fructus cinnamomi immaturus 10 parts, Herba Moslae Chinensis 6 parts, Herba Dracocephali 10 parts, Retinervus Luffae Fructus 6 parts, Fructus Lycii 10 parts, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Os-Medulla Bovis seu Bubali 6 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 20 parts.
Wherein said: ferrum rice is the herb of Begoniaceae plant B. brevicaulis Ku Begonia handelii Irmsch..Bitter in the mouth, cold in nature.Merit can heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling; Promoting digestion and invigorating the stomach.
Fructus cinnamomi immaturus, the tender fruit of the children for canella Cortex Cinnamomi.Gas fragrance, taste is micro-sweet.Nature and flavor Wen Xingan, returns stomach warp.Merit can warming spleen and stomach for dispelling cold.
Herba Moslae Chinensis is the herb of labiate Mosla chinensis Maxim. Bulbophyllum reptans Lindl..Nature and flavor are worked hard, temperature.Merit can be driven away summer heat, and invigorates blood circulation, and regulates the flow of vital energy, removing dampness.
Herba Dracocephali, be Labiatae dragonhead Herba Dracocephali Dracocephalum moldavica L., nature and flavor are pungent, bitter, cool.Merit can be induced sweat in lung heat clearing, cool liver hemostasis.
Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.Merit can dredging collateral, invigorates blood circulation, dispels the wind.
Fructus Lycii is the fruit of Solanaceae Lycium Fructus Lycii Polygonatum kingianum Coll.et Hemsl., and merit can mend marrow, enriching yin and nourishing kidney, benefiting vital QI for tranquillizing by spermatogenesis.
Radix Dipsaci is the dry root of Dipsacaceae herbaceos perennial Radix Dipsaci Himalayan Teasel Root.Bitter in the mouth is pungent; Slightly warm in nature.Return liver, kidney channel.Merit can invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous injured; Only metrorrhagia.
Rhizoma Acori Graminei is the dry rhizome of Rhizoma Acori Graminei Citrus reticulata Blanco, and merit can be whetted the appetite in removing dampness, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.
Flos Helianthi is the flower of feverfew Helianthi Helianthus annuus L..Taste is micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Turbo cornutus Solander, covers operculum for Mollusca Turbinidae Turbo cornulus Turbo cornutus Solander.Salty in the mouth; Property is put down.Return kidney channel.Merit can clearing away damp-heat; Remove phlegm-fire; Separate sore.Taste is micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Os-Medulla Bovis seu Bubali is Artiodactyla Bovidae cattle Bos taurus domesticus Gmelin, is used as medicine with the inner hard bone heart of Cornu Bovis seu Bubali.Nature and flavor are bitter, temperature.Merit can be stopped blooding.
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), is Araliaceae Schefflera plant schefflera arboricola Scheffleva arboricola Hayata and Schefflera venulosa (Wight et Arn.) Harms S.venulosa (Wight et Arn.) Harms, is used as medicine with stem and leaf.Nature and flavor are bitter, sweet, temperature.Merit can pain relieving dissipating blood stasis, detumescence.
Composition principle: the etiology unknown of sudden deafness, a lot of paathogenic factor all may cause sudden deafness, and mainly contain viral infection theory, circulatory disturbance theory, theory of autoimmunity and the membranous labyrinth that obtain at present extensively accreditation are broken theory etc.In viral infection theory, the acute cochlitis that the cause of disease of sudden deafness may cause for virus or acute cochleovestibular labyrinthitis, at the Etiological that circulatory disturbance theory Middle inner ear blood supply disorder is sudden deafness, theory of autoimmunity is the pathogenesis that sudden deafness is newer.Traditional Chinese Medicine is thought, sudden deafness, also known as sudden deafness, mostly is few YANG excess heat, as pointed out " deafness all belongs to heat " in " danxi's experiential therapy is deaf ", and thinking that few sun is fainted cloudy ill and deaf, is also heat in blood, also have YIN-fire dynamic and deaf, evil fire-transformation and deafness etc., even if deuteropathic deafness also answers pathogenic fire reducing greatly.This kind of rule for the treatment of is consistent with viral theory, but numerous known, and sudden deafness pathogenic factor is various, and viral infection is only a kind of cause of disease, so, to relieve inflammation or internal heat as the Modified Minor Decoction of Bupleurum curative effect of the rule for the treatment of is not high.
Inventor's clinical research for many years finds, the generation of sudden deafness is relevant with meridians insubstantial phlegm, when expectorant agglutinate poly-to a certain extent time, endogenous fire disturbance and sick.Relieve inflammation or internal heat merely, though can deal with problems for the moment, but expectorant is solidifying not to be gone, and is easy to recurrence.And the expectorant of all meridians, the institute of lid and Tianjin blood, and solely attack its expectorant, then Tianjin blood is hindered again, and vigour more exhausts, and with going with change, expectorant must be more.Be that event we avoid using eliminating phlegm eliminating stagnation medicine, its reason is that meridians stagnation of phlegm is different from visible phlegm, inventor's clinical experience gained: use such medicine, and meridians conduction irritability, easily causes the untoward reaction such as chronic pain and acoustic nerve abnormal reflection.
Compared with prior art, the present invention has following characteristics.
1, ferrum rice and Fructus cinnamomi immaturus coordinate for monarch drug, and inventor studies discovery: ferrum rice is cold sliding, clearing away phlegm pathogenic fire reducing, the expectorant that network of passing through, flesh side, film are outer, use same with Fructus cinnamomi immaturus, make warm its warp solid of Fructus cinnamomi immaturus, and cold its network logical of ferrum rice, the two sweet cold taste brings out the best in each other, indispensable.Do not have the cooperation of Fructus cinnamomi immaturus Wen Hanggu warp, and solely attack its expectorant, then Tianjin blood is hindered again, and vigour more exhausts, and with going with change, expectorant must be more.In fire-clearing medicament, add the Fructus cinnamomi immaturus having Wen Tonggu through effect, be the maximum feature of this prescription.
2, Herba Moslae Chinensis dehumidifying is regulated the flow of vital energy, and Herba Dracocephali dredging collateral is subsided a swelling, and this two medicine is the medicine that the assistant of ferrum rice helps.
3, Fructus Lycii enriching yin and nourishing kidney, Radix Dipsaci nourishing the liver and kidney, Rhizoma Acori Graminei removing dampness is whetted the appetite, reinforcing Guyuan, eliminates the inherent cause of disease of sudden deafness from source.
4, Retinervus Luffae Fructus is invigorated blood circulation motionless blood, and has the strong muscle effect of dredging collateral, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) dissipating blood stasis for subsidence of swelling, this two medicines topical application can alleviate cochlea local microcirculation obstacle, excited acoustic nerve and ear cells, promote the biological activity of internal ear neutral net, dredge the sering of inaccessible stasis blocking.
5, Turbo cornutus Solander, Flos Helianthi dispel the wind suppressing the hyperactive liver dampness removing, eliminate the external cause of disease of sudden deafness.
6, inventor's experimentation shows: low dose of Turbo cornutus Solander can increase local skin permeability effectively.
7, in one row falls apart dredging collateral medicine, add low dose of Os-Medulla Bovis seu Bubali, play assistant and make use, Kai Heyou road, reduce side effect.
8, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: 20 parts, ferrum rice, Fructus cinnamomi immaturus 10 parts, Herba Moslae Chinensis 6 parts, Herba Dracocephali 10 parts, Retinervus Luffae Fructus 6 parts, Fructus Lycii 10 parts, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Os-Medulla Bovis seu Bubali 6 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 20 parts.
The preparation method of embodiment 1 is: ferrum rice, Fructus cinnamomi immaturus, Herba Moslae Chinensis, Herba Dracocephali, Retinervus Luffae Fructus, Fructus Lycii, Radix Dipsaci, Rhizoma Acori Graminei, Flos Helianthi, Turbo cornutus Solander, Os-Medulla Bovis seu Bubali, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate is merged into decoction.
Embodiment 2, crude drug weight proportion: 10 parts, ferrum rice, Fructus cinnamomi immaturus 6 parts, Herba Moslae Chinensis 3 parts, Herba Dracocephali 6 parts, Retinervus Luffae Fructus 3 parts, Fructus Lycii 6 parts, Radix Dipsaci 6 parts, Rhizoma Acori Graminei 6 parts, Flos Helianthi 6 parts, Turbo cornutus Solander 1 part, Os-Medulla Bovis seu Bubali 3 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10 parts.
Embodiment 3, crude drug weight proportion: 20 parts, ferrum rice, Fructus cinnamomi immaturus 10 parts, Herba Moslae Chinensis 6 parts, Herba Dracocephali 10 parts, Retinervus Luffae Fructus 6 parts, Fructus Lycii 10 parts, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Os-Medulla Bovis seu Bubali 6 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 20 parts.
Embodiment 4, crude drug weight proportion: 30 parts, ferrum rice, Fructus cinnamomi immaturus 12 parts, Herba Moslae Chinensis 10 parts, Herba Dracocephali 12 parts, Retinervus Luffae Fructus 10 parts, Fructus Lycii 12 parts, Radix Dipsaci 12 parts, Rhizoma Acori Graminei 12 parts, Flos Helianthi 12 parts, Turbo cornutus Solander 5 parts, Os-Medulla Bovis seu Bubali 10 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Radix Dipsaci, Fructus cinnamomi immaturus, Retinervus Luffae Fructus coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, Os-Medulla Bovis seu Bubali are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) ferrum rice, Herba Moslae Chinensis, Herba Dracocephali, Fructus Lycii, Flos Helianthi, Rhizoma Acori Graminei, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) are decocted with water 2 times, filter, merging filtrate, it is 1.20(50 DEG C that filtrate is concentrated into relative density), adding ethanol makes alcohol content be 60%, leaves standstill and makes precipitation, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) fine powder of the volatile oil of step 1 gained, step 2 gained is added the thick paste of step 3 gained, stir, dry, pulverize, cross 100 mesh sieves, to obtain final product.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
The efficient combination of said medicine, coordinates mutually, and effectively reach the object for the treatment of sudden deafness, the above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: choose in March, 2012 ~ 2013 patients with sudden sensorineural hearing loss 90 example in year March.Inclusion criteria: allly occur suddenly auditory dysesthesia or auditory dysesthesia companion tinnitus, the symptom such as dizzy, through clinical examination, pure tone electric audiometry, acoustic immitance, vestibular function and iconography (head and lnner stripe CT) check, get rid of central neuropathy, according to the standard that Chinese Medical Association ENT & HN Surgery Dept. credit in 2005 can be formulated in Jinan, the person that is diagnosed as sudden deafness.Exclusion standard: 1. through extramural hospital treatment person, 2. auditory dysesthesia person, 3. age > 65 years old person, 4. disease time > 14d person in the past.
1.1.2 divide into groups: adopt simple randomized grouping to design, often organize each 30 examples.Matched group: man 16 example, female 14 example, 12 ~ 63 years old age, average 41 years old.Monaural 28 example, ears 2 example.Deafness: slight (26 ~ 40dB) 8 is routine; Moderate (41 ~ 55dB) 9 example; Middle severe (56 ~ 70dB) 8 example; Severe (71 ~ 90dB) 4 example; Pole severe (> 90dB) 1 example.The average threshold of audibility (72.36 ± 17.52) dB before treatment.Ion-transmission group: man 18 example, female 12 example, 20 ~ 57 years old age, average 45 years old.Monaural 24 example, ears 6 example.Deafness: slight 9 examples, moderate 9 example, middle severe 5 example, severe 6 example, pole severe 1 example.The average threshold of audibility (71.38 ± 19.14) dB before treatment, acupuncture point dresses group: man 17 example, female 13 example, 20 ~ 60 years old age, average 42 years old.Monaural 26 example, ears 4 example.Deafness: slight 10 examples, moderate 7 example, middle severe 7 example, severe 5 example, pole severe 1 example.The average threshold of audibility (72.23 ± 18.14) dB before treatment, three groups through statistical analysis, the difference of age, sex, the state of an illness does not have statistical significance (P>0.05), has comparability.
1.2 method.
1.2.1 administering mode: matched group: oral methylcobalamin tablet 0.5 ~ 1mg, 1 time/d.Ion-transmission group: adopt the embodiment of the present invention 1 gained decoction capable ion-transmission of nebula wind scoop after point gb 2 and ear before ear.Acupuncture point dresses group: dress the embodiment of the present invention 3 gained powder before ear after (side door, Tinggong, be a visitor at a meeting) and ear (nebula wind, Chi arteries and veins, Luxi) with mature vinegar.Ion-transmission group and acupuncture point dress treatment equal every day 2 times of group, three groups equal 14 days be 1 course for the treatment of.
1.2.2 curative effect determinate standard: recovery from illness: each frequency threshold of audibility of 0.25 ~ 4 kHz returns to normally, or reaches strong ear level, or reach this time ill front level.Effective: the average audition of said frequencies improves 30 more than dB.Effective: the average audition of said frequencies improves 15 ~ 30 dB.Invalid: the average hearing improved of said frequencies is less than 15 dB.
2 results.
Three groups of curative effects after 1 course of therapy: matched group 30 example is after 1 course of therapy, and recovery from illness 5 example, accounts for 16.7%; Effective 9 examples, account for 30%; Effective 5 examples, account for 16.7%; Invalid 11 examples, account for 36.7%, total effective rate 63.3%.Ion-transmission group 30 example is after 1 course of therapy, and recovery from illness 16 example, accounts for 53.3%; Effective 8 examples, account for 26.7%; Effective 4 examples, account for 13.3%; Invalid 2 examples, account for 6.7%, total effective rate 93.3%.Acupuncture point dresses group 30 example after 1 course of therapy, and recovery from illness 17 example, accounts for 56.7%; Effective 7 examples, account for 23.3%; Effective 3 examples, account for 10%; Invalid 3 examples, account for 10%, total effective rate 90%.
3. conclusion.
The display of this result of study, applies ear acupuncture point ion-transmission of the present invention or powder dresses, and effectively can treat sudden deafness, cure rate and total effective rate are apparently higher than matched group (P<0.05).
Claims (2)
1. treat a pharmaceutical composition for sudden deafness, it is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts, ferrum rice, Fructus cinnamomi immaturus 6 ~ 12 parts, Herba Moslae Chinensis 3 ~ 10 parts, Herba Dracocephali 6 ~ 12 parts, Retinervus Luffae Fructus 3 ~ 10 parts, Fructus Lycii 6 ~ 12 parts, Radix Dipsaci 6 ~ 12 parts, Rhizoma Acori Graminei 6 ~ 12 parts, Flos Helianthi 6 ~ 12 parts, Turbo cornutus Solander 1 ~ 5 part, Os-Medulla Bovis seu Bubali 3 ~ 10 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10 ~ 25 parts.
2. a kind of pharmaceutical composition for the treatment of sudden deafness according to claim 1, is characterized in that being prepared from by the crude drug of following weight proportion: 20 parts, ferrum rice, Fructus cinnamomi immaturus 10 parts, Herba Moslae Chinensis 6 parts, Herba Dracocephali 10 parts, Retinervus Luffae Fructus 6 parts, Fructus Lycii 10 parts, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Os-Medulla Bovis seu Bubali 6 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 20 parts.
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| CN201310361350.6A CN103446369B (en) | 2013-08-19 | 2013-08-19 | Pharmaceutical composition for treating sudden deafness |
| CN201510343258.6A CN104983958A (en) | 2013-08-19 | 2013-08-19 | Preparation method for sudden deafness iontophoresis drug |
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| CN201310361350.6A CN103446369B (en) | 2013-08-19 | 2013-08-19 | Pharmaceutical composition for treating sudden deafness |
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