CN104474217A - Traditional Chinese medicine preparation for improving neuralgic amyotrophy and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for improving neuralgic amyotrophy. The traditional Chinese medicine preparation is prepared from 20-40 parts by weight of ligusticum wallichii, 3-7 parts by weight of scallion, 15-25 parts by weight of typhonium giganteum, 15-25 parts by weight of deerhorn glue, 10-20 parts by weight of herba asari, 6-18 parts by weight of rhizoma drynariae, 20-30 parts by weight of dragon bone, 25-40 parts by weight of acanthopanax root, 8-13 parts by weight of raw licorice root, 13-28 parts by weight of bark of ash and 15-25 parts by weight of Chinese angelica. The traditional Chinese medicine preparation has the characteristics of preparation simpleness, taking convenience, carrying convenience and long-term use feasibility. The traditional Chinese medicine preparation has effects of dispelling wind and dredging collaterals, relaxing muscles and tendons and promoting blood circulation, supporting body resistance, reinforcing qi and nourishing blood, and promoting blood circulation to remove blood stasis and relieving pain.

Description

A traditional Chinese medicine preparation for improving neuromuscular atrophy and its preparation method

technical field

The invention relates to the field of traditional Chinese medicine, in particular to an oral liquid for improving neuromuscular atrophy and a preparation method thereof.

Background technique

Muscle atrophy refers to the loss of muscle volume caused by rhabdomyotrophy, the thinning or even disappearance of muscle fibers. The etiology mainly includes: neurogenic muscular atrophy, myogenic muscular atrophy, disuse muscular atrophy and other causes of muscular atrophy. In addition to the pathological changes of muscle tissue itself, muscle nutritional status is also closely related to the nervous system. Diseases of the spinal cord often lead to muscular dystrophy and muscle wasting. Patients with muscular atrophy are bedridden for a long time due to muscle atrophy and muscle weakness, and are prone to pneumonia and bedsores. In addition, most patients have symptoms of bulbar palsy, which poses a great threat to the lives of patients. For patients with muscular atrophy, besides asking a doctor to improve, self-regulation is very important.

Neurogenic muscular atrophy is that when a nerve impulse arrives, the nerve endings release the chemical transmitter acetylcholine, which temporarily binds to receptors on the endplate, increasing the permeability of the sarcolemma to sodium, allowing extracellular sodium ions to enter Cells, thereby depolarizing the membrane potential in the endplate region; when a certain threshold is reached, an action potential is generated on the surrounding sarcolemma. The action potential is transmitted to the sarcoplasmic reticulum, prompting it to release calcium ions to the sarcoplasm; the latter can promote the decomposition of adenosine triphosphate, release energy and make certain protein molecules in the muscle cells tightly fit, resulting in the contraction of the length of the muscle cells. Common causes of neurogenic muscular atrophy are disuse, nutritional disorders, ischemia, and poisoning. Anterior horn lesions, nerve roots, nerve plexuses, and muscle atrophy lesions of peripheral nerves can all cause conduction disorders of nerve excitation impulses, thereby disusing some muscle fibers and resulting in disuse muscle atrophy. On the other hand, when any part of the current motor neuron is damaged, the release of acetylcholine from the peripheral part decreases, and the trophic effect of the sympathetic nerve is weakened, resulting in muscle atrophy. Myogenic muscular atrophy is caused by the disease of the muscle itself, and may also include some other factors, such as shoulder girdle or facioscapulohumeral muscular dystrophy patients, confirmed by morphological examination as spinal muscular atrophy.

The Chinese patent document of application publication number CN 103432426 A (application number 201310416190.0) discloses a traditional Chinese medicine tablet for treating neuromuscular atrophy. 45 parts, Gastrodia 20-45 parts, Cinnamon 20-45 parts, Clematis 20-45 parts, Astragalus 30-50 parts, Lily 30-50 parts, Polygala 30-50 parts, Earthworm 1-5 parts, whole worm 1-5 servings.

In a word, traditional Chinese medicine has achieved good curative effect in improving this disease, but there are still some problems: clinically, it is not ideal for promoting blood circulation, removing blood stasis, dredging collaterals, expelling wind and cold, opening orifices and relieving pain, and it is not ideal for improving neuromuscular atrophy. The coming pain could be improved.

Contents of the invention

Aiming at the deficiencies of the prior art, the object of the present invention is to provide a traditional Chinese medicine preparation for improving neuromuscular atrophy, which is simple to prepare, convenient to take, easy to carry, and easy to take for a long time, and a preparation method thereof. The traditional Chinese medicine preparation has the effects of dispelling wind and dredging collaterals, relaxing tendons and activating blood circulation, strengthening the body, nourishing qi and nourishing blood, promoting blood circulation, removing blood stasis and relieving pain.

Technical scheme of the present invention is:

A traditional Chinese medicine preparation for improving neuromuscular atrophy, prepared from raw materials in the following weight proportions: 20-40 parts of Rhizoma Chuanxiong, 3-7 parts of spring onion, 15-25 parts of unicorn lotus, and 15-25 parts of deer horn glue , Asarum 10-20 parts, Drynaria 6-18 parts, keel 20-30 parts, Acanthopanax 25-40 parts, raw licorice 8-13 parts, Gentiana 13-28 parts and Angelica 15-25 parts.

The aforementioned Chinese medicine preparation, preferably, is prepared from the raw materials in the following weight proportions: 25-35 parts of Rhizoma Chuanxiong, 4-6 parts of green onion, 18-23 parts of unicorn lotus, 18-23 parts of antler gum 13-18 parts of Asarum, 10-14 parts of Drynaria, 23-28 parts of keel, 30-35 parts of Acanthopanax, 9-11 parts of raw licorice, 18-20 parts of Gentiana and 18-23 parts of Angelica.

The above-mentioned traditional Chinese medicine preparation, a more preferred solution is to be prepared from the raw materials in the following weight ratios: 30 parts of Rhizoma Chuanxiong, 5 parts of green onion, 20 parts of unicorn lotus, 20 parts of antler gum, 15 parts of Herba Asarum , 12 parts of drynaria, 25 parts of keel, 32 parts of Acanthopanax, 10 parts of raw licorice, 19 parts of Gentiana and 20 parts of angelica.

According to the preparation method of the traditional Chinese medicine preparation for improving neurogenic muscular atrophy described above, the steps are as follows:

(1) First wash Chuanxiong, unicorn lotus and angelica, beat into pieces the size of peppercorns, drain the water, put them in hot oil, and fry until fragrant, use a colander to chop the chuanxiong, unicorn lotus Take out the prickly ash and pepper, continue heating on low heat for 1-5 minutes, add deer horn glue, cool the oil to 30-40°C, put it into sealed bottles to obtain external medicinal oil;

(2) Break the keel into coin-sized pieces, put it on an iron plate and bake it on high heat for 20-30 minutes, let it cool and grind it into fine powder for later use;

(3) Remove the leaves of the green onion, cut the white of the green onion into small pieces the size of rice grains with a knife, put it in the gauze, and use a rolling pin to mash the green onion into puree for ultraviolet sterilization for 5-10 minutes, and set aside;

(4) Put Asarum, Rhizoma Drynariae, Acanthopanax, Raw Glycyrrhizae and Gentiana chinensis in a crock with white wine at 30-40°C (preferably 35°C) and seal it for 1-3 days (preferably 2 days). In a dry hot pot, stir-fry on low heat for 10-20 minutes, take it out and let it cool, and grind it into fine powder for later use;

(5) Put the results of steps (2)-(4) together in a casserole, add water 1-3 times the total weight of the mixed raw materials, heat it to boiling with high heat, and continue for 3-5 minutes (preferably 4 minutes), Change to slow fire and decoct. During the decoction, the traditional Chinese medicine is constantly stirred. When it becomes a thick paste, stop the fire, let it cool and bottle it to obtain the oral thick paste.

The preparation method described above, the preferred solution is: step (1) take out the Rhizoma Chuanxiong, unicorn lotus and Zanthoxylum bungeanum with a colander, continue heating on low heat for 2-4 minutes (preferably take out the chuanxiong, unicorn lotus and Zanthoxylum bungeanum with a colander , and continue to heat on low heat for 3 minutes).

The preferred solution of the aforementioned preparation method is: Step (1) After the oil is cooled to 33-38°C, it is divided into sealed bottles (preferably, after the oil is cooled to 35°C, it is divided into sealed bottles).

The preferred solution of the above-mentioned preparation method is: step (2) put it on an iron plate and bake it on high heat for 23-28 minutes (preferably put it on an iron plate and bake it on high fire for 25 minutes).

For the above-mentioned preparation method, the preferred solution is: step (3) 7-9 minutes of ultraviolet sterilization of pureed green onion (preferably 8 minutes of ultraviolet sterilization of pureed green onion).

The preferred method of the above-mentioned preparation method is: step (4) stir-fry on low heat for 13-18 minutes (preferably stir-fry on low heat for 15 minutes).

The preferred solution of the above-mentioned preparation method is: step (5) add water 1.5-2.5 times the total weight of the mixed raw drug (preferably add water twice the total weight of the mixed raw drug).

Method of use: In order to achieve the best improvement effect of the present invention, the prepared thick ointment is boiled and taken with boiling water half an hour after three meals, 5 grams each time, and 10 days is a course of treatment. The obtained medicated oil is applied on the atrophied Parts, after smearing, gently massage three circles left, right, up and down.

The pharmacology of main Chinese medicine raw material used in the present invention is as follows:

Ligusticum Chuanxiong: Ligusticum chuanxiong is a traditional Chinese medicine plant, which is often used to promote blood circulation and qi, dispel wind and relieve pain. Ligusticum chuanxiong is pungent, fragrant and dry. It has a wide range of functions of promoting blood circulation and removing blood stasis, suitable for stagnation of various diseases; dispelling wind and relieving pain, has very good effects, and can cure head wind, headache, rheumatic arthralgia and other diseases. The ancients said that Chuanxiong is the qi medicine in the blood, and it is almost said that it has the functions of dispersing pungent, relieving depression, opening up the mind, and relieving pain.

Onion: alias Heshicao, scallion, cabbage, fire onion, four seasons onion. Nature, flavor and efficacy Pungent, warm, enters the lung and stomach meridian. The outer substance is hollow, rising more and falling less, and its function is to diverge and unblock yang. It can not only disperse wind and cold, sweat and relieve muscles, and is used to improve mild symptoms of typhoid fever, cold and heat headache; Yin and cold, it is used to improve Qi and blood coagulation, dizziness and headache, stagnation of Qi caused by cold condensation, abdominal distension and abdominal pain, and bladder gasification failure and dysuria, etc.; in addition, it also has detoxification and hemostasis functions. It can promote yang and activate blood circulation, deworming and detoxification, sweating and sweating. It is mainly used to treat mild symptoms of wind-cold and cold, carbuncle and sore, dysentery with weak pulse, abdominal pain due to cold coagulation, dysuria and other diseases. 1. Antipyretic and expectorant: active ingredients such as scallion oil can stimulate the sweat glands of the body to achieve sweating and heat dissipation; scallion oil stimulates the upper respiratory tract, making sticky phlegm easy to spit out. 2. Promote digestion and absorption: onion also stimulates the secretion of digestive juice in the body, can invigorate the spleen and appetizer, and increase appetite. 3. Antibacterial, antiviral 4. Anti-cancer and anti-cancer.

Unicorn lotus: alias Yu Baifu, Milk Baifu, Red Male Star, Ma Yuzi, Wild Pinellia, and Chicken Heart Baifu. Sexual flavor effect Pungent, sweet, warm. poisonous. Return stomach, Liver Channel. Function drying dampness and eliminating phlegm, wind cowardice relieving convulsion, detoxification powder knot. It is suitable for wind-phlegm stagnation in collaterals, crooked mouth and eyes, stroke with phlegm excess, hemiplegia, aphasia, tetanus and cold-damp headache; external use for scrofula with phlegm nucleus and venomous snake bites.

Deer horn glue: This product is flat and square. Yellowish-brown or reddish-brown, translucent, and some have a yellowish-white foam layer on the upper part. Crisp, brittle, bright section. Slight gas, slightly sweet taste. Deer antler glue, warming and tonifying liver and kidney, nourishing essence and nourishing blood. For dizziness due to blood deficiency, soreness and coldness of the waist and knees, fatigue and emaciation.

Asarum: pungent, warm. Guixin, lung, kidney channel. Also known as: Hua Asarum, Xiaoxin, Shaoxin, Pontcao Asarum, etc., it belongs to the order Aristolochia, a perennial herb of the Aristolochiaceae, dispels wind, dispels cold, promotes water, and resuscitates. Control wind-cold headache, nasal sinusitis, toothache, phlegm retention and cough, rheumatic arthralgia. Herba Asarum can dispel wind-cold externally and dispel yin-cold internally, and has better analgesic and antitussive effects at the same time.

Rhizoma Drynariae: Rhizoma Drynariae, aliases: Yajiang, Yanlian Jiang, Climbing Rock Ginger, Meat Drynaria, Stone Drynaria, Flying Squirrel, Niufeilong, Feilaifeng, Moth Grass. Tonify the kidney and strengthen the bones, relieve pain after injury. It is used for low back pain due to kidney deficiency, tinnitus and deafness, loose teeth, tumbling and frustrating, tendon fractures; external treatment of alopecia areata and vitiligo.

Keel: Basic: It is the skeleton fossil of ancient mammals such as elephants, rhinos, three-toed horses, cattle, and deer. Ingredients: The keel mainly contains calcium carbonate and calcium phosphate, and also contains iron, potassium, sodium, chlorine, sulfate, etc. Properties of medicine: astringent, sweet, flat. GUIXIN, liver, kidney, large intestine channel. Functions and indications: Calming the heart and calming the nerves, calming the liver and suppressing yang, astringing and astringent. Indications for palpitations, swelling, insomnia, forgetfulness, epilepsy, mania, dizziness, spontaneous sweating, nocturnal emission and enuresis, metrorrhagia, protracted diarrhea, persistent ulcers and eczema. Taboo: Take it with caution for those with stagnant excess heat.

Acanthopanax: base: the roots, rhizomes or stems and leaves of Acanthopanax genus Araliaceae. Ingredients: Root contains eleutheroside A, B, B1, C, D, E, eleutheroside A is carotin, eleutheroside B is syringin; root also contains sinapin glucoside, coniferin aldehyde glucoside wait. Properties of medicine: "Shaanxi Traditional Chinese Medicine Annals": "pungent, warm, enters the liver and kidney meridians." Functions and indications: replenishing qi, tonifying the kidney, calming the nerves, and promoting blood circulation. Indications of spleen deficiency and fatigue, qi deficiency and edema, insomnia and dreaminess, forgetfulness, weakness of the waist and knees, delayed walking in children, chest pain, chronic cough, and rheumatic arthralgia.

Raw licorice: aliases: Meicao, Migan, Micao, Guolao, Fencao, Sweetgrass, Sweetroot, and Stickgrass are perennial herbaceous plants of the leguminous family. Traditional Chinese medicine believes that it has the functions of nourishing the middle and replenishing qi, clearing heat and detoxification, eliminating phlegm and relieving cough, relieving spasm and pain, and reconciling the properties of medicine. Nature and flavor: sweet, flat. Meridians: Guixin, Lung, Spleen, Stomach. Functions and indications: invigorating the spleen and replenishing qi, clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasm and relieving pain, harmonizing various medicines. For weakness of the spleen and stomach, lassitude and weakness, palpitation and shortness of breath, cough with copious phlegm, epigastric abdomen, extremity convulsion acute pain, carbuncle sore tumefacting virus, alleviates drug toxicity, strong.

Gentiana chinensis: alias ground smoked, mountain vegetables, mushroom grass, firewood. Nature and flavor are bitter, slightly cold. Return liver, gallbladder channel. It has the effects of reconciling exterior and interior, soothing the liver, and promoting yang. For cold and fever, alternating cold and heat, malaria, liver depression and Qi stagnation, sternocostal pain, anal prolapse, uterine prolapse, and irregular menstruation.

Angelica, also known as Gangui, Qinna, Xianggui, Minanggui, Jinanggui, Dangguishen, Hanguiwei, Dangguiqu, Tuanggui, is a perennial herb whose root can be used as medicine, and is one of the most commonly used traditional Chinese medicines. Enrich blood and blood, regulate menstruation and relieve pain, moisten dryness and smooth intestines. For blood deficiency, sallow complexion, dizziness and palpitation; blood deficiency, or irregular menstruation, amenorrhea, and dysmenorrhea with stasis; abdominal pain due to deficiency and cold, angina pectoris of coronary heart disease, rheumatism arthralgia, bruises and other pain syndromes; dry constipation; chronic cough and asthma.

The traditional Chinese medicine preparation of the present invention conforms to the principle of improving syndrome differentiation of traditional Chinese medicine. The selected medicinal materials are divided into thick ointment for oral administration and medicinal oil for external use. Both internal and external treatment can improve more comprehensively, and the lesions can be administered more quickly, with long-lasting efficacy. A good improvement effect not only has a good improvement effect on neuromuscular atrophy, but also has a very good curative effect on trigeminal neuralgia. In addition, the excellent effects of the present invention are also manifested in:

1. Among the selected materials, Chuanxiong, spring onion, deer horn glue, raw licorice and Gentiana quinquefolius have the effects of removing blood stasis and promoting blood circulation. Other raw materials have the effects of improving muscle and bone pain, calming the nerves, and clearing the orifice. The combination of raw materials with different functions has played a role Shujinhuoxue, strengthening the body, nourishing qi and blood, promoting blood circulation, removing blood stasis, relieving pain, and improving the effect of neuromuscular atrophy;

2. This prescription is completely in line with the principles of traditional Chinese medicine and the physical and mental characteristics of patients with neuromuscular atrophy. Under the premise of the general principle, different prescriptions can be formulated according to different groups of people, with different functions.

3. The source of medicine is easy to obtain, and the cost of medicinal materials is low, which can reduce the burden on patients.

Detailed ways

The technical solutions of the present invention will be described in detail below in conjunction with the examples and experimental examples, but the scope of protection is not limited thereto.

Embodiment 1 The traditional Chinese medicine preparation for improving neurogenic muscular atrophy is prepared according to the following parts by weight (20 g for each part): 20 parts of Rhizoma Chuanxiong, 3 parts of spring onion, 15 parts of unicorn lotus, 15 parts of antler gum, 10 parts of Asarum, bone Drynaria 6 parts, keel 20 parts, Acanthopanax 25 parts, raw licorice 8 parts, Gentiana 13 parts and Angelica 15 parts.

The preparation method of the above-mentioned traditional Chinese medicine preparation for improving neurogenic muscular atrophy:

(1) First wash Chuanxiong, unicorn lotus and angelica, beat into pieces the size of peppercorns, drain the water, put them in hot oil, and fry until fragrant, use a colander to chop the chuanxiong, unicorn lotus Take out the prickly ash and pepper, continue to heat on low heat for 1 minute, add deer horn glue, cool the oil to 30°C, and put it into sealed bottles to obtain external medicinal oil;

(2) Break the keel into coin-sized pieces, put it on an iron plate and bake it on high heat for 20 minutes, let it cool and grind it into fine powder for later use;

(3) Remove the leaves of the green onion, cut the white of the green onion into small pieces with a knife, put it in the gauze, and use a rolling pin to mash the green onion into puree for ultraviolet sterilization for 5 minutes, and set aside;

(4) Put Asarum, Rhizoma Drynariae, Acanthopanax, Raw Glycyrrhizae and Gentiana chinensis in a crock pot with white wine at 30°C and let it stand for 1 day, then put it in a dry hot pot, and stir-fry for 10 minutes , take it out and let it cool, grind it into fine powder for later use;

(5) Put the results of steps (2)-(4) together in a casserole, add water that is 1 times the total weight of the mixed raw materials, heat to boiling with high heat, and after 3 minutes, change to simmer and cook, the process of boiling Stir the traditional Chinese medicine continuously, and when it becomes a thick ointment, stop the fire, let it cool and bottle it to get the thick ointment for oral administration.

Typical case 1 : Wang XX, female, 45 years old, is a farmer from Jiyang, Jinan, Shandong. Unexplained symptoms of sensitive facial pain, drooping corners of the mouth, soft neck, and sore lower limbs. At first I thought it was a cold, but I didn’t pay much attention to it. I just gave him some painkillers. After taking the medicine, the symptoms improved, and then stopped. medicine. About a month later, numbness, fatigue, and other symptoms of limbs reappeared, and it was difficult to walk. The family members were very anxious, so they took him to a large hospital for a comprehensive examination, and he was diagnosed with neurogenic muscular atrophy. Delay own studies, just require to take the oral liquid of gained of the present invention.

Oral administration of the preparation obtained in Example 1 of the present invention combined with the use of the medicated oil obtained in Example 1 of the present invention, after 5 days, the above symptoms were significantly improved, and the mental state was very good. After continuing to take a course of treatment, there was basically no recurrence, and continued to take After 1 course of treatment, the above symptoms basically disappeared, and there was no recurrence after drug withdrawal.

Embodiment 2 The traditional Chinese medicine preparation for improving neurogenic muscular atrophy is prepared according to the following parts by weight (20 g for each part): 40 parts of Rhizoma Chuanxiong, 7 parts of spring onion, 25 parts of unicorn lotus, 25 parts of antler gum, 20 parts of Asarum, bone Drynaria 18 parts, keel 30 parts, Acanthopanax 40 parts, raw licorice 13 parts, Gentiana 28 parts and Angelica 25 parts.

The preparation method of the traditional Chinese medicine preparation for improving neurogenic muscular atrophy is:

(1) First wash Chuanxiong, unicorn lotus and angelica, beat into pieces the size of peppercorns, drain the water, put them in hot oil, and fry until fragrant, use a colander to chop the chuanxiong, unicorn lotus Take out the prickly ash and pepper, continue to heat on low heat for 5 minutes, add deer horn glue, cool the oil to 40°C, and put it into sealed bottles to obtain external medicinal oil;

(2) Break the keel into coin-sized pieces, put it on an iron plate and bake it on high heat for 30 minutes, let it cool and grind it into fine powder for later use;

(3) Remove the leaves of the green onion, cut the white of the green onion into small pieces with a knife, put it in the gauze, use a rolling pin to mash the green onion into puree, and sterilize it with ultraviolet light for 10 minutes, and set aside;

(4) Put Asarum, Rhizoma Drynariae, Acanthopanax, Raw Glycyrrhizae and Gentiana chinensis in a crock pot with white wine at 40°C and let it stand for 3 days, then put it in a dry hot pot, and stir-fry for 20 minutes , take it out and let it cool, grind it into fine powder for later use;

(5) Put the results of steps (2)-(4) together in a casserole, add water that is 3 times the total weight of the mixed raw materials, heat to boiling with strong fire, and after 5 minutes, change to simmer and cook, the process of boiling Stir the traditional Chinese medicine continuously, and when it becomes a thick ointment, stop the fire, let it cool and bottle it to get the thick ointment for oral administration.

Embodiment 3 The traditional Chinese medicine preparation for improving neurogenic muscular atrophy is prepared according to the following parts by weight (20 g for each part): 25 parts of Rhizoma Chuanxiong, 4 parts of spring onion, 18 parts of unicorn lotus, 18 parts of antler gum, 13 parts of asarum, bone Drynaria 10 parts, keel 23 parts, Acanthopanax 30 parts, raw licorice 9 parts, Gentiana 18 parts and Angelica 18 parts.

The preparation method of the traditional Chinese medicine preparation for improving neurogenic muscular atrophy is:

(1) First wash Chuanxiong, unicorn lotus and angelica, beat into pieces the size of peppercorns, drain the water, put them in hot oil, and fry until fragrant, use a colander to chop the chuanxiong, unicorn lotus Take out the prickly ash and pepper, continue to heat on low heat for 2 minutes, add deer horn glue, cool the oil to 33°C, and put it into sealed bottles to obtain external medicinal oil;

(2) Break the keel into coin-sized pieces, put it on an iron plate and bake it on high heat for 23 minutes, let it cool and grind it into fine powder for later use;

(3) Remove the leaves of the green onion, cut the white of the green onion into small pieces with a knife, put it in the gauze, and use a rolling pin to mash the green onion into puree for ultraviolet sterilization for 7 minutes, and set aside;

(4) Put Asarum, Rhizoma Drynariae, Acanthopanax, Raw Glycyrrhizae and Gentiana chinensis in a crock pot with 33°C white wine and seal it for 1.5 days, then put it in a dry hot pot, and stir-fry for 13 minutes , take it out and let it cool, grind it into fine powder for later use;

(5) Put the results of steps (2)-(4) together in a casserole, add water 1.5 times the total weight of the mixed raw materials, heat it to boiling with high heat, and after 3.5 minutes, change to a slow fire and decoct. The process of decocting Stir the traditional Chinese medicine continuously, and when it becomes a thick ointment, stop the fire, let it cool and bottle it to get the thick ointment for oral administration.

Typical Case 2: Lin XX, male, 42 years old, from Jinan, Shandong Province, a working cadre, experienced unexplained weakness in his right hand 2 years ago. At first, he put on a few plasters because he was taking care of the child and was tired. But the effect was not good. After 5 days, the grip strength decreased, and then the symptoms of difficulty in straightening fingers appeared, and he could not eat independently. He went to the hospital for examination and was finally diagnosed as right hand neurogenic muscular atrophy. At present, there is no effective treatment method. Liquid later come to buy for treatment.

Taking the traditional Chinese medicine preparation obtained in Example 3 of the present invention and using the medicated oil obtained in Example 3 together, after one course of treatment, the patient can hold things with his right hand and do some simple movements. After taking two courses of treatment, the patient's previous symptoms are basically improved, and he can Have a meal, after continuing to take 2 courses for the treatment of, uncomfortable symptom disappears, and the patient feels fully recovered, and mental state is excellent.

Embodiment 4 The traditional Chinese medicine preparation for improving neurogenic muscular atrophy is prepared according to the following parts by weight (20 g for each part): 35 parts of Rhizoma Chuanxiong, 6 parts of green onion, 23 parts of unicorn lotus, 23 parts of antler gum, 18 parts of Asarum, bone Drynaria 14, Keel 28, Acanthopanax 35, Raw Licorice 11, Gentiana 20 and Angelica 23.

The preparation method of the traditional Chinese medicine preparation for improving neurogenic muscular atrophy is:

(1) First wash Chuanxiong, unicorn lotus and angelica, beat into pieces the size of peppercorns, drain the water, put them in hot oil, and fry until fragrant, use a colander to chop the chuanxiong, unicorn lotus Take out the prickly ash and pepper, continue to heat on low heat for 4 minutes, add deer horn glue, cool the oil to 38°C, and put it into sealed bottles to obtain external medicinal oil;

(2) Break the keel into coin-sized pieces, put it on an iron plate and bake it on high heat for 28 minutes, let it cool and grind it into fine powder for later use;

(3) Remove the leaves of the green onion, cut the white of the green onion into small pieces with a knife, put it in the gauze, use a rolling pin to mash the green onion into puree and sterilize it with ultraviolet light for 9 minutes, and set aside;

(4) Put Asarum, Rhizoma Drynariae, Acanthopanax, Raw Glycyrrhizae and Gentiana chinensis in an earthen jar with 38°C white wine and seal it for 2.5 days, put it in a dry hot pot, and stir-fry for 18 minutes , take it out and let it cool, grind it into fine powder for later use;

(5) Put the results of steps (2)-(4) together in a casserole, add water 2.5 times the total weight of the mixed raw materials, heat to boiling with high heat, and after 4.5 minutes, change to simmer and cook, the process of boiling Stir the traditional Chinese medicine continuously, and when it becomes a thick ointment, stop the fire, let it cool and bottle it to get the thick ointment for oral administration.

Example 5 The traditional Chinese medicine preparation for improving neurogenic muscular atrophy is prepared according to the following parts by weight (20 g for each part): 30 parts of Rhizoma Chuanxiong, 5 parts of green onion, 20 parts of unicorn lotus, 20 parts of antler gum, 15 parts of Asarum, bone Drynaria 12 parts, keel 25 parts, Acanthopanax 32 parts, raw licorice 10 parts, Gentiana 19 parts and Angelica 20 parts.

The preparation method of the traditional Chinese medicine preparation for improving neurogenic muscular atrophy is:

(1) First wash Chuanxiong, unicorn lotus and angelica, beat into pieces the size of peppercorns, drain the water, put them in hot oil, and fry until fragrant, use a colander to chop the chuanxiong, unicorn lotus Take out the prickly ash and pepper, continue to heat on low heat for 3 minutes, add deer horn glue, cool the oil to 35°C, and put it into sealed bottles to obtain external medicinal oil;

(2) Break the keel into coin-sized pieces, put it on an iron plate and bake it on high heat for 25 minutes, let it cool and grind it into fine powder for later use;

(3) Remove the leaves of the green onion, cut the white of the green onion into small pieces with a knife, put it in the gauze, and use a rolling pin to mash the green onion into puree for ultraviolet sterilization for 8 minutes, and set aside;

(4) Put Asarum, Rhizoma Drynariae, Acanthopanax, Raw Glycyrrhizae and Gentiana chinensis in a crock pot with white wine at 35°C and let it stand for 2 days, put it in a dry hot pot, and stir-fry for 15 minutes , take it out and let it cool, grind it into fine powder for later use;

(5) Put the results of steps (2)-(4) together in a casserole, add water twice the total weight of the mixed raw materials, heat to boiling with strong fire, and after 4 minutes, change to slow fire and cook, the process of boiling Stir the traditional Chinese medicine continuously, and when it becomes a thick ointment, stop the fire, let it cool and bottle it to get the thick ointment for oral administration.

Clinical application of the Chinese medicinal preparation for improving neuromuscular atrophy obtained in Example 1 of Test Example 5: 400 patients with neuromuscular atrophy were selected in 10 hospitals. One week before the test, the crowd was continuously observed, and symptoms and changes were recorded. Randomly divided into two groups, the experimental group and the control group, the experimental group took the product obtained in Example 5, and the control group took other medicines (Jingfukang, Wantong Jingu Tablets, Jingyaokang Capsules and other conventional medicines). Criterion of curative effect situation: cure: after taking the tablet gained in embodiment 5 and coordinating the medicated oil gained in embodiment 5, the symptoms of discomfort are obviously improved, and the pain disappears substantially; After taking the medicated oil, the discomfort symptoms were improved and the pain was relieved; invalid: after taking this product, the discomfort symptoms did not change. The results are shown in Table 1.

Table 1:

The effective rate of the Chinese medicine preparation obtained by the present invention is as high as 99%, and the cure rate is as high as 97%, and the effect is obviously better than that of the experimental group. After taking the product of the present invention for 5 days, the symptoms of discomfort are improved, and the pain is alleviated; after taking the product for 10 days, the symptoms of discomfort are improved. or disappear, and the pain basically disappeared; after taking it for 20 days, the discomfort symptoms improved or disappeared, and some patients felt that they were cured.

It should be noted that the specific implementation is only a representative example of the present invention, and obviously the technical solution of the present invention is not limited to the above-mentioned embodiments, and many variations are possible. Those of ordinary skill in the art, based on the disclosure of the present invention or obtained without objection from the written description of the document, should be considered as the protection scope of this patent.

Claims (8)

1. A traditional Chinese medicine preparation for improving neurogenic muscular atrophy, characterized in that: it is prepared from the crude drug of the following weight ratio: 20-40 parts of Rhizoma Chuanxiong, 3-7 parts of green onion, 15-25 parts of Rhizoma unicorn, 15-25 parts of antler gum, 10-20 parts of Asarum, 6-18 parts of drynaria, 20-30 parts of keel, 25-40 parts of Acanthopanax, 8-13 parts of raw licorice, 13-28 parts of Gentiana and angelica 15-25 servings. 2. The traditional Chinese medicine preparation according to claim 1, characterized in that: it is prepared from raw materials in the following weight ratios: 25-35 parts of Rhizoma Chuanxiong, 4-6 parts of green onion, 18-23 parts of unicorn lotus, 18-23 parts of antler 18-23 parts of glue, 13-18 parts of Asarum, 10-14 parts of drynaria, 23-28 parts of keel, 30-35 parts of Acanthopanax, 9-11 parts of raw licorice, 18-20 parts of Gentiana and 18 parts of angelica -23 copies. 3. The traditional Chinese medicine preparation according to claim 1, characterized in that: it is prepared from the raw materials in the following weight ratios: 30 parts of Rhizoma Chuanxiong, 5 parts of green onion, 20 parts of unicorn lotus, 20 parts of antler gum, Asarum 15 parts, Drynaria 12 parts, keel 25 parts, Acanthopanax 32 parts, raw licorice 10 parts, Gentiana 19 parts and Angelica 20 parts. 4. According to the preparation method of the Chinese medicine preparation improving neuromuscular atrophy according to claim 4, it is characterized in that: the steps are as follows: (1) First wash Chuanxiong, unicorn lotus and angelica, beat into pieces the size of peppercorns, drain the water, put them in hot oil, and fry until fragrant, use a colander to chop the chuanxiong, unicorn lotus Take out the prickly ash and pepper, continue heating on low heat for 1-5 minutes, add deer horn glue, cool the oil to 30-40°C, put it into sealed bottles to obtain external medicinal oil; (2) Break the keel into coin-sized pieces, put it on an iron plate and bake it on high heat for 20-30 minutes, let it cool and grind it into fine powder for later use; (3) Remove the leaves of the green onion, cut the white of the green onion into small pieces the size of rice grains with a knife, put it in the gauze, and use a rolling pin to mash the green onion into puree for ultraviolet sterilization for 5-10 minutes, and set aside; (4) Put Asarum, Rhizoma Drynariae, Acanthopanax, Raw Glycyrrhizae and Gentiana chinensis in a crock with white wine at 30-40°C (preferably 35°C) and seal it for 1-3 days (preferably 2 days). In a dry hot pot, stir-fry on low heat for 10-20 minutes, take it out and let it cool, grind it into fine powder for later use; (5) Put the results of steps (2)-(4) together in a casserole, add water 1-3 times the total weight of the mixed raw materials, heat it to boiling with high heat, and continue for 3-5 minutes (preferably 4 minutes), Change to slow fire and decoct. During the decoction, the traditional Chinese medicine is constantly stirred. When it becomes a thick paste, stop the fire, let it cool and bottle it to obtain the oral thick paste. 5. The preparation method according to claim 4, characterized in that: step (1) take out the Rhizoma Chuanxiong, the unicorn lotus and Zanthoxylum bungeanum with a colander, continue heating on low heat for 2-4 minutes (preferably use a colander to remove the chuanxiong, unicorn lotus Take out the lotus and peppercorns, and continue to heat on low heat for 3 minutes). 6. The preparation method according to claim 4, characterized in that: Step (1) After the oil is cooled to 33-38°C, it is divided into sealed bottles (preferably after the oil is cooled to 35°C, it is divided into sealed bottles ). 7 . The preparation method according to claim 4 , characterized in that: step (2) place on an iron plate and bake on high heat for 23-28 minutes (preferably place on iron plate and bake on high heat for 25 minutes). 8 . The preparation method according to claim 4 , characterized in that: step (3) 7-9 minutes of ultraviolet sterilizing of pureed green onion (preferably 8 minutes of ultraviolet sterilizing of pureed green onion).