CN103446369A - Pharmaceutical composition for treating sudden deafness - Google Patents
Pharmaceutical composition for treating sudden deafness Download PDFInfo
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- CN103446369A CN103446369A CN2013103613506A CN201310361350A CN103446369A CN 103446369 A CN103446369 A CN 103446369A CN 2013103613506 A CN2013103613506 A CN 2013103613506A CN 201310361350 A CN201310361350 A CN 201310361350A CN 103446369 A CN103446369 A CN 103446369A
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Abstract
The invention discloses a pharmaceutical composition for treating sudden deafness in order to solve the problem of preoperative treatment of a gynecological operation. The pharmaceutical composition is characterized by being prepared from the following crude drugs in weight ratio: begonia handelii irmsch., fructus cinnamomi, mosla chinensis maxim, dracocephalum moldavica L., retinervus luffae fructus, medlar, dipsacus asperoides, acorus tatarinowii schott, petals of helianthus annuus L., turbo cornutus solander, bos taurus domesticus gmelin and schefflera arboricola hayata. Clinical experiments prove that the pharmaceutical composition has the characteristic of good curative effect when used for treating sudden deafness, and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to drug world, be specifically related to a kind of pharmaceutical composition for the treatment of sudden deafness.
Background technology
Sudden deafness (sudden deafness), refer to unexpected generation, agnogenic Sensorineural hearing loss.Main clinical manifestation is that Unilateral Hearing descends, and can stop up sense, dizzy, nauseating, vomiting etc. with tinnitus, ear.
The etiology unknown of sudden deafness, a lot of paathogenic factors all may cause sudden deafness, and what obtain at present extensively approval mainly contains viral infection theory, circulatory disturbance theory, theory of autoimmunity and the membranous labyrinth theory etc. of breaking.In the viral infection theory, acute cochlitis or acute cochlea vestibular labyrinth inflammation that the cause of disease of sudden deafness may cause for virus, in the circulatory disturbance theory, blood supply disturbance of internal ear is the Etiological of sudden deafness, and theory of autoimmunity is the pathogenesis that sudden deafness is newer.
The sudden deafness treatment is the methods that adopt Comprehensive Treatment at present more, and effective percentage is in 70% left and right.The time of begin treatment and prognosis have certain relation, therefore should treatment as early as possible in 7-10 days after morbidity.Glucocorticoid has antiinflammatory, antiviral and immunosuppressant effect, but the alleviating vascular endothelium edema increases the internal ear blood supply, is the critical treatment of sudden deafness at present.But because Corticosteroids has taboo, and side effect is many, therefore a kind of medicine that is specifically designed to sudden deafness of clinical shortage.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the pharmaceutical composition of the treatment sudden deafness that side effect is little.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition for the treatment of sudden deafness is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts, ferrum rice, 6 ~ 12 parts of Fructus cinnamomi immaturus, 3 ~ 10 parts of Herba Moslae Chinensis, 6 ~ 12 parts of Herba Dracocephalis, 3 ~ 10 parts of Retinervus Luffae Fructuss, 6 ~ 12 parts of Fructus Lycii, 6 ~ 12 parts of Radix Dipsaci, 6 ~ 12 parts of Rhizoma Acori Graminei, 6 ~ 12 parts of Flos Helianthis, 1 ~ 5 part of Turbo cornutus Solander, 3 ~ 10 parts, the Cornu Bovis seu Bubali cheek, 10 ~ 25 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s.
Chinese medicine of the present invention is that the raw material by following optimum weight part proportioning is prepared from: 20 parts, ferrum rice, 10 parts of Fructus cinnamomi immaturus, 6 parts of Herba Moslae Chinensis, 10 parts of Herba Dracocephalis, 6 parts of Retinervus Luffae Fructuss, 10 parts of Fructus Lycii, 10 parts of Radix Dipsaci, 10 parts of Rhizoma Acori Graminei, 10 parts of Flos Helianthis, 2 parts of Turbo cornutus Solander, 6 parts, the Cornu Bovis seu Bubali cheek, 20 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s.
Wherein said: ferrum rice is the herb of Begoniaceae plant B. brevicaulis Ku Begonia handelii Irmsch..Bitter in the mouth, cold in nature.But merit heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling; Promoting digestion and invigorating the stomach.
Fructus cinnamomi immaturus is the tender fruit of the children of canella Cortex Cinnamomi.Gas fragrance, distinguish the flavor of micro-sweet.Nature and flavor Wen Xingan, return the stomach warp.But merit warming spleen and stomach for dispelling cold.
Herba Moslae Chinensis is the herb of labiate Mosla chinensis Maxim. Bulbophyllum reptans Lindl..Nature and flavor are arduous, temperature.Merit can be driven away summer heat, and invigorates blood circulation, regulate the flow of vital energy, and removing dampness.
Herba Dracocephali, be Labiatae dragonhead Herba Dracocephali Dracocephalum moldavica L., and nature and flavor are hot, bitter, cool.But the merit lung heat clearing is induced sweat, cool liver hemostasis.
Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.But the merit dredging collateral, invigorate blood circulation, and dispels the wind.
The fruit that Fructus Lycii is Solanaceae Lycium Fructus Lycii Polygonatum kingianum Coll.et Hemsl., but the merit spermatogenesis is mended marrow, enriching yin and nourishing kidney, benefiting vital QI for tranquillizing.
Radix Dipsaci is the dry root of Dipsacaceae herbaceos perennial Radix Dipsaci Himalayan Teasel Root.The bitter in the mouth suffering; Slightly warm in nature.Return liver, kidney channel.But merit invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous folding wound; Only metrorrhagia.
Rhizoma Acori Graminei, be the dry rhizome of Rhizoma Acori Graminei Citrus reticulata Blanco, but merit removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.
Flos Helianthi is the flower of feverfew Helianthi Helianthus annuus L..Distinguish the flavor of micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Turbo cornutus Solander is the operculum of covering of Mollusca Turbinidae Turbo cornulus Turbo cornutus Solander.Salty in the mouth; Property is put down.Return kidney channel.But merit clearing away damp-heat; Remove phlegm-fire; Separate sore.Distinguish the flavor of micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
The Cornu Bovis seu Bubali cheek, be Artiodactyla Bovidae cattle Bos taurus domesticus Gmelin, with the inner hard bone heart of Cornu Bovis seu Bubali, is used as medicine.The nature and flavor hardship, temperature.Merit can be stopped blooding.
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), for Araliaceae Schefflera plant schefflera arboricola Scheffleva arboricola Hayata and Schefflera venulosa (Wight et Arn.) Harms S.venulosa (Wight et Arn.) Harms, be used as medicine with stem and leaf.Nature and flavor are bitter, sweet, temperature.But merit pain relieving dissipating blood stasis, detumescence.
Composition principle: the etiology unknown of sudden deafness, a lot of paathogenic factors all may cause sudden deafness, and what obtain at present extensively approval mainly contains viral infection theory, circulatory disturbance theory, theory of autoimmunity and the membranous labyrinth theory etc. of breaking.In the viral infection theory, acute cochlitis or acute cochlea vestibular labyrinth inflammation that the cause of disease of sudden deafness may cause for virus, in the circulatory disturbance theory, blood supply disturbance of internal ear is the Etiological of sudden deafness, and theory of autoimmunity is the pathogenesis that sudden deafness is newer.Traditional Chinese Medicine is thought, sudden deafness claims again sudden deafness, mostly is few YANG excess heat, as pointed out in " danxi's experiential therapy deafness " " deafness all belongs to heat ", and thinking that few sun faints cloudy illly and deaf, is also heat in blood, also have YIN-fire moving and deaf, evil fire-transformation and deaf etc., even deafness is also answered pathogenic fire reducing greatly after being ill.This kind of rule for the treatment of is consistent with viral theory, but numerous known, and the sudden deafness pathogenic factor is various, and viral infection is only a kind of cause of disease, so the Modified Minor Decoction of Bupleurum curative effect of relieving inflammation or internal heat as the rule for the treatment of of take is not high.
Inventor's clinical research for many years finds, the generation of sudden deafness is relevant with the meridians insubstantial phlegm, when expectorant agglutinate poly-to a certain extent the time, endogenous fire disturbance and sick.Relieve inflammation or internal heat merely, though can deal with problems for the moment, do not go but expectorant is solidifying, be easy to recurrence.And the expectorant of all meridians, lid is the institute of Tianjin blood, and solely attacks its expectorant, and Tianjin blood is hindered again, and vigour more exhausts, and with going with change, expectorant must be more.Hereat we avoid using eliminating phlegm eliminating stagnation medicine, and its reason is that the meridians stagnation of phlegm is different from visible phlegm, inventor's clinical experience gained: use such medicine, meridians conduction irritability, easily cause the untoward reaction such as chronic pain and acoustic nerve abnormal reflection.
Compared with prior art, the present invention has following characteristics.
1, ferrum rice and Fructus cinnamomi immaturus coordinate for monarch drug, and the inventor studies discovery: ferrum rice is cold sliding, the clearing away phlegm pathogenic fire reducing, and the network of passing through, flesh side, the outer expectorant of film, with the same use of Fructus cinnamomi immaturus, make warm solid its warp of Fructus cinnamomi immaturus, cold logical its network of ferrum rice, the two sweet cold flavor brings out the best in each other, indispensable.There is no the cooperation of Fructus cinnamomi immaturus Wen Hanggu warp, and solely attack its expectorant, Tianjin blood is hindered again, and vigour more exhausts, and with going with change, expectorant must be more.Adding in fire-clearing medicament the Fructus cinnamomi immaturus of Wen Tonggu through effect arranged, is the maximum characteristics of this prescription.
2, the Herba Moslae Chinensis dehumidifying is regulated the flow of vital energy, the detumescence of Herba Dracocephali dredging collateral, the medicine that the assistant that this two medicine is ferrum rice helps.
3, Fructus Lycii enriching yin and nourishing kidney, the Radix Dipsaci nourishing the liver and kidney, Rhizoma Acori Graminei removing dampness appetizing, the reinforcing Guyuan, from the inherent cause of disease of source elimination sudden deafness.
4, the Retinervus Luffae Fructus motionless blood of invigorating blood circulation, and the strong muscle effect of dredging collateral, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) dissipating blood stasis for subsidence of swelling are arranged, this section of two officinas application can be alleviated cochlea local microcirculation obstacle, excited acoustic nerve and interior ear cell, promote the biological activity of internal ear neutral net, dredges the sering of inaccessible stasis blocking.
5, Turbo cornutus Solander, the Flos Helianthi suppressing the hyperactive liver dampness removing that dispels the wind, eliminate the external cause of disease of sudden deafness.
6, inventor's experimentation shows: low dose of Turbo cornutus Solander can increase the local skin permeability effectively.
7, add the low dose of Cornu Bovis seu Bubali cheek in the loose dredging collateral medicine of one row, play assistant and make use, the Kai Heyou road, reduce side effect.
8, medicine material consumption of the present invention is groped in a large number to sum up through the inventor and is drawn, each raw material consumption is for all to have curative effect preferably in the following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: 20 parts, ferrum rice, 10 parts of Fructus cinnamomi immaturus, 6 parts of Herba Moslae Chinensis, 10 parts of Herba Dracocephalis, 6 parts of Retinervus Luffae Fructuss, 10 parts of Fructus Lycii, 10 parts of Radix Dipsaci, 10 parts of Rhizoma Acori Graminei, 10 parts of Flos Helianthis, 2 parts of Turbo cornutus Solander, 6 parts, the Cornu Bovis seu Bubali cheek, 20 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s.
The preparation method of embodiment 1 is: ferrum rice, Fructus cinnamomi immaturus, Herba Moslae Chinensis, Herba Dracocephali, Retinervus Luffae Fructus, Fructus Lycii, Radix Dipsaci, Rhizoma Acori Graminei, Flos Helianthi, Turbo cornutus Solander, the Cornu Bovis seu Bubali cheek, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) mixing and water adding are decocted, get filtrate after 30 minutes, medicinal residues add water continuation decoction and get filtrate after 20 minutes, and twice filtrate is merged into decoction.
Embodiment 2, the crude drug weight proportion: 10 parts, ferrum rice, 6 parts of Fructus cinnamomi immaturus, 3 parts of Herba Moslae Chinensis, 6 parts of Herba Dracocephalis, 3 parts of Retinervus Luffae Fructuss, 6 parts of Fructus Lycii, 6 parts of Radix Dipsaci, 6 parts of Rhizoma Acori Graminei, 6 parts of Flos Helianthis, 1 part of Turbo cornutus Solander, 3 parts, the Cornu Bovis seu Bubali cheek, 10 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s.
Embodiment 3, the crude drug weight proportion: 20 parts, ferrum rice, 10 parts of Fructus cinnamomi immaturus, 6 parts of Herba Moslae Chinensis, 10 parts of Herba Dracocephalis, 6 parts of Retinervus Luffae Fructuss, 10 parts of Fructus Lycii, 10 parts of Radix Dipsaci, 10 parts of Rhizoma Acori Graminei, 10 parts of Flos Helianthis, 2 parts of Turbo cornutus Solander, 6 parts, the Cornu Bovis seu Bubali cheek, 20 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s.
Embodiment 4, the crude drug weight proportion: 30 parts, ferrum rice, 12 parts of Fructus cinnamomi immaturus, 10 parts of Herba Moslae Chinensis, 12 parts of Herba Dracocephalis, 10 parts of Retinervus Luffae Fructuss, 12 parts of Fructus Lycii, 12 parts of Radix Dipsaci, 12 parts of Rhizoma Acori Graminei, 12 parts of Flos Helianthis, 5 parts of Turbo cornutus Solander, 10 parts, the Cornu Bovis seu Bubali cheek, 25 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Radix Dipsaci, Fructus cinnamomi immaturus, Retinervus Luffae Fructus coarse powder are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, the Cornu Bovis seu Bubali cheek were pulverized to 150 mesh sieves, and became fine powder standby;
(3) ferrum rice, Herba Moslae Chinensis, Herba Dracocephali, Fructus Lycii, Flos Helianthi, Rhizoma Acori Graminei, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) are decocted with water 2 times, filter, merging filtrate, it is 1.20(50 ℃ that filtrate is concentrated into relative density), adding ethanol, to make containing alcohol amount be 60%, and the standing precipitation that makes, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) fine powder of the volatile oil of step 1 gained, step 2 gained is added to the thick paste of step 3 gained, stir, dry, pulverize, cross 100 mesh sieves, obtain.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
Effective combination of said medicine, coordinate mutually, effectively reaches the purpose for the treatment of sudden deafness, and the above results is the clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case is selected: choose in March, 2012 ~ 2013 patients with sudden sensorineural hearing loss 90 examples in year March.Inclusion criteria: all auditory dysesthesia or auditory dysesthesia companion tinnitus, symptoms such as dizzy of occurring suddenly, through clinical examination, pure tone electric audiometry, acoustic immitance, vestibular function and iconography (head and interior auditory canal CT) check, get rid of central neuropathy, the standard of formulating in Jinan according to Chinese Medical Association's ENT & HN Surgery Dept. credit meeting in 2005, the person that is diagnosed as the sudden deafness.Exclusion standard: 1. through extramural hospital treatment person, 2. auditory dysesthesia person, 3. age>65 year old person, 4. disease time>14d person in the past.
1.1.2 grouping: adopt simple randomized grouping design, every group of each 30 examples.Matched group: male 16 examples, female's 14 examples, 12～63 years old age, average 41 years old.Monaural 28 examples, ears 2 examples.Deafness: slight (26～40dB) 8 examples; Moderate (41～55dB) 9 examples; Middle severe (56～70dB) 8 examples; Severe (71～90dB) 4 examples; Utmost point severe (>90dB) 1 example.The average threshold of audibility (72.36 ± 17.52) dB before treatment.Ion-transmission group: male 18 examples, female's 12 examples, 20～57 years old age, average 45 years old.Monaural 24 examples, ears 6 examples.Deafness: slight 9 examples, moderate 9 examples, middle severe 5 examples, severe 6 examples, utmost point severe 1 example.The average threshold of audibility (71.38 ± 19.14) dB before treatment, acupuncture point dresses group: male 17 examples, female's 13 examples, 20～60 years old age, average 42 years old.Monaural 26 examples, ears 4 examples.Deafness: slight 10 examples, moderate 7 examples, middle severe 7 examples, severe 5 examples, utmost point severe 1 example.The average threshold of audibility (72.23 ± 18.14) dB before treatment, three groups of Epidemiological Analysis by statistics, the difference of age, sex, the state of an illness does not have statistical significance (P > 0.05), has comparability.
1.2 method.
1.2.1 administering mode: matched group: oral methylcobalamin tablet 0.5 ~ 1mg, 1 time/d.Ion-transmission group: adopt the embodiment of the present invention 1 gained decoction capable ion-transmission of nebula wind scoop after point gb 2 and ear before ear.Acupuncture point dresses group: with mature vinegar, dress the embodiment of the present invention 3 gained powders before ear after (side door, Tinggong, be a visitor at a meeting) and ear (nebula wind, Chi arteries and veins, Luxi).Ion-transmission group and acupuncture point dress treatment equal every day 2 times of group, three groups equal 14 days be 1 course for the treatment of.
1.2.2 curative effect determinate standard: recovery from illness: each frequency threshold of audibility of 0.25～4 kHz returns to normally, or reaches strong ear level, or reaches this time ill front level.Produce effects: more than the average audition of said frequencies improves 30 dB.Effectively: the average audition of said frequencies improves 15～30 dB.Invalid: average hearing improved less than 15 dB of said frequencies.
2 results.
Through three groups of curative effects after 1 course of therapy: matched group 30 examples are after 1 course of therapy, and 5 examples of fully recovering, account for 16.7%; Produce effects 9 examples, account for 30%; Effective 5 examples, account for 16.7%; Invalid 11 examples, account for 36.7%, total effective rate 63.3%.Ion-transmission group 30 examples are after 1 course of therapy, and 16 examples of fully recovering, account for 53.3%; Produce effects 8 examples, account for 26.7%; Effective 4 examples, account for 13.3%; Invalid 2 examples, account for 6.7%, total effective rate 93.3%.Acupuncture point dresses group 30 examples after 1 course of therapy, and 17 examples of fully recovering, account for 56.7%; Produce effects 7 examples, account for 23.3%; Effective 3 examples, account for 10%; Invalid 3 examples, account for 10%, total effective rate 90%.
3. conclusion.
This result of study shows, applies ear of the present invention acupuncture point ion-transmission or powder and dresses, and can effectively treat sudden deafness, and cure rate and total effective rate are apparently higher than matched group (P<0.05).
Claims (2)
1. a pharmaceutical composition for the treatment of sudden deafness, is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts, ferrum rice, 6 ~ 12 parts of Fructus cinnamomi immaturus, 3 ~ 10 parts of Herba Moslae Chinensis, 6 ~ 12 parts of Herba Dracocephalis, 3 ~ 10 parts of Retinervus Luffae Fructuss, 6 ~ 12 parts of Fructus Lycii, 6 ~ 12 parts of Radix Dipsaci, 6 ~ 12 parts of Rhizoma Acori Graminei, 6 ~ 12 parts of Flos Helianthis, 1 ~ 5 part of Turbo cornutus Solander, 3 ~ 10 parts, the Cornu Bovis seu Bubali cheek, 10 ~ 25 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s.
2. a kind of pharmaceutical composition for the treatment of sudden deafness according to claim 1, is characterized in that being prepared from by the crude drug of following weight proportion: 20 parts, ferrum rice, 10 parts of Fructus cinnamomi immaturus, 6 parts of Herba Moslae Chinensis, 10 parts of Herba Dracocephalis, 6 parts of Retinervus Luffae Fructuss, 10 parts of Fructus Lycii, 10 parts of Radix Dipsaci, 10 parts of Rhizoma Acori Graminei, 10 parts of Flos Helianthis, 2 parts of Turbo cornutus Solander, 6 parts, the Cornu Bovis seu Bubali cheek, 20 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s.
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| CN201510343258.6A CN104983958A (en) | 2013-08-19 | 2013-08-19 | Preparation method for sudden deafness iontophoresis drug |
| CN201310361350.6A CN103446369B (en) | 2013-08-19 | 2013-08-19 | Pharmaceutical composition for treating sudden deafness |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104825890A (en) * | 2015-05-19 | 2015-08-12 | 李玉芬 | Traditional Chinese medicine for treating wind-fire pathogen type sudden deafness and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104825890A (en) * | 2015-05-19 | 2015-08-12 | 李玉芬 | Traditional Chinese medicine for treating wind-fire pathogen type sudden deafness and preparation method |
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