CN103432426B - Traditional Chinese medicinal tablets for treating neuralgic amyotrophy and preparation method thereof - Google Patents
Traditional Chinese medicinal tablets for treating neuralgic amyotrophy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition and a preparation method thereof. The traditional Chinese medicinal composition comprises the following main raw materials in proportion by weight: monkshood, gastrodia elata, cinnamon, clematis chinensis, astragalus, lily, polygala tenuifolia, earthworm and scorpion. The traditional Chinese medicinal composition has the curative effects of dispelling wind, removing obstruction in the meridians, relaxing muscles and stimulating blood circulation, supporting body resistance, tonifying qi, nourishing blood, and activating blood circulation, removing stasis and relieving pain, and has the advantages of remarkable effect and exact drug effect. The total effective rate of the traditional Chinese medicinal tablets can be 99 percent, and the traditional Chinese medicinal tablets have the effect of treating both principle and secondary aspects of diseases, and can avoid the relapse of disease after the disease is cured.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to and a kind ofly treat Chinese medicinal tablet of neuro-muscular atrophy and preparation method thereof.
background technology
Amyotrophy refers to striped muscle malnutrition, and the meat fiber muscle volume that causes such as even to disappear that attenuates reduces.The cause of disease mainly contains: neurogenic muscular atrophy, muscle-derived amyotrophy, muscular atrophy of disuse and other reasons amyotrophy.Muscle nutrition situation, except the pathological change of muscular tissue itself, more has substantial connection with nervous system.Diseases of spinal cord often causes muscular dystrophy and amyotrophy occurs.Amyotrophy patient is due to amyotrophy, myasthenia and long-term bed, and easy Complicating Pneumonia In Patients, decubital ulcer etc., bulbar paralysis symptom appears in Most patients in addition, forms great threat to patient vitals.Amyotrophy patient is except sending for a doctor except treatment, and oneself's medical treatment is very important.
Neuro-muscular atrophy is when neural impulse arrives, teleneuron release chemical mediator acetylcholine, the receptor on the latter and soleplate temporarily combines, and increases this place's sarolemma to the permeability of sodium, make extracellular Na+ion enter cell, thus make the transmembrane potential depolarization of endplate regions; Namely cause after reaching certain threshold value and sarolemma produces action potential around.Action potential is transmitted to sarcoplasmic reticulum, impels it to discharge calcium ion to sarcoplasm; The latter can impel adenosine triphosphate to decompose, and releases energy and some protein molecular in myocyte is closely agreed with, causing the contraction of myocyte's length.
The common reason of neuropathic muscular atrophy is useless use, malnutrition, ischemia and poisoning.Anterior angle pathological changes, nerve root, plexus nervorum, perineural amyotrophy
The conductive impairment that pathological changes etc. all can cause neural excitation to get excited, thus part muscle fiber is given up use, produce muscular atrophy of disuse.
On the other hand when after lower motor neuron any position infringement, the acetylcholine of its tip position release reduces, and sympathetic nerve Nutrition weakens and causes amyotrophy.Myogenicity amyotrophy is by the disease of muscle own, may also comprise some other factor, as the muscular dystrophy patient of shoulder belt or facio scapulo humeral type, turns out to be spinal muscular atrophy by morphological examination.
The Chinese medicinal tablet for the treatment of neuro-muscular atrophy is not also had in existing patent application.
Summary of the invention
A kind of Chinese medicinal tablet for the treatment of neuro-muscular atrophy is the invention provides for above problem, this Chinese medicinal tablet proves there is good therapeutic effect to the amyotrophy that neuro-muscular atrophy and a variety of causes cause by clinical treatment for many years, Chinese medicinal tablet of the present invention has dispelling wind and removing obstruction in the collateral, relaxing muscles and tendons to promote blood circulation, the body resistance strengthening and constitution consolidating, benefiting QI and nourishing blood, promoting blood circulation, removing blood stasis and relieving pain, has the advantage that Be very effective, drug effect are definite.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicinal tablet for neuro-muscular atrophy, take off the primary raw material stating weight proportion and be prepared from: Radix Aconiti 20-45 part, Rhizoma Gastrodiae 20-45 part, Cortex Cinnamomi 20-45 part, Radix Clematidis 20-45 part, Radix Astragali 30-50 part, Bulbus Lilii 30-50 part, Radix Polygalae 30-50 part, Pheretima 1-5 part, Scorpio 1-5 part.
Chinese medicinal tablet according to claim 1, preferred scheme is: its preferred version takes off the primary raw material stating weight proportion to be prepared from: Radix Aconiti 25-40 part, Rhizoma Gastrodiae 25-40 part, Cortex Cinnamomi 25-40 part, Radix Clematidis 25-40 part, Radix Astragali 35-45 part, Bulbus Lilii 35-45 part, Radix Polygalae 35-45 part, Pheretima 2-4 part, Scorpio 2-4 part.
Chinese medicinal tablet according to claim 1, the scheme be more preferably is: its preferred plan takes off the primary raw material stating weight proportion to be prepared from: Radix Aconiti 30 parts, 30 parts, Rhizoma Gastrodiae, Cortex Cinnamomi 30 parts, Radix Clematidis 30 parts, the Radix Astragali 35 parts, Bulbus Lilii 35 parts, Radix Polygalae 35 parts, Pheretima 3 parts, Scorpio 3 parts.
The preparation method of above-mentioned Chinese medicinal tablet, step is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in hot pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry when heaving to surperficial brown color is micro-, take out, sieve shakeout, spreading for cooling;
(2) decaptitated by Scorpio to truncate and soak 20-40 minute completely with vinegar, taking-up is dried, vinegar Scorpio;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 120-140 mesh sieve;
(4) cold water being preferably 30 DEG C by step step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio temperature soaks 2 hours, and water consumption is 2-5 times of described Pheretima (parched) and vinegar Scorpio weight;
(5) step (4) gained mixed liquor is heated to boiling, continue to filter after 1 hour, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(6) gained fine powder in step (3) is poured in the concentrated solution of step (5) gained, fully stir into thick paste; Thick paste is dried 1-2 hour, obtains drying object, dry at temperature is 70-90 DEG C;
(7) step (6) gains are measured according to 0.3-0.7g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet.
Described preparation method, preferred scheme is: step (2) is soaked 25-35 minute (preferably soaking 30 minutes).
Described preparation method, preferred scheme is: step (3) crosses 125-135 mesh sieve (preferred mistake 130 mesh sieve).
Described preparation method, preferred scheme is: step (4) water consumption be the 3-4 of described fine powder weight doubly (
Preferably 3.5 times).
Described preparation method, preferred scheme is: step (6) dries 1.3-1.8 hour (preferably 1.5 hours).
Described preparation method, preferred scheme is: step (6) dry at temperature is 75-85 DEG C (preferably dry at temperature 80 DEG C).
Described preparation method, preferred scheme is: the dosage form of step (7) tablet is 0.4-0.6g/ sheet (preferred dosage form is 0.5 g/ sheet).
Using method: for making the present invention reach optimum therapeuticing effect, take after 1 hour after meal, 3 times on the one, each 2-3 gram.
This Chinese medicinal tablet, to neuro-muscular atrophy Be very effective, has relaxing muscles and tendons to promote blood circulation, the body resistance strengthening and constitution consolidating, benefiting QI and nourishing blood, the feature of promoting blood circulation, removing blood stasis and relieving pain.
A kind of pharmacological effect for the treatment of each crude drug of Chinese medicinal tablet of neuro-muscular atrophy of the present invention is:
Radix Aconiti: pungent, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic.Have a pain for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type.Be used for the treatment of the disease such as anemofrigid-damp arthralgia, arthralgia.Take orally after the general process of preparing Chinese medicine.Radix Aconiti tincture external energy chafe, produces feeling of numbness then, therefore the outer analgesics being used as some neuralgia and rheumatism.
Rhizoma Gastrodiae: Gan Ping, returns Liver Channel.Endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral.
Cortex Cinnamomi: hide pungent, temperature.Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.For sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.
Radix Clematidis: pungent, salty, temperature, poisonous.Return urinary bladder channel.Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, knee joint cold type of pain, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.
The Radix Astragali: sweet, tepor.The Radix Astragali has effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating, raw by consolidating superficial resistance holder skin ulcer.
Bulbus Lilii: mind tranquilizing and the heart calming: Bulbus Lilii enters heart channel, cold nature, can clear away heart-fire relieving restlessness, mind tranquilizing and the heart calming, do not disappear for waste heat after calentura, lost in a reverie, insomnia and dreamful sleep, feel depressed, the disease such as susceptible to sorrow and being about to weep.
Radix Polygalae: bitter, pungent, tepor.GUIXIN, kidney, lung meridian.To calm the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm, detumescence insomnia and dreamful sleep, forgetful palpitation with fear, staring spells.Insomnia and dreamful sleep, severe palpitation, forgetful.Epilepsy mania and irritation, spasm is twitched, skin sore.
Scorpio: pungent is flat; Poisonous.Return Liver Channel.Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.
Pheretima: calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, the diseases such as hemiplegia.External is coated with the disease such as erysipelas, dermatitis rhus.
A kind of Chinese medicinal tablet for the treatment of neuro-muscular atrophy of the present invention meets the theory of the traditional Chinese medical science about dermatitis.For above-mentioned in a kind of defect for the treatment of in the Chinese medicinal tablet process of neuro-muscular atrophy, this product, on the basis of summing up forefathers' experience, goes through clinical research for many years, adopts natural Chinese medicines unique formula and technique to refine and forms.This product includes abundant plant biological active component, can directly act on affected part.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1treat a Chinese medicinal tablet for neuro-muscular atrophy, get the raw materials ready (getting 10g for every part) by following weight parts: Radix Aconiti 20, Rhizoma Gastrodiae 20, Cortex Cinnamomi 20, Radix Clematidis 20, the Radix Astragali 30, Bulbus Lilii 30, Radix Polygalae 30, Pheretima 1, Scorpio 1.
Treat a Chinese medicinal tablet for neuro-muscular atrophy, preparation process is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in hot pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry when heaving to surperficial brown color is micro-, take out, sieve shakeout, spreading for cooling;
(2) decaptitated by Scorpio to truncate and soak 20 minutes completely with vinegar, taking-up is dried, vinegar Scorpio;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 120 mesh sieves;
(4) cold water being preferably 30 DEG C by step step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio temperature soaks 2 hours, and water consumption is 2 times of described Pheretima (parched) and vinegar Scorpio weight;
(5) step (4) gained mixed liquor is heated to boiling, continue to filter after 1 hour, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(6) gained fine powder in step (3) is poured in the concentrated solution of step (5) gained, fully stir into thick paste; Thick paste is dried 1 hour, obtain drying object, dry at temperature is 70 DEG C;
(7) step (6) gains are measured according to 0.3g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet.
model case one: Zhao so-and-so, man, 23 years old, people from Harbin.Occur facial Hyperalgesia in February, 2010, bicker is sagging without reason, and neck is soft, the symptom that two lower limb are ached, and father and mother's a little Western medicine that gone to Chinese herbalist clinic to give out is returned application, and after medication, symptom improves, afterwards just drug withdrawal.General one month, there is numb limbs and tense tendons, the disease such as weak, tired in Zhao again, and sensation walking comparatively difficulty, the old sialorrhea of the corners of the mouth, speaking, some is unintelligible, and appetite declines, and other is without exception.Before Zhao does not have after continuing drug administration, treatment is so desirable, and not only do not control PD, the phenomenon of spasm and atrophy appears in muscle on the contrary, and what go examination in hospital just to learn trouble is muscular dystrophy thereupon.The head of a family recognizes the seriousness of morbid state, introduces and buys Chinese medicinal tablet of the present invention by friend, to take after 1 course for the treatment of above-mentioned symptom be improved significantly, the mental status is better, continue to take 2 courses for the treatment of of Chinese medicinal tablet of the present invention, above-mentioned symptom disappears substantially, without recurrence after drug withdrawal.
embodiment 2treat a Chinese medicinal tablet for neuro-muscular atrophy, get the raw materials ready (getting 10g for every part) by following weight parts: Radix Aconiti 45, Rhizoma Gastrodiae 45, Cortex Cinnamomi 45, Radix Clematidis 45, the Radix Astragali 50, Bulbus Lilii 50, Radix Polygalae 50, Pheretima 5, Scorpio 5.
Treat a Chinese medicinal tablet for neuro-muscular atrophy, preparation process is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in hot pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry when heaving to surperficial brown color is micro-, take out, sieve shakeout, spreading for cooling;
(2) decaptitated by Scorpio to truncate and soak 40 minutes completely with vinegar, taking-up is dried, vinegar Scorpio;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 140 mesh sieves;
(4) cold water being preferably 30 DEG C by step step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio temperature soaks 2 hours, and water consumption is 5 times of described Pheretima (parched) and vinegar Scorpio weight;
(5) step (4) gained mixed liquor is heated to boiling, continue to filter after 1 hour, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(6) gained fine powder in step (3) is poured in the concentrated solution of step (5) gained, fully stir into thick paste; Thick paste is dried 2 hours, obtain drying object, dry at temperature is 90 DEG C;
(7) step (6) gains are measured according to 0.7g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet.
embodiment 3:treat a Chinese medicinal tablet for neuro-muscular atrophy, get the raw materials ready (getting 10g for every part) by following weight parts: Radix Aconiti 25, Rhizoma Gastrodiae 25, Cortex Cinnamomi 25, Radix Clematidis 25, the Radix Astragali 35, Bulbus Lilii 35, Radix Polygalae 35, Pheretima 2, Scorpio 2.
Treat a Chinese medicinal tablet for neuro-muscular atrophy, preparation process is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in hot pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry when heaving to surperficial brown color is micro-, take out, sieve shakeout, spreading for cooling;
(2) decaptitated by Scorpio to truncate and soak 25 minutes completely with vinegar, taking-up is dried, vinegar Scorpio;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 125 mesh sieves;
(4) cold water being preferably 30 DEG C by step step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio temperature soaks 2 hours, and water consumption is 3 times of described Pheretima (parched) and vinegar Scorpio weight;
(5) step (4) gained mixed liquor is heated to boiling, continue to filter after 1 hour, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(6) gained fine powder in step (3) is poured in the concentrated solution of step (5) gained, fully stir into thick paste; Thick paste is dried 1.3 hours, obtain drying object, dry at temperature is 75 DEG C;
(7) step (6) gains are measured according to 0.4g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet.
model case two:journey, male, 23 years old, people from Changsha.Because " movable weak companion's amyotrophy more than 10 years " is admitted to hospital.Patient felt malaise without obvious cause in 5 years old time, and not without uncomfortable, since idiopathy, the weak symptom of patient increases the weight of gradually, occurred two lower limb muscles atrophy before 7 years, climb building difficulty, both hands can hold thing, can not complete fine movements such as writing, stop school work, over nearly 3 years, patient can not take care of oneself.Since morbidity, patient once arrived the famous hospital therapy of domestic many families, finally be diagnosed as neurotic atrophy, current without effective Therapeutic Method, purchase of coming after knowing Chinese medicinal tablet of the present invention is treated, after taking Chinese medicinal tablet 1 of the present invention course for the treatment of, both hands can take thing, do some simple actions, symptom after taking two courses for the treatment of before patient is improved substantially, and can by crutch station for a moment, continuing to take 2 courses for the treatment of of Chinese medicinal tablet of the present invention, is not transference cure, and can take care of oneself, be in the best of spirit.
embodiment 4treat a Chinese medicinal tablet for neuro-muscular atrophy, get the raw materials ready (getting 10g for every part) by following weight parts: Radix Aconiti 40, Rhizoma Gastrodiae 40, Cortex Cinnamomi 40, Radix Clematidis 40, the Radix Astragali 45, Bulbus Lilii 45, Radix Polygalae 45, Pheretima 4, Scorpio 4.
Treat a Chinese medicinal tablet for neuro-muscular atrophy, preparation process is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in hot pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry when heaving to surperficial brown color is micro-, take out, sieve shakeout, spreading for cooling;
(2) decaptitated by Scorpio to truncate and soak 35 minutes completely with vinegar, taking-up is dried, vinegar Scorpio;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 135 mesh sieves;
(4) cold water being preferably 30 DEG C by step step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio temperature soaks 2 hours, and water consumption is 4 times of described Pheretima (parched) and vinegar Scorpio weight;
(5) step (4) gained mixed liquor is heated to boiling, continue to filter after 1 hour, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(6) gained fine powder in step (3) is poured in the concentrated solution of step (5) gained, fully stir into thick paste; Thick paste is dried 1.8 hours, obtain drying object, dry at temperature is 85 DEG C;
(7) step (6) gains are measured according to 0.6g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet.
embodiment 5treat a Chinese medicinal tablet for neuro-muscular atrophy, get the raw materials ready (getting 10g for every part) by following weight parts: Radix Aconiti 30, Rhizoma Gastrodiae 30, Cortex Cinnamomi 30, Radix Clematidis 30, the Radix Astragali 35, Bulbus Lilii 35, Radix Polygalae 35, Pheretima 3, Scorpio 3.
Treat a Chinese medicinal tablet for neuro-muscular atrophy, preparation process is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in hot pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry when heaving to surperficial brown color is micro-, take out, sieve shakeout, spreading for cooling;
(2) decaptitated by Scorpio to truncate and soak 30 minutes completely with vinegar, taking-up is dried, vinegar Scorpio;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 130 mesh sieves;
(4) cold water being preferably 30 DEG C by step step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio temperature soaks 2 hours, and water consumption is 3.5 times of described Pheretima (parched) and vinegar Scorpio weight;
(5) step (4) gained mixed liquor is heated to boiling, continue to filter after 1 hour, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(6) gained fine powder in step (3) is poured in the concentrated solution of step (5) gained, fully stir into thick paste; Thick paste is dried 1.5 hours, obtain drying object, dry at temperature is 80 DEG C;
(7) step (6) gains are measured according to 0.5g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet.
test examplethe clinical practice of the Chinese medicinal tablet of embodiment 5 gained treatment neuro-muscular atrophy: in June, 2008 in December ,-2011, screen 120 routine patients in 4 hospitals, wherein women 58 example, male 62 example, oldest 72 years old, minimal ages 18 years old, 60 years old mean age.Before test 2 weeks, carry out Continuous Observation to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group takes embodiment 5 products obtained therefrom, and matched group takes other medicine.Using method is: (warm) taken three times a day, each 2-3 gram (adjusting to some extent depending on concrete condition), 15 days courses for the treatment of, take of the present invention simultaneously coordinate adhere to tempering 1 hour every day.Curative effect situation criterion: cure: take 3 courses for the treatment of of this product, amyotrophy degree is obviously improved, malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: to take a course for the treatment of of this product, amyotrophy degree is improved, and malaise symptoms alleviates or partial disappearance, and energy and muscle power strengthen; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 18-72 year neuro-muscular atrophy patient treatment outcome
| Experimental group | Matched group | |
| Number of cases | 100 | 20 |
| Male's number of cases | 52 | 10 |
| Women's number of cases | 48 | 10 |
| Age (year) | 18-72 | 18-72 |
| Clinical cure number of cases | 72 | 5 |
| Effective number of cases | 27 | 11 |
| Invalid number of cases | 1 | 4 |
| Total effective rate | 99% | 80% |
Therapeutic effect: cure 72 examples (72%), effective 27 examples (27%), invalid 1 example (1%), total effective rate 99%.Successful is better than matched group.
Take period self-induction symptom and physical change of spirit as shown in table 2.
Table 2:
The present invention selects Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii, Radix Polygalae, and Pheretima and Scorpio etc. carry out compatibility, produces synergism after making these drug regimens, can more effectively treat neuro-muscular atrophy.Take 10 days, more than 53% feel takes a turn for the better to some extent, and malaise symptoms improves; Take 20 days, more than 72% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 30 days, more than 97% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and the blood supply of electrocardio diagram coronary artery obviously improves, and some patients self-induction is fully recovered.Take more than 30 days in experimental group, effective percentage can reach 93%, and matched group is only 76%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (12)
1. treat a Chinese medicinal tablet for neuro-muscular atrophy, it is characterized in that: take off the raw material stating weight proportion and be prepared from: Radix Aconiti 20 parts, 20 parts, Rhizoma Gastrodiae, Cortex Cinnamomi 20 parts, Radix Clematidis 20 parts, the Radix Astragali 30 parts, Bulbus Lilii 30 parts, Radix Polygalae 30 parts, Pheretima 1 part, Scorpio 1 part.
2. the preparation method of Chinese medicinal tablet according to claim 1, it is characterized in that, step is as follows:
(1) Pheretima and wine are mixed thoroughly, slightly vexed, get sand and put in hot pot, fry to sliding sharp state, drop into Pheretima, constantly stir-fry when heaving to surperficial brown color is micro-, take out, sieve shakeout, spreading for cooling;
(2) decaptitated by Scorpio to truncate and soak 20-40 minute completely with vinegar, taking-up is dried, vinegar Scorpio;
(3) Radix Aconiti, Rhizoma Gastrodiae, Cortex Cinnamomi, Radix Clematidis, the Radix Astragali, Bulbus Lilii and Radix Polygalae are ground into smalls, cross 120-140 mesh sieve;
(4) cold water being preferably 30 DEG C by step (1) gained Pheretima (parched) and step (2) gained vinegar Scorpio temperature soaks 2 hours, and water consumption is 2-5 times of described Pheretima (parched) and vinegar Scorpio weight;
(5) step (4) gained mixed liquor is heated to boiling, continue to filter after 1 hour, gained concentrating filter liquor obtains concentrated solution to 1/2 of original volume;
(6) gained smalls in step (3) is poured in the concentrated solution of step (5) gained, fully stir into thick paste; Thick paste is dried 1-2 hour, obtains drying object, dry at temperature is 70-90 DEG C;
(7) step (6) gains are measured according to 0.3-0.7g/ sheet, be pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet.
3. preparation method according to claim 2, is characterized in that: step (2) soaks 25-35 minute.
4. preparation method according to claim 2, is characterized in that: step (2) is soaked 30 minutes.
5. preparation method according to claim 2, is characterized in that: step (3) crosses 125-135 mesh sieve.
6. preparation method according to claim 2, is characterized in that: step (3) crosses 130 mesh sieves.
7. preparation method according to claim 2, is characterized in that: step (6) dries 1.3-1.8 hour.
8. preparation method according to claim 2, is characterized in that: step (6) is dried 1.5 hours.
9. preparation method according to claim 2, is characterized in that: step (6) is dry at temperature 75-85 DEG C.
10. preparation method according to claim 2, is characterized in that: step (6) is dry at temperature 80 DEG C.
11. preparation methoies according to claim 2, is characterized in that: the dosage form of step (7) tablet is 0.4-0.6g/ sheet.
12. preparation methoies according to claim 2, is characterized in that: the dosage form of step (7) tablet is 0.5g/ sheet.
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| CN201410430026.XA Division CN104147396A (en) | 2013-09-13 | 2013-09-13 | Preparation method of traditional Chinese medicine tablet for treating neurogenic muscular dystrophy |
| CN201410429824.0A Division CN104173769A (en) | 2013-09-13 | 2013-09-13 | Preparation method of traditional Chinese medicine for treating neuralgic amyotrophy |
| CN201410429786.9A Division CN104162009A (en) | 2013-09-13 | 2013-09-13 | Method for preparing traditional Chinese medicine for treating neuralgic amyotrophy |
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| US20230263852A1 (en) * | 2019-10-10 | 2023-08-24 | Mthera Pharma Co., Ltd. | Composition For Preventing Or Treating Neurodegenerative Diseases Containing Mixed Herbal Extract Of Genkwae Flos, Clematidis Radix, And Gastrodiae Rhizoma |
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| CN102008622B (en) * | 2009-09-07 | 2012-06-27 | 周振西 | Traditional Chinese medicine for treating atrophy |
| CN102327492A (en) * | 2010-12-23 | 2012-01-25 | 陈玉堂 | Medicine for treating amyotrophia and myasthenia, myodystrophy and motor neuron injury |
| CN102284016B (en) * | 2011-07-15 | 2013-08-14 | 田杰仁 | Body resistance-strengthening and evil-eliminating internal and external therapy traditional Chinese medicine for treating rheumatism of muscles and bones |
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