CN103417771B - External TCM drug for treatment of sudden hearing loss - Google Patents
External TCM drug for treatment of sudden hearing loss Download PDFInfo
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- CN103417771B CN103417771B CN201310361372.2A CN201310361372A CN103417771B CN 103417771 B CN103417771 B CN 103417771B CN 201310361372 A CN201310361372 A CN 201310361372A CN 103417771 B CN103417771 B CN 103417771B
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Abstract
The invention discloses external TCM drug for the treatment of sudden hearing loss and solves the problems in the treatment of sudden hearing loss. The external TCM drug is characterized by being prepared with, by weight, all-grass of Begonia sinobrevicaulis, immature fruit of cassiabarktree, Chinese mosla herb, herb of moldavica dragonhead, Chinese honeylocust spine, wolfberry fruit, dipsacus root, grassleaf sweelflag rhizome, sunflower flower, turbo cornutus solander, ox horn bone and common bluebeard herb. Clinical experiments show that the external TCM drug has good effect in treating sudden hearing loss and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to drug world, be specifically related to a kind of external application Chinese medicine for the treatment of sudden hearing disability.
Background technology
Sudden hearing disability (sudden hearing loss), refers to occur, agnogenic Sensorineural hearing loss suddenly.Main clinical manifestation is that Unilateral Hearing declines, can with tinnitus, ear blocking sense, dizzy, Nausea and vomiting etc.Its etiology unknown, a lot of paathogenic factor all may cause sudden hearing disability, and mainly contain viral infection theory, circulatory disturbance theory, theory of autoimmunity and the membranous labyrinth that obtain at present extensively accreditation are broken theory etc.In viral infection theory, the acute cochlitis that the cause of disease of sudden hearing disability may cause for virus or acute cochleovestibular labyrinthitis, at the Etiological that circulatory disturbance theory Middle inner ear blood supply disorder is sudden hearing disability, theory of autoimmunity is the pathogenesis that sudden hearing disability is newer.
The sudden hearing disability treatment method adopting Comprehensive Treatment at present, effective percentage is about 70% more.Start time for the treatment of and prognosis has certain relation, therefore should after morbidity treated as soon as possible in 7-10 days.Glucocorticoid has antiinflammatory, antiviral and immunosuppressant effect, can alleviating vascular endothelium edema, and increasing internal ear blood supply, is the critical treatment of sudden hearing disability at present.But because Corticosteroids has taboo, and side effect is many, therefore a kind of medicine being specifically designed to sudden hearing disability of clinical shortage.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the external application Chinese medicine of the little sudden hearing disability for the treatment of of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of external application Chinese medicine for the treatment of sudden hearing disability, it is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts, ferrum rice, Fructus cinnamomi immaturus 6 ~ 12 parts, Herba Moslae Chinensis 3 ~ 10 parts, Herba Dracocephali 6 ~ 12 parts, Spina Gleditsiae 3 ~ 10 parts, Fructus Lycii 6 ~ 12 parts, Radix Dipsaci 6 ~ 12 parts, Rhizoma Acori Graminei 6 ~ 12 parts, Flos Helianthi 6 ~ 12 parts, Turbo cornutus Solander 1 ~ 5 part, Os-Medulla Bovis seu Bubali 3 ~ 10 parts, Herba Caryopteridis Incanae 10 ~ 25 parts.
Chinese medicine of the present invention is prepared from by the raw material of following optimum weight part proportioning: 20 parts, ferrum rice, Fructus cinnamomi immaturus 10 parts, Herba Moslae Chinensis 6 parts, Herba Dracocephali 10 parts, Spina Gleditsiae 6 parts, Fructus Lycii 10 parts, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Os-Medulla Bovis seu Bubali 6 parts, Herba Caryopteridis Incanae 20 parts.
Wherein said: ferrum rice is the herb of Begoniaceae plant B. brevicaulis Ku Begonia handelii Irmsch..Bitter in the mouth, cold in nature.Merit can heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling; Promoting digestion and invigorating the stomach.
Fructus cinnamomi immaturus, the tender fruit of the children for canella Cortex Cinnamomi.Gas fragrance, taste is micro-sweet.Nature and flavor Wen Xingan, returns stomach warp.Merit can warming spleen and stomach for dispelling cold.
Herba Moslae Chinensis is the herb of labiate Mosla chinensis Maxim. Bulbophyllum reptans Lindl..Nature and flavor are worked hard, temperature.Merit can be driven away summer heat, and invigorates blood circulation, and regulates the flow of vital energy, removing dampness.
Herba Dracocephali, be Labiatae dragonhead Herba Dracocephali Dracocephalum moldavica L., nature and flavor are pungent, bitter, cool.Merit can be induced sweat in lung heat clearing, cool liver hemostasis.
Spina Gleditsiae is the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Nature and flavor are pungent, temperature.Return liver, stomach warp.Merit can be subsided a swelling poison holding, evacuation of pus, parasite killing.
Fructus Lycii is the fruit of Solanaceae Lycium Fructus Lycii Polygonatum kingianum Coll.et Hemsl., and merit can mend marrow, enriching yin and nourishing kidney, benefiting vital QI for tranquillizing by spermatogenesis.
Radix Dipsaci is the dry root of Dipsacaceae herbaceos perennial Radix Dipsaci Himalayan Teasel Root.Bitter in the mouth is pungent; Slightly warm in nature.Return liver, kidney channel.Merit can invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous injured; Only metrorrhagia.
Rhizoma Acori Graminei is the dry rhizome of Rhizoma Acori Graminei Citrus reticulata Blanco, and merit can be whetted the appetite in removing dampness, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.
Flos Helianthi is the flower of feverfew Helianthi Helianthus annuus L..Taste is micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Turbo cornutus Solander, covers operculum for Mollusca Turbinidae Turbo cornulus Turbo cornutus Solander.Salty in the mouth; Property is put down.Return kidney channel.Merit can clearing away damp-heat; Remove phlegm-fire; Separate sore.Taste is micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Os-Medulla Bovis seu Bubali is Artiodactyla Bovidae cattle Bos taurus domesticus Gmelin, is used as medicine with the inner hard bone heart of Cornu Bovis seu Bubali.Nature and flavor are bitter, temperature.Merit can be stopped blooding.
Herba Caryopteridis Incanae, is Verenaceae Herba Caryopteridis Incanae platymiscium Herba Caryopteridis Incanae Caryopteris incana (Thunb.) Miq., is used as medicine with herb or root.Nature and flavor are pungent, temperature.Merit can dispelling wind to relieve the exterior syndrome, expelling phlegm for arresting cough, scattered silt pain relieving.
Composition principle: the etiology unknown of sudden hearing disability, a lot of paathogenic factor all may cause sudden hearing disability, and mainly contain viral infection theory, circulatory disturbance theory, theory of autoimmunity and the membranous labyrinth that obtain at present extensively accreditation are broken theory etc.In viral infection theory, the acute cochlitis that the cause of disease of sudden hearing disability may cause for virus or acute cochleovestibular labyrinthitis, at the Etiological that circulatory disturbance theory Middle inner ear blood supply disorder is sudden hearing disability, theory of autoimmunity is the pathogenesis that sudden hearing disability is newer.Traditional Chinese Medicine is thought, sudden hearing disability, also known as sudden deafness, mostly being few YANG excess heat, as pointed out " deafness all belongs to heat " in " danxi's experiential therapy is deaf ", and thinking that few sun is fainted cloudy ill and deaf, also be heat in blood, also have YIN-fire dynamic and deaf, evil fire-transformation and deafness etc., even if deuteropathic deafness also answers pathogenic fire reducing greatly.This kind of rule for the treatment of is consistent with viral theory, but numerous known, and sudden hearing disability pathogenic factor is various, and viral infection is only a kind of cause of disease, so, to relieve inflammation or internal heat as the Modified Minor Decoction of Bupleurum curative effect of the rule for the treatment of is not high.
Inventor's clinical research for many years finds, the generation of sudden hearing disability is relevant with meridians insubstantial phlegm, when expectorant agglutinate poly-to a certain extent time, endogenous fire disturbance and sick.Relieve inflammation or internal heat merely, though can deal with problems for the moment, but expectorant is solidifying not to be gone, and is easy to recurrence.And the expectorant of all meridians, the institute of lid and Tianjin blood, and solely attack its expectorant, then Tianjin blood is hindered again, and vigour more exhausts, and with going with change, expectorant must be more.Be that event we avoid using eliminating phlegm eliminating stagnation medicine, its reason is that meridians stagnation of phlegm is different from visible phlegm, inventor's clinical experience gained: use such medicine, and meridians conduction irritability, easily causes the untoward reaction such as chronic pain and acoustic nerve abnormal reflection.
Compared with prior art, the present invention has following characteristics.
1, ferrum rice and Fructus cinnamomi immaturus coordinate for monarch drug, and inventor studies discovery: ferrum rice is cold sliding, clearing away phlegm pathogenic fire reducing, the expectorant that network of passing through, flesh side, film are outer, use same with Fructus cinnamomi immaturus, make warm its warp solid of Fructus cinnamomi immaturus, and cold its network logical of ferrum rice, the two sweet cold taste brings out the best in each other, indispensable.Do not have the cooperation of Fructus cinnamomi immaturus Wen Hanggu warp, and solely attack its expectorant, then Tianjin blood is hindered again, and vigour more exhausts, and with going with change, expectorant must be more.In fire-clearing medicament, add the Fructus cinnamomi immaturus having Wen Tonggu through effect, be the maximum feature of this prescription.
2, Herba Moslae Chinensis dehumidifying is regulated the flow of vital energy, and Herba Dracocephali dredging collateral is subsided a swelling, and this two medicine is the medicine that the assistant of ferrum rice helps.
3, Fructus Lycii enriching yin and nourishing kidney, Radix Dipsaci nourishing the liver and kidney, Rhizoma Acori Graminei removing dampness is whetted the appetite, reinforcing Guyuan, eliminates the inherent cause of disease of sudden deafness from source.
4, the motionless blood of Spina Gleditsiae dredging collateral, and have poison holding effect, Herba Caryopteridis Incanae dissipating blood stasis for subsidence of swelling, this two medicines topical application can alleviate cochlea local microcirculation obstacle, excited acoustic nerve and ear cells, promotes the biological activity of internal ear neutral net, dredges the sering of inaccessible stasis blocking.
5, Turbo cornutus Solander, Flos Helianthi dispel the wind suppressing the hyperactive liver dampness removing, eliminate the external cause of disease of sudden deafness.
6, inventor's experimentation shows: low dose of Turbo cornutus Solander can increase local skin permeability effectively.
7, in one row falls apart dredging collateral medicine, add low dose of Os-Medulla Bovis seu Bubali, play assistant and make use, Kai Heyou road, reduce side effect.
8, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: 20 parts, ferrum rice, Fructus cinnamomi immaturus 10 parts, Herba Moslae Chinensis 6 parts, Herba Dracocephali 10 parts, Spina Gleditsiae 6 parts, Fructus Lycii 10 parts, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Os-Medulla Bovis seu Bubali 6 parts, Herba Caryopteridis Incanae 20 parts.
The preparation method of embodiment 1 is: ferrum rice, Fructus cinnamomi immaturus, Herba Moslae Chinensis, Herba Dracocephali, Spina Gleditsiae, Fructus Lycii, Radix Dipsaci, Rhizoma Acori Graminei, Flos Helianthi, Turbo cornutus Solander, Os-Medulla Bovis seu Bubali, Herba Caryopteridis Incanae mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate is merged into decoction.
Embodiment 2, crude drug weight proportion: 10 parts, ferrum rice, Fructus cinnamomi immaturus 6 parts, Herba Moslae Chinensis 3 parts, Herba Dracocephali 6 parts, Spina Gleditsiae 3 parts, Fructus Lycii 6 parts, Radix Dipsaci 6 parts, Rhizoma Acori Graminei 6 parts, Flos Helianthi 6 parts, Turbo cornutus Solander 1 part, Os-Medulla Bovis seu Bubali 3 parts, Herba Caryopteridis Incanae 10 parts.
Embodiment 3, crude drug weight proportion: 20 parts, ferrum rice, Fructus cinnamomi immaturus 10 parts, Herba Moslae Chinensis 6 parts, Herba Dracocephali 10 parts, Spina Gleditsiae 6 parts, Fructus Lycii 10 parts, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Os-Medulla Bovis seu Bubali 6 parts, Herba Caryopteridis Incanae 20 parts.
Embodiment 4, crude drug weight proportion: 30 parts, ferrum rice, Fructus cinnamomi immaturus 12 parts, Herba Moslae Chinensis 10 parts, Herba Dracocephali 12 parts, Spina Gleditsiae 10 parts, Fructus Lycii 12 parts, Radix Dipsaci 12 parts, Rhizoma Acori Graminei 12 parts, Flos Helianthi 12 parts, Turbo cornutus Solander 5 parts, Os-Medulla Bovis seu Bubali 10 parts, Herba Caryopteridis Incanae 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Radix Dipsaci, Fructus cinnamomi immaturus, Spina Gleditsiae coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Turbo cornutus Solander, Os-Medulla Bovis seu Bubali are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) ferrum rice, Herba Moslae Chinensis, Herba Dracocephali, Fructus Lycii, Flos Helianthi, Rhizoma Acori Graminei, Herba Caryopteridis Incanae are decocted with water 2 times, filter, merging filtrate, it is 1.20(50 DEG C that filtrate is concentrated into relative density), adding ethanol makes alcohol content be 60%, leaves standstill and makes precipitation, get supernatant, reclaim ethanol and be concentrated into relative density 1.25, obtaining thick paste;
(4) fine powder of the volatile oil of step 1 gained, step 2 gained is added the thick paste of step 3 gained, stir, dry, pulverize, cross 100 mesh sieves, to obtain final product.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
The efficient combination of said medicine, coordinates mutually, and effectively reach the object for the treatment of sudden hearing disability, the above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: choose sudden hearing disability patient 90 example of in January, 2012 ~ 2013 year December.Inclusion criteria: allly occur suddenly auditory dysesthesia or auditory dysesthesia companion tinnitus, the symptom such as dizzy, through clinical examination, pure tone electric audiometry, acoustic immitance, vestibular function and iconography (head and lnner stripe CT) check, get rid of central neuropathy, according to the standard that Chinese Medical Association's ENT & HN Surgery Dept. credit in 2005 can be formulated in Jinan, be diagnosed as sudden hearing disability person.Exclusion standard: 1. through extramural hospital treatment person, 2. auditory dysesthesia person, 3. age > 65 years old person, 4. disease time > 14d person in the past.
1.1.2 divide into groups: adopt simple randomized grouping to design, often organize each 30 examples.Three groups through statistical analysis, the difference of age, sex, the state of an illness does not have statistical significance (P>0.05), has comparability.
1.2 method.
1.2.1 administering mode: matched group: oral methylcobalamin tablet 0.5mg, 1 time/d.Ion-transmission group: adopt the embodiment of the present invention 1 gained decoction capable ion-transmission of nebula wind scoop after point gb 2 and ear before ear.Acupuncture point dresses group: dress the embodiment of the present invention 3 gained powder before ear after (side door, Tinggong, be a visitor at a meeting) and ear (nebula wind, Chi arteries and veins, Luxi) with mature vinegar.Ion-transmission group and acupuncture point dress treatment equal every day 2 times of group, three groups equal 14 days be 1 course for the treatment of.
1.2.2 curative effect determinate standard: recovery from illness: each frequency threshold of audibility of 0.25 ~ 4 kHz returns to normally, or reaches strong ear level, or reach this time ill front level.Effective: the average audition of said frequencies improves 30 more than dB.Effective: the average audition of said frequencies improves 15 ~ 30 dB.Invalid: the average hearing improved of said frequencies is less than 15 dB.
2 results.
After 1 course of therapy, three groups of curative effects see the following form:
| Number of cases | Recovery from illness | （%） | Effective | （%） | Effectively | （%） | Invalid | （%） | Total effective rate | |
| Matched group | 30 | 9 | 30.00% | 6 | 20.00% | 5 | 16.67% | 10 | 33.33% | 66.67% |
| Ion-transmission group | 30 | 17 | 56.67% | 6 | 20.00% | 4 | 13.33% | 3 | 10.00% | 90.00% |
| Acupuncture point dresses group | 30 | 16 | 53.33% | 7 | 23.33% | 3 | 10.00% | 4 | 13.33% | 86.67% |
Result shows: ion-transmission group and acupuncture point dress the cure rate of group and total effective rate higher than matched group (P<0.05).
3. conclusion.
The display of this result of study, applies ear acupuncture point ion-transmission of the present invention or powder dresses, and can effectively treat sudden hearing disability, cure rate and total effective rate are apparently higher than matched group (P<0.05).
Claims (2)
1. treat an external application Chinese medicine for sudden hearing disability, it is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts, ferrum rice, Fructus cinnamomi immaturus 6 ~ 12 parts, Herba Moslae Chinensis 3 ~ 10 parts, Herba Dracocephali 6 ~ 12 parts, Spina Gleditsiae 3 ~ 10 parts, Fructus Lycii 6 ~ 12 parts, Radix Dipsaci 6 ~ 12 parts, Rhizoma Acori Graminei 6 ~ 12 parts, Flos Helianthi 6 ~ 12 parts, Turbo cornutus Solander 1 ~ 5 part, Os-Medulla Bovis seu Bubali 3 ~ 10 parts, Herba Caryopteridis Incanae 10 ~ 25 parts.
2. a kind of external application Chinese medicine for the treatment of sudden hearing disability according to claim 1, is characterized in that being prepared from by the crude drug of following weight proportion: 20 parts, ferrum rice, Fructus cinnamomi immaturus 10 parts, Herba Moslae Chinensis 6 parts, Herba Dracocephali 10 parts, Spina Gleditsiae 6 parts, Fructus Lycii 10 parts, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 10 parts, Flos Helianthi 10 parts, Turbo cornutus Solander 2 parts, Os-Medulla Bovis seu Bubali 6 parts, Herba Caryopteridis Incanae 20 parts.
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| CN201310361372.2A CN103417771B (en) | 2013-08-19 | 2013-08-19 | External TCM drug for treatment of sudden hearing loss |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310361372.2A CN103417771B (en) | 2013-08-19 | 2013-08-19 | External TCM drug for treatment of sudden hearing loss |
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| CN201510115982.3A Division CN104666675A (en) | 2013-08-19 | 2013-08-19 | Penetration iron for treating sudden hearing loss |
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| CN103417771A CN103417771A (en) | 2013-12-04 |
| CN103417771B true CN103417771B (en) | 2015-03-11 |
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- 2013-08-19 CN CN201310361372.2A patent/CN103417771B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| Vafa Samarai,等.Sensory-neural hearing loss in pseudoexfoliation syndrome.《国际眼科杂志》.2012,第12卷(第8期),第1438-1441页. * |
| 乔秀艳,等.慢性中耳炎患者396耳发病年龄与听力丧失的相关性分析.《中国临床康复》.2005,第9卷(第22期),第30-31页. * |
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