CN104906284A - Detumescence and acesodyne plaster and preparation method thereof - Google Patents

Abstract

The invention discloses a detumescence and acesodyne plaster. The detumescence and acesodyne plaster is prepared from, by weight, 16-18 parts of penthorum chinense pursh, 12-14 parts of acer palmatum thunb, 16-18 parts of decumbent bugle herbs, 10-12 parts of common caladium tubers, 8-10 parts of piper sarmentosum, 10-12 parts of polystichum deltodon, 12-14 parts of trifoliate acanthopanax root root-bark, 4-5 parts of beewax, 16-18 parts of tea-seed oil and 6-7 parts of medical stone. The detumescence and acesodyne plaster is prepared through the special formulation and process, has the effects of dissipating blood stasis, relieving pains, dispelling wind, removing dampness, resolving toxin and dispersing swelling, can be easily absorbed by patients and play the medicinal effect as a plaster for exterior application, is not liable to cause allergy or other reactions, and has a remarkable effect for relieving pains caused by rheumatism, rheumatoid arthritis, osteoproliferation, cervical or lumbar diseases, traumatic injuries and the like.

Description

A kind of discutient and analgesic plaster and preparation method thereof

Technical field

The invention belongs to Chinese drug preparation technique field, be specially a kind of discutient and analgesic plaster and preparation method thereof.

Background technology

ZHITONG GAO be a kind of by called optical imaging be used for specially treat anemofrigid-damp arthralgia, congestion numbness resistance passages through which vital energy circulates, limbs joint swells and ache, aversion to cold and cold limbs, local swelling has the diseases such as scleroma or ecchymosis, be particularly suitable for the people that those are sitting in the work and study of computer side for a long time, be sitting in the people before computer for a long time relative to those physical labourers, be more subject to the puzzlement of some chronic diseases, be similar to prolapse of lumbar intervertebral disc, arthritis, the disease of cervical spondylosis and so on, the health that threaten people all the time.

ZHITONG GAO is by Radix Aconiti Kusnezoffii, Radix Aconiti, Olibanum, Myrrha, Semen Strychni, Flos Caryophylli, Cortex Cinnamomi, Herba Schizonepetae, Radix Saposhnikoviae, geranium, Cortex Periplocae, Herba Centellae, Rhizoma Drynariae, the Radix Angelicae Dahuricae, Rhizoma Kaempferiae, Rhizoma Zingiberis, methyl salicylate, Mentholum, Borneolum Syntheticum, Camphora, liguidamber resinoid, Semen daturae fluid extract.Adjuvant is: the cooperation such as rubber, zinc oxide, Colophonium, lanoline, Yellow Vaselin, liquid Paraffin forms.General Western medicine analgesic has aspirin, ibuprofen, indometacin, acetaminophen, Phenylbutazone, rofecoxib, celecoxib etc.Analgesic is taken and too much can be caused gastrointestinal upset, chronic interstitial nephritis, necrosis of renal papillae, renal insufficiency etc.

Summary of the invention

The object of this invention is to provide a kind of discutient and analgesic plaster and preparation method thereof.

Discutient and analgesic plaster of the present invention; Be made up of the crude drug of following parts by weight: Penthorum chinense 16 ~ 18 parts, curled paralysis 12 ~ 14 parts, Ajuga macrosperma Wall. Ex Benth. 16 ~ 18 parts, Rhizoma Caladii Bicoloris 10 ~ 12 parts, clam beach wormwood 8 ~ 10 parts, to raw polystichun 10 ~ 12 parts, Radix Acanthopanacis Trifoliati 12 ~ 14 parts, 4 ~ 5 parts, Cera Flava, Oleum Camelliae 12 ~ 14 parts, Maifanitum 6 ~ 7 parts.

As optimization, this discutient and analgesic plaster is made up of the crude drug of following parts by weight: Penthorum chinense 17 parts, curled paralysis 13 parts, Ajuga macrosperma Wall. Ex Benth. 17 parts, Rhizoma Caladii Bicoloris 11 parts, clam beach wormwood 9 parts, to raw polystichun 11 parts, Radix Acanthopanacis Trifoliati 13 parts, 4 parts, Cera Flava, Oleum Camelliae 13 parts, Maifanitum 7 parts.

Prepare the method for this discutient and analgesic plaster, comprise the following steps:

A, by the Penthorum chinense of described parts by weight, curled paralysis, Ajuga macrosperma Wall. Ex Benth., Rhizoma Caladii Bicoloris, clam beach wormwood, raw polystichun, Radix Acanthopanacis Trifoliati to be mixed after being ground into 40 order granules, adopt carbon dioxide supercritical fluid extraction, extracting pressure is 35 ~ 40MPa, extraction temperature is 38 ~ 42 DEG C, extraction time is 100 ~ 105min, CO2 flow 20 ㎏/h;

B, by the Maifanitum of described parts by weight, make 400 object powder;

C, by the Oleum Camelliae of described parts by weight, be heated to 60 ~ 70 DEG C, the Cera Flava then adding described parts by weight stirs;

D, the powder added successively in the mixture of step c in step b, the extract mix homogeneously in step a.Put into gauze during use, spread on affected part.

In discutient and analgesic plaster prescription of the present invention, Penthorum chinense diuretic dehumidifies, stasis-dispelling and pain-killing; For jaundice, edema; Traumatic injury is controlled in external.Curled paralysis expelling wind and removing dampness, spleen invigorating is regulated the flow of vital energy, stasis-dispelling and pain-killing; For rheumatic arthritis, puerperal exposure to wind pain, puerperal abdonimal pain, bleed more than, dysmenorrhea, stomachache, stomachache, abdominal distention, dyspepsia, diarrhoea, oedema due to nephritis, traumatic injury.Ajuga macrosperma Wall. Ex Benth. clearing away heat and cooling blood; Eliminating stasis to stop pain; Main cough due to lung-heat; Spit blood; Epistaxis; Bloody dysentery; Drench pain; Rheumatic arthralgia; Treating swelling and pain by traumatic injury.Rhizoma Caladii Bicoloris removing toxic substances and promoting subsidence of swelling, eliminating stasis to stop pain; Dispelling the wind and dampness pathogens pain, treating swelling and pain by traumatic injury, stomachache, toothache, innominate toxic swelling, parotitis, carbuncle, skin ulcer, furuncle, tinea, eczema, whole body pruritus, Canis familiaris L. and Serpentis, insect bite are hindered, and weapons are hindered.Clam beach wormwood warming spleen and stomach for dispelling cold, expelling wind and removing dampness, reducing swelling and alleviating pain; For the cold pain of gastrointestinal, cough due to wind and cold, edema, malaria, toothache, rheumatic ostalgia, traumatic injury.Sour, puckery to raw polystichun, be slightly cold, promoting blood circulation and stopping pain, detumescence, diuresis, preventing cold; Traumatic injury is controlled in external, venom.Cera Flava detoxifies; Granulation promoting; Dysentery relieving; Hemostasis; Analgesic therapy; Main carbuncle carbuncle on the back, ulcer is for holding back; Anxious pained; Dysentery pus and blood; Incessant chronic diarrhea; Vaginal bleeding due to excessive movement of fetus; Seminal emission; Leukorrhagia.Radix Acanthopanacis Trifoliati heat-clearing and toxic substances removing, expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation; Cure cold high heat, cough with blood-flecked phlegm, rheumatic arthritis, jaundice, leucorrhea, lithangiuria, traumatic injury, furuncle and phyma skin infection.Oleum Camelliae has antiinflammatory, detumescence, the effect of pain relieving; Among the people also treatment with Oleum Camelliae is scalded and is burnt and tinea, the dermatosiss such as chronic eczema.Maifanitum is a kind of special nonmetal mineral resource, its likeness in form plaque-like yellow or in vain, quite like wheat grain; Medical stone powder enters Chinese medicine, and the water soaked can be drunk, and also for taking a shower, can have the drug effect of body-building and life lengthening.

Discutient and analgesic plaster of the present invention adopts special formulation and technique to be prepared from, and has effect of eliminating stasis to stop pain, expelling wind and removing dampness, removing toxic substances and promoting subsidence of swelling; Be easy to patient as external plaster use and absorb performance drug effect, and not easily cause irritated grade for reaction, pain effect can be caused very remarkable for rheumatism, rheumatoid arthritis, hyperosteogeny, neck, lumbar vertebra, traumatic injury etc.

Pertinent clinical data is as follows: physical data: in 192 cases, male 102 example, women 90 example; Oldest 59 years old, minimum 20 years old, wherein the most elder of the course of disease 17 years, the shortest 2 days.Two groups are divided into often to organize 96 examples at random.

Therapeutic Method: treatment group, according to the size of local pain area, gets ointment of the present invention appropriate, is spread out on white gauze, thick about 0.3cm ~ 0.5cm, external application affected part; Matched group, adopts QIZHENG XIAOTONG TIE cream, external application affected part; It within 5 days, is a course for the treatment of.

Criterion of therapeutical effect: recovery from illness: red, swollen, hot, bitterly disappearance, accompanying or adjacent joints activity is freely; Effective: red, swollen, heat disappears, and slightly aches, accompanying or adjacent joints activity is substantially not limited; Effective: red, swollen, hot, alleviation of pain is light, accompanying or adjacent joints activity is slightly limited; Invalid; Red, swollen, hot, pain nothing is improved, and joint motion is limited.After the course for the treatment of, two groups of case efficacy results are in table 1.

Detailed description of the invention

The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.

Embodiment 1, a, get Penthorum chinense 170 grams, curled paralysis 130 grams, Ajuga macrosperma Wall. Ex Benth. 170 grams, Rhizoma Caladii Bicoloris 110 grams, clam beach wormwood 90 grams, raw polystichun 110 grams, Radix Acanthopanacis Trifoliati 130 grams are mixed after being ground into 40 order granules, adopt carbon dioxide supercritical fluid extraction, extracting pressure is 35 ~ 40MPa, extraction temperature is 38 ~ 42 DEG C, extraction time is 100 ~ 105min, CO2 flow 20 ㎏/h; B, get Maifanitum 70 grams, make 400 object powder; C, extracting tea seed oil 130 grams, is heated to 60 ~ 70 DEG C, then adds 40 grams, Cera Flava and stirs; D, the powder added successively in the mixture of step c in step b, the extract mix homogeneously in step a, puts into gauze during use, spreads on affected part.

Embodiment 2, a, get Penthorum chinense 160 grams, curled paralysis 120 grams, Ajuga macrosperma Wall. Ex Benth. 160 grams, Rhizoma Caladii Bicoloris 100 grams, clam beach wormwood 80 grams, raw polystichun 100 grams, Radix Acanthopanacis Trifoliati 120 grams are mixed after being ground into 40 order granules, adopt carbon dioxide supercritical fluid extraction, extracting pressure is 35 ~ 40MPa, extraction temperature is 38 ~ 42 DEG C, extraction time is 100 ~ 105min, CO2 flow 20 ㎏/h; B, get Maifanitum 60 grams, make 400 object powder; C, extracting tea seed oil 120 grams, is heated to 60 ~ 70 DEG C, then adds 40 grams, Cera Flava and stirs; D, the powder added successively in the mixture of step c in step b, the extract mix homogeneously in step a, puts into gauze during use, spreads on affected part.

Embodiment 3, a, get Penthorum chinense 180 grams, curled paralysis 140 grams, Ajuga macrosperma Wall. Ex Benth. 180 grams, Rhizoma Caladii Bicoloris 120 grams, clam beach wormwood 100 grams, raw polystichun 120 grams, Radix Acanthopanacis Trifoliati 140 grams are mixed after being ground into 40 order granules, adopt carbon dioxide supercritical fluid extraction, extracting pressure is 35 ~ 40MPa, extraction temperature is 38 ~ 42 DEG C, extraction time is 100 ~ 105min, CO2 flow 20 ㎏/h; B, get Maifanitum 70 grams, make 400 object powder; C, extracting tea seed oil 140 grams, is heated to 60 ~ 70 DEG C, then adds 50 grams, Cera Flava and stirs; D, the powder added successively in the mixture of step c in step b, the extract in step a, tween 80 0.4 gram of mix homogeneously, puts into gauze during use, spreads on affected part.

Claims (3)

1. a discutient and analgesic plaster; It is characterized in that by following parts by weight crude drug make: Penthorum chinense 16 ~ 18 parts, curled paralysis 12 ~ 14 parts, Ajuga macrosperma Wall. Ex Benth. 16 ~ 18 parts, Rhizoma Caladii Bicoloris 10 ~ 12 parts, clam beach wormwood 8 ~ 10 parts, to raw polystichun 10 ~ 12 parts, Radix Acanthopanacis Trifoliati 12 ~ 14 parts, 4 ~ 5 parts, Cera Flava, Oleum Camelliae 12 ~ 14 parts, Maifanitum 6 ~ 7 parts.

2. discutient and analgesic plaster according to claim 1; It is characterized in that being made up of the crude drug of following parts by weight: Penthorum chinense 17 parts, curled paralysis 13 parts, Ajuga macrosperma Wall. Ex Benth. 17 parts, Rhizoma Caladii Bicoloris 11 parts, clam beach wormwood 9 parts, to raw polystichun 11 parts, Radix Acanthopanacis Trifoliati 13 parts, 4 parts, Cera Flava, Oleum Camelliae 13 parts, Maifanitum 7.

3. prepare a method for discutient and analgesic plaster described in claim 1, it is characterized in that comprising the following steps:

A, by the Penthorum chinense of described parts by weight, curled paralysis, Ajuga macrosperma Wall. Ex Benth., Rhizoma Caladii Bicoloris, clam beach wormwood, raw polystichun, Radix Acanthopanacis Trifoliati to be mixed after being ground into 40 order granules, adopt carbon dioxide supercritical fluid extraction, extracting pressure is 35 ~ 40MPa, extraction temperature is 38 ~ 42 DEG C, extraction time is 100 ~ 105min, CO2 flow 20 ㎏/h;

B, by the Maifanitum of described parts by weight, make 400 object powder;

C, by the Oleum Camelliae of described parts by weight, be heated to 60 ~ 70 DEG C, the Cera Flava then adding described parts by weight stirs;

D, the powder added successively in the mixture of step c in step b, the extract mix homogeneously in step a.