CN104922568A - Compound oil capable of relieving pain and preparation method thereof - Google Patents

Abstract

The invention discloses compound oil capable of relieving pain. The compound oil is prepared from the following raw materials in parts by weight: 13-15 parts of vernonia cumingiana, 15-18 parts of hypericum patulum, 18-20 parts of peperomia pellucid, 10-12 parts of root of little leaf dogwood, 20-22 parts of panax zingiberensis, 13-15 parts of morinda parvifolia, 10-12 parts of pomegranate seeds, 4-5 parts of borneol and 18-20 parts of linseed oil. The compound oil capable of relieving pain is prepared by special formula and process; the compound oil is remarkable in synergistic effect and has the functions of relaxing tendons and activating collaterals, removing stasis to ease pain, removing toxicity and treating sore, dispelling the wind and resolving dampness, resisting bacteria and diminishing inflammation; when the compound oil is used as pain-relieving oil, the oil is easily absorbed by the patients, the pharmacological effect is exerted, and the reaction such as irritability is not liable to cause; the compound oil is quite obvious in effect of relieving pain caused by arthritis, hyperostosis, cervical injury, lumber injury and traumatic injury; the compound oil also has an excellent treatment effect on burn wounds.

Description

A kind of pain relieving compound oil and preparation method thereof

Technical field

The invention belongs to Chinese drug preparation technique field, be specially a kind of pain relieving compound oil and preparation method thereof.

Background technology

Often human body can be caused to have congestion and swelling pain phenomenon because of a variety of causes in life, this time, reducing swelling and alleviating pain was extremely important timely, because only in this way just can promote the recovery as early as possible of damaged part.Stand direct wound, or the tissue of wound and long-term strain indirectly, there is microcirculation disturbance.Due to capillary wall sepage or hemorrhage, cause the formation of the hypostasis thing of tissue, and there occurs aseptic inflammation, cause swollen tissue pain.If the absorption of hypostasis thing can not be impelled, adhesion will be produced.Can there is ischemic contracture in the adhesion of muscle, tendon, the adhesion outside intraarticular just causes the tetanic of joint.

ZHENGHONGHUA YOU complicated component, contains white oil, white camphor oil, laurel oil, oleum Terebinthinae, cinnamic aldehyde, wintergreen oil, what have also contains Sanguis Draxonis etc.ZHENGHONGHUA YOU is mainly used in pain relieving of helping meet an urgent need, anti-inflammation hemostasia.Discovered in recent years, ZHENGHONGHUA YOU likely cause erythra, contact dermatitis, purpura and even serious epidermolysis bullosa and anaphylactic shockdeng untoward reaction.

The major function of YUNNAN BAIYAO is hemostasis wound healing, silt is dispelled in treating blood disorders, Repercusion analgesia, toxin expelling remove pus etc.Be widely used in traumatic injury clinically, wound hemorrhage, congestion swell and ache, hematemesis spitting of blood, women metrorrhagiaand the disease such as red and swollen skin infection.Anemia of pregnant woman can not take this product; During taking YUNNAN BAIYAO, diet semen Viciae fabae, fish, pungent, the acid irritable food such as cold.

Summary of the invention

The object of this invention is to provide a kind of pain relieving compound oil and preparation method thereof.

Pain relieving compound oil of the present invention; Be made up of the crude drug of following parts by weight: Caulis Vernoniae Andersonii 13 ~ 15 parts, Herba Hyperici Patuli 15 ~ 18 parts, Herba Peperomiae pellucidae 18 ~ 20 parts, Radix Corni Paucinervis 10 ~ 12 parts, Radix Camptandrae Yunnanensis 20 ~ 22 parts, Herba Morindae Parvifoliae 13 ~ 15 parts, Semen Granati 10 ~ 12 parts, Borneolum Syntheticum 4 ~ 5 parts, Semen Lini oil 18 ~ 20 parts.

As optimization, this pain relieving compound oil, is made up of the crude drug of following parts by weight: Caulis Vernoniae Andersonii 14 parts, Herba Hyperici Patuli 16 parts, Herba Peperomiae pellucidae 19 parts, Radix Corni Paucinervis 11 parts, Radix Camptandrae Yunnanensis 21 parts, Herba Morindae Parvifoliae 14 parts, Semen Granati 11 parts, Borneolum Syntheticum 4 parts, Semen Lini oil 19 parts.

Prepare the method for this pain relieving compound oil, comprise the following steps:

A, the Caulis Vernoniae Andersonii of described parts by weight, Herba Hyperici Patuli, Herba Peperomiae pellucidae, Radix Corni Paucinervis, Radix Camptandrae Yunnanensis, Herba Morindae Parvifoliae, Semen Granati to be mixed after being ground into 40 order granules, adopt carbon dioxide supercritical fluid extraction, extracting pressure is 35 ~ 40MPa, extraction temperature is 38 ~ 42 DEG C, extraction time is 100 ~ 105min, CO2 flow, 20 ~ 30kg/h;

B, by the Borneolum Syntheticum of described parts by weight, make 400 object powder;

C, by the Semen Lini oil of described parts by weight, be heated to 60 ~ 70 DEG C, add the powder in step b successively, the extract mix homogeneously in step a.According to the size of local pain area, get pain relieving compound oil of the present invention appropriate, be applied in affected part.

In pain relieving compound oil prescription of the present invention, Caulis Vernoniae Andersonii expelling pathogenic wind from the body surface; Relaxing muscles and tendons and activating QI and blood in the collateral; Main flu; Malaria; Laryngalgia; Toothache; Wind-fire acute conjunctivitis; Rheumatic arthralgia; Lumbar muscle strain; Traumatic injury.

Herba Hyperici Patuli clearing away heat-damp and promoting diuresis detoxifies; Dispersing the stagnated liver-QI and dredging collateral; Stasis-dispelling and pain-killing.Main damp and hot gonorrhea; Hepatitis; Flu; Tonsillitis; The hernia swelling and hanging down of either of the testes; Bones and muscles pain; Traumatic injury.

Herba Peperomiae pellucidae eliminating stasis to stop pain; Heat-clearing and toxic substances removing; Main carbuncle sore tumefacting virus; Burn and scald; Traumatic injury; Traumatic hemorrhage.

Radix Corni Paucinervis clearing away heat and expelling pathogen in the exterior; Detoxification sore treatment; Main headache due to common cold; Beriberoid pyretic arthralgia; Diarrhoea; Injury and bone fracture; Traumatic hemorrhage; Hot carbuncle toxin; Burn and scald.

Radix Camptandrae Yunnanensis promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain; For traumatic injury, rheumatic ostalgia, hematemesis and epistaxis, menorrhagia; Worm venom is controlled in external, traumatic hemorrhage.

The polyphenol extract of Semen Granati is a class powerful antioxidant, its contribute to promoting capillary tube vigor and strengthen capillary wall, improve skin smooth and elasticity, alleviate diabetic renal papillary necrosis and improve vision, alleviate varicosis, help improve brain function, antagonism arthritic inflammation less trouble phlebitis risk.

Borneolum Syntheticum leads to all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain; Control apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is nebula film also, enterobiasis.

Herba Morindae Parvifoliae heat-clearing and toxic substances removing, eliminating stasis to stop pain, removing dampness of dispeling the wind; Control dyspepsia, diarrhoea, constipation, cold cough, osteopatia sprain, lumbar muscle strain.

Semen Lini oil unsaturated fatty acid content is high, has excellent affinity and penetration to skin, and the multiple fatty acid contained by it is easily absorbed by the skin, and Semen Lini oil can play antiinflammatory and anti-proliferative effect.

Pain relieving compound oil of the present invention adopts special formulation and technique to be prepared from, and synergism is given prominence to, and has effect of relaxing muscles and tendons and activating QI and blood in the collateral, stasis-dispelling and pain-killing, detoxification sore treatment, removing dampness of dispeling the wind, anti-inflammation; Be easy to patient as the use of pain relieving oil and absorb performance drug effect, and not easily cause irritated grade for reaction, pain effect can be caused very remarkable for arthritis, hyperosteogeny, neck, lumbar vertebra, traumatic injury etc., also have good curative effect for burn wound.

Detailed description of the invention

The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.

Embodiment 1, a, get Caulis Vernoniae Andersonii 140 grams, Herba Hyperici Patuli 160 grams, Herba Peperomiae pellucidae 190 grams, Radix Corni Paucinervis 110 grams, Radix Camptandrae Yunnanensis 210 grams, Herba Morindae Parvifoliae 140 grams, Semen Granati 110 grams mix after being ground into 40 order granules, adopt carbon dioxide supercritical fluid extraction, extracting pressure is 35 ~ 40MPa, extraction temperature is 38 ~ 42 DEG C, extraction time is 100 ~ 105min, CO2 flow, 20 ~ 30kg/h; B, get Borneolum Syntheticum 40 grams, make 400 object powder; C, get Semen Lini oil 190 grams, be heated to 60 ~ 70 DEG C, add the powder in step b successively, the extract mix homogeneously in step a.According to the size of local pain area during use, get pain relieving compound oil of the present invention appropriate, be applied in affected part.

Embodiment 2, a, get Caulis Vernoniae Andersonii 130 grams, Herba Hyperici Patuli 150 grams, Herba Peperomiae pellucidae 180 grams, Radix Corni Paucinervis 100 grams, Radix Camptandrae Yunnanensis 200 grams, Herba Morindae Parvifoliae 130 grams, Semen Granati 100 grams mix after being ground into 40 order granules, adopt carbon dioxide supercritical fluid extraction, extracting pressure is 35 ~ 40MPa, extraction temperature is 38 ~ 42 DEG C, extraction time is 100 ~ 105min, CO2 flow, 20 ~ 30kg/h; B, get Borneolum Syntheticum 40 grams, make 400 object powder; C, get Semen Lini oil 180 grams, be heated to 60 ~ 70 DEG C, add the powder in step b successively, the extract in step a, tween 80 0.5 gram of mix homogeneously.According to the size of local pain area during use, get pain relieving compound oil of the present invention appropriate, be applied in affected part.

Embodiment 3, a, get Caulis Vernoniae Andersonii 150 grams, Herba Hyperici Patuli 180 grams, Herba Peperomiae pellucidae 200 grams, Radix Corni Paucinervis 120 grams, Radix Camptandrae Yunnanensis 220 grams, Herba Morindae Parvifoliae 150 grams, Semen Granati 120 grams mix after being ground into 40 order granules, adopt carbon dioxide supercritical fluid extraction, extracting pressure is 35 ~ 40MPa, extraction temperature is 38 ~ 42 DEG C, extraction time is 100 ~ 105min, CO2 flow, 20 ~ 30kg/h; B, get Borneolum Syntheticum 50 grams, make 400 object powder; C, get Semen Lini oil 200 grams, be heated to 60 ~ 70 DEG C, add the powder in step b successively, the extract mix homogeneously in step a.According to the size of local pain area during use, get pain relieving compound oil of the present invention appropriate, be applied in affected part.

Pertinent clinical data is as follows: physical data: in 234 cases, male 135 example, women 99 example; Oldest 62 years old, minimum 16 years old, wherein the most elder of the course of disease 15 years, the shortest 1 day.Two groups are divided into often to organize 117 examples at random.

Therapeutic Method: treatment group, according to the size of local pain area, gets pain relieving compound oil of the present invention appropriate, is applied in affected part; Matched group, adopts safflower oil, is applied in affected part; Every day three times six days is a course for the treatment of.

Criterion of therapeutical effect: recovery from illness: red, swollen, hot, bitterly disappearance, accompanying or adjacent joints activity is freely; Effective: red, swollen, heat disappears, and slightly aches, accompanying or adjacent joints activity is substantially not limited; Effective: red, swollen, hot, alleviation of pain is light, accompanying or adjacent joints activity is slightly limited; Invalid; Red, swollen, hot, pain nothing is improved, and joint motion is limited.After the course for the treatment of, two groups of case efficacy results are in table 1.

Claims (3)

1. a pain relieving compound oil; It is characterized in that being made up of the crude drug of following parts by weight: Caulis Vernoniae Andersonii 13 ~ 15 parts, Herba Hyperici Patuli 15 ~ 18 parts, Herba Peperomiae pellucidae 18 ~ 20 parts, Radix Corni Paucinervis 10 ~ 12 parts, Radix Camptandrae Yunnanensis 20 ~ 22 parts, Herba Morindae Parvifoliae 13 ~ 15 parts, Semen Granati 10 ~ 12 parts, Borneolum Syntheticum 4 ~ 5 parts, Semen Lini oil 18 ~ 20 parts.

2. according to claim a kind of pain relieving compound oil, it is characterized in that being made up of the crude drug of following parts by weight: Caulis Vernoniae Andersonii 14 parts, Herba Hyperici Patuli 16 parts; Herba Peperomiae pellucidae 19 parts, Radix Corni Paucinervis 11 parts, Radix Camptandrae Yunnanensis 21 parts, Herba Morindae Parvifoliae 14 parts, Semen Granati 11 parts, Borneolum Syntheticum 4 parts, Semen Lini oil 19 parts.

3. prepare a method for pain relieving compound oil described in claim 1, it is characterized in that comprising the following steps:

A, the Caulis Vernoniae Andersonii of described parts by weight, Herba Hyperici Patuli, Herba Peperomiae pellucidae, Radix Corni Paucinervis, Radix Camptandrae Yunnanensis, Herba Morindae Parvifoliae, Semen Granati to be mixed after being ground into 40 order granules, adopt carbon dioxide supercritical fluid extraction, extracting pressure is 35 ~ 40MPa, extraction temperature is 38 ~ 42 DEG C, extraction time is 100 ~ 105min, CO2 flow, 20 ~ 30kg/h;

B, by the Borneolum Syntheticum of described parts by weight, make 400 object powder;

C, by the Semen Lini oil of described parts by weight, be heated to 60 ~ 70 DEG C, add the powder in step b successively, the extract mix homogeneously in step a.