CN117752637A

CN117752637A - Plaster and preparation method thereof

Info

Publication number: CN117752637A
Application number: CN202311794216.5A
Authority: CN
Inventors: 瞿治国
Original assignee: Hunan Weilingxian Traditional Chinese Medicine Technology Co ltd
Current assignee: Hunan Weilingxian Traditional Chinese Medicine Technology Co ltd
Priority date: 2023-12-25
Filing date: 2023-12-25
Publication date: 2024-03-26

Abstract

The invention relates to the technical field of traditional Chinese medicine plaster, and relates to a traditional Chinese medicine plaster for treating arthritis and hyperosteogeny, which comprises, by weight, 90-110 parts of rhododendron molle, 40-60 parts of alpine yarrow herb, 40-60 parts of raw radix aconiti kusnezoffii, 40-60 parts of raw arisaema tuber, 40-60 parts of raw pinellia tuber, 90-110 parts of gleditsia sinensis, 40-60 parts of honeycomb, 40-60 parts of paniculate swallowwort root, 10-30 parts of borneol, 40-60 parts of white mustard seed, 40-60 parts of yellow pod pepper and 40-60 parts of cassia twig. The plaster of the invention is safe and nontoxic, and is clinically applied to 2800 cases of patients, and has quick and lasting efficacy on cervical spondylosis, including cervical intervertebral disc herniation, cervical vertebra hyperosteogeny, neck and shoulder syndrome, scapulohumeral periarthritis, lumbar spondylosis, knee osteoarthritis, degeneration, rheumatism, rheumatoid arthritis, chronic injury and osteoarthritis.

Description

Plaster and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicine emplastrum, in particular to a traditional Chinese medicine emplastrum for treating arthritis and hyperosteogeny.

Background

The plaster is one of five Chinese medicinal pills, powder, paste, pill and soup, has long application history in China, belongs to external treatment, thereby avoiding the toxic and side effects of the oral medicament, has definite curative effect and is widely welcomed by the masses. The Xu Dachun of the Qing dynasty is: the plaster is especially powerful than the medicine taking, because the plaster is used for blocking qi and leading medicine property to enter the striae and striae from pores, and the medicine is effective in clearing and activating the channels and collaterals, or is effective in treating the disease caused by insufficient decoction, or is effective in dispelling the pathogenic wind. The medicine in the plaster is directly applied to the body surface acupoints, and the medicine property penetrates through the skin and skin striae to penetrate into subcutaneous tissues, so that the relative advantage of the medicine concentration is generated locally; on the other hand, the medicine can directly reach the disease sites of viscera and viscera with menstrual disorder through the through operation of the meridians and collaterals, and exert the 'meridian return' and functional effects of the medicine, thereby exerting the maximum pharmacological effect of the whole body.

The bone hyperplasia of neck, shoulder, waist and leg and joint pain are very wide in involvement range, various in variety and different in etiology, and common clinical symptoms can show pain. Aiming at the treatment process of neck, shoulder, waist, leg and back and all joint soreness, numbness and pain, the existing treatment scheme, such as 'Gutongling tincture', consists of the application of a cotton pad with water absorption and the addition of 'Gutongling tincture' liquid medicine: the main components are tarragon, dried ginger, dragon's blood, frankincense, myrrh and borneol, and the auxiliary materials are ethanol. But the treatment efficiency is low and the efficacy is not durable. And pain in multiple places or pain in the whole limb of a person often occurs, the applicability of the medicine is not strong, and all pain parts need to be fully covered.

Disclosure of Invention

The invention aims to provide a plaster with lasting efficacy and quick effect for treating arthritis and hyperosteogeny and a preparation method thereof.

The plaster comprises, by weight, 90-110 parts of rhododendron molle, 40-60 parts of alpine yarrow herb, 40-60 parts of raw radix aconiti kusnezoffii, 40-60 parts of raw arisaema, 40-60 parts of raw pinellia ternate, 90-110 parts of gleditsia sinensis lam, 40-60 parts of honeycomb, 40-60 parts of paniculate swallowwort root, 10-30 parts of borneol, 40-60 parts of white mustard seed, 40-60 parts of yellow pod pepper and 40-60 parts of cassia twig;

The patch comprises 5-15 parts of pill and 3-7 parts of fertilized protein; the pill is soaked semen Vaccariae.

The fertilized protein is obtained from hen raised in free range, and eggs laid by hen fertilization. When the eggs are looked after under the light, an annular ring with the size of about 8mm is arranged at the tail end of the eggs, namely the fertilized eggs, and the proteins are taken for standby.

Eggs, i.e. embryo egg cells, can gestate life after fertilization, and store the vital energy of the primordial yin and yang of kidney essence. Qi of kidney essence can lead to the whole process of growth and development of the main body. The kidneys in turn govern bone growth. The Chinese medicinal composition is used as a medicament for treating the pain of neck, shoulder, waist and leg, which is caused by the deficiency of liver and kidney, and has the effects of strengthening tendons and bones and tonifying liver and kidney.

Rhododendron molle, radix seu folium Lespedezae Cuneatae, and ramulus et folium Pittospori Glabrati are used as anesthetic and analgesic agent in medicine, and can be used for treating rheumarthritis and traumatic injury. Sex taste: pungent, bitter and warm, and is extremely toxic. It enters heart and liver meridians. The effective part in the plaster is root.

Radix Aconiti Brachypodi, herba Achilleae, radix Aconiti Kusnezoffii, radix Aconiti Szechenyiani, radix Achyranthis bidentatae, and radix Sanzhuan, with effects of diminishing inflammation, relieving pain, dispelling pathogenic wind, and removing dampness. Can be used for treating traumatic injury, rheumatalgia, and toothache; it is used externally to treat fracture, sprain, pyocutaneous disease and swelling. Sex flavor meridian tropism: bitter, pungent and warm in nature, and with strong toxicity. It enters heart, liver and spleen meridians.

The root tuber of the perennial herb Aconitum carmichaeli Debx of Ranunculaceae is mainly produced in Sichuan, and is picked up and cleaned in the summer, and the residue and fibrous root are removed and dried in the sun. Sex flavor meridian tropism: pungent, bitter and hot, with strong toxicity. It enters heart, liver and spleen meridians. Efficacy: warm meridians to stop pain, dispel wind and remove dampness.

Radix Aconiti Kusnezoffii, radix Aconiti Kusnezoffii Aconitum, rusnezoffii Reichb or radix Aconiti Kusnezoffii Aconitum chinense Paxt, which are wild plants of perennial herbs of Ranunculaceae. Processing method and nature and taste of the Chinese medicinal materials are similar to common monkshood mother root. It is often used in combination with the clinic for treating arthralgia due to wind-dampness, numbness and pain due to traumatic injury.

The spherical tubers of arisaema tuber Arisaema consanguinen msenott northeast arisaema tuber Arisaema amurense Maxin or arisaema tuber Arisaema hetero Phylum BL are produced in Henan, fujian, sichuan, etc. Collected in autumn and winter, removed stem and leaf, fibrous root and dried in the sun. Sex flavor meridian tropism: bitter, pungent and warm in nature, and toxic. It enters lung, liver and spleen meridians. Efficacy: dry dampness and resolve phlegm, dispel wind and stop spasm.

The underground tuber of Pinellia ternate, pinellia treata (Thanb) Breit, which is a perennial herb of Araceae, grows in all places of China, and is harvested and excavated in the autumn and the beard root is removed and dried in the sun, wherein the river basin of the Yangtze river is the largest. Sex flavor meridian tropism: pungent and warm, toxic and enters spleen, stomach and lung meridians. Efficacy: dry dampness and resolve phlegm, reduce adverse flow of qi and arrest vomiting, relieve distension and fullness and dissipate nodulation.

The fruit of Gleditsia sinensis Gledietisa sinensis Lam of Leguminosae is produced in northeast, north China, east China, south China, sichuan, guizhou and other places, is picked and ripe in autumn, dried in the sun, and sliced for use. Sex flavor meridian tropism: pungent and warm, with little toxicity. Enter lung and large intestine meridians. Efficacy: eliminating phlegm and inducing resuscitation.

Hives, wasp Vespa mandarinia smith and wasp Polistes mandarinus Sauss, are found in many places in China, and are more in the south. Taking nidus Vespae, sun drying or steaming, taking out dead pupa, and cutting the dead nidus Vespae into small pieces. Sex flavor meridian tropism: xin Ping it is toxic and enters liver and stomach meridians. Efficacy: attack toxin, expel wind and alleviate pain.

Cynanchum paniculatum, a perennial herb of Asclepiadaceae, cynanchum paniculatum Cynanchum paniculatum (Bunge) K.schum whole herb. Mainly produced in Jiangsu, zhejiang, shandong, hubei, hunan and other places, and is dug in summer and autumn to remove impurities, cut into sections and dried for production. Sex flavor meridian tropism: pungent and warm, it enters heart, liver and stomach meridians. Efficacy: pain relieving, wind dispelling, and toxic materials removing effects.

The trunk of borneol, borneol-family, evergreen arbor, borneol Dryobalanops aromatica Gaertn. F. Is distilled and cooled to obtain crystal, which is mainly used for synthesizing raw materials such as turpentine, camphor, etc. by chemical method. Or the sublimate of Blumea balsa mifera Dc leaves of blumea balsamifera (blumea balsamifera) which is a perennial herb of the Compositae is processed and split, and the method is called: "ai pian". The borneol incense is mainly produced in southeast Asia region, taiwan in China has the functions of introducing, blumea balsamifera, producing Guangdong, guangxi, yunnan and the like, and the finished product is stored in a cool place, sealed and can not pass fire when in use. Grinding into powder. The acupoint penetration liquid is "borneol fragrance". Sex flavor meridian tropism: is pungent and bitter and slightly cold. It enters heart, spleen and lung meridians. Efficacy: inducing resuscitation and refreshing mind, and clearing heat and relieving pain.

Semen Vaccariae: mature seeds of the annual or perennial herb vaccaria segetalis Vaccaria pyramidata Medic of the family caryophyllaceae are widely distributed throughout the country except for south China. When the seeds of the six July are ripe, the whole herb is cut and dried in the sun, the shell is naturally split, the seeds are collected, dried and stored. Sex flavor meridian tropism: pungent, sweet, flat and enter liver and stomach meridians. Efficacy: promoting blood circulation, dredging channels, promoting lactation, and promoting urination.

White mustard seed: seeds of the annual or biennial herb Brassica alba (L) Brassica juncea (L) Coss of cruciferae are produced in the places such as the Anhui and Henan and cultivated throughout the country. The fruits are picked up in summer and the seeds are taken and dried in the sun. Sex flavor meridian tropism: pungent and warm, enter lung meridian. Efficacy: warm lung, eliminate phlegm, promote qi circulation and dissipate nodulation.

Ramulus Cinnamomi: the shoots of Cinnamomum cassia Presl, a Lauraceae plant, are mainly produced in Guangxi, guangdong, yunnan and other places. The shoots are usually sun-dried in summer and cut into small sections. Sex flavor meridian tropism: pungent, sweet and warm. It enters heart, lung and bladder meridians. Efficacy: induce sweat to relieve exterior syndrome, warm meridians and activate yang.

Yellow pod pepper: the magnolia, solanaceae, annual or limited perennial herb is collected in summer and autumn and dried in the sun for later use, and is produced from Sichuan.

Efficacy: 1. the capsaicine-containing health care food has the effects of stimulating nerves, exciting cell activities, accelerating blood circulation and increasing local and whole body temperature, thereby achieving the effects of dispelling cold and warming channels. 2. The pain is relieved, the capsaicin can stimulate nerves, and the sensitivity of a human body to the pain can be reduced, so that the pain relieving effect is achieved. 3. Stomach invigorating and digestion promoting effects: the capsicum has the effects of stimulating oral cavity and intestines and stomach, increasing gastric peristalsis, strengthening spleen, promoting digestion, promoting gastric mucosa regeneration, preventing gastric ulcer, warming stomach, dispelling cold, and relieving vomiting and pain. 4. Yellow pod pepper produced by Sichuan has higher capsaicin content than common pepper, has higher aromatic smell and larger local stimulation, thus raising local and whole body temperature and having better effects of dispelling cold, warming channels, dredging collaterals and relieving pain.

The traditional Chinese medicine considers that cervical spondylosis comprises cervical intervertebral disc herniation and neck-shoulder syndrome; scapulohumeral periarthritis: including senile scapulohumeral periarthritis (fifty shoulder, frozen shoulder) injury type scapulohumeral periarthritis; lumbar vertebra disease: including lumbar vertebra hyperosteogeny, lumbar intervertebral disc protrusion, lumbar vertebra compression fracture, lumbar vertebra degeneration, rachitis, rheumatoid arthritis, ankylosing spondylitis and the like. Osteoarthritis of the knee joint, degenerative arthritis. Rheumatic and rheumatoid arthritis, chronic injury (including meniscus injury), osteoarthritis, etc. Most of the diseases are deficiency of vital qi, feeling of wind-cold-dampness evil, and stagnation of phlegm-dampness in muscles, tendons, bones and joints of human body due to qi deficiency and qi stagnation, so that normal operation of qi, blood and body fluids of human body is blocked, and pain of affected parts is caused, cold paralysis, numbness and movement disorder are serious, and serious people can suffer from difficult self-care, pain and tolerance, and work and life of patients are seriously affected. The key pathology is: a series of symptoms such as pain, coldness, numbness, difficulty in flexion and extension and limited movement are caused by deficiency of qi and blood or invasion of pathogenic wind, phlegm-dampness obstructing the meridians and phlegm-blood stasis between muscles, tendons and bones and joints.

Among the medicinal components, rhododendron molle, radix aconiti kusnezoffii, cassia twig and red pepper have the effects of warming interior cold, warming and activating blood stasis, warming and activating meridians and relieving pain. Rhizoma arisaematis, rhizoma Pinelliae and semen Sinapis Albae are effective in eliminating dampness and phlegm, warming and resolving cold phlegm, and eliminating phlegm and dampness outside the skin and lining, so as to remove phlegm and dampness in vivo, relieve blockage of joint tendons and bones, and enable limb joints such as heavy attachment, paralysis and inactivity to move freely. Honeycomb and paniculate swallowwort root have the functions of dispelling wind and supporting yang, promoting the movement of joints, dispelling wind and relieving pain, dispelling wind and relieving itching, so that the joint movement of limbs of patients is increased. The traditional Chinese medicine considers that the wind is the long pathogenic wind of hundred diseases, and the disease is not easy to relapse. And the paniculate swallowwort root has the function of detoxification, most of the medicines in the recipe have certain toxicity, and the paniculate swallowwort root can increase the effects of dispelling wind, relieving pain and dispelling wind and relieving itching on one hand and can solve the toxicity of other medicines on the other hand, thus bringing out the best in each other.

Most of the medicines in the recipe are warm, and the property of the borneol is cold and cool, so that other medicines can be prevented from being excessively warm and the bias of the medicines can be inhibited. The borneol has aromatic flavor, has the function of inducing resuscitation, can permeate into gaps of muscles, tendons and bones, can achieve the purpose of removing malignant diseases (cold, dampness, wind, phlegm and blood stasis), and has the effect of relieving pain, and the combination of the medicines can relax tendons and remove collaterals, warm yang and remove cold, warm meridians and activate blood to remove blood stasis, and activate joints to enable the joints to recover quickly.

In the formula, rhododendron molle, radix aconiti kusnezoffii and radix aconiti kusnezoffii have the effects of warming the inner part and dispelling cold, warming and activating blood stasis, warming and activating meridians and warming yang and relieving pain, and aiming at the pathogenesis reasons and mechanisms of neck, shoulder, waist and leg pain, the four medicaments are mainly cold stagnation channels, cold evil and yang injury, cold coagulation stasis, and cause the qi, blood and body fluid of a human body to be blocked, blockage and pain caused by obstruction, so that the four medicaments cooperate with each other and can take a main effect as principal medicaments aiming at the main pathogenesis. The second main cause of pain in the neck, shoulders, waist and legs is phlegm-dampness, which is a disease, and can stagnate muscles, tendons and bones, joints and orifices, resulting in obstruction of qi, blood and body fluids, stagnation of blood and pain. In the recipe, arisaema tuber, pinellia tuber, gleditsia sinensis lam and white mustard seed can warm and resolve phlegm and dampness, expel phlegm and dampness outside muscle, tendons, joints, orifices and skin, and are helpful for monarch drug, warm and dispel pathogenic cold and dampness, and achieve the purposes of warming meridians and relieving pain, dispelling pain and getting tired. The third main cause of pain in the neck, shoulders, waist and legs is pathogenic wind. Wind is often accompanied by cold and dampness, and flows into muscles, tendons, joints, orifices and the like to obstruct qi, blood and body fluids, obstruction of arthralgia, pain, and the like, and the Chinese medicinal herbs of the formula, paniculate swallowwort root and cassia twig can dispel wind and remove pathogenic factors, dispel wind and dredge collaterals, dispel wind and relieve pain, and mainly solve the problem of the free pain of affected parts, and are used as ministerial drugs together with rhizoma arisaematis, pinellia ternate, gleditsia sinensis and white mustard seed. The principal and ministerial drugs together can treat the main causes of the neck, shoulder, waist and leg pains, and can achieve the effects of removing the causes of the production, so that the pathogenic factors (cold evil, damp evil and wind evil) can not stay in the body to radically treat the pains. In the recipe, borneol, cassia twig and chilli are used as adjuvant drugs, which can be used for inducing resuscitation with fragrance, warming limb pores and bone orifices, enabling monarch and minister drugs to permeate to affected parts rapidly, and expelling cold, dampness and pathogenic wind. Semen Vaccariae has effects of promoting blood circulation, dredging collaterals, and smoothing Li Kaiqiao, and guiding monarch, minister and adjuvant to specific acupoints. Thus, the effects of warming interior cold, warming channels, dredging collaterals, warming and activating blood stasis, warming yang, relieving pain, expelling cold, dampness and pathogenic wind in the body can be achieved, so that the body can not stay between muscles, tendons and bones, joints and orifices, and the body qi, blood and body fluid can restore normal operation, and the purposes of eliminating pathogenic factors and recovering the body are achieved.

The invention also claims a preparation method of the plaster, which comprises the following steps: coating 5-20mL of the medicine components on a plaster carrier, and then packaging; the preparation method of the medicine component of the large emplastrum comprises the following steps:

s1, mixing rhododendron molle, radix aconiti kusnezoffii, rhizoma arisaematis, rhizoma pinelliae, gleditsia sinensis lam, honeycomb and paniculate swallowwort root in proportion, crushing, soaking in ethanol for 10-30d, adding borneol, continuously soaking for 2-9d, and taking out the soaking liquid to obtain a component 1;

s2, mixing semen brassicae, yellow pod pepper and cassia twig in proportion, crushing, soaking in ethanol for 10-30d, and taking out the soaking solution to obtain a component 2;

mixing the component 1 and the component 2 according to the volume ratio of 90-99:1-10 to obtain the medicine component.

In one preferred embodiment, in the step S1, the medicine liquid is soaked in ethanol for 13-17d until the medicine liquid is in a reddish brown color and has a strong and pungent smell.

Too long soaking time is unfavorable for the exertion of the drug effect. Too short effective components are not completely extracted, too long extracted impurities are too many, and the drug effect is obviously affected.

In one preferred embodiment, the ethanol is 70-80% ethanol.

In one preferred embodiment, the borneol is added in the step S1, and the soaking is continued for 3-7d until the liquid medicine is reddish brown and has strong borneol smell.

Similarly, too long soaking time is unfavorable for the exertion of the drug effect. The effective components which are too short are not completely extracted, and the excessive impurities in the borneol which is too short are too much extracted, so that the drug effect is obviously affected.

In one preferred embodiment, the soaking time in the step S2 is 15-25d until the liquid medicine is orange.

In one preferred embodiment, the method of preparing the pill comprises: mixing semen Sinapis Albae, yellow Capsici fructus, and ramulus Cinnamomi at a certain proportion, pulverizing, soaking in ethanol for 10-30d, adding semen Vaccariae, soaking for 3-7d, and taking out semen Vaccariae to obtain pill.

In one preferred embodiment, the mass ratio of the white mustard seed, the yellow pod pepper and the cassia twig is as follows: 40-60 parts of white mustard seed, 40-60 parts of yellow pod pepper and 40-60 parts of cassia twig

In one preferred embodiment, the method of preparing the patch comprises the steps of:

dipping fertilized protein, uniformly coating on plaster matrix, dipping 3-5 pills with shrub branches, and fixing on fertilized protein to obtain the small plaster.

The fertilized protein has better viscosity and can fix the pill.

The method for obtaining the small branches of shrubs is to take the small branches (cut off like the length of a cotton swab) of the shrubs facing the east, and the physiological properties of the liver are liver blood and liver main tendons according to the traditional Chinese medicine viewpoint. The use of Oriental wood has the effects of biochemical treatment, qi and blood circulation, and moistening tendons and vessels.

The invention also claims a using method of the plaster, which comprises the following steps: the small plaster is applied to the acupoints along the meridian and collateral circulation path, and the large plaster is applied to the main pain part.

The size of the large plaster is 15-25cm long and 5-15cm wide.

The size of the small plaster is 0.5-2cm long and 0.5-2cm wide.

For example, when a patient suffers from pain or hyperplasia due to cervical spondylosis, such as rheumatoid arthritis, a small patch is applied to a small acupoint where pain is caused, and only a small patch is applied to an acupoint where a major pain is caused, such as a painted joint, and a large patch is applied to other pain. The two components complement each other, promote treatment, solve the problem of pain at multiple parts of the whole body at the same time, and avoid the problem of pasting large plaster on the whole body at the same time.

The beneficial effects of the invention are as follows: the plaster of the invention is safe and nontoxic through toxicity test, and has no adverse reaction to human body after clinical use for a plurality of treatment courses. And is clinically applied to 2800 patients, has quick and lasting effects on cervical spondylosis, cervical spondylosis including cervical disc herniation, cervical vertebra hyperosteogeny, cervical shoulder syndrome, scapulohumeral periarthritis (including senile scapulohumeral periarthritis, (fifty shoulder and frozen shoulder) acute and chronic injury type scapulohumeral periarthritis), lumbar spondylosis (including lumbar vertebra hyperosteogeny, lumbar disc herniation, lumbar vertebra compression fracture, lumbar vertebra degenerative disease, spondylitis, rheumatoid arthritis, ankylosing spondylitis and the like), knee osteoarthritis, degeneration, rheumatism, rheumatoid arthritis, chronic injury (including meniscus injury) and osteoarthritis. The plaster disclosed by the invention has the effects of strengthening yang and tonifying qi, warming and dredging channels and collaterals, warming yang and dispelling cold, dispelling phlegm and dampness, dispelling wind and relieving pain, and smoothing joints, and has the curative effect of 90% on clinical lumbar vertebra diseases, and can be suitable for young people under 40 years old and old people over 75 years old. The plaster of the invention has quick effect, and most patients can be effectively treated after being covered for 10 days in one treatment course. For patients with pains of several decades, the pain is obviously relieved after one treatment course, and the treatment effect is obvious after ten treatment courses at maximum. The plaster has low cost, wide application and outstanding curative effect, and accords with the principles of simplicity, convenience, low cost and inspection.

Drawings

FIG. 1 is a cervical spondylosis patch;

FIG. 2 is a cervical spondylosis plaster;

fig. 3 is a shoulder Zhou Yanxiao patch;

fig. 4 is a large plaster for scapulohumeral periarthritis;

FIG. 5 is a lumbar vertebrae disease patch;

FIG. 6 is a lumbar vertebra disease plaster;

fig. 7 is a patch for knee arthritis;

fig. 8 is a patch for knee arthritis.

Detailed Description

Example 1

A large plaster 1 comprises plaster carrier and medicinal components, wherein the medicinal components comprise spike liquid and chilli liquid.

Penetration liquid 1 is composed of: 100 g of rhododendron molle, 50 g of radix aconiti carmichaeli, 50 g of radix aconiti kusnezoffii, 50 g of rhizoma arisaematis, 50 g of rhizoma pinelliae, 100 g of gleditsia sinensis lam, 50 g of honeycomb, 50 g of paniculate swallowwort root and 20 g of borneol.

The preparation method of the penetration liquid 1 comprises the following steps:

1. 100 g of rhododendron molle, 50 g of radix aconiti agrestis, 50 g of radix aconiti kusnezoffii, 50 g of rhizoma arisaematis, 50 g of rhizoma pinelliae, 100 g of gleditsia sinensis lam, 50 g of honeycomb and 50 g of paniculate swallowwort. Selecting raw materials: mainly removes the mildew and insect bite, pulverizes into coarse particles, puts the non-woven bag into reserve.

2. The method comprises the steps of using 30 jin of volumetric glass wine bottles, carrying out rubber sealing rings on the upper cover, carrying out stainless steel faucet on the lower cover, using 75% ethanol to carry out 20 jin, placing nine crushed coarse particles such as rhododendron molle and the like into the wine bottles, tightly covering the upper cover to prevent ventilation, soaking for 15 days, enabling the liquid medicine to be in a reddish brown color, enabling the liquid medicine to be in a strong smell, placing 20 g of crushed borneol into the wine bottles to be soaked for five days, enabling the liquid medicine to be in a reddish brown color after the whole liquid medicine is 20 days, enabling the liquid medicine to be in a strong smell, and bottling the liquid medicine for later use to prepare a penetration liquid finished product.

The chilli liquid 1 comprises the following components: 50 g of white mustard seed, 50 g of yellow pod pepper produced by Sichuan and 50 g of cassia twig.

The preparation method of the chilli liquid 1 comprises the following steps: a glass wine bottle with the volume of 10 jin is used, a rubber sealing ring is arranged on an upper cover, a stainless steel tap is arranged on a lower cover, 50 g of semen brassicae (mildewed and insect bitten part) which is carefully selected, 50 g of yellow pod peppers produced by Sichuan and 50 g of cassia twig are crushed into coarse particles, the coarse particles are bagged by non-woven fabrics, 10 jin of 75% ethanol is added into the glass wine bottle, the glass wine bottle is tightly covered by the upper cover, no air leakage is caused, a shady place is placed for 20 days, the liquid medicine is orange and transparent for 20 days, and the liquid medicine can be bottled for later use to prepare a pepper liquid finished product.

Mixing the penetrating fluid 95 ml with the chili liquid 5 ml, and coating the mixed liquid 10 ml on the plaster carrier to obtain the plaster 1.

A patch 1 comprises pill 2g and fertilized protein 1g; the pill is soaked semen Vaccariae.

The preparation method of the patch 1 comprises the following steps:

The preparation method of the pill of the patch comprises the following steps: 500 g of selected (mildew-removing and insect-biting-removing) semen vaccariae is soaked in a glass wine bottle with the volume of 10 jin, 10 jin of 75% ethanol is added, 50 g of selected (mildew-removing and insect-biting-removing) semen brassicae is added, 50 g of Sichuan yellow pod pepper and 50 g of cassia twig are produced, the raw materials are crushed into coarse particles, the coarse particles are placed in the glass bottle by a non-woven fabric bag for 20 days, the semen vaccariae is soaked for 5 days, and then the semen vaccariae is taken out, and 10 g of the semen vaccariae is packaged each time to obtain the pill.

The branches of the field shrubs (cut off like the length of a cotton swab) facing the east are taken, and the east is the liver with the physiological properties of liver blood and liver tendons from the viewpoint of traditional Chinese medicine. The use of Oriental wood has the effects of biochemical treatment, qi and blood circulation, and moistening tendons and vessels.

Example 2

A large plaster 2 comprises plaster carrier and medicinal components, wherein the medicinal components comprise spike liquid and pepper liquid.

Penetration liquid 2: 50 g of radix aconiti, 50 g of radix aconiti kusnezoffii, 50 g of rhizoma arisaematis, 50 g of rhizoma pinelliae, 100 g of gleditsia sinensis, 50 g of honeycomb, 50 g of paniculate swallowwort root and 20 g of borneol.

Otherwise, the same as in example 1 was conducted.

Example 3

A large plaster 3 comprises plaster carrier and medicinal components, wherein the medicinal components comprise spike liquid and pepper liquid.

Penetration liquid 3 is composed of: 100 g of rhododendron molle, 50 g of raw radix aconiti kusnezoffii, 50 g of raw arisaema tuber, 50 g of raw pinellia tuber, 100 g of gleditsia sinensis lam, 50 g of honeycomb, 50 g of paniculate swallowwort root and 20 g of borneol.

Otherwise, the same as in example 1 was conducted.

Example 4

A large plaster 4 comprises plaster carrier and medicinal components, wherein the medicinal components comprise spike liquid and pepper liquid.

Penetration liquid 4: 50 g of raw radix aconiti, 50 g of raw radix aconiti kusnezoffii, 50 g of raw arisaema tuber, 50 g of raw pinellia tuber, 100 g of gleditsia sinensis lam, 50 g of honeycomb, 50 g of paniculate swallowwort root and 20 g of borneol.

Otherwise, the same as in example 1 was conducted.

Example 5

A large plaster 5 comprises plaster carrier and medicinal components, wherein the medicinal components comprise spike liquid and chilli liquid.

Penetration liquid 5 is composed of: 100 g of rhododendron molle, 50 g of radix aconiti carmichaeli, 50 g of radix aconiti kusnezoffii, 50 g of rhizoma arisaematis, 50 g of rhizoma pinelliae, 100 g of gleditsia sinensis lam and 50 g of honeycomb.

Otherwise, the same as in example 1 was conducted.

Example 6

A large plaster 6 comprises plaster carrier and medicinal components, wherein the medicinal components comprise spike liquid and chilli liquid.

Penetration liquid 6 is composed of: 120 g of rhododendron molle, 40 g of alpine yarrow herb, 40 g of raw radix aconiti, 50 g of raw radix aconiti kusnezoffii, 50 g of raw arisaema tuber, 50 g of raw pinellia tuber, 100 g of gleditsia sinensis lam, 50 g of honeycomb, 50 g of paniculate swallowwort root and 20 g of borneol.

Otherwise, the same as in example 1 was conducted.

Example 7

A large plaster 7 comprises plaster carrier and medicinal components, wherein the medicinal components comprise spike liquid and pepper liquid.

Penetration liquid 7: 70 g of rhododendron molle, 70 g of radix aconiti carmichaeli, 50 g of radix aconiti kusnezoffii, 50 g of rhizoma arisaematis, 50 g of rhizoma pinelliae, 100 g of gleditsia sinensis lam, 50 g of honeycomb, 50 g of paniculate swallowwort root and 30 g of borneol.

Otherwise, the same as in example 1 was conducted.

Example 8

A large plaster 8 comprises plaster carrier and medicinal components, wherein the medicinal components comprise spike liquid and chilli liquid.

Penetration liquid 8 is composed of: 100 g of rhododendron molle, 50 g of radix aconiti carmichaeli, 50 g of radix aconiti kusnezoffii, 50 g of rhizoma arisaematis, 50 g of rhizoma pinelliae, 100 g of gleditsia sinensis lam, 50 g of honeycomb, 50 g of paniculate swallowwort root and 20 g of borneol.

The preparation method of the penetration liquid 8 comprises the following steps:

2. The method comprises the steps of placing nine crushed coarse particles such as rhododendron molle in a wine bottle with a 30 jin volume glass wine bottle, a rubber sealing ring on an upper cover, a stainless steel faucet on a lower cover, placing the crushed coarse particles such as rhododendron molle in the wine bottle with 75% ethanol, tightly covering the upper cover to prevent ventilation, soaking for 5 days, enabling the liquid medicine to be light red, enabling the crushed borneol to be strong, placing 20 g of crushed borneol in the wine bottle, soaking for five days, enabling the liquid medicine to be light red after the whole liquid medicine is 10 days, enabling the liquid medicine to be strong, and bottling the liquid medicine for later use to prepare a penetration liquid finished product.

Otherwise, the same as in example 1 was conducted.

Example 9

A large plaster 9 comprises plaster carrier and medicinal components, wherein the medicinal components comprise spike liquid and pepper liquid.

Penetration liquid 9 is composed of: 100 g of rhododendron molle, 50 g of radix aconiti carmichaeli, 50 g of radix aconiti kusnezoffii, 50 g of rhizoma arisaematis, 50 g of rhizoma pinelliae, 100 g of gleditsia sinensis lam, 50 g of honeycomb, 50 g of paniculate swallowwort root and 20 g of borneol.

The preparation method of the penetration liquid 9 comprises the following steps:

2. The method comprises the steps of using a 30 jin volume glass wine bottle, a rubber sealing ring on an upper cover, a stainless steel faucet on a lower cover, using 75% ethanol to 20 jin, placing nine crushed coarse particles such as rhododendron molle into the wine bottle, tightly covering the upper cover to prevent ventilation, soaking for 30 days, enabling the liquid medicine to be in a reddish brown color, enabling the liquid medicine to be very sharp and strong, placing 20 g of crushed borneol into the wine bottle, soaking for five days, enabling the liquid medicine to be in a reddish brown color after the whole liquid medicine is 35 days, enabling the liquid medicine to be in a strong liquid medicine, bottling the liquid medicine for later use, and preparing a penetration liquid finished product.

Otherwise, the same as in example 1 was conducted.

Example 10

A large plaster 10 comprises a plaster carrier and a medicinal component, wherein the medicinal component comprises a spike liquid and a chilli liquid.

Penetration liquid 10 is composed of: 100 g of rhododendron molle, 50 g of radix aconiti carmichaeli, 50 g of radix aconiti kusnezoffii, 50 g of rhizoma arisaematis, 50 g of rhizoma pinelliae, 100 g of gleditsia sinensis lam, 50 g of honeycomb, 50 g of paniculate swallowwort root and 20 g of borneol.

The preparation method of the penetration liquid 10 comprises the following steps:

2. The method comprises the steps of using 30 jin of volumetric glass wine bottles, carrying out rubber sealing rings on the upper cover, carrying out stainless steel faucet on the lower cover, using 50% ethanol to carry out 20 jin, placing nine crushed coarse particles such as rhododendron molle and the like into the wine bottles, tightly covering the upper cover to prevent ventilation, soaking for 15 days, enabling the liquid medicine to be in a reddish brown color, enabling the liquid medicine to be in a strong smell, placing 20 g of crushed borneol into the wine bottles to be soaked for five days, enabling the liquid medicine to be in a reddish brown color after the whole liquid medicine is 20 days, enabling the liquid medicine to be in a strong smell, and bottling the liquid medicine for later use to prepare a penetration liquid finished product.

Otherwise, the same as in example 1 was conducted.

Example 11

A large plaster 11 comprises plaster carrier and medicinal components, wherein the medicinal components comprise spike liquid and pepper liquid.

Penetration liquid 11 is composed of: 100 g of rhododendron molle, 50 g of radix aconiti carmichaeli, 50 g of radix aconiti kusnezoffii, 50 g of rhizoma arisaematis, 50 g of rhizoma pinelliae, 100 g of gleditsia sinensis lam, 50 g of honeycomb, 50 g of paniculate swallowwort root and 20 g of borneol.

The preparation method of the penetration liquid 11 comprises the following steps:

The chilli liquid 11 comprises the following components: 50 g of white mustard seed and 50 g of cassia twig.

The preparation method of the chilli liquid 11 comprises the following steps: the method comprises the steps of using a glass wine bottle with a volume of 10 jin, a rubber sealing ring is arranged on an upper cover, a stainless steel faucet is arranged on a lower cover, 50 g of semen brassicae is selected (mildewed and insect bitten parts), 50 g of cassia twig is crushed into coarse particles, the coarse particles are packaged by non-woven fabrics, 10 jin of 75% ethanol is added into the glass wine bottle, the glass wine bottle is tightly covered by the upper cover, no air leakage is caused, the glass wine bottle is placed at a cool place for 20 days, the liquid medicine is orange and transparent for 20 days, and the liquid medicine can be bottled for standby, so that a pepper liquid finished product is prepared.

Mixing the penetration liquid 95 ml with the chili liquid 5 ml, and coating the mixed liquid 10 ml on the plaster carrier to obtain the large plaster 11.

Example 12

The chilli liquid 12 comprises the following components: 50 g of white mustard seed, 50 g of yellow pod pepper produced by Sichuan and 50 g of cassia twig.

The preparation method of the chilli liquid 12 comprises the following steps: the glass wine bottle with 10 jin of volume is used, the upper cover is provided with a rubber sealing ring, the lower part is provided with a stainless steel tap, the selected raw materials (mildew and insect bite removing part) are crushed into coarse particles, the coarse particles are packaged by non-woven fabrics, 10 jin of 75% ethanol is added into the glass wine bottle, the glass wine bottle is tightly covered by the upper cover, no air leakage exists, the glass wine bottle is placed in a cool place for 10 days, the liquid medicine is orange and transparent, and the liquid medicine can be bottled for standby, so that a chilli liquid finished product is prepared.

Otherwise, the same as in example 1 was conducted.

Example 13

A large plaster 13 comprises plaster carrier and medicinal components, wherein the medicinal components comprise spike liquid 1 and chili liquid 1.

Mixing the penetration liquid 80 ml with the chili liquid 20 ml, and coating the mixed liquid 10 ml on the plaster carrier to obtain the large plaster 13.

Example 14

A large plaster 14 comprises a plaster carrier and a medicinal component, wherein the medicinal component consists of a spike liquid 1.

10 milliliters of the penetration liquid is coated on the plaster carrier to obtain the large plaster 14.

Example 15

Rodent model MSU-induced knee inflammation in male Wistar rats was treated, model mice were purchased from mslek lagrangian laboratory limited. Rats were divided into 15 groups of 5 rats each, with the average body weights of each group being similar. One group was model mice given normal diet with blank patches. The remaining groups were given the large patch treatments of examples 1-14, respectively, in addition to the normal diet. Day-1. A baseline reading is taken. The baseline knee diameter was measured by digital calipers. Baseline responses to mechanical allodynia as measured by von Frey fibers were recorded.

Rats were weighed on day 0 and plastered. Mechanical allodynia and knee diameter were measured and recorded 8 hours after application of the plaster, and weight, mechanical allodynia and knee diameter were measured and recorded daily for 7 days of continuous application.

The results show that: the knee diameter of the model mice increased significantly from 12.2mm on day 0 to 17.8mm on day 4, with a slight detumescence on day 7, which was 15.7mm. The response to mechanical allodynia decreased from 13.0g pressure on day 0 to 4.9g on day 4 and 6.1g on day 7, indicating an increase in pain response.

In the patch-treated experimental mice of example 1, the knee diameter was initially increased, but the knee diameter was restored to 12.2mm on day 5, and the response to mechanical allodynia was also restored to normal on day 5, indicating that arthritis in the model mice was effectively cured.

The patch-treated groups of experimental mice of examples 2-14 showed a significant 30-71% reduction in knee edema and 32-84% reduction in pain response compared to the model group mice, but all had significantly poorer efficacy than example 1.

The patch-treated experimental mice of example 13 developed mania after the patch application.

If only large iron paste is used, the medicine can also cure the disease, but the medicine has slower effect and longer time.

Example 16

Toxicity test

The puncture liquid of example 1 was applied to a normal mouse at a dose of 10 ml/kg each time for 4 times every 6 hours, and the spirit, activity, food intake, stool and urine of the mice were observed for 10 days continuously, without any abnormality with the normal mice before and without administration. A small amount of chilli liquid, namely 9.8 ml and 0.2 ml, is added, and the dose of the chilli liquid is 10 ml/kg each time when the chilli liquid is smeared on a white mouse body by the same method, and the chilli liquid is administrated for 4 times every 6 hours, and is continuously observed for 10 days. When the spirit of the white rat is observed, the spirit is more inspired, the activity is greatly increased, the food intake is also increased, and the stool and urine are also increased. The tolerance of the dosage of the mice reaches more than 200 to 300 times of the dosage of adults according to the weight kilogram, which proves that the plaster of the invention is safe to human bodies and can improve the excitability of organisms, thus showing that the disease resistance is enhanced.

Example 17

Clinical cases

Case (one) plum xx, women 65 years old. Hunan Yueyang City. For more than 10 years, 2021, 10 months and 9 days after suffering from cervical spondylosis, find me for diagnosis and treatment. It is manifested by cervical pain, frequent headache, and numbness of the upper limbs. The small acupoints of cervical vertebrae are covered with the small patch of example 1, while the large patch is covered behind the cervical vertebrae. Two courses of treatment, namely 'acupoint powerful penetration and thorn method', are carried out, and all symptoms disappear. Follow-up telephone call, no recurrence has occurred so far.

Case (II) patient wears XX, male 59 years old, hunan Changsha city person. The patient can find out the diagnosis in 3 or 15 days of 2023, suffers from lumbar disc herniation, and has symptoms of lumbago, right leg pain, difficult walking, one turn of walking, incapacity of working and difficult self-care of life. The other method is used for treating the lumbar vertebra for one month, the treatment cost is nearly ten thousand yuan, no curative effect is seen, the lumbar vertebra is increasingly heavy, the small plaster of the embodiment 1 is used for covering small acupoints of the lumbar vertebra, and the large plaster is used for covering the lumbago. Two treatment courses are treated, and the patients are thoroughly cured.

Case (III) Tang XX, female, 33 years old. Hunan Changsha city. For a diagnosis in 5 months 2023, the patient suffers from lumbar disc herniation and is combined with endplate inflammation. The treatment in each major hospital of Changsha has no curative effect for two months, and a certain trimethyl hospital recommends operation treatment, and does not agree. The confidence is lost during treatment, and the treatment effect is not hoped. The plaster of example 1 was used to treat the lumbago in the fourth day by the "acupoint powerful penetration method", and was stretched freely by various bending and leg-pressing actions. The treatment course is not complete.

In case (IV), wu XX, a man, 48 years old, 2023, 4 months and 27 days old is diagnosed, CT in a trimethyl hospital is diagnosed as lumbar three, lumbar four, lumbar five, sacral, lumbar disc herniation, the waist is bent and the hip is tilted when walking, walking is difficult, pain is hard, after the plaster of example 1 is used for a course of treatment by acupoint strong penetration, after the plaster is used for the third time, shenzhen is removed, the Shenzhen is needed to return to the long sand for 5 months and 6 times, the lumbago is stopped, and the plaster can be used for bending over to stretch legs to perform various activities such as normal people if walking.

Case (five) Wu XX, female, 75 years old. Hunan Changsha. The patient is diagnosed in 9 th year of 2021 and 7 th day, the knee joint is painful, the pain is connected with the left hip, the activity is limited, and the patient is hard to erect in one turn after walking. In a certain three-dimensional hospital, the artificial joint is required to be replaced, the patient refuses the operation, and then the patient is treated by the conservative therapy in each large and small hospital, which consumes five tens of thousands of times, and does not receive any curative effect. The plaster of the embodiment 1 has obvious curative effect after one treatment course of 'acupoint powerful penetration method'. But has not yet been fully restored, and therefore is treated with the following therapy for three courses of treatment (30 d), now restoring normal life.

Case (six) Huxx, 51 years old female, hunan Changsha. The patient is diagnosed in 5-8 days 2021, the shoulder pain on the right side is limited in activity, the patient cannot sleep to the right side at night, the pain is difficult to endure, and the plaster of the embodiment 1 is used for treating two courses of treatment by the acupoint powerful penetration method, so that the pain is completely eliminated and the activity is free.

Example 18

Clinical cases of Hunan Guisheng and Chinese medicine science and technology limited company Chinese medical clinic 2022.11.15-2022.12.21

1. 80 cases were treated. And observing the curative effect of the patients with shoulder, neck, waist and leg pain.

The method is divided into two groups according to a random number table method: group 40 was observed and group 40 was compared. The two groups of age, sex, illness, etc. are comparable.

2. Diagnostic criteria: is diagnosed according to 2012 Chinese medical science diagnostic curative effect standard of Chinese medical science.

3. Inclusion criteria: meets 2012 diagnostic curative effect standard of Chinese medical condition of national Chinese medicine

The diagnosed person: consciousness and consciousness, and can clearly and accurately express own opinion. Patients aged above 20 years and below 75 years. And the patients not receiving the similar medicines and the treatment methods before the test. Informed and consent was given to the study-related matters. There are cases where there is a marked concomitant syndrome or combined syndrome. The participants all have CT diagnosis basis.

4. All that is not in compliance with the inclusion standard:

treatment was not or could not be received on demand. The curative effect and the safety can not be judged, and the curative effect and the safety can not be judged due to incomplete data.

5. Intervention measures:

observation group: the plaster of example 1 was used for the main pain parts, and the small plaster was used for the remaining small acupoints. The preparation method of the patch is the same as that of the patch. Treating 10 cases of cervical spondylosis (including cervical vertebra hyperosteogeny, cervical vertebra joint degeneration and cervical intervertebral disc protrusion) respectively; 10 cases of scapulohumeral periarthritis (rotator cuff tear separated by MRI diagnosis); 10 lumbar vertebra diseases (including lumbar disc herniation, bulging, lumbar joint degeneration and lumbar vertebra hyperosteogeny); knee arthritis (knee degeneration, meniscus injury) 10 cases; experimental treatment was performed and the efficacy was recorded. Wherein, the small plaster for cervical spondylosis is shown in figure 1, and the large plaster is shown in figure 2; shoulder Zhou Yanxiao patch is shown in fig. 3, and large patch is shown in fig. 4; the small plaster for lumbar vertebra disease is shown in figure 5, and the large plaster is shown in figure 6; the small patch for knee arthritis is shown in fig. 7, and the large patch is shown in fig. 8.

(1) 6 acupoint patches (each containing penetration pill 2 particles) for cervical spondylosis (including cervical vertebra hyperosteogeny, cervical vertebra joint degeneration and cervical intervertebral disc protrusion) are respectively arranged at the side of a large vertebra by 0.5 inch, the side of a fifth cervical vertebra and a fourth cervical vertebra by 0.5 inch, a small acupoint patch is arranged at the side of the third cervical vertebra and the second cervical vertebra by 0.5 inch, as shown in figure 1, and then a large acupoint patch (containing penetration liquid) is covered on the cervical vertebra, as shown in figure 2, 10 days is a treatment course, and three treatment courses are continuous.

(2) Scapulohumeral periarthritis: the four acupoints of the shoulder mash, the megabone, the shoulder condyle and the shoulder glossy privet around the front and back of the shoulder joint are respectively stuck with small acupoint pastes as shown in figure 3, and then the large acupoint pastes are covered on the small acupoint pastes as shown in figure 4. According to the disease and cure standard, the treatment course lasts for 3 days, and 10 days is a treatment course.

(3) Lumbar vertebra disease: (comprising lumbar disc herniation, bulging, lumbar joint degeneration and lumbar vertebra hyperosteogeny) respectively and laterally opening 0.5 inch between the sacrum of the fifth lumbar vertebra, respectively attaching a small acupoint patch on the left and right sides, laterally opening 0.5 inch on the third and fourth lumbar vertebrae, respectively attaching a small acupoint patch on the left and right sides, laterally opening 0.5 inch on the first and second lumbar vertebrae, respectively attaching a small acupoint patch as shown in figure 5, and then covering a large acupoint patch as shown in figure 6.

(4) Knee arthritis (including knee degeneration and meniscus injury) is respectively attached with small acupoint patches at 4 acupoints of left and right knee eyes, beam hills and blood sea as shown in fig. 7, and then covered with large acupoint patches as shown in fig. 8. According to the disease and cure standard, the treatment course lasts for 3 days, and 10 days is a treatment course. When the patients use the acupoint powerful penetration method each time, the patients need to last for more than 10 hours, and medicine stopping is carried out for 2 days after each treatment course. Comparison group: the pain-relieving ointment (Henan Lingrui pharmaceutical Co., ltd.) with the specification of 7cmx10cm is used for 10 patients with pain in neck, shoulder, waist and leg, wherein the pain-relieving ointment has the effects of promoting qi circulation, removing blood stasis, warming channels, dispelling cold, relaxing tendons and activating collaterals, the Chinese medicinal standard character Z0000065 is applied to the corresponding parts of the patients with pain in neck, shoulder, waist and leg respectively for 1 paste/time and one day/time, and the acupoint selection standard of the acupoint powerful penetration method is referred for more than 10 hours. 10 days is a course of treatment, 3 courses of treatment are continued, and the course of treatment is two days at rest. 6. Standard of efficacy:

Symptoms before and after treatment for the patient: the pain points and the tenderness points of the affected parts, the physical symptoms, the activity of the affected parts and the like are improved, and all needs to be recorded and observed in detail. The main content is as follows:

(1) cervical spondylosis (including hyperosteogeny of cervical vertebra, degeneration of cervical bone and joint, prolapse of cervical intervertebral disc)

A. A pain point (1) of the neck, (2) a pressure pain point, (3) a neck muscle tension,

(4) a ribbon.

B. The activity degree (5) of the neck and symptoms brought by the activity; (2) scapulohumeral periarthritis: (isolation of rotator cuff tear by MRI diagnosis)

Around the A shoulder joint, (1) pain points, (2) pressure pain points, (3) tension of the lumbar muscle, and (4) cords;

B. the mobility (5) of the shoulder joint and symptoms caused by the movement.

(3) Lumbar vertebra diseases (including prolapse of lumbar intervertebral disc, bulging, lumbar joint degeneration and lumbar hyperosteogeny)

A: around the lumbar spine (1) pain points, (2) pressure pain points, (3) tension of lumbar muscles, (4) hip and thigh pain;

B. the mobility of lumbar vertebra (5) and symptoms caused by the movement (6);

C. straight leg elevation test (7) and autonomous leg mobility.

(4) Knee arthritis (including knee degeneration, meniscus injury) a, pain in the knee (1), tenderness around the knee (2);

B. The mobility of knee joint (3) and symptoms caused by the movement (4).

7. Judging curative effect standard:

cervical spondylosis patient

1. Cervical spondylosis cure standard:

a the pain point (1) of the neck, the pressure pain point (2) of the neck, the muscular tension of the neck, and the neck are all disappeared, and the string-shaped object is not reached.

B. The neck (5) has flexible movement degree up and down and left and right, and (6) has no discomfort after movement. The above 6 points all reach and judge the clinical cure.

2. Improvement criteria for cervical spondylosis:

A. the pain points (1) and the pressure points (2) of the neck are all disappeared, (3) the muscular tension of the neck is disappeared, (4) the neck is closed, and the string-shaped object is not reached.

B. The neck (5) has poor mobility, and the neck has poor mobility up and down and left and right, and the neck has a too large range of motion, namely local pain.

Results: observation group: 10 cervical spondylosis patients: 9 cases healed, 1 case improved;

comparison group: 10 cervical spondylosis patients: 5 cases were improved and 5 cases were effective.

Patient with scapulohumeral periarthritis

1. Cure standard for scapulohumeral periarthritis:

A. the pain points around the shoulder joint (1), the pressure pain points (2) and the tension sensation of the movement of the shoulder joint (3) are all disappeared, and the pain points around the shoulder joint (4) are not closed and are string-shaped.

B. The affected limb of the shoulder joint mobility (5) can be lifted upwards and is vertical to the body; (6) the left hand can reach the right shoulder blade from the front and the right shoulder blade from the back, and the right hand is the same as the right hand, so that no discomfort exists after the movement.

2. Improvement standard of scapulohumeral periarthritis:

A. the pain points around the shoulder joint (1), the pressure pain points (2) disappear, (3) the tension feeling of the shoulder joint movement still exists, and (4) the pain and the string-like objects around the shoulder joint can be performed.

B. The mobility of the shoulder joint (5) is such that the affected limb is raised up significantly before treatment but not perpendicular to the body, (6) the affected limb does not reach (from the front) the contralateral shoulder blade, nor does it reach from the rear.

3. Effective standard of scapulohumeral periarthritis:

A. the pain point around the shoulder joint (1) disappears, (2) the pressure pain point part exists, (3) the tension feeling of the shoulder joint movement still exists, and (4) the surrounding of the shoulder joint can be closed and the string-shaped object exists.

B. The mobility of the shoulder joint (5) is improved when the affected limb is lifted upwards compared with the prior treatment, and (6) the affected limb cannot reach the contralateral shoulder blade, and cannot reach the contralateral shoulder blade from the rear.

Results: observation group: 10 cases of scapulohumeral periarthritis patients: 7 cases are cured, 2 cases are improved, and 1 case is effective;

comparison group: 10 cases of scapulohumeral periarthritis patients: 3 cases were improved, 3 cases were valid, and 4 cases were invalid.

Lumbar vertebra disease patient

1. Cure standard of lumbar vertebra diseases (including lumbar disc herniation, bulging, lumbar joint degeneration and lumbar vertebra hyperosteogeny):

A. the pain points around the lumbar vertebra (1) disappear, (2) the pressure pain points disappear, (3) the lumbar muscle has no tension sense (4) the two sides of the lumbar muscle have no strip-shaped objects.

B. The mobility of lumbar vertebra (5) can be downward and can be touched to the toes without pain, and (6) the lumbar vertebra can be rotated left and right and can be turned backwards without uncomfortable feeling.

C. Straight leg elevation test: (7) (one) (8) the autonomous movement of the waist has no discomfort.

2. Improvement criteria for lumbar disease:

B. The mobility (5) of lumbar vertebra can be downward and touch the knee, and (6) the left and right rotation and the backward leaning range are not large, and the pain is felt when the left and right rotation and backward leaning range is slightly large.

C. Straight leg elevation test: (7) (earth) (8) lumbar autonomous movement is limited.

3. Effective standard of lumbar vertebra disease:

A. around the lumbar spine, (1) pain points, (2) pressure pain points exist, (3) the lumbar muscle is still tense, and (4) the two sides of the lumbar muscle can be palpated and the strip-shaped objects are on the two sides.

B. The lumbar vertebra (5) can not be rotated left and right or can not be bent backward when the user touches the knees.

Results: observation group: 10 lumbar patients: 9 cases cured, 1 case improved.

Comparison group: 10 lumbar patients: 5 cases were improved, 2 cases were valid, and 3 cases were invalid.

Knee arthritis patient

1. Cure criteria for knee arthritis (including knee degeneration, meniscus injury): A. the pain points of the knee joint (1) and the pain points around the knee joint (2) disappear. B. The knee joint (3) has the activity degree, and can rotate left and right and flex and stretch to reach the normal range (4) without pain.

2. Improvement criteria for knee arthritis:

A. the knee joint (1) the pain point disappears and (2) the pain point portion around the knee joint exists;

B. the knee joint (3) has better activity of rotating, flexing and stretching left and right than before treatment.

3. Effective criteria for knee arthritis:

a knee joint with (1) reduced pain points and (2) reduced pressure pain points around the knee joint; B. the knee joint (3) rotates left and right in activity, and the flexion and extension progress is not great compared with the prior treatment.

Results: observation group: 10 cases of knee arthritis patients: 7 cases healed, 3 cases improved; comparison group: 10 cases of knee arthritis patients: 4 cases were improved, 3 cases were valid, and 3 cases were invalid.

The curative effect is small: observation group: 10 cervical spondylosis patients: 9 cases cured, 1 case improved. The cure rate is 90 percent.

Comparison group: 10 cervical spondylosis patients: 5 cases were improved and 5 cases were effective. Has no cure rate.

Observation group: 10 cases of scapulohumeral periarthritis patients: 7 cases are cured, 2 cases are improved, and 1 case is effective. The cure rate is 70%;

comparison group: 10 cases of scapulohumeral periarthritis patients: 3 cases are improved, 3 cases are effective, 4 cases are ineffective, the cure rate is not available, the effective rate is 60%, and the ineffective rate is 40%.

Observation group: 10 lumbar patients: 9 cases are cured, 1 case is improved, and the cure rate is 90%;

comparison group: 10 lumbar patients: 5 cases were improved, 2 cases were valid, and 3 cases were invalid; the cure rate is no, and the inefficiency is 30%.

Observation group: 10 cases of knee arthritis patients: 7 cases are cured, 3 cases are improved, and the cure rate is 70%;

comparison group: 10 cases of knee arthritis patients: 4 cases are improved, 3 cases are effective, 3 cases are ineffective, the cure rate is no, and the inefficiency is 30%.

The invention can be seen that the acupoint powerful penetration method is effective and has no matter of cure rate, and the observation group is far beyond the comparison group.

Note that: in the test process, the two groups of patients are subjected to routine examination of blood, urine and stool, liver and kidney functions and electrocardiogram examination before and after treatment so as to evaluate the safety of the medicine, and no report of abnormality of the two groups of patients before treatment and after treatment is found, so that the acupoint powerful penetration method is safe.

Example 19

Clinical cases of Zhong Yi traditional Chinese medicine clinic 2021.6.15-2021.7.18 of Hunan Zhong Yi medical science and technology Co., ltd

1. 120 cases were treated. And observing the curative effect of the patients with shoulder, neck, waist and leg pain.

The method is divided into two groups according to a random number table method: group 60 was observed, comparative group 60. The two groups of age, sex, illness, etc. are comparable.

3. The diagnosed person:

(1) consciousness and consciousness can clearly express own opinion, subjective and objective symptoms, clear description and cooperation of physical examination.

(2) The age is above 20 years old and below 70 years old.

(3) Similar drugs and methods were not received prior to the trial.

(4) Informed about the study and consent.

(5) The participants had CT references as diagnostic basis except for the clinical diagnosis by the physician.

(6) For non-compliance with inclusion criteria: the patient can not receive the treatment according to the requirement, the curative effect can not be judged, or the curative effect and the safety can not be judged due to incomplete data.

4. Intervention measures

Test group: the invention is used: the acupoint powerful penetration method adopts the plaster of the example 1 at the main pain part, and adopts small plaster at the other small acupoints. For 60 patients with pains in neck, shoulder, waist and leg respectively, wherein 15 cases of cervical spondylosis (including cervical vertebra hyperosteogeny, cervical vertebra joint degeneration and cervical intervertebral disc protrusion); 15 cases of scapulohumeral periarthritis (rotator cuff tear separated by MRI diagnosis); 15 lumbar vertebra diseases (including lumbar disc herniation, bulging, lumbar vertebra joint degeneration and lumbar vertebra hyperosteogeny); knee arthritis 15 cases (knee degeneration, meniscus injury). The small acupoint patches (containing the penetration pill) are respectively placed at 0.5 inch beside the large vertebrae, 0.5 inch beside the fifth and fourth cervical vertebrae, and 0.5 inch beside the third and second cervical vertebrae; as shown in fig. 1. Then, the large acupoint plaster (containing penetration liquid) is covered on the upper surface of the cervical vertebra from the large vertebra to the first cervical vertebra as shown in figure 2. Three courses of treatment are adhered to. 10 days is a course of treatment, wherein one day of treatment can be rested.

Control group:

for 60 patients with pains in neck, shoulder, waist and leg, 15 patients with various diseases are treated by 'good doctor' bone pain tincture similar to the acupoint strong penetration plaster, and Chinese medicine standard Z53021244OTC (produced by Yunnan cloud medicine Co., ltd.) is respectively applied one plaster/time each day according to the corresponding parts (refer to acupoint selection method of the acupoint strong penetration plaster). Once per day. 10 days is a course of treatment, three courses of treatment are continued, rest for one day between courses of treatment, and each time lasts for more than 10 hours.

5. Standard of efficacy

Aiming at the improvement conditions of symptoms before and after treatment, pain points and tenderness points of an affected part, physical sign improvement, activity degree of a diseased part and the like of a patient, the following main contents are recorded and observed in detail:

1. cervical spondylosis (including hyperosteogeny of cervical vertebra, degeneration of cervical bone and joint, herniated disk of cervical vertebra)

a. Neck pain point (1), pressure pain point (2), neck muscle tension (3), neck muscle tension (4)

A rope around the portion.

b. The symptoms caused by the activities of the neck (5) and (6), such as pain, dizziness, etc.

2. Scapulohumeral periarthritis (rotator cuff tear separated by MRI diagnosis) a pain point around shoulder joint (1), (2) pressure pain point, (3) tension, and (4) string.

b. The symptoms caused by the movement of the shoulder joints (5) and (6), such as pain, etc.

3. Lumbar vertebra diseases (including lumbar disc herniation, lumbar vertebra joint degeneration, lumbar vertebra hyperosteogeny.)

a. Around the lumbar spine, (1) pain points, (2) pressure pain points, (3) tension of lumbar muscles, (4) hip pain and thigh pain,

b. the symptoms caused by the activities of the lumbar vertebrae (5) and (6), such as pain, etc. c. Straight leg elevation test (7), (8) autonomous mobility of legs.

4. Knee arthritis (including knee degeneration, meniscus injury) a. Pain in the knee, (1) tenderness around the knee, (2) tenderness around the knee. b. The knee joint has the movement degree (3) and the movement degree (4) and symptoms such as pain feeling are brought about.

6. Standard judgment of efficacy

Cervical spondylosis patient

And (I) curing the cervical spondylosis (including cervical hyperosteogeny, cervical joint degeneration and cervical intervertebral disc protrusion).

a. The pain points of the neck (1) and (2) disappear, (3) the muscular tension of the neck disappears, and (4) the neck is closed and the string-like object is not reached. b. Neck mobility: (5) flexible up and down, left and right, and (6) no uncomfortable feeling after activity. The clinical cure can be judged after the above 6 points are reached.

And (II) improvement standard of cervical spondylosis (including cervical vertebra hyperosteogeny, cervical vertebra joint degeneration and cervical intervertebral disc protrusion).

a. The pain points of the neck (1) and (2) disappear, (3) the muscular tension of the neck disappears, and (4) the neck is closed and the string-like object is not reached. And (5) the neck mobility, and the up, down, left and right movements do not reach the normal range.

(6) The movement range is too large, and pain is locally involved.

(III) effective Standard for cervical spondylosis

a. The pain points (1) and (2) of the neck disappear, (3) the neck muscles still feel tension, and (4) the neck can be closed and the ropes are shaped.

b. Neck mobility: the neck is involved in pain when the neck is movable in the vertical and horizontal directions with small ranges (5) and (6).

Results:

test group 15 cervical spondylosis patients: 13 cases are cured, 2 cases are improved, the cure rate is 86.6 percent,

the effective rate is 100%.

Control group: 15 cervical spondylosis patients, 5 patients are cured, 3 patients are improved, 4 patients are effective, and 3 patients are ineffective. The cure rate is 33.3%, the effective rate is 80%, and the inefficiency rate is 20%.

Patient with scapulohumeral periarthritis

Cure criteria of scapulohumeral periarthritis (rotator cuff tear isolated by MRI diagnosis) a pain point around shoulder joint (1), (2) vanishing of pressure pain point, (3) vanishing of tension sensation of shoulder joint movement, (4) absence of palpation around shoulder joint and tone rope. b. Shoulder joint mobility: (5) the affected limb may be raised up perpendicular to the body, (6) the patient may reach the contralateral shoulder blade from the front of the chest, (7) the patient may return to the contralateral shoulder blade from the back. The clinical cure can be judged if the above 7 points are all reached.

Improvement criteria of scapulohumeral periarthritis (rotator cuff tear isolated by MRI diagnosis a. Pain points around shoulder joint (1), (2) pain points disappear, (3) tension sensation of shoulder joint movement still exists, and (4) shoulder joint surrounding can be palpable and string-like substance. b. The movement degree of the shoulder joint (5) is obviously raised when the affected limb rises upwards than before treatment, but cannot be perpendicular to the body. (6) The patient cannot reach the contralateral shoulder blade from the anterior chest, (7) nor from the back.

(III), effective criteria for scapulohumeral periarthritis (separation of rotator cuff tear by MRI diagnosis)

b. The upward extension of the patient with the shoulder joint mobility (5) is improved compared with that before treatment, (6) the affected limb cannot reach the contralateral shoulder blade from the chest, and (7) the contralateral shoulder blade is more difficult to reach from the back.

Results: test group: 15 patients with scapulohumeral periarthritis (rotator cuff tear was isolated by MRI diagnosis) were cured in 11 cases and improved in 4 cases. The cure rate is 73.3 percent, and the effective rate is 100 percent.

Control group: 15 cases of scapulohumeral periarthritis patient (separated by MRI diagnosis of rotator cuff tear) 5

The cases were cured and 5 were improved. 5 cases were invalid. The cure rate is 33.3 percent, and the total effective rate is 53.3 percent. The inefficiency rate is 33.3%.

Lumbar vertebra disease patient

And (I) curing standard of lumbar vertebra diseases (comprising lumbar disc herniation, bulging, lumbar vertebra joint degeneration and lumbar vertebra hyperosteogeny).

a. The pain points (1) around the lumbar vertebra, the pressure pain points (2) disappear, the lumbar muscle is not tense,

(4) there are no chordae on either side of the psoas muscle.

b. The mobility of lumbar vertebra, (5) can be downward and can touch the toes without pain, (6) can rotate left and right and can be backward and can not feel uncomfortable.

c. In the straight leg lifting test (I) (7), the waist can move freely, and the clinical cure of lumbar spondylosis can be judged without any uncomfortable feeling (8) and above 8 points.

And (II) improvement standard of lumbar vertebra diseases (including lumbar disc herniation, bulging, lumbar vertebra joint degeneration and lumbar vertebra hyperosteogeny).

(4) there are no chordae on either side of the psoas muscle.

b. The mobility of lumbar vertebra, (5) can be touched downwards to the knee, (6) the left and right rotation and the backward leaning range are not large, and the pain is felt when the left and right rotation and backward leaning range is slightly large.

c. Straight leg elevation test (soil) (7), lumbar autonomous movement is limited.

(III) effective criteria for lumbar spondylosis

a. The pain points around the lumbar vertebrae (1) disappear, (2) the pressure pain points are partially present, (3) the lumbar muscle is still tense, and (4) the lumbar muscle can be closed on both sides and the strip-shaped objects.

Results: test group: 15 lumbar patients: 13 cases cured, 1 case improved. 1

The example works well. The cure rate is 86.7 percent, and the total effective rate is 100 percent.

Control group: 15 lumbar patients; 6 cases were cured and 3 cases were improved. 3 cases were invalid. The cure rate is 40%, the total effective rate is 80%, and the inefficiency rate is 20%.

Knee arthritis patient

Cure criteria for (one) knee arthritis (including knee degeneration, meniscus injury)

a. The pain points of the knee joint (1) and the pain points around the knee joint (2) disappear. b. The knee joint (3) rotates left and right in the activity degree, and the flexion and extension reach the normal range without pain. The clinical cure can be judged when the above 3 points are all reached.

And (II) improvement criteria for knee arthritis.

a. The knee joint (1) has its pain point disappeared and (2) a pressure pain point portion around the knee joint exists. b. The knee joint can rotate left and right, and the flexion and extension are improved compared with the prior treatment.

(III) effective criteria for knee arthritis.

a. The knee joint has (1) reduced pain points and (2) reduced pressure pain points around the knee joint. b. The knee joint (3) rotates left and right in activity, and the flexion and extension progress is not great compared with the prior treatment.

Results: a test group; 15 knee arthritis patients: 12 cases healed, 3 cases improved; the cure rate is 80 percent and the total effective rate is 100 percent.

Control group: 15 knee arthritis patients: 6 cases are cured, 5 cases are effective, and 4 cases are ineffective. The cure rate is 40%, the total effective rate is 73.3%, and the failure rate is 26.7%.

The curative effect is small: cervical spondylosis (including cervical vertebra hyperosteogeny, cervical vertebra joint degeneration, cervical intervertebral disc prolapse), scapulohumeral periarthritis (separated by MRI diagnosis to obtain rotator cuff tear), and lumbar spondylosis (including lumbar intervertebral disc prolapse, lumbar vertebra hyperosteogeny, lumbar vertebra joint degeneration).

The curative effect of the invention (acupoint powerful penetration patch) on knee arthritis (including knee degeneration and meniscus injury) is obviously higher than that of the invention (Kao doctor's Kao Tong Ling tincture, national medicine standard Z53021244OTC (produced by Yunnan cloud medicine Co., ltd.)

Note that: in the test process, two groups of patients are subjected to routine examination of blood, urine and stool, liver and kidney functions and electrocardiographic examination before and after treatment so as to evaluate the safety of the medicine. As a result, no report was found that both groups of patients were normal before treatment and abnormal after treatment. The 'acupoint powerful penetration method' of the invention is proved to be safe.

In summary, the curative effect advantages of the invention are as follows:

1. can be widely used for adults. The curative effect is exemplified by 33 years old of young people, 48 years old of middle-aged people and 75 years old people.

2. From the analysis of clinical cases, the curative effect is very satisfactory, the shortest time is three to four times, and the problem can be solved after a treatment course. The maximum treatment course is 10, and no effect is achieved at present in the case of treating neck, shoulder, waist and leg pains for more than ten years and 2800 cases.

3. Pain in the neck, shoulder, waist and legs is frequent, the age of the illness is also younger, and more than two kinds of pain exist in most patients. This is also true for pain in all of the neck, shoulder, waist, leg and general joints, such as rheumatoid arthritis. The powerful acupuncture point penetrating method is to apply the plaster to the most painful part with the big acupuncture point and to apply the plaster to other affected parts with the small acupuncture point. Such as: the pain of the patient is most serious, the pain of the patient can be mainly treated by applying the patch to the waist by using the big acupuncture points, and the pain of the other parts of the body can be applied by using the small acupuncture points according to the acupuncture points along the meridian and circulation route, so that the pain problem of multiple parts of the whole body can be solved simultaneously.

4. The acupoint powerful penetration method has the advantages of relatively simple operation, outstanding curative effect and low cost, can be widely applied to various pains of neck, shoulder, waist and leg of an adult, accords with the principles of simplicity, convenience, cheapness and inspection, and provides a prescription and plaster which are worthy of popularization for relieving pains.

Claims

1. The plaster is characterized by comprising, by weight, 90-110 parts of rhododendron molle, 40-60 parts of radix aconiti kusnezoffii, 40-60 parts of rhizoma arisaematis, 40-60 parts of rhizoma pinelliae, 90-110 parts of gleditsia sinensis, 40-60 parts of honeycomb, 40-60 parts of paniculate swallowwort root, 10-30 parts of borneol, 40-60 parts of white mustard seed, 40-60 parts of yellow pod pepper and 40-60 parts of cassia twig;

the small plaster comprises 5-15 parts of pills and 3-7 parts of fertilized protein; the pill is soaked semen Vaccariae.

2. The method for preparing a patch according to claim 1, comprising: coating 5-20mL of the medicine components on a plaster carrier, and then packaging to obtain a large plaster;

the preparation method of the medicine component comprises the following steps:

3. The preparation method according to claim 2, wherein in the step S1, the medicinal liquid is soaked in ethanol for 13-17d until the medicinal liquid is reddish-brown and has a strong and pungent smell.

4. The method of claim 2, wherein the ethanol is 70-80% ethanol.

5. The preparation method according to claim 2, wherein the borneol is added in the step S1,

the soaking is continued for 3-7d until the liquid medicine is reddish brown and has strong borneol smell.

6. The method according to claim 2, wherein the soaking time in step S2 is 15-25d until the medicinal liquid is orange.

7. The method of preparing the pill of claim 2, wherein the method of preparing the pill comprises:

mixing semen Sinapis Albae, yellow Capsici fructus, and ramulus Cinnamomi at a certain proportion, pulverizing, soaking in ethanol for 10-30d, adding semen Vaccariae, soaking for 3-7d, and taking out semen Vaccariae to obtain pill.

8. The preparation method according to claim 2, wherein the preparation method of the patch comprises the steps of: dipping fertilized protein, uniformly coating on plaster matrix, dipping 3-5 pills with shrub branches, and fixing on fertilized protein to obtain the small plaster.

9. The method of using a patch according to claim 2, comprising: the small plaster is applied to the acupoints along the meridian and collateral circulation path, and the large plaster is applied to the main pain part.