CN103989854A - Traditional Chinese medicine preparation for treating ankylosing spondylitis and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating ankylosing spondylitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating ankylosing spondylitis and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The active ingredients of the traditional Chinese medicine preparation are prepared from the following raw materials in parts by weight: rhamnaceae, Chinese holly, cortex acanthopanacis, solanum lyratum, lycopodium clavatum, white silkworm larva, white semen brassicae, earthworm, radix achyranthis bidentatae, ground beetle, velvet antler, melastoma dodecandrum fruit, root of spinyleaf pricklyash, pothos chinensis, brooklet anemine root and ligusticum wallichii. The traditional Chinese medicine preparation is prepared from finely selected traditional Chinese medicine materials which have the effects of activating blood circulating to remove blood stasis, activating meridians to stop pain, relaxing the muscles, stimulate the bone and relieve swelling and pain. The traditional Chinese medicine preparation has the functions of promoting growth of essence, nourishing marrow, removing stasis to stimulate the menstrual flow and removing damp to stop pin, is convenient to use, good in absorption effect and free of adverse response and toxic and side effect, and clinical tests show that the preparation has good relieving and treating effect on ankylosing spondylitis and is applicable to popularization and application in clinical treatment and nursing of ankylosing spondylitis.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to a kind of Chinese medicine preparation and preparation method for the treatment of ankylosing spondylitis.
Background technology
Ankylosing spondylitis (AS) is the disease taking sacroiliac joint and spinal column attachment point inflammation as cardinal symptom.Be strong associated with HLA-B27.Certain micro-organisms (as klebsiella bacillus) has common antigen with susceptible person autologous tissue, can exception throw immunne response, the large joints of extremity, and annulus fibrosus disci intervertebralis and near connective fiberization thereof and ossified, and the ankylosis chronic inflammatory disease that is lesion characteristic.Ankylosing spondylitis belongs to rheumatism category, is the one of seronegative spondyloanthropathy.This disease cause of disease is still not clear, and is the chronic disease taking spinal column as major lesions position, involves sacroiliac joint, causes rigid spine and fibrosis, causes eye, lung, muscle, skeleton pathological changes in various degree, belongs to autoimmune disease.
Ankylosing spondylitis patient has arthropathy more, and first the overwhelming majority invades sacroiliac joint, the later up cervical vertebra that is developed to.A few patients is first invaded by cervical vertebra or several spinal column segment simultaneously, also can invade joint around, and there is inflammatory pain in joint, early lesion place, with periarticular muscle spasm, has stiff sense, and rise obviously morning.Also can show as night pain, through movable or take analgesic and alleviate.Along with PD, arthralgia alleviates, and each spinal column segment and joint motion are limited and lopsided, late period whole spinal column and lower limb become stiff arc, to pre-buckling.
For 16～25 years old youth, especially young man.The general onset of ankylosing spondylitis is relatively hidden, in early days can be without any clinical symptoms, some patient can show slight General Symptoms in early days, as weak, become thin, long-term or intermittent low grade fever, anorexia, anemia etc.Because the state of an illness is lighter, patient mostly can not early discovery, causes the state of an illness to be incured loss through delay, and loses best occasion for the treatment.
In clinical position, the patient of the ankylosing spondylitis of considerable part can't take care of oneself, agonizing, and often outbreak repeatedly.Because ankylosing spondylitis is a kind of chronic inflammatory disease, main sacroiliac joint, spinal column apophysis, the other soft tissue of spinal column and the periphery joint invaded, and the symptoms such as arthralgia that can occur together, main manifestations is waist, the back of the body, neck, buttocks, hip pain and arthralgia, can there is deformity of spine and ankylosis in severe patient, harm should not be underestimated.Although traditional Therapeutic Method is a lot, but mostly all can not effect a radical cure, finally cause worsening, bring great misery to patient, and existing medicine, circulation is slow, long-term taking can injure liver, kidney, stomach etc., therefore treat the necessary safety of medicine of ankylosing spondylitis, effectively, have no side effect, and Chinese materia medica is as the traditional medicine of China, there is effect strong, instant effect, the advantages such as lasting medicine, and there is no dependency, drug resistance and toxic and side effects, therefore select a kind of Chinese medicine preparation treatment ankylosing spondylitis, there is very important clinical meaning for treatment ankylosing spondylitis.
Summary of the invention
The invention provides a kind of Chinese medicine preparation and preparation method that is used for the treatment of ankylosing spondylitis, the Chinese crude drug prescription of selected blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, relaxing muscles and tendons bone alive, reducing swelling and alleviating pain is concocted, there is spermatogenesis to mend effect of marrow, eliminating blood stasis and inducing menstruation, removing damp and stopping pain, easy to use, good absorbing effect, without bad and toxic and side effects, through clinical verification, ankylosing spondylitis is had to fabulous alleviation and therapeutic effect, and the clinical treatment and the nursing that are suitable for ankylosing spondylitis are applied.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a Chinese medicine preparation for ankylosing spondylitis, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
54～84 parts of 56～86 parts of Herba Solani Lyratis of 58～88 parts of Radix Acanthopanacis Trifoliatis of 61～91 parts of Ramulus Kalopanacis seu Araliaes of Radix Berchemiae Giraldianae
41～71 parts of 43～73 parts of Pheretimas of 46～76 parts of Semen Sinapis Albaes of 51～81 portions of Bombyx Batryticatus of Herba Lycopodii
32～62 parts of 34～64 parts of Herba Melastomatis Dodecandri fruits of 36～66 parts of Cornu Cervi Pantotrichums of 39～69 parts of Eupolyphaga Seu Steleophagas of Radix Achyranthis Bidentatae
21～51 parts of 26～56 parts of Rhizoma Chuanxiongs of 27～57 parts of Radix Anemones Rivulariss of 31～61 parts of Herba Pothi Chinensis of Radix Zanthoxyli Spinifolii.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
76 parts of 78 parts of Herba Solani Lyratis of 80 parts of Radix Acanthopanacis Trifoliatis of 83 parts of Ramulus Kalopanacis seu Araliaes of Radix Berchemiae Giraldianae
63 parts of 66 parts of Pheretimas of 68 parts of Semen Sinapis Albaes of 73 portions of Bombyx Batryticatus of Herba Lycopodii
54 parts of 56 parts of Herba Melastomatis Dodecandri fruits of 58 parts of Cornu Cervi Pantotrichums of 62 parts of Eupolyphaga Seu Steleophagas of Radix Achyranthis Bidentatae
43 parts of 48 parts of Rhizoma Chuanxiongs of 49 parts of Radix Anemones Rivulariss of 53 parts of Herba Pothi Chinensis of Radix Zanthoxyli Spinifolii.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
69 parts of 71 parts of Herba Solani Lyratis of 73 parts of Radix Acanthopanacis Trifoliatis of 76 parts of Ramulus Kalopanacis seu Araliaes of Radix Berchemiae Giraldianae
56 parts of 59 parts of Pheretimas of 61 parts of Semen Sinapis Albaes of 66 portions of Bombyx Batryticatus of Herba Lycopodii
47 parts of 49 parts of Herba Melastomatis Dodecandri fruits of 51 parts of Cornu Cervi Pantotrichums of 55 parts of Eupolyphaga Seu Steleophagas of Radix Achyranthis Bidentatae
36 parts of 41 parts of Rhizoma Chuanxiongs of 42 parts of Radix Anemones Rivulariss of 46 parts of Herba Pothi Chinensis of Radix Zanthoxyli Spinifolii.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
62 parts of 64 parts of Herba Solani Lyratis of 65 parts of Radix Acanthopanacis Trifoliatis of 69 parts of Ramulus Kalopanacis seu Araliaes of Radix Berchemiae Giraldianae
49 parts of 51 parts of Pheretimas of 54 parts of Semen Sinapis Albaes of 59 portions of Bombyx Batryticatus of Herba Lycopodii
40 parts of 42 parts of Herba Melastomatis Dodecandri fruits of 44 parts of Cornu Cervi Pantotrichums of 45 parts of Eupolyphaga Seu Steleophagas of Radix Achyranthis Bidentatae
29 parts of 34 parts of Rhizoma Chuanxiongs of 34 parts of Radix Anemones Rivulariss of 39 parts of Herba Pothi Chinensis of Radix Zanthoxyli Spinifolii.
Treat a preparation method for the Chinese medicine preparation of ankylosing spondylitis, comprise following processing step:
(1) Radix Berchemiae Giraldianae, Herba Solani Lyrati, Bombyx Batryticatus, Herba Melastomatis Dodecandri fruit and Herba Pothi Chinensis are put in container, added the distilled water of 8～10 times of amounts, soak after 5～7 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 1～3 hour, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate for subsequent use;
(2) get Ramulus Kalopanacis seu Araliae, Herba Lycopodii, Radix Zanthoxyli Spinifolii and Radix Anemones Rivularis decontamination, microwave drying, smashs to pieces, is placed in mortar and grinds into powder, crosses 150 order fine powders, for subsequent use;
(3) after Radix Acanthopanacis Trifoliati being stir-fried with high heat for several times, surface uniform sprays yellow wine, after fried dry, pulverizes, and grinds into powder, crosses 170 order fine powders, for subsequent use;
(4) get Semen Sinapis Albae, Pheretima and Eupolyphaga Seu Steleophaga decontamination, dry, be placed in mortar and grind into powder, cross 200 order fine powders, for subsequent use;
(5) Radix Achyranthis Bidentatae, Cornu Cervi Pantotrichum and Rhizoma Chuanxiong are mixed thoroughly vexedly with saline, and with the micro-stir-fry of little fire, taking-up is dried, and are placed in mortar and grind into powder, cross 180 order fine powders, for subsequent use;
(6) by the filtrate of step (1) gained, make capsule with step (2), step (3), step (4) with the fine powder of step (5) gained, be the Chinese medicine preparation for the treatment of ankylosing spondylitis of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Radix Berchemiae Giraldianae: sweet in the mouth, micro-puckery, slightly warm in nature.Spleen reinforcing dampness removing, relaxing muscles and tendons and activating QI and blood in the collateral, menstruction regulating and pain relieving.For rheumatic arthritis, ankylosing spondylitis, weakness of the spleen and stomach, inappetence, traumatic injury, acute conjunctivitis.
Ramulus Kalopanacis seu Araliae: acrid in the mouth, property is flat, slightly poisonous.Chase after wind, promoting the circulation of blood.For rheumatic arthralgia, purple cloud wind, stomachache." detailed outline is picked up any lost article from the road " carries: " chase after wind analgesic therapy, have deep wonderful.For pathogenic wind toxic multiple abscess, migratory arthralgia, traumatic injury, labor is timid.Lower tire expedites the emergence of." modern medicine confirmation, Ramulus Kalopanacis seu Araliae has damp-clearing pain-relieving, chases after effect of wind analgesic therapy, is the important substance basis for the treatment of wind ankylosing spondylitis.
Radix Acanthopanacis Trifoliati: sweet in the mouth, hardship, warm in nature; Return liver, kidney, stomach warp.Heat-clearing and toxic substances removing, expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.Be used for catching a cold high hot, rheumatic arthritis, lithangiuria, traumatic injury, furuncle and phyma skin infection." conventional Chinese herbal medicine handbook " carries: " heat-clearing and toxic substances removing, expelling wind and removing dampness, the high hot osteodynia that cures cold, cough, chest pain, rheumatic arthritis, sciatica, lithangiuria." modern medicine confirms, Radix Acanthopanacis Trifoliati can be alleviated numb hand and foot, and waist knee joint flaccidity is soft, bones and muscles pain, myasthenia of limbs, the symptom of phlegm-fire dampness, makes to treat the important medical medical material of ankylosing spondylitis.
Herba Solani Lyrati: bitter in the mouth, cold nature, slightly poisonous; Return liver, stomach warp.Heat-clearing and toxic substances removing, inducing diuresis and reducing edema, anticancer.For jaundice due to damp-heat, ascites leucorrhea, carbuncle furuncle and phyma poison, rheumatic arthralgia.
Herba Lycopodii: bitter in the mouth, pungent, warm in nature.Return liver, spleen, kidney channel.Expelling wind and cold, dehumidifying detumescence, relaxing muscles and tendons to promote blood circulation.For anemofrigid-damp arthralgia, joint aches, skin numbness, tetraparesis, traumatic injury." the SHENGCAO property of medicine standby will " carries: " detumescence, except rheumatism.Infusing drugs in wine drink, relaxing muscles and tendons and activating QI and blood in the collateral.It effects a radical cure depressed pain, damage, and internal injury caused by metallic tool, removes phlegm and relieving cough.”
Bombyx Batryticatus: salty in the mouth, pungent, property is flat; Return liver, lung, stomach warp.Expelling wind for relieving convulsion, dissipating phlegm and resolving masses.For convulsion with spasms, laryngopharynx swelling and pain, skin pruritus, submandibular lymph nodes inflammation, facial paralysis.
Semen Sinapis Albae: acrid in the mouth, hot in nature; Return liver, spleen, lung, stomach warp.Promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain.For phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium, aphasia due to apoplexy, limbs arthralgia pain numbness, treating swelling and pain by traumatic injury." detailed outline " carries: " promoting the circulation of QI eliminating phlegm, in cold warming up, loose swollen pain relieving.Control and breathe heavily the regurgitation of coughing, numbness wood beriberi, muscles and bones waist saves all pains.”
Pheretima: salty in the mouth, cold in nature; Return liver, spleen, urinary bladder channel.Heat clearing away arresting convulsion, the diuresis of relievining asthma.For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia." Yunnan Chinese herbal medicine " carries: " hemostasia and promoting granulation, relaxing muscles and tendons and activating QI and blood in the collateral.”
Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is flat; Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " only waist knee joint is tingle for only muscles and bones pain, strong muscle relaxing muscles and tendons, removing blood stasis with potent drugs fetal abortion, and eliminating stagnation core, attacks scrofula, moves back carbuncle, mange, blood wind, psoriasis, pus nest.”
Eupolyphaga Seu Steleophaga: salty in the mouth, cold in nature, mild toxicity; Enter Liver Channel.Removing blood stasis, reunion of fractured tendons and bones.Cure mainly blood stasis amenorrhea, lump in the abdomen amasss piece, traumatic injury congestive edema, muscles and bones fracture, swollen and rigid tongue congenital deformity of the tongue.Carry according to " classification medical herbs " " control traumatic injury, bones and muscles pain due to rheumatism, detumescence, blows larynx disease." modern medicine study confirmation, Eupolyphaga Seu Steleophaga at least contains 17 seed amino acids, 28 kinds of trace element, and multiple alkaloid, malignant tumor is improved to the effect of symptom, can be used for regulating blood pressure, blood fat, thrombolytic, also has in addition the effects such as antiinflammatory, removing toxic substances, calmness.
Cornu Cervi Pantotrichum: sweet in the mouth, salty, warm in nature; Return kidney, Liver Channel.Invigorating kidney-YANG, benefiting essence-blood, bone and muscle strengthening, adjusts punching to appoint, holder sore.For sexual impotence spermatorrhea, cold womb is infertile, weakness and emaciation Mental fatigue, and fear of cold is dizzy, spinal column cold type of pain, muscles and bones flaccidity is soft." detailed outline " carries: " spermatogenesis is mended marrow, the Yiyang of nourishing blood, strong muscles and bones.Control that all are deficient, deafness, order is dark, dizzy, dysentery of deficiency type.”
Herba Melastomatis Dodecandri fruit: sweet in the mouth, warm in nature; Return kidney,liver,spleen.Kidney-replenishing blood-nourishing, arresting bleeding and miscarriage prevention.Be used for suffering from a deficiency of the kidney essence specially, soreness of the waist and knees, blood deficiency and yellow complexion, the deficiency of vital energy is weak, frequent fetal movement.
Radix Zanthoxyli Spinifolii: the taste heart, puckery, warm in nature.Expelling wind and cold, relaxing muscles and tendons to promote blood circulation, analgesia.For cough due to wind and cold, rheumatic numbness, traumatic injury, traumatic hemorrhage, constipation." Shaanxi Chinese herbal medicine " carries: " relaxing muscles and tendons to promote blood circulation, hemostasis, detumescence, analgesia.Control traumatic injury, traumatic hemorrhage, swelling and pain due to blood stasis.”
Herba Pothi Chinensis: lightly seasoned, property is flat.Expelling wind and removing dampness, promoting blood circulation to remove blood stasis, food dispersing cough suppressing.For traumatic injury, rheumatic arthritis, infantile malnutrition, fracture, otitis media, sinusitis." Traditional Chinese Medicine in Sichuan will " carries: " control children's's five kinds of child malnutrition, adult's cold to the marrow, not red pneumonedema, dampness flowing into joints, numb waits disease.And can cough-relieving, only pain due to disorder of QI.”
Radix Anemones Rivularis: acrid in the mouth, hardship, cold in nature, slightly poisonous.Clearing away heat-damp and promoting diuresis, reducing swelling and alleviating pain.For laryngopharynx swelling and pain, tonsillitis, toothache stomachache, acute hepatitis, chronic hepatitis, rheumatalgia, traumatic injury." Guizhou side's medicine among the people collection " carries: " control traumatic injury, can relaxing muscles and tendons to promote blood circulation, strong tonify deficiency.Control again dysentery, furuncle is controlled in external.”
Rhizoma Chuanxiong: bitter in the mouth, pungent, warm in nature; Return liver, spleen, tri-jiao channel.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Revolve for air-cooled headache dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, the twinge of the breast side of body, tumbling and swelling, rheumatic arthralgia." Japan hanako materia medica " carries: " control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, and strengthening bone and muscle, adjusts many arteries and veins, and broken Disorder knot stagnated blood, supports fresh blood, puts on flesh, and serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, scrofula wart is superfluous, skin ulcer scabies, and evacuation of pus repercussive blood.”
The present invention compared with prior art, has following beneficial effect:
The Chinese crude drug prescription of the selected blood circulation promoting and blood stasis dispelling of the present invention, removing obstruction in the collateral to relieve pain, relaxing muscles and tendons bone alive, reducing swelling and alleviating pain is concocted, there is spermatogenesis to mend effect of marrow, eliminating blood stasis and inducing menstruation, removing damp and stopping pain, easy to use, good absorbing effect, without bad and toxic and side effects, through clinical verification, ankylosing spondylitis is had to fabulous alleviation and therapeutic effect, the clinical treatment and the nursing that are suitable for ankylosing spondylitis are applied.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Radix Berchemiae Giraldianae 90g Ramulus Kalopanacis seu Araliae 87g Radix Acanthopanacis Trifoliati 85g Herba Solani Lyrati 83g
Herba Lycopodii 80g Bombyx Batryticatus 75g Semen Sinapis Albae 72g Pheretima 70g
Radix Achyranthis Bidentatae 68g Eupolyphaga Seu Steleophaga 65g Cornu Cervi Pantotrichum 63g Herba Melastomatis Dodecandri fruit 61g
Radix Zanthoxyli Spinifolii 60g Herba Pothi Chinensis 56g Radix Anemones Rivularis 55g Rhizoma Chuanxiong 50g.
The processing step of Chinese medicine preparation preparation method of the present invention is:
(1) Radix Berchemiae Giraldianae, Herba Solani Lyrati, Bombyx Batryticatus, Herba Melastomatis Dodecandri fruit and Herba Pothi Chinensis are put in container, added the distilled water of 8～10 times of amounts, soak after 5～7 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 1～3 hour, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate for subsequent use;
(2) get Ramulus Kalopanacis seu Araliae, Herba Lycopodii, Radix Zanthoxyli Spinifolii and Radix Anemones Rivularis decontamination, microwave drying, smashs to pieces, is placed in mortar and grinds into powder, crosses 150 order fine powders, for subsequent use;
(3) after Radix Acanthopanacis Trifoliati being stir-fried with high heat for several times, surface uniform sprays yellow wine, after fried dry, pulverizes, and grinds into powder, crosses 170 order fine powders, for subsequent use;
(4) get Semen Sinapis Albae, Pheretima and Eupolyphaga Seu Steleophaga decontamination, dry, be placed in mortar and grind into powder, cross 200 order fine powders, for subsequent use;
(5) Radix Achyranthis Bidentatae, Cornu Cervi Pantotrichum and Rhizoma Chuanxiong are mixed thoroughly vexedly with saline, and with the micro-stir-fry of little fire, taking-up is dried, and are placed in mortar and grind into powder, cross 180 order fine powders, for subsequent use;
(6) by the filtrate of step (1) gained, make capsule with step (2), step (3), step (4) with the fine powder of step (5) gained, be the Chinese medicine preparation for the treatment of ankylosing spondylitis of the present invention.
Usage and dosage: oral, warm water delivery service after meal, every day 3 times, the morning, noon and afternoon, respectively once each 2 15 days was a course for the treatment of, common 2～3 onsets course for the treatment of, pertinacious disease needs 5～6 courses for the treatment of.
Embodiment 2
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Radix Berchemiae Giraldianae 83g Ramulus Kalopanacis seu Araliae 80g Radix Acanthopanacis Trifoliati 78g Herba Solani Lyrati 76g
Herba Lycopodii 73g Bombyx Batryticatus 68g Semen Sinapis Albae 66g Pheretima 63g
Radix Achyranthis Bidentatae 62g Eupolyphaga Seu Steleophaga 58g Cornu Cervi Pantotrichum 56g Herba Melastomatis Dodecandri fruit 54g
Radix Zanthoxyli Spinifolii 53g Herba Pothi Chinensis 49g Radix Anemones Rivularis 48g Rhizoma Chuanxiong 43g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Radix Berchemiae Giraldianae 76g Ramulus Kalopanacis seu Araliae 73g Radix Acanthopanacis Trifoliati 71g Herba Solani Lyrati 69g
Herba Lycopodii 66g Bombyx Batryticatus 61g Semen Sinapis Albae 59g Pheretima 56g
Radix Achyranthis Bidentatae 55g Eupolyphaga Seu Steleophaga 51g Cornu Cervi Pantotrichum 49g Herba Melastomatis Dodecandri fruit 47g
Radix Zanthoxyli Spinifolii 46g Herba Pothi Chinensis 42g Radix Anemones Rivularis 41g Rhizoma Chuanxiong 36g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Radix Berchemiae Giraldianae 69g Ramulus Kalopanacis seu Araliae 65g Radix Acanthopanacis Trifoliati 64g Herba Solani Lyrati 62g
Herba Lycopodii 59g Bombyx Batryticatus 54g Semen Sinapis Albae 51g Pheretima 49g
Radix Achyranthis Bidentatae 45g Eupolyphaga Seu Steleophaga 44g Cornu Cervi Pantotrichum 42g Herba Melastomatis Dodecandri fruit 40g
Radix Zanthoxyli Spinifolii 39g Herba Pothi Chinensis 34g Radix Anemones Rivularis 34g Rhizoma Chuanxiong 29g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection:
The routine clinical observation of ankylosing spondylitis 380 of selecting my institute or outer court to make a definite diagnosis, patient is divided into two groups at random, treatment group 190 examples, wherein male's 93 examples, women's 97 examples, 15～63 years old age, 36 years old mean age, the course of disease 3 months～20 years, average 8.2 years.Matched group 190 examples, wherein male's 95 examples, women's 95 examples, 17～60 years old age, 38 years old mean age, the course of disease 5 months～21 years, average 7.6 years.
The course of disease, the degrees of symptoms of two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group patient takes Chinese medicine preparation of the present invention, oral, warm water delivery service after meal, and every day 3 times, the morning, noon and afternoon, respectively once each 2 15 days was a course for the treatment of, common 2～3 onsets course for the treatment of, pertinacious disease needs 5～6 courses for the treatment of.
Matched group Aspirin sheet, oral, 4～8 years old child, one time 0.5; 8-14 year child, one time 1; More than 14 years old child and adult, one time 1～2; Pertinacious disease patient, can interval 4-6 hour repeated drug taking 1 time, in 24 hours, is no more than 4 times.
3, efficacy determination:
(1) cure: the transference cures such as vertebra is stiff, bending is unfavorable, joint deformity; Take care of oneself, activity freely.
(2) effective: above-mentioned symptom is alleviated to some extent, takes care of oneself, and activity freely.
(3) invalid: disease is unchanged.
4, result:
Take in the treatment group of medicine of the present invention, cure 138 examples, imitate 37 examples, invalid 15 examples, cure rate 72.6%, total effective rate 92.1%.
In matched group, cure 51 examples, effective 90 examples, invalid 49 examples, cure rate 26.8%, total effective rate 74.2%.Model case is given an example:
Above result demonstration, treatment group cure rate and total effective rate are apparently higher than matched group.
1, what × ×, female, 57 direct labors, the new village people in Henan.Patient got injured by a fall lumbosacral region before 8 years, and the symptoms such as psoas muscle is stiff bitterly, vertebra is stiff, hyperosteogeny appear in rear diseases caused by exogenous pathogenic factor rheumatism then, light night in daytime is heavy, and increases the weight of gradually, once takes various pain relievings, detumescence medicine, effect is all not obvious, and my institute checked afterwards, was diagnosed as ankylosing spondylitis.The transference cures such as take after 3 courses for the treatment of of Chinese medicine preparation of the present invention, above symptom is obviously alleviated, and continues to use after 3 courses for the treatment of, and the stiff pain of psoas muscle, vertebra are stiff, livelihood restoration is normal.Follow up a case by regular visits to not recurrence so far.
2, Lu × ×, man, 45 years old, Enterprise Staff, Inner Mongol people from Chifeng.Patient causes psoas muscle portion pain after because of the wetland that dosses, does not stiffly relax 2 months, and night and morning rise heavier, stand up inconvenience, after activity, alleviate, once take the medicine such as indometacin, Rui Peilin, poor effect, the state of an illness slowly develops, and carrying out property increases the weight of, and is diagnosed as ankylosing spondylitis by my institute.Take after 3 courses for the treatment of of Chinese medicine preparation of the present invention, bilateral rumpbone joint aches, waist and sacrum pain obviously alleviate, and movable improvement continued to strengthen treatment after 2 months, and pain and stiff sense disappear, and spinal column is movable recovers normal.Follow up a case by regular visits to not recurrence so far.
3, execute × ×, man, 37 years old, builder, Shangrao, Jiangxi.Patient's waist pain, the pain increased afterwards, and breastbone pain, the difficulty of squatting down, once be diagnosed as ankylosing spondylitis, took the antirheumatic such as Rui Peilin, enteric coated aspirin, symptom has alleviation, but feels that in the recent period flank pain before increases the weight of, and unfavorable with the activity of waist hip, upper body such as can not directly play at the symptom.Take after 2 courses for the treatment of of Chinese medicine preparation of the present invention, symptom takes a turn for the better, continue to take after 3 courses for the treatment of, transference cure, activity freely, not recurrence.
4, open × ×, man, 34 years old, salesman, Zhejiang Jiaxing people.The frequent waist and sacrum pain of patient, the right gonalgia, rear waist and sacrum pain increases the weight of, and companion's waist is stiff, more so overcast and rainy, can not sitting standing for a long time, once alleviate from taking tablet for alleviating pain, pain respite, heavy when light when rear, be carrying out property and increase the weight of.Be diagnosed as ankylosing spondylitis by my institute.Take after 4 courses for the treatment of of Chinese medicine preparation of the present invention, symptom disappears completely, and freely, livelihood restoration is normal in activity.Follow up a case by regular visits to not recurrence so far.
5, hole × ×, female, 30 years old, civil servant, people from Baoding.Patient feels cervical region, flank pain often, and with deadlock in morning, time have uncomfortable in chest, night and tired after pain increase the weight of, many places, whole body joint pain.Be diagnosed as ankylosing arthritis.Take after 3 courses for the treatment of of Chinese medicine preparation of the present invention, symptom takes a turn for the better, and continues to take after 2 courses for the treatment of, and arthralgia symptom disappears, activity freely, not recurrence.
6, Cao × ×, man, 28 years old, designer, people from Jiujiang, Shanxi.There is waist and sacrum pain without obvious inducement in patient, with before rising morning for very, after the activity of getting up, symptom alleviates or disappears, and owing to not affecting work and life, and does not arouse attention.Above-mentioned symptom increases the weight of in the recent period, and occurs that double knee joint swells and ache, limitation of activity, stand up difficulty night, morning is stiff obviously, and limbs are miserable heavy, when overcast and rainy, pain increases the weight of, and obtains warm alleviation of pain, with soreness of the waist and knees, the symptoms such as fatigue and asthenia, Lai Wo institute checks, is diagnosed as ankylosing arthritis, take Chinese medicine preparation of the present invention, take after 2 courses for the treatment of, symptom obviously alleviates, continue to take after 3 courses for the treatment of, physical recovery is normal.
Claims (5)
1. a Chinese medicine preparation for the treatment of ankylosing spondylitis, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
54～84 parts of 56～86 parts of Herba Solani Lyratis of 58～88 parts of Radix Acanthopanacis Trifoliatis of 61～91 parts of Ramulus Kalopanacis seu Araliaes of Radix Berchemiae Giraldianae
41～71 parts of 43～73 parts of Pheretimas of 46～76 parts of Semen Sinapis Albaes of 51～81 portions of Bombyx Batryticatus of Herba Lycopodii
32～62 parts of 34～64 parts of Herba Melastomatis Dodecandri fruits of 36～66 parts of Cornu Cervi Pantotrichums of 39～69 parts of Eupolyphaga Seu Steleophagas of Radix Achyranthis Bidentatae
21～51 parts of 26～56 parts of Rhizoma Chuanxiongs of 27～57 parts of Radix Anemones Rivulariss of 31～61 parts of Herba Pothi Chinensis of Radix Zanthoxyli Spinifolii.
2. a kind of Chinese medicine preparation for the treatment of ankylosing spondylitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
76 parts of 78 parts of Herba Solani Lyratis of 80 parts of Radix Acanthopanacis Trifoliatis of 83 parts of Ramulus Kalopanacis seu Araliaes of Radix Berchemiae Giraldianae
63 parts of 66 parts of Pheretimas of 68 parts of Semen Sinapis Albaes of 73 portions of Bombyx Batryticatus of Herba Lycopodii
54 parts of 56 parts of Herba Melastomatis Dodecandri fruits of 58 parts of Cornu Cervi Pantotrichums of 62 parts of Eupolyphaga Seu Steleophagas of Radix Achyranthis Bidentatae
43 parts of 48 parts of Rhizoma Chuanxiongs of 49 parts of Radix Anemones Rivulariss of 53 parts of Herba Pothi Chinensis of Radix Zanthoxyli Spinifolii.
3. a kind of Chinese medicine preparation for the treatment of ankylosing spondylitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
69 parts of 71 parts of Herba Solani Lyratis of 73 parts of Radix Acanthopanacis Trifoliatis of 76 parts of Ramulus Kalopanacis seu Araliaes of Radix Berchemiae Giraldianae
56 parts of 59 parts of Pheretimas of 61 parts of Semen Sinapis Albaes of 66 portions of Bombyx Batryticatus of Herba Lycopodii
47 parts of 49 parts of Herba Melastomatis Dodecandri fruits of 51 parts of Cornu Cervi Pantotrichums of 55 parts of Eupolyphaga Seu Steleophagas of Radix Achyranthis Bidentatae
36 parts of 41 parts of Rhizoma Chuanxiongs of 42 parts of Radix Anemones Rivulariss of 46 parts of Herba Pothi Chinensis of Radix Zanthoxyli Spinifolii.
4. a kind of Chinese medicine preparation for the treatment of ankylosing spondylitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
62 parts of 64 parts of Herba Solani Lyratis of 65 parts of Radix Acanthopanacis Trifoliatis of 69 parts of Ramulus Kalopanacis seu Araliaes of Radix Berchemiae Giraldianae
49 parts of 51 parts of Pheretimas of 54 parts of Semen Sinapis Albaes of 59 portions of Bombyx Batryticatus of Herba Lycopodii
40 parts of 42 parts of Herba Melastomatis Dodecandri fruits of 44 parts of Cornu Cervi Pantotrichums of 45 parts of Eupolyphaga Seu Steleophagas of Radix Achyranthis Bidentatae
29 parts of 34 parts of Rhizoma Chuanxiongs of 34 parts of Radix Anemones Rivulariss of 39 parts of Herba Pothi Chinensis of Radix Zanthoxyli Spinifolii.
5. a preparation method for the Chinese medicine preparation of the treatment ankylosing spondylitis as described in claim 1～4, is characterized in that: comprise following processing step:
(1) Radix Berchemiae Giraldianae, Herba Solani Lyrati, Bombyx Batryticatus, Herba Melastomatis Dodecandri fruit and Herba Pothi Chinensis are put in container, added the distilled water of 8～10 times of amounts, soak after 5～7 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 1～3 hour, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate for subsequent use;
(2) get Ramulus Kalopanacis seu Araliae, Herba Lycopodii, Radix Zanthoxyli Spinifolii and Radix Anemones Rivularis decontamination, microwave drying, smashs to pieces, is placed in mortar and grinds into powder, crosses 150 order fine powders, for subsequent use;
(3) after Radix Acanthopanacis Trifoliati being stir-fried with high heat for several times, surface uniform sprays yellow wine, after fried dry, pulverizes, and grinds into powder, crosses 170 order fine powders, for subsequent use;
(4) get Semen Sinapis Albae, Pheretima and Eupolyphaga Seu Steleophaga decontamination, dry, be placed in mortar and grind into powder, cross 200 order fine powders, for subsequent use;
(5) Radix Achyranthis Bidentatae, Cornu Cervi Pantotrichum and Rhizoma Chuanxiong are mixed thoroughly vexedly with saline, and with the micro-stir-fry of little fire, taking-up is dried, and are placed in mortar and grind into powder, cross 180 order fine powders, for subsequent use;
(6) by the filtrate of step (1) gained, make capsule with step (2), step (3), step (4) with the fine powder of step (5) gained, be the Chinese medicine preparation for the treatment of ankylosing spondylitis of the present invention.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906284A (en) * | 2015-05-27 | 2015-09-16 | 饶烨 | Detumescence and acesodyne plaster and preparation method thereof |
| CN106075168A (en) * | 2016-08-22 | 2016-11-09 | 刘秋云 | A kind of Chinese and Western bound drug compositions treating ankylosing spondylitis and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101732433A (en) * | 2008-11-14 | 2010-06-16 | 张银红 | Chinese medicament for treating ankylosing spondylitis |
| CN103028066A (en) * | 2012-12-20 | 2013-04-10 | 周瑾 | Traditional Chinese medicine composition for treating ankylosing spondylitis |
| CN103316114A (en) * | 2013-07-09 | 2013-09-25 | 陈静静 | Traditional Chinese medicine for treating AS (Ankylosing Spondylitis) |
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- 2014-06-02 CN CN201410243502.7A patent/CN103989854A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732433A (en) * | 2008-11-14 | 2010-06-16 | 张银红 | Chinese medicament for treating ankylosing spondylitis |
| CN103028066A (en) * | 2012-12-20 | 2013-04-10 | 周瑾 | Traditional Chinese medicine composition for treating ankylosing spondylitis |
| CN103316114A (en) * | 2013-07-09 | 2013-09-25 | 陈静静 | Traditional Chinese medicine for treating AS (Ankylosing Spondylitis) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906284A (en) * | 2015-05-27 | 2015-09-16 | 饶烨 | Detumescence and acesodyne plaster and preparation method thereof |
| CN106075168A (en) * | 2016-08-22 | 2016-11-09 | 刘秋云 | A kind of Chinese and Western bound drug compositions treating ankylosing spondylitis and preparation method |
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Application publication date: 20140820 |